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Patent code US9296681

Compile Data Set for Download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM172726
PNG
(US9096515, 33a -(R)-Isomer | US9296681, 33a-(R)-Is...)
Show SMILES C[C@@H](CCNCCCC(N)=O)CC1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H28Cl2N2O/c1-14(7-11-23-10-2-4-18(22)24)13-19(8-3-9-19)15-5-6-16(20)17(21)12-15/h5-6,12,14,23H,2-4,7-11,13H2,1H3,(H2,22,24)/t14-/m0/s1
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0.910n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM172721
PNG
(US9096515, 21a | US9296681, 21a)
Show SMILES CCOC(=O)NCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H30Cl2N2O2/c1-4-26-19(25)24-11-10-23-18(12-14(2)3)20(8-5-9-20)15-6-7-16(21)17(22)13-15/h6-7,13-14,18,23H,4-5,8-12H2,1-3H3,(H,24,25)
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1n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM218678
PNG
(US9296681, 33a-Racemic)
Show SMILES CC(C)CC(NCCCC(N)=O)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H28Cl2N2O/c1-13(2)11-17(23-10-3-5-18(22)24)19(8-4-9-19)14-6-7-15(20)16(21)12-14/h6-7,12-13,17,23H,3-5,8-11H2,1-2H3,(H2,22,24)
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1.5n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM172722
PNG
(US9096515, 21b | US9296681, 21b)
Show SMILES CCOC(=O)NCCNC(CC(C)C)C1(CCC1)c1ccc(OCC)cc1
Show InChI InChI=1S/C22H36N2O3/c1-5-26-19-10-8-18(9-11-19)22(12-7-13-22)20(16-17(3)4)23-14-15-24-21(25)27-6-2/h8-11,17,20,23H,5-7,12-16H2,1-4H3,(H,24,25)
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2n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM172726
PNG
(US9096515, 33a -(R)-Isomer | US9296681, 33a-(R)-Is...)
Show SMILES C[C@@H](CCNCCCC(N)=O)CC1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H28Cl2N2O/c1-14(7-11-23-10-2-4-18(22)24)13-19(8-3-9-19)15-5-6-16(20)17(21)12-15/h5-6,12,14,23H,2-4,7-11,13H2,1H3,(H2,22,24)/t14-/m0/s1
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2.30n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM172729
PNG
(US9096515, 33b -(R)-Isomer | US9296681, 33b-(R)-Is...)
Show SMILES CCOc1ccc(cc1)C1(C[C@@H](C)CCNCCCC(N)=O)CCC1
Show InChI InChI=1S/C21H34N2O2/c1-3-25-19-9-7-18(8-10-19)21(12-5-13-21)16-17(2)11-15-23-14-4-6-20(22)24/h7-10,17,23H,3-6,11-16H2,1-2H3,(H2,22,24)/t17-/m0/s1
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2.79n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM172728
PNG
(US9096515, 33b -Racemic | US9296681, 33b-Racemic)
Show SMILES CCOc1ccc(cc1)C1(CC(C)CCNCCCC(N)=O)CCC1
Show InChI InChI=1S/C21H34N2O2/c1-3-25-19-9-7-18(8-10-19)21(12-5-13-21)16-17(2)11-15-23-14-4-6-20(22)24/h7-10,17,23H,3-6,11-16H2,1-2H3,(H2,22,24)
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5.49n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM172720
PNG
(US9096515, 12u | US9296681, 12u)
Show SMILES CCOc1ccc(cc1)C1(CCC1)C(CC(C)C)NCCOC(=O)CC
Show InChI InChI=1S/C22H35NO3/c1-5-21(24)26-15-14-23-20(16-17(3)4)22(12-7-13-22)18-8-10-19(11-9-18)25-6-2/h8-11,17,20,23H,5-7,12-16H2,1-4H3
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5.70n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM172719
PNG
(US9096515, 12q | US9296681, 12q)
Show SMILES CCC(=O)OCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H29Cl2NO2/c1-4-19(24)25-11-10-23-18(12-14(2)3)20(8-5-9-20)15-6-7-16(21)17(22)13-15/h6-7,13-14,18,23H,4-5,8-12H2,1-3H3
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7.20n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM218678
PNG
(US9296681, 33a-Racemic)
Show SMILES CC(C)CC(NCCCC(N)=O)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H28Cl2N2O/c1-13(2)11-17(23-10-3-5-18(22)24)19(8-4-9-19)14-6-7-15(20)16(21)12-14/h6-7,12-13,17,23H,3-5,8-11H2,1-2H3,(H2,22,24)
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8.10n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM172719
PNG
(US9096515, 12q | US9296681, 12q)
Show SMILES CCC(=O)OCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H29Cl2NO2/c1-4-19(24)25-11-10-23-18(12-14(2)3)20(8-5-9-20)15-6-7-16(21)17(22)13-15/h6-7,13-14,18,23H,4-5,8-12H2,1-3H3
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10.6n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM172721
PNG
(US9096515, 21a | US9296681, 21a)
Show SMILES CCOC(=O)NCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H30Cl2N2O2/c1-4-26-19(25)24-11-10-23-18(12-14(2)3)20(8-5-9-20)15-6-7-16(21)17(22)13-15/h6-7,13-14,18,23H,4-5,8-12H2,1-3H3,(H,24,25)
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13.4n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM172724
PNG
(US9096515, 31b | US9296681, 31b)
Show SMILES CCCC(=O)NCCNC(CC(C)C)C1(CCC1)c1ccc(OCC)cc1
Show InChI InChI=1S/C23H38N2O2/c1-5-8-22(26)25-16-15-24-21(17-18(3)4)23(13-7-14-23)19-9-11-20(12-10-19)27-6-2/h9-12,18,21,24H,5-8,13-17H2,1-4H3,(H,25,26)
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25n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM172723
PNG
(US9096515, 31a | US9296681, 31a)
Show SMILES CCCC(=O)NCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H32Cl2N2O/c1-4-6-20(26)25-12-11-24-19(13-15(2)3)21(9-5-10-21)16-7-8-17(22)18(23)14-16/h7-8,14-15,19,24H,4-6,9-13H2,1-3H3,(H,25,26)
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27.8n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM172726
PNG
(US9096515, 33a -(R)-Isomer | US9296681, 33a-(R)-Is...)
Show SMILES C[C@@H](CCNCCCC(N)=O)CC1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H28Cl2N2O/c1-14(7-11-23-10-2-4-18(22)24)13-19(8-3-9-19)15-5-6-16(20)17(21)12-15/h5-6,12,14,23H,2-4,7-11,13H2,1H3,(H2,22,24)/t14-/m0/s1
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30.3n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM172719
PNG
(US9096515, 12q | US9296681, 12q)
Show SMILES CCC(=O)OCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H29Cl2NO2/c1-4-19(24)25-11-10-23-18(12-14(2)3)20(8-5-9-20)15-6-7-16(21)17(22)13-15/h6-7,13-14,18,23H,4-5,8-12H2,1-3H3
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38.2n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM172721
PNG
(US9096515, 21a | US9296681, 21a)
Show SMILES CCOC(=O)NCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H30Cl2N2O2/c1-4-26-19(25)24-11-10-23-18(12-14(2)3)20(8-5-9-20)15-6-7-16(21)17(22)13-15/h6-7,13-14,18,23H,4-5,8-12H2,1-3H3,(H,24,25)
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38.4n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM218678
PNG
(US9296681, 33a-Racemic)
Show SMILES CC(C)CC(NCCCC(N)=O)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H28Cl2N2O/c1-13(2)11-17(23-10-3-5-18(22)24)19(8-4-9-19)14-6-7-15(20)16(21)12-14/h6-7,12-13,17,23H,3-5,8-11H2,1-2H3,(H2,22,24)
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50.1n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM172723
PNG
(US9096515, 31a | US9296681, 31a)
Show SMILES CCCC(=O)NCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H32Cl2N2O/c1-4-6-20(26)25-12-11-24-19(13-15(2)3)21(9-5-10-21)16-7-8-17(22)18(23)14-16/h7-8,14-15,19,24H,4-6,9-13H2,1-3H3,(H,25,26)
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52.7n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM172723
PNG
(US9096515, 31a | US9296681, 31a)
Show SMILES CCCC(=O)NCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H32Cl2N2O/c1-4-6-20(26)25-12-11-24-19(13-15(2)3)21(9-5-10-21)16-7-8-17(22)18(23)14-16/h7-8,14-15,19,24H,4-6,9-13H2,1-3H3,(H,25,26)
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77.7n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM172720
PNG
(US9096515, 12u | US9296681, 12u)
Show SMILES CCOc1ccc(cc1)C1(CCC1)C(CC(C)C)NCCOC(=O)CC
Show InChI InChI=1S/C22H35NO3/c1-5-21(24)26-15-14-23-20(16-17(3)4)22(12-7-13-22)18-8-10-19(11-9-18)25-6-2/h8-11,17,20,23H,5-7,12-16H2,1-4H3
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80.4n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM172727
PNG
(US9096515, 33a -(S)-Isomer | US9296681, 33a-(S)-Is...)
Show SMILES C[C@H](CCNCCCC(N)=O)CC1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H28Cl2N2O/c1-14(7-11-23-10-2-4-18(22)24)13-19(8-3-9-19)15-5-6-16(20)17(21)12-15/h5-6,12,14,23H,2-4,7-11,13H2,1H3,(H2,22,24)/t14-/m1/s1
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126n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM172729
PNG
(US9096515, 33b -(R)-Isomer | US9296681, 33b-(R)-Is...)
Show SMILES CCOc1ccc(cc1)C1(C[C@@H](C)CCNCCCC(N)=O)CCC1
Show InChI InChI=1S/C21H34N2O2/c1-3-25-19-9-7-18(8-10-19)21(12-5-13-21)16-17(2)11-15-23-14-4-6-20(22)24/h7-10,17,23H,3-6,11-16H2,1-2H3,(H2,22,24)/t17-/m0/s1
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130n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM172722
PNG
(US9096515, 21b | US9296681, 21b)
Show SMILES CCOC(=O)NCCNC(CC(C)C)C1(CCC1)c1ccc(OCC)cc1
Show InChI InChI=1S/C22H36N2O3/c1-5-26-19-10-8-18(9-11-19)22(12-7-13-22)20(16-17(3)4)23-14-15-24-21(25)27-6-2/h8-11,17,20,23H,5-7,12-16H2,1-4H3,(H,24,25)
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159n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM172724
PNG
(US9096515, 31b | US9296681, 31b)
Show SMILES CCCC(=O)NCCNC(CC(C)C)C1(CCC1)c1ccc(OCC)cc1
Show InChI InChI=1S/C23H38N2O2/c1-5-8-22(26)25-16-15-24-21(17-18(3)4)23(13-7-14-23)19-9-11-20(12-10-19)27-6-2/h9-12,18,21,24H,5-8,13-17H2,1-4H3,(H,25,26)
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251n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM172727
PNG
(US9096515, 33a -(S)-Isomer | US9296681, 33a-(S)-Is...)
Show SMILES C[C@H](CCNCCCC(N)=O)CC1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H28Cl2N2O/c1-14(7-11-23-10-2-4-18(22)24)13-19(8-3-9-19)15-5-6-16(20)17(21)12-15/h5-6,12,14,23H,2-4,7-11,13H2,1H3,(H2,22,24)/t14-/m1/s1
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300n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM172730
PNG
(US9096515, 33b -(S)-Isomer | US9296681, 33b-(S)-Is...)
Show SMILES CCOc1ccc(cc1)C1(C[C@H](C)CCNCCCC(N)=O)CCC1
Show InChI InChI=1S/C21H34N2O2/c1-3-25-19-9-7-18(8-10-19)21(12-5-13-21)16-17(2)11-15-23-14-4-6-20(22)24/h7-10,17,23H,3-6,11-16H2,1-2H3,(H2,22,24)/t17-/m1/s1
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329n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM172728
PNG
(US9096515, 33b -Racemic | US9296681, 33b-Racemic)
Show SMILES CCOc1ccc(cc1)C1(CC(C)CCNCCCC(N)=O)CCC1
Show InChI InChI=1S/C21H34N2O2/c1-3-25-19-9-7-18(8-10-19)21(12-5-13-21)16-17(2)11-15-23-14-4-6-20(22)24/h7-10,17,23H,3-6,11-16H2,1-2H3,(H2,22,24)
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472n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM172730
PNG
(US9096515, 33b -(S)-Isomer | US9296681, 33b-(S)-Is...)
Show SMILES CCOc1ccc(cc1)C1(C[C@H](C)CCNCCCC(N)=O)CCC1
Show InChI InChI=1S/C21H34N2O2/c1-3-25-19-9-7-18(8-10-19)21(12-5-13-21)16-17(2)11-15-23-14-4-6-20(22)24/h7-10,17,23H,3-6,11-16H2,1-2H3,(H2,22,24)/t17-/m1/s1
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1.09E+3n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM172722
PNG
(US9096515, 21b | US9296681, 21b)
Show SMILES CCOC(=O)NCCNC(CC(C)C)C1(CCC1)c1ccc(OCC)cc1
Show InChI InChI=1S/C22H36N2O3/c1-5-26-19-10-8-18(9-11-19)22(12-7-13-22)20(16-17(3)4)23-14-15-24-21(25)27-6-2/h8-11,17,20,23H,5-7,12-16H2,1-4H3,(H,24,25)
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1.92E+3n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM172720
PNG
(US9096515, 12u | US9296681, 12u)
Show SMILES CCOc1ccc(cc1)C1(CCC1)C(CC(C)C)NCCOC(=O)CC
Show InChI InChI=1S/C22H35NO3/c1-5-21(24)26-15-14-23-20(16-17(3)4)22(12-7-13-22)18-8-10-19(11-9-18)25-6-2/h8-11,17,20,23H,5-7,12-16H2,1-4H3
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2.34E+3n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM172727
PNG
(US9096515, 33a -(S)-Isomer | US9296681, 33a-(S)-Is...)
Show SMILES C[C@H](CCNCCCC(N)=O)CC1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H28Cl2N2O/c1-14(7-11-23-10-2-4-18(22)24)13-19(8-3-9-19)15-5-6-16(20)17(21)12-15/h5-6,12,14,23H,2-4,7-11,13H2,1H3,(H2,22,24)/t14-/m1/s1
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3.42E+3n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM172730
PNG
(US9096515, 33b -(S)-Isomer | US9296681, 33b-(S)-Is...)
Show SMILES CCOc1ccc(cc1)C1(C[C@H](C)CCNCCCC(N)=O)CCC1
Show InChI InChI=1S/C21H34N2O2/c1-3-25-19-9-7-18(8-10-19)21(12-5-13-21)16-17(2)11-15-23-14-4-6-20(22)24/h7-10,17,23H,3-6,11-16H2,1-2H3,(H2,22,24)/t17-/m1/s1
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4.03E+3n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM172724
PNG
(US9096515, 31b | US9296681, 31b)
Show SMILES CCCC(=O)NCCNC(CC(C)C)C1(CCC1)c1ccc(OCC)cc1
Show InChI InChI=1S/C23H38N2O2/c1-5-8-22(26)25-16-15-24-21(17-18(3)4)23(13-7-14-23)19-9-11-20(12-10-19)27-6-2/h9-12,18,21,24H,5-8,13-17H2,1-4H3,(H,25,26)
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4.73E+3n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM172729
PNG
(US9096515, 33b -(R)-Isomer | US9296681, 33b-(R)-Is...)
Show SMILES CCOc1ccc(cc1)C1(C[C@@H](C)CCNCCCC(N)=O)CCC1
Show InChI InChI=1S/C21H34N2O2/c1-3-25-19-9-7-18(8-10-19)21(12-5-13-21)16-17(2)11-15-23-14-4-6-20(22)24/h7-10,17,23H,3-6,11-16H2,1-2H3,(H2,22,24)/t17-/m0/s1
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6.52E+3n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM172728
PNG
(US9096515, 33b -Racemic | US9296681, 33b-Racemic)
Show SMILES CCOc1ccc(cc1)C1(CC(C)CCNCCCC(N)=O)CCC1
Show InChI InChI=1S/C21H34N2O2/c1-3-25-19-9-7-18(8-10-19)21(12-5-13-21)16-17(2)11-15-23-14-4-6-20(22)24/h7-10,17,23H,3-6,11-16H2,1-2H3,(H2,22,24)
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>1.00E+4n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%