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Patent code US9321756

Compile Data Set for Download or QSAR

Found 823 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224899
PNG
(US9321756, 152)
Show SMILES N[C@H]1CCCCN1c1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C20H21N7S/c21-17-5-1-2-9-27(17)18-6-3-4-16(24-18)14-11-23-15-8-7-12(10-13(14)15)19-25-26-20(22)28-19/h3-4,6-8,10-11,17,23H,1-2,5,9,21H2,(H2,22,26)/t17-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224980
PNG
(US9321756, 247)
Show SMILES C1CC1c1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(NC2CNC2)o1
Show InChI InChI=1S/C20H19N7O/c1-2-11(1)17-9-22-10-18(25-17)15-8-23-16-4-3-12(5-14(15)16)19-26-27-20(28-19)24-13-6-21-7-13/h3-5,8-11,13,21,23H,1-2,6-7H2,(H,24,27)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM225084
PNG
(US9321756, 53)
Show SMILES FC(F)(F)CNc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1
Show InChI InChI=1S/C19H15F3N6O/c20-19(21,22)9-25-18-28-27-17(29-18)11-3-4-15-12(7-11)13(8-24-15)16-23-6-5-14(26-16)10-1-2-10/h3-8,10,24H,1-2,9H2,(H,25,28)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224903
PNG
(US9321756, 155)
Show SMILES Cc1cn(cn1)-c1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C19H15N7S/c1-11-9-26(10-22-11)17-4-2-3-16(23-17)14-8-21-15-6-5-12(7-13(14)15)18-24-25-19(20)27-18/h2-10,21H,1H3,(H2,20,25)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224998
PNG
(US9321756, 264 | US9321756, 265)
Show SMILES CC(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1
Show InChI InChI=1S/C20H20N6O/c1-11(2)23-20-26-25-19(27-20)13-5-6-17-14(9-13)15(10-22-17)18-21-8-7-16(24-18)12-3-4-12/h5-12,22H,3-4H2,1-2H3,(H,23,26)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM225077
PNG
(US9321756, 46)
Show SMILES CC(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(n3)C3CC3)c2c1
Show InChI InChI=1S/C20H20N6O/c1-11(2)23-20-26-25-19(27-20)13-5-6-16-14(7-13)15(8-22-16)18-10-21-9-17(24-18)12-3-4-12/h5-12,22H,3-4H2,1-2H3,(H,23,26)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM225042
PNG
(US9321756, 4)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C19H19N7O/c20-19-26-25-18(27-19)11-5-6-15-13(7-11)14(8-22-15)16-9-21-10-17(24-16)23-12-3-1-2-4-12/h5-10,12,22H,1-4H2,(H2,20,26)(H,23,24)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM225051
PNG
(US9321756, 13)
Show SMILES CN1CCN(CC1)c1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C20H21N7S/c1-26-7-9-27(10-8-26)18-4-2-3-17(23-18)15-12-22-16-6-5-13(11-14(15)16)19-24-25-20(21)28-19/h2-6,11-12,22H,7-10H2,1H3,(H2,21,25)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM225084
PNG
(US9321756, 53)
Show SMILES FC(F)(F)CNc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1
Show InChI InChI=1S/C19H15F3N6O/c20-19(21,22)9-25-18-28-27-17(29-18)11-3-4-15-12(7-11)13(8-24-15)16-23-6-5-14(26-16)10-1-2-10/h3-8,10,24H,1-2,9H2,(H,25,28)
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AMGEN INC.

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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224841
PNG
(US9321756, 100)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(NCC4CC4)n3)c2c1
Show InChI InChI=1S/C18H17N7O/c19-18-25-24-17(26-18)11-3-4-14-12(5-11)13(7-21-14)15-8-20-9-16(23-15)22-6-10-1-2-10/h3-5,7-10,21H,1-2,6H2,(H2,19,25)(H,22,23)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM225039
PNG
(US9321756, 1)
Show SMILES CC1CCCCN1c1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)o1
Show InChI InChI=1S/C20H21N7O/c1-12-4-2-3-7-27(12)18-11-22-10-17(24-18)15-9-23-16-6-5-13(8-14(15)16)19-25-26-20(21)28-19/h5-6,8-12,23H,2-4,7H2,1H3,(H2,21,26)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224873
PNG
(US9321756, 128)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3nccc(n3)N3CCC[C@H](N)C3)c2c1
Show InChI InChI=1S/C20H22N8S/c1-22-20-27-26-19(29-20)12-4-5-16-14(9-12)15(10-24-16)18-23-7-6-17(25-18)28-8-2-3-13(21)11-28/h4-7,9-10,13,24H,2-3,8,11,21H2,1H3,(H,22,27)/t13-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50061613
PNG
(CHEMBL3394164 | US9321756, 17)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C19H19N7S/c20-19-26-25-18(27-19)11-5-6-15-13(7-11)14(8-22-15)16-9-21-10-17(24-16)23-12-3-1-2-4-12/h5-10,12,22H,1-4H2,(H2,20,26)(H,23,24)
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n/an/a 0.763n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224842
PNG
(US9321756, 101)
Show SMILES CC(C)Nc1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)o1
Show InChI InChI=1S/C17H17N7O/c1-9(2)21-15-8-19-7-14(22-15)12-6-20-13-4-3-10(5-11(12)13)16-23-24-17(18)25-16/h3-9,20H,1-2H3,(H2,18,24)(H,21,22)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM225041
PNG
(US9321756, 3)
Show SMILES CC1CCCCN1c1ccnc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)o1
Show InChI InChI=1S/C20H21N7O/c1-12-4-2-3-9-27(12)17-7-8-22-18(24-17)15-11-23-16-6-5-13(10-14(15)16)19-25-26-20(21)28-19/h5-8,10-12,23H,2-4,9H2,1H3,(H2,21,26)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM224835
PNG
(US9321756, 94)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1
Show InChI InChI=1S/C17H14N6O/c18-17-23-22-16(24-17)10-3-4-14-11(7-10)12(8-20-14)15-19-6-5-13(21-15)9-1-2-9/h3-9,20H,1-2H2,(H2,18,23)
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US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224835
PNG
(US9321756, 94)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1
Show InChI InChI=1S/C17H14N6O/c18-17-23-22-16(24-17)10-3-4-14-11(7-10)12(8-20-14)15-19-6-5-13(21-15)9-1-2-9/h3-9,20H,1-2H2,(H2,18,23)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM225042
PNG
(US9321756, 4)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C19H19N7O/c20-19-26-25-18(27-19)11-5-6-15-13(7-11)14(8-22-15)16-9-21-10-17(24-16)23-12-3-1-2-4-12/h5-10,12,22H,1-4H2,(H2,20,26)(H,23,24)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM224980
PNG
(US9321756, 247)
Show SMILES C1CC1c1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(NC2CNC2)o1
Show InChI InChI=1S/C20H19N7O/c1-2-11(1)17-9-22-10-18(25-17)15-8-23-16-4-3-12(5-14(15)16)19-26-27-20(28-19)24-13-6-21-7-13/h3-5,8-11,13,21,23H,1-2,6-7H2,(H,24,27)
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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM225039
PNG
(US9321756, 1)
Show SMILES CC1CCCCN1c1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)o1
Show InChI InChI=1S/C20H21N7O/c1-12-4-2-3-7-27(12)18-11-22-10-17(24-18)15-9-23-16-6-5-13(8-14(15)16)19-25-26-20(21)28-19/h5-6,8-12,23H,2-4,7H2,1H3,(H2,21,26)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM224832
PNG
(US9321756, 91)
Show SMILES C[C@H]1COCCN1c1ccnc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)o1
Show InChI InChI=1S/C19H19N7O2/c1-11-10-27-7-6-26(11)16-4-5-21-17(23-16)14-9-22-15-3-2-12(8-13(14)15)18-24-25-19(20)28-18/h2-5,8-9,11,22H,6-7,10H2,1H3,(H2,20,25)/t11-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM225040
PNG
(US9321756, 2)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(n3)N3CCC(F)(F)CC3)c2c1
Show InChI InChI=1S/C19H17F2N7O/c20-19(21)3-5-28(6-4-19)16-10-23-9-15(25-16)13-8-24-14-2-1-11(7-12(13)14)17-26-27-18(22)29-17/h1-2,7-10,24H,3-6H2,(H2,22,27)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224828
PNG
(US9321756, 87)
Show SMILES CC(C)Oc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)o1
Show InChI InChI=1S/C18H17N5O2/c1-10(2)24-16-5-3-4-15(21-16)13-9-20-14-7-6-11(8-12(13)14)17-22-23-18(19)25-17/h3-10,20H,1-2H3,(H2,19,23)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50061609
PNG
(CHEMBL3394074 | US9321756, 206)
Show SMILES CC(C)Nc1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C17H17N7S/c1-9(2)21-15-8-19-7-14(22-15)12-6-20-13-4-3-10(5-11(12)13)16-23-24-17(18)25-16/h3-9,20H,1-2H3,(H2,18,24)(H,21,22)
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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM225078
PNG
(US9321756, 47)
Show SMILES CC(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3nc(cc(n3)C(O)=O)C3CC3)c2c1
Show InChI InChI=1S/C21H20N6O3/c1-10(2)23-21-27-26-19(30-21)12-5-6-15-13(7-12)14(9-22-15)18-24-16(11-3-4-11)8-17(25-18)20(28)29/h5-11,22H,3-4H2,1-2H3,(H,23,27)(H,28,29)
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AMGEN INC.

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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM224841
PNG
(US9321756, 100)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(NCC4CC4)n3)c2c1
Show InChI InChI=1S/C18H17N7O/c19-18-25-24-17(26-18)11-3-4-14-12(5-11)13(7-21-14)15-8-20-9-16(23-15)22-6-10-1-2-10/h3-5,7-10,21H,1-2,6H2,(H2,19,25)(H,22,23)
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AMGEN INC.

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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM225014
PNG
(US9321756, 281)
Show SMILES CC(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3ncc(C(N)=O)c(n3)C3CC3)c2c1
Show InChI InChI=1S/C21H21N7O2/c1-10(2)25-21-28-27-20(30-21)12-5-6-16-13(7-12)14(8-23-16)19-24-9-15(18(22)29)17(26-19)11-3-4-11/h5-11,23H,3-4H2,1-2H3,(H2,22,29)(H,25,28)
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AMGEN INC.

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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM225033
PNG
(US9321756, 300)
Show SMILES CC(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3cc(=O)[nH]c(n3)C3CC3)c2c1
Show InChI InChI=1S/C20H20N6O2/c1-10(2)22-20-26-25-19(28-20)12-5-6-15-13(7-12)14(9-21-15)16-8-17(27)24-18(23-16)11-3-4-11/h5-11,21H,3-4H2,1-2H3,(H,22,26)(H,23,24,27)
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AMGEN INC.

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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224990
PNG
(US9321756, 256)
Show SMILES C1CC1c1ccnc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(NC2COC2)o1
Show InChI InChI=1S/C20H18N6O2/c1-2-11(1)16-5-6-21-18(24-16)15-8-22-17-4-3-12(7-14(15)17)19-25-26-20(28-19)23-13-9-27-10-13/h3-8,11,13,22H,1-2,9-10H2,(H,23,26)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224838
PNG
(US9321756, 97)
Show SMILES CC1CCCN1c1ccnc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)o1
Show InChI InChI=1S/C19H19N7O/c1-11-3-2-8-26(11)16-6-7-21-17(23-16)14-10-22-15-5-4-12(9-13(14)15)18-24-25-19(20)27-18/h4-7,9-11,22H,2-3,8H2,1H3,(H2,20,25)
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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM225064
PNG
(US9321756, 33)
Show SMILES CC(C)Oc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(s1)N1CC[C@@H](N)C1
Show InChI InChI=1S/C22H24N6OS/c1-13(2)29-20-5-3-4-19(25-20)17-11-24-18-7-6-14(10-16(17)18)21-26-27-22(30-21)28-9-8-15(23)12-28/h3-7,10-11,13,15,24H,8-9,12,23H2,1-2H3/t15-/m1/s1
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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM224980
PNG
(US9321756, 247)
Show SMILES C1CC1c1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(NC2CNC2)o1
Show InChI InChI=1S/C20H19N7O/c1-2-11(1)17-9-22-10-18(25-17)15-8-23-16-4-3-12(5-14(15)16)19-26-27-20(28-19)24-13-6-21-7-13/h3-5,8-11,13,21,23H,1-2,6-7H2,(H,24,27)
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AMGEN INC.

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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM225077
PNG
(US9321756, 46)
Show SMILES CC(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(n3)C3CC3)c2c1
Show InChI InChI=1S/C20H20N6O/c1-11(2)23-20-26-25-19(27-20)13-5-6-16-14(7-13)15(8-22-16)18-10-21-9-17(24-18)12-3-4-12/h5-12,22H,3-4H2,1-2H3,(H,23,26)
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AMGEN INC.

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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM224998
PNG
(US9321756, 264 | US9321756, 265)
Show SMILES CC(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1
Show InChI InChI=1S/C20H20N6O/c1-11(2)23-20-26-25-19(27-20)13-5-6-17-14(9-13)15(10-22-17)18-21-8-7-16(24-18)12-3-4-12/h5-12,22H,3-4H2,1-2H3,(H,23,26)
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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM224998
PNG
(US9321756, 264 | US9321756, 265)
Show SMILES CC(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1
Show InChI InChI=1S/C20H20N6O/c1-11(2)23-20-26-25-19(27-20)13-5-6-17-14(9-13)15(10-22-17)18-21-8-7-16(24-18)12-3-4-12/h5-12,22H,3-4H2,1-2H3,(H,23,26)
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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM224991
PNG
(US9321756, 257)
Show SMILES C1CC1Nc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1
Show InChI InChI=1S/C20H18N6O/c1-2-11(1)16-7-8-21-18(24-16)15-10-22-17-6-3-12(9-14(15)17)19-25-26-20(27-19)23-13-4-5-13/h3,6-11,13,22H,1-2,4-5H2,(H,23,26)
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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224960
PNG
(US9321756, 227)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(n3)N3CCCCC3)c2c1
Show InChI InChI=1S/C20H21N7S/c1-21-20-26-25-19(28-20)13-5-6-16-14(9-13)15(10-23-16)17-11-22-12-18(24-17)27-7-3-2-4-8-27/h5-6,9-12,23H,2-4,7-8H2,1H3,(H,21,26)
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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224902
PNG
(US9321756, 154)
Show SMILES CCN(CC)c1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C18H19N7S/c1-3-25(4-2)16-10-20-9-15(22-16)13-8-21-14-6-5-11(7-12(13)14)17-23-24-18(19)26-17/h5-10,21H,3-4H2,1-2H3,(H2,19,24)
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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224961
PNG
(US9321756, 228)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)-n3cnc(C)c3)c2c1
Show InChI InChI=1S/C20H17N7S/c1-12-10-27(11-23-12)18-5-3-4-17(24-18)15-9-22-16-7-6-13(8-14(15)16)19-25-26-20(21-2)28-19/h3-11,22H,1-2H3,(H,21,26)
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AMGEN INC.

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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM224842
PNG
(US9321756, 101)
Show SMILES CC(C)Nc1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)o1
Show InChI InChI=1S/C17H17N7O/c1-9(2)21-15-8-19-7-14(22-15)12-6-20-13-4-3-10(5-11(12)13)16-23-24-17(18)25-16/h3-9,20H,1-2H3,(H2,18,24)(H,21,22)
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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50061613
PNG
(CHEMBL3394164 | US9321756, 17)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C19H19N7S/c20-19-26-25-18(27-19)11-5-6-15-13(7-11)14(8-22-15)16-9-21-10-17(24-16)23-12-3-1-2-4-12/h5-10,12,22H,1-4H2,(H2,20,26)(H,23,24)
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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM225065
PNG
(US9321756, 34)
Show SMILES CC(C)Oc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(s1)N1CC[C@H](N)C1
Show InChI InChI=1S/C22H24N6OS/c1-13(2)29-20-5-3-4-19(25-20)17-11-24-18-7-6-14(10-16(17)18)21-26-27-22(30-21)28-9-8-15(23)12-28/h3-7,10-11,13,15,24H,8-9,12,23H2,1-2H3/t15-/m0/s1
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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM224873
PNG
(US9321756, 128)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3nccc(n3)N3CCC[C@H](N)C3)c2c1
Show InChI InChI=1S/C20H22N8S/c1-22-20-27-26-19(29-20)12-4-5-16-14(9-12)15(10-24-16)18-23-7-6-17(25-18)28-8-2-3-13(21)11-28/h4-7,9-10,13,24H,2-3,8,11,21H2,1H3,(H,22,27)/t13-/m0/s1
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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM225085
PNG
(US9321756, 54)
Show SMILES CC(C)(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1
Show InChI InChI=1S/C21H22N6O/c1-21(2,3)25-20-27-26-19(28-20)13-6-7-17-14(10-13)15(11-23-17)18-22-9-8-16(24-18)12-4-5-12/h6-12,23H,4-5H2,1-3H3,(H,25,27)
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AMGEN INC.

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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50061603
PNG
(CHEMBL3394167 | US9321756, 157)
Show SMILES CC(C)Oc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C18H17N5OS/c1-10(2)24-16-5-3-4-15(21-16)13-9-20-14-7-6-11(8-12(13)14)17-22-23-18(19)25-17/h3-10,20H,1-2H3,(H2,19,23)
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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224839
PNG
(US9321756, 98)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(n3)C3CC3)c2c1
Show InChI InChI=1S/C17H14N6O/c18-17-23-22-16(24-17)10-3-4-13-11(5-10)12(6-20-13)15-8-19-7-14(21-15)9-1-2-9/h3-9,20H,1-2H2,(H2,18,23)
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Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224829
PNG
(US9321756, 88)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(n3)N3CCC(F)(F)C3)c2c1
Show InChI InChI=1S/C18H15F2N7O/c19-18(20)3-4-27(9-18)15-8-22-7-14(24-15)12-6-23-13-2-1-10(5-11(12)13)16-25-26-17(21)28-16/h1-2,5-8,23H,3-4,9H2,(H2,21,26)
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224844
PNG
(BDBM225043 | US9321756, 103)
Show SMILES CC(C)Nc1ccnc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)o1
Show InChI InChI=1S/C17H17N7O/c1-9(2)21-14-5-6-19-15(22-14)12-8-20-13-4-3-10(7-11(12)13)16-23-24-17(18)25-16/h3-9,20H,1-2H3,(H2,18,24)(H,19,21,22)
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UniChem
US Patent
n/an/a 1.67n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224844
PNG
(BDBM225043 | US9321756, 103)
Show SMILES CC(C)Nc1ccnc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)o1
Show InChI InChI=1S/C17H17N7O/c1-9(2)21-14-5-6-19-15(22-14)12-8-20-13-4-3-10(7-11(12)13)16-23-24-17(18)25-16/h3-9,20H,1-2H3,(H2,18,24)(H,19,21,22)
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.67n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM224944
PNG
(US9321756, 207)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(NCC4CC4)n3)c2c1
Show InChI InChI=1S/C18H17N7S/c19-18-25-24-17(26-18)11-3-4-14-12(5-11)13(7-21-14)15-8-20-9-16(23-15)22-6-10-1-2-10/h3-5,7-10,21H,1-2,6H2,(H2,19,25)(H,22,23)
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UniProtKB/SwissProt

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AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.68n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%