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Patent code US9334269

Compile Data Set for Download or QSAR

Found 337 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229646
PNG
(BDBM229674 | US9334269, J)
Show SMILES CNC(=O)c1cccc(Nc2nccc(n2)N2CC(C2)Oc2ccc(F)cc2C)c1
Show InChI InChI=1S/C22H22FN5O2/c1-14-10-16(23)6-7-19(14)30-18-12-28(13-18)20-8-9-25-22(27-20)26-17-5-3-4-15(11-17)21(29)24-2/h3-11,18H,12-13H2,1-2H3,(H,24,29)(H,25,26,27)
PDB

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US Patent
n/an/a 80n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229646
PNG
(BDBM229674 | US9334269, J)
Show SMILES CNC(=O)c1cccc(Nc2nccc(n2)N2CC(C2)Oc2ccc(F)cc2C)c1
Show InChI InChI=1S/C22H22FN5O2/c1-14-10-16(23)6-7-19(14)30-18-12-28(13-18)20-8-9-25-22(27-20)26-17-5-3-4-15(11-17)21(29)24-2/h3-11,18H,12-13H2,1-2H3,(H,24,29)(H,25,26,27)
PDB

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n/an/a 80n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229675
PNG
(US9334269, 2)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C20H19ClN6O2/c1-22-18(28)13-3-2-4-15(9-13)25-19-23-12-24-20(26-19)27-10-17(11-27)29-16-7-5-14(21)6-8-16/h2-9,12,17H,10-11H2,1H3,(H,22,28)(H,23,24,25,26)
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n/an/a 150n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229676
PNG
(US9334269, 3)
Show SMILES CNC(=O)c1cc(Nc2ncnc(n2)N2CCC(CC2)c2nc(cs2)-c2ccccc2)ccc1F
Show InChI InChI=1S/C25H24FN7OS/c1-27-22(34)19-13-18(7-8-20(19)26)30-24-28-15-29-25(32-24)33-11-9-17(10-12-33)23-31-21(14-35-23)16-5-3-2-4-6-16/h2-8,13-15,17H,9-12H2,1H3,(H,27,34)(H,28,29,30,32)
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n/an/a 170n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229677
PNG
(US9334269, 4)
Show SMILES CNC(=O)c1cc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(Cl)cc2)ccc1F
Show InChI InChI=1S/C20H18ClFN6O2/c1-23-18(29)16-8-13(4-7-17(16)22)26-19-24-11-25-20(27-19)28-9-15(10-28)30-14-5-2-12(21)3-6-14/h2-8,11,15H,9-10H2,1H3,(H,23,29)(H,24,25,26,27)
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n/an/a 190n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229678
PNG
(US9334269, 5)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(COc3ccc(cc3)C(F)(F)F)C2)c1
Show InChI InChI=1S/C22H21F3N6O2/c1-26-19(32)15-3-2-4-17(9-15)29-20-27-13-28-21(30-20)31-10-14(11-31)12-33-18-7-5-16(6-8-18)22(23,24)25/h2-9,13-14H,10-12H2,1H3,(H,26,32)(H,27,28,29,30)
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n/an/a 200n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229680
PNG
(US9334269, 7)
Show SMILES CNC(=O)c1cccc(Nc2ccnc(n2)N2CC(C2)Oc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C21H20ClN5O2/c1-23-20(28)14-3-2-4-16(11-14)25-19-9-10-24-21(26-19)27-12-18(13-27)29-17-7-5-15(22)6-8-17/h2-11,18H,12-13H2,1H3,(H,23,28)(H,24,25,26)
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n/an/a 210n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229679
PNG
(US9334269, 6)
Show SMILES CNC(=O)c1cc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(cc2)C(F)(F)F)ccc1F
Show InChI InChI=1S/C21H18F4N6O2/c1-26-18(32)16-8-13(4-7-17(16)22)29-19-27-11-28-20(30-19)31-9-15(10-31)33-14-5-2-12(3-6-14)21(23,24)25/h2-8,11,15H,9-10H2,1H3,(H,26,32)(H,27,28,29,30)
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n/an/a 210n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229682
PNG
(US9334269, 9)
Show SMILES CNC(=O)c1cc(Nc2ncnc(n2)N2CCc3cc(OCC(F)(F)F)ccc3C2)ccc1Cl
Show InChI InChI=1S/C22H20ClF3N6O2/c1-27-19(33)17-9-15(3-5-18(17)23)30-20-28-12-29-21(31-20)32-7-6-13-8-16(4-2-14(13)10-32)34-11-22(24,25)26/h2-5,8-9,12H,6-7,10-11H2,1H3,(H,27,33)(H,28,29,30,31)
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n/an/a 230n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229681
PNG
(US9334269, 8)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(Cl)c(C)c2)c1
Show InChI InChI=1S/C21H21ClN6O2/c1-13-8-16(6-7-18(13)22)30-17-10-28(11-17)21-25-12-24-20(27-21)26-15-5-3-4-14(9-15)19(29)23-2/h3-9,12,17H,10-11H2,1-2H3,(H,23,29)(H,24,25,26,27)
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n/an/a 230n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229684
PNG
(US9334269, 11)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(Cl)c(F)c2)c1
Show InChI InChI=1S/C20H18ClFN6O2/c1-23-18(29)12-3-2-4-13(7-12)26-19-24-11-25-20(27-19)28-9-15(10-28)30-14-5-6-16(21)17(22)8-14/h2-8,11,15H,9-10H2,1H3,(H,23,29)(H,24,25,26,27)
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n/an/a 250n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229683
PNG
(US9334269, 10)
Show SMILES CNC(=O)c1cccc(Nc2nccc(n2)N2CC(C2)Oc2ccc(F)cc2)c1
Show InChI InChI=1S/C21H20FN5O2/c1-23-20(28)14-3-2-4-16(11-14)25-21-24-10-9-19(26-21)27-12-18(13-27)29-17-7-5-15(22)6-8-17/h2-11,18H,12-13H2,1H3,(H,23,28)(H,24,25,26)
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n/an/a 250n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229650
PNG
(BDBM229685 | US9334269, N)
Show SMILES CNC(=O)c1cccc(Nc2nccc(n2)N2CC(C2)Oc2ccc(Cl)cc2C)c1
Show InChI InChI=1S/C22H22ClN5O2/c1-14-10-16(23)6-7-19(14)30-18-12-28(13-18)20-8-9-25-22(27-20)26-17-5-3-4-15(11-17)21(29)24-2/h3-11,18H,12-13H2,1-2H3,(H,24,29)(H,25,26,27)
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n/an/a 260n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229650
PNG
(BDBM229685 | US9334269, N)
Show SMILES CNC(=O)c1cccc(Nc2nccc(n2)N2CC(C2)Oc2ccc(Cl)cc2C)c1
Show InChI InChI=1S/C22H22ClN5O2/c1-14-10-16(23)6-7-19(14)30-18-12-28(13-18)20-8-9-25-22(27-20)26-17-5-3-4-15(11-17)21(29)24-2/h3-11,18H,12-13H2,1-2H3,(H,24,29)(H,25,26,27)
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n/an/a 260n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229686
PNG
(US9334269, 13)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(NCCCOc3ccc(OC(F)(F)F)cc3)n2)c1
Show InChI InChI=1S/C21H21F3N6O3/c1-25-18(31)14-4-2-5-15(12-14)29-20-28-13-27-19(30-20)26-10-3-11-32-16-6-8-17(9-7-16)33-21(22,23)24/h2,4-9,12-13H,3,10-11H2,1H3,(H,25,31)(H2,26,27,28,29,30)
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n/an/a 270n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229687
PNG
(US9334269, 14)
Show SMILES CNC(=O)c1cc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(Cl)cc2F)ccc1F
Show InChI InChI=1S/C20H17ClF2N6O2/c1-24-18(30)14-7-12(3-4-15(14)22)27-19-25-10-26-20(28-19)29-8-13(9-29)31-17-5-2-11(21)6-16(17)23/h2-7,10,13H,8-9H2,1H3,(H,24,30)(H,25,26,27,28)
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n/an/a 280n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229688
PNG
(US9334269, 15)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C20H18ClFN6O2/c1-23-18(29)12-3-2-4-13(7-12)26-19-24-11-25-20(27-19)28-9-15(10-28)30-14-5-6-17(22)16(21)8-14/h2-8,11,15H,9-10H2,1H3,(H,23,29)(H,24,25,26,27)
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n/an/a 280n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229689
PNG
(US9334269, 16)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(F)cc2C)c1
Show InChI InChI=1S/C21H21FN6O2/c1-13-8-15(22)6-7-18(13)30-17-10-28(11-17)21-25-12-24-20(27-21)26-16-5-3-4-14(9-16)19(29)23-2/h3-9,12,17H,10-11H2,1-2H3,(H,23,29)(H,24,25,26,27)
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n/an/a 290n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229690
PNG
(US9334269, 17)
Show SMILES CCc1cccc(OC2CN(C2)c2ncnc(Nc3cccc(c3)C(=O)NC)n2)c1
Show InChI InChI=1S/C22H24N6O2/c1-3-15-6-4-9-18(10-15)30-19-12-28(13-19)22-25-14-24-21(27-22)26-17-8-5-7-16(11-17)20(29)23-2/h4-11,14,19H,3,12-13H2,1-2H3,(H,23,29)(H,24,25,26,27)
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n/an/a 300n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229648
PNG
(BDBM229692 | US9334269, L)
Show SMILES CNC(=O)c1cccc(Nc2nccc(n2)N2CC(C2)Oc2ccc(Cl)c(C)c2)c1
Show InChI InChI=1S/C22H22ClN5O2/c1-14-10-17(6-7-19(14)23)30-18-12-28(13-18)20-8-9-25-22(27-20)26-16-5-3-4-15(11-16)21(29)24-2/h3-11,18H,12-13H2,1-2H3,(H,24,29)(H,25,26,27)
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n/an/a 310n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229691
PNG
(US9334269, 18)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2cc(Cl)ccc2Cl)c1
Show InChI InChI=1S/C20H18Cl2N6O2/c1-23-18(29)12-3-2-4-14(7-12)26-19-24-11-25-20(27-19)28-9-15(10-28)30-17-8-13(21)5-6-16(17)22/h2-8,11,15H,9-10H2,1H3,(H,23,29)(H,24,25,26,27)
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n/an/a 310n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229648
PNG
(BDBM229692 | US9334269, L)
Show SMILES CNC(=O)c1cccc(Nc2nccc(n2)N2CC(C2)Oc2ccc(Cl)c(C)c2)c1
Show InChI InChI=1S/C22H22ClN5O2/c1-14-10-17(6-7-19(14)23)30-18-12-28(13-18)20-8-9-25-22(27-20)26-16-5-3-4-15(11-16)21(29)24-2/h3-11,18H,12-13H2,1-2H3,(H,24,29)(H,25,26,27)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229693
PNG
(US9334269, 20)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(Cl)cc2C)c1
Show InChI InChI=1S/C21H21ClN6O2/c1-13-8-15(22)6-7-18(13)30-17-10-28(11-17)21-25-12-24-20(27-21)26-16-5-3-4-14(9-16)19(29)23-2/h3-9,12,17H,10-11H2,1-2H3,(H,23,29)(H,24,25,26,27)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229653
PNG
(BDBM229694 | US9334269, Q)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(Cl)cc2F)c1
Show InChI InChI=1S/C20H18ClFN6O2/c1-23-18(29)12-3-2-4-14(7-12)26-19-24-11-25-20(27-19)28-9-15(10-28)30-17-6-5-13(21)8-16(17)22/h2-8,11,15H,9-10H2,1H3,(H,23,29)(H,24,25,26,27)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229670
PNG
(US9334269, AH)
Show SMILES CNC(=O)c1cccc(Nc2nc(ncc2F)N2CC(C2)Oc2ccc(F)cc2)c1
Show InChI InChI=1S/C21H19F2N5O2/c1-24-20(29)13-3-2-4-15(9-13)26-19-18(23)10-25-21(27-19)28-11-17(12-28)30-16-7-5-14(22)6-8-16/h2-10,17H,11-12H2,1H3,(H,24,29)(H,25,26,27)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229695
PNG
(US9334269, 22)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccc3CCCc3c2)c1
Show InChI InChI=1S/C23H24N6O2/c1-24-21(30)17-6-3-7-18(10-17)27-22-25-14-26-23(28-22)29-12-20(13-29)31-19-9-8-15-4-2-5-16(15)11-19/h3,6-11,14,20H,2,4-5,12-13H2,1H3,(H,24,30)(H,25,26,27,28)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229696
PNG
(US9334269, 23)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CCN(CC2)c2cccc(OC(F)(F)F)c2)c1
Show InChI InChI=1S/C22H22F3N7O2/c1-26-19(33)15-4-2-5-16(12-15)29-20-27-14-28-21(30-20)32-10-8-31(9-11-32)17-6-3-7-18(13-17)34-22(23,24)25/h2-7,12-14H,8-11H2,1H3,(H,26,33)(H,27,28,29,30)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229697
PNG
(US9334269, 24)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CCC(CC2)c2nc(cs2)-c2ccccc2)c1
Show InChI InChI=1S/C25H25N7OS/c1-26-22(33)19-8-5-9-20(14-19)29-24-27-16-28-25(31-24)32-12-10-18(11-13-32)23-30-21(15-34-23)17-6-3-2-4-7-17/h2-9,14-16,18H,10-13H2,1H3,(H,26,33)(H,27,28,29,31)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229698
PNG
(US9334269, 25)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2cccc(Cl)c2)c1
Show InChI InChI=1S/C20H19ClN6O2/c1-22-18(28)13-4-2-6-15(8-13)25-19-23-12-24-20(26-19)27-10-17(11-27)29-16-7-3-5-14(21)9-16/h2-9,12,17H,10-11H2,1H3,(H,22,28)(H,23,24,25,26)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229699
PNG
(US9334269, 26)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CCC(CC2)c2csc(n2)-c2ccccc2)c1
Show InChI InChI=1S/C25H25N7OS/c1-26-22(33)19-8-5-9-20(14-19)29-24-27-16-28-25(31-24)32-12-10-17(11-13-32)21-15-34-23(30-21)18-6-3-2-4-7-18/h2-9,14-17H,10-13H2,1H3,(H,26,33)(H,27,28,29,31)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229700
PNG
(US9334269, 27)
Show SMILES CNC(=O)c1cc(Nc2ncnc(n2)N2CCC(CC2)c2nc(cs2)-c2ccccc2)ccc1Cl
Show InChI InChI=1S/C25H24ClN7OS/c1-27-22(34)19-13-18(7-8-20(19)26)30-24-28-15-29-25(32-24)33-11-9-17(10-12-33)23-31-21(14-35-23)16-5-3-2-4-6-16/h2-8,13-15,17H,9-12H2,1H3,(H,27,34)(H,28,29,30,32)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229701
PNG
(US9334269, 28)
Show SMILES COCCNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C22H23ClN6O3/c1-31-10-9-24-20(30)15-3-2-4-17(11-15)27-21-25-14-26-22(28-21)29-12-19(13-29)32-18-7-5-16(23)6-8-18/h2-8,11,14,19H,9-10,12-13H2,1H3,(H,24,30)(H,25,26,27,28)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229702
PNG
(US9334269, 29)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccccc2Cl)c1
Show InChI InChI=1S/C20H19ClN6O2/c1-22-18(28)13-5-4-6-14(9-13)25-19-23-12-24-20(26-19)27-10-15(11-27)29-17-8-3-2-7-16(17)21/h2-9,12,15H,10-11H2,1H3,(H,22,28)(H,23,24,25,26)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229673
PNG
(US9334269, AK)
Show SMILES CNC(=O)c1cccc(Nc2nc(ncc2F)N2CC(C2)Oc2ccc(Cl)cc2F)c1
Show InChI InChI=1S/C21H18ClF2N5O2/c1-25-20(30)12-3-2-4-14(7-12)27-19-17(24)9-26-21(28-19)29-10-15(11-29)31-18-6-5-13(22)8-16(18)23/h2-9,15H,10-11H2,1H3,(H,25,30)(H,26,27,28)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229703
PNG
(US9334269, 30)
Show SMILES CNC(=O)c1cccc(Nc2nccc(n2)N2CC(C2)Oc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C21H20ClN5O2/c1-23-20(28)14-3-2-4-16(11-14)25-21-24-10-9-19(26-21)27-12-18(13-27)29-17-7-5-15(22)6-8-17/h2-11,18H,12-13H2,1H3,(H,23,28)(H,24,25,26)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229640
PNG
(US9334269, 31 | US9334269, D)
Show SMILES CNC(=O)c1cccc(Nc2nccc(n2)N2CC(C2)Oc2ccc(OC)cc2)c1
Show InChI InChI=1S/C22H23N5O3/c1-23-21(28)15-4-3-5-16(12-15)25-22-24-11-10-20(26-22)27-13-19(14-27)30-18-8-6-17(29-2)7-9-18/h3-12,19H,13-14H2,1-2H3,(H,23,28)(H,24,25,26)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229640
PNG
(US9334269, 31 | US9334269, D)
Show SMILES CNC(=O)c1cccc(Nc2nccc(n2)N2CC(C2)Oc2ccc(OC)cc2)c1
Show InChI InChI=1S/C22H23N5O3/c1-23-21(28)15-4-3-5-16(12-15)25-22-24-11-10-20(26-22)27-13-19(14-27)30-18-8-6-17(29-2)7-9-18/h3-12,19H,13-14H2,1-2H3,(H,23,28)(H,24,25,26)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229705
PNG
(US9334269, 32)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(C)cc2Cl)c1
Show InChI InChI=1S/C21H21ClN6O2/c1-13-6-7-18(17(22)8-13)30-16-10-28(11-16)21-25-12-24-20(27-21)26-15-5-3-4-14(9-15)19(29)23-2/h3-9,12,16H,10-11H2,1-2H3,(H,23,29)(H,24,25,26,27)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229706
PNG
(US9334269, 33)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccccc2)c1
Show InChI InChI=1S/C20H20N6O2/c1-21-18(27)14-6-5-7-15(10-14)24-19-22-13-23-20(25-19)26-11-17(12-26)28-16-8-3-2-4-9-16/h2-10,13,17H,11-12H2,1H3,(H,21,27)(H,22,23,24,25)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229708
PNG
(US9334269, 35)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C21H19F3N6O2/c1-25-18(31)13-3-2-4-15(9-13)28-19-26-12-27-20(29-19)30-10-17(11-30)32-16-7-5-14(6-8-16)21(22,23)24/h2-9,12,17H,10-11H2,1H3,(H,25,31)(H,26,27,28,29)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229707
PNG
(US9334269, 34)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CCN(CC2)c2ccc(C)cc2)c1
Show InChI InChI=1S/C22H25N7O/c1-16-6-8-19(9-7-16)28-10-12-29(13-11-28)22-25-15-24-21(27-22)26-18-5-3-4-17(14-18)20(30)23-2/h3-9,14-15H,10-13H2,1-2H3,(H,23,30)(H,24,25,26,27)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229709
PNG
(US9334269, 36)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CCC(CC2)C(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C23H23ClN6O2/c1-25-21(32)17-3-2-4-19(13-17)28-22-26-14-27-23(29-22)30-11-9-16(10-12-30)20(31)15-5-7-18(24)8-6-15/h2-8,13-14,16H,9-12H2,1H3,(H,25,32)(H,26,27,28,29)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229710
PNG
(US9334269, 37)
Show SMILES CNC(=O)c1cc(F)cc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C20H18ClFN6O2/c1-23-18(29)12-6-14(22)8-15(7-12)26-19-24-11-25-20(27-19)28-9-17(10-28)30-16-4-2-13(21)3-5-16/h2-8,11,17H,9-10H2,1H3,(H,23,29)(H,24,25,26,27)
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AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229711
PNG
(US9334269, 38)
Show SMILES COCCNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(F)cc2)c1
Show InChI InChI=1S/C22H23FN6O3/c1-31-10-9-24-20(30)15-3-2-4-17(11-15)27-21-25-14-26-22(28-21)29-12-19(13-29)32-18-7-5-16(23)6-8-18/h2-8,11,14,19H,9-10,12-13H2,1H3,(H,24,30)(H,25,26,27,28)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229712
PNG
(US9334269, 39)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C20H18Cl2N6O2/c1-23-18(29)12-3-2-4-13(7-12)26-19-24-11-25-20(27-19)28-9-15(10-28)30-14-5-6-16(21)17(22)8-14/h2-8,11,15H,9-10H2,1H3,(H,23,29)(H,24,25,26,27)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a 500n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229713
PNG
(US9334269, 40)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(COc3ccc(Cl)cc3)C2)c1
Show InChI InChI=1S/C21H21ClN6O2/c1-23-19(29)15-3-2-4-17(9-15)26-20-24-13-25-21(27-20)28-10-14(11-28)12-30-18-7-5-16(22)6-8-18/h2-9,13-14H,10-12H2,1H3,(H,23,29)(H,24,25,26,27)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229636
PNG
(US9334269, AAA)
Show SMILES CNC(=O)c1cccc(Nc2nccc(n2)N2CC(C2)Oc2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C21H19Cl2N5O2/c1-24-20(29)13-3-2-4-15(9-13)26-21-25-8-7-19(27-21)28-11-16(12-28)30-18-6-5-14(22)10-17(18)23/h2-10,16H,11-12H2,1H3,(H,24,29)(H,25,26,27)
PDB

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UniProtKB/SwissProt

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n/an/a 520n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229714
PNG
(US9334269, 41)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CCc3cc(OCC(F)(F)F)ccc3C2)c1
Show InChI InChI=1S/C22H21F3N6O2/c1-26-19(32)15-3-2-4-17(9-15)29-20-27-13-28-21(30-20)31-8-7-14-10-18(6-5-16(14)11-31)33-12-22(23,24)25/h2-6,9-10,13H,7-8,11-12H2,1H3,(H,26,32)(H,27,28,29,30)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a 520n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229715
PNG
(US9334269, 42)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(cc2)C(C)C)c1
Show InChI InChI=1S/C23H26N6O2/c1-15(2)16-7-9-19(10-8-16)31-20-12-29(13-20)23-26-14-25-22(28-23)27-18-6-4-5-17(11-18)21(30)24-3/h4-11,14-15,20H,12-13H2,1-3H3,(H,24,30)(H,25,26,27,28)
PDB

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n/an/a 570n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229716
PNG
(US9334269, 43)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CCN(CC2)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C22H22F3N7O/c1-26-19(33)15-4-2-6-17(12-15)29-20-27-14-28-21(30-20)32-10-8-31(9-11-32)18-7-3-5-16(13-18)22(23,24)25/h2-7,12-14H,8-11H2,1H3,(H,26,33)(H,27,28,29,30)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 600n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%