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Patent code US9328112

Compile Data Set for Download or QSAR
Found 193 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223792
PNG
(US9328112, 14)
Show SMILES Fc1ccc2OCc3c([nH]c4nccc(-c2c1)c34)C1=CCNCC1
Show InChI InChI=1S/C19H16FN3O/c20-12-1-2-16-14(9-12)13-5-8-22-19-17(13)15(10-24-16)18(23-19)11-3-6-21-7-4-11/h1-3,5,8-9,21H,4,6-7,10H2,(H,22,23)
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n/an/a 20n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223779
PNG
(US9328112, 1)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCNCC1
Show InChI InChI=1S/C20H19FN4/c1-25-11-16-18-14(15-10-13(21)2-3-17(15)25)6-9-23-20(18)24-19(16)12-4-7-22-8-5-12/h2-4,6,9-10,22H,5,7-8,11H2,1H3,(H,23,24)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223803
PNG
(US9328112, 25)
Show SMILES CNS(=O)(=O)CC(=O)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C23H24FN5O3S/c1-25-33(31,32)13-20(30)29-9-6-14(7-10-29)22-18-12-28(2)19-4-3-15(24)11-17(19)16-5-8-26-23(27-22)21(16)18/h3-6,8,11,25H,7,9-10,12-13H2,1-2H3,(H,26,27)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223957
PNG
(US9328112, 179)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CCS(N)(=O)=O)CC1
Show InChI InChI=1S/C22H24FN5O2S/c1-27-13-18-20-16(17-12-15(23)2-3-19(17)27)4-7-25-22(20)26-21(18)14-5-8-28(9-6-14)10-11-31(24,29)30/h2-5,7,12H,6,8-11,13H2,1H3,(H,25,26)(H2,24,29,30)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223782
PNG
(US9328112, 4)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C21H21FN4O2S/c1-25-12-17-19-15(16-11-14(22)3-4-18(16)25)5-8-23-21(19)24-20(17)13-6-9-26(10-7-13)29(2,27)28/h3-6,8,11H,7,9-10,12H2,1-2H3,(H,23,24)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223956
PNG
(US9328112, 178)
Show SMILES CN(C)S(=O)(=O)CCN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C24H28FN5O2S/c1-28(2)33(31,32)13-12-30-10-7-16(8-11-30)23-20-15-29(3)21-5-4-17(25)14-19(21)18-6-9-26-24(27-23)22(18)20/h4-7,9,14H,8,10-13,15H2,1-3H3,(H,26,27)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223905
PNG
(US9328112, 127)
Show SMILES CN1CCc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCNCC1
Show InChI InChI=1S/C21H21FN4/c1-26-11-7-16-19-15(17-12-14(22)2-3-18(17)26)6-10-24-21(19)25-20(16)13-4-8-23-9-5-13/h2-4,6,10,12,23H,5,7-9,11H2,1H3,(H,24,25)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223826
PNG
(US9328112, 48)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCNCC1
Show InChI InChI=1S/C20H18F2N4/c1-26-10-14-18-17(13-8-12(21)2-3-16(13)26)15(22)9-24-20(18)25-19(14)11-4-6-23-7-5-11/h2-4,8-9,23H,5-7,10H2,1H3,(H,24,25)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223932
PNG
(US9328112, 154)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@H](CO)NCC1
Show InChI InChI=1S/C21H21FN4O/c1-26-10-17-19-15(16-9-13(22)2-3-18(16)26)5-7-24-21(19)25-20(17)12-4-6-23-14(8-12)11-27/h2-3,5,7-9,14,23,27H,4,6,10-11H2,1H3,(H,24,25)/t14-/m1/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223922
PNG
(US9328112, 144)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCNCC1
Show InChI InChI=1S/C20H18F2N4/c1-26-10-14-18-12(13-8-15(21)16(22)9-17(13)26)4-7-24-20(18)25-19(14)11-2-5-23-6-3-11/h2,4,7-9,23H,3,5-6,10H2,1H3,(H,24,25)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223934
PNG
(US9328112, 156)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN[C@@H](CO)C1
Show InChI InChI=1S/C21H21FN4O/c1-26-10-17-19-15(16-9-13(22)2-3-18(16)26)5-7-24-21(19)25-20(17)12-4-6-23-14(8-12)11-27/h2-5,7,9,14,23,27H,6,8,10-11H2,1H3,(H,24,25)/t14-/m1/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223791
PNG
(US9328112, 13)
Show SMILES CNC(=O)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C22H22FN5O/c1-24-22(29)28-9-6-13(7-10-28)20-17-12-27(2)18-4-3-14(23)11-16(18)15-5-8-25-21(26-20)19(15)17/h3-6,8,11H,7,9-10,12H2,1-2H3,(H,24,29)(H,25,26)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223920
PNG
(US9328112, 142)
Show SMILES CC[C@@H]1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCNCC1
Show InChI InChI=1S/C22H23FN4/c1-3-17-20-19-15(16-12-14(23)4-5-18(16)27(17)2)8-11-25-22(19)26-21(20)13-6-9-24-10-7-13/h4-6,8,11-12,17,24H,3,7,9-10H2,1-2H3,(H,25,26)/t17-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223937
PNG
(US9328112, 159)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4ccccc14)c23)C1=CCNCC1
Show InChI InChI=1S/C20H19FN4/c1-25-11-14-18-17(13-4-2-3-5-16(13)25)15(21)10-23-20(18)24-19(14)12-6-8-22-9-7-12/h2-6,10,22H,7-9,11H2,1H3,(H,23,24)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223909
PNG
(US9328112, 131)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C21H20F2N4O2S/c1-26-11-15-19-13(14-9-16(22)17(23)10-18(14)26)3-6-24-21(19)25-20(15)12-4-7-27(8-5-12)30(2,28)29/h3-4,6,9-10H,5,7-8,11H2,1-2H3,(H,24,25)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223929
PNG
(US9328112, 151)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@@H]2COC(=O)N2CC1
Show InChI InChI=1S/C22H19FN4O2/c1-26-10-17-19-15(16-9-13(23)2-3-18(16)26)4-6-24-21(19)25-20(17)12-5-7-27-14(8-12)11-29-22(27)28/h2-4,6,8-9,14H,5,7,10-11H2,1H3,(H,24,25)/t14-/m1/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223846
PNG
(US9328112, 68)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C21H20F2N4O2S/c1-26-11-15-19-18(14-9-13(22)3-4-17(14)26)16(23)10-24-21(19)25-20(15)12-5-7-27(8-6-12)30(2,28)29/h3-5,9-10H,6-8,11H2,1-2H3,(H,24,25)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223841
PNG
(US9328112, 63)
Show SMILES CN(CC(O)CO)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C26H30FN5O3/c1-30-13-21-24-19(20-11-17(27)3-4-22(20)30)5-8-28-26(24)29-25(21)16-6-9-32(10-7-16)14-23(35)31(2)12-18(34)15-33/h3-6,8,11,18,33-34H,7,9-10,12-15H2,1-2H3,(H,28,29)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223910
PNG
(US9328112, 132)
Show SMILES CN(C)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)c(F)cc4N(C)Cc1c23
Show InChI InChI=1S/C24H25F2N5O/c1-29(2)21(32)13-31-8-5-14(6-9-31)23-17-12-30(3)20-11-19(26)18(25)10-16(20)15-4-7-27-24(28-23)22(15)17/h4-5,7,10-11H,6,8-9,12-13H2,1-3H3,(H,27,28)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223939
PNG
(US9328112, 161)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4ccccc14)c23)C1=CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C21H21FN4O2S/c1-25-12-15-19-18(14-5-3-4-6-17(14)25)16(22)11-23-21(19)24-20(15)13-7-9-26(10-8-13)29(2,27)28/h3-7,11H,8-10,12H2,1-2H3,(H,23,24)
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223802
PNG
(US9328112, 24)
Show SMILES CN(C1CC(O)C1)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C27H30FN5O2/c1-31-14-22-25-20(21-11-17(28)3-4-23(21)31)5-8-29-27(25)30-26(22)16-6-9-33(10-7-16)15-24(35)32(2)18-12-19(34)13-18/h3-6,8,11,18-19,34H,7,9-10,12-15H2,1-2H3,(H,29,30)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223930
PNG
(US9328112, 152)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@H]2COC(=O)N2CC1
Show InChI InChI=1S/C22H19FN4O2/c1-26-10-17-19-15(16-9-13(23)2-3-18(16)26)4-6-24-21(19)25-20(17)12-5-7-27-14(8-12)11-29-22(27)28/h2-4,6,8-9,14H,5,7,10-11H2,1H3,(H,24,25)/t14-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223933
PNG
(US9328112, 155)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@@H](CO)NCC1
Show InChI InChI=1S/C21H21FN4O/c1-26-10-17-19-15(16-9-13(22)2-3-18(16)26)5-7-24-21(19)25-20(17)12-4-6-23-14(8-12)11-27/h2-3,5,7-9,14,23,27H,4,6,10-11H2,1H3,(H,24,25)/t14-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223854
PNG
(US9328112, 76)
Show SMILES CNC(=O)N1CC2CC(=CC2C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C24H24FN5O/c1-26-24(31)30-10-14-7-13(8-15(14)11-30)22-19-12-29(2)20-4-3-16(25)9-18(20)17-5-6-27-23(28-22)21(17)19/h3-7,9,14-15H,8,10-12H2,1-2H3,(H,26,31)(H,27,28)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223918
PNG
(US9328112, 140)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CC(CC(O)=O)C1
Show InChI InChI=1S/C26H27FN4O2/c1-30-14-21-24-19(20-13-17(27)2-3-22(20)30)4-7-28-26(24)29-25(21)16-5-8-31(9-6-16)18-10-15(11-18)12-23(32)33/h2-5,7,13,15,18H,6,8-12,14H2,1H3,(H,28,29)(H,32,33)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223923
PNG
(US9328112, 145)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCN(CC(O)=O)CC1
Show InChI InChI=1S/C22H20F2N4O2/c1-27-10-15-20-13(14-8-16(23)17(24)9-18(14)27)2-5-25-22(20)26-21(15)12-3-6-28(7-4-12)11-19(29)30/h2-3,5,8-9H,4,6-7,10-11H2,1H3,(H,25,26)(H,29,30)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223887
PNG
(US9328112, 109)
Show SMILES CN(C1CC(O)C1)C(=O)CN1CCC(=CC1)c1[nH]c2ncc(F)c3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C27H29F2N5O2/c1-32-13-20-25-24(19-9-16(28)3-4-22(19)32)21(29)12-30-27(25)31-26(20)15-5-7-34(8-6-15)14-23(36)33(2)17-10-18(35)11-17/h3-5,9,12,17-18,35H,6-8,10-11,13-14H2,1-2H3,(H,30,31)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223864
PNG
(US9328112, 86)
Show SMILES CN(CCO)C(=O)CN1CC2CC(=CC2C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C27H30FN5O2/c1-31(7-8-34)24(35)15-33-12-17-9-16(10-18(17)13-33)26-22-14-32(2)23-4-3-19(28)11-21(23)20-5-6-29-27(30-26)25(20)22/h3-6,9,11,17-18,34H,7-8,10,12-15H2,1-2H3,(H,29,30)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223844
PNG
(US9328112, 66)
Show SMILES CN(C)C(=O)CN1CCC(=CC1)c1[nH]c2ncc(F)c3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C24H25F2N5O/c1-29(2)20(32)13-31-8-6-14(7-9-31)23-17-12-30(3)19-5-4-15(25)10-16(19)21-18(26)11-27-24(28-23)22(17)21/h4-6,10-11H,7-9,12-13H2,1-3H3,(H,27,28)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223796
PNG
(US9328112, 18)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CC(O)C2)CC1
Show InChI InChI=1S/C25H26FN5O2/c1-29-13-20-23-18(19-10-16(26)2-3-21(19)29)4-7-27-25(23)28-24(20)15-5-8-30(9-6-15)14-22(33)31-11-17(32)12-31/h2-5,7,10,17,32H,6,8-9,11-14H2,1H3,(H,27,28)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223880
PNG
(US9328112, 102)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CCCC(C1)N2C(=O)CC#N
Show InChI InChI=1S/C26H24FN5O/c1-31-14-21-24-19(20-13-16(27)5-6-22(20)31)8-10-29-26(24)30-25(21)15-11-17-3-2-4-18(12-15)32(17)23(33)7-9-28/h5-6,8,10-11,13,17-18H,2-4,7,12,14H2,1H3,(H,29,30)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223888
PNG
(US9328112, 110)
Show SMILES CN(CC(O)CO)C(=O)CN1CCC(=CC1)c1[nH]c2ncc(F)c3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C26H29F2N5O3/c1-31-12-19-24-23(18-9-16(27)3-4-21(18)31)20(28)10-29-26(24)30-25(19)15-5-7-33(8-6-15)13-22(36)32(2)11-17(35)14-34/h3-5,9-10,17,34-35H,6-8,11-14H2,1-2H3,(H,29,30)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223925
PNG
(US9328112, 147)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCN(CC(=O)N2CCC[C@H]2CO)CC1
Show InChI InChI=1S/C27H29F2N5O2/c1-32-13-20-25-18(19-11-21(28)22(29)12-23(19)32)4-7-30-27(25)31-26(20)16-5-9-33(10-6-16)14-24(36)34-8-2-3-17(34)15-35/h4-5,7,11-12,17,35H,2-3,6,8-10,13-15H2,1H3,(H,30,31)/t17-/m0/s1
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223951
PNG
(US9328112, 173)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CCC(CC1)=CC#N
Show InChI InChI=1S/C28H28FN5/c1-33-17-24-26-22(23-16-20(29)4-7-25(23)33)9-13-31-28(26)32-27(24)19-10-14-34(15-11-19)21-5-2-18(3-6-21)8-12-30/h4,7-10,13,16,21H,2-3,5-6,11,14-15,17H2,1H3,(H,31,32)/b18-8-
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223935
PNG
(US9328112, 157)
Show SMILES CN(CCO)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)c(F)cc4N(C)Cc1c23
Show InChI InChI=1S/C25H27F2N5O2/c1-30(9-10-33)22(34)14-32-7-4-15(5-8-32)24-18-13-31(2)21-12-20(27)19(26)11-17(21)16-3-6-28-25(29-24)23(16)18/h3-4,6,11-12,33H,5,7-10,13-14H2,1-2H3,(H,28,29)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223807
PNG
(US9328112, 29)
Show SMILES CC(C)[C@@H](NC1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23)C(O)=O
Show InChI InChI=1S/C26H29FN4O2/c1-14(2)23(26(32)33)29-17-7-4-15(5-8-17)24-20-13-31(3)21-9-6-16(27)12-19(21)18-10-11-28-25(30-24)22(18)20/h4,6,9-12,14,17,23,29H,5,7-8,13H2,1-3H3,(H,28,30)(H,32,33)/t17?,23-/m1/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223855
PNG
(US9328112, 77)
Show SMILES CN(C)C(=O)CN1CC2CC(=CC2C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C26H28FN5O/c1-30(2)23(33)14-32-11-16-8-15(9-17(16)12-32)25-21-13-31(3)22-5-4-18(27)10-20(22)19-6-7-28-26(29-25)24(19)21/h4-8,10,16-17H,9,11-14H2,1-3H3,(H,28,29)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223871
PNG
(US9328112, 93)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCNC1
Show InChI InChI=1S/C20H19FN4/c1-25-11-16-18-14(15-9-13(21)4-5-17(15)25)6-8-23-20(18)24-19(16)12-3-2-7-22-10-12/h3-6,8-9,22H,2,7,10-11H2,1H3,(H,23,24)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223840
PNG
(US9328112, 62)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@H]2CC[C@@H](C1)N2
Show InChI InChI=1S/C22H21FN4/c1-27-11-18-20-16(17-10-13(23)2-5-19(17)27)6-7-24-22(20)26-21(18)12-8-14-3-4-15(9-12)25-14/h2,5-8,10,14-15,25H,3-4,9,11H2,1H3,(H,24,26)/t14-,15+/m1/s1
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223912
PNG
(US9328112, 134)
Show SMILES COC(=O)CC1CC[C@@H](CC1)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)c(F)cc4N(C)Cc1c23
Show InChI InChI=1S/C29H32F2N4O2/c1-34-16-22-27-20(21-14-23(30)24(31)15-25(21)34)7-10-32-29(27)33-28(22)18-8-11-35(12-9-18)19-5-3-17(4-6-19)13-26(36)37-2/h7-8,10,14-15,17,19H,3-6,9,11-13,16H2,1-2H3,(H,32,33)/t17?,19-
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223781
PNG
(US9328112, 3)
Show SMILES CCOC(=O)NS(=O)(=O)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C23H24FN5O4S/c1-3-33-23(30)27-34(31,32)29-10-7-14(8-11-29)21-18-13-28(2)19-5-4-15(24)12-17(19)16-6-9-25-22(26-21)20(16)18/h4-7,9,12H,3,8,10-11,13H2,1-2H3,(H,25,26)(H,27,30)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223845
PNG
(US9328112, 67)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC(O)=O)CC1
Show InChI InChI=1S/C22H20F2N4O2/c1-27-10-15-20-19(14-8-13(23)2-3-17(14)27)16(24)9-25-22(20)26-21(15)12-4-6-28(7-5-12)11-18(29)30/h2-4,8-9H,5-7,10-11H2,1H3,(H,25,26)(H,29,30)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223787
PNG
(US9328112, 9)
Show SMILES CCC1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCNCC1
Show InChI InChI=1S/C22H23FN4/c1-3-17-20-19-15(16-12-14(23)4-5-18(16)27(17)2)8-11-25-22(19)26-21(20)13-6-9-24-10-7-13/h4-6,8,11-12,17,24H,3,7,9-10H2,1-2H3,(H,25,26)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223820
PNG
(US9328112, 42)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CC[C@H](O)C2)CC1
Show InChI InChI=1S/C26H28FN5O2/c1-30-14-21-24-19(20-12-17(27)2-3-22(20)30)4-8-28-26(24)29-25(21)16-5-9-31(10-6-16)15-23(34)32-11-7-18(33)13-32/h2-5,8,12,18,33H,6-7,9-11,13-15H2,1H3,(H,28,29)/t18-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223797
PNG
(US9328112, 19)
Show SMILES CN(CCO)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C25H28FN5O2/c1-29(11-12-32)22(33)15-31-9-6-16(7-10-31)24-20-14-30(2)21-4-3-17(26)13-19(21)18-5-8-27-25(28-24)23(18)20/h3-6,8,13,32H,7,9-12,14-15H2,1-2H3,(H,27,28)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223902
PNG
(US9328112, 124)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)[C@@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C28H31FN4O2/c1-32-16-23-26-21(22-15-19(29)4-7-24(22)32)8-11-30-28(26)31-27(23)18-9-12-33(13-10-18)20-5-2-17(3-6-20)14-25(34)35/h4,7-9,11,15,17,20H,2-3,5-6,10,12-14,16H2,1H3,(H,30,31)(H,34,35)/t17-,20+
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223853
PNG
(US9328112, 75)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CCC[C@@H]2CO)CC1
Show InChI InChI=1S/C27H29F2N5O2/c1-32-13-20-25-24(19-11-17(28)4-5-22(19)32)21(29)12-30-27(25)31-26(20)16-6-9-33(10-7-16)14-23(36)34-8-2-3-18(34)15-35/h4-6,11-12,18,35H,2-3,7-10,13-15H2,1H3,(H,30,31)/t18-/m1/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223919
PNG
(US9328112, 141)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C27H29FN4O2/c1-31-15-22-24-20(21-14-18(28)4-7-23(21)31)8-11-29-26(24)30-25(22)16-9-12-32(13-10-16)19-5-2-17(3-6-19)27(33)34/h4,7-9,11,14,17,19H,2-3,5-6,10,12-13,15H2,1H3,(H,29,30)(H,33,34)/t17-,19-
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223790
PNG
(US9328112, 12)
Show SMILES CN(C)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C24H26FN5O/c1-28(2)21(31)14-30-10-7-15(8-11-30)23-19-13-29(3)20-5-4-16(25)12-18(20)17-6-9-26-24(27-23)22(17)19/h4-7,9,12H,8,10-11,13-14H2,1-3H3,(H,26,27)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223851
PNG
(US9328112, 73)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CC[C@H](O)C2)CC1
Show InChI InChI=1S/C26H27F2N5O2/c1-31-13-19-24-23(18-10-16(27)2-3-21(18)31)20(28)11-29-26(24)30-25(19)15-4-7-32(8-5-15)14-22(35)33-9-6-17(34)12-33/h2-4,10-11,17,34H,5-9,12-14H2,1H3,(H,29,30)/t17-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223915
PNG
(US9328112, 137)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCN(CC(=O)N2CC(O)C2)CC1
Show InChI InChI=1S/C25H25F2N5O2/c1-30-12-18-23-16(17-8-19(26)20(27)9-21(17)30)2-5-28-25(23)29-24(18)14-3-6-31(7-4-14)13-22(34)32-10-15(33)11-32/h2-3,5,8-9,15,33H,4,6-7,10-13H2,1H3,(H,28,29)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223926
PNG
(US9328112, 148)
Show SMILES CN(C1CC(O)C1)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)c(F)cc4N(C)Cc1c23
Show InChI InChI=1S/C27H29F2N5O2/c1-32-13-20-25-18(19-11-21(28)22(29)12-23(19)32)3-6-30-27(25)31-26(20)15-4-7-34(8-5-15)14-24(36)33(2)16-9-17(35)10-16/h3-4,6,11-12,16-17,35H,5,7-10,13-14H2,1-2H3,(H,30,31)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223903
PNG
(US9328112, 125)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=C[C@@H]2COC(=O)N2CC1
Show InChI InChI=1S/C22H18F2N4O2/c1-27-9-15-19-13(14-7-16(23)17(24)8-18(14)27)2-4-25-21(19)26-20(15)11-3-5-28-12(6-11)10-30-22(28)29/h2,4,6-8,12H,3,5,9-10H2,1H3,(H,25,26)/t12-/m1/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223941
PNG
(US9328112, 163)
Show SMILES CN(C)C(=O)CN1CCC(=CC1)c1[nH]c2ncc(F)c3-c4ccccc4N(C)Cc1c23
Show InChI InChI=1S/C24H26FN5O/c1-28(2)20(31)14-30-10-8-15(9-11-30)23-17-13-29(3)19-7-5-4-6-16(19)21-18(25)12-26-24(27-23)22(17)21/h4-8,12H,9-11,13-14H2,1-3H3,(H,26,27)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223810
PNG
(US9328112, 32)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)N[C@H](C(O)=O)c1ccccc1
Show InChI InChI=1S/C29H27FN4O2/c1-34-16-23-25-21(22-15-19(30)9-12-24(22)34)13-14-31-28(25)33-26(23)18-7-10-20(11-8-18)32-27(29(35)36)17-5-3-2-4-6-17/h2-7,9,12-15,20,27,32H,8,10-11,16H2,1H3,(H,31,33)(H,35,36)/t20?,27-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223831
PNG
(US9328112, 53)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N(CCO)CCO)CC1
Show InChI InChI=1S/C26H30FN5O3/c1-30-15-21-24-19(20-14-18(27)2-3-22(20)30)4-7-28-26(24)29-25(21)17-5-8-31(9-6-17)16-23(35)32(10-12-33)11-13-34/h2-5,7,14,33-34H,6,8-13,15-16H2,1H3,(H,28,29)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223882
PNG
(US9328112, 104)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CCCC(C1)N2CC(=O)N1CCC[C@H]1CO
Show InChI InChI=1S/C30H34FN5O2/c1-34-15-25-28-23(24-14-19(31)7-8-26(24)34)9-10-32-30(28)33-29(25)18-12-20-4-2-5-21(13-18)36(20)16-27(38)35-11-3-6-22(35)17-37/h7-10,12,14,20-22,37H,2-6,11,13,15-17H2,1H3,(H,32,33)/t20?,21?,22-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223928
PNG
(US9328112, 150)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C27H28F2N4O2/c1-32-14-20-24-18(19-12-21(28)22(29)13-23(19)32)6-9-30-26(24)31-25(20)15-7-10-33(11-8-15)17-4-2-16(3-5-17)27(34)35/h6-7,9,12-13,16-17H,2-5,8,10-11,14H2,1H3,(H,30,31)(H,34,35)/t16-,17-
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223952
PNG
(US9328112, 174)
Show SMILES COC(=O)C(C)=C1CCC(CC1)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C30H33FN4O2/c1-18(30(36)37-3)19-4-7-22(8-5-19)35-14-11-20(12-15-35)28-25-17-34(2)26-9-6-21(31)16-24(26)23-10-13-32-29(33-28)27(23)25/h6,9-11,13,16,22H,4-5,7-8,12,14-15,17H2,1-3H3,(H,32,33)/b19-18-
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223904
PNG
(US9328112, 126)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=C[C@H](CO)NCC1
Show InChI InChI=1S/C21H20F2N4O/c1-27-9-15-19-13(14-7-16(22)17(23)8-18(14)27)3-5-25-21(19)26-20(15)11-2-4-24-12(6-11)10-28/h3,5-8,12,24,28H,2,4,9-10H2,1H3,(H,25,26)/t12-/m1/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223955
PNG
(US9328112, 177)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CCC(CC1)=CC(O)=O
Show InChI InChI=1S/C28H29FN4O2/c1-32-16-23-26-21(22-15-19(29)4-7-24(22)32)8-11-30-28(26)31-27(23)18-9-12-33(13-10-18)20-5-2-17(3-6-20)14-25(34)35/h4,7-9,11,14-15,20H,2-3,5-6,10,12-13,16H2,1H3,(H,30,31)(H,34,35)/b17-14-
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223911
PNG
(US9328112, 133)
Show SMILES COC(=O)CC1CC[C@@H](CC1)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)c(F)cc4N(C)Cc1c23
Show InChI InChI=1S/C29H32F2N4O2/c1-34-16-22-27-20(21-14-23(30)24(31)15-25(21)34)7-10-32-29(27)33-28(22)18-8-11-35(12-9-18)19-5-3-17(4-6-19)13-26(36)37-2/h7-8,10,14-15,17,19H,3-6,9,11-13,16H2,1-2H3,(H,32,33)/t17?,19-
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223914
PNG
(US9328112, 136)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCN(CC1)[C@@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C28H30F2N4O2/c1-33-15-21-26-19(20-13-22(29)23(30)14-24(20)33)6-9-31-28(26)32-27(21)17-7-10-34(11-8-17)18-4-2-16(3-5-18)12-25(35)36/h6-7,9,13-14,16,18H,2-5,8,10-12,15H2,1H3,(H,31,32)(H,35,36)/t16-,18+
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223946
PNG
(US9328112, 168)
Show SMILES CC[C@@H]1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCN(CC(=O)N(C)C)CC1
Show InChI InChI=1S/C26H30FN5O/c1-5-20-24-23-18(19-14-17(27)6-7-21(19)31(20)4)8-11-28-26(23)29-25(24)16-9-12-32(13-10-16)15-22(33)30(2)3/h6-9,11,14,20H,5,10,12-13,15H2,1-4H3,(H,28,29)/t20-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223813
PNG
(US9328112, 35)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C30H29FN4O2/c1-35-17-24-27-22(23-16-20(31)9-12-26(23)35)13-14-32-29(27)34-28(24)19-7-10-21(11-8-19)33-25(30(36)37)15-18-5-3-2-4-6-18/h2-7,9,12-14,16,21,25,33H,8,10-11,15,17H2,1H3,(H,32,34)(H,36,37)/t21?,25-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223794
PNG
(US9328112, 16)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(O)=O)CC1
Show InChI InChI=1S/C22H21FN4O2/c1-26-11-17-20-15(16-10-14(23)2-3-18(16)26)4-7-24-22(20)25-21(17)13-5-8-27(9-6-13)12-19(28)29/h2-5,7,10H,6,8-9,11-12H2,1H3,(H,24,25)(H,28,29)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223842
PNG
(US9328112, 64)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CCC[C@@H]2CO)CC1
Show InChI InChI=1S/C27H30FN5O2/c1-31-14-22-25-20(21-13-18(28)4-5-23(21)31)6-9-29-27(25)30-26(22)17-7-11-32(12-8-17)15-24(35)33-10-2-3-19(33)16-34/h4-7,9,13,19,34H,2-3,8,10-12,14-16H2,1H3,(H,29,30)/t19-/m1/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223783
PNG
(US9328112, 5)
Show SMILES CS(=O)(=O)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4NCc1c23
Show InChI InChI=1S/C20H19FN4O2S/c1-28(26,27)25-8-5-12(6-9-25)19-16-11-23-17-3-2-13(21)10-15(17)14-4-7-22-20(24-19)18(14)16/h2-5,7,10,23H,6,8-9,11H2,1H3,(H,22,24)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223856
PNG
(US9328112, 78)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CN(CC2C1)S(C)(=O)=O
Show InChI InChI=1S/C23H23FN4O2S/c1-27-12-19-21-17(18-9-16(24)3-4-20(18)27)5-6-25-23(21)26-22(19)13-7-14-10-28(31(2,29)30)11-15(14)8-13/h3-7,9,14-15H,8,10-12H2,1-2H3,(H,25,26)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223959
PNG
(US9328112, 181)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4ccccc14)c23)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C27H29FN4O2/c1-31-15-20-24-23(19-4-2-3-5-22(19)31)21(28)14-29-26(24)30-25(20)16-10-12-32(13-11-16)18-8-6-17(7-9-18)27(33)34/h2-5,10,14,17-18H,6-9,11-13,15H2,1H3,(H,29,30)(H,33,34)/t17-,18-
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223832
PNG
(US9328112, 54)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CC(F)(F)C2)CC1
Show InChI InChI=1S/C25H24F3N5O/c1-31-11-19-22-17(18-10-16(26)2-3-20(18)31)4-7-29-24(22)30-23(19)15-5-8-32(9-6-15)12-21(34)33-13-25(27,28)14-33/h2-5,7,10H,6,8-9,11-14H2,1H3,(H,29,30)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223830
PNG
(US9328112, 52)
Show SMILES CNC(=O)C1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C23H23FN4O/c1-25-23(29)14-5-3-13(4-6-14)21-18-12-28(2)19-8-7-15(24)11-17(19)16-9-10-26-22(27-21)20(16)18/h3,7-11,14H,4-6,12H2,1-2H3,(H,25,29)(H,26,27)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223913
PNG
(US9328112, 135)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cccnc14)c23)C1=CCNCC1
Show InChI InChI=1S/C19H19N5/c1-24-11-15-16-13(14-3-2-7-22-19(14)24)6-10-21-18(16)23-17(15)12-4-8-20-9-5-12/h2-4,6-7,10,20H,5,8-9,11H2,1H3,(H,21,23)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223814
PNG
(US9328112, 36)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)N[C@H](C(O)=O)C(C)(C)C
Show InChI InChI=1S/C27H31FN4O2/c1-27(2,3)24(26(33)34)30-17-8-5-15(6-9-17)23-20-14-32(4)21-10-7-16(28)13-19(21)18-11-12-29-25(31-23)22(18)20/h5,7,10-13,17,24,30H,6,8-9,14H2,1-4H3,(H,29,31)(H,33,34)/t17?,24-/m1/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223964
PNG
(US9328112, 186)
Show SMILES CC[C@@H]1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCN(CC1)[C@H]1C[C@H](C1)C(=O)OC
Show InChI InChI=1S/C28H31FN4O2/c1-4-22-25-24-20(21-15-18(29)5-6-23(21)32(22)2)7-10-30-27(24)31-26(25)16-8-11-33(12-9-16)19-13-17(14-19)28(34)35-3/h5-8,10,15,17,19,22H,4,9,11-14H2,1-3H3,(H,30,31)/t17-,19+,22-/m0/s1
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223908
PNG
(US9328112, 130)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C28H31FN4O2/c1-32-16-23-26-21(22-15-19(29)4-7-24(22)32)8-11-30-28(26)31-27(23)18-9-12-33(13-10-18)20-5-2-17(3-6-20)14-25(34)35/h4,7-9,11,15,17,20H,2-3,5-6,10,12-14,16H2,1H3,(H,30,31)(H,34,35)/t17-,20-
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223884
PNG
(US9328112, 106)
Show SMILES CN(C1CC(O)C1)C(=O)CN1C2CCCC1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C30H34FN5O2/c1-34-15-25-28-23(24-12-18(31)6-7-26(24)34)8-9-32-30(28)33-29(25)17-10-19-4-3-5-20(11-17)36(19)16-27(38)35(2)21-13-22(37)14-21/h6-10,12,19-22,37H,3-5,11,13-16H2,1-2H3,(H,32,33)
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223931
PNG
(US9328112, 153)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN2[C@@H](COC2=O)C1
Show InChI InChI=1S/C22H19FN4O2/c1-26-10-17-19-15(16-9-13(23)2-3-18(16)26)4-6-24-21(19)25-20(17)12-5-7-27-14(8-12)11-29-22(27)28/h2-6,9,14H,7-8,10-11H2,1H3,(H,24,25)/t14-/m1/s1
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223821
PNG
(US9328112, 43)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H18FN3O2S/c1-26-12-18-20-16(17-11-14(23)5-8-19(17)26)9-10-24-22(20)25-21(18)13-3-6-15(7-4-13)29(2,27)28/h3-11H,12H2,1-2H3,(H,24,25)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223945
PNG
(US9328112, 167)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C28H30F2N4O2/c1-33-15-21-26-25(20-13-18(29)4-7-23(20)33)22(30)14-31-28(26)32-27(21)17-8-10-34(11-9-17)19-5-2-16(3-6-19)12-24(35)36/h4,7-8,13-14,16,19H,2-3,5-6,9-12,15H2,1H3,(H,31,32)(H,35,36)/t16-,19-
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223907
PNG
(US9328112, 129)
Show SMILES CN(C)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)CCc1c23
Show InChI InChI=1S/C25H28FN5O/c1-29(2)22(32)15-31-12-7-16(8-13-31)24-19-9-11-30(3)21-5-4-17(26)14-20(21)18-6-10-27-25(28-24)23(18)19/h4-7,10,14H,8-9,11-13,15H2,1-3H3,(H,27,28)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223859
PNG
(US9328112, 81)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C23H18FN3O2/c1-27-12-18-21-16(17-11-15(24)6-7-19(17)27)8-9-25-23(21)26-22(18)14-4-2-13(3-5-14)10-20(28)29/h2-9,11H,10,12H2,1H3,(H,25,26)(H,28,29)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223916
PNG
(US9328112, 138)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cccnc14)c23)C1=CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C20H21N5O2S/c1-24-12-16-17-14(15-4-3-8-22-20(15)24)5-9-21-19(17)23-18(16)13-6-10-25(11-7-13)28(2,26)27/h3-6,8-9H,7,10-12H2,1-2H3,(H,21,23)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223795
PNG
(US9328112, 17)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CCC[C@H]2CO)CC1
Show InChI InChI=1S/C27H30FN5O2/c1-31-14-22-25-20(21-13-18(28)4-5-23(21)31)6-9-29-27(25)30-26(22)17-7-11-32(12-8-17)15-24(35)33-10-2-3-19(33)16-34/h4-7,9,13,19,34H,2-3,8,10-12,14-16H2,1H3,(H,29,30)/t19-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223960
PNG
(US9328112, 182)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4ccccc14)c23)C1=CCN(CC1)[C@@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C28H31FN4O2/c1-32-16-21-26-25(20-4-2-3-5-23(20)32)22(29)15-30-28(26)31-27(21)18-10-12-33(13-11-18)19-8-6-17(7-9-19)14-24(34)35/h2-5,10,15,17,19H,6-9,11-14,16H2,1H3,(H,30,31)(H,34,35)/t17-,19+
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223857
PNG
(US9328112, 79)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@H]2CC[C@@H](C1)N2CC(=O)N1CCC[C@H]1CO
Show InChI InChI=1S/C29H32FN5O2/c1-33-14-24-27-22(23-13-18(30)4-7-25(23)33)8-9-31-29(27)32-28(24)17-11-19-5-6-20(12-17)35(19)15-26(37)34-10-2-3-21(34)16-36/h4,7-9,11,13,19-21,36H,2-3,5-6,10,12,14-16H2,1H3,(H,31,32)/t19-,20+,21+/m1/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223958
PNG
(US9328112, 180)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4ccccc14)c23)C1=CCN(CC1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C28H31FN4O2/c1-32-16-21-26-25(20-4-2-3-5-23(20)32)22(29)15-30-28(26)31-27(21)18-10-12-33(13-11-18)19-8-6-17(7-9-19)14-24(34)35/h2-5,10,15,17,19H,6-9,11-14,16H2,1H3,(H,30,31)(H,34,35)/t17-,19-
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223876
PNG
(US9328112, 98)
Show SMILES CN(C1CC(O)C1)C(=O)CN1[C@H]2CC[C@@H]1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C29H32FN5O2/c1-33-14-24-27-22(23-11-17(30)3-6-25(23)33)7-8-31-29(27)32-28(24)16-9-18-4-5-19(10-16)35(18)15-26(37)34(2)20-12-21(36)13-20/h3,6-9,11,18-21,36H,4-5,10,12-15H2,1-2H3,(H,31,32)/t18-,19+,20?,21?/m1/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223944
PNG
(US9328112, 166)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C27H28F2N4O2/c1-32-14-20-24-23(19-12-17(28)4-7-22(19)32)21(29)13-30-26(24)31-25(20)15-8-10-33(11-9-15)18-5-2-16(3-6-18)27(34)35/h4,7-8,12-13,16,18H,2-3,5-6,9-11,14H2,1H3,(H,30,31)(H,34,35)/t16-,18-
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223838
PNG
(US9328112, 60)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1cccnc1
Show InChI InChI=1S/C20H15FN4/c1-25-11-16-18-14(15-9-13(21)4-5-17(15)25)6-8-23-20(18)24-19(16)12-3-2-7-22-10-12/h2-10H,11H2,1H3,(H,23,24)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223971
PNG
(US9328112, 193)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CC(C1)C(O)=O
Show InChI InChI=1S/C25H24F2N4O2/c1-30-12-18-22-21(17-10-15(26)2-3-20(17)30)19(27)11-28-24(22)29-23(18)13-4-6-31(7-5-13)16-8-14(9-16)25(32)33/h2-4,10-11,14,16H,5-9,12H2,1H3,(H,28,29)(H,32,33)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223906
PNG
(US9328112, 128)
Show SMILES CN1CCc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C22H23FN4O2S/c1-26-10-8-17-20-16(18-13-15(23)3-4-19(18)26)5-9-24-22(20)25-21(17)14-6-11-27(12-7-14)30(2,28)29/h3-6,9,13H,7-8,10-12H2,1-2H3,(H,24,25)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223850
PNG
(US9328112, 72)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CC(O)C2)CC1
Show InChI InChI=1S/C25H25F2N5O2/c1-30-12-18-23-22(17-8-15(26)2-3-20(17)30)19(27)9-28-25(23)29-24(18)14-4-6-31(7-5-14)13-21(34)32-10-16(33)11-32/h2-4,8-9,16,33H,5-7,10-13H2,1H3,(H,28,29)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223970
PNG
(US9328112, 192)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CC(CC(O)=O)C1
Show InChI InChI=1S/C26H26F2N4O2/c1-31-13-19-24-23(18-11-16(27)2-3-21(18)31)20(28)12-29-26(24)30-25(19)15-4-6-32(7-5-15)17-8-14(9-17)10-22(33)34/h2-4,11-12,14,17H,5-10,13H2,1H3,(H,29,30)(H,33,34)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223961
PNG
(US9328112, 183)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4ccccc14)c23)C1=CCN(CC1)[C@H]1CC[C@H](CC1)C(O)=O
Show InChI InChI=1S/C27H29FN4O2/c1-31-15-20-24-23(19-4-2-3-5-22(19)31)21(28)14-29-26(24)30-25(20)16-10-12-32(13-11-16)18-8-6-17(7-9-18)27(33)34/h2-5,10,14,17-18H,6-9,11-13,15H2,1H3,(H,29,30)(H,33,34)/t17-,18+
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223847
PNG
(US9328112, 69)
Show SMILES COCCS(=O)(=O)N1CC2CC(=CC2C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C25H27FN4O3S/c1-29-14-21-23-19(20-11-18(26)3-4-22(20)29)5-6-27-25(23)28-24(21)15-9-16-12-30(13-17(16)10-15)34(31,32)8-7-33-2/h3-6,9,11,16-17H,7-8,10,12-14H2,1-2H3,(H,27,28)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223818
PNG
(US9328112, 40)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C30H29FN4O3/c1-35-16-24-27-22(23-15-19(31)6-11-26(23)35)12-13-32-29(27)34-28(24)18-4-7-20(8-5-18)33-25(30(37)38)14-17-2-9-21(36)10-3-17/h2-4,6,9-13,15,20,25,33,36H,5,7-8,14,16H2,1H3,(H,32,34)(H,37,38)/t20?,25-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223924
PNG
(US9328112, 146)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)c(F)cc14)c23)C1=CCN(CC1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C28H30F2N4O2/c1-33-15-21-26-19(20-13-22(29)23(30)14-24(20)33)6-9-31-28(26)32-27(21)17-7-10-34(11-8-17)18-4-2-16(3-5-18)12-25(35)36/h6-7,9,13-14,16,18H,2-5,8,10-12,15H2,1H3,(H,31,32)(H,35,36)/t16-,18-
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223878
PNG
(US9328112, 100)
Show SMILES CNC(=O)N1C2CCCC1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C25H26FN5O/c1-27-25(32)31-16-4-3-5-17(31)11-14(10-16)23-20-13-30(2)21-7-6-15(26)12-19(21)18-8-9-28-24(29-23)22(18)20/h6-10,12,16-17H,3-5,11,13H2,1-2H3,(H,27,32)(H,28,29)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223954
PNG
(US9328112, 176)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CCC(CC1)=C(C)C(O)=O
Show InChI InChI=1S/C29H31FN4O2/c1-17(29(35)36)18-3-6-21(7-4-18)34-13-10-19(11-14-34)27-24-16-33(2)25-8-5-20(30)15-23(25)22-9-12-31-28(32-27)26(22)24/h5,8-10,12,15,21H,3-4,6-7,11,13-14,16H2,1-2H3,(H,31,32)(H,35,36)/b18-17-
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223938
PNG
(US9328112, 160)
Show SMILES CN1Cc2c([nH]c3nccc(-c4ccccc14)c23)C1=CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C21H22N4O2S/c1-24-13-17-19-16(15-5-3-4-6-18(15)24)7-10-22-21(19)23-20(17)14-8-11-25(12-9-14)28(2,26)27/h3-8,10H,9,11-13H2,1-2H3,(H,22,23)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223809
PNG
(US9328112, 31)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)NCC(O)=O
Show InChI InChI=1S/C23H23FN4O2/c1-28-12-18-21-16(17-10-14(24)4-7-19(17)28)8-9-25-23(21)27-22(18)13-2-5-15(6-3-13)26-11-20(29)30/h2,4,7-10,15,26H,3,5-6,11-12H2,1H3,(H,25,27)(H,29,30)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


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More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223881
PNG
(US9328112, 103)
Show SMILES CN(CCO)C(=O)CN1C2CCCC1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C28H32FN5O2/c1-32(10-11-35)25(36)16-34-19-4-3-5-20(34)13-17(12-19)27-23-15-33(2)24-7-6-18(29)14-22(24)21-8-9-30-28(31-27)26(21)23/h6-9,12,14,19-20,35H,3-5,10-11,13,15-16H2,1-2H3,(H,30,31)
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AbbVie Inc.

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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


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More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223848
PNG
(US9328112, 70)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CCC[C@H]2CO)CC1
Show InChI InChI=1S/C27H29F2N5O2/c1-32-13-20-25-24(19-11-17(28)4-5-22(19)32)21(29)12-30-27(25)31-26(20)16-6-9-33(10-7-16)14-23(36)34-8-2-3-18(34)15-35/h4-6,11-12,18,35H,2-3,7-10,13-15H2,1H3,(H,30,31)/t18-/m0/s1
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223969
PNG
(US9328112, 191)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CCC(CC1)C(C#N)C(O)=O
Show InChI InChI=1S/C29H30FN5O2/c1-34-16-24-26-21(22-14-19(30)4-7-25(22)34)8-11-32-28(26)33-27(24)18-9-12-35(13-10-18)20-5-2-17(3-6-20)23(15-31)29(36)37/h4,7-9,11,14,17,20,23H,2-3,5-6,10,12-13,16H2,1H3,(H,32,33)(H,36,37)
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223837
PNG
(US9328112, 59)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CNCC2C1
Show InChI InChI=1S/C22H21FN4/c1-27-11-18-20-16(17-8-15(23)2-3-19(17)27)4-5-25-22(20)26-21(18)12-6-13-9-24-10-14(13)7-12/h2-6,8,13-14,24H,7,9-11H2,1H3,(H,25,26)
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AbbVie Inc.

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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223852
PNG
(US9328112, 74)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CC(CO)C2)CC1
Show InChI InChI=1S/C26H27F2N5O2/c1-31-12-19-24-23(18-8-17(27)2-3-21(18)31)20(28)9-29-26(24)30-25(19)16-4-6-32(7-5-16)13-22(35)33-10-15(11-33)14-34/h2-4,8-9,15,34H,5-7,10-14H2,1H3,(H,29,30)
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223865
PNG
(US9328112, 87)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCNCC1
Show InChI InChI=1S/C21H21FN4/c1-26-12-17-19-15(16-11-14(22)4-5-18(16)26)7-10-24-21(19)25-20(17)13-3-2-8-23-9-6-13/h3-5,7,10-11,23H,2,6,8-9,12H2,1H3,(H,24,25)
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AbbVie Inc.

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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223947
PNG
(US9328112, 169)
Show SMILES CN1Cc2c([nH]c3nccc(-c4ccccc14)c23)C1=CCN(CC1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C28H32N4O2/c1-31-17-23-26-22(21-4-2-3-5-24(21)31)10-13-29-28(26)30-27(23)19-11-14-32(15-12-19)20-8-6-18(7-9-20)16-25(33)34/h2-5,10-11,13,18,20H,6-9,12,14-17H2,1H3,(H,29,30)(H,33,34)/t18-,20-
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223816
PNG
(US9328112, 38)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C24H25FN4O3/c1-29-11-18-21-16(17-10-14(25)4-7-20(17)29)8-9-26-23(21)28-22(18)13-2-5-15(6-3-13)27-19(12-30)24(31)32/h2,4,7-10,15,19,27,30H,3,5-6,11-12H2,1H3,(H,26,28)(H,31,32)/t15?,19-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223805
PNG
(US9328112, 27)
Show SMILES CN(CCO)C(=O)CN1CCC(CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C25H30FN5O2/c1-29(11-12-32)22(33)15-31-9-6-16(7-10-31)24-20-14-30(2)21-4-3-17(26)13-19(21)18-5-8-27-25(28-24)23(18)20/h3-5,8,13,16,32H,6-7,9-12,14-15H2,1-2H3,(H,27,28)
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223804
PNG
(US9328112, 26)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1CCN(CC(=O)N2CCC[C@H]2CO)CC1
Show InChI InChI=1S/C27H32FN5O2/c1-31-14-22-25-20(21-13-18(28)4-5-23(21)31)6-9-29-27(25)30-26(22)17-7-11-32(12-8-17)15-24(35)33-10-2-3-19(33)16-34/h4-6,9,13,17,19,34H,2-3,7-8,10-12,14-16H2,1H3,(H,29,30)/t19-/m0/s1
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223793
PNG
(US9328112, 15)
Show SMILES CS(=O)(=O)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4OCc1c23
Show InChI InChI=1S/C20H18FN3O3S/c1-28(25,26)24-8-5-12(6-9-24)19-16-11-27-17-3-2-13(21)10-15(17)14-4-7-22-20(23-19)18(14)16/h2-5,7,10H,6,8-9,11H2,1H3,(H,22,23)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223862
PNG
(US9328112, 84)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CN(CC(=O)N3CC(O)C3)CC2C1
Show InChI InChI=1S/C27H28FN5O2/c1-31-13-22-25-20(21-8-18(28)2-3-23(21)31)4-5-29-27(25)30-26(22)15-6-16-9-32(10-17(16)7-15)14-24(35)33-11-19(34)12-33/h2-6,8,16-17,19,34H,7,9-14H2,1H3,(H,29,30)
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223917
PNG
(US9328112, 139)
Show SMILES CNC(=O)N1CCC(=CC1)c1[nH]c2nccc3-c4cccnc4N(C)Cc1c23
Show InChI InChI=1S/C21H22N6O/c1-22-21(28)27-10-6-13(7-11-27)18-16-12-26(2)20-15(4-3-8-24-20)14-5-9-23-19(25-18)17(14)16/h3-6,8-9H,7,10-12H2,1-2H3,(H,22,28)(H,23,25)
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223936
PNG
(US9328112, 158)
Show SMILES CN1Cc2c([nH]c3nccc(-c4ccccc14)c23)C1=CCNCC1
Show InChI InChI=1S/C20H20N4/c1-24-12-16-18-15(14-4-2-3-5-17(14)24)8-11-22-20(18)23-19(16)13-6-9-21-10-7-13/h2-6,8,11,21H,7,9-10,12H2,1H3,(H,22,23)
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223834
PNG
(US9328112, 56)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@H]2CC[C@@H](C1)N2S(C)(=O)=O
Show InChI InChI=1S/C23H23FN4O2S/c1-27-12-19-21-17(18-11-14(24)3-6-20(18)27)7-8-25-23(21)26-22(19)13-9-15-4-5-16(10-13)28(15)31(2,29)30/h3,6-9,11,15-16H,4-5,10,12H2,1-2H3,(H,25,26)/t15-,16+/m1/s1
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223858
PNG
(US9328112, 80)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@H]2CC[C@@H](C1)N2CC(=O)N1CC(O)C1
Show InChI InChI=1S/C27H28FN5O2/c1-31-13-22-25-20(21-10-16(28)2-5-23(21)31)6-7-29-27(25)30-26(22)15-8-17-3-4-18(9-15)33(17)14-24(35)32-11-19(34)12-32/h2,5-8,10,17-19,34H,3-4,9,11-14H2,1H3,(H,29,30)/t17-,18+/m1/s1
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223883
PNG
(US9328112, 105)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CCCC(C1)N2CC(=O)N1CC(O)C1
Show InChI InChI=1S/C28H30FN5O2/c1-32-14-23-26-21(22-11-17(29)5-6-24(22)32)7-8-30-28(26)31-27(23)16-9-18-3-2-4-19(10-16)34(18)15-25(36)33-12-20(35)13-33/h5-9,11,18-20,35H,2-4,10,12-15H2,1H3,(H,30,31)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223863
PNG
(US9328112, 85)
Show SMILES CN(CC(O)CO)C(=O)CN1CC2CC(=CC2C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C28H32FN5O3/c1-32-13-23-26-21(22-9-19(29)3-4-24(22)32)5-6-30-28(26)31-27(23)16-7-17-10-34(11-18(17)8-16)14-25(37)33(2)12-20(36)15-35/h3-7,9,17-18,20,35-36H,8,10-15H2,1-2H3,(H,30,31)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223860
PNG
(US9328112, 82)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1cccc(CC(O)=O)c1
Show InChI InChI=1S/C23H18FN3O2/c1-27-12-18-21-16(17-11-15(24)5-6-19(17)27)7-8-25-23(21)26-22(18)14-4-2-3-13(9-14)10-20(28)29/h2-9,11H,10,12H2,1H3,(H,25,26)(H,28,29)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223843
PNG
(US9328112, 65)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)OC(C)(C)C)CC1
Show InChI InChI=1S/C26H28F2N4O2/c1-26(2,3)34-21(33)14-32-9-7-15(8-10-32)24-18-13-31(4)20-6-5-16(27)11-17(20)22-19(28)12-29-25(30-24)23(18)22/h5-7,11-12H,8-10,13-14H2,1-4H3,(H,29,30)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223849
PNG
(US9328112, 71)
Show SMILES CN(CCO)C(=O)CN1CCC(=CC1)c1[nH]c2ncc(F)c3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C25H27F2N5O2/c1-30(9-10-33)21(34)14-32-7-5-15(6-8-32)24-18-13-31(2)20-4-3-16(26)11-17(20)22-19(27)12-28-25(29-24)23(18)22/h3-5,11-12,33H,6-10,13-14H2,1-2H3,(H,28,29)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223808
PNG
(US9328112, 30)
Show SMILES C[C@H](NC1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23)C(O)=O
Show InChI InChI=1S/C24H25FN4O2/c1-13(24(30)31)27-16-6-3-14(4-7-16)22-19-12-29(2)20-8-5-15(25)11-18(20)17-9-10-26-23(28-22)21(17)19/h3,5,8-11,13,16,27H,4,6-7,12H2,1-2H3,(H,26,28)(H,30,31)/t13-,16?/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223872
PNG
(US9328112, 94)
Show SMILES CN(C1CC(O)C1)C(=O)CN1CC2CC(=CC2C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C29H32FN5O2/c1-33-14-24-27-22(23-9-19(30)3-4-25(23)33)5-6-31-29(27)32-28(24)16-7-17-12-35(13-18(17)8-16)15-26(37)34(2)20-10-21(36)11-20/h3-7,9,17-18,20-21,36H,8,10-15H2,1-2H3,(H,31,32)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223823
PNG
(US9328112, 45)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1ccc(nc1)S(C)(=O)=O
Show InChI InChI=1S/C21H17FN4O2S/c1-26-11-16-19-14(15-9-13(22)4-5-17(15)26)7-8-23-21(19)25-20(16)12-3-6-18(24-10-12)29(2,27)28/h3-10H,11H2,1-2H3,(H,23,25)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223829
PNG
(US9328112, 51)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)C(=O)N1CC(O)C1
Show InChI InChI=1S/C25H25FN4O2/c1-29-13-20-22-18(19-10-16(26)6-7-21(19)29)8-9-27-24(22)28-23(20)14-2-4-15(5-3-14)25(32)30-11-17(31)12-30/h2,6-10,15,17,31H,3-5,11-13H2,1H3,(H,27,28)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223798
PNG
(US9328112, 20)
Show SMILES CC1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C22H23FN4O2S/c1-13-19-20-16(17-12-15(23)4-5-18(17)26(13)2)6-9-24-22(20)25-21(19)14-7-10-27(11-8-14)30(3,28)29/h4-7,9,12-13H,8,10-11H2,1-3H3,(H,24,25)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223965
PNG
(US9328112, 187)
Show SMILES CC[C@@H]1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCN(CC1)[C@H]1C[C@H](C1)C(O)=O
Show InChI InChI=1S/C27H29FN4O2/c1-3-21-24-23-19(20-14-17(28)4-5-22(20)31(21)2)6-9-29-26(23)30-25(24)15-7-10-32(11-8-15)18-12-16(13-18)27(33)34/h4-7,9,14,16,18,21H,3,8,10-13H2,1-2H3,(H,29,30)(H,33,34)/t16-,18+,21-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223967
PNG
(US9328112, 189)
Show SMILES CC[C@@H]1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCN(CC1)[C@H]1C[C@@H](C1)C(O)=O
Show InChI InChI=1S/C27H29FN4O2/c1-3-21-24-23-19(20-14-17(28)4-5-22(20)31(21)2)6-9-29-26(23)30-25(24)15-7-10-32(11-8-15)18-12-16(13-18)27(33)34/h4-7,9,14,16,18,21H,3,8,10-13H2,1-2H3,(H,29,30)(H,33,34)/t16-,18-,21-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223948
PNG
(US9328112, 170)
Show SMILES CN1Cc2c([nH]c3nccc(-c4ccccc14)c23)C1=CCN(CC1)[C@@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C28H32N4O2/c1-31-17-23-26-22(21-4-2-3-5-24(21)31)10-13-29-28(26)30-27(23)19-11-14-32(15-12-19)20-8-6-18(7-9-20)16-25(33)34/h2-5,10-11,13,18,20H,6-9,12,14-17H2,1H3,(H,29,30)(H,33,34)/t18-,20+
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223886
PNG
(US9328112, 108)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CCCC(C1)N2CC(O)=O
Show InChI InChI=1S/C25H25FN4O2/c1-29-12-20-23-18(19-11-15(26)5-6-21(19)29)7-8-27-25(23)28-24(20)14-9-16-3-2-4-17(10-14)30(16)13-22(31)32/h5-9,11,16-17H,2-4,10,12-13H2,1H3,(H,27,28)(H,31,32)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223885
PNG
(US9328112, 107)
Show SMILES CN(CC(O)CO)C(=O)CN1C2CCCC1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C29H34FN5O3/c1-33-14-24-27-22(23-12-18(30)6-7-25(23)33)8-9-31-29(27)32-28(24)17-10-19-4-3-5-20(11-17)35(19)15-26(38)34(2)13-21(37)16-36/h6-10,12,19-21,36-37H,3-5,11,13-16H2,1-2H3,(H,31,32)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223927
PNG
(US9328112, 149)
Show SMILES CN(C)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cccnc4N(C)Cc1c23
Show InChI InChI=1S/C23H26N6O/c1-27(2)19(30)14-29-11-7-15(8-12-29)21-18-13-28(3)23-17(5-4-9-25-23)16-6-10-24-22(26-21)20(16)18/h4-7,9-10H,8,11-14H2,1-3H3,(H,24,26)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223879
PNG
(US9328112, 101)
Show SMILES CN(C)C(=O)CN1C2CCCC1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C27H30FN5O/c1-31(2)24(34)15-33-18-5-4-6-19(33)12-16(11-18)26-22-14-32(3)23-8-7-17(28)13-21(23)20-9-10-29-27(30-26)25(20)22/h7-11,13,18-19H,4-6,12,14-15H2,1-3H3,(H,29,30)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223940
PNG
(US9328112, 162)
Show SMILES CN(C)C(=O)CN1CCC(=CC1)c1[nH]c2nccc3-c4ccccc4N(C)Cc1c23
Show InChI InChI=1S/C24H27N5O/c1-27(2)21(30)15-29-12-9-16(10-13-29)23-19-14-28(3)20-7-5-4-6-17(20)18-8-11-25-24(26-23)22(18)19/h4-9,11H,10,12-15H2,1-3H3,(H,25,26)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223953
PNG
(US9328112, 175)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CCC(CC1)=CC(=O)OC(C)(C)C
Show InChI InChI=1S/C32H37FN4O2/c1-32(2,3)39-28(38)17-20-5-8-23(9-6-20)37-15-12-21(13-16-37)30-26-19-36(4)27-10-7-22(33)18-25(27)24-11-14-34-31(35-30)29(24)26/h7,10-12,14,17-18,23H,5-6,8-9,13,15-16,19H2,1-4H3,(H,34,35)/b20-17-
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223950
PNG
(US9328112, 172)
Show SMILES CN1Cc2c([nH]c3nccc(-c4ccccc14)c23)C1=CCN(CC1)C1CCC(CC1)C(O)=O
Show InChI InChI=1S/C27H30N4O2/c1-30-16-22-24-21(20-4-2-3-5-23(20)30)10-13-28-26(24)29-25(22)17-11-14-31(15-12-17)19-8-6-18(7-9-19)27(32)33/h2-5,10-11,13,18-19H,6-9,12,14-16H2,1H3,(H,28,29)(H,32,33)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223828
PNG
(US9328112, 50)
Show SMILES CN(C)C(=O)C1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C24H25FN4O/c1-28(2)24(30)15-6-4-14(5-7-15)22-19-13-29(3)20-9-8-16(25)12-18(20)17-10-11-26-23(27-22)21(17)19/h4,8-12,15H,5-7,13H2,1-3H3,(H,26,27)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223789
PNG
(US9328112, 11)
Show SMILES CCC1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H25FN4O2S/c1-4-18-21-20-16(17-13-15(24)5-6-19(17)27(18)2)7-10-25-23(20)26-22(21)14-8-11-28(12-9-14)31(3,29)30/h5-8,10,13,18H,4,9,11-12H2,1-3H3,(H,25,26)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223812
PNG
(US9328112, 34)
Show SMILES CC(C)[C@H](NC1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23)C(O)=O
Show InChI InChI=1S/C26H29FN4O2/c1-14(2)23(26(32)33)29-17-7-4-15(5-8-17)24-20-13-31(3)21-9-6-16(27)12-19(21)18-10-11-28-25(30-24)22(18)20/h4,6,9-12,14,17,23,29H,5,7-8,13H2,1-3H3,(H,28,30)(H,32,33)/t17?,23-/m0/s1
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223867
PNG
(US9328112, 89)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C22H23FN4O2S/c1-26-13-18-20-16(17-12-15(23)5-6-19(17)26)7-9-24-22(20)25-21(18)14-4-3-10-27(11-8-14)30(2,28)29/h4-7,9,12H,3,8,10-11,13H2,1-2H3,(H,24,25)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223942
PNG
(US9328112, 164)
Show SMILES OCC(O)CN1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4OCc1c23
Show InChI InChI=1S/C22H22FN3O3/c23-14-1-2-19-17(9-14)16-3-6-24-22-20(16)18(12-29-19)21(25-22)13-4-7-26(8-5-13)10-15(28)11-27/h1-4,6,9,15,27-28H,5,7-8,10-12H2,(H,24,25)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223963
PNG
(US9328112, 185)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C1CCC(CC1)C(C)(C)C(O)=O
Show InChI InChI=1S/C30H35FN4O2/c1-30(2,29(36)37)19-4-7-21(8-5-19)35-14-11-18(12-15-35)27-24-17-34(3)25-9-6-20(31)16-23(25)22-10-13-32-28(33-27)26(22)24/h6,9-11,13,16,19,21H,4-5,7-8,12,14-15,17H2,1-3H3,(H,32,33)(H,36,37)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223873
PNG
(US9328112, 95)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(C1)S(C)(=O)=O
Show InChI InChI=1S/C21H21FN4O2S/c1-25-12-17-19-15(16-10-14(22)5-6-18(16)25)7-8-23-21(19)24-20(17)13-4-3-9-26(11-13)29(2,27)28/h4-8,10H,3,9,11-12H2,1-2H3,(H,23,24)
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AbbVie Inc.

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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223817
PNG
(US9328112, 39)
Show SMILES CCC[C@H](NC1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23)C(O)=O
Show InChI InChI=1S/C26H29FN4O2/c1-3-4-21(26(32)33)29-17-8-5-15(6-9-17)24-20-14-31(2)22-10-7-16(27)13-19(22)18-11-12-28-25(30-24)23(18)20/h5,7,10-13,17,21,29H,3-4,6,8-9,14H2,1-2H3,(H,28,30)(H,32,33)/t17?,21-/m0/s1
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223962
PNG
(US9328112, 184)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(CC1)C1CCC(CC1)=CC(O)=O
Show InChI InChI=1S/C29H31FN4O2/c1-33-17-24-27-22(23-16-20(30)6-9-25(23)33)10-12-31-29(27)32-28(24)19-3-2-13-34(14-11-19)21-7-4-18(5-8-21)15-26(35)36/h3,6,9-10,12,15-16,21H,2,4-5,7-8,11,13-14,17H2,1H3,(H,31,32)(H,35,36)/b18-15-
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223822
PNG
(US9328112, 44)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1ccncc1
Show InChI InChI=1S/C20H15FN4/c1-25-11-16-18-14(15-10-13(21)2-3-17(15)25)6-9-23-20(18)24-19(16)12-4-7-22-8-5-12/h2-10H,11H2,1H3,(H,23,24)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223861
PNG
(US9328112, 83)
Show SMILES CN(CC(O)CO)C(=O)CN1[C@H]2CC[C@@H]1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C28H32FN5O3/c1-32-13-23-26-21(22-11-17(29)3-6-24(22)32)7-8-30-28(26)31-27(23)16-9-18-4-5-19(10-16)34(18)14-25(37)33(2)12-20(36)15-35/h3,6-9,11,18-20,35-36H,4-5,10,12-15H2,1-2H3,(H,30,31)/t18-,19+,20?/m1/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223949
PNG
(US9328112, 171)
Show SMILES CN1Cc2c([nH]c3nccc(-c4ccccc14)c23)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C27H30N4O2/c1-30-16-22-24-21(20-4-2-3-5-23(20)30)10-13-28-26(24)29-25(22)17-11-14-31(15-12-17)19-8-6-18(7-9-19)27(32)33/h2-5,10-11,13,18-19H,6-9,12,14-16H2,1H3,(H,28,29)(H,32,33)/t18-,19-
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223966
PNG
(US9328112, 188)
Show SMILES CN1CCc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)[C@H]1C[C@H](C1)C(O)=O
Show InChI InChI=1S/C26H27FN4O2/c1-30-9-7-20-23-19(21-14-17(27)2-3-22(21)30)4-8-28-25(23)29-24(20)15-5-10-31(11-6-15)18-12-16(13-18)26(32)33/h2-5,8,14,16,18H,6-7,9-13H2,1H3,(H,28,29)(H,32,33)/t16-,18+
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223806
PNG
(US9328112, 28)
Show SMILES CCOC(=O)C1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCNCC1
Show InChI InChI=1S/C23H23FN4O2/c1-3-30-23(29)21-19-18-15(16-12-14(24)4-5-17(16)28(21)2)8-11-26-22(18)27-20(19)13-6-9-25-10-7-13/h4-6,8,11-12,21,25H,3,7,9-10H2,1-2H3,(H,26,27)
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223825
PNG
(US9328112, 47)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H16FN3O2/c1-26-11-17-19-15(16-10-14(23)6-7-18(16)26)8-9-24-21(19)25-20(17)12-2-4-13(5-3-12)22(27)28/h2-10H,11H2,1H3,(H,24,25)(H,27,28)
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223866
PNG
(US9328112, 88)
Show SMILES CN(C)C(=O)CN1CCC=C(CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C25H28FN5O/c1-29(2)22(32)15-31-11-4-5-16(9-12-31)24-20-14-30(3)21-7-6-17(26)13-19(21)18-8-10-27-25(28-24)23(18)20/h5-8,10,13H,4,9,11-12,14-15H2,1-3H3,(H,27,28)
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US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223819
PNG
(US9328112, 41)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)C(O)=O
Show InChI InChI=1S/C22H20FN3O2/c1-26-11-17-19-15(16-10-14(23)6-7-18(16)26)8-9-24-21(19)25-20(17)12-2-4-13(5-3-12)22(27)28/h2,6-10,13H,3-5,11H2,1H3,(H,24,25)(H,27,28)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223801
PNG
(US9328112, 23)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1CCN(CC(O)=O)CC1
Show InChI InChI=1S/C22H23FN4O2/c1-26-11-17-20-15(16-10-14(23)2-3-18(16)26)4-7-24-22(20)25-21(17)13-5-8-27(9-6-13)12-19(28)29/h2-4,7,10,13H,5-6,8-9,11-12H2,1H3,(H,24,25)(H,28,29)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223833
PNG
(US9328112, 55)
Show SMILES CN(C)C(=O)CN1[C@H]2CC[C@@H]1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C26H28FN5O/c1-30(2)23(33)14-32-17-5-6-18(32)11-15(10-17)25-21-13-31(3)22-7-4-16(27)12-20(22)19-8-9-28-26(29-25)24(19)21/h4,7-10,12,17-18H,5-6,11,13-14H2,1-3H3,(H,28,29)/t17-,18+/m1/s1
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223968
PNG
(US9328112, 190)
Show SMILES CN1CCc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)[C@H]1C[C@@H](C1)C(O)=O
Show InChI InChI=1S/C26H27FN4O2/c1-30-9-7-20-23-19(21-14-17(27)2-3-22(21)30)4-8-28-25(23)29-24(20)15-5-10-31(11-6-15)18-12-16(13-18)26(32)33/h2-5,8,14,16,18H,6-7,9-13H2,1H3,(H,28,29)(H,32,33)/t16-,18-
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


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More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223899
PNG
(US9328112, 121)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(CC(=O)N2CC(O)C2)C1
Show InChI InChI=1S/C25H26FN5O2/c1-29-13-20-23-18(19-9-16(26)4-5-21(19)29)6-7-27-25(23)28-24(20)15-3-2-8-30(10-15)14-22(33)31-11-17(32)12-31/h3-7,9,17,32H,2,8,10-14H2,1H3,(H,27,28)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


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More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223815
PNG
(US9328112, 37)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCC(CC1)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C26H27FN4O2/c1-30-14-20-23-18(19-13-16(27)6-9-21(19)30)10-11-28-25(23)29-24(20)15-4-7-17(8-5-15)31-12-2-3-22(31)26(32)33/h4,6,9-11,13,17,22H,2-3,5,7-8,12,14H2,1H3,(H,28,29)(H,32,33)/t17?,22-/m0/s1
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


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More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223868
PNG
(US9328112, 90)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(CC(O)=O)CC1
Show InChI InChI=1S/C23H23FN4O2/c1-27-12-18-21-16(17-11-15(24)4-5-19(17)27)6-8-25-23(21)26-22(18)14-3-2-9-28(10-7-14)13-20(29)30/h3-6,8,11H,2,7,9-10,12-13H2,1H3,(H,25,26)(H,29,30)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223836
PNG
(US9328112, 58)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=C[C@H]2CC[C@@H](C1)N2CC(O)=O
Show InChI InChI=1S/C24H23FN4O2/c1-28-11-19-22-17(18-10-14(25)2-5-20(18)28)6-7-26-24(22)27-23(19)13-8-15-3-4-16(9-13)29(15)12-21(30)31/h2,5-8,10,15-16H,3-4,9,11-12H2,1H3,(H,26,27)(H,30,31)/t15-,16+/m1/s1
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223874
PNG
(US9328112, 96)
Show SMILES CNC(=O)N1CCC=C(C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C22H22FN5O/c1-24-22(29)28-9-3-4-13(11-28)20-17-12-27(2)18-6-5-14(23)10-16(18)15-7-8-25-21(26-20)19(15)17/h4-8,10H,3,9,11-12H2,1-2H3,(H,24,29)(H,25,26)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223869
PNG
(US9328112, 91)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(CC(=O)N2CC(O)C2)CC1
Show InChI InChI=1S/C26H28FN5O2/c1-30-14-21-24-19(20-11-17(27)4-5-22(20)30)6-8-28-26(24)29-25(21)16-3-2-9-31(10-7-16)15-23(34)32-12-18(33)13-32/h3-6,8,11,18,33H,2,7,9-10,12-15H2,1H3,(H,28,29)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223835
PNG
(US9328112, 57)
Show SMILES CNC(=O)N1[C@H]2CC[C@@H]1C=C(C2)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C24H24FN5O/c1-26-24(31)30-15-4-5-16(30)10-13(9-15)22-19-12-29(2)20-6-3-14(25)11-18(20)17-7-8-27-23(28-22)21(17)19/h3,6-9,11,15-16H,4-5,10,12H2,1-2H3,(H,26,31)(H,27,28)/t15-,16+/m1/s1
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223788
PNG
(US9328112, 10)
Show SMILES CN1C(c2cnn(C)c2)c2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCNCC1
Show InChI InChI=1S/C24H23FN6/c1-30-13-15(12-28-30)23-21-20-17(18-11-16(25)3-4-19(18)31(23)2)7-10-27-24(20)29-22(21)14-5-8-26-9-6-14/h3-5,7,10-13,23,26H,6,8-9H2,1-2H3,(H,27,29)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223780
PNG
(US9328112, 2)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C25H27FN4O2/c1-25(2,3)32-24(31)30-11-8-15(9-12-30)22-19-14-29(4)20-6-5-16(26)13-18(20)17-7-10-27-23(28-22)21(17)19/h5-8,10,13H,9,11-12,14H2,1-4H3,(H,27,28)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223890
PNG
(US9328112, 112)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(CC(O)=O)C1
Show InChI InChI=1S/C22H21FN4O2/c1-26-11-17-20-15(16-9-14(23)4-5-18(16)26)6-7-24-22(20)25-21(17)13-3-2-8-27(10-13)12-19(28)29/h3-7,9H,2,8,10-12H2,1H3,(H,24,25)(H,28,29)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223784
PNG
(US9328112, 6)
Show SMILES CCCN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H25FN4O2S/c1-3-10-27-14-19-21-17(18-13-16(24)4-5-20(18)27)6-9-25-23(21)26-22(19)15-7-11-28(12-8-15)31(2,29)30/h4-7,9,13H,3,8,10-12,14H2,1-2H3,(H,25,26)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223943
PNG
(US9328112, 165)
Show SMILES OC(=O)CC1CCC(CC1)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4OCc1c23
Show InChI InChI=1S/C27H28FN3O3/c28-18-3-6-23-21(14-18)20-7-10-29-27-25(20)22(15-34-23)26(30-27)17-8-11-31(12-9-17)19-4-1-16(2-5-19)13-24(32)33/h3,6-8,10,14,16,19H,1-2,4-5,9,11-13,15H2,(H,29,30)(H,32,33)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223839
PNG
(US9328112, 61)
Show SMILES CCOC(=O)C1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C24H24FN3O2/c1-3-30-24(29)15-6-4-14(5-7-15)22-19-13-28(2)20-9-8-16(25)12-18(20)17-10-11-26-23(27-22)21(17)19/h4,8-12,15H,3,5-7,13H2,1-2H3,(H,26,27)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223877
PNG
(US9328112, 99)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CC2CCCC(C1)N2S(C)(=O)=O
Show InChI InChI=1S/C24H25FN4O2S/c1-28-13-20-22-18(19-12-15(25)6-7-21(19)28)8-9-26-24(22)27-23(20)14-10-16-4-3-5-17(11-14)29(16)32(2,30)31/h6-10,12,16-17H,3-5,11,13H2,1-2H3,(H,26,27)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223799
PNG
(US9328112, 21)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1CCNCC1
Show InChI InChI=1S/C20H21FN4/c1-25-11-16-18-14(15-10-13(21)2-3-17(15)25)6-9-23-20(18)24-19(16)12-4-7-22-8-5-12/h2-3,6,9-10,12,22H,4-5,7-8,11H2,1H3,(H,23,24)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223921
PNG
(US9328112, 143)
Show SMILES CC[C@H]1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCNCC1
Show InChI InChI=1S/C22H23FN4/c1-3-17-20-19-15(16-12-14(23)4-5-18(16)27(17)2)8-11-25-22(19)26-21(20)13-6-9-24-10-7-13/h4-6,8,11-12,17,24H,3,7,9-10H2,1-2H3,(H,25,26)/t17-/m1/s1
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223900
PNG
(US9328112, 122)
Show SMILES CN(C1CC(O)C1)C(=O)CN1CCC=C(C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C27H30FN5O2/c1-31-14-22-25-20(21-10-17(28)5-6-23(21)31)7-8-29-27(25)30-26(22)16-4-3-9-33(13-16)15-24(35)32(2)18-11-19(34)12-18/h4-8,10,18-19,34H,3,9,11-15H2,1-2H3,(H,29,30)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223875
PNG
(US9328112, 97)
Show SMILES CN(C)C(=O)CN1CCC=C(C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C24H26FN5O/c1-28(2)21(31)14-30-10-4-5-15(12-30)23-19-13-29(3)20-7-6-16(25)11-18(20)17-8-9-26-24(27-23)22(17)19/h5-9,11H,4,10,12-14H2,1-3H3,(H,26,27)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223870
PNG
(US9328112, 92)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCNCC1(C)C
Show InChI InChI=1S/C22H23FN4/c1-22(2)12-24-8-7-17(22)20-16-11-27(3)18-5-4-13(23)10-15(18)14-6-9-25-21(26-20)19(14)16/h4-7,9-10,24H,8,11-12H2,1-3H3,(H,25,26)
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Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223898
PNG
(US9328112, 120)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCCN(CC(=O)N2CCC[C@H]2CO)C1
Show InChI InChI=1S/C27H30FN5O2/c1-31-14-22-25-20(21-12-18(28)6-7-23(21)31)8-9-29-27(25)30-26(22)17-4-2-10-32(13-17)15-24(35)33-11-3-5-19(33)16-34/h4,6-9,12,19,34H,2-3,5,10-11,13-16H2,1H3,(H,29,30)/t19-/m0/s1
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n/an/a 480n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223901
PNG
(US9328112, 123)
Show SMILES CN(CC(O)CO)C(=O)CN1CCC=C(C1)c1[nH]c2nccc3-c4cc(F)ccc4N(C)Cc1c23
Show InChI InChI=1S/C26H30FN5O3/c1-30-13-21-24-19(20-10-17(27)5-6-22(20)30)7-8-28-26(24)29-25(21)16-4-3-9-32(11-16)14-23(35)31(2)12-18(34)15-33/h4-8,10,18,33-34H,3,9,11-15H2,1-2H3,(H,28,29)
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n/an/a 540n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223811
PNG
(US9328112, 33)
Show SMILES CN1C(C(O)=O)c2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCNCC1
Show InChI InChI=1S/C21H19FN4O2/c1-26-15-3-2-12(22)10-14(15)13-6-9-24-20-16(13)17(19(26)21(27)28)18(25-20)11-4-7-23-8-5-11/h2-4,6,9-10,19,23H,5,7-8H2,1H3,(H,24,25)(H,27,28)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223891
PNG
(US9328112, 113)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC1(C)C)S(C)(=O)=O
Show InChI InChI=1S/C23H25FN4O2S/c1-23(2)13-28(31(4,29)30)10-8-18(23)21-17-12-27(3)19-6-5-14(24)11-16(19)15-7-9-25-22(26-21)20(15)17/h5-9,11H,10,12-13H2,1-4H3,(H,25,26)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223827
PNG
(US9328112, 49)
Show SMILES CN1Cc2c([nH]c3ncc(F)c(-c4cc(F)ccc14)c23)C1=CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C25H26F2N4O2/c1-25(2,3)33-24(32)31-9-7-14(8-10-31)22-17-13-30(4)19-6-5-15(26)11-16(19)20-18(27)12-28-23(29-22)21(17)20/h5-7,11-12H,8-10,13H2,1-4H3,(H,28,29)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223785
PNG
(US9328112, 7)
Show SMILES CS(=O)(=O)N1CCC(=CC1)c1[nH]c2nccc3-c4cc(F)ccc4N(CC4CCOCC4)Cc1c23
Show InChI InChI=1S/C26H29FN4O3S/c1-35(32,33)31-10-5-18(6-11-31)25-22-16-30(15-17-7-12-34-13-8-17)23-3-2-19(27)14-21(23)20-4-9-28-26(29-25)24(20)22/h2-5,9,14,17H,6-8,10-13,15-16H2,1H3,(H,28,29)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223892
PNG
(US9328112, 114)
Show SMILES CN(C)C(=O)CN1CC=C(c2[nH]c3nccc4-c5cc(F)ccc5N(C)Cc2c34)C(C)(C)C1
Show InChI InChI=1S/C26H30FN5O/c1-26(2)15-32(14-22(33)30(3)4)11-9-20(26)24-19-13-31(5)21-7-6-16(27)12-18(21)17-8-10-28-25(29-24)23(17)19/h6-10,12H,11,13-15H2,1-5H3,(H,28,29)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223894
PNG
(US9328112, 116)
Show SMILES CN(CCO)C(=O)CN1CC=C(c2[nH]c3nccc4-c5cc(F)ccc5N(C)Cc2c34)C(C)(C)C1
Show InChI InChI=1S/C27H32FN5O2/c1-27(2)16-33(15-23(35)31(3)11-12-34)10-8-21(27)25-20-14-32(4)22-6-5-17(28)13-19(22)18-7-9-29-26(30-25)24(18)20/h5-9,13,34H,10-12,14-16H2,1-4H3,(H,29,30)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223893
PNG
(US9328112, 115)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CCC[C@H]2CO)CC1(C)C
Show InChI InChI=1S/C29H34FN5O2/c1-29(2)17-34(15-25(37)35-11-4-5-19(35)16-36)12-9-23(29)27-22-14-33(3)24-7-6-18(30)13-21(24)20-8-10-31-28(32-27)26(20)22/h6-10,13,19,36H,4-5,11-12,14-17H2,1-3H3,(H,31,32)/t19-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223895
PNG
(US9328112, 117)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(=O)N2CC(O)C2)CC1(C)C
Show InChI InChI=1S/C27H30FN5O2/c1-27(2)15-32(14-23(35)33-11-17(34)12-33)9-7-21(27)25-20-13-31(3)22-5-4-16(28)10-19(22)18-6-8-29-26(30-25)24(18)20/h4-8,10,17,34H,9,11-15H2,1-3H3,(H,29,30)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223896
PNG
(US9328112, 118)
Show SMILES CN(C1CC(O)C1)C(=O)CN1CC=C(c2[nH]c3nccc4-c5cc(F)ccc5N(C)Cc2c34)C(C)(C)C1
Show InChI InChI=1S/C29H34FN5O2/c1-29(2)16-35(15-25(37)34(4)18-12-19(36)13-18)10-8-23(29)27-22-14-33(3)24-6-5-17(30)11-21(24)20-7-9-31-28(32-27)26(20)22/h5-9,11,18-19,36H,10,12-16H2,1-4H3,(H,31,32)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223897
PNG
(US9328112, 119)
Show SMILES CN(CC(O)CO)C(=O)CN1CC=C(c2[nH]c3nccc4-c5cc(F)ccc5N(C)Cc2c34)C(C)(C)C1
Show InChI InChI=1S/C28H34FN5O3/c1-28(2)16-34(14-24(37)33(4)12-18(36)15-35)10-8-22(28)26-21-13-32(3)23-6-5-17(29)11-20(23)19-7-9-30-27(31-26)25(19)21/h5-9,11,18,35-36H,10,12-16H2,1-4H3,(H,30,31)
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n/an/a 1.30E+3n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223786
PNG
(US9328112, 8)
Show SMILES CCC1N(C)c2ccc(F)cc2-c2ccnc3[nH]c(c1c23)C1=CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C27H31FN4O2/c1-6-20-23-22-18(19-15-17(28)7-8-21(19)31(20)5)9-12-29-25(22)30-24(23)16-10-13-32(14-11-16)26(33)34-27(2,3)4/h7-10,12,15,20H,6,11,13-14H2,1-5H3,(H,29,30)
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n/an/a 1.40E+3n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223889
PNG
(US9328112, 111)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1=CCN(CC(O)=O)CC1(C)C
Show InChI InChI=1S/C24H25FN4O2/c1-24(2)13-29(12-20(30)31)9-7-18(24)22-17-11-28(3)19-5-4-14(25)10-16(19)15-6-8-26-23(27-22)21(15)17/h4-8,10H,9,11-13H2,1-3H3,(H,26,27)(H,30,31)
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AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223800
PNG
(US9328112, 22)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)C1CCN(CC(=O)OC(C)(C)C)CC1
Show InChI InChI=1S/C26H31FN4O2/c1-26(2,3)33-22(32)15-31-11-8-16(9-12-31)24-20-14-30(4)21-6-5-17(27)13-19(21)18-7-10-28-25(29-24)23(18)20/h5-7,10,13,16H,8-9,11-12,14-15H2,1-4H3,(H,28,29)
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n/an/a 2.80E+3n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM223824
PNG
(US9328112, 46)
Show SMILES CN1Cc2c([nH]c3nccc(-c4cc(F)ccc14)c23)-c1cnc(N)nc1
Show InChI InChI=1S/C19H15FN6/c1-26-9-14-16-12(13-6-11(20)2-3-15(13)26)4-5-22-18(16)25-17(14)10-7-23-19(21)24-8-10/h2-8H,9H2,1H3,(H,22,25)(H2,21,23,24)
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n/an/a 3.30E+3n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were diluted in 100% D...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%