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Patent code US9284333

Compile Data Set for Download or QSAR

Found 390 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218442
PNG
(US9284333, 16hb)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NC(C2CC2)C2CC2)n2CCOCc12)c1ccccc1
Show InChI InChI=1S/C25H31N3O3/c1-2-20(16-6-4-3-5-7-16)26-24(29)19-14-21(28-12-13-31-15-22(19)28)25(30)27-23(17-8-9-17)18-10-11-18/h3-7,14,17-18,20,23H,2,8-13,15H2,1H3,(H,26,29)(H,27,30)/t20-/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218253
PNG
(US9284333, 16c)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C24H27ClF3N3O3/c1-3-19(15-6-7-17(18(25)11-15)24(26,27)28)29-22(32)16-12-20(31-9-10-34-13-21(16)31)23(33)30-8-4-5-14(30)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,29,32)/t14-,19+/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218623
PNG
(US9284333, 16mb)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@@H](CC)c2ccccc2)n2CCCCc12)c1ccccc1
Show InChI InChI=1S/C28H33N3O2/c1-3-23(20-13-7-5-8-14-20)29-27(32)22-19-26(31-18-12-11-17-25(22)31)28(33)30-24(4-2)21-15-9-6-10-16-21/h5-10,13-16,19,23-24H,3-4,11-12,17-18H2,1-2H3,(H,29,32)(H,30,33)/t23-,24+/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218341
PNG
(US9284333, 16cg)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C23H27ClFN3O3/c1-3-19(15-6-7-18(25)17(24)11-15)26-22(29)16-12-20(28-9-10-31-13-21(16)28)23(30)27-8-4-5-14(27)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,26,29)/t14-,19+/m0/s1
KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218340
PNG
(US9284333, 16cf)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(s1)C(F)(F)F
Show InChI InChI=1S/C22H26F3N3O3S/c1-3-15(18-6-7-19(32-18)22(23,24)25)26-20(29)14-11-16(28-9-10-31-12-17(14)28)21(30)27-8-4-5-13(27)2/h6-7,11,13,15H,3-5,8-10,12H2,1-2H3,(H,26,29)/t13-,15+/m0/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 21n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218405
PNG
(US9284333, 16fc)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2CC)n2CCOCc12)c1ccccc1
Show InChI InChI=1S/C24H31N3O3/c1-3-18-11-8-12-26(18)24(29)21-15-19(22-16-30-14-13-27(21)22)23(28)25-20(4-2)17-9-6-5-7-10-17/h5-7,9-10,15,18,20H,3-4,8,11-14,16H2,1-2H3,(H,25,28)/t18-,20+/m0/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218535
PNG
(US9284333, 16kt)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CCSc12)c1ccccc1
Show InChI InChI=1S/C25H26FN3O2S/c1-3-21(18-7-5-4-6-8-18)28-23(30)20-15-22(29-13-14-32-25(20)29)24(31)27-16(2)17-9-11-19(26)12-10-17/h4-12,15-16,21H,3,13-14H2,1-2H3,(H,27,31)(H,28,30)/t16-,21-/m1/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 27n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218343
PNG
(US9284333, 16ci)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H27Cl2N3O3/c1-3-19(15-6-7-17(24)18(25)11-15)26-22(29)16-12-20(28-9-10-31-13-21(16)28)23(30)27-8-4-5-14(27)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,26,29)/t14-,19+/m0/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218540
PNG
(US9284333, 16ky)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CSCc12)c1ccccc1
Show InChI InChI=1S/C25H26FN3O2S/c1-3-21(18-7-5-4-6-8-18)28-24(30)20-13-22(29-15-32-14-23(20)29)25(31)27-16(2)17-9-11-19(26)12-10-17/h4-13,16,21H,3,14-15H2,1-2H3,(H,27,31)(H,28,30)/t16-,21-/m1/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 33n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218618
PNG
(US9284333, 16gk)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCCC2CC2)n2CCOCc12)c1ccccc1
Show InChI InChI=1S/C23H29N3O3/c1-2-19(17-6-4-3-5-7-17)25-22(27)18-14-20(26-12-13-29-15-21(18)26)23(28)24-11-10-16-8-9-16/h3-7,14,16,19H,2,8-13,15H2,1H3,(H,24,28)(H,25,27)/t19-/m1/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 36n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218534
PNG
(US9284333, 16ks)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCSc12)c1ccccc1
Show InChI InChI=1S/C22H27N3O2S/c1-3-18(16-9-5-4-6-10-16)23-20(26)17-14-19(25-12-13-28-22(17)25)21(27)24-11-7-8-15(24)2/h4-6,9-10,14-15,18H,3,7-8,11-13H2,1-2H3,(H,23,26)/t15-,18+/m0/s1
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GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 37n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218467
PNG
(US9284333, 16ic)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2cccc(OC)n2)n2CCOCc12)c1ccccc1
Show InChI InChI=1S/C27H32N4O4/c1-4-20(18-10-7-6-8-11-18)29-26(32)19-16-23(31-14-15-35-17-24(19)31)27(33)30-21(5-2)22-12-9-13-25(28-22)34-3/h6-13,16,20-21H,4-5,14-15,17H2,1-3H3,(H,29,32)(H,30,33)/t20-,21-/m1/s1
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GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218282
PNG
(US9284333, 16w)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1cc(F)ccc1Cl
Show InChI InChI=1S/C23H27ClFN3O3/c1-3-19(16-11-15(25)6-7-18(16)24)26-22(29)17-12-20(28-9-10-31-13-21(17)28)23(30)27-8-4-5-14(27)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,26,29)/t14-,19+/m0/s1
KEGG

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GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218463
PNG
(US9284333, 16hy)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2cnc(OC)cn2)n2CCOCc12)c1ccccc1
Show InChI InChI=1S/C26H31N5O4/c1-4-19(17-9-7-6-8-10-17)29-25(32)18-13-22(31-11-12-35-16-23(18)31)26(33)30-20(5-2)21-14-28-24(34-3)15-27-21/h6-10,13-15,19-20H,4-5,11-12,16H2,1-3H3,(H,29,32)(H,30,33)/t19-,20-/m1/s1
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UniProtKB/SwissProt

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GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 41n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218431
PNG
(US9284333, 16gl)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CCOCc12)c1ccccc1
Show InChI InChI=1S/C26H28FN3O3/c1-3-22(19-7-5-4-6-8-19)29-25(31)21-15-23(30-13-14-33-16-24(21)30)26(32)28-17(2)18-9-11-20(27)12-10-18/h4-12,15,17,22H,3,13-14,16H2,1-2H3,(H,28,32)(H,29,31)/t17-,22-/m1/s1
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UniProtKB/SwissProt

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GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 42n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218643
PNG
(US9284333, 16mz)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@@H](C)C2CC2)n2CCCCc12)c1ccccc1
Show InChI InChI=1S/C24H31N3O2/c1-3-20(18-9-5-4-6-10-18)26-23(28)19-15-22(27-14-8-7-11-21(19)27)24(29)25-16(2)17-12-13-17/h4-6,9-10,15-17,20H,3,7-8,11-14H2,1-2H3,(H,25,29)(H,26,28)/t16-,20+/m0/s1
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UniProtKB/SwissProt

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GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 42n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218279
PNG
(US9284333, 16t)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1c(F)cccc1F
Show InChI InChI=1S/C23H27F2N3O3/c1-3-18(21-16(24)7-4-8-17(21)25)26-22(29)15-12-19(28-10-11-31-13-20(15)28)23(30)27-9-5-6-14(27)2/h4,7-8,12,14,18H,3,5-6,9-11,13H2,1-2H3,(H,26,29)/t14-,18+/m0/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 44n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218547
PNG
(US9284333, 16lg)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)c2C(C)OCCn12)c1ccccc1
Show InChI InChI=1S/C27H30FN3O3/c1-4-23(20-8-6-5-7-9-20)30-27(33)24-16-22(25-18(3)34-15-14-31(24)25)26(32)29-17(2)19-10-12-21(28)13-11-19/h5-13,16-18,23H,4,14-15H2,1-3H3,(H,29,32)(H,30,33)/t17-,18?,23-/m1/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 46n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218532
PNG
(US9284333, 16kq)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)c2COCCn12)c1ccccc1
Show InChI InChI=1S/C26H28FN3O3/c1-3-22(19-7-5-4-6-8-19)29-26(32)23-15-21(24-16-33-14-13-30(23)24)25(31)28-17(2)18-9-11-20(27)12-10-18/h4-12,15,17,22H,3,13-14,16H2,1-2H3,(H,28,31)(H,29,32)/t17-,22-/m1/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 46n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218378
PNG
(US9284333, 16dw)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CCOCc12)c1cnc(OC)cn1
Show InChI InChI=1S/C25H28FN5O4/c1-4-19(20-12-28-23(34-3)13-27-20)30-24(32)18-11-21(31-9-10-35-14-22(18)31)25(33)29-15(2)16-5-7-17(26)8-6-16/h5-8,11-13,15,19H,4,9-10,14H2,1-3H3,(H,29,33)(H,30,32)/t15-,19-/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 48n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218639
PNG
(US9284333, 16mv)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C2CC2)c2ccccc2)n2CCCCc12)c1ccccc1
Show InChI InChI=1S/C29H33N3O2/c1-2-24(20-11-5-3-6-12-20)30-28(33)23-19-26(32-18-10-9-15-25(23)32)29(34)31-27(22-16-17-22)21-13-7-4-8-14-21/h3-8,11-14,19,22,24,27H,2,9-10,15-18H2,1H3,(H,30,33)(H,31,34)/t24-,27+/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 48n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218617
PNG
(US9284333, 16gj)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H]2CCc3ccccc23)n2CCOCc12)c1ccccc1
Show InChI InChI=1S/C27H29N3O3/c1-2-22(19-9-4-3-5-10-19)28-26(31)21-16-24(30-14-15-33-17-25(21)30)27(32)29-23-13-12-18-8-6-7-11-20(18)23/h3-11,16,22-23H,2,12-15,17H2,1H3,(H,28,31)(H,29,32)/t22-,23+/m1/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


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More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218361
PNG
(US9284333, 16de)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCCC2)n2CCOCc12)c1ccc(F)cc1F
Show InChI InChI=1S/C22H25F2N3O3/c1-2-18(15-6-5-14(23)11-17(15)24)25-21(28)16-12-19(22(29)26-7-3-4-8-26)27-9-10-30-13-20(16)27/h5-6,11-12,18H,2-4,7-10,13H2,1H3,(H,25,28)/t18-/m1/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218398
PNG
(US9284333, 16eu)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C(F)(F)F)n2CCOCc12)c1ccccc1
Show InChI InChI=1S/C23H26F3N3O3/c1-2-17(15-7-4-3-5-8-15)27-21(30)16-13-18(28-11-12-32-14-19(16)28)22(31)29-10-6-9-20(29)23(24,25)26/h3-5,7-8,13,17,20H,2,6,9-12,14H2,1H3,(H,27,30)/t17-,20-/m1/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


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More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218280
PNG
(US9284333, 16u)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(F)cc1Cl
Show InChI InChI=1S/C23H27ClFN3O3/c1-3-19(16-7-6-15(25)11-18(16)24)26-22(29)17-12-20(28-9-10-31-13-21(17)28)23(30)27-8-4-5-14(27)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,26,29)/t14-,19+/m0/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


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More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218370
PNG
(US9284333, 16dn)
Show SMILES C[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CCOCc12)c1ccccc1
Show InChI InChI=1S/C25H26FN3O3/c1-16(18-6-4-3-5-7-18)27-24(30)21-14-22(29-12-13-32-15-23(21)29)25(31)28-17(2)19-8-10-20(26)11-9-19/h3-11,14,16-17H,12-13,15H2,1-2H3,(H,27,30)(H,28,31)/t16-,17-/m1/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218346
PNG
(US9284333, 16cl)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1c(F)cc(cc1F)C(F)(F)F
Show InChI InChI=1S/C24H26F5N3O3/c1-3-18(21-16(25)9-14(10-17(21)26)24(27,28)29)30-22(33)15-11-19(32-7-8-35-12-20(15)32)23(34)31-6-4-5-13(31)2/h9-11,13,18H,3-8,12H2,1-2H3,(H,30,33)/t13-,18+/m0/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


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More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218566
PNG
(US9284333, 16ma)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2ccccc2)n2CCCCc12)c1ccccc1
Show InChI InChI=1S/C28H33N3O2/c1-3-23(20-13-7-5-8-14-20)29-27(32)22-19-26(31-18-12-11-17-25(22)31)28(33)30-24(4-2)21-15-9-6-10-16-21/h5-10,13-16,19,23-24H,3-4,11-12,17-18H2,1-2H3,(H,29,32)(H,30,33)/t23-,24-/m1/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218388
PNG
(US9284333, 16eg)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CCOCc12)c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C26H26F4N4O3/c1-3-20(21-9-6-17(13-31-21)26(28,29)30)33-24(35)19-12-22(34-10-11-37-14-23(19)34)25(36)32-15(2)16-4-7-18(27)8-5-16/h4-9,12-13,15,20H,3,10-11,14H2,1-2H3,(H,32,36)(H,33,35)/t15-,20-/m1/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218462
PNG
(US9284333, 16hx)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@@H](CC)c2cnccn2)n2CCOCc12)c1ccccc1
Show InChI InChI=1S/C25H29N5O3/c1-3-19(17-8-6-5-7-9-17)28-24(31)18-14-22(30-12-13-33-16-23(18)30)25(32)29-20(4-2)21-15-26-10-11-27-21/h5-11,14-15,19-20H,3-4,12-13,16H2,1-2H3,(H,28,31)(H,29,32)/t19-,20+/m1/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218622
PNG
(US9284333, 16lt)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@@H](C)c2ccc(F)cc2)n2CCCCc12)c1ccccc1
Show InChI InChI=1S/C27H30FN3O2/c1-3-23(20-9-5-4-6-10-20)30-26(32)22-17-25(31-16-8-7-11-24(22)31)27(33)29-18(2)19-12-14-21(28)15-13-19/h4-6,9-10,12-15,17-18,23H,3,7-8,11,16H2,1-2H3,(H,29,33)(H,30,32)/t18-,23+/m0/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218252
PNG
(US9284333, 16b)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1cnc(OC)c(Cl)c1
Show InChI InChI=1S/C23H29ClN4O4/c1-4-18(15-10-17(24)22(31-3)25-12-15)26-21(29)16-11-19(28-8-9-32-13-20(16)28)23(30)27-7-5-6-14(27)2/h10-12,14,18H,4-9,13H2,1-3H3,(H,26,29)/t14-,18+/m0/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218368
PNG
(US9284333, 16dl)
Show SMILES CCOC(=O)C[C@H]1CCCN1C(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CCOCc12
Show InChI InChI=1S/C25H30FN3O5/c1-3-34-23(30)13-19-5-4-10-28(19)25(32)20-14-21(29-11-12-33-15-22(20)29)24(31)27-16(2)17-6-8-18(26)9-7-17/h6-9,14,16,19H,3-5,10-13,15H2,1-2H3,(H,27,31)/t16-,19-/m1/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218276
PNG
(US9284333, 16q)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccccc1Cl
Show InChI InChI=1S/C24H30ClN3O3/c1-15(2)22(17-8-4-5-9-19(17)25)26-23(29)18-13-20(28-11-12-31-14-21(18)28)24(30)27-10-6-7-16(27)3/h4-5,8-9,13,15-16,22H,6-7,10-12,14H2,1-3H3,(H,26,29)/t16-,22+/m0/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218543
PNG
(US9284333, 16lb)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2ncccn2)c2COCCn12)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H28F3N5O3/c1-3-19(16-6-8-17(9-7-16)26(27,28)29)32-25(36)21-14-18(22-15-37-13-12-34(21)22)24(35)33-20(4-2)23-30-10-5-11-31-23/h5-11,14,19-20H,3-4,12-13,15H2,1-2H3,(H,32,36)(H,33,35)/t19-,20-/m1/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218337
PNG
(US9284333, 16cc)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(nc1Cl)C(F)(F)F
Show InChI InChI=1S/C23H26ClF3N4O3/c1-3-16(14-6-7-19(23(25,26)27)29-20(14)24)28-21(32)15-11-17(31-9-10-34-12-18(15)31)22(33)30-8-4-5-13(30)2/h6-7,11,13,16H,3-5,8-10,12H2,1-2H3,(H,28,32)/t13-,16+/m0/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218506
PNG
(US9284333, 16jq)
Show SMILES CC[C@H](NC(=O)c1cc(C(=O)N[C@H](C(C)C)c2ccc(F)cc2)c2COCCn12)c1ccccc1
Show InChI InChI=1S/C28H32FN3O3/c1-4-23(19-8-6-5-7-9-19)30-28(34)24-16-22(25-17-35-15-14-32(24)25)27(33)31-26(18(2)3)20-10-12-21(29)13-11-20/h5-13,16,18,23,26H,4,14-15,17H2,1-3H3,(H,30,34)(H,31,33)/t23-,26+/m0/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218256
PNG
(US9284333, 16f)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H28F3N3O3/c1-3-19(16-6-8-17(9-7-16)24(25,26)27)28-22(31)18-13-20(30-11-12-33-14-21(18)30)23(32)29-10-4-5-15(29)2/h6-9,13,15,19H,3-5,10-12,14H2,1-2H3,(H,28,31)/t15-,19+/m0/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218251
PNG
(US9284333, 16a)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccccc1
Show InChI InChI=1S/C23H29N3O3/c1-3-19(17-9-5-4-6-10-17)24-22(27)18-14-20(26-12-13-29-15-21(18)26)23(28)25-11-7-8-16(25)2/h4-6,9-10,14,16,19H,3,7-8,11-13,15H2,1-2H3,(H,24,27)/t16-,19+/m0/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218271
PNG
(US9284333, 16ht)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@@H](C)c2ccc(F)cc2)n2CCOCc12)c1ccccc1
Show InChI InChI=1S/C26H28FN3O3/c1-3-22(19-7-5-4-6-8-19)29-25(31)21-15-23(30-13-14-33-16-24(21)30)26(32)28-17(2)18-9-11-20(27)12-10-18/h4-12,15,17,22H,3,13-14,16H2,1-2H3,(H,28,32)(H,29,31)/t17-,22+/m0/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218342
PNG
(US9284333, 16ch)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(OC)c(Cl)c1
Show InChI InChI=1S/C24H30ClN3O4/c1-4-19(16-7-8-22(31-3)18(25)12-16)26-23(29)17-13-20(28-10-11-32-14-21(17)28)24(30)27-9-5-6-15(27)2/h7-8,12-13,15,19H,4-6,9-11,14H2,1-3H3,(H,26,29)/t15-,19+/m0/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218640
PNG
(US9284333, 16mw)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)C2CC2)n2CCCCc12)c1ccccc1
Show InChI InChI=1S/C24H31N3O2/c1-3-20(18-9-5-4-6-10-18)26-23(28)19-15-22(27-14-8-7-11-21(19)27)24(29)25-16(2)17-12-13-17/h4-6,9-10,15-17,20H,3,7-8,11-14H2,1-2H3,(H,25,29)(H,26,28)/t16-,20-/m1/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218606
PNG
(US9284333, 16cx)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCCC2)n2CCOCc12)c1ccccc1
Show InChI InChI=1S/C22H27N3O3/c1-2-18(16-8-4-3-5-9-16)23-21(26)17-14-19(22(27)24-10-6-7-11-24)25-12-13-28-15-20(17)25/h3-5,8-9,14,18H,2,6-7,10-13,15H2,1H3,(H,23,26)/t18-/m1/s1
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UniChem
US Patent
n/an/a 74n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218638
PNG
(US9284333, 16mu)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N(C)Cc2ccc(F)cc2)n2CCCCc12)c1ccccc1
Show InChI InChI=1S/C27H30FN3O2/c1-3-23(20-9-5-4-6-10-20)29-26(32)22-17-25(31-16-8-7-11-24(22)31)27(33)30(2)18-19-12-14-21(28)15-13-19/h4-6,9-10,12-15,17,23H,3,7-8,11,16,18H2,1-2H3,(H,29,32)/t23-/m1/s1
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PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218299
PNG
(US9284333, 16ap)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C23H27F3N4O3/c1-3-16(17-7-4-8-20(27-17)23(24,25)26)28-21(31)15-12-18(30-10-11-33-13-19(15)30)22(32)29-9-5-6-14(29)2/h4,7-8,12,14,16H,3,5-6,9-11,13H2,1-2H3,(H,28,31)/t14-,16+/m0/s1
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PC sid
UniChem
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n/an/a 76n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218544
PNG
(US9284333, 16ld)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCC2CC2)n2CCOCc12)c1ccccc1Cl
Show InChI InChI=1S/C22H26ClN3O3/c1-2-18(15-5-3-4-6-17(15)23)25-21(27)16-11-19(22(28)24-12-14-7-8-14)26-9-10-29-13-20(16)26/h3-6,11,14,18H,2,7-10,12-13H2,1H3,(H,24,28)(H,25,27)/t18-/m1/s1
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PC sid
UniChem
US Patent
n/an/a 80n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218568
PNG
(US9284333, 16md)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCc2nccs2)c2CCCCn12)c1ccccc1
Show InChI InChI=1S/C23H26N4O2S/c1-2-18(16-8-4-3-5-9-16)26-23(29)20-14-17(19-10-6-7-12-27(19)20)22(28)25-15-21-24-11-13-30-21/h3-5,8-9,11,13-14,18H,2,6-7,10,12,15H2,1H3,(H,25,28)(H,26,29)/t18-/m1/s1
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PC sid
UniChem
US Patent
n/an/a 80n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218536
PNG
(US9284333, 16ku)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)c2SCCn12)c1ccccc1
Show InChI InChI=1S/C25H26FN3O2S/c1-3-21(18-7-5-4-6-8-18)28-24(31)22-15-20(25-29(22)13-14-32-25)23(30)27-16(2)17-9-11-19(26)12-10-17/h4-12,15-16,21H,3,13-14H2,1-2H3,(H,27,30)(H,28,31)/t16-,21-/m1/s1
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UniChem
US Patent
n/an/a 87n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218360
PNG
(US9284333, 16db)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCCC2)n2CCOCc12)c1ccc(F)cc1Cl
Show InChI InChI=1S/C22H25ClFN3O3/c1-2-18(15-6-5-14(24)11-17(15)23)25-21(28)16-12-19(22(29)26-7-3-4-8-26)27-9-10-30-13-20(16)27/h5-6,11-12,18H,2-4,7-10,13H2,1H3,(H,25,28)/t18-/m1/s1
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PC sid
UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM218573
PNG
(US9284333, 16nh)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)c2COCCn12)c1ccccc1Cl
Show InChI InChI=1S/C23H28ClN3O3/c1-3-19(16-8-4-5-9-18(16)24)25-22(28)20-13-17(21-14-30-12-11-27(20)21)23(29)26-10-6-7-15(26)2/h4-5,8-9,13,15,19H,3,6-7,10-12,14H2,1-2H3,(H,25,28)/t15-,19+/m0/s1
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UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%