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Patent code US9321790

Compile Data Set for Download or QSAR
Found 119 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226282
PNG
(US9321790, 94)
Show SMILES CC(=O)N1CCC(CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CC1
Show InChI InChI=1S/C21H28F3N5O3/c1-13(30)26-5-2-14(3-6-26)10-29-17(21(22,23)24)4-7-27-19(31)9-18(25-20(27)29)28-11-16-8-15(28)12-32-16/h9,14-17H,2-8,10-12H2,1H3/t15-,16-,17-/m0/s1
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Sanofi

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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226283
PNG
(US9321790, 95)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC1CCN(CC1)C=O
Show InChI InChI=1S/C20H26F3N5O3/c21-20(22,23)16-3-6-26-18(30)8-17(27-10-15-7-14(27)11-31-15)24-19(26)28(16)9-13-1-4-25(12-29)5-2-13/h8,12-16H,1-7,9-11H2/t14-,15-,16?/m0/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226271
PNG
(US9321790, 83)
Show SMILES Oc1ccc(CCN2[C@@H](CCn3c2nc(cc3=O)N2CC3CCC(C2)O3)C(F)(F)F)cc1
Show InChI InChI=1S/C22H25F3N4O3/c23-22(24,25)18-8-10-29-20(31)11-19(27-12-16-5-6-17(13-27)32-16)26-21(29)28(18)9-7-14-1-3-15(30)4-2-14/h1-4,11,16-18,30H,5-10,12-13H2/t16?,17?,18-/m0/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226272
PNG
(US9321790, 84)
Show SMILES Cc1c(nc2N(CCCc3ccccc3)[C@@H](CCn2c1=O)C(F)(F)F)N1CC2CCC(C1)O2
Show InChI InChI=1S/C24H29F3N4O2/c1-16-21(29-14-18-9-10-19(15-29)33-18)28-23-30(12-5-8-17-6-3-2-4-7-17)20(24(25,26)27)11-13-31(23)22(16)32/h2-4,6-7,18-20H,5,8-15H2,1H3/t18?,19?,20-/m0/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226266
PNG
(US9321790, 78)
Show SMILES CN(C)CCCOc1ccc(CCN2c3nc(cc(=O)n3C[C@@]2(C)C(F)(F)F)N2CC3CCC(C2)O3)cc1
Show InChI InChI=1S/C27H36F3N5O3/c1-26(27(28,29)30)18-34-24(36)15-23(33-16-21-9-10-22(17-33)38-21)31-25(34)35(26)13-11-19-5-7-20(8-6-19)37-14-4-12-32(2)3/h5-8,15,21-22H,4,9-14,16-18H2,1-3H3/t21?,22?,26-/m0/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226299
PNG
(US9321790, 111)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCc1ccc(OCCN2CCOCC2)cc1
Show InChI InChI=1S/C27H34F3N5O4/c28-27(29,30)23-6-8-34-25(36)16-24(35-17-22-15-20(35)18-39-22)31-26(34)33(23)7-5-19-1-3-21(4-2-19)38-14-11-32-9-12-37-13-10-32/h1-4,16,20,22-23H,5-15,17-18H2/t20-,22-,23-/m0/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226270
PNG
(US9321790, 82)
Show SMILES O[C@H](CN1[C@@H](CCn2c1nc(cc2=O)N1CC2CCC(C1)O2)C(F)(F)F)c1cc2ccccc2s1
Show InChI InChI=1S/C24H25F3N4O3S/c25-24(26,27)20-7-8-30-22(33)10-21(29-11-15-5-6-16(12-29)34-15)28-23(30)31(20)13-17(32)19-9-14-3-1-2-4-18(14)35-19/h1-4,9-10,15-17,20,32H,5-8,11-13H2/t15?,16?,17-,20+/m1/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226305
PNG
(US9321790, 117)
Show SMILES CN(C)CCOc1ccc(CCN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)cc1
Show InChI InChI=1S/C25H32F3N5O3/c1-30(2)11-12-35-19-5-3-17(4-6-19)7-9-31-21(25(26,27)28)8-10-32-23(34)14-22(29-24(31)32)33-15-20-13-18(33)16-36-20/h3-6,14,18,20-21H,7-13,15-16H2,1-2H3/t18-,20-,21-/m0/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226285
PNG
(US9321790, 97)
Show SMILES OC(CCN1C(CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H19F9N4O3/c19-16(20,21)11-1-3-30-13(32)6-12(31-7-10-5-9(31)8-34-10)28-14(30)29(11)4-2-15(33,17(22,23)24)18(25,26)27/h6,9-11,33H,1-5,7-8H2/t9-,10-,11?/m0/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226289
PNG
(US9321790, 101)
Show SMILES OC1(CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CCCC1
Show InChI InChI=1S/C19H25F3N4O3/c20-19(21,22)14-3-6-24-16(27)8-15(25-9-13-7-12(25)10-29-13)23-17(24)26(14)11-18(28)4-1-2-5-18/h8,12-14,28H,1-7,9-11H2/t12-,13-,14-/m0/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226280
PNG
(US9321790, 92)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCC1CCOCC1
Show InChI InChI=1S/C20H27F3N4O3/c21-20(22,23)16-2-6-26-18(28)10-17(27-11-15-9-14(27)12-30-15)24-19(26)25(16)5-1-13-3-7-29-8-4-13/h10,13-16H,1-9,11-12H2/t14-,15-,16?/m0/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226303
PNG
(US9321790, 115)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCc1ccc(OCC(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C27H32F3N5O5/c28-27(29,30)22-6-8-34-24(36)14-23(35-15-21-13-19(35)16-39-21)31-26(34)33(22)7-5-18-1-3-20(4-2-18)40-17-25(37)32-9-11-38-12-10-32/h1-4,14,19,21-22H,5-13,15-17H2/t19-,21-,22-/m0/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226260
PNG
(US9321790, 72)
Show SMILES C[C@]1(Cn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CCc1ccc(O)cc1)C(F)(F)F
Show InChI InChI=1S/C22H25F3N4O3/c1-21(22(23,24)25)13-28-19(31)10-18(27-11-16-6-7-17(12-27)32-16)26-20(28)29(21)9-8-14-2-4-15(30)5-3-14/h2-5,10,16-17,30H,6-9,11-13H2,1H3/t16?,17?,21-/m0/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226281
PNG
(US9321790, 93)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC1CCOCC1
Show InChI InChI=1S/C19H25F3N4O3/c20-19(21,22)15-1-4-24-17(27)8-16(25-10-14-7-13(25)11-29-14)23-18(24)26(15)9-12-2-5-28-6-3-12/h8,12-15H,1-7,9-11H2/t13-,14-,15?/m0/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226259
PNG
(US9321790, 71)
Show SMILES COc1cc(F)ccc1[C@H](O)CN1[C@@H](CCn2c1nc(cc2=O)N1CC2CCC(C1)O2)C(F)(F)F
Show InChI InChI=1S/C23H26F4N4O4/c1-34-18-8-13(24)2-5-16(18)17(32)12-31-19(23(25,26)27)6-7-30-21(33)9-20(28-22(30)31)29-10-14-3-4-15(11-29)35-14/h2,5,8-9,14-15,17,19,32H,3-4,6-7,10-12H2,1H3/t14?,15?,17-,19+/m1/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226265
PNG
(US9321790, 77)
Show SMILES C[C@]1(Cn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CCCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C23H27F3N4O2/c1-22(23(24,25)26)15-29-20(31)12-19(28-13-17-9-10-18(14-28)32-17)27-21(29)30(22)11-5-8-16-6-3-2-4-7-16/h2-4,6-7,12,17-18H,5,8-11,13-15H2,1H3/t17?,18?,22-/m0/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226262
PNG
(US9321790, 74)
Show SMILES CN(C)CCOc1ccc(CCN2c3nc(cc(=O)n3C[C@@]2(C)C(F)(F)F)N2CC3CCC(C2)O3)cc1
Show InChI InChI=1S/C26H34F3N5O3/c1-25(26(27,28)29)17-33-23(35)14-22(32-15-20-8-9-21(16-32)37-20)30-24(33)34(25)11-10-18-4-6-19(7-5-18)36-13-12-31(2)3/h4-7,14,20-21H,8-13,15-17H2,1-3H3/t20?,21?,25-/m0/s1
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US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226291
PNG
(US9321790, 103)
Show SMILES OC(CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F)(C1CC1)C1CC1
Show InChI InChI=1S/C21H27F3N4O3/c22-21(23,24)16-5-6-26-18(29)8-17(27-9-15-7-14(27)10-31-15)25-19(26)28(16)11-20(30,12-1-2-12)13-3-4-13/h8,12-16,30H,1-7,9-11H2/t14-,15-,16-/m0/s1
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Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226292
PNG
(US9321790, 104)
Show SMILES OC1(CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CC1
Show InChI InChI=1S/C17H21F3N4O3/c18-17(19,20)12-1-4-22-14(25)6-13(23-7-11-5-10(23)8-27-11)21-15(22)24(12)9-16(26)2-3-16/h6,10-12,26H,1-5,7-9H2/t10-,11-,12-/m0/s1
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US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226264
PNG
(US9321790, 76)
Show SMILES COc1ccc(CCN2c3nc(cc(=O)n3C[C@@]2(C)C(F)(F)F)N2CC3CCC(C2)O3)cc1
Show InChI InChI=1S/C23H27F3N4O3/c1-22(23(24,25)26)14-29-20(31)11-19(28-12-17-7-8-18(13-28)33-17)27-21(29)30(22)10-9-15-3-5-16(32-2)6-4-15/h3-6,11,17-18H,7-10,12-14H2,1-2H3/t17?,18?,22-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226213
PNG
(US9321790, 25)
Show SMILES Cc1ncsc1CCN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C19H22F3N5O2S/c1-11-14(30-10-23-11)2-4-25-15(19(20,21)22)3-5-26-17(28)7-16(24-18(25)26)27-8-13-6-12(27)9-29-13/h7,10,12-13,15H,2-6,8-9H2,1H3/t12-,13-,15-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226258
PNG
(US9321790, 70)
Show SMILES CN(C)C(=O)COc1ccc(CCN2c3nc(cc(=O)n3C[C@@]2(C)C(F)(F)F)N2CC3CCC(C2)O3)cc1
Show InChI InChI=1S/C26H32F3N5O4/c1-25(26(27,28)29)16-33-22(35)12-21(32-13-19-8-9-20(14-32)38-19)30-24(33)34(25)11-10-17-4-6-18(7-5-17)37-15-23(36)31(2)3/h4-7,12,19-20H,8-11,13-16H2,1-3H3/t19?,20?,25-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226211
PNG
(US9321790, 23)
Show SMILES CCNC(=O)Nc1ccc(CCN2C(CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)cc1
Show InChI InChI=1S/C24H29F3N6O3/c1-2-28-22(35)29-16-5-3-15(4-6-16)7-9-31-19(24(25,26)27)8-10-32-21(34)12-20(30-23(31)32)33-13-18-11-17(33)14-36-18/h3-6,12,17-19H,2,7-11,13-14H2,1H3,(H2,28,29,35)/t17-,18-,19?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226276
PNG
(US9321790, 88)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CC(=O)c1ccccn1
Show InChI InChI=1S/C21H22F3N5O3/c22-21(23,24)17-6-8-28-19(31)9-18(27-10-13-4-5-14(11-27)32-13)26-20(28)29(17)12-16(30)15-3-1-2-7-25-15/h1-3,7,9,13-14,17H,4-6,8,10-12H2/t13?,14?,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226215
PNG
(US9321790, 27)
Show SMILES Cc1n[nH]c(C)c1CCN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C20H25F3N6O2/c1-11-15(12(2)26-25-11)3-5-27-16(20(21,22)23)4-6-28-18(30)8-17(24-19(27)28)29-9-14-7-13(29)10-31-14/h8,13-14,16H,3-7,9-10H2,1-2H3,(H,25,26)/t13-,14-,16-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226268
PNG
(US9321790, 80)
Show SMILES O[C@H](CN1[C@@H](CCn2c1nc(cc2=O)N1CC2CCC(C1)O2)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C22H25F3N4O3/c23-22(24,25)18-8-9-28-20(31)10-19(27-11-15-6-7-16(12-27)32-15)26-21(28)29(18)13-17(30)14-4-2-1-3-5-14/h1-5,10,15-18,30H,6-9,11-13H2/t15?,16?,17-,18+/m1/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226267
PNG
(US9321790, 79)
Show SMILES C[C@]1(Cn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1C[C@@H](O)c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C22H25F3N4O3/c1-21(22(23,24)25)13-28-19(31)9-18(27-10-15-7-8-16(11-27)32-15)26-20(28)29(21)12-17(30)14-5-3-2-4-6-14/h2-6,9,15-17,30H,7-8,10-13H2,1H3/t15?,16?,17-,21+/m1/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226293
PNG
(US9321790, 105)
Show SMILES OC1(CCN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CC1
Show InChI InChI=1S/C18H23F3N4O3/c19-18(20,21)13-1-5-24-15(26)8-14(25-9-12-7-11(25)10-28-12)22-16(24)23(13)6-4-17(27)2-3-17/h8,11-13,27H,1-7,9-10H2/t11-,12-,13-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226288
PNG
(US9321790, 100)
Show SMILES OC1(CCN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CCCC1
Show InChI InChI=1S/C20H27F3N4O3/c21-20(22,23)15-3-7-26-17(28)10-16(27-11-14-9-13(27)12-30-14)24-18(26)25(15)8-6-19(29)4-1-2-5-19/h10,13-15,29H,1-9,11-12H2/t13-,14-,15-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226269
PNG
(US9321790, 81)
Show SMILES COc1ccc(CCN2[C@@H](CCn3c2nc(cc3=O)N2CC3CCC(C2)O3)C(F)(F)F)cc1
Show InChI InChI=1S/C23H27F3N4O3/c1-32-16-4-2-15(3-5-16)8-10-29-19(23(24,25)26)9-11-30-21(31)12-20(27-22(29)30)28-13-17-6-7-18(14-28)33-17/h2-5,12,17-19H,6-11,13-14H2,1H3/t17?,18?,19-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226214
PNG
(US9321790, 26)
Show SMILES Cc1ncsc1CCN1c2nc(cc(=O)n2CC1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2
Show InChI InChI=1S/C19H22F3N5O2S/c1-11-14(30-10-23-11)3-4-27-17-24-15(25-7-13-5-12(25)8-29-13)6-16(28)26(17)9-18(27,2)19(20,21)22/h6,10,12-13H,3-5,7-9H2,1-2H3/t12-,13-,18?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226242
PNG
(US9321790, 54)
Show SMILES CCC(O)(CC)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C19H27F3N4O3/c1-3-18(28,4-2)11-26-14(19(20,21)22)5-6-24-16(27)8-15(23-17(24)26)25-9-13-7-12(25)10-29-13/h8,12-14,28H,3-7,9-11H2,1-2H3/t12-,13-,14-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226216
PNG
(US9321790, 28)
Show SMILES Cc1n[nH]c(C)c1CCN1c2nc(cc(=O)n2CC1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2
Show InChI InChI=1S/C20H25F3N6O2/c1-11-15(12(2)26-25-11)4-5-29-18-24-16(27-8-14-6-13(27)9-31-14)7-17(30)28(18)10-19(29,3)20(21,22)23/h7,13-14H,4-6,8-10H2,1-3H3,(H,25,26)/t13-,14-,19?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226278
PNG
(US9321790, 90)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCC1CCN(CC1)C=O
Show InChI InChI=1S/C21H28F3N5O3/c22-21(23,24)17-4-8-28-19(31)10-18(29-11-16-9-15(29)12-32-16)25-20(28)27(17)7-3-14-1-5-26(13-30)6-2-14/h10,13-17H,1-9,11-12H2/t15-,16-,17?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226212
PNG
(US9321790, 24)
Show SMILES CCNC(=O)Nc1ccc(CCN2c3nc(cc(=O)n3C[C@@]2(C)C(F)(F)F)N2C[C@@H]3C[C@H]2CO3)cc1
Show InChI InChI=1S/C24H29F3N6O3/c1-3-28-21(35)29-16-6-4-15(5-7-16)8-9-33-22-30-19(31-12-18-10-17(31)13-36-18)11-20(34)32(22)14-23(33,2)24(25,26)27/h4-7,11,17-18H,3,8-10,12-14H2,1-2H3,(H2,28,29,35)/t17-,18-,23-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226290
PNG
(US9321790, 102)
Show SMILES OC(CCN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F)(C1CC1)C1CC1
Show InChI InChI=1S/C22H29F3N4O3/c23-22(24,25)17-5-7-28-19(30)10-18(29-11-16-9-15(29)12-32-16)26-20(28)27(17)8-6-21(31,13-1-2-13)14-3-4-14/h10,13-17,31H,1-9,11-12H2/t15-,16-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226261
PNG
(US9321790, 73)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CC(=O)c1ccccc1
Show InChI InChI=1S/C22H23F3N4O3/c23-22(24,25)18-8-9-28-20(31)10-19(27-11-15-6-7-16(12-27)32-15)26-21(28)29(18)13-17(30)14-4-2-1-3-5-14/h1-5,10,15-16,18H,6-9,11-13H2/t15?,16?,18-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226237
PNG
(US9321790, 49)
Show SMILES CCC(O)(CC)CCN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C20H29F3N4O3/c1-3-19(29,4-2)6-8-25-15(20(21,22)23)5-7-26-17(28)10-16(24-18(25)26)27-11-14-9-13(27)12-30-14/h10,13-15,29H,3-9,11-12H2,1-2H3/t13-,14-,15-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226277
PNG
(US9321790, 89)
Show SMILES CC(=O)N1CCC(CCN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CC1
Show InChI InChI=1S/C22H30F3N5O3/c1-14(31)27-6-2-15(3-7-27)4-8-28-18(22(23,24)25)5-9-29-20(32)11-19(26-21(28)29)30-12-17-10-16(30)13-33-17/h11,15-18H,2-10,12-13H2,1H3/t16-,17-,18-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226200
PNG
(US9321790, 12)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCc1cccnc1
Show InChI InChI=1S/C20H22F3N5O2/c21-20(22,23)16-4-7-27-18(29)9-17(28-11-15-8-14(28)12-30-15)25-19(27)26(16)6-3-13-2-1-5-24-10-13/h1-2,5,9-10,14-16H,3-4,6-8,11-12H2/t14-,15-,16?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226189
PNG
(US9321790, 1)
Show SMILES CC(C)(CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C22H26F3N5O2/c1-21(2,14-3-6-26-7-4-14)13-30-17(22(23,24)25)5-8-28-19(31)10-18(27-20(28)30)29-11-16-9-15(29)12-32-16/h3-4,6-7,10,15-17H,5,8-9,11-13H2,1-2H3/t15-,16-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226220
PNG
(US9321790, 32)
Show SMILES CC1(Cn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCc1ccc(N)cc1)C(F)(F)F
Show InChI InChI=1S/C21H24F3N5O2/c1-20(21(22,23)24)12-28-18(30)9-17(27-10-16-8-15(27)11-31-16)26-19(28)29(20)7-6-13-2-4-14(25)5-3-13/h2-5,9,15-16H,6-8,10-12,25H2,1H3/t15-,16-,20?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226255
PNG
(US9321790, 67)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)C1CC1
Show InChI InChI=1S/C18H21F3N4O3/c19-18(20,21)14-3-4-23-16(27)6-15(24-7-12-5-11(24)9-28-12)22-17(23)25(14)8-13(26)10-1-2-10/h6,10-12,14H,1-5,7-9H2/t11-,12-,14-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226229
PNG
(US9321790, 41)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C25H28F3N5O4/c26-25(27,28)21-5-6-31-23(35)12-22(32-13-19-11-18(32)15-37-19)29-24(31)33(21)14-20(34)16-1-3-17(4-2-16)30-7-9-36-10-8-30/h1-4,12,18-19,21H,5-11,13-15H2/t18-,19-,21-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226238
PNG
(US9321790, 50)
Show SMILES CC(C)(O)CCN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C18H25F3N4O3/c1-17(2,27)4-6-23-13(18(19,20)21)3-5-24-15(26)8-14(22-16(23)24)25-9-12-7-11(25)10-28-12/h8,11-13,27H,3-7,9-10H2,1-2H3/t11-,12-,13-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226201
PNG
(US9321790, 13)
Show SMILES CC1(Cn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCc1cccnc1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N5O2/c1-19(20(21,22)23)12-27-17(29)8-16(26-10-15-7-14(26)11-30-15)25-18(27)28(19)6-4-13-3-2-5-24-9-13/h2-3,5,8-9,14-15H,4,6-7,10-12H2,1H3/t14-,15-,19?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226226
PNG
(US9321790, 38)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1cnc2NCCOc2c1
Show InChI InChI=1S/C22H23F3N6O4/c23-22(24,25)17-1-3-29-19(33)7-18(30-9-14-6-13(30)11-35-14)28-21(29)31(17)10-15(32)12-5-16-20(27-8-12)26-2-4-34-16/h5,7-8,13-14,17H,1-4,6,9-11H2,(H,26,27)/t13-,14-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226219
PNG
(US9321790, 31)
Show SMILES Cc1cc(cnc1N)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C21H23F3N6O3/c1-11-4-12(7-26-19(11)25)15(31)9-30-16(21(22,23)24)2-3-28-18(32)6-17(27-20(28)30)29-8-14-5-13(29)10-33-14/h4,6-7,13-14,16H,2-3,5,8-10H2,1H3,(H2,25,26)/t13-,14-,16-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226246
PNG
(US9321790, 58)
Show SMILES COC(=O)Nc1ccc(cn1)C(=O)CN1C(CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C22H23F3N6O5/c1-35-21(34)27-17-3-2-12(8-26-17)15(32)10-31-16(22(23,24)25)4-5-29-19(33)7-18(28-20(29)31)30-9-14-6-13(30)11-36-14/h2-3,7-8,13-14,16H,4-6,9-11H2,1H3,(H,26,27,34)/t13-,14-,16?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226256
PNG
(US9321790, 68)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccccn1
Show InChI InChI=1S/C20H20F3N5O3/c21-20(22,23)16-4-6-26-18(30)8-17(27-9-13-7-12(27)11-31-13)25-19(26)28(16)10-15(29)14-3-1-2-5-24-14/h1-3,5,8,12-13,16H,4,6-7,9-11H2/t12-,13-,16?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226191
PNG
(US9321790, 3)
Show SMILES Nc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C20H21F3N6O3/c21-20(22,23)15-3-4-27-18(31)6-17(28-8-13-5-12(28)10-32-13)26-19(27)29(15)9-14(30)11-1-2-16(24)25-7-11/h1-2,6-7,12-13,15H,3-5,8-10H2,(H2,24,25)/t12-,13-,15-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226204
PNG
(US9321790, 16)
Show SMILES Cc1cncc(c1)C(=O)CN1c2nc(cc(=O)n2CC1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2
Show InChI InChI=1S/C21H22F3N5O3/c1-12-3-13(7-25-6-12)16(30)9-29-19-26-17(27-8-15-4-14(27)10-32-15)5-18(31)28(19)11-20(29,2)21(22,23)24/h3,5-7,14-15H,4,8-11H2,1-2H3/t14-,15-,20?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226251
PNG
(US9321790, 63)
Show SMILES FCCOc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C22H23F4N5O4/c23-4-6-34-19-2-1-13(9-27-19)16(32)11-31-17(22(24,25)26)3-5-29-20(33)8-18(28-21(29)31)30-10-15-7-14(30)12-35-15/h1-2,8-9,14-15,17H,3-7,10-12H2/t14-,15-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226203
PNG
(US9321790, 15)
Show SMILES Cc1cncc(c1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O3/c1-12-4-13(8-25-7-12)16(30)10-29-17(21(22,23)24)2-3-27-19(31)6-18(26-20(27)29)28-9-15-5-14(28)11-32-15/h4,6-8,14-15,17H,2-3,5,9-11H2,1H3/t14-,15-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226198
PNG
(US9321790, 10)
Show SMILES COc1ccc(CCN2c3nc(cc(=O)n3CC2(C)C(F)(F)F)N2C[C@@H]3C[C@H]2CO3)cc1
Show InChI InChI=1S/C22H25F3N4O3/c1-21(22(23,24)25)13-28-19(30)10-18(27-11-17-9-15(27)12-32-17)26-20(28)29(21)8-7-14-3-5-16(31-2)6-4-14/h3-6,10,15,17H,7-9,11-13H2,1-2H3/t15-,17-,21?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226274
PNG
(US9321790, 86)
Show SMILES FC(F)n1ccc(CN2[C@@H](CCn3c2nc(cc3=O)N2CC3CCC(C2)O3)C(F)(F)F)n1
Show InChI InChI=1S/C19H21F5N6O2/c20-17(21)30-6-3-11(26-30)8-29-14(19(22,23)24)4-5-28-16(31)7-15(25-18(28)29)27-9-12-1-2-13(10-27)32-12/h3,6-7,12-14,17H,1-2,4-5,8-10H2/t12?,13?,14-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226297
PNG
(US9321790, 109)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1Cc1cccc2cnccc12
Show InChI InChI=1S/C23H22F3N5O2/c24-23(25,26)19-5-7-29-21(32)9-20(30-12-17-8-16(30)13-33-17)28-22(29)31(19)11-15-3-1-2-14-10-27-6-4-18(14)15/h1-4,6,9-10,16-17,19H,5,7-8,11-13H2/t16-,17-,19-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226217
PNG
(US9321790, 29)
Show SMILES CC(C)(C)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C19H25F3N4O3/c1-18(2,3)14(27)9-26-13(19(20,21)22)4-5-24-16(28)7-15(23-17(24)26)25-8-12-6-11(25)10-29-12/h7,11-13H,4-6,8-10H2,1-3H3/t11-,12-,13-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226193
PNG
(US9321790, 5)
Show SMILES CNc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C21H23F3N6O3/c1-25-17-3-2-12(8-26-17)15(31)10-30-16(21(22,23)24)4-5-28-19(32)7-18(27-20(28)30)29-9-14-6-13(29)11-33-14/h2-3,7-8,13-14,16H,4-6,9-11H2,1H3,(H,25,26)/t13-,14-,16-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226284
PNG
(US9321790, 96)
Show SMILES OC(CN1C(CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H17F9N4O3/c18-15(19,20)10-1-2-28-12(31)4-11(29-5-9-3-8(29)6-33-9)27-13(28)30(10)7-14(32,16(21,22)23)17(24,25)26/h4,8-10,32H,1-3,5-7H2/t8-,9-,10?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226275
PNG
(US9321790, 87)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CC(=O)c1cccnc1
Show InChI InChI=1S/C21H22F3N5O3/c22-21(23,24)17-5-7-28-19(31)8-18(27-10-14-3-4-15(11-27)32-14)26-20(28)29(17)12-16(30)13-2-1-6-25-9-13/h1-2,6,8-9,14-15,17H,3-5,7,10-12H2/t14?,15?,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226287
PNG
(US9321790, 99)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2CC3C[C@H]2CO3)N1CC(=O)N1C2CC[C@H]1COC2
Show InChI InChI=1S/C21H26F3N5O4/c22-21(23,24)16-3-4-26-18(30)6-17(27-7-15-5-14(27)11-33-15)25-20(26)28(16)8-19(31)29-12-1-2-13(29)10-32-9-12/h6,12-16H,1-5,7-11H2/t12-,13?,14-,15?,16?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226295
PNG
(US9321790, 107)
Show SMILES Cc1nscc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C19H20F3N5O3S/c1-10-13(9-31-24-10)14(28)7-27-15(19(20,21)22)2-3-25-17(29)5-16(23-18(25)27)26-6-12-4-11(26)8-30-12/h5,9,11-12,15H,2-4,6-8H2,1H3/t11-,12-,15-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226190
PNG
(US9321790, 2)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccncc1
Show InChI InChI=1S/C20H20F3N5O3/c21-20(22,23)16-3-6-26-18(30)8-17(27-9-14-7-13(27)11-31-14)25-19(26)28(16)10-15(29)12-1-4-24-5-2-12/h1-2,4-5,8,13-14,16H,3,6-7,9-11H2/t13-,14-,16?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226209
PNG
(US9321790, 21)
Show SMILES CC1(Cn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1cccnc1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N5O3/c1-19(20(21,22)23)11-27-17(30)6-16(26-8-14-5-13(26)10-31-14)25-18(27)28(19)9-15(29)12-3-2-4-24-7-12/h2-4,6-7,13-14H,5,8-11H2,1H3/t13-,14-,19?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226234
PNG
(US9321790, 46)
Show SMILES Cc1nocc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C19H20F3N5O4/c1-10-13(9-31-24-10)14(28)7-27-15(19(20,21)22)2-3-25-17(29)5-16(23-18(25)27)26-6-12-4-11(26)8-30-12/h5,9,11-12,15H,2-4,6-8H2,1H3/t11-,12-,15-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226252
PNG
(US9321790, 64)
Show SMILES FCCOc1ccc(cc1F)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C23H23F5N4O4/c24-4-6-35-18-2-1-13(7-16(18)25)17(33)11-32-19(23(26,27)28)3-5-30-21(34)9-20(29-22(30)32)31-10-15-8-14(31)12-36-15/h1-2,7,9,14-15,19H,3-6,8,10-12H2/t14-,15-,19-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226263
PNG
(US9321790, 75)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CC(=O)c1ccncc1
Show InChI InChI=1S/C21H22F3N5O3/c22-21(23,24)17-5-8-28-19(31)9-18(27-10-14-1-2-15(11-27)32-14)26-20(28)29(17)12-16(30)13-3-6-25-7-4-13/h3-4,6-7,9,14-15,17H,1-2,5,8,10-12H2/t14?,15?,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226286
PNG
(US9321790, 98)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2CC3C[C@H]2CO3)N1CC(=O)N1CC2CC[C@@H](C1)O2
Show InChI InChI=1S/C21H26F3N5O4/c22-21(23,24)16-3-4-27-18(30)6-17(28-9-15-5-12(28)11-32-15)25-20(27)29(16)10-19(31)26-7-13-1-2-14(8-26)33-13/h6,12-16H,1-5,7-11H2/t12-,13-,14?,15?,16?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226197
PNG
(US9321790, 9)
Show SMILES CNc1ccc(cn1)C(=O)CN1c2nc(cc(=O)n2C[C@@]1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2
Show InChI InChI=1S/C21H23F3N6O3/c1-20(21(22,23)24)11-29-18(32)6-17(28-8-14-5-13(28)10-33-14)27-19(29)30(20)9-15(31)12-3-4-16(25-2)26-7-12/h3-4,6-7,13-14H,5,8-11H2,1-2H3,(H,25,26)/t13-,14-,20-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226202
PNG
(US9321790, 14)
Show SMILES OCCNc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C22H25F3N6O4/c23-22(24,25)17-3-5-29-20(34)8-19(30-10-15-7-14(30)12-35-15)28-21(29)31(17)11-16(33)13-1-2-18(27-9-13)26-4-6-32/h1-2,8-9,14-15,17,32H,3-7,10-12H2,(H,26,27)/t14-,15-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226223
PNG
(US9321790, 35)
Show SMILES CCOc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C22H24F3N5O4/c1-2-33-19-4-3-13(9-26-19)16(31)11-30-17(22(23,24)25)5-6-28-20(32)8-18(27-21(28)30)29-10-15-7-14(29)12-34-15/h3-4,8-9,14-15,17H,2,5-7,10-12H2,1H3/t14-,15-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226227
PNG
(US9321790, 39)
Show SMILES Cc1ncoc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C19H20F3N5O4/c1-10-17(31-9-23-10)13(28)7-27-14(19(20,21)22)2-3-25-16(29)5-15(24-18(25)27)26-6-12-4-11(26)8-30-12/h5,9,11-12,14H,2-4,6-8H2,1H3/t11-,12-,14-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226230
PNG
(US9321790, 42)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C22H20F3N5O3/c23-22(24,25)18-5-6-28-20(32)8-19(29-10-16-7-15(29)12-33-16)27-21(28)30(18)11-17(31)14-3-1-13(9-26)2-4-14/h1-4,8,15-16,18H,5-7,10-12H2/t15-,16-,18?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226231
PNG
(US9321790, 43)
Show SMILES Cc1ncsc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C19H20F3N5O3S/c1-10-17(31-9-23-10)13(28)7-27-14(19(20,21)22)2-3-25-16(29)5-15(24-18(25)27)26-6-12-4-11(26)8-30-12/h5,9,11-12,14H,2-4,6-8H2,1H3/t11-,12-,14-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226248
PNG
(US9321790, 60)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1cccnc1C(F)(F)F
Show InChI InChI=1S/C21H19F6N5O3/c22-20(23,24)15-3-5-30-17(34)7-16(31-8-12-6-11(31)10-35-12)29-19(30)32(15)9-14(33)13-2-1-4-28-18(13)21(25,26)27/h1-2,4,7,11-12,15H,3,5-6,8-10H2/t11-,12-,15?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226279
PNG
(US9321790, 91)
Show SMILES CCOC(=O)N1CCC(CC1)C(=O)CN1C(CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C23H30F3N5O5/c1-2-35-22(34)28-6-3-14(4-7-28)17(32)12-31-18(23(24,25)26)5-8-29-20(33)10-19(27-21(29)31)30-11-16-9-15(30)13-36-16/h10,14-16,18H,2-9,11-13H2,1H3/t15-,16-,18?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226194
PNG
(US9321790, 6)
Show SMILES CN(C)c1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C22H25F3N6O3/c1-28(2)18-4-3-13(9-26-18)16(32)11-31-17(22(23,24)25)5-6-29-20(33)8-19(27-21(29)31)30-10-15-7-14(30)12-34-15/h3-4,8-9,14-15,17H,5-7,10-12H2,1-2H3/t14-,15-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226195
PNG
(US9321790, 7)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1cccnc1
Show InChI InChI=1S/C20H20F3N5O3/c21-20(22,23)16-3-5-26-18(30)7-17(27-9-14-6-13(27)11-31-14)25-19(26)28(16)10-15(29)12-2-1-4-24-8-12/h1-2,4,7-8,13-14,16H,3,5-6,9-11H2/t13-,14-,16?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226208
PNG
(US9321790, 20)
Show SMILES Cc1ccncc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O3/c1-12-2-4-25-8-15(12)16(30)10-29-17(21(22,23)24)3-5-27-19(31)7-18(26-20(27)29)28-9-14-6-13(28)11-32-14/h2,4,7-8,13-14,17H,3,5-6,9-11H2,1H3/t13-,14-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226210
PNG
(US9321790, 22)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc(NC2CC2)nc1
Show InChI InChI=1S/C23H25F3N6O3/c24-23(25,26)18-5-6-30-21(34)8-20(31-10-16-7-15(31)12-35-16)29-22(30)32(18)11-17(33)13-1-4-19(27-9-13)28-14-2-3-14/h1,4,8-9,14-16,18H,2-3,5-7,10-12H2,(H,27,28)/t15-,16-,18-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226247
PNG
(US9321790, 59)
Show SMILES Cc1nc(CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)no1
Show InChI InChI=1S/C17H19F3N6O3/c1-9-21-13(23-29-9)7-26-12(17(18,19)20)2-3-24-15(27)5-14(22-16(24)26)25-6-11-4-10(25)8-28-11/h5,10-12H,2-4,6-8H2,1H3/t10-,11-,12-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226253
PNG
(US9321790, 65)
Show SMILES COc1ncccc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O4/c1-32-19-14(3-2-5-25-19)15(30)10-29-16(21(22,23)24)4-6-27-18(31)8-17(26-20(27)29)28-9-13-7-12(28)11-33-13/h2-3,5,8,12-13,16H,4,6-7,9-11H2,1H3/t12-,13-,16-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226294
PNG
(US9321790, 106)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1Cc1cccc2ncccc12
Show InChI InChI=1S/C23H22F3N5O2/c24-23(25,26)19-6-8-29-21(32)10-20(30-12-16-9-15(30)13-33-16)28-22(29)31(19)11-14-3-1-5-18-17(14)4-2-7-27-18/h1-5,7,10,15-16,19H,6,8-9,11-13H2/t15-,16-,19?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226300
PNG
(US9321790, 112)
Show SMILES CON(C)C(=O)CN1C(CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C17H22F3N5O4/c1-22(28-2)15(27)8-25-12(17(18,19)20)3-4-23-14(26)6-13(21-16(23)25)24-7-11-5-10(24)9-29-11/h6,10-12H,3-5,7-9H2,1-2H3/t10-,11-,12?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226302
PNG
(US9321790, 114)
Show SMILES FC(F)Oc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C21H20F5N5O4/c22-19(23)35-17-2-1-11(7-27-17)14(32)9-31-15(21(24,25)26)3-4-29-18(33)6-16(28-20(29)31)30-8-13-5-12(30)10-34-13/h1-2,6-7,12-13,15,19H,3-5,8-10H2/t12-,13-,15-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226304
PNG
(US9321790, 116)
Show SMILES Cn1cc(CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)c(n1)C(F)(F)F
Show InChI InChI=1S/C19H20F6N6O2/c1-28-6-10(16(27-28)19(23,24)25)7-31-13(18(20,21)22)2-3-29-15(32)5-14(26-17(29)31)30-8-12-4-11(30)9-33-12/h5-6,11-13H,2-4,7-9H2,1H3/t11-,12-,13-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226307
PNG
(US9321790, 119)
Show SMILES CC(=O)N1CCC(CC1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C22H28F3N5O4/c1-13(31)27-5-2-14(3-6-27)17(32)11-30-18(22(23,24)25)4-7-28-20(33)9-19(26-21(28)30)29-10-16-8-15(29)12-34-16/h9,14-16,18H,2-8,10-12H2,1H3/t15-,16-,18-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226196
PNG
(US9321790, 8)
Show SMILES CN(C)c1ccc(cn1)C(=O)CN1c2nc(cc(=O)n2C[C@@]1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2
Show InChI InChI=1S/C22H25F3N6O3/c1-21(22(23,24)25)12-30-19(33)7-18(29-9-15-6-14(29)11-34-15)27-20(30)31(21)10-16(32)13-4-5-17(26-8-13)28(2)3/h4-5,7-8,14-15H,6,9-12H2,1-3H3/t14-,15-,21-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226205
PNG
(US9321790, 17)
Show SMILES Cc1ccc(cn1)C(=O)CN1c2nc(cc(=O)n2CC1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2
Show InChI InChI=1S/C21H22F3N5O3/c1-12-3-4-13(7-25-12)16(30)9-29-19-26-17(27-8-15-5-14(27)10-32-15)6-18(31)28(19)11-20(29,2)21(22,23)24/h3-4,6-7,14-15H,5,8-11H2,1-2H3/t14-,15-,20?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226218
PNG
(US9321790, 30)
Show SMILES CC(C)(C)C(=O)CN1c2nc(cc(=O)n2CC1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2
Show InChI InChI=1S/C19H25F3N4O3/c1-17(2,3)13(27)8-26-16-23-14(24-7-12-5-11(24)9-29-12)6-15(28)25(16)10-18(26,4)19(20,21)22/h6,11-12H,5,7-10H2,1-4H3/t11-,12-,18?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226222
PNG
(US9321790, 34)
Show SMILES CN(CCO)c1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C23H27F3N6O4/c1-29(6-7-33)19-3-2-14(10-27-19)17(34)12-32-18(23(24,25)26)4-5-30-21(35)9-20(28-22(30)32)31-11-16-8-15(31)13-36-16/h2-3,9-10,15-16,18,33H,4-8,11-13H2,1H3/t15-,16-,18-/m0/s1
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US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226235
PNG
(US9321790, 47)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc2snnc2c1
Show InChI InChI=1S/C21H19F3N6O3S/c22-21(23,24)17-3-4-28-19(32)7-18(29-8-13-6-12(29)10-33-13)25-20(28)30(17)9-15(31)11-1-2-16-14(5-11)26-27-34-16/h1-2,5,7,12-13,17H,3-4,6,8-10H2/t12-,13-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226239
PNG
(US9321790, 51)
Show SMILES Cn1nc(CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)c2ccccc12
Show InChI InChI=1S/C22H23F3N6O2/c1-28-17-5-3-2-4-15(17)16(27-28)11-31-18(22(23,24)25)6-7-29-20(32)9-19(26-21(29)31)30-10-14-8-13(30)12-33-14/h2-5,9,13-14,18H,6-8,10-12H2,1H3/t13-,14-,18-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226243
PNG
(US9321790, 55)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1cccc(c1)C#N
Show InChI InChI=1S/C22H20F3N5O3/c23-22(24,25)18-4-5-28-20(32)8-19(29-10-16-7-15(29)12-33-16)27-21(28)30(18)11-17(31)14-3-1-2-13(6-14)9-26/h1-3,6,8,15-16,18H,4-5,7,10-12H2/t15-,16-,18?/m0/s1
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US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226244
PNG
(US9321790, 56)
Show SMILES CC(C)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C18H23F3N4O3/c1-10(2)13(26)8-25-14(18(19,20)21)3-4-23-16(27)6-15(22-17(23)25)24-7-12-5-11(24)9-28-12/h6,10-12,14H,3-5,7-9H2,1-2H3/t11-,12-,14-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226250
PNG
(US9321790, 62)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)C1CCOCC1
Show InChI InChI=1S/C20H25F3N4O4/c21-20(22,23)16-1-4-25-18(29)8-17(26-9-14-7-13(26)11-31-14)24-19(25)27(16)10-15(28)12-2-5-30-6-3-12/h8,12-14,16H,1-7,9-11H2/t13-,14-,16?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226273
PNG
(US9321790, 85)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C3CCC2COC3)N1CC(=O)c1cccnc1
Show InChI InChI=1S/C21H22F3N5O3/c22-21(23,24)17-5-7-27-19(31)8-18(29-14-3-4-15(29)12-32-11-14)26-20(27)28(17)10-16(30)13-2-1-6-25-9-13/h1-2,6,8-9,14-15,17H,3-5,7,10-12H2/t14?,15?,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226296
PNG
(US9321790, 108)
Show SMILES CS(=O)(=O)c1ccc(cc1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O5S/c1-35(32,33)16-4-2-13(3-5-16)17(30)11-29-18(22(23,24)25)6-7-27-20(31)9-19(26-21(27)29)28-10-15-8-14(28)12-34-15/h2-5,9,14-15,18H,6-8,10-12H2,1H3/t14-,15-,18-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226301
PNG
(US9321790, 113)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc2nccn2c1
Show InChI InChI=1S/C22H21F3N6O3/c23-22(24,25)17-3-5-29-20(33)8-19(30-10-15-7-14(30)12-34-15)27-21(29)31(17)11-16(32)13-1-2-18-26-4-6-28(18)9-13/h1-2,4,6,8-9,14-15,17H,3,5,7,10-12H2/t14-,15-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226306
PNG
(US9321790, 118)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)C1CCN(CC1)C=O
Show InChI InChI=1S/C21H26F3N5O4/c22-21(23,24)17-3-6-27-19(32)8-18(28-9-15-7-14(28)11-33-15)25-20(27)29(17)10-16(31)13-1-4-26(12-30)5-2-13/h8,12-15,17H,1-7,9-11H2/t14-,15-,17?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226225
PNG
(US9321790, 37)
Show SMILES FC(F)Oc1ccc(cc1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C22H21F5N4O4/c23-20(24)35-14-3-1-12(2-4-14)16(32)10-31-17(22(25,26)27)5-6-29-19(33)8-18(28-21(29)31)30-9-15-7-13(30)11-34-15/h1-4,8,13,15,17,20H,5-7,9-11H2/t13-,15-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226232
PNG
(US9321790, 44)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1cncc(Cl)c1
Show InChI InChI=1S/C20H19ClF3N5O3/c21-12-3-11(6-25-7-12)15(30)9-29-16(20(22,23)24)1-2-27-18(31)5-17(26-19(27)29)28-8-14-4-13(28)10-32-14/h3,5-7,13-14,16H,1-2,4,8-10H2/t13-,14-,16-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226233
PNG
(US9321790, 45)
Show SMILES COc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O4/c1-32-18-3-2-12(8-25-18)15(30)10-29-16(21(22,23)24)4-5-27-19(31)7-17(26-20(27)29)28-9-14-6-13(28)11-33-14/h2-3,7-8,13-14,16H,4-6,9-11H2,1H3/t13-,14-,16-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226240
PNG
(US9321790, 52)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1cnc(OCC2CC2)nc1
Show InChI InChI=1S/C23H25F3N6O4/c24-23(25,26)18-3-4-30-20(34)6-19(31-9-16-5-15(31)12-35-16)29-22(30)32(18)10-17(33)14-7-27-21(28-8-14)36-11-13-1-2-13/h6-8,13,15-16,18H,1-5,9-12H2/t15-,16-,18-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226224
PNG
(US9321790, 36)
Show SMILES Cc1c(N)ncc(C(=O)CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)c1C
Show InChI InChI=1S/C22H25F3N6O3/c1-11-12(2)20(26)27-7-15(11)16(32)9-31-17(22(23,24)25)3-4-29-19(33)6-18(28-21(29)31)30-8-14-5-13(30)10-34-14/h6-7,13-14,17H,3-5,8-10H2,1-2H3,(H2,26,27)/t13-,14-,17-/m0/s1
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US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226236
PNG
(US9321790, 48)
Show SMILES Fc1ccc(C(=O)CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H19F5N4O3/c22-11-1-2-14(15(23)5-11)16(31)9-30-17(21(24,25)26)3-4-28-19(32)7-18(27-20(28)30)29-8-13-6-12(29)10-33-13/h1-2,5,7,12-13,17H,3-4,6,8-10H2/t12-,13-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226245
PNG
(US9321790, 57)
Show SMILES CCOC(=O)Nc1ccc(cn1)C(=O)CN1C(CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C23H25F3N6O5/c1-2-36-22(35)28-18-4-3-13(9-27-18)16(33)11-32-17(23(24,25)26)5-6-30-20(34)8-19(29-21(30)32)31-10-15-7-14(31)12-37-15/h3-4,8-9,14-15,17H,2,5-7,10-12H2,1H3,(H,27,28,35)/t14-,15-,17?/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226298
PNG
(US9321790, 110)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)N1CCOCC1
Show InChI InChI=1S/C19H24F3N5O4/c20-19(21,22)14-1-2-25-16(28)8-15(26-9-13-7-12(26)11-31-13)23-18(25)27(14)10-17(29)24-3-5-30-6-4-24/h8,12-14H,1-7,9-11H2/t12-,13-,14-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226192
PNG
(US9321790, 4)
Show SMILES Cc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O3/c1-12-2-3-13(8-25-12)16(30)10-29-17(21(22,23)24)4-5-27-19(31)7-18(26-20(27)29)28-9-15-6-14(28)11-32-15/h2-3,7-8,14-15,17H,4-6,9-11H2,1H3/t14-,15-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226206
PNG
(US9321790, 18)
Show SMILES Cc1ncccc1C(=O)CN1c2nc(cc(=O)n2CC1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2
Show InChI InChI=1S/C21H22F3N5O3/c1-12-15(4-3-5-25-12)16(30)9-29-19-26-17(27-8-14-6-13(27)10-32-14)7-18(31)28(19)11-20(29,2)21(22,23)24/h3-5,7,13-14H,6,8-11H2,1-2H3/t13-,14-,20?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226207
PNG
(US9321790, 19)
Show SMILES Cc1ncccc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O3/c1-12-15(3-2-5-25-12)16(30)10-29-17(21(22,23)24)4-6-27-19(31)8-18(26-20(27)29)28-9-14-7-13(28)11-32-14/h2-3,5,8,13-14,17H,4,6-7,9-11H2,1H3/t13-,14-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226241
PNG
(US9321790, 53)
Show SMILES Cc1noc(C)c1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C20H22F3N5O4/c1-10-18(11(2)32-25-10)14(29)8-28-15(20(21,22)23)3-4-26-17(30)6-16(24-19(26)28)27-7-13-5-12(27)9-31-13/h6,12-13,15H,3-5,7-9H2,1-2H3/t12-,13-,15-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226257
PNG
(US9321790, 69)
Show SMILES Cn1nccc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C19H21F3N6O3/c1-25-13(2-4-23-25)14(29)9-28-15(19(20,21)22)3-5-26-17(30)7-16(24-18(26)28)27-8-12-6-11(27)10-31-12/h2,4,7,11-12,15H,3,5-6,8-10H2,1H3/t11-,12-,15-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226254
PNG
(US9321790, 66)
Show SMILES Cn1cncc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C19H21F3N6O3/c1-25-10-23-6-13(25)14(29)8-28-15(19(20,21)22)2-3-26-17(30)5-16(24-18(26)28)27-7-12-4-11(27)9-31-12/h5-6,10-12,15H,2-4,7-9H2,1H3/t11-,12-,15-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226249
PNG
(US9321790, 61)
Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc2nsnc2c1
Show InChI InChI=1S/C21H19F3N6O3S/c22-21(23,24)17-3-4-28-19(32)7-18(29-8-13-6-12(29)10-33-13)25-20(28)30(17)9-16(31)11-1-2-14-15(5-11)27-34-26-14/h1-2,5,7,12-13,17H,3-4,6,8-10H2/t12-,13-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226228
PNG
(US9321790, 40)
Show SMILES Fc1ccc(cc1F)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F
Show InChI InChI=1S/C21H19F5N4O3/c22-14-2-1-11(5-15(14)23)16(31)9-30-17(21(24,25)26)3-4-28-19(32)7-18(27-20(28)30)29-8-13-6-12(29)10-33-13/h1-2,5,7,12-13,17H,3-4,6,8-10H2/t12-,13-,17-/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226199
PNG
(US9321790, 11)
Show SMILES C[C@]1(Cn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc(N)nc1)C(F)(F)F
Show InChI InChI=1S/C20H21F3N6O3/c1-19(20(21,22)23)10-28-17(31)5-16(27-7-13-4-12(27)9-32-13)26-18(28)29(19)8-14(30)11-2-3-15(24)25-6-11/h2-3,5-6,12-13H,4,7-10H2,1H3,(H2,24,25)/t12-,13-,19-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM226221
PNG
(US9321790, 33)
Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C21H19F6N5O3/c22-20(23,24)15-2-1-11(7-28-15)14(33)9-32-16(21(25,26)27)3-4-30-18(34)6-17(29-19(30)32)31-8-13-5-12(31)10-35-13/h1-2,6-7,12-13,16H,3-5,8-10H2/t12-,13-,16?/m0/s1
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Sanofi

US Patent


Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%