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Patent code US9315498

Compile Data Set for Download or QSAR
Found 174 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222718
PNG
(US9315498, 5)
Show SMILES CC1(C)CN(C(=O)O1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H16N2O2/c1-18(2)13-20(17(21)22-18)16-11-10-15(12-19-16)9-8-14-6-4-3-5-7-14/h3-7,10-12H,13H2,1-2H3
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n/an/an/an/a 7n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222719
PNG
(US9315498, 6)
Show SMILES CC1(C)CN(C(=O)O1)c1ccc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C18H15FN2O2/c1-18(2)12-21(17(22)23-18)16-9-8-14(11-20-16)7-6-13-4-3-5-15(19)10-13/h3-5,8-11H,12H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222724
PNG
(US9315498, 11)
Show SMILES O=C1OC2(CCCC2)CN1c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H18N2O2/c23-19-22(15-20(24-19)12-4-5-13-20)18-11-10-17(14-21-18)9-8-16-6-2-1-3-7-16/h1-3,6-7,10-11,14H,4-5,12-13,15H2
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222727
PNG
(US9315498, 14)
Show SMILES CC1(C)CN(C(=O)C1O)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H18N2O2/c1-19(2)13-21(18(23)17(19)22)16-11-10-15(12-20-16)9-8-14-6-4-3-5-7-14/h3-7,10-12,17,22H,13H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222728
PNG
(US9315498, 15)
Show SMILES CC1(C)CN(C(=O)N1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H17N3O/c1-18(2)13-21(17(22)20-18)16-11-10-15(12-19-16)9-8-14-6-4-3-5-7-14/h3-7,10-12H,13H2,1-2H3,(H,20,22)
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222729
PNG
(US9315498, 16)
Show SMILES CN1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H19N3O/c1-19(2)14-22(18(23)21(19)3)17-12-11-16(13-20-17)10-9-15-7-5-4-6-8-15/h4-8,11-13H,14H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222747
PNG
(US9315498, 35)
Show SMILES CC1(C)CN(C(=O)O1)c1ccc(cn1)C#Cc1ccc(F)nc1
Show InChI InChI=1S/C17H14FN3O2/c1-17(2)11-21(16(22)23-17)15-8-6-13(10-20-15)4-3-12-5-7-14(18)19-9-12/h5-10H,11H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222772
PNG
(US9315498, 60)
Show SMILES COC1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H20N2O2/c1-20(2)14-22(19(23)18(20)24-3)17-12-11-16(13-21-17)10-9-15-7-5-4-6-8-15/h4-8,11-13,18H,14H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222781
PNG
(US9315498, 67)
Show SMILES CN1C(=O)N(CCC1(C)C)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H21N3O/c1-20(2)13-14-23(19(24)22(20)3)18-12-11-17(15-21-18)10-9-16-7-5-4-6-8-16/h4-8,11-12,15H,13-14H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222783
PNG
(US9315498, 69)
Show SMILES CN1C(=O)N(CCC1(C)C)c1ccc(cn1)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3O/c1-20(2)12-13-24(19(25)23(20)3)18-11-8-16(14-22-18)5-4-15-6-9-17(21)10-7-15/h6-11,14H,12-13H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222790
PNG
(US9315498, 78)
Show SMILES Cc1cccc(c1)C#Cc1ccc(nc1)N1CCC(C)(C)OC1=O
Show InChI InChI=1S/C20H20N2O2/c1-15-5-4-6-16(13-15)7-8-17-9-10-18(21-14-17)22-12-11-20(2,3)24-19(22)23/h4-6,9-10,13-14H,11-12H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222800
PNG
(US9315498, 90)
Show SMILES CC1(C)CCN(C(=O)C1)c1ccc(cn1)C#Cc1cncc(Cl)c1
Show InChI InChI=1S/C19H18ClN3O/c1-19(2)7-8-23(18(24)10-19)17-6-5-14(12-22-17)3-4-15-9-16(20)13-21-11-15/h5-6,9,11-13H,7-8,10H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222805
PNG
(US9315498, 95)
Show SMILES CC1(C)OC(=O)N(CC1O)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H18N2O3/c1-19(2)16(22)13-21(18(23)24-19)17-11-10-15(12-20-17)9-8-14-6-4-3-5-7-14/h3-7,10-12,16,22H,13H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222812
PNG
(US9315498, 102)
Show SMILES O=C1O[C@H]2CCC[C@@H]2CN1c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H18N2O2/c23-20-22(14-17-7-4-8-18(17)24-20)19-12-11-16(13-21-19)10-9-15-5-2-1-3-6-15/h1-3,5-6,11-13,17-18H,4,7-8,14H2/t17-,18+/m1/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222813
PNG
(US9315498, 104)
Show SMILES CC1CN(C(=O)OC1(C)C)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H20N2O2/c1-15-14-22(19(23)24-20(15,2)3)18-12-11-17(13-21-18)10-9-16-7-5-4-6-8-16/h4-8,11-13,15H,14H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222835
PNG
(US9315498, 126)
Show SMILES CN1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1ccc(F)c(F)c1
Show InChI InChI=1S/C18H16F2N4O/c1-18(2)11-24(17(25)23(18)3)16-21-9-13(10-22-16)5-4-12-6-7-14(19)15(20)8-12/h6-10H,11H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222848
PNG
(US9315498, 134)
Show SMILES CC1(C)CCN(C(=O)C1)c1ncc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H19N3O/c1-19(2)10-11-22(17(23)12-19)18-20-13-16(14-21-18)9-8-15-6-4-3-5-7-15/h3-7,13-14H,10-12H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222855
PNG
(US9315498, 141)
Show SMILES CC(C)N1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C20H21FN4O/c1-14(2)25-19(26)24(13-20(25,3)4)18-22-11-16(12-23-18)9-8-15-6-5-7-17(21)10-15/h5-7,10-12,14H,13H2,1-4H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222858
PNG
(US9315498, 144)
Show SMILES CCN1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C19H19FN4O/c1-4-24-18(25)23(13-19(24,2)3)17-21-11-15(12-22-17)9-8-14-6-5-7-16(20)10-14/h5-7,10-12H,4,13H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222865
PNG
(US9315498, 151)
Show SMILES CC1(C)CCN(C(=O)C1)c1ccc(nn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H19N3O/c1-19(2)12-13-22(18(23)14-19)17-11-10-16(20-21-17)9-8-15-6-4-3-5-7-15/h3-7,10-11H,12-14H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222869
PNG
(US9315498, 155)
Show SMILES CN1C(=O)N(CC1(C)C)c1ccc(nn1)C#Cc1cccc(Cl)c1
Show InChI InChI=1S/C18H17ClN4O/c1-18(2)12-23(17(24)22(18)3)16-10-9-15(20-21-16)8-7-13-5-4-6-14(19)11-13/h4-6,9-11H,12H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222874
PNG
(US9315498, 160)
Show SMILES CC1(C)CN(C(=O)C1)c1cnc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C18H16FN3O/c1-18(2)9-17(23)22(12-18)16-11-20-15(10-21-16)7-6-13-4-3-5-14(19)8-13/h3-5,8,10-11H,9,12H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222877
PNG
(US9315498, 163)
Show SMILES CC1(C)CCN(C(=O)C1)c1cnc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H19N3O/c1-19(2)10-11-22(18(23)12-19)17-14-20-16(13-21-17)9-8-15-6-4-3-5-7-15/h3-7,13-14H,10-12H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222878
PNG
(US9315498, 164)
Show SMILES CC1(C)CCN(C(=O)N1)c1cnc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H18N4O/c1-18(2)10-11-22(17(23)21-18)16-13-19-15(12-20-16)9-8-14-6-4-3-5-7-14/h3-7,12-13H,10-11H2,1-2H3,(H,21,23)
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222886
PNG
(US9315498, 172)
Show SMILES CC1(C)CN(C(=O)CO1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H18N2O2/c1-19(2)14-21(18(22)13-23-19)17-11-10-16(12-20-17)9-8-15-6-4-3-5-7-15/h3-7,10-12H,13-14H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222721
PNG
(US9315498, 8)
Show SMILES CC(C)(C)C1CN(C(=O)O1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H20N2O2/c1-20(2,3)17-14-22(19(23)24-17)18-12-11-16(13-21-18)10-9-15-7-5-4-6-8-15/h4-8,11-13,17H,14H2,1-3H3
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n/an/an/an/a 17n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222723
PNG
(US9315498, 10)
Show SMILES O=C1OC2(CCC2)CN1c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H16N2O2/c22-18-21(14-19(23-18)11-4-12-19)17-10-9-16(13-20-17)8-7-15-5-2-1-3-6-15/h1-3,5-6,9-10,13H,4,11-12,14H2
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222732
PNG
(US9315498, 19)
Show SMILES CC(C)(C)C1(C)CN(C(=O)O1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C21H22N2O2/c1-20(2,3)21(4)15-23(19(24)25-21)18-13-12-17(14-22-18)11-10-16-8-6-5-7-9-16/h5-9,12-14H,15H2,1-4H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222735
PNG
(US9315498, 23)
Show SMILES O=C1O[C@H]2CCC[C@H]2N1c1ccc(cn1)C#Cc1cccnc1
Show InChI InChI=1S/C18H15N3O2/c22-18-21(15-4-1-5-16(15)23-18)17-9-8-14(12-20-17)7-6-13-3-2-10-19-11-13/h2-3,8-12,15-16H,1,4-5H2/t15-,16+/m1/s1
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n/an/an/an/a 12n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222740
PNG
(US9315498, 28)
Show SMILES CC1(C)OC(=O)N(c2ccc(cn2)C#Cc2ccccc2)C1(C)C
Show InChI InChI=1S/C20H20N2O2/c1-19(2)20(3,4)24-18(23)22(19)17-13-12-16(14-21-17)11-10-15-8-6-5-7-9-15/h5-9,12-14H,1-4H3
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n/an/an/an/a 48n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222744
PNG
(US9315498, 32)
Show SMILES CC1(C)CN(C(=O)O1)c1ccc(cn1)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C18H15FN2O2/c1-18(2)12-21(17(22)23-18)16-10-7-14(11-20-16)4-3-13-5-8-15(19)9-6-13/h5-11H,12H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222745
PNG
(US9315498, 33)
Show SMILES CC1(C)CN(C(=O)O1)c1ccc(cn1)C#Cc1ccc(F)c(F)c1
Show InChI InChI=1S/C18H14F2N2O2/c1-18(2)11-22(17(23)24-18)16-8-6-13(10-21-16)4-3-12-5-7-14(19)15(20)9-12/h5-10H,11H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222751
PNG
(US9315498, 39)
Show SMILES CC1(C)CN(C(=O)C1)c1ccc(cn1)C#Cc1cncc(Cl)c1
Show InChI InChI=1S/C18H16ClN3O/c1-18(2)8-17(23)22(12-18)16-6-5-13(10-21-16)3-4-14-7-15(19)11-20-9-14/h5-7,9-11H,8,12H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222754
PNG
(US9315498, 42)
Show SMILES CC1(C)CCC(=O)N(C1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H20N2O/c1-20(2)13-12-19(23)22(15-20)18-11-10-17(14-21-18)9-8-16-6-4-3-5-7-16/h3-7,10-11,14H,12-13,15H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222758
PNG
(US9315498, 46)
Show SMILES O=C1[C@H]2CCC[C@H]2N1c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H16N2O/c22-19-16-7-4-8-17(16)21(19)18-12-11-15(13-20-18)10-9-14-5-2-1-3-6-14/h1-3,5-6,11-13,16-17H,4,7-8H2/t16-,17+/m0/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222761
PNG
(US9315498, 49)
Show SMILES CN1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1cncc(F)c1
Show InChI InChI=1S/C18H17FN4O/c1-18(2)12-23(17(24)22(18)3)16-7-6-13(10-21-16)4-5-14-8-15(19)11-20-9-14/h6-11H,12H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222765
PNG
(US9315498, 53)
Show SMILES CN1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C19H18FN3O/c1-19(2)13-23(18(24)22(19)3)17-10-9-15(12-21-17)8-7-14-5-4-6-16(20)11-14/h4-6,9-12H,13H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222767
PNG
(US9315498, 55)
Show SMILES CN1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1cncnc1
Show InChI InChI=1S/C17H17N5O/c1-17(2)11-22(16(23)21(17)3)15-7-6-13(10-20-15)4-5-14-8-18-12-19-9-14/h6-10,12H,11H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM198910
PNG
(US9221802, Ref. Ex. 72 | US9315498, 72)
Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H18N2O2/c1-19(2)12-13-21(18(22)23-19)17-11-10-16(14-20-17)9-8-15-6-4-3-5-7-15/h3-7,10-11,14H,12-13H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222792
PNG
(US9315498, 82)
Show SMILES O=C1CC2(COC2)CN1c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H16N2O2/c22-18-10-19(13-23-14-19)12-21(18)17-9-8-16(11-20-17)7-6-15-4-2-1-3-5-15/h1-5,8-9,11H,10,12-14H2
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222806
PNG
(US9315498, 96)
Show SMILES CN1C(=O)N(CC11CC1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H17N3O/c1-21-18(23)22(14-19(21)11-12-19)17-10-9-16(13-20-17)8-7-15-5-3-2-4-6-15/h2-6,9-10,13H,11-12,14H2,1H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222809
PNG
(US9315498, 99)
Show SMILES CCN1C2CCCCC2N(C1=O)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C22H23N3O/c1-2-24-19-10-6-7-11-20(19)25(22(24)26)21-15-14-18(16-23-21)13-12-17-8-4-3-5-9-17/h3-5,8-9,14-16,19-20H,2,6-7,10-11H2,1H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222815
PNG
(US9315498, 106)
Show SMILES CN1[C@H]2CCC[C@H]2N(C1=O)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H19N3O/c1-22-17-8-5-9-18(17)23(20(22)24)19-13-12-16(14-21-19)11-10-15-6-3-2-4-7-15/h2-4,6-7,12-14,17-18H,5,8-9H2,1H3/t17-,18+/m0/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222817
PNG
(US9315498, 108)
Show SMILES CN1C(=O)N(CC1(C)C)c1ncc(cc1C)C#Cc1cccc(F)c1
Show InChI InChI=1S/C20H20FN3O/c1-14-10-16(9-8-15-6-5-7-17(21)11-15)12-22-18(14)24-13-20(2,3)23(4)19(24)25/h5-7,10-12H,13H2,1-4H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222818
PNG
(US9315498, 109)
Show SMILES CN1[C@H]2CCC[C@H]2N(C1=O)c1ccc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C20H18FN3O/c1-23-17-6-3-7-18(17)24(20(23)25)19-11-10-15(13-22-19)9-8-14-4-2-5-16(21)12-14/h2,4-5,10-13,17-18H,3,6-7H2,1H3/t17-,18+/m0/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222833
PNG
(US9315498, 124)
Show SMILES CN1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1cc(F)ccc1F
Show InChI InChI=1S/C18H16F2N4O/c1-18(2)11-24(17(25)23(18)3)16-21-9-12(10-22-16)4-5-13-8-14(19)6-7-15(13)20/h6-10H,11H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222836
PNG
(US9315498, 127)
Show SMILES COC1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H19N3O2/c1-19(2)13-22(17(23)16(19)24-3)18-20-11-15(12-21-18)10-9-14-7-5-4-6-8-14/h4-8,11-12,16H,13H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222839
PNG
(US9315498, 129)
Show SMILES CO[C@@H]1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H19N3O2/c1-19(2)13-22(17(23)16(19)24-3)18-20-11-15(12-21-18)10-9-14-7-5-4-6-8-14/h4-8,11-12,16H,13H2,1-3H3/t16-/m1/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222842
PNG
(US9315498, 131)
Show SMILES CO[C@H]1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C19H18FN3O2/c1-19(2)12-23(17(24)16(19)25-3)18-21-10-14(11-22-18)8-7-13-5-4-6-15(20)9-13/h4-6,9-11,16H,12H2,1-3H3/t16-/m0/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222867
PNG
(US9315498, 153)
Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(nn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H17N3O2/c1-18(2)12-13-21(17(22)23-18)16-11-10-15(19-20-16)9-8-14-6-4-3-5-7-14/h3-7,10-11H,12-13H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222884
PNG
(US9315498, 170)
Show SMILES CN1[C@H]2CCC[C@H]2N(C1=O)c1ccc(nn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H18N4O/c1-22-16-8-5-9-17(16)23(19(22)24)18-13-12-15(20-21-18)11-10-14-6-3-2-4-7-14/h2-4,6-7,12-13,16-17H,5,8-9H2,1H3/t16-,17+/m0/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222713
PNG
(US9315498, 2)
Show SMILES COCC1CN(C(=O)O1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H16N2O3/c1-22-13-16-12-20(18(21)23-16)17-10-9-15(11-19-17)8-7-14-5-3-2-4-6-14/h2-6,9-11,16H,12-13H2,1H3
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n/an/an/an/a 47n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222731
PNG
(US9315498, 18)
Show SMILES CC(C)N1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C21H23N3O/c1-16(2)24-20(25)23(15-21(24,3)4)19-13-12-18(14-22-19)11-10-17-8-6-5-7-9-17/h5-9,12-14,16H,15H2,1-4H3
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n/an/an/an/a 39n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222741
PNG
(US9315498, 29)
Show SMILES CC1(C)CN(C(=O)O1)c1ccc(cn1)C#Cc1cncc(F)c1
Show InChI InChI=1S/C17H14FN3O2/c1-17(2)11-21(16(22)23-17)15-6-5-12(9-20-15)3-4-13-7-14(18)10-19-8-13/h5-10H,11H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222752
PNG
(US9315498, 40)
Show SMILES CC1(C)CN(C(=O)C1)c1ccc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C19H17FN2O/c1-19(2)11-18(23)22(13-19)17-9-8-15(12-21-17)7-6-14-4-3-5-16(20)10-14/h3-5,8-10,12H,11,13H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222757
PNG
(US9315498, 45)
Show SMILES CN1C(CN(C1=O)c1ccc(cn1)C#Cc1ccccc1)C1CCCC1
Show InChI InChI=1S/C22H23N3O/c1-24-20(19-9-5-6-10-19)16-25(22(24)26)21-14-13-18(15-23-21)12-11-17-7-3-2-4-8-17/h2-4,7-8,13-15,19-20H,5-6,9-10,16H2,1H3
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n/an/an/an/a 57n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222766
PNG
(US9315498, 54)
Show SMILES CN1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1cccc(Cl)c1
Show InChI InChI=1S/C19H18ClN3O/c1-19(2)13-23(18(24)22(19)3)17-10-9-15(12-21-17)8-7-14-5-4-6-16(20)11-14/h4-6,9-12H,13H2,1-3H3
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n/an/an/an/a 32n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222785
PNG
(US9315498, 71)
Show SMILES Fc1cccc(c1)C#Cc1ccc(nc1)N1CC2CCCCN2C1=O
Show InChI InChI=1S/C20H18FN3O/c21-17-5-3-4-15(12-17)7-8-16-9-10-19(22-13-16)24-14-18-6-1-2-11-23(18)20(24)25/h3-5,9-10,12-13,18H,1-2,6,11,14H2
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222803
PNG
(US9315498, 93)
Show SMILES CC1(C)CCCN(c2ccc(cn2)C#Cc2ccccc2)C(=O)O1
Show InChI InChI=1S/C20H20N2O2/c1-20(2)13-6-14-22(19(23)24-20)18-12-11-17(15-21-18)10-9-16-7-4-3-5-8-16/h3-5,7-8,11-12,15H,6,13-14H2,1-2H3
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n/an/an/an/a 36n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222804
PNG
(US9315498, 94)
Show SMILES O=C1OC2COCCC2N1c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H16N2O3/c22-19-21(16-10-11-23-13-17(16)24-19)18-9-8-15(12-20-18)7-6-14-4-2-1-3-5-14/h1-5,8-9,12,16-17H,10-11,13H2
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n/an/an/an/a 60n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222816
PNG
(US9315498, 107)
Show SMILES CN1C(CN(C1=O)c1ccc(cn1)C#Cc1ccccc1)C(C)(C)C
Show InChI InChI=1S/C21H23N3O/c1-21(2,3)18-15-24(20(25)23(18)4)19-13-12-17(14-22-19)11-10-16-8-6-5-7-9-16/h5-9,12-14,18H,15H2,1-4H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222826
PNG
(US9315498, 117)
Show SMILES O=C1CC2(CCCC2)CN1c1ncc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H19N3O/c24-18-12-20(10-4-5-11-20)15-23(18)19-21-13-17(14-22-19)9-8-16-6-2-1-3-7-16/h1-3,6-7,13-14H,4-5,10-12,15H2
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222832
PNG
(US9315498, 123)
Show SMILES CN1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C18H17FN4O/c1-18(2)12-23(17(24)22(18)3)16-20-10-14(11-21-16)8-7-13-5-4-6-15(19)9-13/h4-6,9-11H,12H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222837
PNG
(US9315498, 128 | US9315498, 130)
Show SMILES CO[C@H]1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H19N3O2/c1-19(2)13-22(17(23)16(19)24-3)18-20-11-15(12-21-18)10-9-14-7-5-4-6-8-14/h4-8,11-12,16H,13H2,1-3H3/t16-/m0/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222859
PNG
(US9315498, 145)
Show SMILES CC1CN(C(=O)OC1(C)C)c1ncc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H19N3O2/c1-14-13-22(18(23)24-19(14,2)3)17-20-11-16(12-21-17)10-9-15-7-5-4-6-8-15/h4-8,11-12,14H,13H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222863
PNG
(US9315498, 149)
Show SMILES CC1CN(C(=O)OC1(C)C)c1ncc(cn1)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C19H18FN3O2/c1-13-12-23(18(24)25-19(13,2)3)17-21-10-15(11-22-17)5-4-14-6-8-16(20)9-7-14/h6-11,13H,12H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222866
PNG
(US9315498, 152)
Show SMILES CC1(C)CN(C(=O)O1)c1ccc(nn1)C#Cc1ccccc1
Show InChI InChI=1S/C17H15N3O2/c1-17(2)12-20(16(21)22-17)15-11-10-14(18-19-15)9-8-13-6-4-3-5-7-13/h3-7,10-11H,12H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222872
PNG
(US9315498, 158)
Show SMILES CN1C(=O)N(CC1(C)C)c1cnc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C18H17FN4O/c1-18(2)12-23(17(24)22(18)3)16-11-20-15(10-21-16)8-7-13-5-4-6-14(19)9-13/h4-6,9-11H,12H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222876
PNG
(US9315498, 162)
Show SMILES CC1(C)CCN(C(=O)C1)c1cnc(cn1)C#Cc1cccnc1
Show InChI InChI=1S/C18H18N4O/c1-18(2)7-9-22(17(23)10-18)16-13-20-15(12-21-16)6-5-14-4-3-8-19-11-14/h3-4,8,11-13H,7,9-10H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222879
PNG
(US9315498, 165)
Show SMILES CN1C(=O)N(CCC1(C)C)c1cnc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H20N4O/c1-19(2)11-12-23(18(24)22(19)3)17-14-20-16(13-21-17)10-9-15-7-5-4-6-8-15/h4-8,13-14H,11-12H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222882
PNG
(US9315498, 168)
Show SMILES CC1(C)CCN(C(=O)O1)c1cnc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H17N3O2/c1-18(2)10-11-21(17(22)23-18)16-13-19-15(12-20-16)9-8-14-6-4-3-5-7-14/h3-7,12-13H,10-11H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222737
PNG
(US9315498, 25)
Show SMILES CC1(C)CNC(=O)N(C1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H19N3O/c1-19(2)13-21-18(23)22(14-19)17-11-10-16(12-20-17)9-8-15-6-4-3-5-7-15/h3-7,10-12H,13-14H2,1-2H3,(H,21,23)
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222749
PNG
(US9315498, 37)
Show SMILES CC1(C)CN(C(=O)C1)c1ccc(cn1)C#Cc1cncc(F)c1
Show InChI InChI=1S/C18H16FN3O/c1-18(2)8-17(23)22(12-18)16-6-5-13(10-21-16)3-4-14-7-15(19)11-20-9-14/h5-7,9-11H,8,12H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222779
PNG
(US9315498, 65)
Show SMILES COC1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C20H19FN2O2/c1-20(2)13-23(19(24)18(20)25-3)17-10-9-15(12-22-17)8-7-14-5-4-6-16(21)11-14/h4-6,9-12,18H,13H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222782
PNG
(US9315498, 68)
Show SMILES CN1C(=O)N(CCC1(C)C)c1ccc(cn1)C#Cc1cc(F)ccc1F
Show InChI InChI=1S/C20H19F2N3O/c1-20(2)10-11-25(19(26)24(20)3)18-9-5-14(13-23-18)4-6-15-12-16(21)7-8-17(15)22/h5,7-9,12-13H,10-11H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222787
PNG
(US9315498, 74)
Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1cncc(F)c1
Show InChI InChI=1S/C18H16FN3O2/c1-18(2)7-8-22(17(23)24-18)16-6-5-13(11-21-16)3-4-14-9-15(19)12-20-10-14/h5-6,9-12H,7-8H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM198912
PNG
(US9221802, Ref. Ex. 79 | US9315498, 79)
Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C19H17FN2O2/c1-19(2)11-12-22(18(23)24-19)17-10-7-15(13-21-17)4-3-14-5-8-16(20)9-6-14/h5-10,13H,11-12H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222794
PNG
(US9315498, 84)
Show SMILES CN1C2CCCCC2N(C1=O)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C21H21N3O/c1-23-18-9-5-6-10-19(18)24(21(23)25)20-14-13-17(15-22-20)12-11-16-7-3-2-4-8-16/h2-4,7-8,13-15,18-19H,5-6,9-10H2,1H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222823
PNG
(US9315498, 114)
Show SMILES COC1CN(C(=O)OC1(C)C)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H20N2O3/c1-20(2)17(24-3)14-22(19(23)25-20)18-12-11-16(13-21-18)10-9-15-7-5-4-6-8-15/h4-8,11-13,17H,14H2,1-3H3
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n/an/an/an/a 22n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222825
PNG
(US9315498, 116)
Show SMILES CC1(C)CCC(=O)N(C1)c1ncc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H19N3O/c1-19(2)11-10-17(23)22(14-19)18-20-12-16(13-21-18)9-8-15-6-4-3-5-7-15/h3-7,12-13H,10-11,14H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222829
PNG
(US9315498, 120)
Show SMILES CC1(C)CN(C(=O)C1)c1ncc(cn1)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C18H16FN3O/c1-18(2)9-16(23)22(12-18)17-20-10-14(11-21-17)4-3-13-5-7-15(19)8-6-13/h5-8,10-11H,9,12H2,1-2H3
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n/an/an/an/a 92n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222831
PNG
(US9315498, 122)
Show SMILES CN1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H18N4O/c1-18(2)13-22(17(23)21(18)3)16-19-11-15(12-20-16)10-9-14-7-5-4-6-8-14/h4-8,11-12H,13H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222853
PNG
(US9315498, 139)
Show SMILES CN1C(=O)N(CCC1(C)C)c1ncc(cn1)C#Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H18F2N4O/c1-19(2)8-9-25(18(26)24(19)3)17-22-11-13(12-23-17)4-5-14-10-15(20)6-7-16(14)21/h6-7,10-12H,8-9H2,1-3H3
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n/an/an/an/a 57n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222873
PNG
(US9315498, 159)
Show SMILES CN1C(=O)N(CC1(C)C)c1cnc(cn1)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C18H17FN4O/c1-18(2)12-23(17(24)22(18)3)16-11-20-15(10-21-16)9-6-13-4-7-14(19)8-5-13/h4-5,7-8,10-11H,12H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222875
PNG
(US9315498, 161)
Show SMILES CC1(C)CCN(C(=O)C1)c1cnc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C19H18FN3O/c1-19(2)8-9-23(18(24)11-19)17-13-21-16(12-22-17)7-6-14-4-3-5-15(20)10-14/h3-5,10,12-13H,8-9,11H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222885
PNG
(US9315498, 171)
Show SMILES CC1CN(C(=O)CO1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H16N2O2/c1-14-12-20(18(21)13-22-14)17-10-9-16(11-19-17)8-7-15-5-3-2-4-6-15/h2-6,9-11,14H,12-13H2,1H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222726
PNG
(US9315498, 13)
Show SMILES CC1(C)CN(C(=O)C1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H18N2O/c1-19(2)12-18(22)21(14-19)17-11-10-16(13-20-17)9-8-15-6-4-3-5-7-15/h3-7,10-11,13H,12,14H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222730
PNG
(US9315498, 17)
Show SMILES CCN1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H21N3O/c1-4-23-19(24)22(15-20(23,2)3)18-13-12-17(14-21-18)11-10-16-8-6-5-7-9-16/h5-9,12-14H,4,15H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222742
PNG
(US9315498, 30)
Show SMILES CC1(C)CN(C(=O)O1)c1ccc(cn1)C#Cc1cncnc1
Show InChI InChI=1S/C16H14N4O2/c1-16(2)10-20(15(21)22-16)14-6-5-12(9-19-14)3-4-13-7-17-11-18-8-13/h5-9,11H,10H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222743
PNG
(US9315498, 31)
Show SMILES Cn1cc(cn1)C#Cc1ccc(nc1)N1CC(C)(C)OC1=O
Show InChI InChI=1S/C16H16N4O2/c1-16(2)11-20(15(21)22-16)14-7-6-12(8-17-14)4-5-13-9-18-19(3)10-13/h6-10H,11H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222748
PNG
(US9315498, 36)
Show SMILES O=C1OC2(CC2)CN1c1ccc(cn1)C#Cc1cccnc1
Show InChI InChI=1S/C17H13N3O2/c21-16-20(12-17(22-16)7-8-17)15-6-5-14(11-19-15)4-3-13-2-1-9-18-10-13/h1-2,5-6,9-11H,7-8,12H2
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222755
PNG
(US9315498, 43)
Show SMILES CC1(C)CCC(=O)N(C1)c1ccc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C20H19FN2O/c1-20(2)11-10-19(24)23(14-20)18-9-8-16(13-22-18)7-6-15-4-3-5-17(21)12-15/h3-5,8-9,12-13H,10-11,14H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222778
PNG
(US9315498, 64)
Show SMILES COC1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1cccc(C)c1
Show InChI InChI=1S/C21H22N2O2/c1-15-6-5-7-16(12-15)8-9-17-10-11-18(22-13-17)23-14-21(2,3)19(25-4)20(23)24/h5-7,10-13,19H,14H2,1-4H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM198911
PNG
(US9221802, Ref. Ex. 76 | US9315498, 76)
Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C19H17FN2O2/c1-19(2)10-11-22(18(23)24-19)17-9-8-15(13-21-17)7-6-14-4-3-5-16(20)12-14/h3-5,8-9,12-13H,10-11H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222789
PNG
(US9315498, 77)
Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1cccc(Cl)c1
Show InChI InChI=1S/C19H17ClN2O2/c1-19(2)10-11-22(18(23)24-19)17-9-8-15(13-21-17)7-6-14-4-3-5-16(20)12-14/h3-5,8-9,12-13H,10-11H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222793
PNG
(US9315498, 83)
Show SMILES CN1C(CN(C1=O)c1ccc(cn1)C#Cc1ccccc1)C1CC1
Show InChI InChI=1S/C20H19N3O/c1-22-18(17-10-11-17)14-23(20(22)24)19-12-9-16(13-21-19)8-7-15-5-3-2-4-6-15/h2-6,9,12-13,17-18H,10-11,14H2,1H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222808
PNG
(US9315498, 98)
Show SMILES O=C1[C@H]2CCC[C@H]2N1c1ccc(cn1)C#Cc1cccnc1
Show InChI InChI=1S/C18H15N3O/c22-18-15-4-1-5-16(15)21(18)17-9-8-14(12-20-17)7-6-13-3-2-10-19-11-13/h2-3,8-12,15-16H,1,4-5H2/t15-,16+/m0/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222810
PNG
(US9315498, 100)
Show SMILES CCN1C2CCCCC2N(C1=O)c1ccc(cn1)C#Cc1cccnc1
Show InChI InChI=1S/C21H22N4O/c1-2-24-18-7-3-4-8-19(18)25(21(24)26)20-12-11-17(15-23-20)10-9-16-6-5-13-22-14-16/h5-6,11-15,18-19H,2-4,7-8H2,1H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222811
PNG
(US9315498, 101)
Show SMILES CC(C)N1C2CCCCC2N(C1=O)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C23H25N3O/c1-17(2)25-20-10-6-7-11-21(20)26(23(25)27)22-15-14-19(16-24-22)13-12-18-8-4-3-5-9-18/h3-5,8-9,14-17,20-21H,6-7,10-11H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222834
PNG
(US9315498, 125)
Show SMILES CN1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C18H17FN4O/c1-18(2)12-23(17(24)22(18)3)16-20-10-14(11-21-16)5-4-13-6-8-15(19)9-7-13/h6-11H,12H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222843
PNG
(US9315498, 132)
Show SMILES CO[C@@H]1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C19H18FN3O2/c1-19(2)12-23(17(24)16(19)25-3)18-21-10-14(11-22-18)8-7-13-5-4-6-15(20)9-13/h4-6,9-11,16H,12H2,1-3H3/t16-/m1/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222850
PNG
(US9315498, 136)
Show SMILES CC1(C)CCN(C(=O)C1)c1ncc(cn1)C#Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H17F2N3O/c1-19(2)7-8-24(17(25)10-19)18-22-11-13(12-23-18)3-4-14-9-15(20)5-6-16(14)21/h5-6,9,11-12H,7-8,10H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222851
PNG
(US9315498, 137)
Show SMILES CN1C(=O)N(CCC1(C)C)c1ncc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H20N4O/c1-19(2)11-12-23(18(24)22(19)3)17-20-13-16(14-21-17)10-9-15-7-5-4-6-8-15/h4-8,13-14H,11-12H2,1-3H3
PDB

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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222852
PNG
(US9315498, 138)
Show SMILES CN1C(=O)N(CCC1(C)C)c1ncc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C19H19FN4O/c1-19(2)9-10-24(18(25)23(19)3)17-21-12-15(13-22-17)8-7-14-5-4-6-16(20)11-14/h4-6,11-13H,9-10H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222860
PNG
(US9315498, 146)
Show SMILES CC1CN(C(=O)OC1(C)C)c1ncc(cn1)C#Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H17F2N3O2/c1-12-11-24(18(25)26-19(12,2)3)17-22-9-13(10-23-17)4-5-14-8-15(20)6-7-16(14)21/h6-10,12H,11H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222862
PNG
(US9315498, 148)
Show SMILES CC1CN(C(=O)OC1(C)C)c1ncc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C19H18FN3O2/c1-13-12-23(18(24)25-19(13,2)3)17-21-10-15(11-22-17)8-7-14-5-4-6-16(20)9-14/h4-6,9-11,13H,12H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222881
PNG
(US9315498, 167)
Show SMILES CN1C(=O)N(CCC1(C)C)c1cnc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C19H19FN4O/c1-19(2)9-10-24(18(25)23(19)3)17-13-21-16(12-22-17)8-7-14-5-4-6-15(20)11-14/h4-6,11-13H,9-10H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222888
PNG
(US9315498, 174)
Show SMILES CN1[C@H]2CCC[C@H]2N(C1=O)c1ccc(nn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C19H17FN4O/c1-23-16-6-3-7-17(16)24(19(23)25)18-11-10-15(21-22-18)9-8-13-4-2-5-14(20)12-13/h2,4-5,10-12,16-17H,3,6-7H2,1H3/t16-,17+/m0/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222716
PNG
(US9315498, 4)
Show SMILES COC[C@@H]1CN(C(=O)O1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H16N2O3/c1-22-13-16-12-20(18(21)23-16)17-10-9-15(11-19-17)8-7-14-5-3-2-4-6-14/h2-6,9-11,16H,12-13H2,1H3/t16-/m0/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM198909
PNG
(US9221802, Ref. Ex. 20 | US9315498, 20)
Show SMILES CC1(C)COC(=O)N(C1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H18N2O2/c1-19(2)13-21(18(22)23-14-19)17-11-10-16(12-20-17)9-8-15-6-4-3-5-7-15/h3-7,10-12H,13-14H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222733
PNG
(US9315498, 21)
Show SMILES CC1(C)CN(C(=O)C1)c1ncc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C19H17FN2O/c1-19(2)11-17(23)22(13-19)18-16(20)10-15(12-21-18)9-8-14-6-4-3-5-7-14/h3-7,10,12H,11,13H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222746
PNG
(US9315498, 34)
Show SMILES CC1(C)CN(C(=O)O1)c1ccc(cn1)C#Cc1cc(F)ccc1F
Show InChI InChI=1S/C18H14F2N2O2/c1-18(2)11-22(17(23)24-18)16-8-4-12(10-21-16)3-5-13-9-14(19)6-7-15(13)20/h4,6-10H,11H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222750
PNG
(US9315498, 38)
Show SMILES CC1(C)CN(C(=O)C1)c1ccc(cn1)C#Cc1cccnc1
Show InChI InChI=1S/C18H17N3O/c1-18(2)10-17(22)21(13-18)16-8-7-15(12-20-16)6-5-14-4-3-9-19-11-14/h3-4,7-9,11-12H,10,13H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222763
PNG
(US9315498, 51)
Show SMILES CN1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1cncc(Cl)c1
Show InChI InChI=1S/C18H17ClN4O/c1-18(2)12-23(17(24)22(18)3)16-7-6-13(10-21-16)4-5-14-8-15(19)11-20-9-14/h6-11H,12H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222784
PNG
(US9315498, 70)
Show SMILES O=C1N2CCCCC2CN1c1ccc(cn1)C#Cc1cccnc1
Show InChI InChI=1S/C19H18N4O/c24-19-22-11-2-1-5-17(22)14-23(19)18-9-8-16(13-21-18)7-6-15-4-3-10-20-12-15/h3-4,8-10,12-13,17H,1-2,5,11,14H2
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222791
PNG
(US9315498, 80)
Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1ccc(F)c(F)c1
Show InChI InChI=1S/C19H16F2N2O2/c1-19(2)9-10-23(18(24)25-19)17-8-6-14(12-22-17)4-3-13-5-7-15(20)16(21)11-13/h5-8,11-12H,9-10H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222799
PNG
(US9315498, 89)
Show SMILES CC1(C)CCN(C(=O)C1)c1ccc(cn1)C#Cc1cccc(Cl)c1
Show InChI InChI=1S/C20H19ClN2O/c1-20(2)10-11-23(19(24)13-20)18-9-8-16(14-22-18)7-6-15-4-3-5-17(21)12-15/h3-5,8-9,12,14H,10-11,13H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222801
PNG
(US9315498, 91)
Show SMILES CC1(C)CCN(C(=O)C1)c1ccc(cn1)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C20H19FN2O/c1-20(2)11-12-23(19(24)13-20)18-10-7-16(14-22-18)4-3-15-5-8-17(21)9-6-15/h5-10,14H,11-13H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM198914
PNG
(US9221802, Ref. Ex. 103 | US9315498, 103)
Show SMILES O=C1O[C@H]2CCC[C@H]2CN1c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H18N2O2/c23-20-22(14-17-7-4-8-18(17)24-20)19-12-11-16(13-21-19)10-9-15-5-2-1-3-6-15/h1-3,5-6,11-13,17-18H,4,7-8,14H2/t17-,18-/m0/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222814
PNG
(US9315498, 105)
Show SMILES COCC1CCN(C(=O)O1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H18N2O3/c1-23-14-17-11-12-21(19(22)24-17)18-10-9-16(13-20-18)8-7-15-5-3-2-4-6-15/h2-6,9-10,13,17H,11-12,14H2,1H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222821
PNG
(US9315498, 112)
Show SMILES CN1C(=O)N(CC11CC1)c1ccc(cn1)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C19H16FN3O/c1-22-18(24)23(13-19(22)10-11-19)17-9-6-15(12-21-17)3-2-14-4-7-16(20)8-5-14/h4-9,12H,10-11,13H2,1H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222830
PNG
(US9315498, 121)
Show SMILES CC1(C)CN(C(=O)C1)c1ncc(cn1)C#Cc1cc(F)ccc1F
Show InChI InChI=1S/C18H15F2N3O/c1-18(2)8-16(24)23(11-18)17-21-9-12(10-22-17)3-4-13-7-14(19)5-6-15(13)20/h5-7,9-10H,8,11H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222837
PNG
(US9315498, 128 | US9315498, 130)
Show SMILES CO[C@H]1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H19N3O2/c1-19(2)13-22(17(23)16(19)24-3)18-20-11-15(12-21-18)10-9-14-7-5-4-6-8-14/h4-8,11-12,16H,13H2,1-3H3/t16-/m0/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222846
PNG
(US9315498, 133)
Show SMILES CO[C@H]1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H17F2N3O2/c1-19(2)11-24(17(25)16(19)26-3)18-22-9-12(10-23-18)4-5-13-8-14(20)6-7-15(13)21/h6-10,16H,11H2,1-3H3/t16-/m0/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222868
PNG
(US9315498, 154)
Show SMILES CN1C(=O)N(CC1(C)C)c1ccc(nn1)C#Cc1cccc(C)c1
Show InChI InChI=1S/C19H20N4O/c1-14-6-5-7-15(12-14)8-9-16-10-11-17(21-20-16)23-13-19(2,3)22(4)18(23)24/h5-7,10-12H,13H2,1-4H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222720
PNG
(US9315498, 7)
Show SMILES CC1(C)CN(C(=O)O1)c1ccc(cn1)C#Cc1cccnc1
Show InChI InChI=1S/C17H15N3O2/c1-17(2)12-20(16(21)22-17)15-8-7-14(11-19-15)6-5-13-4-3-9-18-10-13/h3-4,7-11H,12H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222734
PNG
(US9315498, 22)
Show SMILES O=C1O[C@H]2CCC[C@H]2N1c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H16N2O2/c22-19-21(16-7-4-8-17(16)23-19)18-12-11-15(13-20-18)10-9-14-5-2-1-3-6-14/h1-3,5-6,11-13,16-17H,4,7-8H2/t16-,17+/m1/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222736
PNG
(US9315498, 24)
Show SMILES Fc1cncc(c1)C#Cc1ccc(nc1)N1[C@@H]2CCC[C@@H]2OC1=O
Show InChI InChI=1S/C18H14FN3O2/c19-14-8-13(9-20-11-14)5-4-12-6-7-17(21-10-12)22-15-2-1-3-16(15)24-18(22)23/h6-11,15-16H,1-3H2/t15-,16+/m1/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222753
PNG
(US9315498, 41)
Show SMILES Cc1cc(cnc1N1CC(C)(C)CC1=O)C#Cc1ccccc1
Show InChI InChI=1S/C20H20N2O/c1-15-11-17(10-9-16-7-5-4-6-8-16)13-21-19(15)22-14-20(2,3)12-18(22)23/h4-8,11,13H,12,14H2,1-3H3
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n/an/an/an/a 58n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222756
PNG
(US9315498, 44)
Show SMILES CN1C(=O)N(CC11CCCC1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C21H21N3O/c1-23-20(25)24(16-21(23)13-5-6-14-21)19-12-11-18(15-22-19)10-9-17-7-3-2-4-8-17/h2-4,7-8,11-12,15H,5-6,13-14,16H2,1H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222762
PNG
(US9315498, 50)
Show SMILES CN1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1cnn(C)c1
Show InChI InChI=1S/C17H19N5O/c1-17(2)12-22(16(23)21(17)4)15-8-7-13(9-18-15)5-6-14-10-19-20(3)11-14/h7-11H,12H2,1-4H3
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n/an/an/an/a 27n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222764
PNG
(US9315498, 52)
Show SMILES CN1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1ccnnc1
Show InChI InChI=1S/C17H17N5O/c1-17(2)12-22(16(23)21(17)3)15-7-6-13(10-18-15)4-5-14-8-9-19-20-11-14/h6-11H,12H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222768
PNG
(US9315498, 56)
Show SMILES CN1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1cccc(C)c1
Show InChI InChI=1S/C20H21N3O/c1-15-6-5-7-16(12-15)8-9-17-10-11-18(21-13-17)23-14-20(2,3)22(4)19(23)24/h5-7,10-13H,14H2,1-4H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222775
PNG
(US9315498, 62)
Show SMILES CO[C@@H]1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H20N2O2/c1-20(2)14-22(19(23)18(20)24-3)17-12-11-16(13-21-17)10-9-15-7-5-4-6-8-15/h4-8,11-13,18H,14H2,1-3H3/t18-/m1/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222786
PNG
(US9315498, 73)
Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1cccnc1
Show InChI InChI=1S/C18H17N3O2/c1-18(2)9-11-21(17(22)23-18)16-8-7-15(13-20-16)6-5-14-4-3-10-19-12-14/h3-4,7-8,10,12-13H,9,11H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222796
PNG
(US9315498, 86)
Show SMILES CN1C2CCCCC2N(C1=O)c1ccc(cn1)C#Cc1cncc(F)c1
Show InChI InChI=1S/C20H19FN4O/c1-24-17-4-2-3-5-18(17)25(20(24)26)19-9-8-14(12-23-19)6-7-15-10-16(21)13-22-11-15/h8-13,17-18H,2-5H2,1H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222802
PNG
(US9315498, 92)
Show SMILES CC1(C)CCN(C(=O)C1)c1ccc(cn1)C#Cc1cc(F)ccc1F
Show InChI InChI=1S/C20H18F2N2O/c1-20(2)9-10-24(19(25)12-20)18-8-4-14(13-23-18)3-5-15-11-16(21)6-7-17(15)22/h4,6-8,11,13H,9-10,12H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222819
PNG
(US9315498, 110)
Show SMILES CN1C(=O)N(CC1(C)C)c1ncc(cc1F)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C19H17F2N3O/c1-19(2)12-24(18(25)23(19)3)17-16(21)10-14(11-22-17)5-4-13-6-8-15(20)9-7-13/h6-11H,12H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222820
PNG
(US9315498, 111)
Show SMILES CN1C(=O)N(CC1(C)C)c1ncc(cc1F)C#Cc1cccc(F)c1
Show InChI InChI=1S/C19H17F2N3O/c1-19(2)12-24(18(25)23(19)3)17-16(21)10-14(11-22-17)8-7-13-5-4-6-15(20)9-13/h4-6,9-11H,12H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222824
PNG
(US9315498, 115)
Show SMILES CC1(C)CN(C(=O)C1)c1ncc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H17N3O/c1-18(2)10-16(22)21(13-18)17-19-11-15(12-20-17)9-8-14-6-4-3-5-7-14/h3-7,11-12H,10,13H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222827
PNG
(US9315498, 118)
Show SMILES CC1(C)CN(C(=O)C1)c1ncc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C18H16FN3O/c1-18(2)9-16(23)22(12-18)17-20-10-14(11-21-17)7-6-13-4-3-5-15(19)8-13/h3-5,8,10-11H,9,12H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222828
PNG
(US9315498, 119)
Show SMILES CC1(C)CN(C(=O)C1)c1ncc(cn1)C#Cc1cccc(Cl)c1
Show InChI InChI=1S/C18H16ClN3O/c1-18(2)9-16(23)22(12-18)17-20-10-14(11-21-17)7-6-13-4-3-5-15(19)8-13/h3-5,8,10-11H,9,12H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222849
PNG
(US9315498, 135)
Show SMILES CC1(C)CCN(C(=O)C1)c1ncc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C19H18FN3O/c1-19(2)8-9-23(17(24)11-19)18-21-12-15(13-22-18)7-6-14-4-3-5-16(20)10-14/h3-5,10,12-13H,8-9,11H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222856
PNG
(US9315498, 142)
Show SMILES CC(C)N1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C20H21FN4O/c1-14(2)25-19(26)24(13-20(25,3)4)18-22-11-16(12-23-18)6-5-15-7-9-17(21)10-8-15/h7-12,14H,13H2,1-4H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222857
PNG
(US9315498, 143)
Show SMILES CCN1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C19H19FN4O/c1-4-24-18(25)23(13-19(24,2)3)17-21-11-15(12-22-17)6-5-14-7-9-16(20)10-8-14/h7-12H,4,13H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222870
PNG
(US9315498, 156)
Show SMILES CN1C(=O)N(CC1(C)C)c1cnc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H18N4O/c1-18(2)13-22(17(23)21(18)3)16-12-19-15(11-20-16)10-9-14-7-5-4-6-8-14/h4-8,11-12H,13H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222871
PNG
(US9315498, 157)
Show SMILES CN1C(=O)N(CC1(C)C)c1cnc(cn1)C#Cc1cccnc1
Show InChI InChI=1S/C17H17N5O/c1-17(2)12-22(16(23)21(17)3)15-11-19-14(10-20-15)7-6-13-5-4-8-18-9-13/h4-5,8-11H,12H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222712
PNG
(US9315498, 1)
Show SMILES CC1(C)CN(C(=O)O1)c1ncc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C18H15FN2O2/c1-18(2)12-21(17(22)23-18)16-15(19)10-14(11-20-16)9-8-13-6-4-3-5-7-13/h3-7,10-11H,12H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222714
PNG
(US9315498, 3)
Show SMILES COC[C@H]1CN(C(=O)O1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H16N2O3/c1-22-13-16-12-20(18(21)23-16)17-10-9-15(11-19-17)8-7-14-5-3-2-4-6-14/h2-6,9-11,16H,12-13H2,1H3/t16-/m1/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222722
PNG
(US9315498, 9)
Show SMILES O=C1OC2(CC2)CN1c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H14N2O2/c21-17-20(13-18(22-17)10-11-18)16-9-8-15(12-19-16)7-6-14-4-2-1-3-5-14/h1-5,8-9,12H,10-11,13H2
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222725
PNG
(US9315498, 12)
Show SMILES O=C1OC2(CN1c1ccc(cn1)C#Cc1ccccc1)CCCCC2
Show InChI InChI=1S/C21H20N2O2/c24-20-23(16-21(25-20)13-5-2-6-14-21)19-12-11-18(15-22-19)10-9-17-7-3-1-4-8-17/h1,3-4,7-8,11-12,15H,2,5-6,13-14,16H2
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222738
PNG
(US9315498, 26)
Show SMILES CN1CC(C)(C)CN(C1=O)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H21N3O/c1-20(2)14-22(3)19(24)23(15-20)18-12-11-17(13-21-18)10-9-16-7-5-4-6-8-16/h4-8,11-13H,14-15H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222739
PNG
(US9315498, 27)
Show SMILES CC1N(C(=O)OC1(C)C)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C19H18N2O2/c1-14-19(2,3)23-18(22)21(14)17-12-11-16(13-20-17)10-9-15-7-5-4-6-8-15/h4-8,11-14H,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222759
PNG
(US9315498, 47)
Show SMILES O=C1O[C@H]2CCCC[C@H]2N1c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H18N2O2/c23-20-22(17-8-4-5-9-18(17)24-20)19-13-12-16(14-21-19)11-10-15-6-2-1-3-7-15/h1-3,6-7,12-14,17-18H,4-5,8-9H2/t17-,18+/m1/s1
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222760
PNG
(US9315498, 48)
Show SMILES CN1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1cccnc1
Show InChI InChI=1S/C18H18N4O/c1-18(2)13-22(17(23)21(18)3)16-9-8-15(12-20-16)7-6-14-5-4-10-19-11-14/h4-5,8-12H,13H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222769
PNG
(US9315498, 57)
Show SMILES CN1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C19H18FN3O/c1-19(2)13-23(18(24)22(19)3)17-11-8-15(12-21-17)5-4-14-6-9-16(20)10-7-14/h6-12H,13H2,1-3H3
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n/an/an/an/a 35n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222770
PNG
(US9315498, 58)
Show SMILES O=C1N2CCCCC2CN1c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H19N3O/c24-20-22-13-5-4-8-18(22)15-23(20)19-12-11-17(14-21-19)10-9-16-6-2-1-3-7-16/h1-3,6-7,11-12,14,18H,4-5,8,13,15H2
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n/an/an/an/a 33n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222771
PNG
(US9315498, 59)
Show SMILES O=C1CC2(CCCC2)CN1c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C21H20N2O/c24-20-14-21(12-4-5-13-21)16-23(20)19-11-10-18(15-22-19)9-8-17-6-2-1-3-7-17/h1-3,6-7,10-11,15H,4-5,12-14,16H2
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n/an/an/an/a 16n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222773
PNG
(US9315498, 61)
Show SMILES CO[C@H]1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H20N2O2/c1-20(2)14-22(19(23)18(20)24-3)17-12-11-16(13-21-17)10-9-15-7-5-4-6-8-15/h4-8,11-13,18H,14H2,1-3H3/t18-/m0/s1
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n/an/an/an/a 75n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222777
PNG
(US9315498, 63)
Show SMILES COC1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1cncc(Cl)c1
Show InChI InChI=1S/C19H18ClN3O2/c1-19(2)12-23(18(24)17(19)25-3)16-7-6-13(10-22-16)4-5-14-8-15(20)11-21-9-14/h6-11,17H,12H2,1-3H3
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n/an/an/an/a 70n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222780
PNG
(US9315498, 66)
Show SMILES COC1C(=O)N(CC1(C)C)c1ccc(cn1)C#Cc1ccc(F)cc1
Show InChI InChI=1S/C20H19FN2O2/c1-20(2)13-23(19(24)18(20)25-3)17-11-8-15(12-22-17)5-4-14-6-9-16(21)10-7-14/h6-12,18H,13H2,1-3H3
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n/an/an/an/a 75n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222788
PNG
(US9315498, 75)
Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1cncc(Cl)c1
Show InChI InChI=1S/C18H16ClN3O2/c1-18(2)7-8-22(17(23)24-18)16-6-5-13(11-21-16)3-4-14-9-15(19)12-20-10-14/h5-6,9-12H,7-8H2,1-2H3
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n/an/an/an/a 27n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM198913
PNG
(US9221802, Ref. Ex. 81 | US9315498, 81)
Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H16F2N2O2/c1-19(2)9-10-23(18(24)25-19)17-8-4-13(12-22-17)3-5-14-11-15(20)6-7-16(14)21/h4,6-8,11-12H,9-10H2,1-2H3
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n/an/an/an/a 12n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222795
PNG
(US9315498, 85)
Show SMILES CN1C2CCCCC2N(C1=O)c1ccc(cn1)C#Cc1cccnc1
Show InChI InChI=1S/C20H20N4O/c1-23-17-6-2-3-7-18(17)24(20(23)25)19-11-10-16(14-22-19)9-8-15-5-4-12-21-13-15/h4-5,10-14,17-18H,2-3,6-7H2,1H3
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n/an/an/an/a 27n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222797
PNG
(US9315498, 87)
Show SMILES CC1(C)CCN(C(=O)C1)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H20N2O/c1-20(2)12-13-22(19(23)14-20)18-11-10-17(15-21-18)9-8-16-6-4-3-5-7-16/h3-7,10-11,15H,12-14H2,1-2H3
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n/an/an/an/a 12n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222798
PNG
(US9315498, 88)
Show SMILES CC1(C)CCN(C(=O)C1)c1ccc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C20H19FN2O/c1-20(2)10-11-23(19(24)13-20)18-9-8-16(14-22-18)7-6-15-4-3-5-17(21)12-15/h3-5,8-9,12,14H,10-11,13H2,1-2H3
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n/an/an/an/a 19n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222807
PNG
(US9315498, 97)
Show SMILES CC1(C)CN(C1=O)c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H16N2O/c1-18(2)13-20(17(18)21)16-11-10-15(12-19-16)9-8-14-6-4-3-5-7-14/h3-7,10-12H,13H2,1-2H3
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n/an/an/an/a 36n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222822
PNG
(US9315498, 113)
Show SMILES CN1C(=O)N(CC11CC1)c1ccc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C19H16FN3O/c1-22-18(24)23(13-19(22)9-10-19)17-8-7-15(12-21-17)6-5-14-3-2-4-16(20)11-14/h2-4,7-8,11-12H,9-10,13H2,1H3
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n/an/an/an/a 51n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222854
PNG
(US9315498, 140)
Show SMILES CC(C)N1C(=O)N(CC1(C)C)c1ncc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C20H22N4O/c1-15(2)24-19(25)23(14-20(24,3)4)18-21-12-17(13-22-18)11-10-16-8-6-5-7-9-16/h5-9,12-13,15H,14H2,1-4H3
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n/an/an/an/a 28n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222861
PNG
(US9315498, 147)
Show SMILES CN1C(=O)N(CC11CC1)c1ncc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H16N4O/c1-21-17(23)22(13-18(21)9-10-18)16-19-11-15(12-20-16)8-7-14-5-3-2-4-6-14/h2-6,11-12H,9-10,13H2,1H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222864
PNG
(US9315498, 150)
Show SMILES CC1(C)CN(C(=O)C1)c1ccc(nn1)C#Cc1ccccc1
Show InChI InChI=1S/C18H17N3O/c1-18(2)12-17(22)21(13-18)16-11-10-15(19-20-16)9-8-14-6-4-3-5-7-14/h3-7,10-11H,12-13H2,1-2H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222880
PNG
(US9315498, 166)
Show SMILES CC1(C)CCN(C(=O)N1)c1cnc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C18H17FN4O/c1-18(2)8-9-23(17(24)22-18)16-12-20-15(11-21-16)7-6-13-4-3-5-14(19)10-13/h3-5,10-12H,8-9H2,1-2H3,(H,22,24)
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222883
PNG
(US9315498, 169)
Show SMILES COC1CN(C(=O)OC1(C)C)c1ccc(cn1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C20H19FN2O3/c1-20(2)17(25-3)13-23(19(24)26-20)18-10-9-15(12-22-18)8-7-14-5-4-6-16(21)11-14/h4-6,9-12,17H,13H2,1-3H3
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HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5a (mGluR5)


(Homo sapiens (Human))
BDBM222887
PNG
(US9315498, 173)
Show SMILES O=C1CS(=O)(=O)CCN1c1ccc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C17H14N2O3S/c20-17-13-23(21,22)11-10-19(17)16-9-8-15(12-18-16)7-6-14-4-2-1-3-5-14/h1-5,8-9,12H,10-11,13H2
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n/an/an/an/a 29n/an/an/an/a



HOFFMAN-LA ROCHE INC.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%