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Patent code US9303023

Compile Data Set for Download or QSAR
Found 145 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Orexin receptor 2


(Homo sapiens (Human))
BDBM221340
PNG
(US9303023, 39)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(Cl)c4)cn3)c2c1
Show InChI InChI=1S/C24H20ClN5O3/c1-32-19-5-6-21-20(10-19)16(11-26-21)7-8-30-13-18(12-28-30)29-24(31)22-23(33-14-27-22)15-3-2-4-17(25)9-15/h2-6,9-14,26H,7-8H2,1H3,(H,29,31)
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n/an/a 2n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221328
PNG
(US9303023, 27)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4ccccc4)cn3)c2c1
Show InChI InChI=1S/C24H21N5O3/c1-31-19-7-8-21-20(11-19)17(12-25-21)9-10-29-14-18(13-27-29)28-24(30)22-23(32-15-26-22)16-5-3-2-4-6-16/h2-8,11-15,25H,9-10H2,1H3,(H,28,30)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221360
PNG
(US9303023, 56)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1
Show InChI InChI=1S/C25H23N5O3/c1-16-4-3-5-17(10-16)24-23(27-15-33-24)25(31)29-19-13-28-30(14-19)9-8-18-12-26-22-7-6-20(32-2)11-21(18)22/h3-7,10-15,26H,8-9H2,1-2H3,(H,29,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221381
PNG
(US9303023, 78)
Show SMILES COc1ccc2ccn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2n1
Show InChI InChI=1S/C24H22N6O3/c1-16-4-3-5-18(12-16)22-21(25-15-33-22)24(31)27-19-13-26-30(14-19)11-10-29-9-8-17-6-7-20(32-2)28-23(17)29/h3-9,12-15H,10-11H2,1-2H3,(H,27,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221327
PNG
(US9303023, 26)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(F)c4)cn3)c2c1
Show InChI InChI=1S/C24H20FN5O3/c1-32-19-5-6-21-20(10-19)16(11-26-21)7-8-30-13-18(12-28-30)29-24(31)22-23(33-14-27-22)15-3-2-4-17(25)9-15/h2-6,9-14,26H,7-8H2,1H3,(H,29,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221368
PNG
(US9303023, 64)
Show SMILES COc1ccc2ncn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1
Show InChI InChI=1S/C24H22N6O3/c1-16-4-3-5-17(10-16)23-22(26-15-33-23)24(31)28-18-12-27-30(13-18)9-8-29-14-25-20-7-6-19(32-2)11-21(20)29/h3-7,10-15H,8-9H2,1-2H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221330
PNG
(US9303023, 29)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4ccccc4F)cn3)c2c1
Show InChI InChI=1S/C24H20FN5O3/c1-32-17-6-7-21-19(10-17)15(11-26-21)8-9-30-13-16(12-28-30)29-24(31)22-23(33-14-27-22)18-4-2-3-5-20(18)25/h2-7,10-14,26H,8-9H2,1H3,(H,29,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221408
PNG
(US9303023, 105)
Show SMILES COc1ccc2ccn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1
Show InChI InChI=1S/C25H23N5O3/c1-17-4-3-5-19(12-17)24-23(26-16-33-24)25(31)28-20-14-27-30(15-20)11-10-29-9-8-18-6-7-21(32-2)13-22(18)29/h3-9,12-16H,10-11H2,1-2H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221386
PNG
(US9303023, 83)
Show SMILES COc1cc(OC)c2ccn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1
Show InChI InChI=1S/C26H25N5O4/c1-17-5-4-6-18(11-17)25-24(27-16-35-25)26(32)29-19-14-28-31(15-19)10-9-30-8-7-21-22(30)12-20(33-2)13-23(21)34-3/h4-8,11-16H,9-10H2,1-3H3,(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221338
PNG
(US9303023, 37)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(OC(F)(F)F)c4)cn3)c2c1
Show InChI InChI=1S/C25H20F3N5O4/c1-35-18-5-6-21-20(10-18)16(11-29-21)7-8-33-13-17(12-31-33)32-24(34)22-23(36-14-30-22)15-3-2-4-19(9-15)37-25(26,27)28/h2-6,9-14,29H,7-8H2,1H3,(H,32,34)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221367
PNG
(US9303023, 63)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2n1
Show InChI InChI=1S/C24H22N6O3/c1-15-4-3-5-16(10-15)23-22(26-14-33-23)24(31)28-18-12-27-30(13-18)9-8-17-11-25-19-6-7-20(32-2)29-21(17)19/h3-7,10-14,25H,8-9H2,1-2H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221339
PNG
(US9303023, 38)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(c4)C(F)(F)F)cn3)c2c1
Show InChI InChI=1S/C25H20F3N5O3/c1-35-19-5-6-21-20(10-19)16(11-29-21)7-8-33-13-18(12-31-33)32-24(34)22-23(36-14-30-22)15-3-2-4-17(9-15)25(26,27)28/h2-6,9-14,29H,7-8H2,1H3,(H,32,34)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221348
PNG
(US9303023, 144)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cc(C)no4)cn3)c2c1
Show InChI InChI=1S/C22H20N6O4/c1-13-7-19(32-27-13)21-20(24-12-31-21)22(29)26-15-10-25-28(11-15)6-5-14-9-23-18-4-3-16(30-2)8-17(14)18/h3-4,7-12,23H,5-6H2,1-2H3,(H,26,29)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221413
PNG
(US9303023, 110)
Show SMILES COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1
Show InChI InChI=1S/C22H23N7O4/c1-14-5-4-6-15(9-14)20-19(24-13-33-20)21(30)26-16-11-25-29(12-16)8-7-23-22-27-17(31-2)10-18(28-22)32-3/h4-6,9-13H,7-8H2,1-3H3,(H,26,30)(H,23,27,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221344
PNG
(US9303023, 43)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncsc4-c4cccc(Cl)c4)cn3)c2c1
Show InChI InChI=1S/C24H20ClN5O2S/c1-32-19-5-6-21-20(10-19)16(11-26-21)7-8-30-13-18(12-28-30)29-24(31)22-23(33-14-27-22)15-3-2-4-17(25)9-15/h2-6,9-14,26H,7-8H2,1H3,(H,29,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221365
PNG
(US9303023, 61)
Show SMILES COc1ccc2n(C)cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1
Show InChI InChI=1S/C26H25N5O3/c1-17-5-4-6-18(11-17)25-24(27-16-34-25)26(32)29-20-13-28-31(15-20)10-9-19-14-30(2)23-8-7-21(33-3)12-22(19)23/h4-8,11-16H,9-10H2,1-3H3,(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221332
PNG
(US9303023, 31)
Show SMILES COc1cc2ccn(CCn3cc(NC(=O)c4ncoc4-c4ccc(C)c(C)c4)cn3)c2cc1OC
Show InChI InChI=1S/C27H27N5O4/c1-17-5-6-20(11-18(17)2)26-25(28-16-36-26)27(33)30-21-14-29-32(15-21)10-9-31-8-7-19-12-23(34-3)24(35-4)13-22(19)31/h5-8,11-16H,9-10H2,1-4H3,(H,30,33)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221356
PNG
(US9303023, 52)
Show SMILES COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(F)c3)cn2)n1
Show InChI InChI=1S/C21H20FN7O4/c1-31-16-9-17(32-2)28-21(27-16)23-6-7-29-11-15(10-25-29)26-20(30)18-19(33-12-24-18)13-4-3-5-14(22)8-13/h3-5,8-12H,6-7H2,1-2H3,(H,26,30)(H,23,27,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221435
PNG
(US9303023, 132)
Show SMILES COc1cc(OC)nc(OCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1
Show InChI InChI=1S/C22H22N6O5/c1-14-5-4-6-15(9-14)20-19(23-13-33-20)21(29)25-16-11-24-28(12-16)7-8-32-22-26-17(30-2)10-18(27-22)31-3/h4-6,9-13H,7-8H2,1-3H3,(H,25,29)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221347
PNG
(US9303023, 66)
Show SMILES COc1ccc2[nH]cc(CCn3cnc(NC(=O)c4ncoc4-c4cccc(C)c4)c3)c2c1
Show InChI InChI=1S/C25H23N5O3/c1-16-4-3-5-17(10-16)24-23(28-15-33-24)25(31)29-22-13-30(14-27-22)9-8-18-12-26-21-7-6-19(32-2)11-20(18)21/h3-7,10-15,26H,8-9H2,1-2H3,(H,29,31)
PDB

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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221370
PNG
(US9303023, 67)
Show SMILES COc1cc(OC)nc(CCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1
Show InChI InChI=1S/C23H24N6O4/c1-15-6-4-7-16(10-15)22-21(24-14-33-22)23(30)26-17-12-25-29(13-17)9-5-8-18-27-19(31-2)11-20(28-18)32-3/h4,6-7,10-14H,5,8-9H2,1-3H3,(H,26,30)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221313
PNG
(US9303023, 12)
Show SMILES COc1cc2ccn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2cc1OC
Show InChI InChI=1S/C26H25N5O4/c1-17-5-4-6-19(11-17)25-24(27-16-35-25)26(32)29-20-14-28-31(15-20)10-9-30-8-7-18-12-22(33-2)23(34-3)13-21(18)30/h4-8,11-16H,9-10H2,1-3H3,(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221404
PNG
(US9303023, 101)
Show SMILES COc1cc2n(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)ccc2cn1
Show InChI InChI=1S/C24H22N6O3/c1-16-4-3-5-17(10-16)23-22(26-15-33-23)24(31)28-19-13-27-30(14-19)9-8-29-7-6-18-12-25-21(32-2)11-20(18)29/h3-7,10-15H,8-9H2,1-2H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221310
PNG
(US9303023, 9)
Show SMILES COc1cc(OC)nc(OCCn2cc(NC(=O)c3ncoc3-c3ccccc3)cn2)n1
Show InChI InChI=1S/C21H20N6O5/c1-29-16-10-17(30-2)26-21(25-16)31-9-8-27-12-15(11-23-27)24-20(28)18-19(32-13-22-18)14-6-4-3-5-7-14/h3-7,10-13H,8-9H2,1-2H3,(H,24,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221432
PNG
(US9303023, 129)
Show SMILES COc1cc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)nc(OC)n1
Show InChI InChI=1S/C22H23N7O4/c1-14-5-4-6-15(9-14)20-19(24-13-33-20)21(30)26-16-11-25-29(12-16)8-7-23-17-10-18(31-2)28-22(27-17)32-3/h4-6,9-13H,7-8H2,1-3H3,(H,26,30)(H,23,27,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221331
PNG
(US9303023, 30)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncsc4-c4cccc(C)c4)cn3)c2c1
Show InChI InChI=1S/C25H23N5O2S/c1-16-4-3-5-17(10-16)24-23(27-15-33-24)25(31)29-19-13-28-30(14-19)9-8-18-12-26-22-7-6-20(32-2)11-21(18)22/h3-7,10-15,26H,8-9H2,1-2H3,(H,29,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221329
PNG
(US9303023, 28)
Show SMILES COc1ccc(cc1)-c1ocnc1C(=O)Nc1cnn(CCc2c[nH]c3ccc(OC)cc23)c1
Show InChI InChI=1S/C25H23N5O4/c1-32-19-5-3-16(4-6-19)24-23(27-15-34-24)25(31)29-18-13-28-30(14-18)10-9-17-12-26-22-8-7-20(33-2)11-21(17)22/h3-8,11-15,26H,9-10H2,1-2H3,(H,29,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221411
PNG
(US9303023, 108)
Show SMILES COc1cc2n(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)ccc2cc1Cl
Show InChI InChI=1S/C25H22ClN5O3/c1-16-4-3-5-18(10-16)24-23(27-15-34-24)25(32)29-19-13-28-31(14-19)9-8-30-7-6-17-11-20(26)22(33-2)12-21(17)30/h3-7,10-15H,8-9H2,1-2H3,(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221357
PNG
(US9303023, 53)
Show SMILES COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3ccccc3F)cn2)n1
Show InChI InChI=1S/C21H20FN7O4/c1-31-16-9-17(32-2)28-21(27-16)23-7-8-29-11-13(10-25-29)26-20(30)18-19(33-12-24-18)14-5-3-4-6-15(14)22/h3-6,9-12H,7-8H2,1-2H3,(H,26,30)(H,23,27,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221434
PNG
(US9303023, 131)
Show SMILES COc1ccnc(NCCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1
Show InChI InChI=1S/C22H23N7O3/c1-15-5-3-6-16(11-15)20-19(25-14-32-20)21(30)27-17-12-26-29(13-17)10-4-8-23-22-24-9-7-18(28-22)31-2/h3,5-7,9,11-14H,4,8,10H2,1-2H3,(H,27,30)(H,23,24,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221445
PNG
(US9303023, 142)
Show SMILES COc1ccc2ccn(CCCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1
Show InChI InChI=1S/C26H25N5O3/c1-18-5-3-6-20(13-18)25-24(27-17-34-25)26(32)29-21-15-28-31(16-21)11-4-10-30-12-9-19-7-8-22(33-2)14-23(19)30/h3,5-9,12-17H,4,10-11H2,1-2H3,(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221325
PNG
(US9303023, 24)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4ccc(C)c(C)c4)cn3)c2c1
Show InChI InChI=1S/C26H25N5O3/c1-16-4-5-18(10-17(16)2)25-24(28-15-34-25)26(32)30-20-13-29-31(14-20)9-8-19-12-27-23-7-6-21(33-3)11-22(19)23/h4-7,10-15,27H,8-9H2,1-3H3,(H,30,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221353
PNG
(US9303023, 49)
Show SMILES COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3ccc(C)c(C)c3)cn2)n1
Show InChI InChI=1S/C23H25N7O4/c1-14-5-6-16(9-15(14)2)21-20(25-13-34-21)22(31)27-17-11-26-30(12-17)8-7-24-23-28-18(32-3)10-19(29-23)33-4/h5-6,9-13H,7-8H2,1-4H3,(H,27,31)(H,24,28,29)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221311
PNG
(US9303023, 10)
Show SMILES COc1cc(OC)nc(OCCn2cc(NC(=O)c3ncoc3-c3cccc(F)c3)cn2)n1
Show InChI InChI=1S/C21H19FN6O5/c1-30-16-9-17(31-2)27-21(26-16)32-7-6-28-11-15(10-24-28)25-20(29)18-19(33-12-23-18)13-4-3-5-14(22)8-13/h3-5,8-12H,6-7H2,1-2H3,(H,25,29)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221349
PNG
(US9303023, 145)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4ccon4)cn3)c2c1
Show InChI InChI=1S/C21H18N6O4/c1-29-15-2-3-17-16(8-15)13(9-22-17)4-6-27-11-14(10-24-27)25-21(28)19-20(30-12-23-19)18-5-7-31-26-18/h2-3,5,7-12,22H,4,6H2,1H3,(H,25,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221433
PNG
(US9303023, 130)
Show SMILES COc1cc(OC)nc(NCCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1
Show InChI InChI=1S/C23H25N7O4/c1-15-6-4-7-16(10-15)21-20(25-14-34-21)22(31)27-17-12-26-30(13-17)9-5-8-24-23-28-18(32-2)11-19(29-23)33-3/h4,6-7,10-14H,5,8-9H2,1-3H3,(H,27,31)(H,24,28,29)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221405
PNG
(US9303023, 102)
Show SMILES COc1cc2ncn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2cc1OC
Show InChI InChI=1S/C25H24N6O4/c1-16-5-4-6-17(9-16)24-23(27-15-35-24)25(32)29-18-12-28-31(13-18)8-7-30-14-26-19-10-21(33-2)22(34-3)11-20(19)30/h4-6,9-15H,7-8H2,1-3H3,(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221395
PNG
(US9303023, 92)
Show SMILES COc1cc(OC)c2ccn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2n1
Show InChI InChI=1S/C25H24N6O4/c1-16-5-4-6-17(11-16)23-22(26-15-35-23)25(32)28-18-13-27-31(14-18)10-9-30-8-7-19-20(33-2)12-21(34-3)29-24(19)30/h4-8,11-15H,9-10H2,1-3H3,(H,28,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221379
PNG
(US9303023, 76)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2cnc3ccccc23)c1
Show InChI InChI=1S/C23H20N6O2/c1-16-5-4-6-17(11-16)22-21(25-15-31-22)23(30)27-18-12-26-29(13-18)10-9-28-14-24-19-7-2-3-8-20(19)28/h2-8,11-15H,9-10H2,1H3,(H,27,30)
PDB

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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221343
PNG
(US9303023, 42)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncsc4-c4ccccc4)cn3)c2c1
Show InChI InChI=1S/C24H21N5O2S/c1-31-19-7-8-21-20(11-19)17(12-25-21)9-10-29-14-18(13-27-29)28-24(30)22-23(32-15-26-22)16-5-3-2-4-6-16/h2-8,11-15,25H,9-10H2,1H3,(H,28,30)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221377
PNG
(US9303023, 74)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2ccc3ccc(F)cc23)c1
Show InChI InChI=1S/C24H20FN5O2/c1-16-3-2-4-18(11-16)23-22(26-15-32-23)24(31)28-20-13-27-30(14-20)10-9-29-8-7-17-5-6-19(25)12-21(17)29/h2-8,11-15H,9-10H2,1H3,(H,28,31)
PDB

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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221341
PNG
(US9303023, 40)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(c4)-c4ccccc4)cn3)c2c1
Show InChI InChI=1S/C30H25N5O3/c1-37-25-10-11-27-26(15-25)23(16-31-27)12-13-35-18-24(17-33-35)34-30(36)28-29(38-19-32-28)22-9-5-8-21(14-22)20-6-3-2-4-7-20/h2-11,14-19,31H,12-13H2,1H3,(H,34,36)
PDB

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n/an/a 73n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221430
PNG
(US9303023, 127)
Show SMILES COc1cc(OC)nc(NCCn2cnc(NC(=O)c3ncoc3-c3cccc(C)c3)c2)n1
Show InChI InChI=1S/C22H23N7O4/c1-14-5-4-6-15(9-14)20-19(25-13-33-20)21(30)26-16-11-29(12-24-16)8-7-23-22-27-17(31-2)10-18(28-22)32-3/h4-6,9-13H,7-8H2,1-3H3,(H,26,30)(H,23,27,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221423
PNG
(US9303023, 120)
Show SMILES COc1ccnc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1
Show InChI InChI=1S/C21H21N7O3/c1-14-4-3-5-15(10-14)19-18(24-13-31-19)20(29)26-16-11-25-28(12-16)9-8-23-21-22-7-6-17(27-21)30-2/h3-7,10-13H,8-9H2,1-2H3,(H,26,29)(H,22,23,27)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221409
PNG
(US9303023, 106)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2ccc3cc(Cl)c(Cl)cc23)c1
Show InChI InChI=1S/C24H19Cl2N5O2/c1-15-3-2-4-17(9-15)23-22(27-14-33-23)24(32)29-18-12-28-31(13-18)8-7-30-6-5-16-10-19(25)20(26)11-21(16)30/h2-6,9-14H,7-8H2,1H3,(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221371
PNG
(US9303023, 68)
Show SMILES CCOc1cc(OC)nc(CCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1
Show InChI InChI=1S/C24H26N6O4/c1-4-33-21-12-20(32-3)28-19(29-21)9-6-10-30-14-18(13-26-30)27-24(31)22-23(34-15-25-22)17-8-5-7-16(2)11-17/h5,7-8,11-15H,4,6,9-10H2,1-3H3,(H,27,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221375
PNG
(US9303023, 72)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2ccc3ccccc23)c1
Show InChI InChI=1S/C24H21N5O2/c1-17-5-4-7-19(13-17)23-22(25-16-31-23)24(30)27-20-14-26-29(15-20)12-11-28-10-9-18-6-2-3-8-21(18)28/h2-10,13-16H,11-12H2,1H3,(H,27,30)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221383
PNG
(US9303023, 80)
Show SMILES COc1nc(OC)c2ccn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2n1
Show InChI InChI=1S/C24H23N7O4/c1-15-5-4-6-16(11-15)20-19(25-14-35-20)22(32)27-17-12-26-31(13-17)10-9-30-8-7-18-21(30)28-24(34-3)29-23(18)33-2/h4-8,11-14H,9-10H2,1-3H3,(H,27,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221366
PNG
(US9303023, 62)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCc2c[nH]c3ccc(F)cc23)c1
Show InChI InChI=1S/C24H20FN5O2/c1-15-3-2-4-16(9-15)23-22(27-14-32-23)24(31)29-19-12-28-30(13-19)8-7-17-11-26-21-6-5-18(25)10-20(17)21/h2-6,9-14,26H,7-8H2,1H3,(H,29,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221359
PNG
(US9303023, 55)
Show SMILES COc1ccc(cc1)-c1ocnc1C(=O)Nc1cnn(CCNc2nc(OC)cc(OC)n2)c1
Show InChI InChI=1S/C22H23N7O5/c1-31-16-6-4-14(5-7-16)20-19(24-13-34-20)21(30)26-15-11-25-29(12-15)9-8-23-22-27-17(32-2)10-18(28-22)33-3/h4-7,10-13H,8-9H2,1-3H3,(H,26,30)(H,23,27,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221394
PNG
(US9303023, 91)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2ccc3ccc(Cl)nc23)c1
Show InChI InChI=1S/C23H19ClN6O2/c1-15-3-2-4-17(11-15)21-20(25-14-32-21)23(31)27-18-12-26-30(13-18)10-9-29-8-7-16-5-6-19(24)28-22(16)29/h2-8,11-14H,9-10H2,1H3,(H,27,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221373
PNG
(US9303023, 70)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCSc2nc3ccccc3o2)c1
Show InChI InChI=1S/C23H19N5O3S/c1-15-5-4-6-16(11-15)21-20(24-14-30-21)22(29)26-17-12-25-28(13-17)9-10-32-23-27-18-7-2-3-8-19(18)31-23/h2-8,11-14H,9-10H2,1H3,(H,26,29)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221333
PNG
(US9303023, 32)
Show SMILES COc1cc(ccc1C)-c1ocnc1C(=O)Nc1cnn(CCn2ccc3cc(OC)c(OC)cc23)c1
Show InChI InChI=1S/C27H27N5O5/c1-17-5-6-19(12-22(17)34-2)26-25(28-16-37-26)27(33)30-20-14-29-32(15-20)10-9-31-8-7-18-11-23(35-3)24(36-4)13-21(18)31/h5-8,11-16H,9-10H2,1-4H3,(H,30,33)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221369
PNG
(US9303023, 65)
Show SMILES COc1cccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c12
Show InChI InChI=1S/C25H23N5O3/c1-16-5-3-6-17(11-16)24-23(27-15-33-24)25(31)29-19-13-28-30(14-19)10-9-18-12-26-20-7-4-8-21(32-2)22(18)20/h3-8,11-15,26H,9-10H2,1-2H3,(H,29,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221358
PNG
(US9303023, 54)
Show SMILES COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3ccccc3)cn2)n1
Show InChI InChI=1S/C21H21N7O4/c1-30-16-10-17(31-2)27-21(26-16)22-8-9-28-12-15(11-24-28)25-20(29)18-19(32-13-23-18)14-6-4-3-5-7-14/h3-7,10-13H,8-9H2,1-2H3,(H,25,29)(H,22,26,27)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221420
PNG
(US9303023, 117)
Show SMILES Cc1cccc(c1)-c1scnc1C(=O)Nc1cnn(CCNc2cnc3ccccc3n2)c1
Show InChI InChI=1S/C24H21N7OS/c1-16-5-4-6-17(11-16)23-22(27-15-33-23)24(32)29-18-12-28-31(14-18)10-9-25-21-13-26-19-7-2-3-8-20(19)30-21/h2-8,11-15H,9-10H2,1H3,(H,25,30)(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221414
PNG
(US9303023, 111)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCNc2ncc3ccccc3n2)c1
Show InChI InChI=1S/C24H21N7O2/c1-16-5-4-7-17(11-16)22-21(27-15-33-22)23(32)29-19-13-28-31(14-19)10-9-25-24-26-12-18-6-2-3-8-20(18)30-24/h2-8,11-15H,9-10H2,1H3,(H,29,32)(H,25,26,30)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221319
PNG
(US9303023, 18)
Show SMILES COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(c3)N3CCOCC3)cn2)n1
Show InChI InChI=1S/C25H28N8O5/c1-35-20-13-21(36-2)31-25(30-20)26-6-7-33-15-18(14-28-33)29-24(34)22-23(38-16-27-22)17-4-3-5-19(12-17)32-8-10-37-11-9-32/h3-5,12-16H,6-11H2,1-2H3,(H,29,34)(H,26,30,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221391
PNG
(US9303023, 88)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2ccc3cccnc23)c1
Show InChI InChI=1S/C23H20N6O2/c1-16-4-2-5-18(12-16)21-20(25-15-31-21)23(30)27-19-13-26-29(14-19)11-10-28-9-7-17-6-3-8-24-22(17)28/h2-9,12-15H,10-11H2,1H3,(H,27,30)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221334
PNG
(US9303023, 33)
Show SMILES COc1cc2ccn(CCn3cc(NC(=O)c4ncoc4-c4cccc(F)c4)cn3)c2cc1OC
Show InChI InChI=1S/C25H22FN5O4/c1-33-21-11-16-6-7-30(20(16)12-22(21)34-2)8-9-31-14-19(13-28-31)29-25(32)23-24(35-15-27-23)17-4-3-5-18(26)10-17/h3-7,10-15H,8-9H2,1-2H3,(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221326
PNG
(US9303023, 25)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4ccc(C)c(OC)c4)cn3)c2c1
Show InChI InChI=1S/C26H25N5O4/c1-16-4-5-17(10-23(16)34-3)25-24(28-15-35-25)26(32)30-19-13-29-31(14-19)9-8-18-12-27-22-7-6-20(33-2)11-21(18)22/h4-7,10-15,27H,8-9H2,1-3H3,(H,30,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221312
PNG
(US9303023, 11)
Show SMILES COc1cc(OC)nc(OCCn2cc(NC(=O)c3ncoc3-c3cccc(c3)N(C)C)cn2)n1
Show InChI InChI=1S/C23H25N7O5/c1-29(2)17-7-5-6-15(10-17)21-20(24-14-35-21)22(31)26-16-12-25-30(13-16)8-9-34-23-27-18(32-3)11-19(28-23)33-4/h5-7,10-14H,8-9H2,1-4H3,(H,26,31)
PDB

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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221305
PNG
(US9303023, 4)
Show SMILES Cc1nc2ccccc2n1CCn1cc(NC(=O)c2ncoc2-c2cccc(C)c2)cn1
Show InChI InChI=1S/C24H22N6O2/c1-16-6-5-7-18(12-16)23-22(25-15-32-23)24(31)28-19-13-26-29(14-19)10-11-30-17(2)27-20-8-3-4-9-21(20)30/h3-9,12-15H,10-11H2,1-2H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221427
PNG
(US9303023, 124)
Show SMILES COc1nc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)nc(OC)c1C
Show InChI InChI=1S/C23H25N7O4/c1-14-6-5-7-16(10-14)19-18(25-13-34-19)20(31)27-17-11-26-30(12-17)9-8-24-23-28-21(32-3)15(2)22(29-23)33-4/h5-7,10-13H,8-9H2,1-4H3,(H,27,31)(H,24,28,29)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221378
PNG
(US9303023, 75)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2ccc3cccc(F)c23)c1
Show InChI InChI=1S/C24H20FN5O2/c1-16-4-2-6-18(12-16)23-21(26-15-32-23)24(31)28-19-13-27-30(14-19)11-10-29-9-8-17-5-3-7-20(25)22(17)29/h2-9,12-15H,10-11H2,1H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221399
PNG
(US9303023, 96)
Show SMILES Cc1nn(CCn2ccc3ccccc23)c(C)c1NC(=O)c1ncoc1-c1cccc(C)c1
Show InChI InChI=1S/C26H25N5O2/c1-17-7-6-9-21(15-17)25-24(27-16-33-25)26(32)28-23-18(2)29-31(19(23)3)14-13-30-12-11-20-8-4-5-10-22(20)30/h4-12,15-16H,13-14H2,1-3H3,(H,28,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221318
PNG
(US9303023, 17)
Show SMILES COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(c3)N3CCCC3)cn2)n1
Show InChI InChI=1S/C25H28N8O4/c1-35-20-13-21(36-2)31-25(30-20)26-8-11-33-15-18(14-28-33)29-24(34)22-23(37-16-27-22)17-6-5-7-19(12-17)32-9-3-4-10-32/h5-7,12-16H,3-4,8-11H2,1-2H3,(H,29,34)(H,26,30,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221380
PNG
(US9303023, 77)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2ccc3cc(C)ccc23)c1
Show InChI InChI=1S/C25H23N5O2/c1-17-4-3-5-20(13-17)24-23(26-16-32-24)25(31)28-21-14-27-30(15-21)11-10-29-9-8-19-12-18(2)6-7-22(19)29/h3-9,12-16H,10-11H2,1-2H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221402
PNG
(US9303023, 99)
Show SMILES COc1cc2n(CCn3nc(C)c(NC(=O)c4ncoc4-c4cccc(C)c4)c3C)ccc2cn1
Show InChI InChI=1S/C26H26N6O3/c1-16-6-5-7-19(12-16)25-24(28-15-35-25)26(33)29-23-17(2)30-32(18(23)3)11-10-31-9-8-20-14-27-22(34-4)13-21(20)31/h5-9,12-15H,10-11H2,1-4H3,(H,29,33)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221345
PNG
(US9303023, 44)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncsc4-c4ccc(C)c(C)c4)cn3)c2c1
Show InChI InChI=1S/C26H25N5O2S/c1-16-4-5-18(10-17(16)2)25-24(28-15-34-25)26(32)30-20-13-29-31(14-20)9-8-19-12-27-23-7-6-21(33-3)11-22(19)23/h4-7,10-15,27H,8-9H2,1-3H3,(H,30,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221438
PNG
(US9303023, 135)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCOc2ncc3ccccc3n2)c1
Show InChI InChI=1S/C24H20N6O3/c1-16-5-4-7-17(11-16)22-21(26-15-33-22)23(31)28-19-13-27-30(14-19)9-10-32-24-25-12-18-6-2-3-8-20(18)29-24/h2-8,11-15H,9-10H2,1H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221396
PNG
(US9303023, 93)
Show SMILES COc1cc2ccn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2cn1
Show InChI InChI=1S/C24H22N6O3/c1-16-4-3-5-18(10-16)23-22(26-15-33-23)24(31)28-19-12-27-30(14-19)9-8-29-7-6-17-11-21(32-2)25-13-20(17)29/h3-7,10-15H,8-9H2,1-2H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221336
PNG
(US9303023, 35)
Show SMILES COc1ccc(cc1)-c1ocnc1C(=O)Nc1cnn(CCn2ccc3cc(OC)c(OC)cc23)c1
Show InChI InChI=1S/C26H25N5O5/c1-33-20-6-4-17(5-7-20)25-24(27-16-36-25)26(32)29-19-14-28-31(15-19)11-10-30-9-8-18-12-22(34-2)23(35-3)13-21(18)30/h4-9,12-16H,10-11H2,1-3H3,(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221416
PNG
(US9303023, 113)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCNc2nc3ccccc3o2)c1
Show InChI InChI=1S/C23H20N6O3/c1-15-5-4-6-16(11-15)21-20(25-14-31-21)22(30)27-17-12-26-29(13-17)10-9-24-23-28-18-7-2-3-8-19(18)32-23/h2-8,11-14H,9-10H2,1H3,(H,24,28)(H,27,30)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221346
PNG
(US9303023, 45)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncsc4-c4ccc(OC)nc4)cn3)c2c1
Show InChI InChI=1S/C24H22N6O3S/c1-32-18-4-5-20-19(9-18)15(10-25-20)7-8-30-13-17(12-28-30)29-24(31)22-23(34-14-27-22)16-3-6-21(33-2)26-11-16/h3-6,9-14,25H,7-8H2,1-2H3,(H,29,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221362
PNG
(US9303023, 58)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C24H21N5O2/c1-16-5-4-6-17(11-16)23-22(26-15-31-23)24(30)28-19-13-27-29(14-19)10-9-18-12-25-21-8-3-2-7-20(18)21/h2-8,11-15,25H,9-10H2,1H3,(H,28,30)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221419
PNG
(US9303023, 116)
Show SMILES Cc1cccc(c1)-c1scnc1C(=O)Nc1cnn(CCNc2nc3ccccc3o2)c1
Show InChI InChI=1S/C23H20N6O2S/c1-15-5-4-6-16(11-15)21-20(25-14-32-21)22(30)27-17-12-26-29(13-17)10-9-24-23-28-18-7-2-3-8-19(18)31-23/h2-8,11-14H,9-10H2,1H3,(H,24,28)(H,27,30)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221354
PNG
(US9303023, 50)
Show SMILES COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3ccc(C)c(OC)c3)cn2)n1
Show InChI InChI=1S/C23H25N7O5/c1-14-5-6-15(9-17(14)32-2)21-20(25-13-35-21)22(31)27-16-11-26-30(12-16)8-7-24-23-28-18(33-3)10-19(29-23)34-4/h5-6,9-13H,7-8H2,1-4H3,(H,27,31)(H,24,28,29)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221323
PNG
(US9303023, 22)
Show SMILES COc1ccc2CCN(CCCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1
Show InChI InChI=1S/C26H27N5O3/c1-18-5-3-6-20(13-18)25-24(27-17-34-25)26(32)29-21-15-28-31(16-21)11-4-10-30-12-9-19-7-8-22(33-2)14-23(19)30/h3,5-8,13-17H,4,9-12H2,1-2H3,(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221316
PNG
(US9303023, 15)
Show SMILES COc1ccnc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)c1
Show InChI InChI=1S/C22H22N6O3/c1-15-4-3-5-16(10-15)21-20(25-14-31-21)22(29)27-17-12-26-28(13-17)9-8-24-19-11-18(30-2)6-7-23-19/h3-7,10-14H,8-9H2,1-2H3,(H,23,24)(H,27,29)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221426
PNG
(US9303023, 123)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCNc2nc(C)cc(C)n2)c1
Show InChI InChI=1S/C22H23N7O2/c1-14-5-4-6-17(9-14)20-19(24-13-31-20)21(30)28-18-11-25-29(12-18)8-7-23-22-26-15(2)10-16(3)27-22/h4-6,9-13H,7-8H2,1-3H3,(H,28,30)(H,23,26,27)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221361
PNG
(US9303023, 57)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCc2cn(C)c3ccccc23)c1
Show InChI InChI=1S/C25H23N5O2/c1-17-6-5-7-18(12-17)24-23(26-16-32-24)25(31)28-20-13-27-30(15-20)11-10-19-14-29(2)22-9-4-3-8-21(19)22/h3-9,12-16H,10-11H2,1-2H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221429
PNG
(US9303023, 126)
Show SMILES COc1cc(OC)nc(N[C@@H](C)Cn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1
Show InChI InChI=1S/C23H25N7O4/c1-14-6-5-7-16(8-14)21-20(24-13-34-21)22(31)27-17-10-25-30(12-17)11-15(2)26-23-28-18(32-3)9-19(29-23)33-4/h5-10,12-13,15H,11H2,1-4H3,(H,27,31)(H,26,28,29)/t15-/m0/s1
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221418
PNG
(US9303023, 115)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCNc2cnc3ccccc3n2)c1
Show InChI InChI=1S/C24H21N7O2/c1-16-5-4-6-17(11-16)23-22(27-15-33-23)24(32)29-18-12-28-31(14-18)10-9-25-21-13-26-19-7-2-3-8-20(19)30-21/h2-8,11-15H,9-10H2,1H3,(H,25,30)(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221337
PNG
(US9303023, 36)
Show SMILES COc1cc2ccn(CCn3cc(NC(=O)c4ncoc4-c4ccccc4F)cn3)c2cc1OC
Show InChI InChI=1S/C25H22FN5O4/c1-33-21-11-16-7-8-30(20(16)12-22(21)34-2)9-10-31-14-17(13-28-31)29-25(32)23-24(35-15-27-23)18-5-3-4-6-19(18)26/h3-8,11-15H,9-10H2,1-2H3,(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221406
PNG
(US9303023, 103)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2ccc3ncccc23)c1
Show InChI InChI=1S/C23H20N6O2/c1-16-4-2-5-17(12-16)22-21(25-15-31-22)23(30)27-18-13-26-29(14-18)11-10-28-9-7-19-20(28)6-3-8-24-19/h2-9,12-15H,10-11H2,1H3,(H,27,30)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221444
PNG
(US9303023, 141)
Show SMILES COc1cc(OC)nc(n1)N1CCCC1Cn1cc(NC(=O)c2ncoc2-c2cccc(C)c2)cn1
Show InChI InChI=1S/C25H27N7O4/c1-16-6-4-7-17(10-16)23-22(26-15-36-23)24(33)28-18-12-27-31(13-18)14-19-8-5-9-32(19)25-29-20(34-2)11-21(30-25)35-3/h4,6-7,10-13,15,19H,5,8-9,14H2,1-3H3,(H,28,33)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221424
PNG
(US9303023, 121)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cn(CCNc2ncc3ccccc3n2)cn1
Show InChI InChI=1S/C24H21N7O2/c1-16-5-4-7-17(11-16)22-21(28-15-33-22)23(32)30-20-13-31(14-27-20)10-9-25-24-26-12-18-6-2-3-8-19(18)29-24/h2-8,11-15H,9-10H2,1H3,(H,30,32)(H,25,26,29)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221335
PNG
(US9303023, 34)
Show SMILES COc1cc2ccn(CCn3cc(NC(=O)c4ncoc4-c4ccccc4)cn3)c2cc1OC
Show InChI InChI=1S/C25H23N5O4/c1-32-21-12-18-8-9-29(20(18)13-22(21)33-2)10-11-30-15-19(14-27-30)28-25(31)23-24(34-16-26-23)17-6-4-3-5-7-17/h3-9,12-16H,10-11H2,1-2H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221355
PNG
(US9303023, 51)
Show SMILES COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(c3)C#N)cn2)n1
Show InChI InChI=1S/C22H20N8O4/c1-32-17-9-18(33-2)29-22(28-17)24-6-7-30-12-16(11-26-30)27-21(31)19-20(34-13-25-19)15-5-3-4-14(8-15)10-23/h3-5,8-9,11-13H,6-7H2,1-2H3,(H,27,31)(H,24,28,29)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221428
PNG
(US9303023, 125)
Show SMILES COc1cc(OC)nc(N[C@H](C)Cn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1
Show InChI InChI=1S/C23H25N7O4/c1-14-6-5-7-16(8-14)21-20(24-13-34-21)22(31)27-17-10-25-30(12-17)11-15(2)26-23-28-18(32-3)9-19(29-23)33-4/h5-10,12-13,15H,11H2,1-4H3,(H,27,31)(H,26,28,29)/t15-/m1/s1
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221317
PNG
(US9303023, 16)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCN2CCc3ccccc23)c1
Show InChI InChI=1S/C24H23N5O2/c1-17-5-4-7-19(13-17)23-22(25-16-31-23)24(30)27-20-14-26-29(15-20)12-11-28-10-9-18-6-2-3-8-21(18)28/h2-8,13-16H,9-12H2,1H3,(H,27,30)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221388
PNG
(US9303023, 85)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2ccc3cccc(C)c23)c1
Show InChI InChI=1S/C25H23N5O2/c1-17-5-3-8-20(13-17)24-22(26-16-32-24)25(31)28-21-14-27-30(15-21)12-11-29-10-9-19-7-4-6-18(2)23(19)29/h3-10,13-16H,11-12H2,1-2H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221315
PNG
(US9303023, 14)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCNc2cc(F)ccn2)c1
Show InChI InChI=1S/C21H19FN6O2/c1-14-3-2-4-15(9-14)20-19(25-13-30-20)21(29)27-17-11-26-28(12-17)8-7-24-18-10-16(22)5-6-23-18/h2-6,9-13H,7-8H2,1H3,(H,23,24)(H,27,29)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221320
PNG
(US9303023, 19)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCCn2ccc3ccccc23)c1
Show InChI InChI=1S/C25H23N5O2/c1-18-6-4-8-20(14-18)24-23(26-17-32-24)25(31)28-21-15-27-30(16-21)12-5-11-29-13-10-19-7-2-3-9-22(19)29/h2-4,6-10,13-17H,5,11-12H2,1H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221308
PNG
(US9303023, 7)
Show SMILES COc1cccc(CCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)c1
Show InChI InChI=1S/C23H22N4O3/c1-16-5-3-7-18(11-16)22-21(24-15-30-22)23(28)26-19-13-25-27(14-19)10-9-17-6-4-8-20(12-17)29-2/h3-8,11-15H,9-10H2,1-2H3,(H,26,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221372
PNG
(US9303023, 69)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCOc2ccc3OCOc3c2)c1
Show InChI InChI=1S/C23H20N4O5/c1-15-3-2-4-16(9-15)22-21(24-13-30-22)23(28)26-17-11-25-27(12-17)7-8-29-18-5-6-19-20(10-18)32-14-31-19/h2-6,9-13H,7-8,14H2,1H3,(H,26,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221400
PNG
(US9303023, 97)
Show SMILES Cc1nn(CCn2cnc3ccccc23)c(C)c1NC(=O)c1ncoc1-c1cccc(C)c1
Show InChI InChI=1S/C25H24N6O2/c1-16-7-6-8-19(13-16)24-23(27-15-33-24)25(32)28-22-17(2)29-31(18(22)3)12-11-30-14-26-20-9-4-5-10-21(20)30/h4-10,13-15H,11-12H2,1-3H3,(H,28,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221306
PNG
(US9303023, 5)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCNc2ccc(F)cn2)c1
Show InChI InChI=1S/C21H19FN6O2/c1-14-3-2-4-15(9-14)20-19(25-13-30-20)21(29)27-17-11-26-28(12-17)8-7-23-18-6-5-16(22)10-24-18/h2-6,9-13H,7-8H2,1H3,(H,23,24)(H,27,29)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221403
PNG
(US9303023, 100)
Show SMILES COc1cc2ccn(CCn3nc(C)c(NC(=O)c4ncoc4-c4cccc(C)c4)c3C)c2cc1OC
Show InChI InChI=1S/C28H29N5O4/c1-17-7-6-8-21(13-17)27-26(29-16-37-27)28(34)30-25-18(2)31-33(19(25)3)12-11-32-10-9-20-14-23(35-4)24(36-5)15-22(20)32/h6-10,13-16H,11-12H2,1-5H3,(H,30,34)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221389
PNG
(US9303023, 86)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCOc2cc(C)cc(C)n2)c1
Show InChI InChI=1S/C23H23N5O3/c1-15-5-4-6-18(10-15)22-21(24-14-31-22)23(29)27-19-12-25-28(13-19)7-8-30-20-11-16(2)9-17(3)26-20/h4-6,9-14H,7-8H2,1-3H3,(H,27,29)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221398
PNG
(US9303023, 95)
Show SMILES COc1ncnc2ncn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c12
Show InChI InChI=1S/C22H20N8O3/c1-14-4-3-5-15(8-14)19-17(26-13-33-19)21(31)28-16-9-27-30(10-16)7-6-29-12-25-20-18(29)22(32-2)24-11-23-20/h3-5,8-13H,6-7H2,1-2H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221314
PNG
(US9303023, 13)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCCN2CCc3ccccc23)c1
Show InChI InChI=1S/C25H25N5O2/c1-18-6-4-8-20(14-18)24-23(26-17-32-24)25(31)28-21-15-27-30(16-21)12-5-11-29-13-10-19-7-2-3-9-22(19)29/h2-4,6-9,14-17H,5,10-13H2,1H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221410
PNG
(US9303023, 107)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2ccc3cc(Cl)ccc23)c1
Show InChI InChI=1S/C24H20ClN5O2/c1-16-3-2-4-18(11-16)23-22(26-15-32-23)24(31)28-20-13-27-30(14-20)10-9-29-8-7-17-12-19(25)5-6-21(17)29/h2-8,11-15H,9-10H2,1H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221309
PNG
(US9303023, 8)
Show SMILES COc1cccc(OCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)c1
Show InChI InChI=1S/C23H22N4O4/c1-16-5-3-6-17(11-16)22-21(24-15-31-22)23(28)26-18-13-25-27(14-18)9-10-30-20-8-4-7-19(12-20)29-2/h3-8,11-15H,9-10H2,1-2H3,(H,26,28)
PDB

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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221382
PNG
(US9303023, 79)
Show SMILES COc1ccnc2n(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)ccc12
Show InChI InChI=1S/C24H22N6O3/c1-16-4-3-5-17(12-16)22-21(26-15-33-22)24(31)28-18-13-27-30(14-18)11-10-29-9-7-19-20(32-2)6-8-25-23(19)29/h3-9,12-15H,10-11H2,1-2H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221342
PNG
(US9303023, 41)
Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4ccc(cc4)C(F)(F)F)cn3)c2c1
Show InChI InChI=1S/C25H20F3N5O3/c1-35-19-6-7-21-20(10-19)16(11-29-21)8-9-33-13-18(12-31-33)32-24(34)22-23(36-14-30-22)15-2-4-17(5-3-15)25(26,27)28/h2-7,10-14,29H,8-9H2,1H3,(H,32,34)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221350
PNG
(US9303023, 46)
Show SMILES Cc1nc2ccccc2n1CCn1cc(NC(=O)c2ncoc2-c2ccccc2)cn1
Show InChI InChI=1S/C23H20N6O2/c1-16-26-19-9-5-6-10-20(19)29(16)12-11-28-14-18(13-25-28)27-23(30)21-22(31-15-24-21)17-7-3-2-4-8-17/h2-10,13-15H,11-12H2,1H3,(H,27,30)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221439
PNG
(US9303023, 136)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCOc2cnc3ccccc3n2)c1
Show InChI InChI=1S/C24H20N6O3/c1-16-5-4-6-17(11-16)23-22(26-15-33-23)24(31)28-18-12-27-30(14-18)9-10-32-21-13-25-19-7-2-3-8-20(19)29-21/h2-8,11-15H,9-10H2,1H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221442
PNG
(US9303023, 139)
Show SMILES CCN(CCn1cc(NC(=O)c2ncoc2-c2cccc(C)c2)cn1)c1nc(OC)cc(OC)n1
Show InChI InChI=1S/C24H27N7O4/c1-5-30(24-28-19(33-3)12-20(29-24)34-4)9-10-31-14-18(13-26-31)27-23(32)21-22(35-15-25-21)17-8-6-7-16(2)11-17/h6-8,11-15H,5,9-10H2,1-4H3,(H,27,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221364
PNG
(US9303023, 60)
Show SMILES COc1ccc2c(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)cn(C)c2c1
Show InChI InChI=1S/C26H25N5O3/c1-17-5-4-6-18(11-17)25-24(27-16-34-25)26(32)29-20-13-28-31(15-20)10-9-19-14-30(2)23-12-21(33-3)7-8-22(19)23/h4-8,11-16H,9-10H2,1-3H3,(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221351
PNG
(US9303023, 47)
Show SMILES Cc1nc2ccccc2n1CCn1cc(NC(=O)c2ncoc2-c2ccc(C)c(C)c2)cn1
Show InChI InChI=1S/C25H24N6O2/c1-16-8-9-19(12-17(16)2)24-23(26-15-33-24)25(32)29-20-13-27-30(14-20)10-11-31-18(3)28-21-6-4-5-7-22(21)31/h4-9,12-15H,10-11H2,1-3H3,(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221401
PNG
(US9303023, 98)
Show SMILES COc1cc2ccn(CCn3nc(C)c(NC(=O)c4ncoc4-c4cccc(C)c4)c3C)c2cn1
Show InChI InChI=1S/C26H26N6O3/c1-16-6-5-7-20(12-16)25-24(28-15-35-25)26(33)29-23-17(2)30-32(18(23)3)11-10-31-9-8-19-13-22(34-4)27-14-21(19)31/h5-9,12-15H,10-11H2,1-4H3,(H,29,33)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221407
PNG
(US9303023, 104)
Show SMILES COc1ccc2n(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)ccc2c1
Show InChI InChI=1S/C25H23N5O3/c1-17-4-3-5-19(12-17)24-23(26-16-33-24)25(31)28-20-14-27-30(15-20)11-10-29-9-8-18-13-21(32-2)6-7-22(18)29/h3-9,12-16H,10-11H2,1-2H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221390
PNG
(US9303023, 87)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCOc2cccc(C)n2)c1
Show InChI InChI=1S/C22H21N5O3/c1-15-5-3-7-17(11-15)21-20(23-14-30-21)22(28)26-18-12-24-27(13-18)9-10-29-19-8-4-6-16(2)25-19/h3-8,11-14H,9-10H2,1-2H3,(H,26,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221412
PNG
(US9303023, 109)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2ccc(c2)-c2ccccc2)c1
Show InChI InChI=1S/C26H23N5O2/c1-19-6-5-9-21(14-19)25-24(27-18-33-25)26(32)29-23-15-28-31(17-23)13-12-30-11-10-22(16-30)20-7-3-2-4-8-20/h2-11,14-18H,12-13H2,1H3,(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221437
PNG
(US9303023, 134)
Show SMILES Cc1cnc(OCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)nc1
Show InChI InChI=1S/C21H20N6O3/c1-14-4-3-5-16(8-14)19-18(24-13-30-19)20(28)26-17-11-25-27(12-17)6-7-29-21-22-9-15(2)10-23-21/h3-5,8-13H,6-7H2,1-2H3,(H,26,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221321
PNG
(US9303023, 20)
Show SMILES COc1cnc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)nc1OC
Show InChI InChI=1S/C22H23N7O4/c1-14-5-4-6-15(9-14)19-18(25-13-33-19)20(30)27-16-10-26-29(12-16)8-7-23-22-24-11-17(31-2)21(28-22)32-3/h4-6,9-13H,7-8H2,1-3H3,(H,27,30)(H,23,24,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221446
PNG
(US9303023, 143)
Show SMILES COc1ccc2n(CCCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)ccc2c1
Show InChI InChI=1S/C26H25N5O3/c1-18-5-3-6-20(13-18)25-24(27-17-34-25)26(32)29-21-15-28-31(16-21)11-4-10-30-12-9-19-14-22(33-2)7-8-23(19)30/h3,5-9,12-17H,4,10-11H2,1-2H3,(H,29,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221443
PNG
(US9303023, 140)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCNc2nc3ccccc3n2C)c1
Show InChI InChI=1S/C24H23N7O2/c1-16-6-5-7-17(12-16)22-21(26-15-33-22)23(32)28-18-13-27-31(14-18)11-10-25-24-29-19-8-3-4-9-20(19)30(24)2/h3-9,12-15H,10-11H2,1-2H3,(H,25,29)(H,28,32)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221385
PNG
(US9303023, 82)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCOc2cccc(F)c2)c1
Show InChI InChI=1S/C22H19FN4O3/c1-15-4-2-5-16(10-15)21-20(24-14-30-21)22(28)26-18-12-25-27(13-18)8-9-29-19-7-3-6-17(23)11-19/h2-7,10-14H,8-9H2,1H3,(H,26,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221436
PNG
(US9303023, 133)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCOc2nc3ccccc3o2)c1
Show InChI InChI=1S/C23H19N5O4/c1-15-5-4-6-16(11-15)21-20(24-14-31-21)22(29)26-17-12-25-28(13-17)9-10-30-23-27-18-7-2-3-8-19(18)32-23/h2-8,11-14H,9-10H2,1H3,(H,26,29)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221374
PNG
(US9303023, 71)
Show SMILES Cc1nc2ccc(OCCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)cc2o1
Show InChI InChI=1S/C24H21N5O4/c1-15-4-3-5-17(10-15)23-22(25-14-32-23)24(30)28-18-12-26-29(13-18)8-9-31-19-6-7-20-21(11-19)33-16(2)27-20/h3-7,10-14H,8-9H2,1-2H3,(H,28,30)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221421
PNG
(US9303023, 118)
Show SMILES Cc1cnc(NCCn2cc(NC(=O)c3ncsc3-c3cccc(C)c3)cn2)nc1
Show InChI InChI=1S/C21H21N7OS/c1-14-4-3-5-16(8-14)19-18(25-13-30-19)20(29)27-17-11-26-28(12-17)7-6-22-21-23-9-15(2)10-24-21/h3-5,8-13H,6-7H2,1-2H3,(H,27,29)(H,22,23,24)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221441
PNG
(US9303023, 138)
Show SMILES Cc1nn(CCOc2nc3ccccc3o2)c(C)c1NC(=O)c1ncoc1-c1cccc(C)c1
Show InChI InChI=1S/C25H23N5O4/c1-15-7-6-8-18(13-15)23-22(26-14-33-23)24(31)28-21-16(2)29-30(17(21)3)11-12-32-25-27-19-9-4-5-10-20(19)34-25/h4-10,13-14H,11-12H2,1-3H3,(H,28,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221387
PNG
(US9303023, 84)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCOc2ccc(F)cc2)c1
Show InChI InChI=1S/C22H19FN4O3/c1-15-3-2-4-16(11-15)21-20(24-14-30-21)22(28)26-18-12-25-27(13-18)9-10-29-19-7-5-17(23)6-8-19/h2-8,11-14H,9-10H2,1H3,(H,26,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221302
PNG
(US9303023, 1)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCOc2ccccc2)c1
Show InChI InChI=1S/C22H20N4O3/c1-16-6-5-7-17(12-16)21-20(23-15-29-21)22(27)25-18-13-24-26(14-18)10-11-28-19-8-3-2-4-9-19/h2-9,12-15H,10-11H2,1H3,(H,25,27)
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n/an/a 984n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221440
PNG
(US9303023, 137)
Show SMILES COc1cc(OC)nc(OCCn2nc(C)c(NC(=O)c3ncoc3-c3cccc(C)c3)c2C)n1
Show InChI InChI=1S/C24H26N6O5/c1-14-7-6-8-17(11-14)22-21(25-13-35-22)23(31)28-20-15(2)29-30(16(20)3)9-10-34-24-26-18(32-4)12-19(27-24)33-5/h6-8,11-13H,9-10H2,1-5H3,(H,28,31)
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n/an/a 1.02E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221307
PNG
(US9303023, 6)
Show SMILES Cc1ccc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)nc1
Show InChI InChI=1S/C22H22N6O2/c1-15-4-3-5-17(10-15)21-20(25-14-30-21)22(29)27-18-12-26-28(13-18)9-8-23-19-7-6-16(2)11-24-19/h3-7,10-14H,8-9H2,1-2H3,(H,23,24)(H,27,29)
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n/an/a 1.04E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221397
PNG
(US9303023, 94)
Show SMILES COc1ncnc2n(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)cnc12
Show InChI InChI=1S/C22H20N8O3/c1-14-4-3-5-15(8-14)19-17(26-13-33-19)21(31)28-16-9-27-30(10-16)7-6-29-12-25-18-20(29)23-11-24-22(18)32-2/h3-5,8-13H,6-7H2,1-2H3,(H,28,31)
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n/an/a 1.08E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221431
PNG
(US9303023, 128)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCNc2ncc(Br)cn2)c1
Show InChI InChI=1S/C20H18BrN7O2/c1-13-3-2-4-14(7-13)18-17(25-12-30-18)19(29)27-16-10-26-28(11-16)6-5-22-20-23-8-15(21)9-24-20/h2-4,7-12H,5-6H2,1H3,(H,27,29)(H,22,23,24)
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n/an/a 1.16E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221422
PNG
(US9303023, 119)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCNc2ncccn2)c1
Show InChI InChI=1S/C20H19N7O2/c1-14-4-2-5-15(10-14)18-17(24-13-29-18)19(28)26-16-11-25-27(12-16)9-8-23-20-21-6-3-7-22-20/h2-7,10-13H,8-9H2,1H3,(H,26,28)(H,21,22,23)
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n/an/a 1.16E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221304
PNG
(US9303023, 3)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCc2ccccc2)c1
Show InChI InChI=1S/C22H20N4O2/c1-16-6-5-9-18(12-16)21-20(23-15-28-21)22(27)25-19-13-24-26(14-19)11-10-17-7-3-2-4-8-17/h2-9,12-15H,10-11H2,1H3,(H,25,27)
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n/an/a 1.28E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221363
PNG
(US9303023, 59)
Show SMILES COc1ccc2c(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c[nH]c2c1
Show InChI InChI=1S/C25H23N5O3/c1-16-4-3-5-17(10-16)24-23(27-15-33-24)25(31)29-19-13-28-30(14-19)9-8-18-12-26-22-11-20(32-2)6-7-21(18)22/h3-7,10-15,26H,8-9H2,1-2H3,(H,29,31)
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n/an/a 1.66E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221303
PNG
(US9303023, 2)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCc2cccc(F)c2)c1
Show InChI InChI=1S/C22H19FN4O2/c1-15-4-2-6-17(10-15)21-20(24-14-29-21)22(28)26-19-12-25-27(13-19)9-8-16-5-3-7-18(23)11-16/h2-7,10-14H,8-9H2,1H3,(H,26,28)
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n/an/a 1.78E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221322
PNG
(US9303023, 21)
Show SMILES COc1ccc2N(CCCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)CCc2c1
Show InChI InChI=1S/C26H27N5O3/c1-18-5-3-6-20(13-18)25-24(27-17-34-25)26(32)29-21-15-28-31(16-21)11-4-10-30-12-9-19-14-22(33-2)7-8-23(19)30/h3,5-8,13-17H,4,9-12H2,1-2H3,(H,29,32)
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n/an/a 1.83E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221384
PNG
(US9303023, 81)
Show SMILES Cc1ccc(OCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)nc1
Show InChI InChI=1S/C22H21N5O3/c1-15-4-3-5-17(10-15)21-20(24-14-30-21)22(28)26-18-12-25-27(13-18)8-9-29-19-7-6-16(2)11-23-19/h3-7,10-14H,8-9H2,1-2H3,(H,26,28)
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n/an/a 1.85E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221376
PNG
(US9303023, 73)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCOc2cc(n(C)n2)C(F)(F)F)c1
Show InChI InChI=1S/C21H19F3N6O3/c1-13-4-3-5-14(8-13)19-18(25-12-33-19)20(31)27-15-10-26-30(11-15)6-7-32-17-9-16(21(22,23)24)29(2)28-17/h3-5,8-12H,6-7H2,1-2H3,(H,27,31)
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n/an/a 1.99E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221393
PNG
(US9303023, 90)
Show SMILES Cc1ccnc(OCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)c1
Show InChI InChI=1S/C22H21N5O3/c1-15-4-3-5-17(10-15)21-20(24-14-30-21)22(28)26-18-12-25-27(13-18)8-9-29-19-11-16(2)6-7-23-19/h3-7,10-14H,8-9H2,1-2H3,(H,26,28)
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n/an/a 2.02E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221392
PNG
(US9303023, 89)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCOc2ccc(F)cn2)c1
Show InChI InChI=1S/C21H18FN5O3/c1-14-3-2-4-15(9-14)20-19(24-13-30-20)21(28)26-17-11-25-27(12-17)7-8-29-18-6-5-16(22)10-23-18/h2-6,9-13H,7-8H2,1H3,(H,26,28)
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n/an/a 2.10E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221417
PNG
(US9303023, 114)
Show SMILES Cc1cnc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)nc1
Show InChI InChI=1S/C21H21N7O2/c1-14-4-3-5-16(8-14)19-18(25-13-30-19)20(29)27-17-11-26-28(12-17)7-6-22-21-23-9-15(2)10-24-21/h3-5,8-13H,6-7H2,1-2H3,(H,27,29)(H,22,23,24)
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n/an/a 2.61E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221425
PNG
(US9303023, 122)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cn(CCNc2nc3ccccc3o2)cn1
Show InChI InChI=1S/C23H20N6O3/c1-15-5-4-6-16(11-15)21-20(26-14-31-21)22(30)28-19-12-29(13-25-19)10-9-24-23-27-17-7-2-3-8-18(17)32-23/h2-8,11-14H,9-10H2,1H3,(H,24,27)(H,28,30)
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n/an/a 2.78E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221352
PNG
(US9303023, 48)
Show SMILES COc1cc(ccc1C)-c1ocnc1C(=O)Nc1cnn(CCn2c(C)nc3ccccc23)c1
Show InChI InChI=1S/C25H24N6O3/c1-16-8-9-18(12-22(16)33-3)24-23(26-15-34-24)25(32)29-19-13-27-30(14-19)10-11-31-17(2)28-20-6-4-5-7-21(20)31/h4-9,12-15H,10-11H2,1-3H3,(H,29,32)
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n/an/a 3.80E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221415
PNG
(US9303023, 112)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCNc2nc3cc(Cl)ccc3o2)c1
Show InChI InChI=1S/C23H19ClN6O3/c1-14-3-2-4-15(9-14)21-20(26-13-32-21)22(31)28-17-11-27-30(12-17)8-7-25-23-29-18-10-16(24)5-6-19(18)33-23/h2-6,9-13H,7-8H2,1H3,(H,25,29)(H,28,31)
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n/an/a 5.07E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
Orexin receptor 2


(Homo sapiens (Human))
BDBM221324
PNG
(US9303023, 23)
Show SMILES COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3ccncn3)cn2)n1
Show InChI InChI=1S/C19H19N9O4/c1-30-14-7-15(31-2)27-19(26-14)21-5-6-28-9-12(8-24-28)25-18(29)16-17(32-11-23-16)13-3-4-20-10-22-13/h3-4,7-11H,5-6H2,1-2H3,(H,25,29)(H,21,26,27)
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n/an/a 9.02E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%