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Patent code US9315514

Compile Data Set for Download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50354578
PNG
(BUPRENORPHINE | US9315514, Buprenorphine)
Show SMILES CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45
Show InChI InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29+/m1/s1
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US Patent
0.0400n/an/an/an/an/an/an/an/a



Rhodes Technologies

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222959
PNG
(US9315514, 3)
Show SMILES CC(C)(C)[C@@]1(C)OCO[C@]23CC[C@@]4(C[C@H]12)[C@H]1Cc2ccc(O)c5O[C@@H]3[C@]4(CCN1CC1CC1)c25
Show InChI InChI=1S/C29H39NO4/c1-25(2,3)26(4)20-14-27-9-10-29(20,33-16-32-26)24-28(27)11-12-30(15-17-5-6-17)21(27)13-18-7-8-19(31)23(34-24)22(18)28/h7-8,17,20-21,24,31H,5-6,9-16H2,1-4H3/t20-,21-,24-,26+,27-,28+,29-/m1/s1
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0.120n/an/an/an/an/an/an/an/a



Rhodes Technologies

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Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222960
PNG
(US9315514, 4)
Show SMILES CCC1O[C@@](C)([C@H]2C[C@]34CC[C@]2(O1)[C@@H]1Oc2c5c(C[C@H]3N(CC3CC3)CC[C@@]415)ccc2O)C(C)(C)C
Show InChI InChI=1S/C31H43NO4/c1-6-23-35-28(5,27(2,3)4)21-16-29-11-12-31(21,36-23)26-30(29)13-14-32(17-18-7-8-18)22(29)15-19-9-10-20(33)25(34-26)24(19)30/h9-10,18,21-23,26,33H,6-8,11-17H2,1-5H3/t21-,22-,23?,26-,28+,29-,30+,31-/m1/s1
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Rhodes Technologies

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Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50354578
PNG
(BUPRENORPHINE | US9315514, Buprenorphine)
Show SMILES CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45
Show InChI InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29+/m1/s1
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Rhodes Technologies

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Assay Description
Radioligand dose-displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membr...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM222960
PNG
(US9315514, 4)
Show SMILES CCC1O[C@@](C)([C@H]2C[C@]34CC[C@]2(O1)[C@@H]1Oc2c5c(C[C@H]3N(CC3CC3)CC[C@@]415)ccc2O)C(C)(C)C
Show InChI InChI=1S/C31H43NO4/c1-6-23-35-28(5,27(2,3)4)21-16-29-11-12-31(21,36-23)26-30(29)13-14-32(17-18-7-8-18)22(29)15-19-9-10-20(33)25(34-26)24(19)30/h9-10,18,21-23,26,33H,6-8,11-17H2,1-5H3/t21-,22-,23?,26-,28+,29-,30+,31-/m1/s1
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Rhodes Technologies

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Assay Description
Radioligand dose-displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membr...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222963
PNG
(US9315514, 11)
Show InChI InChI=1S/C29H37NO4/c1-25(2,3)26(4)20-14-27-9-10-29(20,33-16-32-26)24-28(27)11-12-30(15-17-5-6-17)21(27)13-18-7-8-19(31)23(34-24)22(18)28/h7-10,17,20-21,24,31H,5-6,11-16H2,1-4H3/t20-,21-,24-,26+,27-,28+,29-/m1/s1
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Rhodes Technologies

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Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM222959
PNG
(US9315514, 3)
Show SMILES CC(C)(C)[C@@]1(C)OCO[C@]23CC[C@@]4(C[C@H]12)[C@H]1Cc2ccc(O)c5O[C@@H]3[C@]4(CCN1CC1CC1)c25
Show InChI InChI=1S/C29H39NO4/c1-25(2,3)26(4)20-14-27-9-10-29(20,33-16-32-26)24-28(27)11-12-30(15-17-5-6-17)21(27)13-18-7-8-19(31)23(34-24)22(18)28/h7-8,17,20-21,24,31H,5-6,9-16H2,1-4H3/t20-,21-,24-,26+,27-,28+,29-/m1/s1
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Rhodes Technologies

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Assay Description
Radioligand dose-displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membr...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM222961
PNG
(US9315514, 5)
Show SMILES CCCC1O[C@@](C)([C@H]2C[C@]34CC[C@]2(O1)[C@@H]1Oc2c5c(C[C@H]3N(CC3CC3)CC[C@@]415)ccc2O)C(C)(C)C
Show InChI InChI=1S/C32H45NO4/c1-6-7-24-36-29(5,28(2,3)4)22-17-30-12-13-32(22,37-24)27-31(30)14-15-33(18-19-8-9-19)23(30)16-20-10-11-21(34)26(35-27)25(20)31/h10-11,19,22-24,27,34H,6-9,12-18H2,1-5H3/t22-,23-,24?,27-,29+,30-,31+,32-/m1/s1
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Rhodes Technologies

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Assay Description
Radioligand dose-displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membr...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222961
PNG
(US9315514, 5)
Show SMILES CCCC1O[C@@](C)([C@H]2C[C@]34CC[C@]2(O1)[C@@H]1Oc2c5c(C[C@H]3N(CC3CC3)CC[C@@]415)ccc2O)C(C)(C)C
Show InChI InChI=1S/C32H45NO4/c1-6-7-24-36-29(5,28(2,3)4)22-17-30-12-13-32(22,37-24)27-31(30)14-15-33(18-19-8-9-19)23(30)16-20-10-11-21(34)26(35-27)25(20)31/h10-11,19,22-24,27,34H,6-9,12-18H2,1-5H3/t22-,23-,24?,27-,29+,30-,31+,32-/m1/s1
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Rhodes Technologies

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Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM222962
PNG
(US9315514, 6)
Show SMILES CC(C)(C)[C@@]1(C)OC(O[C@]23CC[C@@]4(C[C@H]12)[C@H]1Cc2ccc(O)c5O[C@@H]3[C@]4(CCN1CC1CC1)c25)c1ccccc1
Show InChI InChI=1S/C35H43NO4/c1-31(2,3)32(4)25-19-33-14-15-35(25,40-29(39-32)22-8-6-5-7-9-22)30-34(33)16-17-36(20-21-10-11-21)26(33)18-23-12-13-24(37)28(38-30)27(23)34/h5-9,12-13,21,25-26,29-30,37H,10-11,14-20H2,1-4H3/t25-,26-,29?,30-,32+,33-,34+,35-/m1/s1
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Rhodes Technologies

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Assay Description
Radioligand dose-displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membr...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222962
PNG
(US9315514, 6)
Show SMILES CC(C)(C)[C@@]1(C)OC(O[C@]23CC[C@@]4(C[C@H]12)[C@H]1Cc2ccc(O)c5O[C@@H]3[C@]4(CCN1CC1CC1)c25)c1ccccc1
Show InChI InChI=1S/C35H43NO4/c1-31(2,3)32(4)25-19-33-14-15-35(25,40-29(39-32)22-8-6-5-7-9-22)30-34(33)16-17-36(20-21-10-11-21)26(33)18-23-12-13-24(37)28(38-30)27(23)34/h5-9,12-13,21,25-26,29-30,37H,10-11,14-20H2,1-4H3/t25-,26-,29?,30-,32+,33-,34+,35-/m1/s1
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Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222965
PNG
(US9315514, 8)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@@]12CC[C@@]35C[C@@H]1[C@](C)(OCO2)C(C)(C)C
Show InChI InChI=1S/C30H41NO4/c1-26(2,3)27(4)21-15-28-10-11-30(21,34-17-33-27)25-29(28)12-13-31(16-18-6-7-18)22(28)14-19-8-9-20(32-5)24(35-25)23(19)29/h8-9,18,21-22,25H,6-7,10-17H2,1-5H3/t21-,22-,25-,27+,28-,29+,30-/m1/s1
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Rhodes Technologies

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222964
PNG
(US9315514, 12)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@]12OCO[C@@](C)([C@H]1C[C@]35C=C2)C(C)(C)C
Show InChI InChI=1S/C30H39NO4/c1-26(2,3)27(4)21-15-28-10-11-30(21,34-17-33-27)25-29(28)12-13-31(16-18-6-7-18)22(28)14-19-8-9-20(32-5)24(35-25)23(19)29/h8-11,18,21-22,25H,6-7,12-17H2,1-5H3/t21-,22-,25-,27+,28-,29+,30-/m1/s1
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Rhodes Technologies

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222966
PNG
(US9315514, 7)
Show SMILES CC(C)(C)[C@@]1(C)OCO[C@]23CC[C@@]4(C[C@H]12)[C@H]1Cc2ccc(OCc5ccccc5)c5O[C@@H]3[C@]4(CCN1CC1CC1)c25
Show InChI InChI=1S/C36H45NO4/c1-32(2,3)33(4)27-19-34-14-15-36(27,40-22-39-33)31-35(34)16-17-37(20-23-10-11-23)28(34)18-25-12-13-26(30(41-31)29(25)35)38-21-24-8-6-5-7-9-24/h5-9,12-13,23,27-28,31H,10-11,14-22H2,1-4H3/t27-,28-,31-,33+,34-,35+,36-/m1/s1
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Rhodes Technologies

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222960
PNG
(US9315514, 4)
Show SMILES CCC1O[C@@](C)([C@H]2C[C@]34CC[C@]2(O1)[C@@H]1Oc2c5c(C[C@H]3N(CC3CC3)CC[C@@]415)ccc2O)C(C)(C)C
Show InChI InChI=1S/C31H43NO4/c1-6-23-35-28(5,27(2,3)4)21-16-29-11-12-31(21,36-23)26-30(29)13-14-32(17-18-7-8-18)22(29)15-19-9-10-20(33)25(34-26)24(19)30/h9-10,18,21-23,26,33H,6-8,11-17H2,1-5H3/t21-,22-,23?,26-,28+,29-,30+,31-/m1/s1
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n/an/an/an/a 4.42n/an/an/an/a



Rhodes Technologies

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222963
PNG
(US9315514, 11)
Show InChI InChI=1S/C29H37NO4/c1-25(2,3)26(4)20-14-27-9-10-29(20,33-16-32-26)24-28(27)11-12-30(15-17-5-6-17)21(27)13-18-7-8-19(31)23(34-24)22(18)28/h7-10,17,20-21,24,31H,5-6,11-16H2,1-4H3/t20-,21-,24-,26+,27-,28+,29-/m1/s1
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n/an/an/an/a 7.76n/an/an/an/a



Rhodes Technologies

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222964
PNG
(US9315514, 12)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@]12OCO[C@@](C)([C@H]1C[C@]35C=C2)C(C)(C)C
Show InChI InChI=1S/C30H39NO4/c1-26(2,3)27(4)21-15-28-10-11-30(21,34-17-33-27)25-29(28)12-13-31(16-18-6-7-18)22(28)14-19-8-9-20(32-5)24(35-25)23(19)29/h8-11,18,21-22,25H,6-7,12-17H2,1-5H3/t21-,22-,25-,27+,28-,29+,30-/m1/s1
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n/an/an/an/a 593n/an/an/an/a



Rhodes Technologies

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM222966
PNG
(US9315514, 7)
Show SMILES CC(C)(C)[C@@]1(C)OCO[C@]23CC[C@@]4(C[C@H]12)[C@H]1Cc2ccc(OCc5ccccc5)c5O[C@@H]3[C@]4(CCN1CC1CC1)c25
Show InChI InChI=1S/C36H45NO4/c1-32(2,3)33(4)27-19-34-14-15-36(27,40-22-39-33)31-35(34)16-17-37(20-23-10-11-23)28(34)18-25-12-13-26(30(41-31)29(25)35)38-21-24-8-6-5-7-9-24/h5-9,12-13,23,27-28,31H,10-11,14-22H2,1-4H3/t27-,28-,31-,33+,34-,35+,36-/m1/s1
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Rhodes Technologies

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared in-house from a cell line expressing recombin...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM222962
PNG
(US9315514, 6)
Show SMILES CC(C)(C)[C@@]1(C)OC(O[C@]23CC[C@@]4(C[C@H]12)[C@H]1Cc2ccc(O)c5O[C@@H]3[C@]4(CCN1CC1CC1)c25)c1ccccc1
Show InChI InChI=1S/C35H43NO4/c1-31(2,3)32(4)25-19-33-14-15-35(25,40-29(39-32)22-8-6-5-7-9-22)30-34(33)16-17-36(20-21-10-11-21)26(33)18-23-12-13-24(37)28(38-30)27(23)34/h5-9,12-13,21,25-26,29-30,37H,10-11,14-20H2,1-4H3/t25-,26-,29?,30-,32+,33-,34+,35-/m1/s1
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n/an/an/an/a 5.35n/an/an/an/a



Rhodes Technologies

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared in-house from a cell line expressing recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222966
PNG
(US9315514, 7)
Show SMILES CC(C)(C)[C@@]1(C)OCO[C@]23CC[C@@]4(C[C@H]12)[C@H]1Cc2ccc(OCc5ccccc5)c5O[C@@H]3[C@]4(CCN1CC1CC1)c25
Show InChI InChI=1S/C36H45NO4/c1-32(2,3)33(4)27-19-34-14-15-36(27,40-22-39-33)31-35(34)16-17-37(20-23-10-11-23)28(34)18-25-12-13-26(30(41-31)29(25)35)38-21-24-8-6-5-7-9-24/h5-9,12-13,23,27-28,31H,10-11,14-22H2,1-4H3/t27-,28-,31-,33+,34-,35+,36-/m1/s1
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n/an/an/an/a>2.00E+4n/an/an/an/a



Rhodes Technologies

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222961
PNG
(US9315514, 5)
Show SMILES CCCC1O[C@@](C)([C@H]2C[C@]34CC[C@]2(O1)[C@@H]1Oc2c5c(C[C@H]3N(CC3CC3)CC[C@@]415)ccc2O)C(C)(C)C
Show InChI InChI=1S/C32H45NO4/c1-6-7-24-36-29(5,28(2,3)4)22-17-30-12-13-32(22,37-24)27-31(30)14-15-33(18-19-8-9-19)23(30)16-20-10-11-21(34)26(35-27)25(20)31/h10-11,19,22-24,27,34H,6-9,12-18H2,1-5H3/t22-,23-,24?,27-,29+,30-,31+,32-/m1/s1
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Rhodes Technologies

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM222961
PNG
(US9315514, 5)
Show SMILES CCCC1O[C@@](C)([C@H]2C[C@]34CC[C@]2(O1)[C@@H]1Oc2c5c(C[C@H]3N(CC3CC3)CC[C@@]415)ccc2O)C(C)(C)C
Show InChI InChI=1S/C32H45NO4/c1-6-7-24-36-29(5,28(2,3)4)22-17-30-12-13-32(22,37-24)27-31(30)14-15-33(18-19-8-9-19)23(30)16-20-10-11-21(34)26(35-27)25(20)31/h10-11,19,22-24,27,34H,6-9,12-18H2,1-5H3/t22-,23-,24?,27-,29+,30-,31+,32-/m1/s1
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Rhodes Technologies

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared in-house from a cell line expressing recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50354578
PNG
(BUPRENORPHINE | US9315514, Buprenorphine)
Show SMILES CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45
Show InChI InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29+/m1/s1
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n/an/an/an/a 0.560n/an/an/an/a



Rhodes Technologies

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM222964
PNG
(US9315514, 12)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@]12OCO[C@@](C)([C@H]1C[C@]35C=C2)C(C)(C)C
Show InChI InChI=1S/C30H39NO4/c1-26(2,3)27(4)21-15-28-10-11-30(21,34-17-33-27)25-29(28)12-13-31(16-18-6-7-18)22(28)14-19-8-9-20(32-5)24(35-25)23(19)29/h8-11,18,21-22,25H,6-7,12-17H2,1-5H3/t21-,22-,25-,27+,28-,29+,30-/m1/s1
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Rhodes Technologies

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared in-house from a cell line expressing recombin...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM222960
PNG
(US9315514, 4)
Show SMILES CCC1O[C@@](C)([C@H]2C[C@]34CC[C@]2(O1)[C@@H]1Oc2c5c(C[C@H]3N(CC3CC3)CC[C@@]415)ccc2O)C(C)(C)C
Show InChI InChI=1S/C31H43NO4/c1-6-23-35-28(5,27(2,3)4)21-16-29-11-12-31(21,36-23)26-30(29)13-14-32(17-18-7-8-18)22(29)15-19-9-10-20(33)25(34-26)24(19)30/h9-10,18,21-23,26,33H,6-8,11-17H2,1-5H3/t21-,22-,23?,26-,28+,29-,30+,31-/m1/s1
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Rhodes Technologies

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared in-house from a cell line expressing recombin...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM222959
PNG
(US9315514, 3)
Show SMILES CC(C)(C)[C@@]1(C)OCO[C@]23CC[C@@]4(C[C@H]12)[C@H]1Cc2ccc(O)c5O[C@@H]3[C@]4(CCN1CC1CC1)c25
Show InChI InChI=1S/C29H39NO4/c1-25(2,3)26(4)20-14-27-9-10-29(20,33-16-32-26)24-28(27)11-12-30(15-17-5-6-17)21(27)13-18-7-8-19(31)23(34-24)22(18)28/h7-8,17,20-21,24,31H,5-6,9-16H2,1-4H3/t20-,21-,24-,26+,27-,28+,29-/m1/s1
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Rhodes Technologies

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared in-house from a cell line expressing recombin...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50354578
PNG
(BUPRENORPHINE | US9315514, Buprenorphine)
Show SMILES CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45
Show InChI InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29+/m1/s1
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n/an/an/an/a 0.450n/an/an/an/a



Rhodes Technologies

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared in-house from a cell line expressing recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222962
PNG
(US9315514, 6)
Show SMILES CC(C)(C)[C@@]1(C)OC(O[C@]23CC[C@@]4(C[C@H]12)[C@H]1Cc2ccc(O)c5O[C@@H]3[C@]4(CCN1CC1CC1)c25)c1ccccc1
Show InChI InChI=1S/C35H43NO4/c1-31(2,3)32(4)25-19-33-14-15-35(25,40-29(39-32)22-8-6-5-7-9-22)30-34(33)16-17-36(20-21-10-11-21)26(33)18-23-12-13-24(37)28(38-30)27(23)34/h5-9,12-13,21,25-26,29-30,37H,10-11,14-20H2,1-4H3/t25-,26-,29?,30-,32+,33-,34+,35-/m1/s1
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Rhodes Technologies

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222959
PNG
(US9315514, 3)
Show SMILES CC(C)(C)[C@@]1(C)OCO[C@]23CC[C@@]4(C[C@H]12)[C@H]1Cc2ccc(O)c5O[C@@H]3[C@]4(CCN1CC1CC1)c25
Show InChI InChI=1S/C29H39NO4/c1-25(2,3)26(4)20-14-27-9-10-29(20,33-16-32-26)24-28(27)11-12-30(15-17-5-6-17)21(27)13-18-7-8-19(31)23(34-24)22(18)28/h7-8,17,20-21,24,31H,5-6,9-16H2,1-4H3/t20-,21-,24-,26+,27-,28+,29-/m1/s1
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Rhodes Technologies

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM222965
PNG
(US9315514, 8)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@@]12CC[C@@]35C[C@@H]1[C@](C)(OCO2)C(C)(C)C
Show InChI InChI=1S/C30H41NO4/c1-26(2,3)27(4)21-15-28-10-11-30(21,34-17-33-27)25-29(28)12-13-31(16-18-6-7-18)22(28)14-19-8-9-20(32-5)24(35-25)23(19)29/h8-9,18,21-22,25H,6-7,10-17H2,1-5H3/t21-,22-,25-,27+,28-,29+,30-/m1/s1
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Rhodes Technologies

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM222963
PNG
(US9315514, 11)
Show InChI InChI=1S/C29H37NO4/c1-25(2,3)26(4)20-14-27-9-10-29(20,33-16-32-26)24-28(27)11-12-30(15-17-5-6-17)21(27)13-18-7-8-19(31)23(34-24)22(18)28/h7-10,17,20-21,24,31H,5-6,11-16H2,1-4H3/t20-,21-,24-,26+,27-,28+,29-/m1/s1
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Rhodes Technologies

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared in-house from a cell line expressing recombin...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM222965
PNG
(US9315514, 8)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@@]12CC[C@@]35C[C@@H]1[C@](C)(OCO2)C(C)(C)C
Show InChI InChI=1S/C30H41NO4/c1-26(2,3)27(4)21-15-28-10-11-30(21,34-17-33-27)25-29(28)12-13-31(16-18-6-7-18)22(28)14-19-8-9-20(32-5)24(35-25)23(19)29/h8-9,18,21-22,25H,6-7,10-17H2,1-5H3/t21-,22-,25-,27+,28-,29+,30-/m1/s1
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Rhodes Technologies

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared in-house from a cell line expressing recombin...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%