BindingDB logo
myBDB logout

Patent code US9321752

Compile Data Set for Download or QSAR
Found 10 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tau


(Homo sapiens (Human))
BDBM223577
PNG
(US9321752, 19-4)
Show SMILES Cn1cccc1\C=C\c1cc(\C=C\c2ccc(OCc3ccccn3)cc2F)n[nH]1
Show InChI InChI=1S/C24H21FN4O/c1-29-14-4-6-22(29)11-10-20-15-19(27-28-20)9-7-18-8-12-23(16-24(18)25)30-17-21-5-2-3-13-26-21/h2-16H,17H2,1H3,(H,27,28)/b9-7+,11-10+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 510n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223578
PNG
(US9321752, 20-3)
Show SMILES Cn1cccc1\C=C\c1cc(\C=C\c2ccc(OCc3ccccn3)cc2)n[nH]1
Show InChI InChI=1S/C24H22N4O/c1-28-16-4-6-23(28)12-11-21-17-20(26-27-21)10-7-19-8-13-24(14-9-19)29-18-22-5-2-3-15-25-22/h2-17H,18H2,1H3,(H,26,27)/b10-7+,12-11+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223580
PNG
(US9321752, 23-2)
Show SMILES COc1cc(OCc2ccccn2)ccc1\C=C\c1cc(\C=C\c2ccc(C)n2C)[nH]n1
Show InChI InChI=1S/C26H26N4O2/c1-19-7-12-24(30(19)2)13-11-22-16-21(28-29-22)10-8-20-9-14-25(17-26(20)31-3)32-18-23-6-4-5-15-27-23/h4-17H,18H2,1-3H3,(H,28,29)/b10-8+,13-11+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 590n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223575
PNG
(US9321752, 16-2)
Show SMILES Cn1ccc2ccc(\C=C\c3cc(\C=C\c4ccc(OCc5ccccn5)cc4F)n[nH]3)cc12
Show InChI InChI=1S/C28H23FN4O/c1-33-15-13-22-7-5-20(16-28(22)33)6-10-23-17-24(32-31-23)11-8-21-9-12-26(18-27(21)29)34-19-25-4-2-3-14-30-25/h2-18H,19H2,1H3,(H,31,32)/b10-6+,11-8+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 600n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223582
PNG
(US9321752, 32-5)
Show SMILES Cc1cc(OCc2ccccn2)ccc1\C=C\c1cc(\C=C\c2cccn2C)[nH]n1
Show InChI InChI=1S/C25H24N4O/c1-19-16-25(30-18-23-6-3-4-14-26-23)13-9-20(19)8-10-21-17-22(28-27-21)11-12-24-7-5-15-29(24)2/h3-17H,18H2,1-2H3,(H,27,28)/b10-8+,12-11+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 640n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223576
PNG
(US9321752, 17-2)
Show SMILES Cn1ccc2ccc(\C=C\c3cc(\C=C\c4ccc(OCc5ccccn5)cc4)n[nH]3)cc12
Show InChI InChI=1S/C28H24N4O/c1-32-17-15-23-10-5-22(18-28(23)32)7-12-25-19-24(30-31-25)11-6-21-8-13-27(14-9-21)33-20-26-4-2-3-16-29-26/h2-19H,20H2,1H3,(H,30,31)/b11-6+,12-7+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223579
PNG
(US9321752, 22-2)
Show SMILES COc1cc(OCc2ccccn2)ccc1\C=C\c1cc(\C=C\c2cccn2C)[nH]n1
Show InChI InChI=1S/C25H24N4O2/c1-29-15-5-7-23(29)12-11-21-16-20(27-28-21)10-8-19-9-13-24(17-25(19)30-2)31-18-22-6-3-4-14-26-22/h3-17H,18H2,1-2H3,(H,27,28)/b10-8+,12-11+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 660n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223583
PNG
(US9321752, 42-2)
Show SMILES COc1cc(OCc2ccccn2)ccc1\C=C\c1cc(\C=C\c2ccnn2C)[nH]n1
Show InChI InChI=1S/C24H23N5O2/c1-29-22(12-14-26-29)10-9-20-15-19(27-28-20)8-6-18-7-11-23(16-24(18)30-2)31-17-21-5-3-4-13-25-21/h3-16H,17H2,1-2H3,(H,27,28)/b8-6+,10-9+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 830n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223581
PNG
(US9321752, 25-2)
Show SMILES COc1cc(OCc2ccccn2)ccc1\C=C\c1cc(\C=C\c2cccc(C)n2)[nH]n1
Show InChI InChI=1S/C26H24N4O2/c1-19-6-5-8-21(28-19)12-13-23-16-22(29-30-23)11-9-20-10-14-25(17-26(20)31-2)32-18-24-7-3-4-15-27-24/h3-17H,18H2,1-2H3,(H,29,30)/b11-9+,13-12+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 840n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223584
PNG
(US9321752, 53-2)
Show SMILES C(CN1CCOCC1)Oc1cccc(\C=C\c2cc(\C=C\c3ccc4cc[nH]c4c3)[nH]n2)c1
Show InChI InChI=1S/C27H28N4O2/c1-2-21(18-26(3-1)33-17-14-31-12-15-32-16-13-31)5-8-24-20-25(30-29-24)9-6-22-4-7-23-10-11-28-27(23)19-22/h1-11,18-20,28H,12-17H2,(H,29,30)/b8-5+,9-6+
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 840n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%