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Patent code US9315491

Compile Data Set for Download or QSAR
Found 129 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222632
PNG
(US9315491, MTR-0391)
Show SMILES CSc1c(nc(nc1-c1ccncc1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1)N1CCOCC1
Show InChI InChI=1S/C31H31N7O4S/c1-43-28-27(21-10-12-32-13-11-21)35-29(36-30(28)37-14-17-41-18-15-37)22-2-4-23(5-3-22)33-31(40)34-24-6-8-25(9-7-24)38-16-19-42-20-26(38)39/h2-13H,14-20H2,1H3,(H2,33,34,40)
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US Patent
n/an/a 5.40n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222657
PNG
(US9315491, MTR-0457)
Show SMILES CSc1c(nc(nc1-c1cccnc1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1)N1CCOCC1
Show InChI InChI=1S/C31H31N7O4S/c1-43-28-27(22-3-2-12-32-19-22)35-29(36-30(28)37-13-16-41-17-14-37)21-4-6-23(7-5-21)33-31(40)34-24-8-10-25(11-9-24)38-15-18-42-20-26(38)39/h2-12,19H,13-18,20H2,1H3,(H2,33,34,40)
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n/an/a 5.80n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222591
PNG
(US9315491, MTR-0262)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCSCC2)cc1
Show InChI InChI=1S/C26H30N6O3S/c1-34-23-18-27-24(30-25(23)32-10-14-35-15-11-32)19-2-4-20(5-3-19)28-26(33)29-21-6-8-22(9-7-21)31-12-16-36-17-13-31/h2-9,18H,10-17H2,1H3,(H2,28,29,33)
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n/an/a 8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222580
PNG
(US9315491, MTR-0241)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1
Show InChI InChI=1S/C26H28N6O5/c1-35-22-16-27-24(30-25(22)31-10-13-36-14-11-31)18-2-4-19(5-3-18)28-26(34)29-20-6-8-21(9-7-20)32-12-15-37-17-23(32)33/h2-9,16H,10-15,17H2,1H3,(H2,28,29,34)
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n/an/a 8.10n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222569
PNG
(US9315491, MTR-0222)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1
Show InChI InChI=1S/C30H34N6O7/c1-3-42-26-25(29(38)43-4-2)33-27(34-28(26)35-13-16-40-17-14-35)20-5-7-21(8-6-20)31-30(39)32-22-9-11-23(12-10-22)36-15-18-41-19-24(36)37/h5-12H,3-4,13-19H2,1-2H3,(H2,31,32,39)
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n/an/a 11.5n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222582
PNG
(US9315491, MTR-0244)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)cc1
Show InChI InChI=1S/C27H30N6O6/c1-3-38-22-21(26(35)39-4-2)31-24(32-25(22)33-13-15-37-16-14-33)18-7-11-20(12-8-18)30-27(36)29-19-9-5-17(6-10-19)23(28)34/h5-12H,3-4,13-16H2,1-2H3,(H2,28,34)(H2,29,30,36)
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n/an/a 18n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222572
PNG
(US9315491, MTR-0227)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1
Show InChI InChI=1S/C26H28N6O4S/c1-37-22-16-27-24(30-25(22)31-10-13-35-14-11-31)18-2-4-19(5-3-18)28-26(34)29-20-6-8-21(9-7-20)32-12-15-36-17-23(32)33/h2-9,16H,10-15,17H2,1H3,(H2,28,29,34)
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n/an/a 18.8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222633
PNG
(US9315491, MTR-0392)
Show SMILES CSc1c(nc(nc1-c1ccncc1)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)cc1)N1CCOCC1
Show InChI InChI=1S/C28H27N7O3S/c1-39-24-23(18-10-12-30-13-11-18)33-26(34-27(24)35-14-16-38-17-15-35)20-4-8-22(9-5-20)32-28(37)31-21-6-2-19(3-7-21)25(29)36/h2-13H,14-17H2,1H3,(H2,29,36)(H2,31,32,37)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222667
PNG
(US9315491, MTR-0477)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c(SC)c(n1)-c1ccncc1
Show InChI InChI=1S/C23H26N6O2S/c1-3-25-23(30)26-18-6-4-17(5-7-18)21-27-19(16-8-10-24-11-9-16)20(32-2)22(28-21)29-12-14-31-15-13-29/h4-11H,3,12-15H2,1-2H3,(H2,25,26,30)
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n/an/a 23.7n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222612
PNG
(US9315491, MTR-0325)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1
Show InChI InChI=1S/C27H30N6O5/c1-2-38-23-17-28-25(31-26(23)32-11-14-36-15-12-32)19-3-5-20(6-4-19)29-27(35)30-21-7-9-22(10-8-21)33-13-16-37-18-24(33)34/h3-10,17H,2,11-16,18H2,1H3,(H2,29,30,35)
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n/an/a 24.8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222668
PNG
(US9315491, MTR-0478)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c(SC)c(n1)-c1ccncc1
Show InChI InChI=1S/C22H24N6O2S/c1-23-22(29)25-17-5-3-16(4-6-17)20-26-18(15-7-9-24-10-8-15)19(31-2)21(27-20)28-11-13-30-14-12-28/h3-10H,11-14H2,1-2H3,(H2,23,25,29)
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n/an/a 25.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222618
PNG
(US9315491, MTR-0358)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C22H23ClN6O4S2/c1-34-18-19(23)27-20(28-21(18)29-10-12-33-13-11-29)14-2-4-15(5-3-14)25-22(30)26-16-6-8-17(9-7-16)35(24,31)32/h2-9H,10-13H2,1H3,(H2,24,31,32)(H2,25,26,30)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222643
PNG
(US9315491, MTR-0424)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C24H27N5O5S/c1-3-34-21-16-25-22(28-23(21)29-12-14-33-15-13-29)17-4-6-18(7-5-17)26-24(30)27-19-8-10-20(11-9-19)35(2,31)32/h4-11,16H,3,12-15H2,1-2H3,(H2,26,27,30)
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n/an/a 30.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222653
PNG
(US9315491, MTR-0453)
Show SMILES CSc1c(nc(nc1-c1ccncc1)-c1ccc(NC(=O)Nc2ccncc2)cc1)N1CCOCC1
Show InChI InChI=1S/C26H25N7O2S/c1-36-23-22(18-6-10-27-11-7-18)31-24(32-25(23)33-14-16-35-17-15-33)19-2-4-20(5-3-19)29-26(34)30-21-8-12-28-13-9-21/h2-13H,14-17H2,1H3,(H2,28,29,30,34)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222602
PNG
(US9315491, MTR-0283)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C22H24N6O5S/c1-32-19-14-24-20(27-21(19)28-10-12-33-13-11-28)15-2-4-16(5-3-15)25-22(29)26-17-6-8-18(9-7-17)34(23,30)31/h2-9,14H,10-13H2,1H3,(H2,23,30,31)(H2,25,26,29)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222648
PNG
(US9315491, MTR-0442)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(NC(C)=O)nc2)cc1
Show InChI InChI=1S/C24H27N7O4/c1-3-35-20-15-26-22(30-23(20)31-10-12-34-13-11-31)17-4-6-18(7-5-17)28-24(33)29-19-8-9-21(25-14-19)27-16(2)32/h4-9,14-15H,3,10-13H2,1-2H3,(H,25,27,32)(H2,28,29,33)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222613
PNG
(US9315491, MTR-0326)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C23H26N6O5S/c1-2-34-20-15-25-21(28-22(20)29-11-13-33-14-12-29)16-3-5-17(6-4-16)26-23(30)27-18-7-9-19(10-8-18)35(24,31)32/h3-10,15H,2,11-14H2,1H3,(H2,24,31,32)(H2,26,27,30)
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n/an/a 40.9n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222655
PNG
(US9315491, MTR-0455)
Show SMILES O=C(Nc1ccc(cc1)N1CCOCC1=O)Nc1ccc(cc1)-c1ncc(OCCN2CCOCC2)c(n1)N1CCOCC1
Show InChI InChI=1S/C31H37N7O6/c39-28-22-43-19-14-38(28)26-7-5-25(6-8-26)34-31(40)33-24-3-1-23(2-4-24)29-32-21-27(30(35-29)37-12-17-42-18-13-37)44-20-11-36-9-15-41-16-10-36/h1-8,21H,9-20,22H2,(H2,33,34,40)
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n/an/a 42.3n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222601
PNG
(US9315491, MTR-0282)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)cc1
Show InChI InChI=1S/C23H24N6O4/c1-32-19-14-25-21(28-22(19)29-10-12-33-13-11-29)16-4-8-18(9-5-16)27-23(31)26-17-6-2-15(3-7-17)20(24)30/h2-9,14H,10-13H2,1H3,(H2,24,30)(H2,26,27,31)
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n/an/a 47.7n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222660
PNG
(US9315491, MTR-0463)
Show SMILES CSc1c(nc(nc1-c1cccnc1)-c1ccc(NC(=O)Nc2ccc(NS(C)(=O)=O)cc2)cc1)N1CCOCC1
Show InChI InChI=1S/C28H29N7O4S2/c1-40-25-24(20-4-3-13-29-18-20)32-26(33-27(25)35-14-16-39-17-15-35)19-5-7-21(8-6-19)30-28(36)31-22-9-11-23(12-10-22)34-41(2,37)38/h3-13,18,34H,14-17H2,1-2H3,(H2,30,31,36)
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n/an/a 47.8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222606
PNG
(US9315491, MTR-0308)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C27H29ClN6O4S/c1-39-22-23(28)31-24(32-25(22)33-10-14-37-15-11-33)18-2-6-20(7-3-18)29-27(36)30-21-8-4-19(5-9-21)26(35)34-12-16-38-17-13-34/h2-9H,10-17H2,1H3,(H2,29,30,36)
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n/an/a 48.6n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222637
PNG
(US9315491, MTR-0405)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)c(F)c1
Show InChI InChI=1S/C26H27FN6O5/c1-36-22-15-28-24(31-25(22)32-8-11-37-12-9-32)17-2-7-21(20(27)14-17)30-26(35)29-18-3-5-19(6-4-18)33-10-13-38-16-23(33)34/h2-7,14-15H,8-13,16H2,1H3,(H2,29,30,35)
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n/an/a 49.5n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222611
PNG
(US9315491, MTR-0323)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)cc1
Show InChI InChI=1S/C24H26N6O4/c1-2-34-20-15-26-22(29-23(20)30-11-13-33-14-12-30)17-5-9-19(10-6-17)28-24(32)27-18-7-3-16(4-8-18)21(25)31/h3-10,15H,2,11-14H2,1H3,(H2,25,31)(H2,27,28,32)
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n/an/a 50.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222647
PNG
(US9315491, MTR-0438)
Show SMILES CSc1c(nc(nc1-c1cccnc1)-c1ccc(NC(=O)Nc2ccccc2)cc1)N1CCOCC1
Show InChI InChI=1S/C27H26N6O2S/c1-36-24-23(20-6-5-13-28-18-20)31-25(32-26(24)33-14-16-35-17-15-33)19-9-11-22(12-10-19)30-27(34)29-21-7-3-2-4-8-21/h2-13,18H,14-17H2,1H3,(H2,29,30,34)
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n/an/a 51.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222565
PNG
(US9315491, MTR-0215)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C27H32ClN7O2S/c1-33-11-13-34(14-12-33)22-9-7-21(8-10-22)30-27(36)29-20-5-3-19(4-6-20)25-31-24(28)23(38-2)26(32-25)35-15-17-37-18-16-35/h3-10H,11-18H2,1-2H3,(H2,29,30,36)
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n/an/a 52.5n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222650
PNG
(US9315491, MTR-0446)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccncc2)cc1
Show InChI InChI=1S/C22H24N6O3/c1-2-31-19-15-24-20(27-21(19)28-11-13-30-14-12-28)16-3-5-17(6-4-16)25-22(29)26-18-7-9-23-10-8-18/h3-10,15H,2,11-14H2,1H3,(H2,23,25,26,29)
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n/an/a 56.6n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222670
PNG
(US9315491, MTR-0484)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccon2)cc1
Show InChI InChI=1S/C19H19ClN6O3S/c1-30-15-16(20)23-17(24-18(15)26-7-10-28-11-8-26)12-2-4-13(5-3-12)21-19(27)22-14-6-9-29-25-14/h2-6,9H,7-8,10-11H2,1H3,(H2,21,22,25,27)
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n/an/a 58.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222642
PNG
(US9315491, MTR-0421)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C28H32N6O5/c1-2-39-24-19-29-25(32-26(24)33-11-15-37-16-12-33)20-3-7-22(8-4-20)30-28(36)31-23-9-5-21(6-10-23)27(35)34-13-17-38-18-14-34/h3-10,19H,2,11-18H2,1H3,(H2,30,31,36)
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n/an/a 58.8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222588
PNG
(US9315491, MTR-0253)
Show SMILES CCOc1c(nc(nc1C(=O)N1CCOCC1)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CCOCC1
Show InChI InChI=1S/C27H31N7O5/c1-2-39-23-22(26(35)34-12-16-38-17-13-34)31-24(32-25(23)33-10-14-37-15-11-33)19-5-7-20(8-6-19)29-27(36)30-21-4-3-9-28-18-21/h3-9,18H,2,10-17H2,1H3,(H2,29,30,36)
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n/an/a 62.5n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222635
PNG
(US9315491, MTR-0401)
Show SMILES CS(=O)c1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1
Show InChI InChI=1S/C26H28N6O5S/c1-38(35)22-16-27-24(30-25(22)31-10-13-36-14-11-31)18-2-4-19(5-3-18)28-26(34)29-20-6-8-21(9-7-20)32-12-15-37-17-23(32)33/h2-9,16H,10-15,17H2,1H3,(H2,28,29,34)
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n/an/a 64.8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222616
PNG
(US9315491, MTR-0351)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C23H23N5O5/c1-32-19-14-24-20(27-21(19)28-10-12-33-13-11-28)15-2-6-17(7-3-15)25-23(31)26-18-8-4-16(5-9-18)22(29)30/h2-9,14H,10-13H2,1H3,(H,29,30)(H2,25,26,31)
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n/an/a 65.7n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222641
PNG
(US9315491, MTR-0420)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCN(CC2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C28H35N7O5S/c1-3-40-25-20-29-26(32-27(25)34-16-18-39-19-17-34)21-4-6-22(7-5-21)30-28(36)31-23-8-10-24(11-9-23)33-12-14-35(15-13-33)41(2,37)38/h4-11,20H,3,12-19H2,1-2H3,(H2,30,31,36)
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n/an/a 65.7n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222600
PNG
(US9315491, MTR-0278)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C31H36N6O7/c1-3-43-26-25(30(39)44-4-2)34-27(35-28(26)36-13-17-41-18-14-36)21-5-9-23(10-6-21)32-31(40)33-24-11-7-22(8-12-24)29(38)37-15-19-42-20-16-37/h5-12H,3-4,13-20H2,1-2H3,(H2,32,33,40)
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n/an/a 67n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222628
PNG
(US9315491, MTR-0382)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C27H30N6O5/c1-36-23-18-28-24(31-25(23)32-10-14-37-15-11-32)19-2-6-21(7-3-19)29-27(35)30-22-8-4-20(5-9-22)26(34)33-12-16-38-17-13-33/h2-9,18H,10-17H2,1H3,(H2,29,30,35)
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n/an/a 67.7n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222646
PNG
(US9315491, MTR-0436)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)N2CCC(CC2)N(C)C)cc1
Show InChI InChI=1S/C30H36ClN7O3S/c1-36(2)24-12-14-38(15-13-24)29(39)21-6-10-23(11-7-21)33-30(40)32-22-8-4-20(5-9-22)27-34-26(31)25(42-3)28(35-27)37-16-18-41-19-17-37/h4-11,24H,12-19H2,1-3H3,(H2,32,33,40)
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n/an/a 69.4n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222619
PNG
(US9315491, MTR-0364)
Show SMILES CCOc1c(nc(nc1C(=O)N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)cc1)N1CCOCC1
Show InChI InChI=1S/C29H33N7O6/c1-2-42-24-23(28(38)36-13-17-41-18-14-36)33-26(34-27(24)35-11-15-40-16-12-35)20-5-9-22(10-6-20)32-29(39)31-21-7-3-19(4-8-21)25(30)37/h3-10H,2,11-18H2,1H3,(H2,30,37)(H2,31,32,39)
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n/an/a 70.4n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222634
PNG
(US9315491, MTR-0394)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(NS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C24H28N6O5S/c1-3-35-21-16-25-22(28-23(21)30-12-14-34-15-13-30)17-4-6-18(7-5-17)26-24(31)27-19-8-10-20(11-9-19)29-36(2,32)33/h4-11,16,29H,3,12-15H2,1-2H3,(H2,26,27,31)
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n/an/a 70.4n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222567
PNG
(US9315491, MTR-0220)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2nccs2)cc1
Show InChI InChI=1S/C23H26N6O5S/c1-3-33-18-17(21(30)34-4-2)26-19(27-20(18)29-10-12-32-13-11-29)15-5-7-16(8-6-15)25-22(31)28-23-24-9-14-35-23/h5-9,14H,3-4,10-13H2,1-2H3,(H2,24,25,28,31)
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n/an/a 72.2n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222589
PNG
(US9315491, MTR-0257)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)cc1
Show InChI InChI=1S/C23H23ClN6O3S/c1-34-18-19(24)28-21(29-22(18)30-10-12-33-13-11-30)15-4-8-17(9-5-15)27-23(32)26-16-6-2-14(3-7-16)20(25)31/h2-9H,10-13H2,1H3,(H2,25,31)(H2,26,27,32)
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n/an/a 74.4n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222661
PNG
(US9315491, MTR-0464)
Show SMILES CSc1c(nc(nc1-c1cccnc1)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CCOCC1
Show InChI InChI=1S/C26H25N7O2S/c1-36-23-22(19-4-2-10-27-16-19)31-24(32-25(23)33-12-14-35-15-13-33)18-6-8-20(9-7-18)29-26(34)30-21-5-3-11-28-17-21/h2-11,16-17H,12-15H2,1H3,(H2,29,30,34)
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n/an/a 75.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222649
PNG
(US9315491, MTR-0443)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(NC(C)=O)nc2)cc1
Show InChI InChI=1S/C27H31N7O6/c1-4-39-23-22(26(36)40-5-2)32-24(33-25(23)34-12-14-38-15-13-34)18-6-8-19(9-7-18)30-27(37)31-20-10-11-21(28-16-20)29-17(3)35/h6-11,16H,4-5,12-15H2,1-3H3,(H,28,29,35)(H2,30,31,37)
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n/an/a 76.8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222599
PNG
(US9315491, MTR-0277)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)NCCN(C)C)cc1
Show InChI InChI=1S/C31H39N7O6/c1-5-43-26-25(30(40)44-6-2)35-27(36-28(26)38-17-19-42-20-18-38)21-7-11-23(12-8-21)33-31(41)34-24-13-9-22(10-14-24)29(39)32-15-16-37(3)4/h7-14H,5-6,15-20H2,1-4H3,(H,32,39)(H2,33,34,41)
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n/an/a 78.3n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222603
PNG
(US9315491, MTR-0288)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C22H24N6O4S2/c1-33-19-14-24-20(27-21(19)28-10-12-32-13-11-28)15-2-4-16(5-3-15)25-22(29)26-17-6-8-18(9-7-17)34(23,30)31/h2-9,14H,10-13H2,1H3,(H2,23,30,31)(H2,25,26,29)
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n/an/a 78.9n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222651
PNG
(US9315491, MTR-0449)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(NS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C23H26N6O5S/c1-33-20-15-24-21(27-22(20)29-11-13-34-14-12-29)16-3-5-17(6-4-16)25-23(30)26-18-7-9-19(10-8-18)28-35(2,31)32/h3-10,15,28H,11-14H2,1-2H3,(H2,25,26,30)
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n/an/a 79.2n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222631
PNG
(US9315491, MTR-0388)
Show SMILES CSc1c(nc(nc1-c1ccncc1)-c1ccc(NC(N)=O)cc1)N1CCOCC1
Show InChI InChI=1S/C21H22N6O2S/c1-30-18-17(14-6-8-23-9-7-14)25-19(26-20(18)27-10-12-29-13-11-27)15-2-4-16(5-3-15)24-21(22)28/h2-9H,10-13H2,1H3,(H3,22,24,28)
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n/an/a 79.6n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222577
PNG
(US9315491, MTR-0233)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2)cc1
Show InChI InChI=1S/C30H36N6O6/c1-3-41-26-25(29(37)42-4-2)33-27(34-28(26)36-15-19-40-20-16-36)21-5-7-22(8-6-21)31-30(38)32-23-9-11-24(12-10-23)35-13-17-39-18-14-35/h5-12H,3-4,13-20H2,1-2H3,(H2,31,32,38)
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n/an/a 80.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222578
PNG
(US9315491, MTR-0236)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(nc2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C26H31ClN8O2S/c1-33-9-11-34(12-10-33)21-8-7-20(17-28-21)30-26(36)29-19-5-3-18(4-6-19)24-31-23(27)22(38-2)25(32-24)35-13-15-37-16-14-35/h3-8,17H,9-16H2,1-2H3,(H2,29,30,36)
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n/an/a 80.7n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222597
PNG
(US9315491, MTR-0273)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C26H30N6O7S/c1-3-38-22-21(25(33)39-4-2)30-23(31-24(22)32-13-15-37-16-14-32)17-5-7-18(8-6-17)28-26(34)29-19-9-11-20(12-10-19)40(27,35)36/h5-12H,3-4,13-16H2,1-2H3,(H2,27,35,36)(H2,28,29,34)
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n/an/a 81.1n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222573
PNG
(US9315491, MTR-0228)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2cccnc2)cc1
Show InChI InChI=1S/C21H22N6O3/c1-29-18-14-23-19(26-20(18)27-9-11-30-12-10-27)15-4-6-16(7-5-15)24-21(28)25-17-3-2-8-22-13-17/h2-8,13-14H,9-12H2,1H3,(H2,24,25,28)
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n/an/a 82.6n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222621
PNG
(US9315491, MTR-0368)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(NC(C)=O)cc2)cc1
Show InChI InChI=1S/C25H28N6O4/c1-3-35-22-16-26-23(30-24(22)31-12-14-34-15-13-31)18-4-6-20(7-5-18)28-25(33)29-21-10-8-19(9-11-21)27-17(2)32/h4-11,16H,3,12-15H2,1-2H3,(H,27,32)(H2,28,29,33)
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n/an/a 83.4n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222623
PNG
(US9315491, MTR-0370)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(NC(C)=O)cc2)cc1
Show InChI InChI=1S/C28H32N6O6/c1-4-39-24-23(27(36)40-5-2)32-25(33-26(24)34-14-16-38-17-15-34)19-6-8-21(9-7-19)30-28(37)31-22-12-10-20(11-13-22)29-18(3)35/h6-13H,4-5,14-17H2,1-3H3,(H,29,35)(H2,30,31,37)
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n/an/a 86n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222671
PNG
(US9315491, MTR-0487)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCN(CC2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C27H33N7O5S/c1-38-24-19-28-25(31-26(24)33-15-17-39-18-16-33)20-3-5-21(6-4-20)29-27(35)30-22-7-9-23(10-8-22)32-11-13-34(14-12-32)40(2,36)37/h3-10,19H,11-18H2,1-2H3,(H2,29,30,35)
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n/an/a 86.7n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222590
PNG
(US9315491, MTR-0261)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2)cc1
Show InChI InChI=1S/C26H30N6O4/c1-34-23-18-27-24(30-25(23)32-12-16-36-17-13-32)19-2-4-20(5-3-19)28-26(33)29-21-6-8-22(9-7-21)31-10-14-35-15-11-31/h2-9,18H,10-17H2,1H3,(H2,28,29,33)
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n/an/a 86.8n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222596
PNG
(US9315491, MTR-0271)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C28H32ClN7O3S/c1-34-11-13-36(14-12-34)27(37)20-5-9-22(10-6-20)31-28(38)30-21-7-3-19(4-8-21)25-32-24(29)23(40-2)26(33-25)35-15-17-39-18-16-35/h3-10H,11-18H2,1-2H3,(H2,30,31,38)
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n/an/a 89.6n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222610
PNG
(US9315491, MTR-0322)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1F
Show InChI InChI=1S/C30H33FN6O7/c1-3-43-26-25(29(39)44-4-2)34-27(35-28(26)36-11-14-41-15-12-36)22-10-7-20(17-23(22)31)33-30(40)32-19-5-8-21(9-6-19)37-13-16-42-18-24(37)38/h5-10,17H,3-4,11-16,18H2,1-2H3,(H2,32,33,40)
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n/an/a 93n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222609
PNG
(US9315491, MTR-0316)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C23H23N5O4S/c1-33-19-14-24-20(27-21(19)28-10-12-32-13-11-28)15-2-6-17(7-3-15)25-23(31)26-18-8-4-16(5-9-18)22(29)30/h2-9,14H,10-13H2,1H3,(H,29,30)(H2,25,26,31)
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n/an/a 93.9n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222584
PNG
(US9315491, MTR-0248)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2)cc1
Show InChI InChI=1S/C26H30N6O3S/c1-36-23-18-27-24(30-25(23)32-12-16-35-17-13-32)19-2-4-20(5-3-19)28-26(33)29-21-6-8-22(9-7-21)31-10-14-34-15-11-31/h2-9,18H,10-17H2,1H3,(H2,28,29,33)
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n/an/a 96.4n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222645
PNG
(US9315491, MTR-0427)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)NCCCN(C)C)cc1
Show InChI InChI=1S/C28H35N7O4/c1-34(2)14-4-13-29-27(36)21-7-11-23(12-8-21)32-28(37)31-22-9-5-20(6-10-22)25-30-19-24(38-3)26(33-25)35-15-17-39-18-16-35/h5-12,19H,4,13-18H2,1-3H3,(H,29,36)(H2,31,32,37)
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n/an/a 97.7n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222659
PNG
(US9315491, MTR-0462)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccncc2)cc1
Show InChI InChI=1S/C21H22N6O2S/c1-30-18-14-23-19(26-20(18)27-10-12-29-13-11-27)15-2-4-16(5-3-15)24-21(28)25-17-6-8-22-9-7-17/h2-9,14H,10-13H2,1H3,(H2,22,24,25,28)
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n/an/a 101n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222570
PNG
(US9315491, MTR-0225)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2cccnc2)cc1
Show InChI InChI=1S/C21H22N6O2S/c1-30-18-14-23-19(26-20(18)27-9-11-29-12-10-27)15-4-6-16(7-5-15)24-21(28)25-17-3-2-8-22-13-17/h2-8,13-14H,9-12H2,1H3,(H2,24,25,28)
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n/an/a 101n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222557
PNG
(US9315491, MTR-0184)
Show SMILES COc1c(nc(nc1C(=O)N1CCOCC1)-c1ccc(NC(=O)Nc2ccccc2)cc1)N1CCOCC1
Show InChI InChI=1S/C27H30N6O5/c1-36-23-22(26(34)33-13-17-38-18-14-33)30-24(31-25(23)32-11-15-37-16-12-32)19-7-9-21(10-8-19)29-27(35)28-20-5-3-2-4-6-20/h2-10H,11-18H2,1H3,(H2,28,29,35)
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n/an/a 102n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222548
PNG
(US9315491, MTR-0124)
Show SMILES CCOc1c(nc(nc1C(=O)N1CCOCC1)-c1ccc(NC(=O)Nc2ccccc2)cc1)N1CCOCC1
Show InChI InChI=1S/C28H32N6O5/c1-2-39-24-23(27(35)34-14-18-38-19-15-34)31-25(32-26(24)33-12-16-37-17-13-33)20-8-10-22(11-9-20)30-28(36)29-21-6-4-3-5-7-21/h3-11H,2,12-19H2,1H3,(H2,29,30,36)
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n/an/a 103n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222575
PNG
(US9315491, MTR-0231)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C31H39N7O5/c1-4-42-27-26(30(39)43-5-2)34-28(35-29(27)38-18-20-41-21-19-38)22-6-8-23(9-7-22)32-31(40)33-24-10-12-25(13-11-24)37-16-14-36(3)15-17-37/h6-13H,4-5,14-21H2,1-3H3,(H2,32,33,40)
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n/an/a 105n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222598
PNG
(US9315491, MTR-0274)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C32H39N7O6/c1-4-44-27-26(31(41)45-5-2)35-28(36-29(27)38-18-20-43-21-19-38)22-6-10-24(11-7-22)33-32(42)34-25-12-8-23(9-13-25)30(40)39-16-14-37(3)15-17-39/h6-13H,4-5,14-21H2,1-3H3,(H2,33,34,42)
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n/an/a 106n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222581
PNG
(US9315491, MTR-0242)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(N3CCOCC3)c(F)c2)cc1
Show InChI InChI=1S/C26H29FN6O4/c1-35-23-17-28-24(31-25(23)33-10-14-37-15-11-33)18-2-4-19(5-3-18)29-26(34)30-20-6-7-22(21(27)16-20)32-8-12-36-13-9-32/h2-7,16-17H,8-15H2,1H3,(H2,29,30,34)
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n/an/a 107n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222547
PNG
(US9315491, MTR-0083)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(N)=O)cc1
Show InChI InChI=1S/C16H18ClN5O2S/c1-25-12-13(17)20-14(21-15(12)22-6-8-24-9-7-22)10-2-4-11(5-3-10)19-16(18)23/h2-5H,6-9H2,1H3,(H3,18,19,23)
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n/an/a 107n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222594
PNG
(US9315491, MTR-0267)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)cc1
Show InChI InChI=1S/C23H24N6O3S/c1-33-19-14-25-21(28-22(19)29-10-12-32-13-11-29)16-4-8-18(9-5-16)27-23(31)26-17-6-2-15(3-7-17)20(24)30/h2-9,14H,10-13H2,1H3,(H2,24,30)(H2,26,27,31)
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n/an/a 109n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222560
PNG
(US9315491, MTR-0197)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2cccnc2)cc1
Show InChI InChI=1S/C21H21ClN6O2S/c1-31-17-18(22)26-19(27-20(17)28-9-11-30-12-10-28)14-4-6-15(7-5-14)24-21(29)25-16-3-2-8-23-13-16/h2-8,13H,9-12H2,1H3,(H2,24,25,29)
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n/an/a 110n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222654
PNG
(US9315491, MTR-0454)
Show SMILES O=C(Nc1ccc(cc1)C(=O)N1CCOCC1)Nc1ccc(cc1)-c1ncc(OCCN2CCOCC2)c(n1)N1CCOCC1
Show InChI InChI=1S/C32H39N7O6/c40-31(39-14-20-44-21-15-39)25-3-7-27(8-4-25)35-32(41)34-26-5-1-24(2-6-26)29-33-23-28(30(36-29)38-12-18-43-19-13-38)45-22-11-37-9-16-42-17-10-37/h1-8,23H,9-22H2,(H2,34,35,41)
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n/an/a 111n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222550
PNG
(US9315491, MTR-0132)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(Cl)c(SC)c(n1)N1CCOCC1
Show InChI InChI=1S/C18H22ClN5O2S/c1-3-20-18(25)21-13-6-4-12(5-7-13)16-22-15(19)14(27-2)17(23-16)24-8-10-26-11-9-24/h4-7H,3,8-11H2,1-2H3,(H2,20,21,25)
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n/an/a 116n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222559
PNG
(US9315491, MTR-0195)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(Cl)c(SC)c(n1)N1CCOCC1
Show InChI InChI=1S/C17H20ClN5O2S/c1-19-17(24)20-12-5-3-11(4-6-12)15-21-14(18)13(26-2)16(22-15)23-7-9-25-10-8-23/h3-6H,7-10H2,1-2H3,(H2,19,20,24)
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n/an/a 116n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222563
PNG
(US9315491, MTR-0205)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2cccnc2)cc1
Show InChI InChI=1S/C25H28N6O5/c1-3-35-21-20(24(32)36-4-2)29-22(30-23(21)31-12-14-34-15-13-31)17-7-9-18(10-8-17)27-25(33)28-19-6-5-11-26-16-19/h5-11,16H,3-4,12-15H2,1-2H3,(H2,27,28,33)
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n/an/a 116n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222585
PNG
(US9315491, MTR-0249)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2nccs2)cc1
Show InChI InChI=1S/C19H20N6O2S2/c1-28-15-12-21-16(23-17(15)25-7-9-27-10-8-25)13-2-4-14(5-3-13)22-18(26)24-19-20-6-11-29-19/h2-6,11-12H,7-10H2,1H3,(H2,20,22,24,26)
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n/an/a 117n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222665
PNG
(US9315491, MTR-0472)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccncc2)cc1
Show InChI InChI=1S/C21H22N6O3/c1-29-18-14-23-19(26-20(18)27-10-12-30-13-11-27)15-2-4-16(5-3-15)24-21(28)25-17-6-8-22-9-7-17/h2-9,14H,10-13H2,1H3,(H2,22,24,25,28)
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n/an/a 117n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222656
PNG
(US9315491, MTR-0456)
Show SMILES NC(=O)c1ccc(NC(=O)Nc2ccc(cc2)-c2ncc(OCCN3CCOCC3)c(n2)N2CCOCC2)cc1
Show InChI InChI=1S/C28H33N7O5/c29-25(36)20-1-5-22(6-2-20)31-28(37)32-23-7-3-21(4-8-23)26-30-19-24(27(33-26)35-12-16-39-17-13-35)40-18-11-34-9-14-38-15-10-34/h1-8,19H,9-18H2,(H2,29,36)(H2,31,32,37)
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n/an/a 119n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222662
PNG
(US9315491, MTR-0465)
Show SMILES CSc1c(nc(nc1-c1ccncc1)-c1ccc(NC(=O)Nc2ccccc2)cc1)N1CCOCC1
Show InChI InChI=1S/C27H26N6O2S/c1-36-24-23(19-11-13-28-14-12-19)31-25(32-26(24)33-15-17-35-18-16-33)20-7-9-22(10-8-20)30-27(34)29-21-5-3-2-4-6-21/h2-14H,15-18H2,1H3,(H2,29,30,34)
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n/an/a 124n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222625
PNG
(US9315491, MTR-0376)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(NS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C23H26N6O4S2/c1-34-20-15-24-21(27-22(20)29-11-13-33-14-12-29)16-3-5-17(6-4-16)25-23(30)26-18-7-9-19(10-8-18)28-35(2,31)32/h3-10,15,28H,11-14H2,1-2H3,(H2,25,26,30)
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n/an/a 130n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222626
PNG
(US9315491, MTR-0378)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1F
Show InChI InChI=1S/C26H27FN6O4S/c1-38-22-15-28-24(31-25(22)32-8-11-36-12-9-32)20-7-4-18(14-21(20)27)30-26(35)29-17-2-5-19(6-3-17)33-10-13-37-16-23(33)34/h2-7,14-15H,8-13,16H2,1H3,(H2,29,30,35)
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n/an/a 133n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222566
PNG
(US9315491, MTR-0216)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCSCC2)cc1
Show InChI InChI=1S/C26H29ClN6O2S2/c1-36-22-23(27)30-24(31-25(22)33-10-14-35-15-11-33)18-2-4-19(5-3-18)28-26(34)29-20-6-8-21(9-7-20)32-12-16-37-17-13-32/h2-9H,10-17H2,1H3,(H2,28,29,34)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222568
PNG
(US9315491, MTR-0221)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(N3CCOCC3)c(F)c2)cc1
Show InChI InChI=1S/C30H35FN6O6/c1-3-42-26-25(29(38)43-4-2)34-27(35-28(26)37-13-17-41-18-14-37)20-5-7-21(8-6-20)32-30(39)33-22-9-10-24(23(31)19-22)36-11-15-40-16-12-36/h5-10,19H,3-4,11-18H2,1-2H3,(H2,32,33,39)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222640
PNG
(US9315491, MTR-0412)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1F
Show InChI InChI=1S/C22H22ClFN6O4S2/c1-35-18-19(23)28-20(29-21(18)30-8-10-34-11-9-30)16-7-4-14(12-17(16)24)27-22(31)26-13-2-5-15(6-3-13)36(25,32)33/h2-7,12H,8-11H2,1H3,(H2,25,32,33)(H2,26,27,31)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222658
PNG
(US9315491, MTR-0461)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C27H30N6O4S/c1-38-23-18-28-24(31-25(23)32-10-14-36-15-11-32)19-2-6-21(7-3-19)29-27(35)30-22-8-4-20(5-9-22)26(34)33-12-16-37-17-13-33/h2-9,18H,10-17H2,1H3,(H2,29,30,35)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222630
PNG
(US9315491, MTR-0387)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C23H24ClN5O4S2/c1-34-19-20(24)27-21(28-22(19)29-11-13-33-14-12-29)15-3-5-16(6-4-15)25-23(30)26-17-7-9-18(10-8-17)35(2,31)32/h3-10H,11-14H2,1-2H3,(H2,25,26,30)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222545
PNG
(US9315491, MTR-0069)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C26H29N5O5/c1-3-35-22-21(25(32)36-4-2)29-23(30-24(22)31-14-16-34-17-15-31)18-10-12-20(13-11-18)28-26(33)27-19-8-6-5-7-9-19/h5-13H,3-4,14-17H2,1-2H3,(H2,27,28,33)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222587
PNG
(US9315491, MTR-0251)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2cccc(c2)C(N)=O)cc1
Show InChI InChI=1S/C27H30N6O6/c1-3-38-22-21(26(35)39-4-2)31-24(32-25(22)33-12-14-37-15-13-33)17-8-10-19(11-9-17)29-27(36)30-20-7-5-6-18(16-20)23(28)34/h5-11,16H,3-4,12-15H2,1-2H3,(H2,28,34)(H2,29,30,36)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222636
PNG
(US9315491, MTR-0404)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C23H25N5O4S2/c1-33-20-15-24-21(27-22(20)28-11-13-32-14-12-28)16-3-5-17(6-4-16)25-23(29)26-18-7-9-19(10-8-18)34(2,30)31/h3-10,15H,11-14H2,1-2H3,(H2,25,26,29)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222586
PNG
(US9315491, MTR-0250)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2cccc(NC(C)=O)c2)cc1
Show InChI InChI=1S/C28H32N6O6/c1-4-39-24-23(27(36)40-5-2)32-25(33-26(24)34-13-15-38-16-14-34)19-9-11-20(12-10-19)30-28(37)31-22-8-6-7-21(17-22)29-18(3)35/h6-12,17H,4-5,13-16H2,1-3H3,(H,29,35)(H2,30,31,37)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222652
PNG
(US9315491, MTR-0452)
Show SMILES CCOc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C27H32N6O6S/c1-2-39-24-19-28-25(31-26(24)32-11-15-37-16-12-32)20-3-5-21(6-4-20)29-27(34)30-22-7-9-23(10-8-22)40(35,36)33-13-17-38-18-14-33/h3-10,19H,2,11-18H2,1H3,(H2,29,30,34)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222561
PNG
(US9315491, MTR-0199)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(OCCN(C)C)cc2)cc1
Show InChI InChI=1S/C26H31ClN6O3S/c1-32(2)12-17-36-21-10-8-20(9-11-21)29-26(34)28-19-6-4-18(5-7-19)24-30-23(27)22(37-3)25(31-24)33-13-15-35-16-14-33/h4-11H,12-17H2,1-3H3,(H2,28,29,34)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222669
PNG
(US9315491, MTR-0481)
Show SMILES O=C(Nc1ccncc1)Nc1ccc(cc1)-c1ncc(OCCN2CCOCC2)c(n1)N1CCOCC1
Show InChI InChI=1S/C26H31N7O4/c34-26(30-22-5-7-27-8-6-22)29-21-3-1-20(2-4-21)24-28-19-23(25(31-24)33-12-16-36-17-13-33)37-18-11-32-9-14-35-15-10-32/h1-8,19H,9-18H2,(H2,27,29,30,34)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222608
PNG
(US9315491, MTR-0314)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2nccs2)cc1
Show InChI InChI=1S/C19H20N6O3S/c1-27-15-12-21-16(23-17(15)25-7-9-28-10-8-25)13-2-4-14(5-3-13)22-18(26)24-19-20-6-11-29-19/h2-6,11-12H,7-10H2,1H3,(H2,20,22,24,26)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222592
PNG
(US9315491, MTR-0265)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(nc2)N2CCOCC2)cc1
Show InChI InChI=1S/C25H29N7O3S/c1-36-21-17-27-23(30-24(21)32-10-14-35-15-11-32)18-2-4-19(5-3-18)28-25(33)29-20-6-7-22(26-16-20)31-8-12-34-13-9-31/h2-7,16-17H,8-15H2,1H3,(H2,28,29,33)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222644
PNG
(US9315491, MTR-0426)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2cccc(NC(C)=O)c2)cc1
Show InChI InChI=1S/C24H26N6O4/c1-16(31)26-19-4-3-5-20(14-19)28-24(32)27-18-8-6-17(7-9-18)22-25-15-21(33-2)23(29-22)30-10-12-34-13-11-30/h3-9,14-15H,10-13H2,1-2H3,(H,26,31)(H2,27,28,32)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222615
PNG
(US9315491, MTR-0347)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(NS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C23H25ClN6O4S2/c1-35-19-20(24)27-21(28-22(19)30-11-13-34-14-12-30)15-3-5-16(6-4-15)25-23(31)26-17-7-9-18(10-8-17)29-36(2,32)33/h3-10,29H,11-14H2,1-2H3,(H2,25,26,31)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222666
PNG
(US9315491, MTR-0476)
Show SMILES COc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccncc2)cc1
Show InChI InChI=1S/C21H21ClN6O3/c1-30-17-18(22)26-19(27-20(17)28-10-12-31-13-11-28)14-2-4-15(5-3-14)24-21(29)25-16-6-8-23-9-7-16/h2-9H,10-13H2,1H3,(H2,23,24,25,29)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222604
PNG
(US9315491, MTR-0299)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc3oc(=O)[nH]c3c2)cc1
Show InChI InChI=1S/C27H28N6O7/c1-3-38-22-21(25(34)39-4-2)31-23(32-24(22)33-11-13-37-14-12-33)16-5-7-17(8-6-16)28-26(35)29-18-9-10-20-19(15-18)30-27(36)40-20/h5-10,15H,3-4,11-14H2,1-2H3,(H,30,36)(H2,28,29,35)
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n/an/a 177n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222638
PNG
(US9315491, MTR-0406)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1F
Show InChI InChI=1S/C26H27FN6O5/c1-36-22-15-28-24(31-25(22)32-8-11-37-12-9-32)20-7-4-18(14-21(20)27)30-26(35)29-17-2-5-19(6-3-17)33-10-13-38-16-23(33)34/h2-7,14-15H,8-13,16H2,1H3,(H2,29,30,35)
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n/an/a 180n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222620
PNG
(US9315491, MTR-0365)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C27H31N5O7S/c1-4-38-23-22(26(33)39-5-2)30-24(31-25(23)32-14-16-37-17-15-32)18-6-8-19(9-7-18)28-27(34)29-20-10-12-21(13-11-20)40(3,35)36/h6-13H,4-5,14-17H2,1-3H3,(H2,28,29,34)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222576
PNG
(US9315491, MTR-0232)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCSCC2)cc1
Show InChI InChI=1S/C30H36N6O5S/c1-3-40-26-25(29(37)41-4-2)33-27(34-28(26)36-13-17-39-18-14-36)21-5-7-22(8-6-21)31-30(38)32-23-9-11-24(12-10-23)35-15-19-42-20-16-35/h5-12H,3-4,13-20H2,1-2H3,(H2,31,32,38)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222663
PNG
(US9315491, MTR-0469)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccncc2)cc1
Show InChI InChI=1S/C21H21ClN6O2S/c1-31-17-18(22)26-19(27-20(17)28-10-12-30-13-11-28)14-2-4-15(5-3-14)24-21(29)25-16-6-8-23-9-7-16/h2-9H,10-13H2,1H3,(H2,23,24,25,29)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222617
PNG
(US9315491, MTR-0353)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(nc2)N2CCOCC2)cc1
Show InChI InChI=1S/C25H29N7O4/c1-34-21-17-27-23(30-24(21)32-10-14-36-15-11-32)18-2-4-19(5-3-18)28-25(33)29-20-6-7-22(26-16-20)31-8-12-35-13-9-31/h2-7,16-17H,8-15H2,1H3,(H2,28,29,33)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222554
PNG
(US9315491, MTR-0173)
Show SMILES CSc1c(nc(nc1N1CCN(CC1)S(C)(=O)=O)-c1ccc(NC(=O)Nc2ccccc2)cc1)N1CCOCC1
Show InChI InChI=1S/C27H33N7O4S2/c1-39-23-25(32-12-14-34(15-13-32)40(2,36)37)30-24(31-26(23)33-16-18-38-19-17-33)20-8-10-22(11-9-20)29-27(35)28-21-6-4-3-5-7-21/h3-11H,12-19H2,1-2H3,(H2,28,29,35)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222624
PNG
(US9315491, MTR-0372)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc3oc(=O)[nH]c3c2)cc1
Show InChI InChI=1S/C23H21ClN6O4S/c1-35-18-19(24)28-20(29-21(18)30-8-10-33-11-9-30)13-2-4-14(5-3-13)25-22(31)26-15-6-7-17-16(12-15)27-23(32)34-17/h2-7,12H,8-11H2,1H3,(H,27,32)(H2,25,26,31)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222552
PNG
(US9315491, MTR-0152)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(F)cc2)cc1
Show InChI InChI=1S/C22H22FN5O3/c1-30-19-14-24-20(27-21(19)28-10-12-31-13-11-28)15-2-6-17(7-3-15)25-22(29)26-18-8-4-16(23)5-9-18/h2-9,14H,10-13H2,1H3,(H2,25,26,29)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222555
PNG
(US9315491, MTR-0176)
Show SMILES CCOc1c(CN2CCOCC2)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C28H34N6O4/c1-2-38-25-24(20-33-12-16-36-17-13-33)31-26(32-27(25)34-14-18-37-19-15-34)21-8-10-23(11-9-21)30-28(35)29-22-6-4-3-5-7-22/h3-11H,2,12-20H2,1H3,(H2,29,30,35)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222571
PNG
(US9315491, MTR-0226)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(N3CCOCC3)c(F)c2)cc1
Show InChI InChI=1S/C26H29FN6O3S/c1-37-23-17-28-24(31-25(23)33-10-14-36-15-11-33)18-2-4-19(5-3-18)29-26(34)30-20-6-7-22(21(27)16-20)32-8-12-35-13-9-32/h2-7,16-17H,8-15H2,1H3,(H2,29,30,34)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222622
PNG
(US9315491, MTR-0369)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)Nc2ccc(NS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C27H32N6O7S/c1-4-39-23-22(26(34)40-5-2)30-24(31-25(23)33-14-16-38-17-15-33)18-6-8-19(9-7-18)28-27(35)29-20-10-12-21(13-11-20)32-41(3,36)37/h6-13,32H,4-5,14-17H2,1-3H3,(H2,28,29,35)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222607
PNG
(US9315491, MTR-0313)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2cccc(c2)C(N)=O)cc1
Show InChI InChI=1S/C23H24N6O4/c1-32-19-14-25-21(28-22(19)29-9-11-33-12-10-29)15-5-7-17(8-6-15)26-23(31)27-18-4-2-3-16(13-18)20(24)30/h2-8,13-14H,9-12H2,1H3,(H2,24,30)(H2,26,27,31)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222629
PNG
(US9315491, MTR-0385)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)c(F)c1
Show InChI InChI=1S/C23H23FN6O4/c1-33-19-13-26-21(29-22(19)30-8-10-34-11-9-30)15-4-7-18(17(24)12-15)28-23(32)27-16-5-2-14(3-6-16)20(25)31/h2-7,12-13H,8-11H2,1H3,(H2,25,31)(H2,27,28,32)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222639
PNG
(US9315491, MTR-0407)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)cc1F
Show InChI InChI=1S/C23H23FN6O4/c1-33-19-13-26-21(29-22(19)30-8-10-34-11-9-30)17-7-6-16(12-18(17)24)28-23(32)27-15-4-2-14(3-5-15)20(25)31/h2-7,12-13H,8-11H2,1H3,(H2,25,31)(H2,27,28,32)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222627
PNG
(US9315491, MTR-0380)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(NC(C)=O)cc2)cc1
Show InChI InChI=1S/C24H26N6O3S/c1-16(31)26-18-7-9-20(10-8-18)28-24(32)27-19-5-3-17(4-6-19)22-25-15-21(34-2)23(29-22)30-11-13-33-14-12-30/h3-10,15H,11-14H2,1-2H3,(H,26,31)(H2,27,28,32)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222558
PNG
(US9315491, MTR-0185)
Show SMILES COc1c(nc(nc1C(=O)N1CCN(CC1)S(C)(=O)=O)-c1ccc(NC(=O)Nc2ccccc2)cc1)N1CCOCC1
Show InChI InChI=1S/C28H33N7O6S/c1-40-24-23(27(36)34-12-14-35(15-13-34)42(2,38)39)31-25(32-26(24)33-16-18-41-19-17-33)20-8-10-22(11-9-20)30-28(37)29-21-6-4-3-5-7-21/h3-11H,12-19H2,1-2H3,(H2,29,30,37)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222579
PNG
(US9315491, MTR-0238)
Show SMILES CSc1c(nc(nc1N1CCN(C)CC1)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CCOCC1
Show InChI InChI=1S/C26H32N8O2S/c1-32-10-12-33(13-11-32)24-22(37-2)25(34-14-16-36-17-15-34)31-23(30-24)19-5-7-20(8-6-19)28-26(35)29-21-4-3-9-27-18-21/h3-9,18H,10-17H2,1-2H3,(H2,28,29,35)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222564
PNG
(US9315491, MTR-0211)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(N3CCOCC3)c(F)c2)cc1
Show InChI InChI=1S/C26H28ClFN6O3S/c1-38-22-23(27)31-24(32-25(22)34-10-14-37-15-11-34)17-2-4-18(5-3-17)29-26(35)30-19-6-7-21(20(28)16-19)33-8-12-36-13-9-33/h2-7,16H,8-15H2,1H3,(H2,29,30,35)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222583
PNG
(US9315491, MTR-0246)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C27H33N7O2S/c1-32-11-13-33(14-12-32)23-9-7-22(8-10-23)30-27(35)29-21-5-3-20(4-6-21)25-28-19-24(37-2)26(31-25)34-15-17-36-18-16-34/h3-10,19H,11-18H2,1-2H3,(H2,29,30,35)
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n/an/a 228n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222553
PNG
(US9315491, MTR-0165)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(F)c(F)c2)cc1
Show InChI InChI=1S/C22H21F2N5O3/c1-31-19-13-25-20(28-21(19)29-8-10-32-11-9-29)14-2-4-15(5-3-14)26-22(30)27-16-6-7-17(23)18(24)12-16/h2-7,12-13H,8-11H2,1H3,(H2,26,27,30)
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n/an/a 233n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222595
PNG
(US9315491, MTR-0268)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cn2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C26H31ClN8O2S/c1-33-9-11-34(12-10-33)20-7-8-21(28-17-20)30-26(36)29-19-5-3-18(4-6-19)24-31-23(27)22(38-2)25(32-24)35-13-15-37-16-14-35/h3-8,17H,9-16H2,1-2H3,(H2,28,29,30,36)
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n/an/a 238n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222605
PNG
(US9315491, MTR-0303)
Show SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=S)Nc2cccnc2)cc1
Show InChI InChI=1S/C21H21ClN6OS2/c1-31-17-18(22)26-19(27-20(17)28-9-11-29-12-10-28)14-4-6-15(7-5-14)24-21(30)25-16-3-2-8-23-13-16/h2-8,13H,9-12H2,1H3,(H2,24,25,30)
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n/an/a 238n/an/an/an/an/an/a



DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222574
PNG
(US9315491, MTR-0229)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1ncc(OC)c(n1)N1CCOCC1
Show InChI InChI=1S/C17H21N5O3/c1-18-17(23)20-13-5-3-12(4-6-13)15-19-11-14(24-2)16(21-15)22-7-9-25-10-8-22/h3-6,11H,7-10H2,1-2H3,(H2,18,20,23)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222664
PNG
(US9315491, MTR-0471)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C26H30N6O6S/c1-36-23-18-27-24(30-25(23)31-10-14-37-15-11-31)19-2-4-20(5-3-19)28-26(33)29-21-6-8-22(9-7-21)39(34,35)32-12-16-38-17-13-32/h2-9,18H,10-17H2,1H3,(H2,28,29,33)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222549
PNG
(US9315491, MTR-0128)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C22H23N5O3/c1-29-19-15-23-20(26-21(19)27-11-13-30-14-12-27)16-7-9-18(10-8-16)25-22(28)24-17-5-3-2-4-6-17/h2-10,15H,11-14H2,1H3,(H2,24,25,28)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222562
PNG
(US9315491, MTR-0202)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OCC)-c1ccc(NC(=O)NC)cc1
Show InChI InChI=1S/C21H27N5O5/c1-4-30-17-16(20(27)31-5-2)24-18(25-19(17)26-10-12-29-13-11-26)14-6-8-15(9-7-14)23-21(28)22-3/h6-9H,4-5,10-13H2,1-3H3,(H2,22,23,28)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222672
PNG
(US9315491, MTR-0488)
Show SMILES CCOc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccncc2)cc1
Show InChI InChI=1S/C22H23ClN6O3/c1-2-32-18-19(23)27-20(28-21(18)29-11-13-31-14-12-29)15-3-5-16(6-4-15)25-22(30)26-17-7-9-24-10-8-17/h3-10H,2,11-14H2,1H3,(H2,24,25,26,30)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222593
PNG
(US9315491, MTR-0266)
Show SMILES CSc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(nc2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C26H32N8O2S/c1-32-9-11-33(12-10-32)23-8-7-21(17-27-23)30-26(35)29-20-5-3-19(4-6-20)24-28-18-22(37-2)25(31-24)34-13-15-36-16-14-34/h3-8,17-18H,9-16H2,1-2H3,(H2,29,30,35)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222551
PNG
(US9315491, MTR-0142)
Show SMILES CCOc1c(nc(nc1C(=O)N1CCCCC1)-c1ccc(NC(=O)Nc2ccccc2)cc1)N1CCOCC1
Show InChI InChI=1S/C29H34N6O4/c1-2-39-25-24(28(36)35-15-7-4-8-16-35)32-26(33-27(25)34-17-19-38-20-18-34)21-11-13-23(14-12-21)31-29(37)30-22-9-5-3-6-10-22/h3,5-6,9-14H,2,4,7-8,15-20H2,1H3,(H2,30,31,37)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222673
PNG
(US9315491, MTR-0489)
Show SMILES CCOc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2cccnc2)cc1
Show InChI InChI=1S/C22H23ClN6O3/c1-2-32-18-19(23)27-20(28-21(18)29-10-12-31-13-11-29)15-5-7-16(8-6-15)25-22(30)26-17-4-3-9-24-14-17/h3-9,14H,2,10-13H2,1H3,(H2,25,26,30)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222614
PNG
(US9315491, MTR-0337)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C27H33N7O3/c1-32-11-13-33(14-12-32)23-9-7-22(8-10-23)30-27(35)29-21-5-3-20(4-6-21)25-28-19-24(36-2)26(31-25)34-15-17-37-18-16-34/h3-10,19H,11-18H2,1-2H3,(H2,29,30,35)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222556
PNG
(US9315491, MTR-0182)
Show SMILES CCOC(=O)c1nc(nc(N2CCOCC2)c1OC)-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C25H27N5O5/c1-3-35-24(31)20-21(33-2)23(30-13-15-34-16-14-30)29-22(28-20)17-9-11-19(12-10-17)27-25(32)26-18-7-5-4-6-8-18/h4-12H,3,13-16H2,1-2H3,(H2,26,27,32)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM222546
PNG
(US9315491, MTR-0081)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c(OCC)c(n1)C(=O)OCC
Show InChI InChI=1S/C22H29N5O5/c1-4-23-22(29)24-16-9-7-15(8-10-16)19-25-17(21(28)32-6-3)18(31-5-2)20(26-19)27-11-13-30-14-12-27/h7-10H,4-6,11-14H2,1-3H3,(H2,23,24,29)
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DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC

US Patent


Assay Description
The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%