BindingDB logo
myBDB logout

Patent code US9328111

Compile Data Set for Download or QSAR
Found 39 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)


(Homo sapiens (Human))
BDBM224640
PNG
(US9328111, 13)
Show SMILES CC(C)(C)OC(=O)N1CCc2c(C1)[nH]c1cccc3c1c2n[nH]c3=O
Show InChI InChI=1S/C18H20N4O3/c1-18(2,3)25-17(24)22-8-7-10-13(9-22)19-12-6-4-5-11-14(12)15(10)20-21-16(11)23/h4-6,19H,7-9H2,1-3H3,(H,21,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP2 and PARP3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with th...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)


(Homo sapiens (Human))
BDBM224628
PNG
(US9328111, 1)
Show SMILES CC1(C)CCc2[nH]c3cccc4c3c(n[nH]c4=O)c2C1
Show InChI InChI=1S/C16H17N3O/c1-16(2)7-6-11-10(8-16)14-13-9(15(20)19-18-14)4-3-5-12(13)17-11/h3-5,17H,6-8H2,1-2H3,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.700n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP2 and PARP3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with th...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)


(Homo sapiens (Human))
BDBM224630
PNG
(US9328111, 3)
Show SMILES O=c1[nH]nc2c3CCCCCCc3[nH]c3cccc1c23
Show InChI InChI=1S/C16H17N3O/c20-16-11-7-5-9-13-14(11)15(18-19-16)10-6-3-1-2-4-8-12(10)17-13/h5,7,9,17H,1-4,6,8H2,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.730n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP2 and PARP3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with th...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)


(Homo sapiens (Human))
BDBM224629
PNG
(US9328111, 2)
Show SMILES O=c1[nH]nc2c3CCCCc3[nH]c3cccc1c23
Show InChI InChI=1S/C14H13N3O/c18-14-9-5-3-7-11-12(9)13(16-17-14)8-4-1-2-6-10(8)15-11/h3,5,7,15H,1-2,4,6H2,(H,17,18)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.770n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP2 and PARP3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with th...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)


(Homo sapiens (Human))
BDBM224631
PNG
(US9328111, 4)
Show SMILES O=c1[nH]nc2c3CCCCCc3[nH]c3cccc1c23
Show InChI InChI=1S/C15H15N3O/c19-15-10-6-4-8-12-13(10)14(17-18-15)9-5-2-1-3-7-11(9)16-12/h4,6,8,16H,1-3,5,7H2,(H,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP2 and PARP3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with th...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)


(Homo sapiens (Human))
BDBM224641
PNG
(US9328111, 14)
Show SMILES O=c1[nH]nc2c3CCNCc3[nH]c3cccc1c23
Show InChI InChI=1S/C13H12N4O/c18-13-8-2-1-3-9-11(8)12(16-17-13)7-4-5-14-6-10(7)15-9/h1-3,14-15H,4-6H2,(H,17,18)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP2 and PARP3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with th...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)


(Homo sapiens (Human))
BDBM224645
PNG
(US9328111, 18)
Show SMILES O=c1[nH]nc2c3CCN(Cc4ccccc4)Cc3[nH]c3cccc1c23
Show InChI InChI=1S/C20H18N4O/c25-20-15-7-4-8-16-18(15)19(22-23-20)14-9-10-24(12-17(14)21-16)11-13-5-2-1-3-6-13/h1-8,21H,9-12H2,(H,23,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP2 and PARP3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with th...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM224629
PNG
(US9328111, 2)
Show SMILES O=c1[nH]nc2c3CCCCc3[nH]c3cccc1c23
Show InChI InChI=1S/C14H13N3O/c18-14-9-5-3-7-11-12(9)13(16-17-14)8-4-1-2-6-10(8)15-11/h3,5,7,15H,1-2,4,6H2,(H,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.20n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224631
PNG
(US9328111, 4)
Show SMILES O=c1[nH]nc2c3CCCCCc3[nH]c3cccc1c23
Show InChI InChI=1S/C15H15N3O/c19-15-10-6-4-8-12-13(10)14(17-18-15)9-5-2-1-3-7-11(9)16-12/h4,6,8,16H,1-3,5,7H2,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.90n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224640
PNG
(US9328111, 13)
Show SMILES CC(C)(C)OC(=O)N1CCc2c(C1)[nH]c1cccc3c1c2n[nH]c3=O
Show InChI InChI=1S/C18H20N4O3/c1-18(2,3)25-17(24)22-8-7-10-13(9-22)19-12-6-4-5-11-14(12)15(10)20-21-16(11)23/h4-6,19H,7-9H2,1-3H3,(H,21,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.10n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224630
PNG
(US9328111, 3)
Show SMILES O=c1[nH]nc2c3CCCCCCc3[nH]c3cccc1c23
Show InChI InChI=1S/C16H17N3O/c20-16-11-7-5-9-13-14(11)15(18-19-16)10-6-3-1-2-4-8-12(10)17-13/h5,7,9,17H,1-4,6,8H2,(H,19,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.90n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224637
PNG
(US9328111, 10)
Show SMILES O=c1[nH]nc2c3CCCc3[nH]c3cccc1c23
Show InChI InChI=1S/C13H11N3O/c17-13-8-4-2-6-10-11(8)12(15-16-13)7-3-1-5-9(7)14-10/h2,4,6,14H,1,3,5H2,(H,16,17)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224629
PNG
(US9328111, 2)
Show SMILES O=c1[nH]nc2c3CCCCc3[nH]c3cccc1c23
Show InChI InChI=1S/C14H13N3O/c18-14-9-5-3-7-11-12(9)13(16-17-14)8-4-1-2-6-10(8)15-11/h3,5,7,15H,1-2,4,6H2,(H,17,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.10n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224628
PNG
(US9328111, 1)
Show SMILES CC1(C)CCc2[nH]c3cccc4c3c(n[nH]c4=O)c2C1
Show InChI InChI=1S/C16H17N3O/c1-16(2)7-6-11-10(8-16)14-13-9(15(20)19-18-14)4-3-5-12(13)17-11/h3-5,17H,6-8H2,1-2H3,(H,19,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.30n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM224640
PNG
(US9328111, 13)
Show SMILES CC(C)(C)OC(=O)N1CCc2c(C1)[nH]c1cccc3c1c2n[nH]c3=O
Show InChI InChI=1S/C18H20N4O3/c1-18(2,3)25-17(24)22-8-7-10-13(9-22)19-12-6-4-5-11-14(12)15(10)20-21-16(11)23/h4-6,19H,7-9H2,1-3H3,(H,21,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224643
PNG
(US9328111, 16)
Show SMILES CC1(CC1)C(=O)N1CCc2c(C1)[nH]c1cccc3c1c2n[nH]c3=O
Show InChI InChI=1S/C18H18N4O2/c1-18(6-7-18)17(24)22-8-5-10-13(9-22)19-12-4-2-3-11-14(12)15(10)20-21-16(11)23/h2-4,19H,5-9H2,1H3,(H,21,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.20n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224641
PNG
(US9328111, 14)
Show SMILES O=c1[nH]nc2c3CCNCc3[nH]c3cccc1c23
Show InChI InChI=1S/C13H12N4O/c18-13-8-2-1-3-9-11(8)12(16-17-13)7-4-5-14-6-10(7)15-9/h1-3,14-15H,4-6H2,(H,17,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.60n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224644
PNG
(US9328111, 17)
Show SMILES CC1(C)C(C(=O)N2CCc3c(C2)[nH]c2cccc4c2c3n[nH]c4=O)C1(C)C
Show InChI InChI=1S/C21H24N4O2/c1-20(2)17(21(20,3)4)19(27)25-9-8-11-14(10-25)22-13-7-5-6-12-15(13)16(11)23-24-18(12)26/h5-7,17,22H,8-10H2,1-4H3,(H,24,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224645
PNG
(US9328111, 18)
Show SMILES O=c1[nH]nc2c3CCN(Cc4ccccc4)Cc3[nH]c3cccc1c23
Show InChI InChI=1S/C20H18N4O/c25-20-15-7-4-8-16-18(15)19(22-23-20)14-9-10-24(12-17(14)21-16)11-13-5-2-1-3-6-13/h1-8,21H,9-12H2,(H,23,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.70n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224636
PNG
(US9328111, 9)
Show SMILES Clc1ccc2c3c(n[nH]c2=O)c2CCCCc2[nH]c13
Show InChI InChI=1S/C14H12ClN3O/c15-9-6-5-8-11-12(17-18-14(8)19)7-3-1-2-4-10(7)16-13(9)11/h5-6,16H,1-4H2,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 10.3n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM224630
PNG
(US9328111, 3)
Show SMILES O=c1[nH]nc2c3CCCCCCc3[nH]c3cccc1c23
Show InChI InChI=1S/C16H17N3O/c20-16-11-7-5-9-13-14(11)15(18-19-16)10-6-3-1-2-4-8-12(10)17-13/h5,7,9,17H,1-4,6,8H2,(H,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM224631
PNG
(US9328111, 4)
Show SMILES O=c1[nH]nc2c3CCCCCc3[nH]c3cccc1c23
Show InChI InChI=1S/C15H15N3O/c19-15-10-6-4-8-12-13(10)14(17-18-15)9-5-2-1-3-7-11(9)16-12/h4,6,8,16H,1-3,5,7H2,(H,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 15.4n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM224628
PNG
(US9328111, 1)
Show SMILES CC1(C)CCc2[nH]c3cccc4c3c(n[nH]c4=O)c2C1
Show InChI InChI=1S/C16H17N3O/c1-16(2)7-6-11-10(8-16)14-13-9(15(20)19-18-14)4-3-5-12(13)17-11/h3-5,17H,6-8H2,1-2H3,(H,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 15.6n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224634
PNG
(US9328111, 7)
Show SMILES Brc1ccc2c3c(n[nH]c2=O)c2CCCCc2[nH]c13
Show InChI InChI=1S/C14H12BrN3O/c15-9-6-5-8-11-12(17-18-14(8)19)7-3-1-2-4-10(7)16-13(9)11/h5-6,16H,1-4H2,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 17n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM224637
PNG
(US9328111, 10)
Show SMILES O=c1[nH]nc2c3CCCc3[nH]c3cccc1c23
Show InChI InChI=1S/C13H11N3O/c17-13-8-4-2-6-10-11(8)12(15-16-13)7-3-1-5-9(7)14-10/h2,4,6,14H,1,3,5H2,(H,16,17)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 17.5n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)


(Homo sapiens (Human))
BDBM224641
PNG
(US9328111, 14)
Show SMILES O=c1[nH]nc2c3CCNCc3[nH]c3cccc1c23
Show InChI InChI=1S/C13H12N4O/c18-13-8-2-1-3-9-11(8)12(16-17-13)7-4-5-14-6-10(7)15-9/h1-3,14-15H,4-6H2,(H,17,18)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP2 and PARP3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with th...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)


(Homo sapiens (Human))
BDBM224628
PNG
(US9328111, 1)
Show SMILES CC1(C)CCc2[nH]c3cccc4c3c(n[nH]c4=O)c2C1
Show InChI InChI=1S/C16H17N3O/c1-16(2)7-6-11-10(8-16)14-13-9(15(20)19-18-14)4-3-5-12(13)17-11/h3-5,17H,6-8H2,1-2H3,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP2 and PARP3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with th...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224642
PNG
(US9328111, 15)
Show SMILES CC(C)(NC(=O)OCc1ccccc1)C(=O)N1CCc2c(C1)[nH]c1cccc3c1c2n[nH]c3=O
Show InChI InChI=1S/C25H25N5O4/c1-25(2,27-24(33)34-14-15-7-4-3-5-8-15)23(32)30-12-11-16-19(13-30)26-18-10-6-9-17-20(18)21(16)28-29-22(17)31/h3-10,26H,11-14H2,1-2H3,(H,27,33)(H,29,31)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 23n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)


(Homo sapiens (Human))
BDBM224630
PNG
(US9328111, 3)
Show SMILES O=c1[nH]nc2c3CCCCCCc3[nH]c3cccc1c23
Show InChI InChI=1S/C16H17N3O/c20-16-11-7-5-9-13-14(11)15(18-19-16)10-6-3-1-2-4-8-12(10)17-13/h5,7,9,17H,1-4,6,8H2,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP2 and PARP3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with th...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)


(Homo sapiens (Human))
BDBM224631
PNG
(US9328111, 4)
Show SMILES O=c1[nH]nc2c3CCCCCc3[nH]c3cccc1c23
Show InChI InChI=1S/C15H15N3O/c19-15-10-6-4-8-12-13(10)14(17-18-15)9-5-2-1-3-7-11(9)16-12/h4,6,8,16H,1-3,5,7H2,(H,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 30.3n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP2 and PARP3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with th...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM224645
PNG
(US9328111, 18)
Show SMILES O=c1[nH]nc2c3CCN(Cc4ccccc4)Cc3[nH]c3cccc1c23
Show InChI InChI=1S/C20H18N4O/c25-20-15-7-4-8-16-18(15)19(22-23-20)14-9-10-24(12-17(14)21-16)11-13-5-2-1-3-6-13/h1-8,21H,9-12H2,(H,23,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 43n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224635
PNG
(US9328111, 8)
Show SMILES Clc1ccc2c3c(n[nH]c2=O)c2CCCCCc2[nH]c13
Show InChI InChI=1S/C15H14ClN3O/c16-10-7-6-9-12-13(18-19-15(9)20)8-4-2-1-3-5-11(8)17-14(10)12/h6-7,17H,1-5H2,(H,19,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 52.5n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224639
PNG
(US9328111, 12)
Show SMILES O=c1[nH]nc2c-3c(CCc4ccccc-34)[nH]c3cccc1c23
Show InChI InChI=1S/C18H13N3O/c22-18-12-6-3-7-13-16(12)17(20-21-18)15-11-5-2-1-4-10(11)8-9-14(15)19-13/h1-7,19H,8-9H2,(H,21,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 54.6n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224638
PNG
(US9328111, 11)
Show SMILES CC(=O)NNc1cc2[nH]c3CCCCCc3c3n[nH]c(=O)c(c1)c23
Show InChI InChI=1S/C17H19N5O2/c1-9(23)19-20-10-7-12-15-14(8-10)18-13-6-4-2-3-5-11(13)16(15)21-22-17(12)24/h7-8,18,20H,2-6H2,1H3,(H,19,23)(H,22,24)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 59n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224633
PNG
(US9328111, 6)
Show SMILES Brc1ccc2c3c(n[nH]c2=O)c2CCCCCc2[nH]c13
Show InChI InChI=1S/C15H14BrN3O/c16-10-7-6-9-12-13(18-19-15(9)20)8-4-2-1-3-5-11(8)17-14(10)12/h6-7,17H,1-5H2,(H,19,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 67n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM224632
PNG
(US9328111, 5)
Show SMILES Cc1ccc2c3c(n[nH]c2=O)c2CCCCc2[nH]c13
Show InChI InChI=1S/C15H15N3O/c1-8-6-7-10-12-13(8)16-11-5-3-2-4-9(11)14(12)17-18-15(10)19/h6-7,16H,2-5H2,1H3,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 70.7n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP1 was pre-incubate...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b)


(Homo sapiens (Human))
BDBM224641
PNG
(US9328111, 14)
Show SMILES O=c1[nH]nc2c3CCNCc3[nH]c3cccc1c23
Show InChI InChI=1S/C13H12N4O/c18-13-8-2-1-3-9-11(8)12(16-17-13)7-4-5-14-6-10(7)15-9/h1-3,14-15H,4-6H2,(H,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 120n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)


(Homo sapiens (Human))
BDBM224640
PNG
(US9328111, 13)
Show SMILES CC(C)(C)OC(=O)N1CCc2c(C1)[nH]c1cccc3c1c2n[nH]c3=O
Show InChI InChI=1S/C18H20N4O3/c1-18(2,3)25-17(24)22-8-7-10-13(9-22)19-12-6-4-5-11-14(12)15(10)20-21-16(11)23/h4-6,19H,7-9H2,1-3H3,(H,21,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 270n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP2 and PARP3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with th...


Citation and Details
More data for this
Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)


(Homo sapiens (Human))
BDBM224645
PNG
(US9328111, 18)
Show SMILES O=c1[nH]nc2c3CCN(Cc4ccccc4)Cc3[nH]c3cccc1c23
Show InChI InChI=1S/C20H18N4O/c25-20-15-7-4-8-16-18(15)19(22-23-20)14-9-10-24(12-17(14)21-16)11-13-5-2-1-3-6-13/h1-8,21H,9-12H2,(H,23,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



BeiGene Ltd.

US Patent


Assay Description
PARP2 and PARP3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with th...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%