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Patent code US9333195

Compile Data Set for Download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50296329
PNG
((3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(2-phe...)
Show SMILES OC(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1
Show InChI InChI=1S/C25H28NO3S2/c27-24(25(28,22-8-4-16-30-22)23-9-5-17-31-23)29-21-18-26(14-11-20(21)12-15-26)13-10-19-6-2-1-3-7-19/h1-9,16-17,20-21,28H,10-15,18H2/q+1/t20?,21-,26?/m0/s1
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n/an/a 2.70n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228865
PNG
(Ipratropium | US9333195, IPRATROPIUM)
Show SMILES CC(C)[N+]1(C)[C@H]2CC[C@@H]1CC(C2)OC(=O)C(CO)c1ccccc1
Show InChI InChI=1S/C20H30NO3/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15/h4-8,14,16-19,22H,9-13H2,1-3H3/q+1/t16-,17+,18?,19?,21?
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n/an/a 3n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228855
PNG
(US9333195, 77 | US9687478, 77)
Show SMILES OC(C(=O)O[C@H]1C[N+]2(CCc3cccs3)CCC1CC2)(c1cccs1)c1cccs1
Show InChI InChI=1S/C23H26NO3S3/c25-22(23(26,20-5-2-14-29-20)21-6-3-15-30-21)27-19-16-24(10-7-17(19)8-11-24)12-9-18-4-1-13-28-18/h1-6,13-15,17,19,26H,7-12,16H2/q+1/t17?,19-,24?/m0/s1
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n/an/a 3.10n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM86231
PNG
(ATR | ATROPINE | Atropine,(-) | CAS_51-55-8 | CHEM...)
Show SMILES CN1C2CCC1CC(C2)OC(=O)C(CO)c1ccccc1
Show InChI InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3
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n/an/a 3.20n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50296330
PNG
((3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(4-phe...)
Show SMILES OC(C(=O)O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1
Show InChI InChI=1S/C27H32NO3S2/c29-26(27(30,24-11-6-18-32-24)25-12-7-19-33-25)31-23-20-28(16-13-22(23)14-17-28)15-5-4-10-21-8-2-1-3-9-21/h1-3,6-9,11-12,18-19,22-23,30H,4-5,10,13-17,20H2/q+1/t22?,23-,28?/m0/s1
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n/an/a 3.80n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50296331
PNG
((3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phe...)
Show SMILES OC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1
Show InChI InChI=1S/C26H30NO4S2/c28-25(26(29,23-9-4-17-32-23)24-10-5-18-33-24)31-22-19-27(14-11-20(22)12-15-27)13-6-16-30-21-7-2-1-3-8-21/h1-5,7-10,17-18,20,22,29H,6,11-16,19H2/q+1/t20?,22-,27?/m0/s1
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n/an/a 4.40n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228848
PNG
(US9333195, 8 | US9687478, 8)
Show SMILES OC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1ccccc1
Show InChI InChI=1S/C28H32NO4S/c30-27(28(31,26-13-7-20-34-26)23-9-3-1-4-10-23)33-25-21-29(17-14-22(25)15-18-29)16-8-19-32-24-11-5-2-6-12-24/h1-7,9-13,20,22,25,31H,8,14-19,21H2/q+1/t22?,25-,28?,29?/m0/s1
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n/an/a 4.80n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228856
PNG
(US9333195, 78 | US9687478, 78)
Show SMILES OC(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)(c1cccs1)c1cccs1
Show InChI InChI=1S/C24H28NO3S3/c26-23(24(27,21-7-3-15-30-21)22-8-4-16-31-22)28-20-17-25(12-9-18(20)10-13-25)11-1-5-19-6-2-14-29-19/h2-4,6-8,14-16,18,20,27H,1,5,9-13,17H2/q+1/t18?,20-,25?/m0/s1
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n/an/a 5n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50296341
PNG
((3R)-3-{[Hydroxy(di-3-thienyl)acetyl]oxy}-1-(3-phe...)
Show SMILES OC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1ccsc1)c1ccsc1
Show InChI InChI=1S/C26H30NO4S2/c28-25(26(29,21-9-15-32-18-21)22-10-16-33-19-22)31-24-17-27(12-7-20(24)8-13-27)11-4-14-30-23-5-2-1-3-6-23/h1-3,5-6,9-10,15-16,18-20,24,29H,4,7-8,11-14,17H2/q+1/t20?,24-,27?/m0/s1
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n/an/a 5.40n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228852
PNG
(US9333195, 53 | US9687478, 53)
Show SMILES OC(C(=O)O[C@H]1C[N+]2(CCCOc3ccc(F)cc3)CCC1CC2)(c1cccs1)c1cccs1
Show InChI InChI=1S/C26H29FNO4S2/c27-20-6-8-21(9-7-20)31-15-3-12-28-13-10-19(11-14-28)22(18-28)32-25(29)26(30,23-4-1-16-33-23)24-5-2-17-34-24/h1-2,4-9,16-17,19,22,30H,3,10-15,18H2/q+1/t19?,22-,28?/m0/s1
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n/an/a 5.60n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50296332
PNG
((3R)-1-(2-Phenylethyl)-3-[(9H-xanthen-9-ylcarbonyl...)
Show SMILES O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc12
Show InChI InChI=1S/C29H30NO3/c31-29(28-23-10-4-6-12-25(23)32-26-13-7-5-11-24(26)28)33-27-20-30(18-15-22(27)16-19-30)17-14-21-8-2-1-3-9-21/h1-13,22,27-28H,14-20H2/q+1/t22?,27-,30?/m0/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228850
PNG
(US9333195, 18 | US9687478, 18)
Show SMILES OC(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)(c1ccco1)c1ccccc1
Show InChI InChI=1S/C27H30NO5/c29-26(27(30,25-12-7-18-32-25)22-8-3-1-4-9-22)33-24-20-28(15-13-21(24)14-16-28)17-19-31-23-10-5-2-6-11-23/h1-12,18,21,24,30H,13-17,19-20H2/q+1/t21?,24-,27?,28?/m0/s1
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n/an/a 6.60n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228851
PNG
(US9333195, 20 | US9687478, 20)
Show SMILES OC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1ccco1)c1ccccc1
Show InChI InChI=1S/C28H32NO5/c30-27(28(31,26-13-7-19-33-26)23-9-3-1-4-10-23)34-25-21-29(17-14-22(25)15-18-29)16-8-20-32-24-11-5-2-6-12-24/h1-7,9-13,19,22,25,31H,8,14-18,20-21H2/q+1/t22?,25-,28?,29?/m0/s1
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n/an/a 6.80n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50296333
PNG
((3R)-3-{[(9-Hydroxy-9H-xanthen-9-yl)carbonyl]oxy}-...)
Show SMILES OC1(C(=O)O[C@H]2C[N+]3(CCc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc12
Show InChI InChI=1S/C29H30NO4/c31-28(29(32)23-10-4-6-12-25(23)33-26-13-7-5-11-24(26)29)34-27-20-30(18-15-22(27)16-19-30)17-14-21-8-2-1-3-9-21/h1-13,22,27,32H,14-20H2/q+1/t22?,27-,30?/m0/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50296324
PNG
((3R)-3-{[(9-Hydroxy-9H-fluoren-9-yl)carbonyl]oxy}-...)
Show SMILES OC1(C(=O)O[C@H]2C[N+]3(CCc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C29H30NO3/c31-28(29(32)25-12-6-4-10-23(25)24-11-5-7-13-26(24)29)33-27-20-30(18-15-22(27)16-19-30)17-14-21-8-2-1-3-9-21/h1-13,22,27,32H,14-20H2/q+1/t22?,27-,30?/m0/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228853
PNG
(US9333195, 71 | US9687478, 71)
Show SMILES Oc1ccccc1OCCC[N+]12CCC(CC1)[C@H](C2)OC(=O)C(O)(c1cccs1)c1cccs1
Show InChI InChI=1S/C26H29NO5S2/c28-20-6-1-2-7-21(20)31-15-5-12-27-13-10-19(11-14-27)22(18-27)32-25(29)26(30,23-8-3-16-33-23)24-9-4-17-34-24/h1-4,6-9,16-17,19,22,30H,5,10-15,18H2/p+1/t19?,22-,27?/m0/s1
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n/an/a 8.20n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228863
PNG
(US9333195, 128)
Show SMILES O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc12
Show InChI InChI=1S/C30H32NO4/c32-30(29-24-11-4-6-13-26(24)34-27-14-7-5-12-25(27)29)35-28-21-31(18-15-22(28)16-19-31)17-8-20-33-23-9-2-1-3-10-23/h1-7,9-14,22,28-29H,8,15-21H2/q+1/t22?,28-,31?/m0/s1
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n/an/a 8.80n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228857
PNG
(US9333195, 84 | US9687478, 84)
Show SMILES OC(C(=O)O[C@H]1C[N+]2(CCOCc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1
Show InChI InChI=1S/C26H30NO4S2/c28-25(26(29,23-8-4-16-32-23)24-9-5-17-33-24)31-22-18-27(12-10-21(22)11-13-27)14-15-30-19-20-6-2-1-3-7-20/h1-9,16-17,21-22,29H,10-15,18-19H2/q+1/t21?,22-,27?/m0/s1
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n/an/a 9.90n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50296334
PNG
((3R)-3-{[(9-Hydroxy-9H-xanthen-9-yl)carbonyl]oxy}-...)
Show SMILES OC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc12
Show InChI InChI=1S/C30H32NO5/c32-29(30(33)24-11-4-6-13-26(24)35-27-14-7-5-12-25(27)30)36-28-21-31(18-15-22(28)16-19-31)17-8-20-34-23-9-2-1-3-10-23/h1-7,9-14,22,28,33H,8,15-21H2/q+1/t22?,28-,31?/m0/s1
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n/an/a 11n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228861
PNG
(US9333195, 126)
Show SMILES O=C(O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc12
Show InChI InChI=1S/C31H34NO3/c33-31(30-25-13-4-6-15-27(25)34-28-16-7-5-14-26(28)30)35-29-22-32(20-17-24(29)18-21-32)19-9-8-12-23-10-2-1-3-11-23/h1-7,10-11,13-16,24,29-30H,8-9,12,17-22H2/q+1/t24?,29-,32?/m0/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50296340
PNG
((3R)-3-[(Di-2-thienylacetyl)oxy]-1-(3-phenoxypropy...)
Show SMILES O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1
Show InChI InChI=1S/C26H30NO3S2/c28-26(25(23-9-4-17-31-23)24-10-5-18-32-24)30-22-19-27(14-11-20(22)12-15-27)13-6-16-29-21-7-2-1-3-8-21/h1-5,7-10,17-18,20,22,25H,6,11-16,19H2/q+1/t20?,22-,27?/m0/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50296338
PNG
((3R)-3-{[(9-Methyl-9H-xanthen-9-yl)carbonyl]oxy}-1...)
Show SMILES CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc12
Show InChI InChI=1S/C31H34NO4/c1-31(25-12-5-7-14-27(25)35-28-15-8-6-13-26(28)31)30(33)36-29-22-32(19-16-23(29)17-20-32)18-9-21-34-24-10-3-2-4-11-24/h2-8,10-15,23,29H,9,16-22H2,1H3/q+1/t23?,29-,32?/m0/s1
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n/an/a 13n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228849
PNG
(US9333195, 17 | US9687478, 17)
Show SMILES OC(C(=O)O[C@H]1C[N+]2(C\C=C\c3ccccc3)CCC1CC2)(c1ccco1)c1ccccc1
Show InChI InChI=1S/C28H30NO4/c30-27(28(31,26-14-8-20-32-26)24-12-5-2-6-13-24)33-25-21-29(18-15-23(25)16-19-29)17-7-11-22-9-3-1-4-10-22/h1-14,20,23,25,31H,15-19,21H2/q+1/b11-7+/t23?,25-,28?,29?/m0/s1
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n/an/a 14n/an/an/an/an/an/a



ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228860
PNG
(US9333195, 114)
Show SMILES CC1(C(=O)O[C@H]2C[N+]3(C\C=C\c4ccccc4)CCC2CC3)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C31H32NO2/c1-31(27-15-7-5-13-25(27)26-14-6-8-16-28(26)31)30(33)34-29-22-32(20-17-24(29)18-21-32)19-9-12-23-10-3-2-4-11-23/h2-16,24,29H,17-22H2,1H3/q+1/b12-9+/t24?,29-,32?/m0/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50296325
PNG
((3R)-3-{[(9-Hydroxy-9H-fluoren-9-yl)carbonyl]oxy}-...)
Show SMILES OC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C30H32NO4/c32-29(30(33)26-13-6-4-11-24(26)25-12-5-7-14-27(25)30)35-28-21-31(18-15-22(28)16-19-31)17-8-20-34-23-9-2-1-3-10-23/h1-7,9-14,22,28,33H,8,15-21H2/q+1/t22?,28-,31?/m0/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50296335
PNG
((3R)-3-{[Hydroxy(diphenyl)acetyl]oxy}-1-(3-phenoxy...)
Show SMILES OC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H34NO4/c32-29(30(33,25-11-4-1-5-12-25)26-13-6-2-7-14-26)35-28-23-31(20-17-24(28)18-21-31)19-10-22-34-27-15-8-3-9-16-27/h1-9,11-16,24,28,33H,10,17-23H2/q+1/t24?,28-,31?/m0/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228854
PNG
(US9333195, 74 | US9687478, 74)
Show SMILES OC(C(=O)O[C@H]1C[N+]2(CCCn3cccc3)CCC1CC2)(c1cccs1)c1cccs1
Show InChI InChI=1S/C24H29N2O3S2/c27-23(24(28,21-6-3-16-30-21)22-7-4-17-31-22)29-20-18-26(14-8-19(20)9-15-26)13-5-12-25-10-1-2-11-25/h1-4,6-7,10-11,16-17,19-20,28H,5,8-9,12-15,18H2/q+1/t19?,20-,26?/m0/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228862
PNG
(US9333195, 127)
Show SMILES O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc12
Show InChI InChI=1S/C29H30NO4/c31-29(28-23-10-4-6-12-25(23)33-26-13-7-5-11-24(26)28)34-27-20-30(16-14-21(27)15-17-30)18-19-32-22-8-2-1-3-9-22/h1-13,21,27-28H,14-20H2/q+1/t21?,27-,30?/m0/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228864
PNG
(US9333195, 138)
Show SMILES OC1(C(=O)O[C@H]2C[N+]3(CCCc4cccs4)CCC2CC3)c2ccccc2Oc2ccccc12
Show InChI InChI=1S/C28H30NO4S/c30-27(28(31)22-9-1-3-11-24(22)32-25-12-4-2-10-23(25)28)33-26-19-29(16-13-20(26)14-17-29)15-5-7-21-8-6-18-34-21/h1-4,6,8-12,18,20,26,31H,5,7,13-17,19H2/q+1/t20?,26-,29?/m0/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228847
PNG
(US9333195, 7 | US9687478, 7)
Show SMILES CC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H36NO3/c1-31(26-12-5-2-6-13-26,27-14-7-3-8-15-27)30(33)35-29-24-32(21-18-25(29)19-22-32)20-11-23-34-28-16-9-4-10-17-28/h2-10,12-17,25,29H,11,18-24H2,1H3/q+1/t25?,29-,32?/m0/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50296339
PNG
((3R)-3-{[(9-Methyl-9H-fluoren-9-yl)carbonyl]oxy}-1...)
Show SMILES CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C31H34NO3/c1-31(27-14-7-5-12-25(27)26-13-6-8-15-28(26)31)30(33)35-29-22-32(19-16-23(29)17-20-32)18-9-21-34-24-10-3-2-4-11-24/h2-8,10-15,23,29H,9,16-22H2,1H3/q+1/t23?,29-,32?/m0/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228846
PNG
(US9333195, 1)
Show SMILES O=C(O[C@@H]1CC2CC[N+]1(CCCOc1ccccc1)CC2)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H34NO3/c32-30(29(25-11-4-1-5-12-25)26-13-6-2-7-14-26)34-28-23-24-17-20-31(28,21-18-24)19-10-22-33-27-15-8-3-9-16-27/h1-9,11-16,24,28-29H,10,17-23H2/q+1/t24?,28-,31?/m1/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228858
PNG
(US9333195, 99)
Show SMILES OC1(C(=O)O[C@H]2C[N+]3(C\C=C\c4ccccc4)CCC2CC3)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C30H30NO3/c32-29(30(33)26-14-6-4-12-24(26)25-13-5-7-15-27(25)30)34-28-21-31(19-16-23(28)17-20-31)18-8-11-22-9-2-1-3-10-22/h1-15,23,28,33H,16-21H2/q+1/b11-8+/t23?,28-,31?/m0/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM228859
PNG
(US9333195, 109)
Show SMILES CCC1(c2ccsc12)[N+]12CCC(CC1)[C@H](C2)OC(=O)C1(O)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C28H28NO3S/c1-2-27(23-13-16-33-25(23)27)29-14-11-18(12-15-29)24(17-29)32-26(30)28(31)21-9-5-3-7-19(21)20-8-4-6-10-22(20)28/h3-10,13,16,18,24,31H,2,11-12,14-15,17H2,1H3/q+1/t18?,24-,27?,29?/m0/s1
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ALMIRALL, S.A.

US Patent


Assay Description
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25 C. Membra...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%