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Patent code US9212182

Compile Data Set for Download or QSAR

Found 776 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217776
PNG
(US9212182, 1029)
Show SMILES COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cc(Cl)ccc1C
Show InChI InChI=1S/C26H20ClN3O5S/c1-16-3-6-19(27)15-21(16)17-4-8-23(24(14-17)34-2)30-22-9-7-20(13-18(22)5-10-26(30)31)36(32,33)29-25-11-12-35-28-25/h3-15H,1-2H3,(H,28,29)
PDB

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US Patent
n/an/a 3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217522
PNG
(US9212182, 367 | US9212182, 368)
Show SMILES COc1cc(c(Cl)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccncn1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C27H20Cl2N4O4S/c1-16-11-17(3-6-21(16)28)20-13-25(37-2)24(14-22(20)29)33-23-7-5-19(12-18(23)4-8-27(33)34)38(35,36)32-26-9-10-30-15-31-26/h3-15H,1-2H3,(H,30,31,32)
PDB

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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217840
PNG
(US9212182, 1074)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1nncs1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C25H18ClFN4O4S2/c1-14-9-15(3-6-19(14)26)18-11-23(35-2)22(12-20(18)27)31-21-7-5-17(10-16(21)4-8-24(31)32)37(33,34)30-25-29-28-13-36-25/h3-13H,1-2H3,(H,29,30)
PDB

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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217534
PNG
(US9212182, 501 | US9212182, 502)
Show SMILES COc1cc(Cl)cc(c1)-c1cc(OC)c(cc1F)-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1
Show InChI InChI=1S/C26H19ClFN3O6S/c1-35-18-10-16(9-17(27)12-18)20-13-24(36-2)23(14-21(20)28)31-22-5-4-19(11-15(22)3-6-26(31)32)38(33,34)30-25-7-8-37-29-25/h3-14H,1-2H3,(H,29,30)
PDB

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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217798
PNG
(US9212182, 1053)
Show SMILES COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cc(ccc1C)C(F)(F)F
Show InChI InChI=1S/C27H20F3N3O5S/c1-16-3-6-19(27(28,29)30)15-21(16)17-4-8-23(24(14-17)37-2)33-22-9-7-20(13-18(22)5-10-26(33)34)39(35,36)32-25-11-12-38-31-25/h3-15H,1-2H3,(H,31,32)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217841
PNG
(US9212182, 1075)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ncns1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C25H18ClFN4O4S2/c1-14-9-15(3-6-19(14)26)18-11-23(35-2)22(12-20(18)27)31-21-7-5-17(10-16(21)4-8-24(31)32)37(33,34)30-25-28-13-29-36-25/h3-13H,1-2H3,(H,28,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217424
PNG
(US9212182, 533 | US9212182, 534)
Show SMILES COc1cc(c(Cl)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H17ClF3N3O5S/c1-37-23-13-19(15-3-2-4-17(11-15)26(28,29)30)20(27)14-22(23)33-21-7-6-18(12-16(21)5-8-25(33)34)39(35,36)32-24-9-10-38-31-24/h2-14H,1H3,(H,31,32)
PDB

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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217665
PNG
(US9212182, 922)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1cnsn1)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C24H15ClF2N4O4S2/c1-35-22-10-18(14-6-15(25)9-16(26)7-14)19(27)11-21(22)31-20-4-3-17(8-13(20)2-5-24(31)32)37(33,34)30-23-12-28-36-29-23/h2-12H,1H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217828
PNG
(US9212182, 662)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccncn1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C27H20ClFN4O4S/c1-16-11-17(3-6-21(16)28)20-13-25(37-2)24(14-22(20)29)33-23-7-5-19(12-18(23)4-8-27(33)34)38(35,36)32-26-9-10-30-15-31-26/h3-15H,1-2H3,(H,30,31,32)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217715
PNG
(US9212182, 969)
Show SMILES COc1cc(Cl)cc(c1)-c1cc(OC)c(cc1C)-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ncccn1
Show InChI InChI=1S/C28H23ClN4O5S/c1-17-11-25(26(38-3)16-23(17)19-12-20(29)15-21(13-19)37-2)33-24-7-6-22(14-18(24)5-8-27(33)34)39(35,36)32-28-30-9-4-10-31-28/h4-16H,1-3H3,(H,30,31,32)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217885
PNG
(US9212182, 790)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C1CC1
Show InChI InChI=1S/C28H22FN3O5S/c1-36-26-15-22(19-4-2-3-18(13-19)17-5-6-17)23(29)16-25(26)32-24-9-8-21(14-20(24)7-10-28(32)33)38(34,35)31-27-11-12-37-30-27/h2-4,7-17H,5-6H2,1H3,(H,30,31)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217725
PNG
(US9212182, 652 | US9212182, 653 | US9212182, 654)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ncc1=O)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C25H18ClFN4O5S/c1-14-9-15(3-5-18(14)26)17-11-23(35-2)22(12-19(17)27)31-21-6-4-16(10-20(21)28-13-25(31)32)37(33,34)30-24-7-8-36-29-24/h3-13H,1-2H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217987
PNG
(US9212182, 703)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cccc(Cl)c1F
Show InChI InChI=1S/C25H16ClF2N3O5S/c1-35-22-12-17(16-3-2-4-18(26)25(16)28)19(27)13-21(22)31-20-7-6-15(11-14(20)5-8-24(31)32)37(33,34)30-23-9-10-36-29-23/h2-13H,1H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217451
PNG
(US9212182, 326)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ncco1)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C25H16ClF2N3O5S/c1-35-23-12-19(15-8-16(26)11-17(27)9-15)20(28)13-22(23)31-21-4-3-18(10-14(21)2-5-24(31)32)37(33,34)30-25-29-6-7-36-25/h2-13H,1H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM218033
PNG
(US9212182, 743)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cc(Cl)ccc1C
Show InChI InChI=1S/C26H19ClFN3O5S/c1-15-3-5-17(27)12-19(15)20-13-24(35-2)23(14-21(20)28)31-22-7-6-18(11-16(22)4-8-26(31)32)37(33,34)30-25-9-10-36-29-25/h3-14H,1-2H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217984
PNG
(US9212182, 700)
Show SMILES COc1cc(ccc1Cl)-c1cc(OC)c(cc1F)-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1
Show InChI InChI=1S/C26H19ClFN3O6S/c1-35-23-12-15(3-6-19(23)27)18-13-24(36-2)22(14-20(18)28)31-21-7-5-17(11-16(21)4-8-26(31)32)38(33,34)30-25-9-10-37-29-25/h3-14H,1-2H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217813
PNG
(US9212182, 1067)
Show SMILES COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ncco1)-c1cc(Cl)ccc1C
Show InChI InChI=1S/C26H20ClN3O5S/c1-16-3-6-19(27)15-21(16)17-4-8-23(24(14-17)34-2)30-22-9-7-20(13-18(22)5-10-25(30)31)36(32,33)29-26-28-11-12-35-26/h3-15H,1-2H3,(H,28,29)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217864
PNG
(US9212182, 1095)
Show SMILES COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1cccnn1)-c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C27H18F4N4O4S/c1-39-24-14-16(18-11-19(27(29,30)31)15-20(28)12-18)4-7-23(24)35-22-8-6-21(13-17(22)5-9-26(35)36)40(37,38)34-25-3-2-10-32-33-25/h2-15H,1H3,(H,33,34)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217883
PNG
(US9212182, 788)
Show SMILES COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C1CC1
Show InChI InChI=1S/C28H23N3O5S/c1-35-26-17-21(20-4-2-3-19(15-20)18-5-6-18)7-10-25(26)31-24-11-9-23(16-22(24)8-12-28(31)32)37(33,34)30-27-13-14-36-29-27/h2-4,7-18H,5-6H2,1H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217669
PNG
(US9212182, 926)
Show SMILES COc1cc(Cl)cc(c1)-c1cc(OC)c(cc1F)-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ncco1
Show InChI InChI=1S/C26H19ClFN3O6S/c1-35-18-10-16(9-17(27)12-18)20-13-24(36-2)23(14-21(20)28)31-22-5-4-19(11-15(22)3-6-25(31)32)38(33,34)30-26-29-7-8-37-26/h3-14H,1-2H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217837
PNG
(US9212182, 663)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ncon1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C25H18ClFN4O5S/c1-14-9-15(3-6-19(14)26)18-11-23(35-2)22(12-20(18)27)31-21-7-5-17(10-16(21)4-8-24(31)32)37(33,34)30-25-28-13-36-29-25/h3-13H,1-2H3,(H,29,30)
PDB

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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM218002
PNG
(US9212182, 716)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cc(C)ccc1Cl
Show InChI InChI=1S/C26H19ClFN3O5S/c1-15-3-6-20(27)18(11-15)19-13-24(35-2)23(14-21(19)28)31-22-7-5-17(12-16(22)4-8-26(31)32)37(33,34)30-25-9-10-36-29-25/h3-14H,1-2H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217677
PNG
(US9212182, 934)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccnc(C)n1)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C27H19ClF2N4O4S/c1-15-31-8-7-26(32-15)33-39(36,37)20-4-5-23-16(11-20)3-6-27(35)34(23)24-14-22(30)21(13-25(24)38-2)17-9-18(28)12-19(29)10-17/h3-14H,1-2H3,(H,31,32,33)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217481
PNG
(US9212182, 469 | US9212182, 470)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C26H19ClFN3O5S/c1-15-11-16(3-6-20(15)27)19-13-24(35-2)23(14-21(19)28)31-22-7-5-18(12-17(22)4-8-26(31)32)37(33,34)30-25-9-10-36-29-25/h3-14H,1-2H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217998
PNG
(US9212182, 712)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cccc(Cl)c1C
Show InChI InChI=1S/C26H19ClFN3O5S/c1-15-18(4-3-5-20(15)27)19-13-24(35-2)23(14-21(19)28)31-22-8-7-17(12-16(22)6-9-26(31)32)37(33,34)30-25-10-11-36-29-25/h3-14H,1-2H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217469
PNG
(US9212182, 461 | US9212182, 462)
Show SMILES COc1cc(c(Cl)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C25H16Cl2FN3O5S/c1-35-23-12-19(15-8-16(26)11-17(28)9-15)20(27)13-22(23)31-21-4-3-18(10-14(21)2-5-25(31)32)37(33,34)30-24-6-7-36-29-24/h2-13H,1H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217726
PNG
(US9212182, 1001 | US9212182, 1002 | US9212182, 978)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ncc1=O)S(=O)(=O)Nc1ncccn1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C26H19ClFN5O4S/c1-15-10-16(4-6-19(15)27)18-12-24(37-2)23(13-20(18)28)33-22-7-5-17(11-21(22)31-14-25(33)34)38(35,36)32-26-29-8-3-9-30-26/h3-14H,1-2H3,(H,29,30,32)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM218032
PNG
(US9212182, 742)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)cc1C
Show InChI InChI=1S/C26H19ClFN3O5S/c1-15-11-17(27)4-6-19(15)20-13-24(35-2)23(14-21(20)28)31-22-7-5-18(12-16(22)3-8-26(31)32)37(33,34)30-25-9-10-36-29-25/h3-14H,1-2H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217483
PNG
(US9212182, 477 | US9212182, 478)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C25H16ClF2N3O5S/c1-35-23-12-19(15-8-16(26)11-17(27)9-15)20(28)13-22(23)31-21-4-3-18(10-14(21)2-5-25(31)32)37(33,34)30-24-6-7-36-29-24/h2-13H,1H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217544
PNG
(US9212182, 508 | US9212182, 509)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)c(c1)C#N
Show InChI InChI=1S/C26H16ClFN4O5S/c1-36-24-12-19(15-2-5-20(27)17(10-15)14-29)21(28)13-23(24)32-22-6-4-18(11-16(22)3-7-26(32)33)38(34,35)31-25-8-9-37-30-25/h2-13H,1H3,(H,30,31)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217569
PNG
(US9212182, 528 | US9212182, 529)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1ccc(C)c(Cl)c1
Show InChI InChI=1S/C26H19ClFN3O5S/c1-15-3-4-16(12-20(15)27)19-13-24(35-2)23(14-21(19)28)31-22-7-6-18(11-17(22)5-8-26(31)32)37(33,34)30-25-9-10-36-29-25/h3-14H,1-2H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM218010
PNG
(US9212182, 723)
Show SMILES COc1cc(Cl)cc(c1)-c1cc(OC)cc(c1)-c1ccc(c(OC)c1)-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1
Show InChI InChI=1S/C33H26ClN3O7S/c1-41-26-14-22(12-23(15-26)24-13-25(34)19-27(16-24)42-2)20-4-7-30(31(18-20)43-3)37-29-8-6-28(17-21(29)5-9-33(37)38)45(39,40)36-32-10-11-44-35-32/h4-19H,1-3H3,(H,35,36)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217449
PNG
(US9212182, 542)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1cccnn1)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C26H17ClF2N4O4S/c1-37-24-13-20(16-9-17(27)12-18(28)10-16)21(29)14-23(24)33-22-6-5-19(11-15(22)4-7-26(33)34)38(35,36)32-25-3-2-8-30-31-25/h2-14H,1H3,(H,31,32)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217892
PNG
(US9212182, 633)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1ccc(cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C31H21ClFN3O5S/c1-40-29-17-25(21-4-2-19(3-5-21)20-6-9-23(32)10-7-20)26(33)18-28(29)36-27-12-11-24(16-22(27)8-13-31(36)37)42(38,39)35-30-14-15-41-34-30/h2-18H,1H3,(H,34,35)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM218034
PNG
(US9212182, 744)
Show SMILES COc1ccc(Cl)cc1-c1cc(OC)c(cc1F)-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1
Show InChI InChI=1S/C26H19ClFN3O6S/c1-35-23-7-4-16(27)12-19(23)18-13-24(36-2)22(14-20(18)28)31-21-6-5-17(11-15(21)3-8-26(31)32)38(33,34)30-25-9-10-37-29-25/h3-14H,1-2H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217504
PNG
(US9212182, 585 | US9212182, 586)
Show SMILES COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cc(C)cc(Cl)c1
Show InChI InChI=1S/C26H20ClN3O5S/c1-16-11-19(13-20(27)12-16)17-3-6-23(24(15-17)34-2)30-22-7-5-21(14-18(22)4-8-26(30)31)36(32,33)29-25-9-10-35-28-25/h3-15H,1-2H3,(H,28,29)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217542
PNG
(US9212182, 506 | US9212182, 507)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cc(C)cc(Cl)c1
Show InChI InChI=1S/C26H19ClFN3O5S/c1-15-9-17(11-18(27)10-15)20-13-24(35-2)23(14-21(20)28)31-22-5-4-19(12-16(22)3-6-26(31)32)37(33,34)30-25-7-8-36-29-25/h3-14H,1-2H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217471
PNG
(US9212182, 471 | US9212182, 472)
Show SMILES COc1cc(c(Cl)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C26H19Cl2N3O5S/c1-15-11-16(3-6-20(15)27)19-13-24(35-2)23(14-21(19)28)31-22-7-5-18(12-17(22)4-8-26(31)32)37(33,34)30-25-9-10-36-29-25/h3-14H,1-2H3,(H,29,30)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217977
PNG
(US9212182, 645)
Show SMILES COc1cc(C#CC2CCCC2)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1cccnn1
Show InChI InChI=1S/C27H23FN4O4S/c1-36-25-16-19(9-8-18-5-2-3-6-18)22(28)17-24(25)32-23-12-11-21(15-20(23)10-13-27(32)33)37(34,35)31-26-7-4-14-29-30-26/h4,7,10-18H,2-3,5-6H2,1H3,(H,30,31)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217671
PNG
(US9212182, 928)
Show SMILES COc1cc(Cl)cc(c1)-c1ccc(c(OC)c1)-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1cccnn1
Show InChI InChI=1S/C27H21ClN4O5S/c1-36-21-13-19(12-20(28)16-21)17-5-8-24(25(15-17)37-2)32-23-9-7-22(14-18(23)6-10-27(32)33)38(34,35)31-26-4-3-11-29-30-26/h3-16H,1-2H3,(H,30,31)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217676
PNG
(US9212182, 933)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1cc(C)ncn1)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C27H19ClF2N4O4S/c1-15-7-26(32-14-31-15)33-39(36,37)20-4-5-23-16(10-20)3-6-27(35)34(23)24-13-22(30)21(12-25(24)38-2)17-8-18(28)11-19(29)9-17/h3-14H,1-2H3,(H,31,32,33)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM218017
PNG
(US9212182, 728)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C26H17F4N3O6S/c1-37-23-13-19(15-3-2-4-17(11-15)39-26(28,29)30)20(27)14-22(23)33-21-7-6-18(12-16(21)5-8-25(33)34)40(35,36)32-24-9-10-38-31-24/h2-14H,1H3,(H,31,32)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217537
PNG
(US9212182, 503 | US9212182, 504)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C25H16ClF2N3O5S/c1-35-23-12-17(14-2-5-18(26)20(28)11-14)19(27)13-22(23)31-21-6-4-16(10-15(21)3-7-25(31)32)37(33,34)30-24-8-9-36-29-24/h2-13H,1H3,(H,29,30)
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n/an/a 8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217526
PNG
(US9212182, 480 | US9212182, 481)
Show SMILES COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1cccnn1)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C26H18ClFN4O4S/c1-36-24-14-16(18-11-19(27)15-20(28)12-18)4-7-23(24)32-22-8-6-21(13-17(22)5-9-26(32)33)37(34,35)31-25-3-2-10-29-30-25/h2-15H,1H3,(H,30,31)
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Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM218012
PNG
(US9212182, 597)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cc(C)cc(F)c1
Show InChI InChI=1S/C26H19F2N3O5S/c1-15-9-17(11-18(27)10-15)20-13-24(35-2)23(14-21(20)28)31-22-5-4-19(12-16(22)3-6-26(31)32)37(33,34)30-25-7-8-36-29-25/h3-14H,1-2H3,(H,29,30)
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n/an/a 8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217602
PNG
(US9212182, 613 | US9212182, 614 | US9212182, 615)
Show SMILES COc1cc(Cl)c(cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C25H16Cl2FN3O5S/c1-35-23-13-20(27)19(15-8-16(26)11-17(28)9-15)12-22(23)31-21-4-3-18(10-14(21)2-5-25(31)32)37(33,34)30-24-6-7-36-29-24/h2-13H,1H3,(H,29,30)
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UniProtKB/SwissProt

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n/an/a 9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217756
PNG
(US9212182, 697)
Show SMILES COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C26H17F4N3O5S/c1-37-23-13-15(17-10-18(26(28,29)30)14-19(27)11-17)2-5-22(23)33-21-6-4-20(12-16(21)3-7-25(33)34)39(35,36)32-24-8-9-38-31-24/h2-14H,1H3,(H,31,32)
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UniProtKB/SwissProt

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n/an/a 9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217770
PNG
(US9212182, 1023)
Show SMILES COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C25H17Cl2N3O5S/c1-34-23-13-15(17-10-18(26)14-19(27)11-17)2-5-22(23)30-21-6-4-20(12-16(21)3-7-25(30)31)36(32,33)29-24-8-9-35-28-24/h2-14H,1H3,(H,28,29)
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UniProtKB/SwissProt

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n/an/a 9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217886
PNG
(US9212182, 791)
Show SMILES CCc1cccc(c1)-c1cc(OC)c(cc1F)-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1
Show InChI InChI=1S/C27H22FN3O5S/c1-3-17-5-4-6-18(13-17)21-15-25(35-2)24(16-22(21)28)31-23-9-8-20(14-19(23)7-10-27(31)32)37(33,34)30-26-11-12-36-29-26/h4-16H,3H2,1-2H3,(H,29,30)
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UniProtKB/SwissProt

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n/an/a 9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM217889
PNG
(US9212182, 632)
Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cccc(OC(F)F)c1
Show InChI InChI=1S/C26H18F3N3O6S/c1-36-23-13-19(15-3-2-4-17(11-15)38-26(28)29)20(27)14-22(23)32-21-7-6-18(12-16(21)5-8-25(32)33)39(34,35)31-24-9-10-37-30-24/h2-14,26H,1H3,(H,30,31)
PDB

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UniProtKB/SwissProt

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DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%