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Patent code US9296759

Compile Data Set for Download or QSAR
Found 188 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-secretase 1


(Homo sapiens (Human))
BDBM220775
PNG
(US9296759, 48)
Show SMILES CC#CCOc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(Cl)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C24H18ClFN6O4/c1-2-3-7-34-19-12-28-16(11-29-19)22(33)30-13-4-5-17-14(9-13)24(6-8-35-23(27)32-24)15-10-18(25)31-21(26)20(15)36-17/h4-5,9-12H,6-8H2,1H3,(H2,27,32)(H,30,33)
PDB
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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 0.400n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220852
PNG
(US9296759, 115)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)-c1ccnc(F)c1
Show InChI InChI=1S/C27H20F2N6O3S/c1-37-16-3-4-19(32-13-16)25(36)33-15-2-5-21-17(11-15)27(7-9-39-26(30)35-27)18-12-20(34-24(29)23(18)38-21)14-6-8-31-22(28)10-14/h2-6,8,10-13H,7,9H2,1H3,(H2,30,35)(H,33,36)
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UniChem
US Patent
n/an/a 0.400n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220801
PNG
(US9296759, 69)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(cn3)C#N)ccc1Oc1c(F)nc(cc21)-c1cncc(F)c1
Show InChI InChI=1S/C27H17F2N7O3/c28-16-7-15(12-32-13-16)21-9-19-23(24(29)35-21)39-22-4-2-17(8-18(22)27(19)5-6-38-26(31)36-27)34-25(37)20-3-1-14(10-30)11-33-20/h1-4,7-9,11-13H,5-6H2,(H2,31,36)(H,34,37)
PDB
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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220835
PNG
(US9296759, 100)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(cn3)C#N)ccc1Oc1c(F)nc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C27H17F2N7O3/c28-22-9-15(5-7-32-22)20-11-18-23(24(29)35-20)39-21-4-2-16(10-17(21)27(18)6-8-38-26(31)36-27)34-25(37)19-3-1-14(12-30)13-33-19/h1-5,7,9-11,13H,6,8H2,(H2,31,36)(H,34,37)
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UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220822
PNG
(US9296759, 88)
Show SMILES Cc1nc(cs1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)-c1cncc(F)c1
Show InChI InChI=1S/C25H18F2N6O3S/c1-12-30-19(11-37-12)23(34)31-15-2-3-20-16(7-15)25(4-5-35-24(28)33-25)17-8-18(32-22(27)21(17)36-20)13-6-14(26)10-29-9-13/h2-3,6-11H,4-5H2,1H3,(H2,28,33)(H,31,34)
PDB
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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220803
PNG
(US9296759, 71)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3cnc(Cl)cn3)ccc1Oc1c(F)nc(cc21)-c1cncc(F)c1
Show InChI InChI=1S/C25H16ClF2N7O3/c26-20-11-31-18(10-32-20)23(36)33-14-1-2-19-15(6-14)25(3-4-37-24(29)35-25)16-7-17(34-22(28)21(16)38-19)12-5-13(27)9-30-8-12/h1-2,5-11H,3-4H2,(H2,29,35)(H,33,36)
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PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220796
PNG
(US9296759, 64)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(cn3)C#N)ccc1Oc1c(F)nc(cc21)C1=CCOCC1
Show InChI InChI=1S/C27H21FN6O4/c28-24-23-19(12-21(33-24)16-5-8-36-9-6-16)27(7-10-37-26(30)34-27)18-11-17(2-4-22(18)38-23)32-25(35)20-3-1-15(13-29)14-31-20/h1-5,11-12,14H,6-10H2,(H2,30,34)(H,32,35)
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UniChem
US Patent
n/an/a 0.740n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220834
PNG
(US9296759, 99)
Show SMILES Cc1nc(cs1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)-c1ccnc(F)c1
Show InChI InChI=1S/C25H18F2N6O3S/c1-12-30-18(11-37-12)23(34)31-14-2-3-19-15(9-14)25(5-7-35-24(28)33-25)16-10-17(32-22(27)21(16)36-19)13-4-6-29-20(26)8-13/h2-4,6,8-11H,5,7H2,1H3,(H2,28,33)(H,31,34)
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UniChem
US Patent
n/an/a 0.800n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220800
PNG
(US9296759, 68)
Show SMILES NC1=NC2(CCS1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c(F)nc(cc21)C1=CCCOC1
Show InChI InChI=1S/C26H21ClFN5O3S/c27-15-3-5-19(30-12-15)24(34)31-16-4-6-21-17(10-16)26(7-9-37-25(29)33-26)18-11-20(14-2-1-8-35-13-14)32-23(28)22(18)36-21/h2-6,10-12H,1,7-9,13H2,(H2,29,33)(H,31,34)
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PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220819
PNG
(US9296759, 85)
Show SMILES Cc1nc(cs1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C25H22FN5O4S/c1-13-28-19(12-36-13)23(32)29-15-4-5-20-16(9-15)25(6-8-34-24(27)31-25)17-10-18(14-3-2-7-33-11-14)30-22(26)21(17)35-20/h3-5,9-10,12H,2,6-8,11H2,1H3,(H2,27,31)(H,29,32)
PDB
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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220797
PNG
(US9296759, 65)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C26H23FN6O5/c1-35-21-13-29-19(12-30-21)24(34)31-15-2-3-20-16(10-15)26(6-9-37-25(28)33-26)17-11-18(14-4-7-36-8-5-14)32-23(27)22(17)38-20/h2-4,10-13H,5-9H2,1H3,(H2,28,33)(H,31,34)
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UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220818
PNG
(US9296759, 84)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C27H24FN5O5/c1-35-17-5-6-20(30-13-17)25(34)31-16-4-7-22-18(11-16)27(8-10-37-26(29)33-27)19-12-21(15-3-2-9-36-14-15)32-24(28)23(19)38-22/h3-7,11-13H,2,8-10,14H2,1H3,(H2,29,33)(H,31,34)
PDB
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PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220825
PNG
(US9296759, 91)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c(F)nc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C26H17ClF2N6O3/c27-14-1-3-18(32-12-14)24(36)33-15-2-4-20-16(10-15)26(6-8-37-25(30)35-26)17-11-19(34-23(29)22(17)38-20)13-5-7-31-21(28)9-13/h1-5,7,9-12H,6,8H2,(H2,30,35)(H,33,36)
PDB
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220854
PNG
(US9296759, 117)
Show SMILES NC1=NC2(CCS1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c(F)nc(cc21)C1=CCOCC1
Show InChI InChI=1S/C26H21ClFN5O3S/c27-15-1-3-19(30-13-15)24(34)31-16-2-4-21-17(11-16)26(7-10-37-25(29)33-26)18-12-20(14-5-8-35-9-6-14)32-23(28)22(18)36-21/h1-5,11-13H,6-10H2,(H2,29,33)(H,31,34)
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UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220844
PNG
(US9296759, 108)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(cn3)C#N)ccc1Oc1c(F)cc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C28H18F2N6O3/c29-21-10-17(16-5-7-33-24(30)11-16)9-20-25(21)39-23-4-2-18(12-19(23)28(20)6-8-38-27(32)36-28)35-26(37)22-3-1-15(13-31)14-34-22/h1-5,7,9-12,14H,6,8H2,(H2,32,36)(H,35,37)
PDB
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UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220853
PNG
(US9296759, 116)
Show SMILES NC1=NC2(CCS1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c(F)nc(cc21)C1=CCOCC1
Show InChI InChI=1S/C26H21F2N5O3S/c27-15-1-3-19(30-13-15)24(34)31-16-2-4-21-17(11-16)26(7-10-37-25(29)33-26)18-12-20(14-5-8-35-9-6-14)32-23(28)22(18)36-21/h1-5,11-13H,6-10H2,(H2,29,33)(H,31,34)
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UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220850
PNG
(US9296759, 113)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)-c1cncc(F)c1
Show InChI InChI=1S/C27H20F2N6O3S/c1-37-17-3-4-20(32-13-17)25(36)33-16-2-5-22-18(9-16)27(6-7-39-26(30)35-27)19-10-21(34-24(29)23(19)38-22)14-8-15(28)12-31-11-14/h2-5,8-13H,6-7H2,1H3,(H2,30,35)(H,33,36)
PDB
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UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220804
PNG
(US9296759, 72)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3cnc(F)cn3)ccc1Oc1c(F)nc(cc21)-c1cccnc1
Show InChI InChI=1S/C25H17F2N7O3/c26-20-12-30-18(11-31-20)23(35)32-14-3-4-19-15(8-14)25(5-7-36-24(28)34-25)16-9-17(13-2-1-6-29-10-13)33-22(27)21(16)37-19/h1-4,6,8-12H,5,7H2,(H2,28,34)(H,32,35)
PDB
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UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220833
PNG
(US9296759, 98)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)-c1ccnc(F)c1
Show InChI InChI=1S/C27H20F2N6O4/c1-37-16-3-4-19(32-13-16)25(36)33-15-2-5-21-17(11-15)27(7-9-38-26(30)35-27)18-12-20(34-24(29)23(18)39-21)14-6-8-31-22(28)10-14/h2-6,8,10-13H,7,9H2,1H3,(H2,30,35)(H,33,36)
PDB
MMDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220832
PNG
(US9296759, 97)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c(F)nc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C26H17F3N6O3/c27-14-1-3-18(32-12-14)24(36)33-15-2-4-20-16(10-15)26(6-8-37-25(30)35-26)17-11-19(34-23(29)22(17)38-20)13-5-7-31-21(28)9-13/h1-5,7,9-12H,6,8H2,(H2,30,35)(H,33,36)
PDB
MMDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220802
PNG
(US9296759, 70)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)-c1cncc(F)c1
Show InChI InChI=1S/C26H19F2N7O4/c1-37-21-12-31-19(11-32-21)24(36)33-15-2-3-20-16(7-15)26(4-5-38-25(29)35-26)17-8-18(34-23(28)22(17)39-20)13-6-14(27)10-30-9-13/h2-3,6-12H,4-5H2,1H3,(H2,29,35)(H,33,36)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220821
PNG
(US9296759, 87)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)-c1cncc(F)c1
Show InChI InChI=1S/C27H20F2N6O4/c1-37-17-3-4-20(32-13-17)25(36)33-16-2-5-22-18(9-16)27(6-7-38-26(30)35-27)19-10-21(34-24(29)23(19)39-22)14-8-15(28)12-31-11-14/h2-5,8-13H,6-7H2,1H3,(H2,30,35)(H,33,36)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220857
PNG
(US9296759, 120)
Show SMILES Cc1cc(Br)cnc1C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C27H23BrFN5O3S/c1-14-10-16(28)13-31-22(14)25(35)32-17-2-3-21-18(11-17)27(6-9-38-26(30)34-27)19-12-20(15-4-7-36-8-5-15)33-24(29)23(19)37-21/h2-4,10-13H,5-9H2,1H3,(H2,30,34)(H,32,35)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220768
PNG
(US9296759, 63)
Show SMILES NC1=N[C@@]2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c(F)nc(cc21)C1=CCOCC1
Show InChI InChI=1S/C26H21ClFN5O4/c27-15-1-3-19(30-13-15)24(34)31-16-2-4-21-17(11-16)26(7-10-36-25(29)33-26)18-12-20(14-5-8-35-9-6-14)32-23(28)22(18)37-21/h1-5,11-13H,6-10H2,(H2,29,33)(H,31,34)/t26-/m0/s1
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220836
PNG
(US9296759, 101)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C27H24FN5O4S/c1-35-17-3-4-20(30-14-17)25(34)31-16-2-5-22-18(12-16)27(8-11-38-26(29)33-27)19-13-21(15-6-9-36-10-7-15)32-24(28)23(19)37-22/h2-6,12-14H,7-11H2,1H3,(H2,29,33)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220855
PNG
(US9296759, 118)
Show SMILES NC1=NC2(CCS1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c(F)nc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C26H17F3N6O2S/c27-14-1-3-18(32-12-14)24(36)33-15-2-4-20-16(10-15)26(6-8-38-25(30)35-26)17-11-19(34-23(29)22(17)37-20)13-5-7-31-21(28)9-13/h1-5,7,9-12H,6,8H2,(H2,30,35)(H,33,36)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220812
PNG
(US9296759, 78)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3[C@]3(CCOC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C27H24FN5O5/c1-35-17-3-4-20(30-14-17)25(34)31-16-2-5-22-18(12-16)27(8-11-37-26(29)33-27)19-13-21(15-6-9-36-10-7-15)32-24(28)23(19)38-22/h2-6,12-14H,7-11H2,1H3,(H2,29,33)(H,31,34)/t27-/m0/s1
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220799
PNG
(US9296759, 67)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C26H23FN6O4S/c1-35-21-13-29-19(12-30-21)24(34)31-15-2-3-20-16(10-15)26(6-9-38-25(28)33-26)17-11-18(14-4-7-36-8-5-14)32-23(27)22(17)37-20/h2-4,10-13H,5-9H2,1H3,(H2,28,33)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220823
PNG
(US9296759, 89)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c(F)nc(cc21)-c1cncc(F)c1
Show InChI InChI=1S/C26H17F3N6O3/c27-14-1-3-19(32-12-14)24(36)33-16-2-4-21-17(8-16)26(5-6-37-25(30)35-26)18-9-20(34-23(29)22(18)38-21)13-7-15(28)11-31-10-13/h1-4,7-12H,5-6H2,(H2,30,35)(H,33,36)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220828
PNG
(US9296759, 94)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1cnc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C26H18ClFN6O3/c27-15-1-3-19(31-12-15)24(35)33-16-2-4-21-17(10-16)26(6-8-36-25(29)34-26)18-11-20(32-13-22(18)37-21)14-5-7-30-23(28)9-14/h1-5,7,9-13H,6,8H2,(H2,29,34)(H,33,35)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220839
PNG
(US9296759, 103)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3cnc(cc3C3(CCSC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C26H24N6O4S/c1-34-23-14-29-20(12-30-23)24(33)31-16-2-3-21-17(10-16)26(6-9-37-25(27)32-26)18-11-19(28-13-22(18)36-21)15-4-7-35-8-5-15/h2-4,10-14H,5-9H2,1H3,(H2,27,32)(H,31,33)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220798
PNG
(US9296759, 66)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C26H23FN6O4S/c1-35-21-12-29-19(11-30-21)24(34)31-15-4-5-20-16(9-15)26(6-8-38-25(28)33-26)17-10-18(14-3-2-7-36-13-14)32-23(27)22(17)37-20/h3-5,9-12H,2,6-8,13H2,1H3,(H2,28,33)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220826
PNG
(US9296759, 92)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)-c1ccnc(F)c1
Show InChI InChI=1S/C26H19F2N7O4/c1-37-21-12-31-18(11-32-21)24(36)33-14-2-3-19-15(9-14)26(5-7-38-25(29)35-26)16-10-17(34-23(28)22(16)39-19)13-4-6-30-20(27)8-13/h2-4,6,8-12H,5,7H2,1H3,(H2,29,35)(H,33,36)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220783
PNG
(US9296759, 39)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c(F)nc(cc21)C1=CCCOC1
Show InChI InChI=1S/C26H21ClFN5O4/c27-15-3-5-19(30-12-15)24(34)31-16-4-6-21-17(10-16)26(7-9-36-25(29)33-26)18-11-20(14-2-1-8-35-13-14)32-23(28)22(18)37-21/h2-6,10-12H,1,7-9,13H2,(H2,29,33)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220785
PNG
(US9296759, 52)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(cn3)C#N)ccc1Oc1c(F)nc(cc21)C1=CCCOC1
Show InChI InChI=1S/C27H21FN6O4/c28-24-23-19(11-21(33-24)16-2-1-8-36-14-16)27(7-9-37-26(30)34-27)18-10-17(4-6-22(18)38-23)32-25(35)20-5-3-15(12-29)13-31-20/h2-6,10-11,13H,1,7-9,14H2,(H2,30,34)(H,32,35)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220787
PNG
(US9296759, 40)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c(F)nc(cc21)C1CC1
Show InChI InChI=1S/C24H19ClFN5O3/c25-13-3-5-17(28-11-13)22(32)29-14-4-6-19-15(9-14)24(7-8-33-23(27)31-24)16-10-18(12-1-2-12)30-21(26)20(16)34-19/h3-6,9-12H,1-2,7-8H2,(H2,27,31)(H,29,32)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220848
PNG
(US9296759, 111)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C27H24FN5O4S/c1-35-17-5-6-20(30-13-17)25(34)31-16-4-7-22-18(11-16)27(8-10-38-26(29)33-27)19-12-21(15-3-2-9-36-14-15)32-24(28)23(19)37-22/h3-7,11-13H,2,8-10,14H2,1H3,(H2,29,33)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220856
PNG
(US9296759, 119)
Show SMILES NC1=NC2(CCS1)c1cc(NC(=O)c3ncc(Cl)cc3F)ccc1Oc1c(F)nc(cc21)C1=CCOCC1
Show InChI InChI=1S/C26H20ClF2N5O3S/c27-14-9-18(28)21(31-12-14)24(35)32-15-1-2-20-16(10-15)26(5-8-38-25(30)34-26)17-11-19(13-3-6-36-7-4-13)33-23(29)22(17)37-20/h1-3,9-12H,4-8H2,(H2,30,34)(H,32,35)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220779
PNG
(US9296759, 45)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1ncc(cc21)C1=CCOCC1
Show InChI InChI=1S/C26H22ClN5O4/c27-17-1-3-21(29-14-17)23(33)31-18-2-4-22-19(12-18)26(7-10-35-25(28)32-26)20-11-16(13-30-24(20)36-22)15-5-8-34-9-6-15/h1-5,11-14H,6-10H2,(H2,28,32)(H,31,33)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220784
PNG
(US9296759, 51)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C26H23FN6O5/c1-35-21-12-29-19(11-30-21)24(34)31-15-4-5-20-16(9-15)26(6-8-37-25(28)33-26)17-10-18(14-3-2-7-36-13-14)32-23(27)22(17)38-20/h3-5,9-12H,2,6-8,13H2,1H3,(H2,28,33)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220849
PNG
(US9296759, 112)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)-c1cncc(F)c1
Show InChI InChI=1S/C26H19F2N7O3S/c1-37-21-12-31-19(11-32-21)24(36)33-15-2-3-20-16(7-15)26(4-5-39-25(29)35-26)17-8-18(34-23(28)22(17)38-20)13-6-14(27)10-30-9-13/h2-3,6-12H,4-5H2,1H3,(H2,29,35)(H,33,36)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220827
PNG
(US9296759, 93)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3cnc(cc3C3(CCOC(N)=N3)c2c1)-c1ccnc(F)c1
Show InChI InChI=1S/C26H20FN7O4/c1-36-23-13-31-19(11-32-23)24(35)33-15-2-3-20-16(9-15)26(5-7-37-25(28)34-26)17-10-18(30-12-21(17)38-20)14-4-6-29-22(27)8-14/h2-4,6,8-13H,5,7H2,1H3,(H2,28,34)(H,33,35)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220859
PNG
(US9296759, 122)
Show SMILES Cc1cc(Cl)cnc1C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C27H23ClFN5O3S/c1-14-10-16(28)13-31-22(14)25(35)32-17-2-3-21-18(11-17)27(6-9-38-26(30)34-27)19-12-20(15-4-7-36-8-5-15)33-24(29)23(19)37-21/h2-4,10-13H,5-9H2,1H3,(H2,30,34)(H,32,35)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220767
PNG
(US9296759, 59)
Show SMILES Cc1ccc(nc1)C(=O)Nc1ccc2Oc3cnc(cc3[C@]3(CCOC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C27H25N5O4/c1-16-4-6-21(29-13-16)25(33)31-18-5-7-23-19(11-18)27(8-10-35-26(28)32-27)20-12-22(30-14-24(20)36-23)17-3-2-9-34-15-17/h3-7,11-14H,2,8-10,15H2,1H3,(H2,28,32)(H,31,33)/t27-/m0/s1
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220806
PNG
(US9296759, 59)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1cnc(cc21)C1=CCCOC1
Show InChI InChI=1S/C26H22ClN5O4/c27-16-3-5-20(29-12-16)24(33)31-17-4-6-22-18(10-17)26(7-9-35-25(28)32-26)19-11-21(30-13-23(19)36-22)15-2-1-8-34-14-15/h2-6,10-13H,1,7-9,14H2,(H2,28,32)(H,31,33)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220851
PNG
(US9296759, 114)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)-c1ccnc(F)c1
Show InChI InChI=1S/C26H19F2N7O3S/c1-37-21-12-31-18(11-32-21)24(36)33-14-2-3-19-15(9-14)26(5-7-39-25(29)35-26)16-10-17(34-23(28)22(16)38-19)13-4-6-30-20(27)8-13/h2-4,6,8-12H,5,7H2,1H3,(H2,29,35)(H,33,36)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220840
PNG
(US9296759, 104)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3cnc(cc3C3(CCSC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C26H24N6O4S/c1-34-23-13-29-20(11-30-23)24(33)31-16-4-5-21-17(9-16)26(6-8-37-25(27)32-26)18-10-19(28-12-22(18)36-21)15-3-2-7-35-14-15/h3-5,9-13H,2,6-8,14H2,1H3,(H2,27,32)(H,31,33)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220824
PNG
(US9296759, 90)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1ncc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C26H18ClFN6O3/c27-16-1-3-20(31-13-16)23(35)33-17-2-4-21-18(11-17)26(6-8-36-25(29)34-26)19-9-15(12-32-24(19)37-21)14-5-7-30-22(28)10-14/h1-5,7,9-13H,6,8H2,(H2,29,34)(H,33,35)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220788
PNG
(US9296759, 54)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)C1CC1
Show InChI InChI=1S/C24H21FN6O4/c1-33-19-11-27-17(10-28-19)22(32)29-13-4-5-18-14(8-13)24(6-7-34-23(26)31-24)15-9-16(12-2-3-12)30-21(25)20(15)35-18/h4-5,8-12H,2-3,6-7H2,1H3,(H2,26,31)(H,29,32)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220789
PNG
(US9296759, 35)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1ncc(cc21)C1=CCCOC1
Show InChI InChI=1S/C26H22ClN5O4/c27-17-3-5-21(29-13-17)23(33)31-18-4-6-22-19(11-18)26(7-9-35-25(28)32-26)20-10-16(12-30-24(20)36-22)15-2-1-8-34-14-15/h2-6,10-13H,1,7-9,14H2,(H2,28,32)(H,31,33)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220858
PNG
(US9296759, 121)
Show SMILES COc1cnc(C(=O)Nc2ccc3Oc4c(F)nc(cc4C4(CCSC(N)=N4)c3c2)C2=CCOCC2)c(C)c1
Show InChI InChI=1S/C28H26FN5O4S/c1-15-11-18(36-2)14-31-23(15)26(35)32-17-3-4-22-19(12-17)28(7-10-39-27(30)34-28)20-13-21(16-5-8-37-9-6-16)33-25(29)24(20)38-22/h3-5,11-14H,6-10H2,1-2H3,(H2,30,34)(H,32,35)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220790
PNG
(US9296759, 55 | US9296759, 56)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(Cl)cc3C3(CCSC(N)=N3)c2c1
Show InChI InChI=1S/C21H16ClFN6O3S/c1-31-16-9-25-13(8-26-16)19(30)27-10-2-3-14-11(6-10)21(4-5-33-20(24)29-21)12-7-15(22)28-18(23)17(12)32-14/h2-3,6-9H,4-5H2,1H3,(H2,24,29)(H,27,30)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220847
PNG
(US9296759, 60)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)cc(cc3C3(CCSC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C27H24FN5O4S/c1-35-23-14-30-21(13-31-23)25(34)32-17-2-3-22-18(12-17)27(6-9-38-26(29)33-27)19-10-16(11-20(28)24(19)37-22)15-4-7-36-8-5-15/h2-4,10-14H,5-9H2,1H3,(H2,29,33)(H,32,34)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220829
PNG
(US9296759, 95)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)cc(cc3C3(CCOC(N)=N3)c2c1)-c1ccnc(F)c1
Show InChI InChI=1S/C27H20F2N6O4/c1-37-23-13-32-20(12-33-23)25(36)34-16-2-3-21-17(11-16)27(5-7-38-26(30)35-27)18-8-15(9-19(28)24(18)39-21)14-4-6-31-22(29)10-14/h2-4,6,8-13H,5,7H2,1H3,(H2,30,35)(H,34,36)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220814
PNG
(US9296759, 80)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3cnc(cc3C3(CCOC(N)=N3)c2c1)C1CC1
Show InChI InChI=1S/C24H22N6O4/c1-32-21-12-27-18(10-28-21)22(31)29-14-4-5-19-15(8-14)24(6-7-33-23(25)30-24)16-9-17(13-2-3-13)26-11-20(16)34-19/h4-5,8-13H,2-3,6-7H2,1H3,(H2,25,30)(H,29,31)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220842
PNG
(US9296759, 106)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)cc(cc3C3(CCOC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C27H24FN5O5/c1-35-23-13-30-21(12-31-23)25(34)32-17-4-5-22-18(11-17)27(6-8-37-26(29)33-27)19-9-16(10-20(28)24(19)38-22)15-3-2-7-36-14-15/h3-5,9-13H,2,6-8,14H2,1H3,(H2,29,33)(H,32,34)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220772
PNG
(US9296759, 38)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c(F)nc(Cl)cc21
Show InChI InChI=1S/C21H14Cl2FN5O3/c22-10-1-3-14(26-9-10)19(30)27-11-2-4-15-12(7-11)21(5-6-31-20(25)29-21)13-8-16(23)28-18(24)17(13)32-15/h1-4,7-9H,5-6H2,(H2,25,29)(H,27,30)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220830
PNG
(US9296759, 62)
Show SMILES COc1nc(cc2c1Oc1ccc(NC(=O)c3ccc(Cl)cn3)cc1C21CCOC(N)=N1)C1=CCOCC1
Show InChI InChI=1S/C27H24ClN5O5/c1-35-25-23-19(13-21(32-25)15-6-9-36-10-7-15)27(8-11-37-26(29)33-27)18-12-17(3-5-22(18)38-23)31-24(34)20-4-2-16(28)14-30-20/h2-6,12-14H,7-11H2,1H3,(H2,29,33)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220773
PNG
(US9296759, 46)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(cn3)C#N)ccc1Oc1c(F)nc(Cl)cc21
Show InChI InChI=1S/C22H14ClFN6O3/c23-17-8-14-18(19(24)29-17)33-16-4-2-12(7-13(16)22(14)5-6-32-21(26)30-22)28-20(31)15-3-1-11(9-25)10-27-15/h1-4,7-8,10H,5-6H2,(H2,26,30)(H,28,31)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220843
PNG
(US9296759, 107)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)cc(cc3C3(CCSC(N)=N3)c2c1)N1CCOCC1
Show InChI InChI=1S/C27H26FN5O4S/c1-35-18-3-4-22(30-15-18)25(34)31-16-2-5-23-19(12-16)27(6-11-38-26(29)32-27)20-13-17(14-21(28)24(20)37-23)33-7-9-36-10-8-33/h2-5,12-15H,6-11H2,1H3,(H2,29,32)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220838
PNG
(US9296759, 102)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c(F)cc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C27H18F3N5O3/c28-16-1-3-21(33-13-16)25(36)34-17-2-4-22-18(12-17)27(6-8-37-26(31)35-27)19-9-15(10-20(29)24(19)38-22)14-5-7-32-23(30)11-14/h1-5,7,9-13H,6,8H2,(H2,31,35)(H,34,36)
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n/an/a 8.80n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220817
PNG
(US9296759, 83)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c(F)nc(cc21)C1=CCCOC1
Show InChI InChI=1S/C26H21F2N5O4/c27-15-3-5-19(30-12-15)24(34)31-16-4-6-21-17(10-16)26(7-9-36-25(29)33-26)18-11-20(14-2-1-8-35-13-14)32-23(28)22(18)37-21/h2-6,10-12H,1,7-9,13H2,(H2,29,33)(H,31,34)
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n/an/a 9.30n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220766
PNG
(US9296759, 58)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3cnc(cc3[C@]3(CCOC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C26H24N6O5/c1-34-23-13-29-20(11-30-23)24(33)31-16-4-5-21-17(9-16)26(6-8-36-25(27)32-26)18-10-19(28-12-22(18)37-21)15-3-2-7-35-14-15/h3-5,9-13H,2,6-8,14H2,1H3,(H2,27,32)(H,31,33)/t26-/m0/s1
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n/an/a 9.40n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220805
PNG
(US9296759, 58)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3cnc(cc3C3(CCOC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C26H24N6O5/c1-34-23-13-29-20(11-30-23)24(33)31-16-4-5-21-17(9-16)26(6-8-36-25(27)32-26)18-10-19(28-12-22(18)37-21)15-3-2-7-35-14-15/h3-5,9-13H,2,6-8,14H2,1H3,(H2,27,32)(H,31,33)
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n/an/a 9.40n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220816
PNG
(US9296759, 82)
Show SMILES CC(C)(C)C#Cc1cc2c(Oc3ccc(NC(=O)c4ccc(Cl)cn4)cc3C22CCOC(N)=N2)cn1
Show InChI InChI=1S/C27H24ClN5O3/c1-26(2,3)9-8-17-12-20-23(15-30-17)36-22-7-5-18(32-24(34)21-6-4-16(28)14-31-21)13-19(22)27(20)10-11-35-25(29)33-27/h4-7,12-15H,10-11H2,1-3H3,(H2,29,33)(H,32,34)
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220815
PNG
(US9296759, 81)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1cnc(cc21)C1CC1
Show InChI InChI=1S/C24H20ClN5O3/c25-14-3-5-18(27-11-14)22(31)29-15-4-6-20-16(9-15)24(7-8-32-23(26)30-24)17-10-19(13-1-2-13)28-12-21(17)33-20/h3-6,9-13H,1-2,7-8H2,(H2,26,30)(H,29,31)
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n/an/a 10.7n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220808
PNG
(US9296759, 74)
Show SMILES COc1cc(F)c2Oc3ccc(NC(=O)c4ccc(cn4)C#N)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C24H18FN5O4/c1-32-15-9-17-21(18(25)10-15)34-20-5-3-14(8-16(20)24(17)6-7-33-23(27)30-24)29-22(31)19-4-2-13(11-26)12-28-19/h2-5,8-10,12H,6-7H2,1H3,(H2,27,30)(H,29,31)
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n/an/a 10.8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220820
PNG
(US9296759, 86)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3cnc(cc3C3(CCOC(N)=N3)c2c1)C#CC(C)(C)C
Show InChI InChI=1S/C27H26N6O4/c1-26(2,3)8-7-16-11-19-22(14-29-16)37-21-6-5-17(12-18(21)27(19)9-10-36-25(28)33-27)32-24(34)20-13-31-23(35-4)15-30-20/h5-6,11-15H,9-10H2,1-4H3,(H2,28,33)(H,32,34)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220807
PNG
(US9296759, 73)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1ncc(cc21)C1CC1
Show InChI InChI=1S/C24H20ClN5O3/c25-15-3-5-19(27-12-15)21(31)29-16-4-6-20-17(10-16)24(7-8-32-23(26)30-24)18-9-14(13-1-2-13)11-28-22(18)33-20/h3-6,9-13H,1-2,7-8H2,(H2,26,30)(H,29,31)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220786
PNG
(US9296759, 53)
Show SMILES COc1nc(cc2c1Oc1ccc(NC(=O)c3ccc(Cl)cn3)cc1C21CCOC(N)=N1)C1CC1
Show InChI InChI=1S/C25H22ClN5O4/c1-33-23-21-17(11-19(30-23)13-2-3-13)25(8-9-34-24(27)31-25)16-10-15(5-7-20(16)35-21)29-22(32)18-6-4-14(26)12-28-18/h4-7,10-13H,2-3,8-9H2,1H3,(H2,27,31)(H,29,32)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220769
PNG
(US9296759, 34)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1ncc(Br)cc21
Show InChI InChI=1S/C21H15BrClN5O3/c22-11-7-15-19(26-9-11)31-17-4-2-13(27-18(29)16-3-1-12(23)10-25-16)8-14(17)21(15)5-6-30-20(24)28-21/h1-4,7-10H,5-6H2,(H2,24,28)(H,27,29)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220846
PNG
(US9296759, 110)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)cc(cc3C3(CCSC(N)=N3)c2c1)N1CCOCC1
Show InChI InChI=1S/C26H25FN6O4S/c1-35-22-14-29-20(13-30-22)24(34)31-15-2-3-21-17(10-15)26(4-9-38-25(28)32-26)18-11-16(12-19(27)23(18)37-21)33-5-7-36-8-6-33/h2-3,10-14H,4-9H2,1H3,(H2,28,32)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220776
PNG
(US9296759, 49)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3cnc(Cl)cn3)ccc1Oc1c(F)nc(Cl)cc21
Show InChI InChI=1S/C20H13Cl2FN6O3/c21-14-6-11-16(17(23)28-14)32-13-2-1-9(27-18(30)12-7-26-15(22)8-25-12)5-10(13)20(11)3-4-31-19(24)29-20/h1-2,5-8H,3-4H2,(H2,24,29)(H,27,30)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220777
PNG
(US9296759, 32)
Show SMILES COc1cc(F)c2Oc3ccc(NC(=O)c4ccc(Cl)cn4)cc3C3(CCSC(N)=N3)c2c1
Show InChI InChI=1S/C23H18ClFN4O3S/c1-31-14-9-16-20(17(25)10-14)32-19-5-3-13(28-21(30)18-4-2-12(24)11-27-18)8-15(19)23(16)6-7-33-22(26)29-23/h2-5,8-11H,6-7H2,1H3,(H2,26,29)(H,28,30)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220831
PNG
(US9296759, 96)
Show SMILES COc1nc(cc2c1Oc1ccc(NC(=O)c3ccc(F)cn3)cc1C21CCOC(N)=N1)C1=CCOCC1
Show InChI InChI=1S/C27H24FN5O5/c1-35-25-23-19(13-21(32-25)15-6-9-36-10-7-15)27(8-11-37-26(29)33-27)18-12-17(3-5-22(18)38-23)31-24(34)20-4-2-16(28)14-30-20/h2-6,12-14H,7-11H2,1H3,(H2,29,33)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220774
PNG
(US9296759, 47)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(Cl)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C21H16ClFN6O4/c1-31-16-9-25-13(8-26-16)19(30)27-10-2-3-14-11(6-10)21(4-5-32-20(24)29-21)12-7-15(22)28-18(23)17(12)33-14/h2-3,6-9H,4-5H2,1H3,(H2,24,29)(H,27,30)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220845
PNG
(US9296759, 109)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)cc(O)cc3C3(CCSC(N)=N3)c2c1
Show InChI InChI=1S/C22H18FN5O4S/c1-31-18-10-25-16(9-26-18)20(30)27-11-2-3-17-13(6-11)22(4-5-33-21(24)28-22)14-7-12(29)8-15(23)19(14)32-17/h2-3,6-10,29H,4-5H2,1H3,(H2,24,28)(H,27,30)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220841
PNG
(US9296759, 105)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)cc(O)cc3C3(CCSC(N)=N3)c2c1
Show InChI InChI=1S/C23H19FN4O4S/c1-31-14-3-4-18(26-11-14)21(30)27-12-2-5-19-15(8-12)23(6-7-33-22(25)28-23)16-9-13(29)10-17(24)20(16)32-19/h2-5,8-11,29H,6-7H2,1H3,(H2,25,28)(H,27,30)
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n/an/a 29.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220837
PNG
(US9296759, 61)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)cc(cc3C3(CCOC(N)=N3)c2c1)C1CCOCC1
Show InChI InChI=1S/C27H26FN5O5/c1-35-23-14-30-21(13-31-23)25(34)32-17-2-3-22-18(12-17)27(6-9-37-26(29)33-27)19-10-16(11-20(28)24(19)38-22)15-4-7-36-8-5-15/h2-3,10-15H,4-9H2,1H3,(H2,29,33)(H,32,34)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220780
PNG
(US9296759, 42)
Show SMILES COc1cc(F)c2Oc3ccc(NC(=O)c4ccc(Cl)cn4)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C23H18ClFN4O4/c1-31-14-9-16-20(17(25)10-14)33-19-5-3-13(28-21(30)18-4-2-12(24)11-27-18)8-15(19)23(16)6-7-32-22(26)29-23/h2-5,8-11H,6-7H2,1H3,(H2,26,29)(H,28,30)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220813
PNG
(US9296759, 79)
Show SMILES NC1=NC2(CCO1)c1cc(Cl)ncc1Oc1ccc(NC(=O)c3ccc(Cl)cn3)cc21
Show InChI InChI=1S/C21H15Cl2N5O3/c22-11-1-3-15(25-9-11)19(29)27-12-2-4-16-13(7-12)21(5-6-30-20(24)28-21)14-8-18(23)26-10-17(14)31-16/h1-4,7-10H,5-6H2,(H2,24,28)(H,27,29)
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Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220778
PNG
(US9296759, 50)
Show SMILES COc1cc(F)c2Oc3ccc(NC(=O)c4cnc(OC)cn4)cc3C3(CCSC(N)=N3)c2c1
Show InChI InChI=1S/C23H20FN5O4S/c1-31-13-8-15-20(16(24)9-13)33-18-4-3-12(7-14(18)23(15)5-6-34-22(25)29-23)28-21(30)17-10-27-19(32-2)11-26-17/h3-4,7-11H,5-6H2,1-2H3,(H2,25,29)(H,28,30)
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n/an/a 40.5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220781
PNG
(US9296759, 36)
Show SMILES NC1=NC2(CCO1)c1cccnc1Oc1ccc(NC(=O)c3ccc(Cl)cn3)cc21
Show InChI InChI=1S/C21H16ClN5O3/c22-12-3-5-16(25-11-12)18(28)26-13-4-6-17-15(10-13)21(7-9-29-20(23)27-21)14-2-1-8-24-19(14)30-17/h1-6,8,10-11H,7,9H2,(H2,23,27)(H,26,28)
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n/an/a 45.1n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220771
PNG
(US9296759, 44)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3ncc(Br)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C21H17BrN6O4/c1-30-17-10-24-15(9-25-17)18(29)27-12-2-3-16-13(7-12)21(4-5-31-20(23)28-21)14-6-11(22)8-26-19(14)32-16/h2-3,6-10H,4-5H2,1H3,(H2,23,28)(H,27,29)
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n/an/a 47.6n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220793
PNG
(US9296759, 33)
Show SMILES CCOc1cccnc1Nc1ccc2Oc3c(F)cc(OC)cc3C3(CCSC(N)=N3)c2c1
Show InChI InChI=1S/C24H23FN4O3S/c1-3-31-20-5-4-9-27-22(20)28-14-6-7-19-16(11-14)24(8-10-33-23(26)29-24)17-12-15(30-2)13-18(25)21(17)32-19/h4-7,9,11-13H,3,8,10H2,1-2H3,(H2,26,29)(H,27,28)
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n/an/a 48.6n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220795
PNG
(US9296759, 31)
Show SMILES CCOc1cccnc1Nc1ccc2Oc3c(F)cc(OC)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C24H23FN4O4/c1-3-31-20-5-4-9-27-22(20)28-14-6-7-19-16(11-14)24(8-10-32-23(26)29-24)17-12-15(30-2)13-18(25)21(17)33-19/h4-7,9,11-13H,3,8,10H2,1-2H3,(H2,26,29)(H,27,28)
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n/an/a 69.6n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220809
PNG
(US9296759, 75)
Show SMILES COc1cc(F)c2Oc3ccc(NC(=O)c4cnc(OC)cn4)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C23H20FN5O5/c1-31-13-8-15-20(16(24)9-13)34-18-4-3-12(7-14(18)23(15)5-6-33-22(25)29-23)28-21(30)17-10-27-19(32-2)11-26-17/h3-4,7-11H,5-6H2,1-2H3,(H2,25,29)(H,28,30)
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n/an/a 95.3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220770
PNG
(US9296759, 43)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3cnc(O)cn3)ccc1Oc1ncc(Br)cc21
Show InChI InChI=1S/C20H15BrN6O4/c21-10-5-13-18(25-7-10)31-15-2-1-11(26-17(29)14-8-24-16(28)9-23-14)6-12(15)20(13)3-4-30-19(22)27-20/h1-2,5-9H,3-4H2,(H2,22,27)(H,24,28)(H,26,29)
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n/an/a 113n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220782
PNG
(US9296759, 37)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cc3F)ccc1Oc1ncc(Br)cc21
Show InChI InChI=1S/C22H15BrClFN4O3/c23-11-7-16-20(27-10-11)32-18-4-2-13(9-15(18)22(16)5-6-31-21(26)29-22)28-19(30)14-3-1-12(24)8-17(14)25/h1-4,7-10H,5-6H2,(H2,26,29)(H,28,30)
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n/an/a 120n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220810
PNG
(US9296759, 76)
Show SMILES COc1cc(F)c2Oc3ccc(NC(=O)c4ccc(Cl)cc4F)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C24H18ClF2N3O4/c1-32-14-10-17-21(19(27)11-14)34-20-5-3-13(9-16(20)24(17)6-7-33-23(28)30-24)29-22(31)15-4-2-12(25)8-18(15)26/h2-5,8-11H,6-7H2,1H3,(H2,28,30)(H,29,31)
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n/an/a 182n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220792
PNG
(US9296759, 41)
Show SMILES Cc1cccnc1Nc1ccc2Oc3c(F)nc(Cl)cc3[C@]3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C21H17ClFN5O2/c1-11-3-2-7-25-19(11)26-12-4-5-15-13(9-12)21(6-8-29-20(24)28-21)14-10-16(22)27-18(23)17(14)30-15/h2-5,7,9-10H,6,8H2,1H3,(H2,24,28)(H,25,26)/t21-/m0/s1
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n/an/a 254n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220811
PNG
(US9296759, 77)
Show SMILES COc1ccc(C(=O)Nc2ccc3Oc4c(F)cc(OC)cc4C4(CCOC(N)=N4)c3c2)c(F)c1
Show InChI InChI=1S/C25H21F2N3O5/c1-32-14-4-5-16(19(26)11-14)23(31)29-13-3-6-21-17(9-13)25(7-8-34-24(28)30-25)18-10-15(33-2)12-20(27)22(18)35-21/h3-6,9-12H,7-8H2,1-2H3,(H2,28,30)(H,29,31)
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n/an/a 315n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220790
PNG
(US9296759, 55 | US9296759, 56)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(Cl)cc3C3(CCSC(N)=N3)c2c1
Show InChI InChI=1S/C21H16ClFN6O3S/c1-31-16-9-25-13(8-26-16)19(30)27-10-2-3-14-11(6-10)21(4-5-33-20(24)29-21)12-7-15(22)28-18(23)17(12)32-14/h2-3,6-9H,4-5H2,1H3,(H2,24,29)(H,27,30)
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n/an/a 914n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220789
PNG
(US9296759, 35)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1ncc(cc21)C1=CCCOC1
Show InChI InChI=1S/C26H22ClN5O4/c27-17-3-5-21(29-13-17)23(33)31-18-4-6-22-19(11-18)26(7-9-35-25(28)32-26)20-10-16(12-30-24(20)36-22)15-2-1-8-34-14-15/h2-6,10-13H,1,7-9,14H2,(H2,28,32)(H,31,33)
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n/an/a>1.65E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220771
PNG
(US9296759, 44)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3ncc(Br)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C21H17BrN6O4/c1-30-17-10-24-15(9-25-17)18(29)27-12-2-3-16-13(7-12)21(4-5-31-20(23)28-21)14-6-11(22)8-26-19(14)32-16/h2-3,6-10H,4-5H2,1H3,(H2,23,28)(H,27,29)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220770
PNG
(US9296759, 43)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3cnc(O)cn3)ccc1Oc1ncc(Br)cc21
Show InChI InChI=1S/C20H15BrN6O4/c21-10-5-13-18(25-7-10)31-15-2-1-11(26-17(29)14-8-24-16(28)9-23-14)6-12(15)20(13)3-4-30-19(22)27-20/h1-2,5-9H,3-4H2,(H2,22,27)(H,24,28)(H,26,29)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM220794
PNG
(US9296759, 57)
Show SMILES COc1cc(F)c2Oc3ccc(Nc4ncccc4OCc4ccccc4)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C29H25FN4O4/c1-35-20-15-22-26(23(30)16-20)38-24-10-9-19(14-21(24)29(22)11-13-36-28(31)34-29)33-27-25(8-5-12-32-27)37-17-18-6-3-2-4-7-18/h2-10,12,14-16H,11,13,17H2,1H3,(H2,31,34)(H,32,33)
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n/an/a 7.29E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220790
PNG
(US9296759, 55 | US9296759, 56)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(Cl)cc3C3(CCSC(N)=N3)c2c1
Show InChI InChI=1S/C21H16ClFN6O3S/c1-31-16-9-25-13(8-26-16)19(30)27-10-2-3-14-11(6-10)21(4-5-33-20(24)29-21)12-7-15(22)28-18(23)17(12)32-14/h2-3,6-9H,4-5H2,1H3,(H2,24,29)(H,27,30)
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n/an/a 6.99E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220857
PNG
(US9296759, 120)
Show SMILES Cc1cc(Br)cnc1C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C27H23BrFN5O3S/c1-14-10-16(28)13-31-22(14)25(35)32-17-2-3-21-18(11-17)27(6-9-38-26(30)34-27)19-12-20(15-4-7-36-8-5-15)33-24(29)23(19)37-21/h2-4,10-13H,5-9H2,1H3,(H2,30,34)(H,32,35)
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n/an/a 8.83E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220842
PNG
(US9296759, 106)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)cc(cc3C3(CCOC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C27H24FN5O5/c1-35-23-13-30-21(12-31-23)25(34)32-17-4-5-22-18(11-17)27(6-8-37-26(29)33-27)19-9-16(10-20(28)24(19)38-22)15-3-2-7-36-14-15/h3-5,9-13H,2,6-8,14H2,1H3,(H2,29,33)(H,32,34)
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n/an/a 1.07E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220850
PNG
(US9296759, 113)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)-c1cncc(F)c1
Show InChI InChI=1S/C27H20F2N6O3S/c1-37-17-3-4-20(32-13-17)25(36)33-16-2-5-22-18(9-16)27(6-7-39-26(30)35-27)19-10-21(34-24(29)23(19)38-22)14-8-15(28)12-31-11-14/h2-5,8-13H,6-7H2,1H3,(H2,30,35)(H,33,36)
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n/an/a 1.20E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220785
PNG
(US9296759, 52)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(cn3)C#N)ccc1Oc1c(F)nc(cc21)C1=CCCOC1
Show InChI InChI=1S/C27H21FN6O4/c28-24-23-19(11-21(33-24)16-2-1-8-36-14-16)27(7-9-37-26(30)34-27)18-10-17(4-6-22(18)38-23)32-25(35)20-5-3-15(12-29)13-31-20/h2-6,10-11,13H,1,7-9,14H2,(H2,30,34)(H,32,35)
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n/an/a 1.32E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220854
PNG
(US9296759, 117)
Show SMILES NC1=NC2(CCS1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c(F)nc(cc21)C1=CCOCC1
Show InChI InChI=1S/C26H21ClFN5O3S/c27-15-1-3-19(30-13-15)24(34)31-16-2-4-21-17(11-16)26(7-10-37-25(29)33-26)18-12-20(14-5-8-35-9-6-14)32-23(28)22(18)36-21/h1-5,11-13H,6-10H2,(H2,29,33)(H,31,34)
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n/an/a 1.33E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220801
PNG
(US9296759, 69)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(cn3)C#N)ccc1Oc1c(F)nc(cc21)-c1cncc(F)c1
Show InChI InChI=1S/C27H17F2N7O3/c28-16-7-15(12-32-13-16)21-9-19-23(24(29)35-21)39-22-4-2-17(8-18(22)27(19)5-6-38-26(31)36-27)34-25(37)20-3-1-14(10-30)11-33-20/h1-4,7-9,11-13H,5-6H2,(H2,31,36)(H,34,37)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220859
PNG
(US9296759, 122)
Show SMILES Cc1cc(Cl)cnc1C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C27H23ClFN5O3S/c1-14-10-16(28)13-31-22(14)25(35)32-17-2-3-21-18(11-17)27(6-9-38-26(30)34-27)19-12-20(15-4-7-36-8-5-15)33-24(29)23(19)37-21/h2-4,10-13H,5-9H2,1H3,(H2,30,34)(H,32,35)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220808
PNG
(US9296759, 74)
Show SMILES COc1cc(F)c2Oc3ccc(NC(=O)c4ccc(cn4)C#N)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C24H18FN5O4/c1-32-15-9-17-21(18(25)10-15)34-20-5-3-14(8-16(20)24(17)6-7-33-23(27)30-24)29-22(31)19-4-2-13(11-26)12-28-19/h2-5,8-10,12H,6-7H2,1H3,(H2,27,30)(H,29,31)
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n/an/a 1.47E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220775
PNG
(US9296759, 48)
Show SMILES CC#CCOc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(Cl)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C24H18ClFN6O4/c1-2-3-7-34-19-12-28-16(11-29-19)22(33)30-13-4-5-17-14(9-13)24(6-8-35-23(27)32-24)15-10-18(25)31-21(26)20(15)36-17/h4-5,9-12H,6-8H2,1H3,(H2,27,32)(H,30,33)
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n/an/a 1.52E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220858
PNG
(US9296759, 121)
Show SMILES COc1cnc(C(=O)Nc2ccc3Oc4c(F)nc(cc4C4(CCSC(N)=N4)c3c2)C2=CCOCC2)c(C)c1
Show InChI InChI=1S/C28H26FN5O4S/c1-15-11-18(36-2)14-31-23(15)26(35)32-17-3-4-22-19(12-17)28(7-10-39-27(30)34-28)20-13-21(16-5-8-37-9-6-16)33-25(29)24(20)38-22/h3-5,11-14H,6-10H2,1-2H3,(H2,30,34)(H,32,35)
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n/an/a 1.59E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220799
PNG
(US9296759, 67)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C26H23FN6O4S/c1-35-21-13-29-19(12-30-21)24(34)31-15-2-3-20-16(10-15)26(6-9-38-25(28)33-26)17-11-18(14-4-7-36-8-5-14)32-23(27)22(17)37-20/h2-4,10-13H,5-9H2,1H3,(H2,28,33)(H,31,34)
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n/an/a 1.60E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220852
PNG
(US9296759, 115)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)-c1ccnc(F)c1
Show InChI InChI=1S/C27H20F2N6O3S/c1-37-16-3-4-19(32-13-16)25(36)33-15-2-5-21-17(11-15)27(7-9-39-26(30)35-27)18-12-20(34-24(29)23(18)38-21)14-6-8-31-22(28)10-14/h2-6,8,10-13H,7,9H2,1H3,(H2,30,35)(H,33,36)
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n/an/a 1.62E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220847
PNG
(US9296759, 60)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)cc(cc3C3(CCSC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C27H24FN5O4S/c1-35-23-14-30-21(13-31-23)25(34)32-17-2-3-22-18(12-17)27(6-9-38-26(29)33-27)19-10-16(11-20(28)24(19)37-22)15-4-7-36-8-5-15/h2-4,10-14H,5-9H2,1H3,(H2,29,33)(H,32,34)
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n/an/a 1.74E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220798
PNG
(US9296759, 66)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C26H23FN6O4S/c1-35-21-12-29-19(11-30-21)24(34)31-15-4-5-20-16(9-15)26(6-8-38-25(28)33-26)17-10-18(14-3-2-7-36-13-14)32-23(27)22(17)37-20/h3-5,9-12H,2,6-8,13H2,1H3,(H2,28,33)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220812
PNG
(US9296759, 78)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3[C@]3(CCOC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C27H24FN5O5/c1-35-17-3-4-20(30-14-17)25(34)31-16-2-5-22-18(12-16)27(8-11-37-26(29)33-27)19-13-21(15-6-9-36-10-7-15)32-24(28)23(19)38-22/h2-6,12-14H,7-11H2,1H3,(H2,29,33)(H,31,34)/t27-/m0/s1
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n/an/a 1.84E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220836
PNG
(US9296759, 101)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C27H24FN5O4S/c1-35-17-3-4-20(30-14-17)25(34)31-16-2-5-22-18(12-16)27(8-11-38-26(29)33-27)19-13-21(15-6-9-36-10-7-15)32-24(28)23(19)37-22/h2-6,12-14H,7-11H2,1H3,(H2,29,33)(H,31,34)
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n/an/a 1.98E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220853
PNG
(US9296759, 116)
Show SMILES NC1=NC2(CCS1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c(F)nc(cc21)C1=CCOCC1
Show InChI InChI=1S/C26H21F2N5O3S/c27-15-1-3-19(30-13-15)24(34)31-16-2-4-21-17(11-16)26(7-10-37-25(29)33-26)18-12-20(14-5-8-35-9-6-14)32-23(28)22(18)36-21/h1-5,11-13H,6-10H2,(H2,29,33)(H,31,34)
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n/an/a 2.11E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220800
PNG
(US9296759, 68)
Show SMILES NC1=NC2(CCS1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c(F)nc(cc21)C1=CCCOC1
Show InChI InChI=1S/C26H21ClFN5O3S/c27-15-3-5-19(30-12-15)24(34)31-16-4-6-21-17(10-16)26(7-9-37-25(29)33-26)18-11-20(14-2-1-8-35-13-14)32-23(28)22(18)36-21/h2-6,10-12H,1,7-9,13H2,(H2,29,33)(H,31,34)
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n/an/a 2.17E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220849
PNG
(US9296759, 112)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)-c1cncc(F)c1
Show InChI InChI=1S/C26H19F2N7O3S/c1-37-21-12-31-19(11-32-21)24(36)33-15-2-3-20-16(7-15)26(4-5-39-25(29)35-26)17-8-18(34-23(28)22(17)38-20)13-6-14(27)10-30-9-13/h2-3,6-12H,4-5H2,1H3,(H2,29,35)(H,33,36)
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n/an/a 2.24E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220841
PNG
(US9296759, 105)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)cc(O)cc3C3(CCSC(N)=N3)c2c1
Show InChI InChI=1S/C23H19FN4O4S/c1-31-14-3-4-18(26-11-14)21(30)27-12-2-5-19-15(8-12)23(6-7-33-22(25)28-23)16-9-13(29)10-17(24)20(16)32-19/h2-5,8-11,29H,6-7H2,1H3,(H2,25,28)(H,27,30)
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n/an/a 2.25E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220846
PNG
(US9296759, 110)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)cc(cc3C3(CCSC(N)=N3)c2c1)N1CCOCC1
Show InChI InChI=1S/C26H25FN6O4S/c1-35-22-14-29-20(13-30-22)24(34)31-15-2-3-21-17(10-15)26(4-9-38-25(28)32-26)18-11-16(12-19(27)23(18)37-21)33-5-7-36-8-6-33/h2-3,10-14H,4-9H2,1H3,(H2,28,32)(H,31,34)
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n/an/a 2.30E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220769
PNG
(US9296759, 34)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1ncc(Br)cc21
Show InChI InChI=1S/C21H15BrClN5O3/c22-11-7-15-19(26-9-11)31-17-4-2-13(27-18(29)16-3-1-12(23)10-25-16)8-14(17)21(15)5-6-30-20(24)28-21/h1-4,7-10H,5-6H2,(H2,24,28)(H,27,29)
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n/an/a 2.45E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220817
PNG
(US9296759, 83)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c(F)nc(cc21)C1=CCCOC1
Show InChI InChI=1S/C26H21F2N5O4/c27-15-3-5-19(30-12-15)24(34)31-16-4-6-21-17(10-16)26(7-9-36-25(29)33-26)18-11-20(14-2-1-8-35-13-14)32-23(28)22(18)37-21/h2-6,10-12H,1,7-9,13H2,(H2,29,33)(H,31,34)
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n/an/a 2.55E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220821
PNG
(US9296759, 87)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)-c1cncc(F)c1
Show InChI InChI=1S/C27H20F2N6O4/c1-37-17-3-4-20(32-13-17)25(36)33-16-2-5-22-18(9-16)27(6-7-38-26(30)35-27)19-10-21(34-24(29)23(19)39-22)14-8-15(28)12-31-11-14/h2-5,8-13H,6-7H2,1H3,(H2,30,35)(H,33,36)
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n/an/a 2.56E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220793
PNG
(US9296759, 33)
Show SMILES CCOc1cccnc1Nc1ccc2Oc3c(F)cc(OC)cc3C3(CCSC(N)=N3)c2c1
Show InChI InChI=1S/C24H23FN4O3S/c1-3-31-20-5-4-9-27-22(20)28-14-6-7-19-16(11-14)24(8-10-33-23(26)29-24)17-12-15(30-2)13-18(25)21(17)32-19/h4-7,9,11-13H,3,8,10H2,1-2H3,(H2,26,29)(H,27,28)
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n/an/a 2.63E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220788
PNG
(US9296759, 54)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)C1CC1
Show InChI InChI=1S/C24H21FN6O4/c1-33-19-11-27-17(10-28-19)22(32)29-13-4-5-18-14(8-13)24(6-7-34-23(26)31-24)15-9-16(12-2-3-12)30-21(25)20(15)35-18/h4-5,8-12H,2-3,6-7H2,1H3,(H2,26,31)(H,29,32)
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n/an/a 2.69E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220840
PNG
(US9296759, 104)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3cnc(cc3C3(CCSC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C26H24N6O4S/c1-34-23-13-29-20(11-30-23)24(33)31-16-4-5-21-17(9-16)26(6-8-37-25(27)32-26)18-10-19(28-12-22(18)36-21)15-3-2-7-35-14-15/h3-5,9-13H,2,6-8,14H2,1H3,(H2,27,32)(H,31,33)
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n/an/a 2.95E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220856
PNG
(US9296759, 119)
Show SMILES NC1=NC2(CCS1)c1cc(NC(=O)c3ncc(Cl)cc3F)ccc1Oc1c(F)nc(cc21)C1=CCOCC1
Show InChI InChI=1S/C26H20ClF2N5O3S/c27-14-9-18(28)21(31-12-14)24(35)32-15-1-2-20-16(10-15)26(5-8-38-25(30)34-26)17-11-19(13-3-6-36-7-4-13)33-23(29)22(17)37-20/h1-3,9-12H,4-8H2,(H2,30,34)(H,32,35)
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n/an/a 3.11E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220818
PNG
(US9296759, 84)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C27H24FN5O5/c1-35-17-5-6-20(30-13-17)25(34)31-16-4-7-22-18(11-16)27(8-10-37-26(29)33-27)19-12-21(15-3-2-9-36-14-15)32-24(28)23(19)38-22/h3-7,11-13H,2,8-10,14H2,1H3,(H2,29,33)(H,31,34)
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n/an/a 3.13E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220776
PNG
(US9296759, 49)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3cnc(Cl)cn3)ccc1Oc1c(F)nc(Cl)cc21
Show InChI InChI=1S/C20H13Cl2FN6O3/c21-14-6-11-16(17(23)28-14)32-13-2-1-9(27-18(30)12-7-26-15(22)8-25-12)5-10(13)20(11)3-4-31-19(24)29-20/h1-2,5-8H,3-4H2,(H2,24,29)(H,27,30)
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n/an/a 3.23E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220843
PNG
(US9296759, 107)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)cc(cc3C3(CCSC(N)=N3)c2c1)N1CCOCC1
Show InChI InChI=1S/C27H26FN5O4S/c1-35-18-3-4-22(30-15-18)25(34)31-16-2-5-23-19(12-16)27(6-11-38-26(29)32-27)20-13-17(14-21(28)24(20)37-23)33-7-9-36-10-8-33/h2-5,12-15H,6-11H2,1H3,(H2,29,32)(H,31,34)
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n/an/a 3.26E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220811
PNG
(US9296759, 77)
Show SMILES COc1ccc(C(=O)Nc2ccc3Oc4c(F)cc(OC)cc4C4(CCOC(N)=N4)c3c2)c(F)c1
Show InChI InChI=1S/C25H21F2N3O5/c1-32-14-4-5-16(19(26)11-14)23(31)29-13-3-6-21-17(9-13)25(7-8-34-24(28)30-25)18-10-15(33-2)12-20(27)22(18)35-21/h3-6,9-12H,7-8H2,1-2H3,(H2,28,30)(H,29,31)
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n/an/a 3.31E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220774
PNG
(US9296759, 47)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(Cl)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C21H16ClFN6O4/c1-31-16-9-25-13(8-26-16)19(30)27-10-2-3-14-11(6-10)21(4-5-32-20(24)29-21)12-7-15(22)28-18(23)17(12)33-14/h2-3,6-9H,4-5H2,1H3,(H2,24,29)(H,27,30)
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n/an/a 3.35E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220779
PNG
(US9296759, 45)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1ncc(cc21)C1=CCOCC1
Show InChI InChI=1S/C26H22ClN5O4/c27-17-1-3-21(29-14-17)23(33)31-18-2-4-22-19(12-18)26(7-10-35-25(28)32-26)20-11-16(13-30-24(20)36-22)15-5-8-34-9-6-15/h1-5,11-14H,6-10H2,(H2,28,32)(H,31,33)
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n/an/a 3.42E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220777
PNG
(US9296759, 32)
Show SMILES COc1cc(F)c2Oc3ccc(NC(=O)c4ccc(Cl)cn4)cc3C3(CCSC(N)=N3)c2c1
Show InChI InChI=1S/C23H18ClFN4O3S/c1-31-14-9-16-20(17(25)10-14)32-19-5-3-13(28-21(30)18-4-2-12(24)11-27-18)8-15(19)23(16)6-7-33-22(26)29-23/h2-5,8-11H,6-7H2,1H3,(H2,26,29)(H,28,30)
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n/an/a 3.50E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220804
PNG
(US9296759, 72)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3cnc(F)cn3)ccc1Oc1c(F)nc(cc21)-c1cccnc1
Show InChI InChI=1S/C25H17F2N7O3/c26-20-12-30-18(11-31-20)23(35)32-14-3-4-19-15(8-14)25(5-7-36-24(28)34-25)16-9-17(13-2-1-6-29-10-13)33-22(27)21(16)37-19/h1-4,6,8-12H,5,7H2,(H2,28,34)(H,32,35)
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n/an/a 3.58E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220787
PNG
(US9296759, 40)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c(F)nc(cc21)C1CC1
Show InChI InChI=1S/C24H19ClFN5O3/c25-13-3-5-17(28-11-13)22(32)29-14-4-6-19-15(9-14)24(7-8-33-23(27)31-24)16-10-18(12-1-2-12)30-21(26)20(16)34-19/h3-6,9-12H,1-2,7-8H2,(H2,27,31)(H,29,32)
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n/an/a 3.60E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220822
PNG
(US9296759, 88)
Show SMILES Cc1nc(cs1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)-c1cncc(F)c1
Show InChI InChI=1S/C25H18F2N6O3S/c1-12-30-19(11-37-12)23(34)31-15-2-3-20-16(7-15)25(4-5-35-24(28)33-25)17-8-18(32-22(27)21(17)36-20)13-6-14(26)10-29-9-13/h2-3,6-11H,4-5H2,1H3,(H2,28,33)(H,31,34)
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n/an/a 3.62E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220837
PNG
(US9296759, 61)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)cc(cc3C3(CCOC(N)=N3)c2c1)C1CCOCC1
Show InChI InChI=1S/C27H26FN5O5/c1-35-23-14-30-21(13-31-23)25(34)32-17-2-3-22-18(12-17)27(6-9-37-26(29)33-27)19-10-16(11-20(28)24(19)38-22)15-4-7-36-8-5-15/h2-3,10-15H,4-9H2,1H3,(H2,29,33)(H,32,34)
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n/an/a 3.79E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220792
PNG
(US9296759, 41)
Show SMILES Cc1cccnc1Nc1ccc2Oc3c(F)nc(Cl)cc3[C@]3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C21H17ClFN5O2/c1-11-3-2-7-25-19(11)26-12-4-5-15-13(9-12)21(6-8-29-20(24)28-21)14-10-16(22)27-18(23)17(14)30-15/h2-5,7,9-10H,6,8H2,1H3,(H2,24,28)(H,25,26)/t21-/m0/s1
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n/an/a 3.86E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220780
PNG
(US9296759, 42)
Show SMILES COc1cc(F)c2Oc3ccc(NC(=O)c4ccc(Cl)cn4)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C23H18ClFN4O4/c1-31-14-9-16-20(17(25)10-14)33-19-5-3-13(28-21(30)18-4-2-12(24)11-27-18)8-15(19)23(16)6-7-32-22(26)29-23/h2-5,8-11H,6-7H2,1H3,(H2,26,29)(H,28,30)
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n/an/a>4.00E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220796
PNG
(US9296759, 64)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(cn3)C#N)ccc1Oc1c(F)nc(cc21)C1=CCOCC1
Show InChI InChI=1S/C27H21FN6O4/c28-24-23-19(12-21(33-24)16-5-8-36-9-6-16)27(7-10-37-26(30)34-27)18-11-17(2-4-22(18)38-23)32-25(35)20-3-1-15(13-29)14-31-20/h1-5,11-12,14H,6-10H2,(H2,30,34)(H,32,35)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


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More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220802
PNG
(US9296759, 70)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)-c1cncc(F)c1
Show InChI InChI=1S/C26H19F2N7O4/c1-37-21-12-31-19(11-32-21)24(36)33-15-2-3-20-16(7-15)26(4-5-38-25(29)35-26)17-8-18(34-23(28)22(17)39-20)13-6-14(27)10-30-9-13/h2-3,6-12H,4-5H2,1H3,(H2,29,35)(H,33,36)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220815
PNG
(US9296759, 81)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1cnc(cc21)C1CC1
Show InChI InChI=1S/C24H20ClN5O3/c25-14-3-5-18(27-11-14)22(31)29-15-4-6-20-16(9-15)24(7-8-32-23(26)30-24)17-10-19(13-1-2-13)28-12-21(17)33-20/h3-6,9-13H,1-2,7-8H2,(H2,26,30)(H,29,31)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220816
PNG
(US9296759, 82)
Show SMILES CC(C)(C)C#Cc1cc2c(Oc3ccc(NC(=O)c4ccc(Cl)cn4)cc3C22CCOC(N)=N2)cn1
Show InChI InChI=1S/C27H24ClN5O3/c1-26(2,3)9-8-17-12-20-23(15-30-17)36-22-7-5-18(32-24(34)21-6-4-16(28)14-31-21)13-19(22)27(20)10-11-35-25(29)33-27/h4-7,12-15H,10-11H2,1-3H3,(H2,29,33)(H,32,34)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220826
PNG
(US9296759, 92)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)-c1ccnc(F)c1
Show InChI InChI=1S/C26H19F2N7O4/c1-37-21-12-31-18(11-32-21)24(36)33-14-2-3-19-15(9-14)26(5-7-38-25(29)35-26)16-10-17(34-23(28)22(16)39-19)13-4-6-30-20(27)8-13/h2-4,6,8-12H,5,7H2,1H3,(H2,29,35)(H,33,36)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220827
PNG
(US9296759, 93)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3cnc(cc3C3(CCOC(N)=N3)c2c1)-c1ccnc(F)c1
Show InChI InChI=1S/C26H20FN7O4/c1-36-23-13-31-19(11-32-23)24(35)33-15-2-3-20-16(9-15)26(5-7-37-25(28)34-26)17-10-18(30-12-21(17)38-20)14-4-6-29-22(27)8-14/h2-4,6,8-13H,5,7H2,1H3,(H2,28,34)(H,33,35)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220829
PNG
(US9296759, 95)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)cc(cc3C3(CCOC(N)=N3)c2c1)-c1ccnc(F)c1
Show InChI InChI=1S/C27H20F2N6O4/c1-37-23-13-32-20(12-33-23)25(36)34-16-2-3-21-17(11-16)27(5-7-38-26(30)35-27)18-8-15(9-19(28)24(18)39-21)14-4-6-31-22(29)10-14/h2-4,6,8-13H,5,7H2,1H3,(H2,30,35)(H,34,36)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220830
PNG
(US9296759, 62)
Show SMILES COc1nc(cc2c1Oc1ccc(NC(=O)c3ccc(Cl)cn3)cc1C21CCOC(N)=N1)C1=CCOCC1
Show InChI InChI=1S/C27H24ClN5O5/c1-35-25-23-19(13-21(32-25)15-6-9-36-10-7-15)27(8-11-37-26(29)33-27)18-12-17(3-5-22(18)38-23)31-24(34)20-4-2-16(28)14-30-20/h2-6,12-14H,7-11H2,1H3,(H2,29,33)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220831
PNG
(US9296759, 96)
Show SMILES COc1nc(cc2c1Oc1ccc(NC(=O)c3ccc(F)cn3)cc1C21CCOC(N)=N1)C1=CCOCC1
Show InChI InChI=1S/C27H24FN5O5/c1-35-25-23-19(13-21(32-25)15-6-9-36-10-7-15)27(8-11-37-26(29)33-27)18-12-17(3-5-22(18)38-23)31-24(34)20-4-2-16(28)14-30-20/h2-6,12-14H,7-11H2,1H3,(H2,29,33)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220790
PNG
(US9296759, 55 | US9296759, 56)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(Cl)cc3C3(CCSC(N)=N3)c2c1
Show InChI InChI=1S/C21H16ClFN6O3S/c1-31-16-9-25-13(8-26-16)19(30)27-10-2-3-14-11(6-10)21(4-5-33-20(24)29-21)12-7-15(22)28-18(23)17(12)32-14/h2-3,6-9H,4-5H2,1H3,(H2,24,29)(H,27,30)
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US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220825
PNG
(US9296759, 91)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c(F)nc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C26H17ClF2N6O3/c27-14-1-3-18(32-12-14)24(36)33-15-2-4-20-16(10-15)26(6-8-37-25(30)35-26)17-11-19(34-23(29)22(17)38-20)13-5-7-31-21(28)9-13/h1-5,7,9-12H,6,8H2,(H2,30,35)(H,33,36)
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US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220844
PNG
(US9296759, 108)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(cn3)C#N)ccc1Oc1c(F)cc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C28H18F2N6O3/c29-21-10-17(16-5-7-33-24(30)11-16)9-20-25(21)39-23-4-2-18(12-19(23)28(20)6-8-38-27(32)36-28)35-26(37)22-3-1-15(13-31)14-34-22/h1-5,7,9-12,14H,6,8H2,(H2,32,36)(H,35,37)
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US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220851
PNG
(US9296759, 114)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)-c1ccnc(F)c1
Show InChI InChI=1S/C26H19F2N7O3S/c1-37-21-12-31-18(11-32-21)24(36)33-14-2-3-19-15(9-14)26(5-7-39-25(29)35-26)16-10-17(34-23(28)22(16)38-19)13-4-6-30-20(27)8-13/h2-4,6,8-12H,5,7H2,1H3,(H2,29,35)(H,33,36)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220784
PNG
(US9296759, 51)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C26H23FN6O5/c1-35-21-12-29-19(11-30-21)24(34)31-15-4-5-20-16(9-15)26(6-8-37-25(28)33-26)17-10-18(14-3-2-7-36-13-14)32-23(27)22(17)38-20/h3-5,9-12H,2,6-8,13H2,1H3,(H2,28,33)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220795
PNG
(US9296759, 31)
Show SMILES CCOc1cccnc1Nc1ccc2Oc3c(F)cc(OC)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C24H23FN4O4/c1-3-31-20-5-4-9-27-22(20)28-14-6-7-19-16(11-14)24(8-10-32-23(26)29-24)17-12-15(30-2)13-18(25)21(17)33-19/h4-7,9,11-13H,3,8,10H2,1-2H3,(H2,26,29)(H,27,28)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220803
PNG
(US9296759, 71)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3cnc(Cl)cn3)ccc1Oc1c(F)nc(cc21)-c1cncc(F)c1
Show InChI InChI=1S/C25H16ClF2N7O3/c26-20-11-31-18(10-32-20)23(36)33-14-1-2-19-15(6-14)25(3-4-37-24(29)35-25)16-7-17(34-22(28)21(16)38-19)12-5-13(27)9-30-8-12/h1-2,5-11H,3-4H2,(H2,29,35)(H,33,36)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220773
PNG
(US9296759, 46)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(cn3)C#N)ccc1Oc1c(F)nc(Cl)cc21
Show InChI InChI=1S/C22H14ClFN6O3/c23-17-8-14-18(19(24)29-17)33-16-4-2-12(7-13(16)22(14)5-6-32-21(26)30-22)28-20(31)15-3-1-11(9-25)10-27-15/h1-4,7-8,10H,5-6H2,(H2,26,30)(H,28,31)
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US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220832
PNG
(US9296759, 97)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c(F)nc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C26H17F3N6O3/c27-14-1-3-18(32-12-14)24(36)33-15-2-4-20-16(10-15)26(6-8-37-25(30)35-26)17-11-19(34-23(29)22(17)38-20)13-5-7-31-21(28)9-13/h1-5,7,9-12H,6,8H2,(H2,30,35)(H,33,36)
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US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220809
PNG
(US9296759, 75)
Show SMILES COc1cc(F)c2Oc3ccc(NC(=O)c4cnc(OC)cn4)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C23H20FN5O5/c1-31-13-8-15-20(16(24)9-13)34-18-4-3-12(7-14(18)23(15)5-6-33-22(25)29-23)28-21(30)17-10-27-19(32-2)11-26-17/h3-4,7-11H,5-6H2,1-2H3,(H2,25,29)(H,28,30)
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US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220797
PNG
(US9296759, 65)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C26H23FN6O5/c1-35-21-13-29-19(12-30-21)24(34)31-15-2-3-20-16(10-15)26(6-9-37-25(28)33-26)17-11-18(14-4-7-36-8-5-14)32-23(27)22(17)38-20/h2-4,10-13H,5-9H2,1H3,(H2,28,33)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220833
PNG
(US9296759, 98)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)-c1ccnc(F)c1
Show InChI InChI=1S/C27H20F2N6O4/c1-37-16-3-4-19(32-13-16)25(36)33-15-2-5-21-17(11-15)27(7-9-38-26(30)35-27)18-12-20(34-24(29)23(18)39-21)14-6-8-31-22(28)10-14/h2-6,8,10-13H,7,9H2,1H3,(H2,30,35)(H,33,36)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220781
PNG
(US9296759, 36)
Show SMILES NC1=NC2(CCO1)c1cccnc1Oc1ccc(NC(=O)c3ccc(Cl)cn3)cc21
Show InChI InChI=1S/C21H16ClN5O3/c22-12-3-5-16(25-11-12)18(28)26-13-4-6-17-15(10-13)21(7-9-29-20(23)27-21)14-2-1-8-24-19(14)30-17/h1-6,8,10-11H,7,9H2,(H2,23,27)(H,26,28)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220783
PNG
(US9296759, 39)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c(F)nc(cc21)C1=CCCOC1
Show InChI InChI=1S/C26H21ClFN5O4/c27-15-3-5-19(30-12-15)24(34)31-16-4-6-21-17(10-16)26(7-9-36-25(29)33-26)18-11-20(14-2-1-8-35-13-14)32-23(28)22(18)37-21/h2-6,10-12H,1,7-9,13H2,(H2,29,33)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220794
PNG
(US9296759, 57)
Show SMILES COc1cc(F)c2Oc3ccc(Nc4ncccc4OCc4ccccc4)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C29H25FN4O4/c1-35-20-15-22-26(23(30)16-20)38-24-10-9-19(14-21(24)29(22)11-13-36-28(31)34-29)33-27-25(8-5-12-32-27)37-17-18-6-3-2-4-7-18/h2-10,12,14-16H,11,13,17H2,1H3,(H2,31,34)(H,32,33)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220839
PNG
(US9296759, 103)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3cnc(cc3C3(CCSC(N)=N3)c2c1)C1=CCOCC1
Show InChI InChI=1S/C26H24N6O4S/c1-34-23-14-29-20(12-30-23)24(33)31-16-2-3-21-17(10-16)26(6-9-37-25(27)32-26)18-11-19(28-13-22(18)36-21)15-4-7-35-8-5-15/h2-4,10-14H,5-9H2,1H3,(H2,27,32)(H,31,33)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220834
PNG
(US9296759, 99)
Show SMILES Cc1nc(cs1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)-c1ccnc(F)c1
Show InChI InChI=1S/C25H18F2N6O3S/c1-12-30-18(11-37-12)23(34)31-14-2-3-19-15(9-14)25(5-7-35-24(28)33-25)16-10-17(32-22(27)21(16)36-19)13-4-6-29-20(26)8-13/h2-4,6,8-11H,5,7H2,1H3,(H2,28,33)(H,31,34)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220828
PNG
(US9296759, 94)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1cnc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C26H18ClFN6O3/c27-15-1-3-19(31-12-15)24(35)33-16-2-4-21-17(10-16)26(6-8-36-25(29)34-26)18-11-20(32-13-22(18)37-21)14-5-7-30-23(28)9-14/h1-5,7,9-13H,6,8H2,(H2,29,34)(H,33,35)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220813
PNG
(US9296759, 79)
Show SMILES NC1=NC2(CCO1)c1cc(Cl)ncc1Oc1ccc(NC(=O)c3ccc(Cl)cn3)cc21
Show InChI InChI=1S/C21H15Cl2N5O3/c22-11-1-3-15(25-9-11)19(29)27-12-2-4-16-13(7-12)21(5-6-30-20(24)28-21)14-8-18(23)26-10-17(14)31-16/h1-4,7-10H,5-6H2,(H2,24,28)(H,27,29)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220810
PNG
(US9296759, 76)
Show SMILES COc1cc(F)c2Oc3ccc(NC(=O)c4ccc(Cl)cc4F)cc3C3(CCOC(N)=N3)c2c1
Show InChI InChI=1S/C24H18ClF2N3O4/c1-32-14-10-17-21(19(27)11-14)34-20-5-3-13(9-16(20)24(17)6-7-33-23(28)30-24)29-22(31)15-4-2-12(25)8-18(15)26/h2-5,8-11H,6-7H2,1H3,(H2,28,30)(H,29,31)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220768
PNG
(US9296759, 63)
Show SMILES NC1=N[C@@]2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c(F)nc(cc21)C1=CCOCC1
Show InChI InChI=1S/C26H21ClFN5O4/c27-15-1-3-19(30-13-15)24(34)31-16-2-4-21-17(11-16)26(7-10-36-25(29)33-26)18-12-20(14-5-8-35-9-6-14)32-23(28)22(18)37-21/h1-5,11-13H,6-10H2,(H2,29,33)(H,31,34)/t26-/m0/s1
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220767
PNG
(US9296759, 59)
Show SMILES Cc1ccc(nc1)C(=O)Nc1ccc2Oc3cnc(cc3[C@]3(CCOC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C27H25N5O4/c1-16-4-6-21(29-13-16)25(33)31-18-5-7-23-19(11-18)27(8-10-35-26(28)32-27)20-12-22(30-14-24(20)36-23)17-3-2-9-34-15-17/h3-7,11-14H,2,8-10,15H2,1H3,(H2,28,32)(H,31,33)/t27-/m0/s1
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220782
PNG
(US9296759, 37)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cc3F)ccc1Oc1ncc(Br)cc21
Show InChI InChI=1S/C22H15BrClFN4O3/c23-11-7-16-20(27-10-11)32-18-4-2-13(9-15(18)22(16)5-6-31-21(26)29-22)28-19(30)14-3-1-12(24)8-17(14)25/h1-4,7-10H,5-6H2,(H2,26,29)(H,28,30)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220806
PNG
(US9296759, 59)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1cnc(cc21)C1=CCCOC1
Show InChI InChI=1S/C26H22ClN5O4/c27-16-3-5-20(29-12-16)24(33)31-17-4-6-22-18(10-17)26(7-9-35-25(28)32-26)19-11-21(30-13-23(19)36-22)15-2-1-8-34-14-15/h2-6,10-13H,1,7-9,14H2,(H2,28,32)(H,31,33)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220838
PNG
(US9296759, 102)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c(F)cc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C27H18F3N5O3/c28-16-1-3-21(33-13-16)25(36)34-17-2-4-22-18(12-17)27(6-8-37-26(31)35-27)19-9-15(10-20(29)24(19)38-22)14-5-7-32-23(30)11-14/h1-5,7,9-13H,6,8H2,(H2,31,35)(H,34,36)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220855
PNG
(US9296759, 118)
Show SMILES NC1=NC2(CCS1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c(F)nc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C26H17F3N6O2S/c27-14-1-3-18(32-12-14)24(36)33-15-2-4-20-16(10-15)26(6-8-38-25(30)35-26)17-11-19(34-23(29)22(17)37-20)13-5-7-31-21(28)9-13/h1-5,7,9-12H,6,8H2,(H2,30,35)(H,33,36)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220772
PNG
(US9296759, 38)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c(F)nc(Cl)cc21
Show InChI InChI=1S/C21H14Cl2FN5O3/c22-10-1-3-14(26-9-10)19(30)27-11-2-4-15-12(7-11)21(5-6-31-20(25)29-21)13-8-16(23)28-18(24)17(13)32-15/h1-4,7-9H,5-6H2,(H2,25,29)(H,27,30)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220786
PNG
(US9296759, 53)
Show SMILES COc1nc(cc2c1Oc1ccc(NC(=O)c3ccc(Cl)cn3)cc1C21CCOC(N)=N1)C1CC1
Show InChI InChI=1S/C25H22ClN5O4/c1-33-23-21-17(11-19(30-23)13-2-3-13)25(8-9-34-24(27)31-25)16-10-15(5-7-20(16)35-21)29-22(32)18-6-4-14(26)12-28-18/h4-7,10-13H,2-3,8-9H2,1H3,(H2,27,31)(H,29,32)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220823
PNG
(US9296759, 89)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c(F)nc(cc21)-c1cncc(F)c1
Show InChI InChI=1S/C26H17F3N6O3/c27-14-1-3-19(32-12-14)24(36)33-16-2-4-21-17(8-16)26(5-6-37-25(30)35-26)18-9-20(34-23(29)22(18)38-21)13-7-15(28)11-31-10-13/h1-4,7-12H,5-6H2,(H2,30,35)(H,33,36)
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Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220845
PNG
(US9296759, 109)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)cc(O)cc3C3(CCSC(N)=N3)c2c1
Show InChI InChI=1S/C22H18FN5O4S/c1-31-18-10-25-16(9-26-18)20(30)27-11-2-3-17-13(6-11)22(4-5-33-21(24)28-22)14-7-12(29)8-15(23)19(14)32-17/h2-3,6-10,29H,4-5H2,1H3,(H2,24,28)(H,27,30)
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n/an/a 4.00E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220778
PNG
(US9296759, 50)
Show SMILES COc1cc(F)c2Oc3ccc(NC(=O)c4cnc(OC)cn4)cc3C3(CCSC(N)=N3)c2c1
Show InChI InChI=1S/C23H20FN5O4S/c1-31-13-8-15-20(16(24)9-13)33-18-4-3-12(7-14(18)23(15)5-6-34-22(25)29-23)28-21(30)17-10-27-19(32-2)11-26-17/h3-4,7-11H,5-6H2,1-2H3,(H2,25,29)(H,28,30)
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n/an/a>4.00E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220824
PNG
(US9296759, 90)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1ncc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C26H18ClFN6O3/c27-16-1-3-20(31-13-16)23(35)33-17-2-4-21-18(11-17)26(6-8-36-25(29)34-26)19-9-15(12-32-24(19)37-21)14-5-7-30-22(28)10-14/h1-5,7,9-13H,6,8H2,(H2,29,34)(H,33,35)
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n/an/a 4.01E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220819
PNG
(US9296759, 85)
Show SMILES Cc1nc(cs1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCOC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C25H22FN5O4S/c1-13-28-19(12-36-13)23(32)29-15-4-5-20-16(9-15)25(6-8-34-24(27)31-25)17-10-18(14-3-2-7-33-11-14)30-22(26)21(17)35-20/h3-5,9-10,12H,2,6-8,11H2,1H3,(H2,27,31)(H,29,32)
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n/an/a 4.11E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220807
PNG
(US9296759, 73)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1ncc(cc21)C1CC1
Show InChI InChI=1S/C24H20ClN5O3/c25-15-3-5-19(27-12-15)21(31)29-16-4-6-20-17(10-16)24(7-8-32-23(26)30-24)18-9-14(13-1-2-13)11-28-22(18)33-20/h3-6,9-13H,1-2,7-8H2,(H2,26,30)(H,29,31)
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n/an/a 4.33E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220820
PNG
(US9296759, 86)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3cnc(cc3C3(CCOC(N)=N3)c2c1)C#CC(C)(C)C
Show InChI InChI=1S/C27H26N6O4/c1-26(2,3)8-7-16-11-19-22(14-29-16)37-21-6-5-17(12-18(21)27(19)9-10-36-25(28)33-27)32-24(34)20-13-31-23(35-4)15-30-20/h5-6,11-15H,9-10H2,1-4H3,(H2,28,33)(H,32,34)
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n/an/a 4.52E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220766
PNG
(US9296759, 58)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3cnc(cc3[C@]3(CCOC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C26H24N6O5/c1-34-23-13-29-20(11-30-23)24(33)31-16-4-5-21-17(9-16)26(6-8-36-25(27)32-26)18-10-19(28-12-22(18)37-21)15-3-2-7-35-14-15/h3-5,9-13H,2,6-8,14H2,1H3,(H2,27,32)(H,31,33)/t26-/m0/s1
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n/an/a 4.80E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220805
PNG
(US9296759, 58)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3cnc(cc3C3(CCOC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C26H24N6O5/c1-34-23-13-29-20(11-30-23)24(33)31-16-4-5-21-17(9-16)26(6-8-36-25(27)32-26)18-10-19(28-12-22(18)37-21)15-3-2-7-35-14-15/h3-5,9-13H,2,6-8,14H2,1H3,(H2,27,32)(H,31,33)
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n/an/a 4.80E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220835
PNG
(US9296759, 100)
Show SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(cn3)C#N)ccc1Oc1c(F)nc(cc21)-c1ccnc(F)c1
Show InChI InChI=1S/C27H17F2N7O3/c28-22-9-15(5-7-32-22)20-11-18-23(24(29)35-20)39-21-4-2-16(10-17(21)27(18)6-8-38-26(31)36-27)34-25(37)19-3-1-14(12-30)13-33-19/h1-5,7,9-11,13H,6,8H2,(H2,31,36)(H,34,37)
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n/an/a 5.18E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220848
PNG
(US9296759, 111)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)C1=CCCOC1
Show InChI InChI=1S/C27H24FN5O4S/c1-35-17-5-6-20(30-13-17)25(34)31-16-4-7-22-18(11-16)27(8-10-38-26(29)33-27)19-12-21(15-3-2-9-36-14-15)32-24(28)23(19)37-22/h3-7,11-13H,2,8-10,14H2,1H3,(H2,29,33)(H,31,34)
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n/an/a 5.69E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM220814
PNG
(US9296759, 80)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3cnc(cc3C3(CCOC(N)=N3)c2c1)C1CC1
Show InChI InChI=1S/C24H22N6O4/c1-32-21-12-27-18(10-28-21)22(31)29-14-4-5-19-15(8-14)24(6-7-33-23(25)30-24)16-9-17(13-2-3-13)26-11-20(16)34-19/h4-5,8-13H,2-3,6-7H2,1H3,(H2,25,30)(H,29,31)
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n/an/a 9.63E+5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%