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Patent code US9303033

Compile Data Set for Download or QSAR

Found 2239 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218843
PNG
(US9303033, A1, Example 5)
Show SMILES Nc1cc(Nc2cccc(Cl)c2)nc2c(\C=C3/NC(=O)NC3=O)cnn12
Show InChI InChI=1S/C16H12ClN7O2/c17-9-2-1-3-10(5-9)20-13-6-12(18)24-14(22-13)8(7-19-24)4-11-15(25)23-16(26)21-11/h1-7H,18H2,(H,20,22)(H2,21,23,25,26)/b11-4-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM220066
PNG
(BDBM220085 | US9303033, J48, Table 58A, Compound 3...)
Show SMILES Cc1ccccc1-c1cc(F)ccc1CNc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C27H24FN7O2/c1-15-4-2-3-5-20(15)21-11-18(28)7-6-16(21)13-29-23-12-24(31-19-8-9-19)35-25(33-23)17(14-30-35)10-22-26(36)34-27(37)32-22/h2-7,10-12,14,19,31H,8-9,13H2,1H3,(H,29,33)(H2,32,34,36,37)/b22-10-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM220055
PNG
(US9303033, E49, Table 59A, Compound 15 | US9303033...)
Show SMILES COc1ccnc(COc2nc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)c1
Show InChI InChI=1S/C19H18N8O4/c1-30-13-4-5-20-12(7-13)9-31-19-24-15-10(6-14-16(28)25-18(29)23-14)8-21-27(15)17(26-19)22-11-2-3-11/h4-8,11H,2-3,9H2,1H3,(H,22,24,26)(H2,23,25,28,29)/b14-6-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219809
PNG
(US9303033, P38, Table 41A, Compound 54)
Show SMILES FC(F)(F)C1(CC1)C(=O)N[C@H]1CC[C@@H](CC1)Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C23H26F3N9O3/c24-23(25,26)22(7-8-22)18(37)28-12-1-3-13(4-2-12)29-19-32-16-11(9-15-17(36)33-21(38)31-15)10-27-35(16)20(34-19)30-14-5-6-14/h9-10,12-14H,1-8H2,(H,28,37)(H2,29,30,32,34)(H2,31,33,36,38)/b15-9-/t12-,13-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219813
PNG
(US9303033, T38, Table 41A, Compound 58)
Show SMILES CC(C)CN[C@H]1CC[C@@H](CC1)Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C22H31N9O2/c1-12(2)10-23-14-3-5-15(6-4-14)25-20-28-18-13(9-17-19(32)29-22(33)27-17)11-24-31(18)21(30-20)26-16-7-8-16/h9,11-12,14-16,23H,3-8,10H2,1-2H3,(H2,25,26,28,30)(H2,27,29,32,33)/b17-9-/t14-,15-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218860
PNG
(US9303033, C39, Table 43A, Compound 6 | US9303033,...)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)cc(Nc3ccc(cc3)-n3cccn3)nc12
Show InChI InChI=1S/C22H19N9O2/c32-21-17(27-22(33)29-21)10-13-12-24-31-19(26-15-2-3-15)11-18(28-20(13)31)25-14-4-6-16(7-5-14)30-9-1-8-23-30/h1,4-12,15,26H,2-3H2,(H,25,28)(H2,27,29,32,33)/b17-10-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219827
PNG
(US9303033, H39, Table 43A, Compound 11)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)cc(Nc3cccnc3)nc12
Show InChI InChI=1S/C18H16N8O2/c27-17-13(23-18(28)25-17)6-10-8-20-26-15(22-11-3-4-11)7-14(24-16(10)26)21-12-2-1-5-19-9-12/h1-2,5-9,11,22H,3-4H2,(H,21,24)(H2,23,25,27,28)/b13-6-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219832
PNG
(US9303033, M39, Table 43A, Compound 16)
Show SMILES Fc1ccc(F)c(Nc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)c1
Show InChI InChI=1S/C19H15F2N7O2/c20-10-1-4-12(21)13(6-10)24-15-7-16(23-11-2-3-11)28-17(26-15)9(8-22-28)5-14-18(29)27-19(30)25-14/h1,4-8,11,23H,2-3H2,(H,24,26)(H2,25,27,29,30)/b14-5-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219836
PNG
(US9303033, Q39, Table 43A, Compound 20)
Show SMILES Fc1ccc(Cl)c(Nc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)c1
Show InChI InChI=1S/C19H15ClFN7O2/c20-12-4-1-10(21)6-13(12)24-15-7-16(23-11-2-3-11)28-17(26-15)9(8-22-28)5-14-18(29)27-19(30)25-14/h1,4-8,11,23H,2-3H2,(H,24,26)(H2,25,27,29,30)/b14-5-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219840
PNG
(US9303033, U39, Table 43A, Compound 24)
Show SMILES Cc1cc(F)ccc1Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C20H18FN7O2/c1-10-6-12(21)2-5-14(10)24-16-8-17(23-13-3-4-13)28-18(26-16)11(9-22-28)7-15-19(29)27-20(30)25-15/h2,5-9,13,23H,3-4H2,1H3,(H,24,26)(H2,25,27,29,30)/b15-7-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219856
PNG
(US9303033, K40, Table 43A, Compound 40)
Show SMILES Clc1cc(ccc1Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)-n1ccnc1
Show InChI InChI=1S/C22H18ClN9O2/c23-15-8-14(31-6-5-24-11-31)3-4-16(15)27-18-9-19(26-13-1-2-13)32-20(29-18)12(10-25-32)7-17-21(33)30-22(34)28-17/h3-11,13,26H,1-2H2,(H,27,29)(H2,28,30,33,34)/b17-7-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219944
PNG
(US9303033, U43, Table 50A, Compound 26)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)cc(NCc3ccnc(c3)N3CCOCC3)nc12
Show InChI InChI=1S/C23H25N9O3/c33-22-17(28-23(34)30-22)10-15-13-26-32-20(27-16-1-2-16)11-18(29-21(15)32)25-12-14-3-4-24-19(9-14)31-5-7-35-8-6-31/h3-4,9-11,13,16,27H,1-2,5-8,12H2,(H,25,29)(H2,28,30,33,34)/b17-10-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219974
PNG
(US9303033, Y44, Table 50A, Compound 56)
Show SMILES CC(Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)c1cc(C)ccn1
Show InChI InChI=1S/C21H22N8O2/c1-11-5-6-22-15(7-11)12(2)24-17-9-18(25-14-3-4-14)29-19(27-17)13(10-23-29)8-16-20(30)28-21(31)26-16/h5-10,12,14,25H,3-4H2,1-2H3,(H,24,27)(H2,26,28,30,31)/b16-8-
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SENHWA BIOSCIENCES, INC.

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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM220003
PNG
(US9303033, B46, Table 51A, Compound 1)
Show SMILES Cc1c(Nc2cccc(Cl)c2)nc2c(\C=C3/NC(=O)NC3=O)cnn2c1NC1CC1
Show InChI InChI=1S/C20H18ClN7O2/c1-10-16(23-14-4-2-3-12(21)8-14)26-18-11(7-15-19(29)27-20(30)25-15)9-22-28(18)17(10)24-13-5-6-13/h2-4,7-9,13,24H,5-6H2,1H3,(H,23,26)(H2,25,27,29,30)/b15-7-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219864
PNG
(US9303033, S40, Table 43A, Compound 48)
Show SMILES COc1ccc(Cl)cc1Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C20H18ClN7O3/c1-31-15-5-2-11(21)7-13(15)24-16-8-17(23-12-3-4-12)28-18(26-16)10(9-22-28)6-14-19(29)27-20(30)25-14/h2,5-9,12,23H,3-4H2,1H3,(H,24,26)(H2,25,27,29,30)/b14-6-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218861
PNG
(US9303033, E39, Table 43A, Compound 8 | US9303033,...)
Show SMILES Fc1ccc(Nc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)cc1Cl
Show InChI InChI=1S/C19H15ClFN7O2/c20-12-6-11(3-4-13(12)21)23-15-7-16(24-10-1-2-10)28-17(26-15)9(8-22-28)5-14-18(29)27-19(30)25-14/h3-8,10,24H,1-2H2,(H,23,26)(H2,25,27,29,30)/b14-5-
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SENHWA BIOSCIENCES, INC.

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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218876
PNG
(US9303033, H2, Table 6A, Compound 15)
Show SMILES Clc1ccc(Nc2cc(NCC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)nc1
Show InChI InChI=1S/C19H17ClN8O2/c20-12-3-4-14(21-9-12)25-15-6-16(22-7-10-1-2-10)28-17(26-15)11(8-23-28)5-13-18(29)27-19(30)24-13/h3-6,8-10,22H,1-2,7H2,(H,21,25,26)(H2,24,27,29,30)/b13-5-
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218883
PNG
(US9303033, O2, Example 27)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)cc(NC3CCCC3)nc12
Show InChI InChI=1S/C18H21N7O2/c26-17-13(22-18(27)24-17)7-10-9-19-25-15(21-12-5-6-12)8-14(23-16(10)25)20-11-3-1-2-4-11/h7-9,11-12,21H,1-6H2,(H,20,23)(H2,22,24,26,27)/b13-7-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218888
PNG
(US9303033, T2, Table 9A, Compound 5)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)cc(NCC3CC3)nc12
Show InChI InChI=1S/C17H19N7O2/c25-16-12(21-17(26)23-16)5-10-8-19-24-14(20-11-3-4-11)6-13(22-15(10)24)18-7-9-1-2-9/h5-6,8-9,11,20H,1-4,7H2,(H,18,22)(H2,21,23,25,26)/b12-5-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218892
PNG
(US9303033, Q45, Table 50A, Compound 74 | US9303033...)
Show SMILES C[C@@H](Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)C1CC1
Show InChI InChI=1S/C18H21N7O2/c1-9(10-2-3-10)20-14-7-15(21-12-4-5-12)25-16(23-14)11(8-19-25)6-13-17(26)24-18(27)22-13/h6-10,12,21H,2-5H2,1H3,(H,20,23)(H2,22,24,26,27)/b13-6-/t9-/m1/s1
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


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More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218917
PNG
(US9303033, J7, Table 22A, Compound 4 | US9303033, ...)
Show SMILES CS(=O)(=O)c1cccc(c1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C20H18N6O4S/c1-31(29,30)14-4-2-3-11(7-14)15-9-17(22-13-5-6-13)26-18(23-15)12(10-21-26)8-16-19(27)25-20(28)24-16/h2-4,7-10,13,22H,5-6H2,1H3,(H2,24,25,27,28)/b16-8-
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US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218858
PNG
(US9303033, P1, Table 4A, Compound 10)
Show SMILES COc1cccc(Nc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)c1Cl
Show InChI InChI=1S/C20H18ClN7O3/c1-31-14-4-2-3-12(17(14)21)24-15-8-16(23-11-5-6-11)28-18(26-15)10(9-22-28)7-13-19(29)27-20(30)25-13/h2-4,7-9,11,23H,5-6H2,1H3,(H,24,26)(H2,25,27,29,30)/b13-7-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218951
PNG
(US9303033, F5, Table 14A, Compound 3)
Show SMILES Fc1ccc(cc1C(=O)N1CCOCC1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C24H22FN7O4/c25-17-4-1-13(9-16(17)23(34)31-5-7-36-8-6-31)18-11-20(27-15-2-3-15)32-21(28-18)14(12-26-32)10-19-22(33)30-24(35)29-19/h1,4,9-12,15,27H,2-3,5-8H2,(H2,29,30,33,35)/b19-10-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218987
PNG
(US9303033, O6, Table 19A, Compound 14)
Show SMILES FC(F)(F)CNc1cc(Nc2cccc(Cl)c2)nc2c(\C=C3/NC(=O)NC3=O)cnn12
Show InChI InChI=1S/C18H13ClF3N7O2/c19-10-2-1-3-11(5-10)25-13-6-14(23-8-18(20,21)22)29-15(27-13)9(7-24-29)4-12-16(30)28-17(31)26-12/h1-7,23H,8H2,(H,25,27)(H2,26,28,30,31)/b12-4-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219005
PNG
(US9303033, Example 96, Table 21, Compound 1)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)cc(Cc3cccc(c3)C#N)nc12
Show InChI InChI=1S/C21H17N7O2/c22-10-13-3-1-2-12(6-13)7-16-9-18(24-15-4-5-15)28-19(25-16)14(11-23-28)8-17-20(29)27-21(30)26-17/h1-3,6,8-9,11,15,24H,4-5,7H2,(H2,26,27,29,30)/b17-8-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218916
PNG
(US9303033, I7, Table 22A, Compound 3 | US9303033, ...)
Show SMILES COC(=O)c1cccc(c1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C21H18N6O4/c1-31-20(29)12-4-2-3-11(7-12)15-9-17(23-14-5-6-14)27-18(24-15)13(10-22-27)8-16-19(28)26-21(30)25-16/h2-4,7-10,14,23H,5-6H2,1H3,(H2,25,26,28,30)/b16-8-
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US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218919
PNG
(US9303033, L7, Table 22A, Compound 6 | US9303033, ...)
Show SMILES CN(C)CCCOc1cccc(c1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C24H27N7O3/c1-30(2)9-4-10-34-18-6-3-5-15(11-18)19-13-21(26-17-7-8-17)31-22(27-19)16(14-25-31)12-20-23(32)29-24(33)28-20/h3,5-6,11-14,17,26H,4,7-10H2,1-2H3,(H2,28,29,32,33)/b20-12-
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US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218926
PNG
(US9303033, G4, Table 13A, Compound 15 | US9303033,...)
Show SMILES Cc1cc(COc2cccc(c2)-c2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)no1
Show InChI InChI=1S/C24H21N7O4/c1-13-7-17(30-35-13)12-34-18-4-2-3-14(8-18)19-10-21(26-16-5-6-16)31-22(27-19)15(11-25-31)9-20-23(32)29-24(33)28-20/h2-4,7-11,16,26H,5-6,12H2,1H3,(H2,28,29,32,33)/b20-9-
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219045
PNG
(US9303033, T8, Table 23A, Compound 2)
Show SMILES NC(=O)c1ccc(s1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C18H15N7O3S/c19-15(26)13-4-3-12(29-13)10-6-14(21-9-1-2-9)25-16(22-10)8(7-20-25)5-11-17(27)24-18(28)23-11/h3-7,9,21H,1-2H2,(H2,19,26)(H2,23,24,27,28)/b11-5-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219046
PNG
(US9303033, U8, Table 23A, Compound 3)
Show SMILES CNC(=O)c1ccc(s1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C19H17N7O3S/c1-20-18(28)14-5-4-13(30-14)11-7-15(22-10-2-3-10)26-16(23-11)9(8-21-26)6-12-17(27)25-19(29)24-12/h4-8,10,22H,2-3H2,1H3,(H,20,28)(H2,24,25,27,29)/b12-6-
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US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219050
PNG
(US9303033, Y8, Table 23A, Compound 7)
Show SMILES FC(F)(F)CNC(=O)c1ccc(s1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C20H16F3N7O3S/c21-20(22,23)8-24-18(32)14-4-3-13(34-14)11-6-15(26-10-1-2-10)30-16(27-11)9(7-25-30)5-12-17(31)29-19(33)28-12/h3-7,10,26H,1-2,8H2,(H,24,32)(H2,28,29,31,33)/b12-5-
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219054
PNG
(US9303033, C9, Table 23A, Compound 11)
Show SMILES CN1CCCN(CC1)C(=O)c1ccc(s1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C24H26N8O3S/c1-30-7-2-8-31(10-9-30)23(34)19-6-5-18(36-19)16-12-20(26-15-3-4-15)32-21(27-16)14(13-25-32)11-17-22(33)29-24(35)28-17/h5-6,11-13,15,26H,2-4,7-10H2,1H3,(H2,28,29,33,35)/b17-11-
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US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219066
PNG
(US9303033, O9, Table 23A, Compound 23)
Show SMILES CN(C1CCN(C)C1)C(=O)c1ccc(s1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C24H26N8O3S/c1-30-8-7-15(12-30)31(2)23(34)19-6-5-18(36-19)16-10-20(26-14-3-4-14)32-21(27-16)13(11-25-32)9-17-22(33)29-24(35)28-17/h5-6,9-11,14-15,26H,3-4,7-8,12H2,1-2H3,(H2,28,29,33,35)/b17-9-
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US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219076
PNG
(US9303033, Y9, Table 23A, Compound 33)
Show SMILES O=C(NCC1CCCN1)c1ccc(s1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C23H24N8O3S/c32-21-16(29-23(34)30-21)8-12-10-26-31-19(27-13-3-4-13)9-15(28-20(12)31)17-5-6-18(35-17)22(33)25-11-14-2-1-7-24-14/h5-6,8-10,13-14,24,27H,1-4,7,11H2,(H,25,33)(H2,29,30,32,34)/b16-8-
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US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219081
PNG
(US9303033, D10, Table 23A, Compound 38)
Show SMILES CC(C)[C@H](CO)NC(=O)c1ccc(s1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C23H25N7O4S/c1-11(2)16(10-31)27-22(33)18-6-5-17(35-18)14-8-19(25-13-3-4-13)30-20(26-14)12(9-24-30)7-15-21(32)29-23(34)28-15/h5-9,11,13,16,25,31H,3-4,10H2,1-2H3,(H,27,33)(H2,28,29,32,34)/b15-7-/t16-/m0/s1
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US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219082
PNG
(US9303033, E10, Table 23A, Compound 39)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1ccc(s1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C25H28N8O3S/c1-2-32-9-3-4-16(32)13-26-24(35)20-8-7-19(37-20)17-11-21(28-15-5-6-15)33-22(29-17)14(12-27-33)10-18-23(34)31-25(36)30-18/h7-8,10-12,15-16,28H,2-6,9,13H2,1H3,(H,26,35)(H2,30,31,34,36)/b18-10-/t16-/m0/s1
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US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219091
PNG
(US9303033, N10, Table 23A, Compound 48 | US9303033...)
Show SMILES CC1CN(Cc2ccc(s2)-c2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)CC(C)O1
Show InChI InChI=1S/C24H27N7O3S/c1-13-10-30(11-14(2)34-13)12-17-5-6-20(35-17)18-8-21(26-16-3-4-16)31-22(27-18)15(9-25-31)7-19-23(32)29-24(33)28-19/h5-9,13-14,16,26H,3-4,10-12H2,1-2H3,(H2,28,29,32,33)/b19-7-
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219096
PNG
(US9303033, S10, Table 23A, Compound 53)
Show SMILES O=C(NCCCCN1CCCC1)c1ccc(s1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C26H30N8O3S/c35-24-19(31-26(37)32-24)13-16-15-28-34-22(29-17-5-6-17)14-18(30-23(16)34)20-7-8-21(38-20)25(36)27-9-1-2-10-33-11-3-4-12-33/h7-8,13-15,17,29H,1-6,9-12H2,(H,27,36)(H2,31,32,35,37)/b19-13-
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219113
PNG
(US9303033, J11, Table 23A, Compound 70)
Show SMILES CCN(CC)CCNC(=O)c1ccc(s1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C24H28N8O3S/c1-3-31(4-2)10-9-25-23(34)19-8-7-18(36-19)16-12-20(27-15-5-6-15)32-21(28-16)14(13-26-32)11-17-22(33)30-24(35)29-17/h7-8,11-13,15,27H,3-6,9-10H2,1-2H3,(H,25,34)(H2,29,30,33,35)/b17-11-
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219120
PNG
(US9303033, Q11, Table 23A, Compound 77)
Show SMILES CN(C)CCCNC(=O)c1ccc(s1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C23H26N8O3S/c1-30(2)9-3-8-24-22(33)18-7-6-17(35-18)15-11-19(26-14-4-5-14)31-20(27-15)13(12-25-31)10-16-21(32)29-23(34)28-16/h6-7,10-12,14,26H,3-5,8-9H2,1-2H3,(H,24,33)(H2,28,29,32,34)/b16-10-
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


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More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219142
PNG
(US9303033, M12, Table 23A, Compound 99)
Show SMILES O=C(NC1CCNC1)c1ccc(s1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C22H22N8O3S/c31-20-15(28-22(33)29-20)7-11-9-24-30-18(25-12-1-2-12)8-14(27-19(11)30)16-3-4-17(34-16)21(32)26-13-5-6-23-10-13/h3-4,7-9,12-13,23,25H,1-2,5-6,10H2,(H,26,32)(H2,28,29,31,33)/b15-7-
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219143
PNG
(US9303033, N12, Table 23A, Compound 100)
Show SMILES N[C@@H]1CCN(C1)C(=O)c1ccc(s1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C22H22N8O3S/c23-12-5-6-29(10-12)21(32)17-4-3-16(34-17)14-8-18(25-13-1-2-13)30-19(26-14)11(9-24-30)7-15-20(31)28-22(33)27-15/h3-4,7-9,12-13,25H,1-2,5-6,10,23H2,(H2,27,28,31,33)/b15-7-/t12-/m1/s1
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219151
PNG
(US9303033, W12, Table 23A, Compound 109)
Show SMILES O=C(NCCc1ccccn1)c1ccc(s1)-c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C25H22N8O3S/c34-23-18(31-25(36)32-23)11-14-13-28-33-21(29-16-4-5-16)12-17(30-22(14)33)19-6-7-20(37-19)24(35)27-10-8-15-3-1-2-9-26-15/h1-3,6-7,9,11-13,16,29H,4-5,8,10H2,(H,27,35)(H2,31,32,34,36)/b18-11-
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219137
PNG
(US9303033, H12, Table 23A, Compound 94 | US9303033...)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)cc(nc12)-c1ccc(CN2CCOCC2)s1
Show InChI InChI=1S/C22H23N7O3S/c30-21-17(26-22(31)27-21)9-13-11-23-29-19(24-14-1-2-14)10-16(25-20(13)29)18-4-3-15(33-18)12-28-5-7-32-8-6-28/h3-4,9-11,14,24H,1-2,5-8,12H2,(H2,26,27,30,31)/b17-9-
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219191
PNG
(US9303033, M14, Table 33A, Compound 6)
Show SMILES Fc1cccc(Nc2nc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)c1
Show InChI InChI=1S/C18H15FN8O2/c19-10-2-1-3-12(7-10)21-16-24-14-9(6-13-15(28)25-18(29)23-13)8-20-27(14)17(26-16)22-11-4-5-11/h1-3,6-8,11H,4-5H2,(H2,21,22,24,26)(H2,23,25,28,29)/b13-6-
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SENHWA BIOSCIENCES, INC.

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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219194
PNG
(US9303033, P14, Table 33A, Compound 9)
Show SMILES Fc1ccc(Nc2nc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)cc1
Show InChI InChI=1S/C18H15FN8O2/c19-10-1-3-11(4-2-10)21-16-24-14-9(7-13-15(28)25-18(29)23-13)8-20-27(14)17(26-16)22-12-5-6-12/h1-4,7-8,12H,5-6H2,(H2,21,22,24,26)(H2,23,25,28,29)/b13-7-
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219196
PNG
(US9303033, R14, Table 33A, Compound 11)
Show SMILES NCc1ccc(Nc2nc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)cc1
Show InChI InChI=1S/C19H19N9O2/c20-8-10-1-3-12(4-2-10)22-17-25-15-11(7-14-16(29)26-19(30)24-14)9-21-28(15)18(27-17)23-13-5-6-13/h1-4,7,9,13H,5-6,8,20H2,(H2,22,23,25,27)(H2,24,26,29,30)/b14-7-
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219229
PNG
(US9303033, Z15, Table 33A, Compound 45)
Show SMILES FC(F)(F)Oc1cccc(Nc2nc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)c1
Show InChI InChI=1S/C19H15F3N8O3/c20-19(21,22)33-12-3-1-2-11(7-12)24-16-27-14-9(6-13-15(31)28-18(32)26-13)8-23-30(14)17(29-16)25-10-4-5-10/h1-3,6-8,10H,4-5H2,(H2,24,25,27,29)(H2,26,28,31,32)/b13-6-
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219250
PNG
(US9303033, U16, Table 33A, Compound 66)
Show SMILES FC1CCN(CC1)c1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C17H19FN8O2/c18-10-3-5-25(6-4-10)15-22-13-9(7-12-14(27)23-17(28)21-12)8-19-26(13)16(24-15)20-11-1-2-11/h7-8,10-11H,1-6H2,(H,20,22,24)(H2,21,23,27,28)/b12-7-
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219282
PNG
(US9303033, A18, Table 33A, Compound 98)
Show SMILES C[C@@H](Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)C1CC1
Show InChI InChI=1S/C17H20N8O2/c1-8(9-2-3-9)19-15-22-13-10(6-12-14(26)23-17(27)21-12)7-18-25(13)16(24-15)20-11-4-5-11/h6-9,11H,2-5H2,1H3,(H2,19,20,22,24)(H2,21,23,26,27)/b12-6-/t8-/m1/s1
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Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%