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Patent code US9321748

Compile Data Set for Download or QSAR
Found 59 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223558
PNG
(US9321748, 18)
Show SMILES COc1cc(ccc1CN1CCOCC1)-c1cnc(N)c(c1)-c1cn(nn1)C(C)C
Show InChI InChI=1S/C22H28N6O2/c1-15(2)28-14-20(25-26-28)19-10-18(12-24-22(19)23)16-4-5-17(21(11-16)29-3)13-27-6-8-30-9-7-27/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H2,23,24)
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n/an/a 86n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223557
PNG
(US9321748, 17)
Show SMILES COc1cc(ccc1C(=O)N1CCOCC1)-c1cnc(N)c(c1)-c1cn(nn1)C(C)C
Show InChI InChI=1S/C22H26N6O3/c1-14(2)28-13-19(25-26-28)18-10-16(12-24-21(18)23)15-4-5-17(20(11-15)30-3)22(29)27-6-8-31-9-7-27/h4-5,10-14H,6-9H2,1-3H3,(H2,23,24)
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US Patent
n/an/a 91n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223558
PNG
(US9321748, 18)
Show SMILES COc1cc(ccc1CN1CCOCC1)-c1cnc(N)c(c1)-c1cn(nn1)C(C)C
Show InChI InChI=1S/C22H28N6O2/c1-15(2)28-14-20(25-26-28)19-10-18(12-24-22(19)23)16-4-5-17(21(11-16)29-3)13-27-6-8-30-9-7-27/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H2,23,24)
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n/an/a 93n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223557
PNG
(US9321748, 17)
Show SMILES COc1cc(ccc1C(=O)N1CCOCC1)-c1cnc(N)c(c1)-c1cn(nn1)C(C)C
Show InChI InChI=1S/C22H26N6O3/c1-14(2)28-13-19(25-26-28)18-10-16(12-24-21(18)23)15-4-5-17(20(11-15)30-3)22(29)27-6-8-31-9-7-27/h4-5,10-14H,6-9H2,1-3H3,(H2,23,24)
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n/an/a 95n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223560
PNG
(US9321748, 20)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(C(=O)N2CCOCC2)c(C)c1
Show InChI InChI=1S/C22H26N6O2/c1-14(2)28-13-20(25-26-28)19-11-17(12-24-21(19)23)16-4-5-18(15(3)10-16)22(29)27-6-8-30-9-7-27/h4-5,10-14H,6-9H2,1-3H3,(H2,23,24)
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n/an/a 99n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223560
PNG
(US9321748, 20)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(C(=O)N2CCOCC2)c(C)c1
Show InChI InChI=1S/C22H26N6O2/c1-14(2)28-13-20(25-26-28)19-11-17(12-24-21(19)23)16-4-5-18(15(3)10-16)22(29)27-6-8-30-9-7-27/h4-5,10-14H,6-9H2,1-3H3,(H2,23,24)
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n/an/a 110n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223552
PNG
(US9321748, 12)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C21H26N6O/c1-15(2)27-14-20(24-25-27)19-11-18(12-23-21(19)22)17-5-3-16(4-6-17)13-26-7-9-28-10-8-26/h3-6,11-12,14-15H,7-10,13H2,1-2H3,(H2,22,23)
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n/an/a 160n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223555
PNG
(US9321748, 15)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(CN2CCOCC2)c(F)c1
Show InChI InChI=1S/C21H25FN6O/c1-14(2)28-13-20(25-26-28)18-9-17(11-24-21(18)23)15-3-4-16(19(22)10-15)12-27-5-7-29-8-6-27/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H2,23,24)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223563
PNG
(US9321748, 23)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(CN2CCOCC2)c(Cl)c1
Show InChI InChI=1S/C21H25ClN6O/c1-14(2)28-13-20(25-26-28)18-9-17(11-24-21(18)23)15-3-4-16(19(22)10-15)12-27-5-7-29-8-6-27/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H2,23,24)
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n/an/a 220n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223561
PNG
(US9321748, 21)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(CN2CCOCC2)c(C)c1
Show InChI InChI=1S/C22H28N6O/c1-15(2)28-14-21(25-26-28)20-11-19(12-24-22(20)23)17-4-5-18(16(3)10-17)13-27-6-8-29-9-7-27/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H2,23,24)
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n/an/a 240n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223561
PNG
(US9321748, 21)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(CN2CCOCC2)c(C)c1
Show InChI InChI=1S/C22H28N6O/c1-15(2)28-14-21(25-26-28)20-11-19(12-24-22(20)23)17-4-5-18(16(3)10-17)13-27-6-8-29-9-7-27/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H2,23,24)
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n/an/a 260n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223553
PNG
(US9321748, 13)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C20H24N6O/c1-14(2)26-13-19(23-24-26)18-11-16(12-22-20(18)21)15-3-5-17(6-4-15)25-7-9-27-10-8-25/h3-6,11-14H,7-10H2,1-2H3,(H2,21,22)
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n/an/a 280n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223562
PNG
(US9321748, 22)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(C(=O)N2CCOCC2)c(Cl)c1
Show InChI InChI=1S/C21H23ClN6O2/c1-13(2)28-12-19(25-26-28)17-9-15(11-24-20(17)23)14-3-4-16(18(22)10-14)21(29)27-5-7-30-8-6-27/h3-4,9-13H,5-8H2,1-2H3,(H2,23,24)
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n/an/a 290n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223562
PNG
(US9321748, 22)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(C(=O)N2CCOCC2)c(Cl)c1
Show InChI InChI=1S/C21H23ClN6O2/c1-13(2)28-12-19(25-26-28)17-9-15(11-24-20(17)23)14-3-4-16(18(22)10-14)21(29)27-5-7-30-8-6-27/h3-4,9-13H,5-8H2,1-2H3,(H2,23,24)
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n/an/a 290n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223552
PNG
(US9321748, 12)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C21H26N6O/c1-15(2)27-14-20(24-25-27)19-11-18(12-23-21(19)22)17-5-3-16(4-6-17)13-26-7-9-28-10-8-26/h3-6,11-12,14-15H,7-10,13H2,1-2H3,(H2,22,23)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223563
PNG
(US9321748, 23)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(CN2CCOCC2)c(Cl)c1
Show InChI InChI=1S/C21H25ClN6O/c1-14(2)28-13-20(25-26-28)18-9-17(11-24-21(18)23)15-3-4-16(19(22)10-15)12-27-5-7-29-8-6-27/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H2,23,24)
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n/an/a 320n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223553
PNG
(US9321748, 13)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C20H24N6O/c1-14(2)26-13-19(23-24-26)18-11-16(12-22-20(18)21)15-3-5-17(6-4-15)25-7-9-27-10-8-25/h3-6,11-14H,7-10H2,1-2H3,(H2,21,22)
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n/an/a 340n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223551
PNG
(US9321748, 11)
Show SMILES CC(C)n1cc(nn1)-c1nc(cnc1N)-c1ccc2N(C)CCc2c1
Show InChI InChI=1S/C18H21N7/c1-11(2)25-10-15(22-23-25)17-18(19)20-9-14(21-17)12-4-5-16-13(8-12)6-7-24(16)3/h4-5,8-11H,6-7H2,1-3H3,(H2,19,20)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223554
PNG
(US9321748, 14)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(CCN2CCOCC2)cc1
Show InChI InChI=1S/C22H28N6O/c1-16(2)28-15-21(25-26-28)20-13-19(14-24-22(20)23)18-5-3-17(4-6-18)7-8-27-9-11-29-12-10-27/h3-6,13-16H,7-12H2,1-2H3,(H2,23,24)
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n/an/a 340n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223550
PNG
(US9321748, 10)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc2N(C)CCc2c1
Show InChI InChI=1S/C19H22N6/c1-12(2)25-11-17(22-23-25)16-9-15(10-21-19(16)20)13-4-5-18-14(8-13)6-7-24(18)3/h4-5,8-12H,6-7H2,1-3H3,(H2,20,21)
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n/an/a 350n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223564
PNG
(US9321748, 24)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1cccc(CN2CCOCC2)c1
Show InChI InChI=1S/C21H26N6O/c1-15(2)27-14-20(24-25-27)19-11-18(12-23-21(19)22)17-5-3-4-16(10-17)13-26-6-8-28-9-7-26/h3-5,10-12,14-15H,6-9,13H2,1-2H3,(H2,22,23)
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n/an/a 370n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223568
PNG
(US9321748, 28)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H24N6O2/c1-14(2)27-13-19(24-25-27)18-11-17(12-23-20(18)22)15-3-5-16(6-4-15)21(28)26-7-9-29-10-8-26/h3-6,11-14H,7-10H2,1-2H3,(H2,22,23)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223555
PNG
(US9321748, 15)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(CN2CCOCC2)c(F)c1
Show InChI InChI=1S/C21H25FN6O/c1-14(2)28-13-20(25-26-28)18-9-17(11-24-21(18)23)15-3-4-16(19(22)10-15)12-27-5-7-29-8-6-27/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H2,23,24)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223545
PNG
(US9321748, 5)
Show SMILES CN1CCc2cc(ccc12)-c1cnc(N)c(c1)-c1nnc(o1)C1CCNCC1
Show InChI InChI=1S/C21H24N6O/c1-27-9-6-15-10-14(2-3-18(15)27)16-11-17(19(22)24-12-16)21-26-25-20(28-21)13-4-7-23-8-5-13/h2-3,10-13,23H,4-9H2,1H3,(H2,22,24)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223546
PNG
(US9321748, 6)
Show SMILES Nc1ncc(cc1-c1nnc(o1)C1CC1)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C21H23N5O2/c22-19-18(21-25-24-20(28-21)16-5-6-16)11-17(12-23-19)15-3-1-14(2-4-15)13-26-7-9-27-10-8-26/h1-4,11-12,16H,5-10,13H2,(H2,22,23)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223568
PNG
(US9321748, 28)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H24N6O2/c1-14(2)27-13-19(24-25-27)18-11-17(12-23-20(18)22)15-3-5-16(6-4-15)21(28)26-7-9-29-10-8-26/h3-6,11-14H,7-10H2,1-2H3,(H2,22,23)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223546
PNG
(US9321748, 6)
Show SMILES Nc1ncc(cc1-c1nnc(o1)C1CC1)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C21H23N5O2/c22-19-18(21-25-24-20(28-21)16-5-6-16)11-17(12-23-19)15-3-1-14(2-4-15)13-26-7-9-27-10-8-26/h1-4,11-12,16H,5-10,13H2,(H2,22,23)
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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223566
PNG
(US9321748, 26)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1cc(Cl)cc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H23ClN6O2/c1-13(2)28-12-19(25-26-28)18-10-16(11-24-20(18)23)14-7-15(9-17(22)8-14)21(29)27-3-5-30-6-4-27/h7-13H,3-6H2,1-2H3,(H2,23,24)
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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223564
PNG
(US9321748, 24)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1cccc(CN2CCOCC2)c1
Show InChI InChI=1S/C21H26N6O/c1-15(2)27-14-20(24-25-27)19-11-18(12-23-21(19)22)17-5-3-4-16(10-17)13-26-6-8-28-9-7-26/h3-5,10-12,14-15H,6-9,13H2,1-2H3,(H2,22,23)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223556
PNG
(US9321748, 16)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(C(=O)N2CCOCC2)c(F)c1
Show InChI InChI=1S/C21H23FN6O2/c1-13(2)28-12-19(25-26-28)17-9-15(11-24-20(17)23)14-3-4-16(18(22)10-14)21(29)27-5-7-30-8-6-27/h3-4,9-13H,5-8H2,1-2H3,(H2,23,24)
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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223570
PNG
(US9321748, 30)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(CC(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C22H26N6O2/c1-15(2)28-14-20(25-26-28)19-12-18(13-24-22(19)23)17-5-3-16(4-6-17)11-21(29)27-7-9-30-10-8-27/h3-6,12-15H,7-11H2,1-2H3,(H2,23,24)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223549
PNG
(US9321748, 9)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C19H20N6/c1-12(2)25-11-17(22-23-25)16-9-15(10-21-19(16)20)13-4-5-18-14(8-13)6-7-24(18)3/h4-12H,1-3H3,(H2,20,21)
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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223549
PNG
(US9321748, 9)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C19H20N6/c1-12(2)25-11-17(22-23-25)16-9-15(10-21-19(16)20)13-4-5-18-14(8-13)6-7-24(18)3/h4-12H,1-3H3,(H2,20,21)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223542
PNG
(US9321748, 2)
Show SMILES Nc1ncc(cc1-c1nnc(o1)C1CC1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C18H15N5O/c19-16-14(18-23-22-17(24-18)10-1-2-10)8-13(9-21-16)11-3-4-15-12(7-11)5-6-20-15/h3-10,20H,1-2H2,(H2,19,21)
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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223551
PNG
(US9321748, 11)
Show SMILES CC(C)n1cc(nn1)-c1nc(cnc1N)-c1ccc2N(C)CCc2c1
Show InChI InChI=1S/C18H21N7/c1-11(2)25-10-15(22-23-25)17-18(19)20-9-14(21-17)12-4-5-16-13(8-12)6-7-24(16)3/h4-5,8-11H,6-7H2,1-3H3,(H2,19,20)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223556
PNG
(US9321748, 16)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(C(=O)N2CCOCC2)c(F)c1
Show InChI InChI=1S/C21H23FN6O2/c1-13(2)28-12-19(25-26-28)17-9-15(11-24-20(17)23)14-3-4-16(18(22)10-14)21(29)27-5-7-30-8-6-27/h3-4,9-13H,5-8H2,1-2H3,(H2,23,24)
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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223554
PNG
(US9321748, 14)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(CCN2CCOCC2)cc1
Show InChI InChI=1S/C22H28N6O/c1-16(2)28-15-21(25-26-28)20-13-19(14-24-22(20)23)18-5-3-17(4-6-18)7-8-27-9-11-29-12-10-27/h3-6,13-16H,7-12H2,1-2H3,(H2,23,24)
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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223567
PNG
(US9321748, 27)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1cc(Cl)cc(CN2CCOCC2)c1
Show InChI InChI=1S/C21H25ClN6O/c1-14(2)28-13-20(25-26-28)19-10-17(11-24-21(19)23)16-7-15(8-18(22)9-16)12-27-3-5-29-6-4-27/h7-11,13-14H,3-6,12H2,1-2H3,(H2,23,24)
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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223550
PNG
(US9321748, 10)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc2N(C)CCc2c1
Show InChI InChI=1S/C19H22N6/c1-12(2)25-11-17(22-23-25)16-9-15(10-21-19(16)20)13-4-5-18-14(8-13)6-7-24(18)3/h4-5,8-12H,6-7H2,1-3H3,(H2,20,21)
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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223565
PNG
(US9321748, 25)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1cccc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H24N6O2/c1-14(2)27-13-19(24-25-27)18-11-17(12-23-20(18)22)15-4-3-5-16(10-15)21(28)26-6-8-29-9-7-26/h3-5,10-14H,6-9H2,1-2H3,(H2,22,23)
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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223570
PNG
(US9321748, 30)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(CC(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C22H26N6O2/c1-15(2)28-14-20(25-26-28)19-12-18(13-24-22(19)23)17-5-3-16(4-6-17)11-21(29)27-7-9-30-10-8-27/h3-6,12-15H,7-11H2,1-2H3,(H2,23,24)
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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223566
PNG
(US9321748, 26)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1cc(Cl)cc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H23ClN6O2/c1-13(2)28-12-19(25-26-28)18-10-16(11-24-20(18)23)14-7-15(9-17(22)8-14)21(29)27-3-5-30-6-4-27/h7-13H,3-6H2,1-2H3,(H2,23,24)
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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223543
PNG
(US9321748, 3)
Show SMILES CN1CCc2cc(ccc12)-c1cnc(N)c(c1)-c1nnc(o1)C1CC1
Show InChI InChI=1S/C19H19N5O/c1-24-7-6-13-8-12(4-5-16(13)24)14-9-15(17(20)21-10-14)19-23-22-18(25-19)11-2-3-11/h4-5,8-11H,2-3,6-7H2,1H3,(H2,20,21)
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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223569
PNG
(US9321748, 29)
Show SMILES Nc1ncc(cc1-c1nnc(o1)C1CC1)-c1cccc(CN2CCOCC2)c1
Show InChI InChI=1S/C21H23N5O2/c22-19-18(21-25-24-20(28-21)15-4-5-15)11-17(12-23-19)16-3-1-2-14(10-16)13-26-6-8-27-9-7-26/h1-3,10-12,15H,4-9,13H2,(H2,22,23)
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n/an/a 760n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223567
PNG
(US9321748, 27)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1cc(Cl)cc(CN2CCOCC2)c1
Show InChI InChI=1S/C21H25ClN6O/c1-14(2)28-13-20(25-26-28)19-10-17(11-24-21(19)23)16-7-15(8-18(22)9-16)12-27-3-5-29-6-4-27/h7-11,13-14H,3-6,12H2,1-2H3,(H2,23,24)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223544
PNG
(US9321748, 4)
Show SMILES CN1CCC(CC1)c1nnc(o1)-c1cc(cnc1N)-c1ccc(C)cc1
Show InChI InChI=1S/C20H23N5O/c1-13-3-5-14(6-4-13)16-11-17(18(21)22-12-16)20-24-23-19(26-20)15-7-9-25(2)10-8-15/h3-6,11-12,15H,7-10H2,1-2H3,(H2,21,22)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223548
PNG
(US9321748, 8)
Show SMILES COc1cccc(c1)-c1cnc(N)c(c1)-c1nnc(o1)C1CCN(C)CC1
Show InChI InChI=1S/C20H23N5O2/c1-25-8-6-13(7-9-25)19-23-24-20(27-19)17-11-15(12-22-18(17)21)14-4-3-5-16(10-14)26-2/h3-5,10-13H,6-9H2,1-2H3,(H2,21,22)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223559
PNG
(US9321748, 19)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(F)c(CN2CCOCC2)c1
Show InChI InChI=1S/C21H25FN6O/c1-14(2)28-13-20(25-26-28)18-10-16(11-24-21(18)23)15-3-4-19(22)17(9-15)12-27-5-7-29-8-6-27/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H2,23,24)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


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More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223569
PNG
(US9321748, 29)
Show SMILES Nc1ncc(cc1-c1nnc(o1)C1CC1)-c1cccc(CN2CCOCC2)c1
Show InChI InChI=1S/C21H23N5O2/c22-19-18(21-25-24-20(28-21)15-4-5-15)11-17(12-23-19)16-3-1-2-14(10-16)13-26-6-8-27-9-7-26/h1-3,10-12,15H,4-9,13H2,(H2,22,23)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223541
PNG
(US9321748, 1)
Show SMILES CC(C)c1nnc(o1)-c1cc(cnc1N)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C18H17N5O/c1-10(2)17-22-23-18(24-17)14-8-13(9-21-16(14)19)11-3-4-15-12(7-11)5-6-20-15/h3-10,20H,1-2H3,(H2,19,21)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223565
PNG
(US9321748, 25)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1cccc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H24N6O2/c1-14(2)27-13-19(24-25-27)18-11-17(12-23-20(18)22)15-4-3-5-16(10-15)21(28)26-6-8-29-9-7-26/h3-5,10-14H,6-9H2,1-2H3,(H2,22,23)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

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Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223543
PNG
(US9321748, 3)
Show SMILES CN1CCc2cc(ccc12)-c1cnc(N)c(c1)-c1nnc(o1)C1CC1
Show InChI InChI=1S/C19H19N5O/c1-24-7-6-13-8-12(4-5-16(13)24)14-9-15(17(20)21-10-14)19-23-22-18(25-19)11-2-3-11/h4-5,8-11H,2-3,6-7H2,1H3,(H2,20,21)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223559
PNG
(US9321748, 19)
Show SMILES CC(C)n1cc(nn1)-c1cc(cnc1N)-c1ccc(F)c(CN2CCOCC2)c1
Show InChI InChI=1S/C21H25FN6O/c1-14(2)28-13-20(25-26-28)18-10-16(11-24-21(18)23)15-3-4-19(22)17(9-15)12-27-5-7-29-8-6-27/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H2,23,24)
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n/an/a 1.00E+3n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223542
PNG
(US9321748, 2)
Show SMILES Nc1ncc(cc1-c1nnc(o1)C1CC1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C18H15N5O/c19-16-14(18-23-22-17(24-18)10-1-2-10)8-13(9-21-16)11-3-4-15-12(7-11)5-6-20-15/h3-10,20H,1-2H2,(H2,19,21)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM223547
PNG
(US9321748, 7)
Show SMILES COc1cccc(c1)-c1cnc(N)c(c1)-c1nnc(o1)C1CCNCC1
Show InChI InChI=1S/C19H21N5O2/c1-25-15-4-2-3-13(9-15)14-10-16(17(20)22-11-14)19-24-23-18(26-19)12-5-7-21-8-6-12/h2-4,9-12,21H,5-8H2,1H3,(H2,20,22)
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H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223545
PNG
(US9321748, 5)
Show SMILES CN1CCc2cc(ccc12)-c1cnc(N)c(c1)-c1nnc(o1)C1CCNCC1
Show InChI InChI=1S/C21H24N6O/c1-27-9-6-15-10-14(2-3-18(15)27)16-11-17(19(22)24-12-16)21-26-25-20(28-21)13-4-7-23-8-5-13/h2-3,10-13,23H,4-9H2,1H3,(H2,22,24)
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n/an/a 2.20E+3n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223548
PNG
(US9321748, 8)
Show SMILES COc1cccc(c1)-c1cnc(N)c(c1)-c1nnc(o1)C1CCN(C)CC1
Show InChI InChI=1S/C20H23N5O2/c1-25-8-6-13(7-9-25)19-23-24-20(27-19)17-11-15(12-22-18(17)21)14-4-3-5-16(10-14)26-2/h3-5,10-13H,6-9H2,1-2H3,(H2,21,22)
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n/an/a 2.20E+3n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223547
PNG
(US9321748, 7)
Show SMILES COc1cccc(c1)-c1cnc(N)c(c1)-c1nnc(o1)C1CCNCC1
Show InChI InChI=1S/C19H21N5O2/c1-25-15-4-2-3-13(9-15)14-10-16(17(20)22-11-14)19-24-23-18(26-19)12-5-7-21-8-6-12/h2-4,9-12,21H,5-8H2,1H3,(H2,20,22)
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n/an/a 3.30E+3n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM223544
PNG
(US9321748, 4)
Show SMILES CN1CCC(CC1)c1nnc(o1)-c1cc(cnc1N)-c1ccc(C)cc1
Show InChI InChI=1S/C20H23N5O/c1-13-3-5-14(6-4-13)16-11-17(18(21)22-12-16)20-24-23-19(26-20)15-7-9-25(2)10-8-15/h3-6,11-12,15H,7-10H2,1-2H3,(H2,21,22)
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n/an/a 3.60E+3n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%