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Patent code US9290476

Compile Data Set for Download or QSAR
Found 160 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220164
PNG
(US9290476, 7)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(F)cc1)C(O)(c1cccnc1)c1cccc(Cl)c1
Show InChI InChI=1S/C29H21Cl2FN2O2/c1-36-28-25(14-18-7-10-23(32)11-8-18)27(31)24-16-20(9-12-26(24)34-28)29(35,21-5-3-13-33-17-21)19-4-2-6-22(30)15-19/h2-13,15-17,35H,14H2,1H3
PDB

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US Patent
n/an/an/a 40n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220178
PNG
(US9290476, 21)
Show SMILES COc1ccc(cn1)C(O)(c1cncn1C)c1ccc2nc(Cl)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C30H24Cl2N6O2/c1-37-18-33-17-26(37)30(39,21-7-11-27(40-2)34-16-21)20-6-10-25-23(15-20)28(31)24(29(32)36-25)14-19-4-8-22(9-5-19)38-13-3-12-35-38/h3-13,15-18,39H,14H2,1-2H3
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n/an/an/a 6.10n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220181
PNG
(US9290476, 24)
Show SMILES CCOc1nc2ccc(cc2cc1Cc1ccc(OC)cc1)C(O)(c1cncs1)c1cncn1C
Show InChI InChI=1S/C27H26N4O3S/c1-4-34-26-20(11-18-5-8-22(33-3)9-6-18)12-19-13-21(7-10-23(19)30-26)27(32,25-15-29-17-35-25)24-14-28-16-31(24)2/h5-10,12-17,32H,4,11H2,1-3H3
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n/an/an/a 750n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220185
PNG
(US9290476, 28A | US9290476, 28B | US9290476, 28C)
Show SMILES COc1nc2c(C)cc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C32H27Cl2N5O2/c1-20-15-23(32(40,28-18-35-19-38(28)2)22-7-9-24(33)10-8-22)17-26-29(34)27(31(41-3)37-30(20)26)16-21-5-11-25(12-6-21)39-14-4-13-36-39/h4-15,17-19,40H,16H2,1-3H3
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n/an/an/a 5.80n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220194
PNG
(US9290476, 37A | US9290476, 37B | US9290476, 37C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1cc2ccccc2s1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C30H22ClF3N4O2S/c1-38-16-35-15-26(38)29(39,19-8-10-25(36-14-19)30(32,33)34)18-7-9-23-21(12-18)27(31)22(28(37-23)40-2)13-20-11-17-5-3-4-6-24(17)41-20/h3-12,14-16,39H,13H2,1-2H3
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n/an/an/a 7.80n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220197
PNG
(US9290476, 40)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1ccc(cc1)C(F)(F)F)c1cccnc1
Show InChI InChI=1S/C33H24ClF3N4O2/c1-43-31-28(18-21-5-12-26(13-6-21)41-17-3-16-39-41)30(34)27-19-24(11-14-29(27)40-31)32(42,25-4-2-15-38-20-25)22-7-9-23(10-8-22)33(35,36)37/h2-17,19-20,42H,18H2,1H3
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n/an/an/a 20n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220201
PNG
(US9290476, 44)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cccnc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C32H23Cl3N4O2/c1-41-31-26(16-20-5-9-24(10-6-20)39-15-3-14-37-39)30(35)25-17-21(8-12-29(25)38-31)32(40,23-4-2-13-36-19-23)22-7-11-27(33)28(34)18-22/h2-15,17-19,40H,16H2,1H3
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n/an/an/a 15n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220217
PNG
(US9290476, 60A | US9290476, 60B | US9290476, 60C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(C1CCN(CC1)C(C)=O)c1cncn1C
Show InChI InChI=1S/C32H33ClN6O3/c1-21(40)38-15-11-23(12-16-38)32(41,29-19-34-20-37(29)2)24-7-10-28-26(18-24)30(33)27(31(36-28)42-3)17-22-5-8-25(9-6-22)39-14-4-13-35-39/h4-10,13-14,18-20,23,41H,11-12,15-17H2,1-3H3
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n/an/an/a 18n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220217
PNG
(US9290476, 60A | US9290476, 60B | US9290476, 60C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(C1CCN(CC1)C(C)=O)c1cncn1C
Show InChI InChI=1S/C32H33ClN6O3/c1-21(40)38-15-11-23(12-16-38)32(41,29-19-34-20-37(29)2)24-7-10-28-26(18-24)30(33)27(31(36-28)42-3)17-22-5-8-25(9-6-22)39-14-4-13-35-39/h4-10,13-14,18-20,23,41H,11-12,15-17H2,1-3H3
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n/an/an/a 33n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220217
PNG
(US9290476, 60A | US9290476, 60B | US9290476, 60C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(C1CCN(CC1)C(C)=O)c1cncn1C
Show InChI InChI=1S/C32H33ClN6O3/c1-21(40)38-15-11-23(12-16-38)32(41,29-19-34-20-37(29)2)24-7-10-28-26(18-24)30(33)27(31(36-28)42-3)17-22-5-8-25(9-6-22)39-14-4-13-35-39/h4-10,13-14,18-20,23,41H,11-12,15-17H2,1-3H3
PDB

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n/an/an/a 20n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220219
PNG
(US9290476, 62A | US9290476, 62B | US9290476, 62C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C29H21ClF6N4O2/c1-40-15-37-14-24(40)27(41,19-8-10-23(38-13-19)29(34,35)36)18-7-9-22-20(12-18)25(30)21(26(39-22)42-2)11-16-3-5-17(6-4-16)28(31,32)33/h3-10,12-15,41H,11H2,1-2H3
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n/an/an/a 1.5n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220221
PNG
(US9290476, 64A | US9290476, 64B | US9290476, 64C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cncn1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H24Cl2N6O2/c1-37-17-33-15-27(37)30(39,20-5-8-22(31)9-6-20)21-7-12-26-24(14-21)28(32)25(29(36-26)40-2)13-19-3-10-23(11-4-19)38-18-34-16-35-38/h3-12,14-18,39H,13H2,1-2H3
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n/an/an/a 16n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220310
PNG
(US9290476, 65B | US9290476, 65C)
Show SMILES Cc1cc(cc2c(C#N)c(Cc3ccc(cc3)-n3cccn3)c(nc12)C#N)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C33H23F3N8O/c1-20-12-23(32(45,30-18-39-19-43(30)2)22-6-9-29(40-17-22)33(34,35)36)14-26-27(15-37)25(28(16-38)42-31(20)26)13-21-4-7-24(8-5-21)44-11-3-10-41-44/h3-12,14,17-19,45H,13H2,1-2H3
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n/an/an/a 4.20n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220312
PNG
(US9290476, 66B | US9290476, 66C)
Show SMILES Cc1cc(cc2c(C#N)c(Cc3ccc(cc3)-n3cccn3)c(nc12)C#N)C(O)(c1cncn1C)c1ccc(cc1)C#N
Show InChI InChI=1S/C34H24N8O/c1-22-14-26(34(43,32-20-38-21-41(32)2)25-8-4-24(17-35)5-9-25)16-29-30(18-36)28(31(19-37)40-33(22)29)15-23-6-10-27(11-7-23)42-13-3-12-39-42/h3-14,16,20-21,43H,15H2,1-2H3
PDB

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n/an/an/a 270n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220312
PNG
(US9290476, 66B | US9290476, 66C)
Show SMILES Cc1cc(cc2c(C#N)c(Cc3ccc(cc3)-n3cccn3)c(nc12)C#N)C(O)(c1cncn1C)c1ccc(cc1)C#N
Show InChI InChI=1S/C34H24N8O/c1-22-14-26(34(43,32-20-38-21-41(32)2)25-8-4-24(17-35)5-9-25)16-29-30(18-36)28(31(19-37)40-33(22)29)15-23-6-10-27(11-7-23)42-13-3-12-39-42/h3-14,16,20-21,43H,15H2,1-2H3
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n/an/an/a 7.90n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220318
PNG
(US9290476, 70B | US9290476, 70C)
Show SMILES Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Cc3ccc(cc3)-n3cccn3)cc2c1
Show InChI InChI=1S/C31H22F3N7O/c1-40-19-36-18-29(40)30(42,24-6-10-28(37-17-24)31(32,33)34)23-5-9-26-22(15-23)14-21(27(16-35)39-26)13-20-3-7-25(8-4-20)41-12-2-11-38-41/h2-12,14-15,17-19,42H,13H2,1H3
PDB

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n/an/an/a 1.60E+4n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220320
PNG
(US9290476, 71B | US9290476, 71C)
Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(C#N)c(Cc3ccc(cc3)-n3cccn3)c(C#N)c2c1
Show InChI InChI=1S/C32H22ClN7O/c1-39-20-36-19-31(39)32(41,22-5-8-24(33)9-6-22)23-7-12-29-27(16-23)28(17-34)26(30(18-35)38-29)15-21-3-10-25(11-4-21)40-14-2-13-37-40/h2-14,16,19-20,41H,15H2,1H3
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n/an/an/a 1.60n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220322
PNG
(US9290476, 73B | US9290476, 73C)
Show SMILES COc1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C32H24F3N7O2/c1-41-19-37-18-29(41)31(43,22-7-11-28(38-17-22)32(33,34)35)21-6-10-27-24(15-21)26(16-36)25(30(40-27)44-2)14-20-4-8-23(9-5-20)42-13-3-12-39-42/h3-13,15,17-19,43H,14H2,1-2H3
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n/an/an/a 34n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220233
PNG
(US9290476, 77A | US9290476, 77B | US9290476, 77C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnnn1C)c1ccc(C)nc1C
Show InChI InChI=1S/C29H25ClF3N5O2/c1-16-5-11-23(17(2)35-16)28(39,25-15-34-37-38(25)3)20-10-12-24-21(14-20)26(30)22(27(36-24)40-4)13-18-6-8-19(9-7-18)29(31,32)33/h5-12,14-15,39H,13H2,1-4H3
PDB

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n/an/an/a 1.10n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220233
PNG
(US9290476, 77A | US9290476, 77B | US9290476, 77C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnnn1C)c1ccc(C)nc1C
Show InChI InChI=1S/C29H25ClF3N5O2/c1-16-5-11-23(17(2)35-16)28(39,25-15-34-37-38(25)3)20-10-12-24-21(14-20)26(30)22(27(36-24)40-4)13-18-6-8-19(9-7-18)29(31,32)33/h5-12,14-15,39H,13H2,1-4H3
PDB

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n/an/an/a 0.140n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220234
PNG
(US9290476, 78A | US9290476, 78B | US9290476, 78C)
Show SMILES COc1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnnn1C)c1ccc(C)nc1C
Show InChI InChI=1S/C30H25F3N6O2/c1-17-5-11-25(18(2)36-17)29(40,27-16-35-38-39(27)3)21-10-12-26-22(14-21)24(15-34)23(28(37-26)41-4)13-19-6-8-20(9-7-19)30(31,32)33/h5-12,14,16,40H,13H2,1-4H3
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n/an/an/a 120n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220234
PNG
(US9290476, 78A | US9290476, 78B | US9290476, 78C)
Show SMILES COc1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnnn1C)c1ccc(C)nc1C
Show InChI InChI=1S/C30H25F3N6O2/c1-17-5-11-25(18(2)36-17)29(40,27-16-35-38-39(27)3)21-10-12-26-22(14-21)24(15-34)23(28(37-26)41-4)13-19-6-8-20(9-7-19)30(31,32)33/h5-12,14,16,40H,13H2,1-4H3
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n/an/an/a 0.280n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220235
PNG
(US9290476, 80A | US9290476, 80B | US9290476, 80C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnnn1C)c1cnc(C)n1C
Show InChI InChI=1S/C27H24ClF3N6O2/c1-15-32-13-22(36(15)2)26(38,23-14-33-35-37(23)3)18-9-10-21-19(12-18)24(28)20(25(34-21)39-4)11-16-5-7-17(8-6-16)27(29,30)31/h5-10,12-14,38H,11H2,1-4H3
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n/an/an/a 0.140n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220247
PNG
(US9290476, 92A | US9290476, 92B | US9290476, 92C)
Show SMILES Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Cc3ccc(cc3)C(F)(F)F)c(Cl)c2c1
Show InChI InChI=1S/C31H24ClF6N5O/c1-42-17-39-16-26(42)29(44,21-8-10-25(40-15-21)31(36,37)38)20-7-9-24-22(14-20)27(32)23(28(41-24)43-11-2-12-43)13-18-3-5-19(6-4-18)30(33,34)35/h3-10,14-17,44H,2,11-13H2,1H3
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n/an/an/a 1.40n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220159
PNG
(US9290476, 2)
Show SMILES OC(c1cccnc1)(c1cccc(Cl)c1)c1ccc2nc(Cl)c(Cc3ccc(Cl)cc3)c(Cl)c2c1
Show InChI InChI=1S/C28H18Cl4N2O/c29-21-9-6-17(7-10-21)13-24-26(31)23-15-19(8-11-25(23)34-27(24)32)28(35,20-4-2-12-33-16-20)18-3-1-5-22(30)14-18/h1-12,14-16,35H,13H2
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n/an/an/a 17n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220160
PNG
(US9290476, 3)
Show SMILES OC(c1cccnc1)(c1cccc(Cl)c1)c1ccc2nc(Cl)c(Cc3ccc(F)cc3)c(Cl)c2c1
Show InChI InChI=1S/C28H18Cl3FN2O/c29-21-5-1-3-18(14-21)28(35,20-4-2-12-33-16-20)19-8-11-25-23(15-19)26(30)24(27(31)34-25)13-17-6-9-22(32)10-7-17/h1-12,14-16,35H,13H2
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n/an/an/a 32n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220166
PNG
(US9290476, 9)
Show SMILES OC(c1cncs1)(c1cccnc1)c1ccc2nc(Cl)c(Cc3ccc(Cl)cc3)c(Cl)c2c1
Show InChI InChI=1S/C25H16Cl3N3OS/c26-18-6-3-15(4-7-18)10-20-23(27)19-11-16(5-8-21(19)31-24(20)28)25(32,22-13-30-14-33-22)17-2-1-9-29-12-17/h1-9,11-14,32H,10H2
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n/an/an/a 0.830n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220174
PNG
(US9290476, 17)
Show SMILES CCN(C)c1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C33H30Cl2N6O/c1-4-39(2)32-28(18-22-6-13-26(14-7-22)41-17-5-16-37-41)31(35)27-19-24(10-15-29(27)38-32)33(42,30-20-36-21-40(30)3)23-8-11-25(34)12-9-23/h5-17,19-21,42H,4,18H2,1-3H3
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n/an/an/a 310n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220176
PNG
(US9290476, 19)
Show SMILES CCOc1nc2ccc(cc2c(Cl)c1Cc1ccccc1)C(O)(c1cncs1)c1ccc(OC)nc1
Show InChI InChI=1S/C28H24ClN3O3S/c1-3-35-27-22(13-18-7-5-4-6-8-18)26(29)21-14-19(9-11-23(21)32-27)28(33,24-16-30-17-36-24)20-10-12-25(34-2)31-15-20/h4-12,14-17,33H,3,13H2,1-2H3
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n/an/an/a 2.70n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220186
PNG
(US9290476, 29A | US9290476, 29B | US9290476, 29C)
Show SMILES COc1nc2c(C)cc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C32H26ClF3N6O2/c1-19-13-22(31(43,27-17-37-18-41(27)2)21-7-10-26(38-16-21)32(34,35)36)15-24-28(33)25(30(44-3)40-29(19)24)14-20-5-8-23(9-6-20)42-12-4-11-39-42/h4-13,15-18,43H,14H2,1-3H3
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n/an/an/a 4.80n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220186
PNG
(US9290476, 29A | US9290476, 29B | US9290476, 29C)
Show SMILES COc1nc2c(C)cc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C32H26ClF3N6O2/c1-19-13-22(31(43,27-17-37-18-41(27)2)21-7-10-26(38-16-21)32(34,35)36)15-24-28(33)25(30(44-3)40-29(19)24)14-20-5-8-23(9-6-20)42-12-4-11-39-42/h4-13,15-18,43H,14H2,1-3H3
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n/an/an/a 4.90n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220189
PNG
(US9290476, 32)
Show SMILES OC(c1cccnc1)(c1cccc(Cl)c1)c1ccc2nc(Cl)c(Cc3cccs3)c(Cl)c2c1
Show InChI InChI=1S/C26H17Cl3N2OS/c27-19-6-1-4-16(12-19)26(32,18-5-2-10-30-15-18)17-8-9-23-21(13-17)24(28)22(25(29)31-23)14-20-7-3-11-33-20/h1-13,15,32H,14H2
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n/an/an/a 33n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220196
PNG
(US9290476, 39)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1ccc(F)cc1)c1cccnc1
Show InChI InChI=1S/C32H24ClFN4O2/c1-40-31-28(18-21-5-12-26(13-6-21)38-17-3-16-36-38)30(33)27-19-23(9-14-29(27)37-31)32(39,24-4-2-15-35-20-24)22-7-10-25(34)11-8-22/h2-17,19-20,39H,18H2,1H3
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n/an/an/a 21n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220209
PNG
(US9290476, 52)
Show SMILES COc1ccc(Cc2cc3cc(ccc3nc2Cl)C(O)(c2cncs2)c2cncn2C)cc1
Show InChI InChI=1S/C25H21ClN4O2S/c1-30-14-27-12-22(30)25(31,23-13-28-15-33-23)19-5-8-21-17(11-19)10-18(24(26)29-21)9-16-3-6-20(32-2)7-4-16/h3-8,10-15,31H,9H2,1-2H3
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n/an/an/a 1.90E+3n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220212
PNG
(US9290476, 55A | US9290476, 55B | US9290476, 55C)
Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(O)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C30H23Cl2N5O2/c1-36-18-33-17-27(36)30(39,20-5-8-22(31)9-6-20)21-7-12-26-24(16-21)28(32)25(29(38)35-26)15-19-3-10-23(11-4-19)37-14-2-13-34-37/h2-14,16-18,39H,15H2,1H3,(H,35,38)
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n/an/an/a>8.10E+4n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220298
PNG
(US9290476, 58B | US9290476, 58C)
Show SMILES COc1nc2c(F)cc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C31H23ClF4N6O2/c1-41-17-37-16-26(41)30(43,19-6-9-25(38-15-19)31(34,35)36)20-13-22-27(32)23(29(44-2)40-28(22)24(33)14-20)12-18-4-7-21(8-5-18)42-11-3-10-39-42/h3-11,13-17,43H,12H2,1-2H3
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n/an/an/a 14n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220300
PNG
(US9290476, 59B | US9290476, 59C)
Show SMILES COc1cc(cc2c(Cl)c(Cc3ccc(cc3)-n3cccn3)c(OC)nc12)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C32H26ClF3N6O3/c1-41-18-37-17-27(41)31(43,20-7-10-26(38-16-20)32(34,35)36)21-14-23-28(33)24(30(45-3)40-29(23)25(15-21)44-2)13-19-5-8-22(9-6-19)42-12-4-11-39-42/h4-12,14-18,43H,13H2,1-3H3
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n/an/an/a 4.40n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220300
PNG
(US9290476, 59B | US9290476, 59C)
Show SMILES COc1cc(cc2c(Cl)c(Cc3ccc(cc3)-n3cccn3)c(OC)nc12)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C32H26ClF3N6O3/c1-41-18-37-17-27(41)31(43,20-7-10-26(38-16-20)32(34,35)36)21-14-23-28(33)24(30(45-3)40-29(23)25(15-21)44-2)13-19-5-8-22(9-6-19)42-12-4-11-39-42/h4-12,14-18,43H,13H2,1-3H3
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n/an/an/a 220n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220221
PNG
(US9290476, 64A | US9290476, 64B | US9290476, 64C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cncn1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H24Cl2N6O2/c1-37-17-33-15-27(37)30(39,20-5-8-22(31)9-6-20)21-7-12-26-24(14-21)28(32)25(29(36-26)40-2)13-19-3-10-23(11-4-19)38-18-34-16-35-38/h3-12,14-18,39H,13H2,1-2H3
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n/an/an/a 450n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220310
PNG
(US9290476, 65B | US9290476, 65C)
Show SMILES Cc1cc(cc2c(C#N)c(Cc3ccc(cc3)-n3cccn3)c(nc12)C#N)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C33H23F3N8O/c1-20-12-23(32(45,30-18-39-19-43(30)2)22-6-9-29(40-17-22)33(34,35)36)14-26-27(15-37)25(28(16-38)42-31(20)26)13-21-4-7-24(8-5-21)44-11-3-10-41-44/h3-12,14,17-19,45H,13H2,1-2H3
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n/an/an/a 140n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220326
PNG
(US9290476, 75B | US9290476, 75C)
Show SMILES CCN(CC)c1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C34H32Cl2N6O/c1-4-41(5-2)33-29(19-23-7-14-27(15-8-23)42-18-6-17-38-42)32(36)28-20-25(11-16-30(28)39-33)34(43,31-21-37-22-40(31)3)24-9-12-26(35)13-10-24/h6-18,20-22,43H,4-5,19H2,1-3H3
PDB

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n/an/an/a 8.60E+3n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220326
PNG
(US9290476, 75B | US9290476, 75C)
Show SMILES CCN(CC)c1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C34H32Cl2N6O/c1-4-41(5-2)33-29(19-23-7-14-27(15-8-23)42-18-6-17-38-42)32(36)28-20-25(11-16-30(28)39-33)34(43,31-21-37-22-40(31)3)24-9-12-26(35)13-10-24/h6-18,20-22,43H,4-5,19H2,1-3H3
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n/an/an/a 150n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220235
PNG
(US9290476, 80A | US9290476, 80B | US9290476, 80C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnnn1C)c1cnc(C)n1C
Show InChI InChI=1S/C27H24ClF3N6O2/c1-15-32-13-22(36(15)2)26(38,23-14-33-35-37(23)3)18-9-10-21-19(12-18)24(28)20(25(34-21)39-4)11-16-5-7-17(8-6-16)27(29,30)31/h5-10,12-14,38H,11H2,1-4H3
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n/an/an/a 0.110n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220235
PNG
(US9290476, 80A | US9290476, 80B | US9290476, 80C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnnn1C)c1cnc(C)n1C
Show InChI InChI=1S/C27H24ClF3N6O2/c1-15-32-13-22(36(15)2)26(38,23-14-33-35-37(23)3)18-9-10-21-19(12-18)24(28)20(25(34-21)39-4)11-16-5-7-17(8-6-16)27(29,30)31/h5-10,12-14,38H,11H2,1-4H3
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n/an/an/a 0.0260n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220236
PNG
(US9290476, 81A | US9290476, 81B | US9290476, 81C)
Show SMILES COc1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnnn1C)c1cnc(C)n1C
Show InChI InChI=1S/C28H24F3N7O2/c1-16-33-14-24(37(16)2)27(39,25-15-34-36-38(25)3)19-9-10-23-20(12-19)22(13-32)21(26(35-23)40-4)11-17-5-7-18(8-6-17)28(29,30)31/h5-10,12,14-15,39H,11H2,1-4H3
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n/an/an/a 0.120n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220342
PNG
(US9290476, 88B | US9290476, 88C)
Show SMILES Cc1ccc(c(C)n1)C(O)(c1cnnn1C)c1ccc2nc(C#N)c(Cc3ccc(cc3)C(F)(F)F)c(C#N)c2c1
Show InChI InChI=1S/C30H22F3N7O/c1-17-4-10-25(18(2)37-17)29(41,28-16-36-39-40(28)3)21-9-11-26-23(13-21)24(14-34)22(27(15-35)38-26)12-19-5-7-20(8-6-19)30(31,32)33/h4-11,13,16,41H,12H2,1-3H3
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n/an/an/a 0.0400n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220244
PNG
(US9290476, 89)
Show SMILES CCc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C1CN(C1)C(=O)OC(C)(C)C)c1cnnn1C
Show InChI InChI=1S/C31H33ClF3N5O3/c1-6-24-22(13-18-7-9-19(10-8-18)31(33,34)35)27(32)23-14-20(11-12-25(23)37-24)30(42,26-15-36-38-39(26)5)21-16-40(17-21)28(41)43-29(2,3)4/h7-12,14-15,21,42H,6,13,16-17H2,1-5H3
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n/an/an/a 0.770n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220245
PNG
(US9290476, 90A | US9290476, 90B | US9290476, 90C)
Show SMILES CCc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C1CN(C1)C(C)=O)c1cnnn1C
Show InChI InChI=1S/C28H27ClF3N5O2/c1-4-23-21(11-17-5-7-18(8-6-17)28(30,31)32)26(29)22-12-19(9-10-24(22)34-23)27(39,25-13-33-35-36(25)3)20-14-37(15-20)16(2)38/h5-10,12-13,20,39H,4,11,14-15H2,1-3H3
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n/an/an/a 0.320n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220247
PNG
(US9290476, 92A | US9290476, 92B | US9290476, 92C)
Show SMILES Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Cc3ccc(cc3)C(F)(F)F)c(Cl)c2c1
Show InChI InChI=1S/C31H24ClF6N5O/c1-42-17-39-16-26(42)29(44,21-8-10-25(40-15-21)31(36,37)38)20-7-9-24-22(14-20)27(32)23(28(41-24)43-11-2-12-43)13-18-3-5-19(6-4-18)30(33,34)35/h3-10,14-17,44H,2,11-13H2,1H3
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n/an/an/a 2.5n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220251
PNG
(US9290476, 96A | US9290476, 96B | US9290476, 96C)
Show SMILES COc1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(cc1)C#N
Show InChI InChI=1S/C31H22F3N5O2/c1-39-18-37-17-28(39)30(40,21-7-5-20(15-35)6-8-21)23-11-12-27-24(14-23)26(16-36)25(29(38-27)41-2)13-19-3-9-22(10-4-19)31(32,33)34/h3-12,14,17-18,40H,13H2,1-2H3
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n/an/an/a 1.90n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220251
PNG
(US9290476, 96A | US9290476, 96B | US9290476, 96C)
Show SMILES COc1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(cc1)C#N
Show InChI InChI=1S/C31H22F3N5O2/c1-39-18-37-17-28(39)30(40,21-7-5-20(15-35)6-8-21)23-11-12-27-24(14-23)26(16-36)25(29(38-27)41-2)13-19-3-9-22(10-4-19)31(32,33)34/h3-12,14,17-18,40H,13H2,1-2H3
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n/an/an/a 2.20n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220252
PNG
(US9290476, 97A | US9290476, 97B | US9290476, 97C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C1CN(C1)C(C)=O)c1cnnn1C
Show InChI InChI=1S/C27H25ClF3N5O3/c1-15(37)36-13-19(14-36)26(38,23-12-32-34-35(23)2)18-8-9-22-20(11-18)24(28)21(25(33-22)39-3)10-16-4-6-17(7-5-16)27(29,30)31/h4-9,11-12,19,38H,10,13-14H2,1-3H3
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n/an/an/a 0.640n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220167
PNG
(US9290476, 10)
Show SMILES OC(c1cncs1)(c1cccnc1)c1ccc2nc(Cl)c(Cc3cccc(Cl)c3)cc2c1
Show InChI InChI=1S/C25H17Cl2N3OS/c26-21-5-1-3-16(10-21)9-18-11-17-12-19(6-7-22(17)30-24(18)27)25(31,23-14-29-15-32-23)20-4-2-8-28-13-20/h1-8,10-15,31H,9H2
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n/an/an/a 99n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220168
PNG
(US9290476, 11)
Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(Cl)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C30H22Cl3N5O/c1-37-18-34-17-27(37)30(39,20-5-8-22(31)9-6-20)21-7-12-26-24(16-21)28(32)25(29(33)36-26)15-19-3-10-23(11-4-19)38-14-2-13-35-38/h2-14,16-18,39H,15H2,1H3
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n/an/an/a 75n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220172
PNG
(US9290476, 15)
Show SMILES Cn1cncc1C(O)(c1cncs1)c1ccc2nc(Cl)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C27H20Cl2N6OS/c1-34-15-30-13-23(34)27(36,24-14-31-16-37-24)18-5-8-22-20(12-18)25(28)21(26(29)33-22)11-17-3-6-19(7-4-17)35-10-2-9-32-35/h2-10,12-16,36H,11H2,1H3
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n/an/an/a 4.30n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220177
PNG
(US9290476, 20A | US9290476, 20B)
Show SMILES COc1ccc(cn1)C(O)(c1cncs1)c1ccc2nc(OC)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C30H24ClN5O3S/c1-38-27-11-7-21(16-33-27)30(37,26-17-32-18-40-26)20-6-10-25-23(15-20)28(31)24(29(35-25)39-2)14-19-4-8-22(9-5-19)36-13-3-12-34-36/h3-13,15-18,37H,14H2,1-2H3
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n/an/an/a 1.40n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220190
PNG
(US9290476, 33A | US9290476, 33B | US9290476, 33C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H25Cl2N5O2/c1-37-19-34-18-28(37)31(39,21-6-9-23(32)10-7-21)22-8-13-27-25(17-22)29(33)26(30(36-27)40-2)16-20-4-11-24(12-5-20)38-15-3-14-35-38/h3-15,17-19,39H,16H2,1-2H3
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n/an/an/a 43n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220193
PNG
(US9290476, 36A | US9290476, 36B | US9290476, 36C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1cc2ccccc2s1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H23Cl2N3O2S/c1-35-17-33-16-27(35)30(36,19-7-10-21(31)11-8-19)20-9-12-25-23(14-20)28(32)24(29(34-25)37-2)15-22-13-18-5-3-4-6-26(18)38-22/h3-14,16-17,36H,15H2,1-2H3
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n/an/an/a 400n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220212
PNG
(US9290476, 55A | US9290476, 55B | US9290476, 55C)
Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(O)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C30H23Cl2N5O2/c1-36-18-33-17-27(36)30(39,20-5-8-22(31)9-6-20)21-7-12-26-24(16-21)28(32)25(29(38)35-26)15-19-3-10-23(11-4-19)37-14-2-13-34-37/h2-14,16-18,39H,15H2,1H3,(H,35,38)
PDB

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n/an/an/a 3.50E+3n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220214
PNG
(US9290476, 57)
Show SMILES COc1nc2c(C)cc(cc2c(Cl)c1Cc1ccc(cc1)S(C)(=O)=O)C(O)(c1cncn1C)c1cncn1C
Show InChI InChI=1S/C28H28ClN5O4S/c1-17-10-19(28(35,23-13-30-15-33(23)2)24-14-31-16-34(24)3)12-21-25(29)22(27(38-4)32-26(17)21)11-18-6-8-20(9-7-18)39(5,36)37/h6-10,12-16,35H,11H2,1-5H3
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n/an/an/a 8.40n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220219
PNG
(US9290476, 62A | US9290476, 62B | US9290476, 62C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C29H21ClF6N4O2/c1-40-15-37-14-24(40)27(41,19-8-10-23(38-13-19)29(34,35)36)18-7-9-22-20(12-18)25(30)21(26(39-22)42-2)11-16-3-5-17(6-4-16)28(31,32)33/h3-10,12-15,41H,11H2,1-2H3
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n/an/an/a 9.5n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220221
PNG
(US9290476, 64A | US9290476, 64B | US9290476, 64C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cncn1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H24Cl2N6O2/c1-37-17-33-15-27(37)30(39,20-5-8-22(31)9-6-20)21-7-12-26-24(14-21)28(32)25(29(36-26)40-2)13-19-3-10-23(11-4-19)38-18-34-16-35-38/h3-12,14-18,39H,13H2,1-2H3
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n/an/an/a 63n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220225
PNG
(US9290476, 68A | US9290476, 68B | US9290476, 68C)
Show SMILES Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C33H27ClF3N7O/c1-42-20-38-19-29(42)32(45,23-7-11-28(39-18-23)33(35,36)37)22-6-10-27-25(17-22)30(34)26(31(41-27)43-13-3-14-43)16-21-4-8-24(9-5-21)44-15-2-12-40-44/h2,4-12,15,17-20,45H,3,13-14,16H2,1H3
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n/an/an/a 2.10n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


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More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM50058934
PNG
(CHEMBL3325743 | US9290476, 72C)
Show SMILES Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Cc3ccc(cc3)-n3cccn3)c(C#N)c2c1
Show InChI InChI=1S/C32H21F3N8O/c1-42-19-38-18-30(42)31(44,22-6-10-29(39-17-22)32(33,34)35)21-5-9-27-25(14-21)26(15-36)24(28(16-37)41-27)13-20-3-7-23(8-4-20)43-12-2-11-40-43/h2-12,14,17-19,44H,13H2,1H3
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n/an/an/a 0.710n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220328
PNG
(US9290476, 76B | US9290476, 76C)
Show SMILES COc1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(cc1)[N+]#[C-]
Show InChI InChI=1S/C33H25N7O2/c1-35-25-10-7-23(8-11-25)33(41,31-20-36-21-39(31)2)24-9-14-30-27(18-24)29(19-34)28(32(38-30)42-3)17-22-5-12-26(13-6-22)40-16-4-15-37-40/h4-16,18,20-21,41H,17H2,2-3H3
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n/an/an/a 76n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM50058935
PNG
(CHEMBL3358455 | US9290476, 79C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnnn1C)c1sc(C)nc1C
Show InChI InChI=1S/C27H23ClF3N5O2S/c1-14-24(39-15(2)33-14)26(37,22-13-32-35-36(22)3)18-9-10-21-19(12-18)23(28)20(25(34-21)38-4)11-16-5-7-17(8-6-16)27(29,30)31/h5-10,12-13,37H,11H2,1-4H3
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n/an/an/a 57n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220236
PNG
(US9290476, 81A | US9290476, 81B | US9290476, 81C)
Show SMILES COc1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnnn1C)c1cnc(C)n1C
Show InChI InChI=1S/C28H24F3N7O2/c1-16-33-14-24(37(16)2)27(39,25-15-34-36-38(25)3)19-9-10-23-20(12-19)22(13-32)21(26(35-23)40-4)11-17-5-7-18(8-6-17)28(29,30)31/h5-10,12,14-15,39H,11H2,1-4H3
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n/an/an/a 0.0500n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220340
PNG
(US9290476, 87B | US9290476, 87C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(N)(c1cnnn1C)c1ccc(C)nc1C
Show InChI InChI=1S/C29H26ClF3N6O/c1-16-5-11-23(17(2)36-16)28(34,25-15-35-38-39(25)3)20-10-12-24-21(14-20)26(30)22(27(37-24)40-4)13-18-6-8-19(9-7-18)29(31,32)33/h5-12,14-15H,13,34H2,1-4H3
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n/an/an/a 2.30E+3n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220245
PNG
(US9290476, 90A | US9290476, 90B | US9290476, 90C)
Show SMILES CCc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C1CN(C1)C(C)=O)c1cnnn1C
Show InChI InChI=1S/C28H27ClF3N5O2/c1-4-23-21(11-17-5-7-18(8-6-17)28(30,31)32)26(29)22-12-19(9-10-24(22)34-23)27(39,25-13-33-35-36(25)3)20-14-37(15-20)16(2)38/h5-10,12-13,20,39H,4,11,14-15H2,1-3H3
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n/an/an/a 0.560n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220248
PNG
(US9290476, 93)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnc(C)n1C)c1cnc(C)n1C
Show InChI InChI=1S/C29H27ClF3N5O2/c1-16-34-14-24(37(16)3)28(39,25-15-35-17(2)38(25)4)20-10-11-23-21(13-20)26(30)22(27(36-23)40-5)12-18-6-8-19(9-7-18)29(31,32)33/h6-11,13-15,39H,12H2,1-5H3
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n/an/an/a 0.0170n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220162
PNG
(US9290476, 5)
Show SMILES OC(c1cccnc1)(c1cccc(Cl)c1)c1ccc2nc(Cl)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C31H21Cl3N4O/c32-24-6-1-4-21(17-24)31(39,23-5-2-13-35-19-23)22-9-12-28-26(18-22)29(33)27(30(34)37-28)16-20-7-10-25(11-8-20)38-15-3-14-36-38/h1-15,17-19,39H,16H2
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220163
PNG
(US9290476, 6)
Show SMILES COc1ccc(Cc2c(Cl)nc3ccc(cc3c2Cl)C(O)(c2cccnc2)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C29H21Cl3N2O2/c1-36-23-10-7-18(8-11-23)14-25-27(31)24-16-20(9-12-26(24)34-28(25)32)29(35,21-5-3-13-33-17-21)19-4-2-6-22(30)15-19/h2-13,15-17,35H,14H2,1H3
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n/an/an/a 15n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220165
PNG
(US9290476, 8)
Show SMILES CS(=O)(=O)c1ccc(Cc2c(Cl)nc3ccc(cc3c2Cl)C(O)(c2cccnc2)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C29H21Cl3N2O3S/c1-38(36,37)23-10-7-18(8-11-23)14-25-27(31)24-16-20(9-12-26(24)34-28(25)32)29(35,21-5-3-13-33-17-21)19-4-2-6-22(30)15-19/h2-13,15-17,35H,14H2,1H3
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n/an/an/a 43n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220170
PNG
(US9290476, 13)
Show SMILES COc1ccc(Cc2c(OC)nc3ccc(cc3c2Cl)C(O)(c2cncn2C)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C29H25Cl2N3O3/c1-34-17-32-16-26(34)29(35,19-6-9-21(30)10-7-19)20-8-13-25-23(15-20)27(31)24(28(33-25)37-3)14-18-4-11-22(36-2)12-5-18/h4-13,15-17,35H,14H2,1-3H3
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n/an/an/a 31n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220190
PNG
(US9290476, 33A | US9290476, 33B | US9290476, 33C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H25Cl2N5O2/c1-37-19-34-18-28(37)31(39,21-6-9-23(32)10-7-21)22-8-13-27-25(17-22)29(33)26(30(36-27)40-2)16-20-4-11-24(12-5-20)38-15-3-14-35-38/h3-15,17-19,39H,16H2,1-2H3
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n/an/an/a 20n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220192
PNG
(US9290476, 35A | US9290476, 35B | US9290476, 35C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C31H24ClF3N6O2/c1-40-18-36-17-27(40)30(42,21-7-11-26(37-16-21)31(33,34)35)20-6-10-25-23(15-20)28(32)24(29(39-25)43-2)14-19-4-8-22(9-5-19)41-13-3-12-38-41/h3-13,15-18,42H,14H2,1-2H3
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n/an/an/a 5n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220193
PNG
(US9290476, 36A | US9290476, 36B | US9290476, 36C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1cc2ccccc2s1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H23Cl2N3O2S/c1-35-17-33-16-27(35)30(36,19-7-10-21(31)11-8-19)20-9-12-25-23(14-20)28(32)24(29(34-25)37-2)15-22-13-18-5-3-4-6-26(18)38-22/h3-14,16-17,36H,15H2,1-2H3
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n/an/an/a 40n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220194
PNG
(US9290476, 37A | US9290476, 37B | US9290476, 37C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1cc2ccccc2s1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C30H22ClF3N4O2S/c1-38-16-35-15-26(38)29(39,19-8-10-25(36-14-19)30(32,33)34)18-7-9-23-21(12-18)27(31)22(28(37-23)40-2)13-20-11-17-5-3-4-6-24(17)41-20/h3-12,14-16,39H,13H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220198
PNG
(US9290476, 41)
Show SMILES COc1ccc(cc1OC)C(O)(c1cccnc1)c1ccc2nc(OC)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C34H29ClN4O4/c1-41-30-14-10-24(20-31(30)42-2)34(40,25-6-4-15-36-21-25)23-9-13-29-27(19-23)32(35)28(33(38-29)43-3)18-22-7-11-26(12-8-22)39-17-5-16-37-39/h4-17,19-21,40H,18H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220204
PNG
(US9290476, 47)
Show SMILES COc1ccc(cc1)C(O)(c1cccnc1)c1ccc2nc(Cl)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C32H24Cl2N4O2/c1-40-26-12-7-22(8-13-26)32(39,24-4-2-15-35-20-24)23-9-14-29-27(19-23)30(33)28(31(34)37-29)18-21-5-10-25(11-6-21)38-17-3-16-36-38/h2-17,19-20,39H,18H2,1H3
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n/an/an/a 140n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220205
PNG
(US9290476, 48)
Show SMILES OC(c1cccnc1)(c1cccc(F)c1)c1ccc2nc(Cl)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C31H21Cl2FN4O/c32-29-26-18-22(31(39,23-5-2-13-35-19-23)21-4-1-6-24(34)17-21)9-12-28(26)37-30(33)27(29)16-20-7-10-25(11-8-20)38-15-3-14-36-38/h1-15,17-19,39H,16H2
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n/an/an/a 10n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220294
PNG
(US9290476, 54B | US9290476, 54C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)S(C)(=O)=O)C(O)(c1cncn1C)c1ccc(F)cc1
Show InChI InChI=1S/C29H25ClFN3O4S/c1-34-17-32-16-26(34)29(35,19-6-9-21(31)10-7-19)20-8-13-25-23(15-20)27(30)24(28(33-25)38-2)14-18-4-11-22(12-5-18)39(3,36)37/h4-13,15-17,35H,14H2,1-3H3
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n/an/an/a 840n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220298
PNG
(US9290476, 58B | US9290476, 58C)
Show SMILES COc1nc2c(F)cc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C31H23ClF4N6O2/c1-41-17-37-16-26(41)30(43,19-6-9-25(38-15-19)31(34,35)36)20-13-22-27(32)23(29(44-2)40-28(22)24(33)14-20)12-18-4-7-21(8-5-18)42-11-3-10-39-42/h3-11,13-17,43H,12H2,1-2H3
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n/an/an/a 270n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220219
PNG
(US9290476, 62A | US9290476, 62B | US9290476, 62C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C29H21ClF6N4O2/c1-40-15-37-14-24(40)27(41,19-8-10-23(38-13-19)29(34,35)36)18-7-9-22-20(12-18)25(30)21(26(39-22)42-2)11-16-3-5-17(6-4-16)28(31,32)33/h3-10,12-15,41H,11H2,1-2H3
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n/an/an/a 33n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220220
PNG
(US9290476, 63A | US9290476, 63B | US9290476, 63C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C#N)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H22Cl2N4O2/c1-35-17-33-16-26(35)29(36,20-7-10-22(30)11-8-20)21-9-12-25-23(14-21)27(31)24(28(34-25)37-2)13-18-3-5-19(15-32)6-4-18/h3-12,14,16-17,36H,13H2,1-2H3
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n/an/an/a 37n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220224
PNG
(US9290476, 67A | US9290476, 67B | US9290476, 67C)
Show SMILES CON(C)c1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C32H27ClF3N7O2/c1-41-19-37-18-28(41)31(44,22-8-12-27(38-17-22)32(34,35)36)21-7-11-26-24(16-21)29(33)25(30(40-26)42(2)45-3)15-20-5-9-23(10-6-20)43-14-4-13-39-43/h4-14,16-19,44H,15H2,1-3H3
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n/an/an/a 6.30n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220318
PNG
(US9290476, 70B | US9290476, 70C)
Show SMILES Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Cc3ccc(cc3)-n3cccn3)cc2c1
Show InChI InChI=1S/C31H22F3N7O/c1-40-19-36-18-29(40)30(42,24-6-10-28(37-17-24)31(32,33)34)23-5-9-26-22(15-23)14-21(27(16-35)39-26)13-20-3-7-25(8-4-20)41-12-2-11-38-41/h2-12,14-15,17-19,42H,13H2,1H3
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n/an/an/a 1.10E+3n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220320
PNG
(US9290476, 71B | US9290476, 71C)
Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(C#N)c(Cc3ccc(cc3)-n3cccn3)c(C#N)c2c1
Show InChI InChI=1S/C32H22ClN7O/c1-39-20-36-19-31(39)32(41,22-5-8-24(33)9-6-22)23-7-12-29-27(16-23)28(17-34)26(30(18-35)38-29)15-21-3-10-25(11-4-21)40-14-2-13-37-40/h2-14,16,19-20,41H,15H2,1H3
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n/an/an/a 130n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220233
PNG
(US9290476, 77A | US9290476, 77B | US9290476, 77C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnnn1C)c1ccc(C)nc1C
Show InChI InChI=1S/C29H25ClF3N5O2/c1-16-5-11-23(17(2)35-16)28(39,25-15-34-37-38(25)3)20-10-12-24-21(14-20)26(30)22(27(36-24)40-4)13-18-6-8-19(9-7-18)29(31,32)33/h5-12,14-15,39H,13H2,1-4H3
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n/an/an/a 320n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220234
PNG
(US9290476, 78A | US9290476, 78B | US9290476, 78C)
Show SMILES COc1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnnn1C)c1ccc(C)nc1C
Show InChI InChI=1S/C30H25F3N6O2/c1-17-5-11-25(18(2)36-17)29(40,27-16-35-38-39(27)3)21-10-12-26-22(14-21)24(15-34)23(28(37-26)41-4)13-19-6-8-20(9-7-19)30(31,32)33/h5-12,14,16,40H,13H2,1-4H3
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n/an/an/a 0.520n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220184
PNG
(US9290476, 27 | US9290476, 85)
Show SMILES Cc1cc(cc2c(Cl)c(Cc3ccc(cc3)-n3cccn3)c(Cl)nc12)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H24Cl3N5O/c1-19-14-22(31(40,27-17-35-18-38(27)2)21-6-8-23(32)9-7-21)16-25-28(33)26(30(34)37-29(19)25)15-20-4-10-24(11-5-20)39-13-3-12-36-39/h3-14,16-18,40H,15H2,1-2H3
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n/an/an/a 85n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220251
PNG
(US9290476, 96A | US9290476, 96B | US9290476, 96C)
Show SMILES COc1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(cc1)C#N
Show InChI InChI=1S/C31H22F3N5O2/c1-39-18-37-17-28(39)30(40,21-7-5-20(15-35)6-8-21)23-11-12-27-24(14-23)26(16-36)25(29(38-27)41-2)13-19-3-9-22(10-4-19)31(32,33)34/h3-12,14,17-18,40H,13H2,1-2H3
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n/an/an/a 48n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220161
PNG
(US9290476, 4)
Show SMILES OC(c1cccnc1)(c1cccc(Cl)c1)c1ccc2nc(Cl)c(Cc3cccc(Cl)c3)c(Cl)c2c1
Show InChI InChI=1S/C28H18Cl4N2O/c29-21-7-1-4-17(12-21)13-24-26(31)23-15-19(9-10-25(23)34-27(24)32)28(35,20-6-3-11-33-16-20)18-5-2-8-22(30)14-18/h1-12,14-16,35H,13H2
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n/an/an/a 7.70n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220182
PNG
(US9290476, 25)
Show SMILES CN(C)c1ccc(cc1)C(O)(c1cncn1C)c1ccc2nc(Cl)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C32H28Cl2N6O/c1-38(2)24-12-7-22(8-13-24)32(41,29-19-35-20-39(29)3)23-9-14-28-26(18-23)30(33)27(31(34)37-28)17-21-5-10-25(11-6-21)40-16-4-15-36-40/h4-16,18-20,41H,17H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220183
PNG
(US9290476, 26)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C33H31ClN6O2/c1-38(2)25-13-8-23(9-14-25)33(41,30-20-35-21-39(30)3)24-10-15-29-27(19-24)31(34)28(32(37-29)42-4)18-22-6-11-26(12-7-22)40-17-5-16-36-40/h5-17,19-21,41H,18H2,1-4H3
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n/an/an/a 220n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220186
PNG
(US9290476, 29A | US9290476, 29B | US9290476, 29C)
Show SMILES COc1nc2c(C)cc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C32H26ClF3N6O2/c1-19-13-22(31(43,27-17-37-18-41(27)2)21-7-10-26(38-16-21)32(34,35)36)15-24-28(33)25(30(44-3)40-29(19)24)14-20-5-8-23(9-6-20)42-12-4-11-39-42/h4-13,15-18,43H,14H2,1-3H3
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n/an/an/a 93n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220188
PNG
(US9290476, 31)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)S(C)(=O)=O)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H25Cl2N3O4S/c1-34-17-32-16-26(34)29(35,19-6-9-21(30)10-7-19)20-8-13-25-23(15-20)27(31)24(28(33-25)38-2)14-18-4-11-22(12-5-18)39(3,36)37/h4-13,15-17,35H,14H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220190
PNG
(US9290476, 33A | US9290476, 33B | US9290476, 33C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H25Cl2N5O2/c1-37-19-34-18-28(37)31(39,21-6-9-23(32)10-7-21)22-8-13-27-25(17-22)29(33)26(30(36-27)40-2)16-20-4-11-24(12-5-20)38-15-3-14-35-38/h3-15,17-19,39H,16H2,1-2H3
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n/an/an/a 810n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220194
PNG
(US9290476, 37A | US9290476, 37B | US9290476, 37C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1cc2ccccc2s1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C30H22ClF3N4O2S/c1-38-16-35-15-26(38)29(39,19-8-10-25(36-14-19)30(32,33)34)18-7-9-23-21(12-18)27(31)22(28(37-23)40-2)13-20-11-17-5-3-4-6-24(17)41-20/h3-12,14-16,39H,13H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220202
PNG
(US9290476, 45)
Show SMILES OC(c1ccc(Cl)cc1)(c1cccnc1)c1ccc2nc(Cl)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C31H21Cl3N4O/c32-24-9-6-21(7-10-24)31(39,23-3-1-14-35-19-23)22-8-13-28-26(18-22)29(33)27(30(34)37-28)17-20-4-11-25(12-5-20)38-16-2-15-36-38/h1-16,18-19,39H,17H2
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n/an/an/a 68n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220208
PNG
(US9290476, 51)
Show SMILES CNC(=O)c1nc2ccc(cc2c(c1Cc1ccccc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(F)cc1
Show InChI InChI=1S/C30H24F4N4O2/c1-35-28(39)27-23(14-18-6-4-3-5-7-18)26(30(32,33)34)22-15-20(10-13-24(22)37-27)29(40,25-16-36-17-38(25)2)19-8-11-21(31)12-9-19/h3-13,15-17,40H,14H2,1-2H3,(H,35,39)
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n/an/an/a 1.10E+3n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220294
PNG
(US9290476, 54B | US9290476, 54C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)S(C)(=O)=O)C(O)(c1cncn1C)c1ccc(F)cc1
Show InChI InChI=1S/C29H25ClFN3O4S/c1-34-17-32-16-26(34)29(35,19-6-9-21(31)10-7-19)20-8-13-25-23(15-20)27(30)24(28(33-25)38-2)14-18-4-11-22(12-5-18)39(3,36)37/h4-13,15-17,35H,14H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220220
PNG
(US9290476, 63A | US9290476, 63B | US9290476, 63C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C#N)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H22Cl2N4O2/c1-35-17-33-16-26(35)29(36,20-7-10-22(30)11-8-20)21-9-12-25-23(14-21)27(31)24(28(34-25)37-2)13-18-3-5-19(15-32)6-4-18/h3-12,14,16-17,36H,13H2,1-2H3
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n/an/an/a 6.20n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220224
PNG
(US9290476, 67A | US9290476, 67B | US9290476, 67C)
Show SMILES CON(C)c1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C32H27ClF3N7O2/c1-41-19-37-18-28(41)31(44,22-8-12-27(38-17-22)32(34,35)36)21-7-11-26-24(16-21)29(33)25(30(40-26)42(2)45-3)15-20-5-9-23(10-6-20)43-14-4-13-39-43/h4-14,16-19,44H,15H2,1-3H3
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n/an/an/a 18n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220224
PNG
(US9290476, 67A | US9290476, 67B | US9290476, 67C)
Show SMILES CON(C)c1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C32H27ClF3N7O2/c1-41-19-37-18-28(41)31(44,22-8-12-27(38-17-22)32(34,35)36)21-7-11-26-24(16-21)29(33)25(30(40-26)42(2)45-3)15-20-5-9-23(10-6-20)43-14-4-13-39-43/h4-14,16-19,44H,15H2,1-3H3
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n/an/an/a 57n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220225
PNG
(US9290476, 68A | US9290476, 68B | US9290476, 68C)
Show SMILES Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C33H27ClF3N7O/c1-42-20-38-19-29(42)32(45,23-7-11-28(39-18-23)33(35,36)37)22-6-10-27-25(17-22)30(34)26(31(41-27)43-13-3-14-43)16-21-4-8-24(9-5-21)44-15-2-12-40-44/h2,4-12,15,17-20,45H,3,13-14,16H2,1H3
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n/an/an/a 8.30n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220324
PNG
(US9290476, 74B | US9290476, 74C)
Show SMILES CCN(CC)c1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C35H31F3N8O/c1-4-45(5-2)33-28(17-23-7-11-26(12-8-23)46-16-6-15-42-46)29(19-39)27-18-24(9-13-30(27)43-33)34(47,32-21-40-22-44(32)3)25-10-14-31(41-20-25)35(36,37)38/h6-16,18,20-22,47H,4-5,17H2,1-3H3
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n/an/an/a 1.30E+3n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220342
PNG
(US9290476, 88B | US9290476, 88C)
Show SMILES Cc1ccc(c(C)n1)C(O)(c1cnnn1C)c1ccc2nc(C#N)c(Cc3ccc(cc3)C(F)(F)F)c(C#N)c2c1
Show InChI InChI=1S/C30H22F3N7O/c1-17-4-10-25(18(2)37-17)29(41,28-16-36-39-40(28)3)21-9-11-26-23(13-21)24(14-34)22(27(15-35)38-26)12-19-5-7-20(8-6-19)30(31,32)33/h4-11,13,16,41H,12H2,1-3H3
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n/an/an/a 29n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220245
PNG
(US9290476, 90A | US9290476, 90B | US9290476, 90C)
Show SMILES CCc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C1CN(C1)C(C)=O)c1cnnn1C
Show InChI InChI=1S/C28H27ClF3N5O2/c1-4-23-21(11-17-5-7-18(8-6-17)28(30,31)32)26(29)22-12-19(9-10-24(22)34-23)27(39,25-13-33-35-36(25)3)20-14-37(15-20)16(2)38/h5-10,12-13,20,39H,4,11,14-15H2,1-3H3
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n/an/an/a 0.440n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220246
PNG
(US9290476, 91A | US9290476, 91B | US9290476, 91C)
Show SMILES CCc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C1CN(C1)S(C)(=O)=O)c1cnnn1C
Show InChI InChI=1S/C27H27ClF3N5O3S/c1-4-22-20(11-16-5-7-17(8-6-16)27(29,30)31)25(28)21-12-18(9-10-23(21)33-22)26(37,24-13-32-34-35(24)2)19-14-36(15-19)40(3,38)39/h5-10,12-13,19,37H,4,11,14-15H2,1-3H3
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n/an/an/a 0.25n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220246
PNG
(US9290476, 91A | US9290476, 91B | US9290476, 91C)
Show SMILES CCc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C1CN(C1)S(C)(=O)=O)c1cnnn1C
Show InChI InChI=1S/C27H27ClF3N5O3S/c1-4-22-20(11-16-5-7-17(8-6-16)27(29,30)31)25(28)21-12-18(9-10-23(21)33-22)26(37,24-13-32-34-35(24)2)19-14-36(15-19)40(3,38)39/h5-10,12-13,19,37H,4,11,14-15H2,1-3H3
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n/an/an/a 6.10n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220171
PNG
(US9290476, 14)
Show SMILES CCOc1nc2ccc(cc2c(Cl)c1Cc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H25Cl2N3O2/c1-3-36-28-24(15-19-7-5-4-6-8-19)27(31)23-16-21(11-14-25(23)33-28)29(35,26-17-32-18-34(26)2)20-9-12-22(30)13-10-20/h4-14,16-18,35H,3,15H2,1-2H3
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n/an/an/a 91n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220179
PNG
(US9290476, 22)
Show SMILES COc1ccc(cn1)C(O)(c1cncn1C)c1ccc2nc(OC)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C31H27ClN6O3/c1-37-19-33-18-27(37)31(39,22-8-12-28(40-2)34-17-22)21-7-11-26-24(16-21)29(32)25(30(36-26)41-3)15-20-5-9-23(10-6-20)38-14-4-13-35-38/h4-14,16-19,39H,15H2,1-3H3
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n/an/an/a 2.80n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220184
PNG
(US9290476, 27 | US9290476, 85)
Show SMILES Cc1cc(cc2c(Cl)c(Cc3ccc(cc3)-n3cccn3)c(Cl)nc12)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H24Cl3N5O/c1-19-14-22(31(40,27-17-35-18-38(27)2)21-6-8-23(32)9-7-21)16-25-28(33)26(30(34)37-29(19)25)15-20-4-10-24(11-5-20)39-13-3-12-36-39/h3-14,16-18,40H,15H2,1-2H3
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n/an/an/a 85n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220185
PNG
(US9290476, 28A | US9290476, 28B | US9290476, 28C)
Show SMILES COc1nc2c(C)cc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C32H27Cl2N5O2/c1-20-15-23(32(40,28-18-35-19-38(28)2)22-7-9-24(33)10-8-22)17-26-29(34)27(31(41-3)37-30(20)26)16-21-5-11-25(12-6-21)39-14-4-13-36-39/h4-15,17-19,40H,16H2,1-3H3
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n/an/an/a 1.60E+3n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220187
PNG
(US9290476, 30)
Show SMILES Cn1cncc1C(O)(c1cncn1C)c1ccc2nc(Cl)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C28H23Cl2N7O/c1-35-16-31-14-24(35)28(38,25-15-32-17-36(25)2)19-6-9-23-21(13-19)26(29)22(27(30)34-23)12-18-4-7-20(8-5-18)37-11-3-10-33-37/h3-11,13-17,38H,12H2,1-2H3
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n/an/an/a 2.20n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220192
PNG
(US9290476, 35A | US9290476, 35B | US9290476, 35C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C31H24ClF3N6O2/c1-40-18-36-17-27(40)30(42,21-7-11-26(37-16-21)31(33,34)35)20-6-10-25-23(15-20)28(32)24(29(39-25)43-2)14-19-4-8-22(9-5-19)41-13-3-12-38-41/h3-13,15-18,42H,14H2,1-2H3
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n/an/an/a 70n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220200
PNG
(US9290476, 43)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cn(C)cn1)c1ccc(F)cc1
Show InChI InChI=1S/C31H25ClFN5O2/c1-37-18-28(34-19-37)31(39,21-6-9-23(33)10-7-21)22-8-13-27-25(17-22)29(32)26(30(36-27)40-2)16-20-4-11-24(12-5-20)38-15-3-14-35-38/h3-15,17-19,39H,16H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220203
PNG
(US9290476, 46)
Show SMILES OC(c1ccc(F)cc1)(c1cccnc1)c1ccc2nc(Cl)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C31H21Cl2FN4O/c32-29-26-18-22(31(39,23-3-1-14-35-19-23)21-6-9-24(34)10-7-21)8-13-28(26)37-30(33)27(29)17-20-4-11-25(12-5-20)38-16-2-15-36-38/h1-16,18-19,39H,17H2
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n/an/an/a 22n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220212
PNG
(US9290476, 55A | US9290476, 55B | US9290476, 55C)
Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(O)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C30H23Cl2N5O2/c1-36-18-33-17-27(36)30(39,20-5-8-22(31)9-6-20)21-7-12-26-24(16-21)28(32)25(29(38)35-26)15-19-3-10-23(11-4-19)37-14-2-13-34-37/h2-14,16-18,39H,15H2,1H3,(H,35,38)
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n/an/an/a 7.60E+3n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220238
PNG
(US9290476, 83A | US9290476, 83B | US9290476, 83C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(C1CCN(CC1)C(C)=O)c1ccccc1
Show InChI InChI=1S/C34H33ClN4O3/c1-23(40)38-19-15-26(16-20-38)34(41,25-7-4-3-5-8-25)27-11-14-31-29(22-27)32(35)30(33(37-31)42-2)21-24-9-12-28(13-10-24)39-18-6-17-36-39/h3-14,17-18,22,26,41H,15-16,19-21H2,1-2H3
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n/an/an/a 77n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220340
PNG
(US9290476, 87B | US9290476, 87C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(N)(c1cnnn1C)c1ccc(C)nc1C
Show InChI InChI=1S/C29H26ClF3N6O/c1-16-5-11-23(17(2)36-16)28(34,25-15-35-38-39(25)3)20-10-12-24-21(14-20)26(30)22(27(37-24)40-4)13-18-6-8-19(9-7-18)29(31,32)33/h5-12,14-15H,13,34H2,1-4H3
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n/an/an/a 1.30n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220250
PNG
(US9290476, 95)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H22Cl2F3N3O2/c1-37-16-35-15-25(37)28(38,18-7-10-21(30)11-8-18)20-9-12-24-22(14-20)26(31)23(27(36-24)39-2)13-17-3-5-19(6-4-17)29(32,33)34/h3-12,14-16,38H,13H2,1-2H3
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n/an/an/a 18n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220173
PNG
(US9290476, 16)
Show SMILES CCOc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncs1)c1cncn1C
Show InChI InChI=1S/C29H25ClN6O2S/c1-3-38-28-23(13-19-5-8-21(9-6-19)36-12-4-11-33-36)27(30)22-14-20(7-10-24(22)34-28)29(37,26-16-32-18-39-26)25-15-31-17-35(25)2/h4-12,14-18,37H,3,13H2,1-2H3
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n/an/an/a 6.60n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220175
PNG
(US9290476, 18)
Show SMILES COc1ccc(cn1)C(O)(c1cncs1)c1ccc2nc(Cl)c(Cc3ccccc3)c(Cl)c2c1
Show InChI InChI=1S/C26H19Cl2N3O2S/c1-33-23-10-8-18(13-30-23)26(32,22-14-29-15-34-22)17-7-9-21-19(12-17)24(27)20(25(28)31-21)11-16-5-3-2-4-6-16/h2-10,12-15,32H,11H2,1H3
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n/an/an/a 4.5n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220177
PNG
(US9290476, 20A | US9290476, 20B)
Show SMILES COc1ccc(cn1)C(O)(c1cncs1)c1ccc2nc(OC)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C30H24ClN5O3S/c1-38-27-11-7-21(16-33-27)30(37,26-17-32-18-40-26)20-6-10-25-23(15-20)28(31)24(29(35-25)39-2)14-19-4-8-22(9-5-19)36-13-3-12-34-36/h3-13,15-18,37H,14H2,1-2H3
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n/an/an/a 3.80n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


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More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220180
PNG
(US9290476, 23)
Show SMILES Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(Cl)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C30H21Cl2F3N6O/c1-40-17-36-16-26(40)29(42,20-6-10-25(37-15-20)30(33,34)35)19-5-9-24-22(14-19)27(31)23(28(32)39-24)13-18-3-7-21(8-4-18)41-12-2-11-38-41/h2-12,14-17,42H,13H2,1H3
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n/an/an/a 4n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220185
PNG
(US9290476, 28A | US9290476, 28B | US9290476, 28C)
Show SMILES COc1nc2c(C)cc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C32H27Cl2N5O2/c1-20-15-23(32(40,28-18-35-19-38(28)2)22-7-9-24(33)10-8-22)17-26-29(34)27(31(41-3)37-30(20)26)16-21-5-11-25(12-6-21)39-14-4-13-36-39/h4-15,17-19,40H,16H2,1-3H3
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n/an/an/a 53n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220192
PNG
(US9290476, 35A | US9290476, 35B | US9290476, 35C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C31H24ClF3N6O2/c1-40-18-36-17-27(40)30(42,21-7-11-26(37-16-21)31(33,34)35)20-6-10-25-23(15-20)28(32)24(29(39-25)43-2)14-19-4-8-22(9-5-19)41-13-3-12-38-41/h3-13,15-18,42H,14H2,1-2H3
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n/an/an/a 8n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220195
PNG
(US9290476, 38)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(C1CCN(CC1)C(C)=O)c1ccc(F)cc1
Show InChI InChI=1S/C34H32ClFN4O3/c1-22(41)39-18-14-25(15-19-39)34(42,24-6-9-27(36)10-7-24)26-8-13-31-29(21-26)32(35)30(33(38-31)43-2)20-23-4-11-28(12-5-23)40-17-3-16-37-40/h3-13,16-17,21,25,42H,14-15,18-20H2,1-2H3
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n/an/an/a 3.90n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220206
PNG
(US9290476, 49)
Show SMILES Cn1cc(cn1)C(O)(c1ccc(Cl)cc1)c1ccc2nc(Cl)c(Cc3ccccc3)c(Cl)c2c1
Show InChI InChI=1S/C27H20Cl3N3O/c1-33-16-20(15-31-33)27(34,18-7-10-21(28)11-8-18)19-9-12-24-22(14-19)25(29)23(26(30)32-24)13-17-5-3-2-4-6-17/h2-12,14-16,34H,13H2,1H3
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n/an/an/a 330n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220225
PNG
(US9290476, 68A | US9290476, 68B | US9290476, 68C)
Show SMILES Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Cc3ccc(cc3)-n3cccn3)c(Cl)c2c1
Show InChI InChI=1S/C33H27ClF3N7O/c1-42-20-38-19-29(42)32(45,23-7-11-28(39-18-23)33(35,36)37)22-6-10-27-25(17-22)30(34)26(31(41-27)43-13-3-14-43)16-21-4-8-24(9-5-21)44-15-2-12-40-44/h2,4-12,15,17-20,45H,3,13-14,16H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220322
PNG
(US9290476, 73B | US9290476, 73C)
Show SMILES COc1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C32H24F3N7O2/c1-41-19-37-18-29(41)31(43,22-7-11-28(38-17-22)32(33,34)35)21-6-10-27-24(15-21)26(16-36)25(30(40-27)44-2)14-20-4-8-23(9-5-20)42-13-3-12-39-42/h3-13,15,17-19,43H,14H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220236
PNG
(US9290476, 81A | US9290476, 81B | US9290476, 81C)
Show SMILES COc1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnnn1C)c1cnc(C)n1C
Show InChI InChI=1S/C28H24F3N7O2/c1-16-33-14-24(37(16)2)27(39,25-15-34-36-38(25)3)19-9-10-23-20(12-19)22(13-32)21(26(35-23)40-4)11-17-5-7-18(8-6-17)28(29,30)31/h5-10,12,14-15,39H,11H2,1-4H3
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n/an/an/a 0.120n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220237
PNG
(US9290476, 82)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnnn1C)c1oc(C)nc1C
Show InChI InChI=1S/C27H23ClF3N5O3/c1-14-24(39-15(2)33-14)26(37,22-13-32-35-36(22)3)18-9-10-21-19(12-18)23(28)20(25(34-21)38-4)11-16-5-7-17(8-6-16)27(29,30)31/h5-10,12-13,37H,11H2,1-4H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220238
PNG
(US9290476, 83A | US9290476, 83B | US9290476, 83C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(C1CCN(CC1)C(C)=O)c1ccccc1
Show InChI InChI=1S/C34H33ClN4O3/c1-23(40)38-19-15-26(16-20-38)34(41,25-7-4-3-5-8-25)27-11-14-31-29(22-27)32(35)30(33(37-31)42-2)21-24-9-12-28(13-10-24)39-18-6-17-36-39/h3-14,17-18,22,26,41H,15-16,19-21H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220252
PNG
(US9290476, 97A | US9290476, 97B | US9290476, 97C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C1CN(C1)C(C)=O)c1cnnn1C
Show InChI InChI=1S/C27H25ClF3N5O3/c1-15(37)36-13-19(14-36)26(38,23-12-32-34-35(23)2)18-8-9-22-20(11-18)24(28)21(25(33-22)39-3)10-16-4-6-17(7-5-16)27(29,30)31/h4-9,11-12,19,38H,10,13-14H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM50058844
PNG
(CHEMBL3325741 | US9290476, 1)
Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(Cl)c(Cc3ccccc3)c(Cl)c2c1
Show InChI InChI=1S/C27H20Cl3N3O/c1-33-16-31-15-24(33)27(34,18-7-10-20(28)11-8-18)19-9-12-23-21(14-19)25(29)22(26(30)32-23)13-17-5-3-2-4-6-17/h2-12,14-16,34H,13H2,1H3
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n/an/an/a 18n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220169
PNG
(US9290476, 12)
Show SMILES COc1ccc(Cc2c(Cl)nc3ccc(cc3c2Cl)C(O)(c2cncn2C)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C28H22Cl3N3O2/c1-34-16-32-15-25(34)28(35,18-5-8-20(29)9-6-18)19-7-12-24-22(14-19)26(30)23(27(31)33-24)13-17-3-10-21(36-2)11-4-17/h3-12,14-16,35H,13H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220188
PNG
(US9290476, 31)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)S(C)(=O)=O)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H25Cl2N3O4S/c1-34-17-32-16-26(34)29(35,19-6-9-21(30)10-7-19)20-8-13-25-23(15-20)27(31)24(28(33-25)38-2)14-18-4-11-22(12-5-18)39(3,36)37/h4-13,15-17,35H,14H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220191
PNG
(US9290476, 34)
Show SMILES COc1nc2ccc(cc2c(OC)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C32H28ClN5O3/c1-37-20-34-19-29(37)32(39,22-7-10-24(33)11-8-22)23-9-14-28-26(18-23)30(40-2)27(31(36-28)41-3)17-21-5-12-25(13-6-21)38-16-4-15-35-38/h4-16,18-20,39H,17H2,1-3H3
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JANSSEN PHARMACEUTICA NV

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Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220193
PNG
(US9290476, 36A | US9290476, 36B | US9290476, 36C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1cc2ccccc2s1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H23Cl2N3O2S/c1-35-17-33-16-27(35)30(36,19-7-10-21(31)11-8-19)20-9-12-25-23(14-20)28(32)24(29(34-25)37-2)15-22-13-18-5-3-4-6-26(18)38-22/h3-14,16-17,36H,15H2,1-2H3
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JANSSEN PHARMACEUTICA NV

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Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220199
PNG
(US9290476, 42)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1ccc(cc1)N(C)C)c1cccnc1
Show InChI InChI=1S/C34H30ClN5O2/c1-39(2)27-14-9-24(10-15-27)34(41,26-6-4-17-36-22-26)25-11-16-31-29(21-25)32(35)30(33(38-31)42-3)20-23-7-12-28(13-8-23)40-19-5-18-37-40/h4-19,21-22,41H,20H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220207
PNG
(US9290476, 50)
Show SMILES Cc1nc2ccc(cc2c(C)c1Cc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H26ClN3O/c1-19-25(15-21-7-5-4-6-8-21)20(2)32-27-14-11-23(16-26(19)27)29(34,28-17-31-18-33(28)3)22-9-12-24(30)13-10-22/h4-14,16-18,34H,15H2,1-3H3
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JANSSEN PHARMACEUTICA NV

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Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220210
PNG
(US9290476, 53)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)S(C)(=O)=O)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C29H24ClF3N4O4S/c1-37-16-34-15-25(37)28(38,19-7-11-24(35-14-19)29(31,32)33)18-6-10-23-21(13-18)26(30)22(27(36-23)41-2)12-17-4-8-20(9-5-17)42(3,39)40/h4-11,13-16,38H,12H2,1-3H3
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JANSSEN PHARMACEUTICA NV

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Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220213
PNG
(US9290476, 56)
Show SMILES COc1nc2c(C)cc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1cncn1C
Show InChI InChI=1S/C30H28ClN7O2/c1-19-12-21(30(39,25-15-32-17-36(25)2)26-16-33-18-37(26)3)14-23-27(31)24(29(40-4)35-28(19)23)13-20-6-8-22(9-7-20)38-11-5-10-34-38/h5-12,14-18,39H,13H2,1-4H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220218
PNG
(US9290476, 61)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cnnn1C)c1cnnn1C
Show InChI InChI=1S/C27H24ClN9O2/c1-35-23(15-29-33-35)27(38,24-16-30-34-36(24)2)18-7-10-22-20(14-18)25(28)21(26(32-22)39-3)13-17-5-8-19(9-6-17)37-12-4-11-31-37/h4-12,14-16,38H,13H2,1-3H3
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n/an/an/a 5n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220220
PNG
(US9290476, 63A | US9290476, 63B | US9290476, 63C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C#N)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H22Cl2N4O2/c1-35-17-33-16-26(35)29(36,20-7-10-22(30)11-8-20)21-9-12-25-23(14-21)27(31)24(28(34-25)37-2)13-18-3-5-19(15-32)6-4-18/h3-12,14,16-17,36H,13H2,1-2H3
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n/an/an/a 350n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220226
PNG
(US9290476, 69)
Show SMILES COc1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C32H25ClN6O2/c1-38-20-35-19-30(38)32(40,22-6-9-24(33)10-7-22)23-8-13-29-26(17-23)28(18-34)27(31(37-29)41-2)16-21-4-11-25(12-5-21)39-15-3-14-36-39/h3-15,17,19-20,40H,16H2,1-2H3
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n/an/an/a 50n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM50058934
PNG
(CHEMBL3325743 | US9290476, 72C)
Show SMILES Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Cc3ccc(cc3)-n3cccn3)c(C#N)c2c1
Show InChI InChI=1S/C32H21F3N8O/c1-42-19-38-18-30(42)31(44,22-6-10-29(39-17-22)32(33,34)35)21-5-9-27-25(14-21)26(15-36)24(28(16-37)41-27)13-20-3-7-23(8-4-20)43-12-2-11-40-43/h2-12,14,17-19,44H,13H2,1H3
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n/an/an/a 7.10n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220324
PNG
(US9290476, 74B | US9290476, 74C)
Show SMILES CCN(CC)c1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C35H31F3N8O/c1-4-45(5-2)33-28(17-23-7-11-26(12-8-23)46-16-6-15-42-46)29(19-39)27-18-24(9-13-30(27)43-33)34(47,32-21-40-22-44(32)3)25-10-14-31(41-20-25)35(36,37)38/h6-16,18,20-22,47H,4-5,17H2,1-3H3
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n/an/an/a 2.10E+4n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220328
PNG
(US9290476, 76B | US9290476, 76C)
Show SMILES COc1nc2ccc(cc2c(C#N)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(cc1)[N+]#[C-]
Show InChI InChI=1S/C33H25N7O2/c1-35-25-10-7-23(8-11-25)33(41,31-20-36-21-39(31)2)24-9-14-30-27(18-24)29(19-34)28(32(38-30)42-3)17-22-5-12-26(13-6-22)40-16-4-15-37-40/h4-16,18,20-21,41H,17H2,2-3H3
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n/an/an/a 15n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM50058935
PNG
(CHEMBL3358455 | US9290476, 79C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(c1cnnn1C)c1sc(C)nc1C
Show InChI InChI=1S/C27H23ClF3N5O2S/c1-14-24(39-15(2)33-14)26(37,22-13-32-35-36(22)3)18-9-10-21-19(12-18)23(28)20(25(34-21)38-4)11-16-5-7-17(8-6-16)27(29,30)31/h5-10,12-13,37H,11H2,1-4H3
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n/an/an/a 0.0240n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220238
PNG
(US9290476, 83A | US9290476, 83B | US9290476, 83C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(C1CCN(CC1)C(C)=O)c1ccccc1
Show InChI InChI=1S/C34H33ClN4O3/c1-23(40)38-19-15-26(16-20-38)34(41,25-7-4-3-5-8-25)27-11-14-31-29(22-27)32(35)30(33(37-31)42-2)21-24-9-12-28(13-10-24)39-18-6-17-36-39/h3-14,17-18,22,26,41H,15-16,19-21H2,1-2H3
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n/an/an/a 12n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220246
PNG
(US9290476, 91A | US9290476, 91B | US9290476, 91C)
Show SMILES CCc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C1CN(C1)S(C)(=O)=O)c1cnnn1C
Show InChI InChI=1S/C27H27ClF3N5O3S/c1-4-22-20(11-16-5-7-17(8-6-16)27(29,30)31)25(28)21-12-18(9-10-23(21)33-22)26(37,24-13-32-34-35(24)2)19-14-36(15-19)40(3,38)39/h5-10,12-13,19,37H,4,11,14-15H2,1-3H3
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n/an/an/a 0.230n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220247
PNG
(US9290476, 92A | US9290476, 92B | US9290476, 92C)
Show SMILES Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Cc3ccc(cc3)C(F)(F)F)c(Cl)c2c1
Show InChI InChI=1S/C31H24ClF6N5O/c1-42-17-39-16-26(42)29(44,21-8-10-25(40-15-21)31(36,37)38)20-7-9-24-22(14-20)27(32)23(28(41-24)43-11-2-12-43)13-18-3-5-19(6-4-18)30(33,34)35/h3-10,14-17,44H,2,11-13H2,1H3
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n/an/an/a 12n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220249
PNG
(US9290476, 94A | US9290476, 94B | US9290476, 94C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(nc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C28H20ClF6N5O2/c1-40-14-36-13-23(40)26(41,17-5-8-22(38-12-17)28(33,34)35)16-4-6-20-18(10-16)24(29)19(25(39-20)42-2)9-15-3-7-21(37-11-15)27(30,31)32/h3-8,10-14,41H,9H2,1-2H3
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n/an/an/a 12n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220249
PNG
(US9290476, 94A | US9290476, 94B | US9290476, 94C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(nc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C28H20ClF6N5O2/c1-40-14-36-13-23(40)26(41,17-5-8-22(38-12-17)28(33,34)35)16-4-6-20-18(10-16)24(29)19(25(39-20)42-2)9-15-3-7-21(37-11-15)27(30,31)32/h3-8,10-14,41H,9H2,1-2H3
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n/an/an/a 98n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220249
PNG
(US9290476, 94A | US9290476, 94B | US9290476, 94C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(nc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C28H20ClF6N5O2/c1-40-14-36-13-23(40)26(41,17-5-8-22(38-12-17)28(33,34)35)16-4-6-20-18(10-16)24(29)19(25(39-20)42-2)9-15-3-7-21(37-11-15)27(30,31)32/h3-8,10-14,41H,9H2,1-2H3
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n/an/an/a 6.5n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoid-related orphan receptor-gamma (RORgT)


(Homo sapiens (Human))
BDBM220252
PNG
(US9290476, 97A | US9290476, 97B | US9290476, 97C)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C1CN(C1)C(C)=O)c1cnnn1C
Show InChI InChI=1S/C27H25ClF3N5O3/c1-15(37)36-13-19(14-36)26(38,23-12-32-34-35(23)2)18-8-9-22-20(11-18)24(28)21(25(33-22)39-3)10-16-4-6-17(7-5-16)27(29,30)31/h4-9,11-12,19,38H,10,13-14H2,1-3H3
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n/an/an/a 1.40n/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%