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Patent code US9334286

Compile Data Set for Download or QSAR
Found 108 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230937
PNG
(US9334286, 63)
Show SMILES COCc1ncc(-c2ccc(Nc3cc4cc(ccc4cn3)-c3cnn(CC(C)(C)O)c3)c(OC)c2)n1C
Show InChI InChI=1S/C29H32N6O3/c1-29(2,36)18-35-16-23(14-32-35)19-6-7-21-13-30-27(12-22(21)10-19)33-24-9-8-20(11-26(24)38-5)25-15-31-28(17-37-4)34(25)3/h6-16,36H,17-18H2,1-5H3,(H,30,33)
PDB
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230978
PNG
(US9334286, 105)
Show SMILES COc1cc(ccc1Nc1cc2nc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1nncn1C
Show InChI InChI=1S/C25H26N8O2/c1-25(2,34)14-33-13-18(12-28-33)19-7-6-17-11-26-23(10-21(17)29-19)30-20-8-5-16(9-22(20)35-4)24-31-27-15-32(24)3/h5-13,15,34H,14H2,1-4H3,(H,26,30)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM229974
PNG
(US9334286, 2)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC2CC2)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C28H28N6O/c1-18-29-15-26(33(18)2)21-8-9-25(27(11-21)35-3)32-28-12-23-10-20(6-7-22(23)13-30-28)24-14-31-34(17-24)16-19-4-5-19/h6-15,17,19H,4-5,16H2,1-3H3,(H,30,32)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230979
PNG
(US9334286, 106)
Show SMILES COc1cc(ccc1Nc1cc2nc(ccc2cn1)-c1cnn(CC2(O)CCC2)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C28H29N7O2/c1-18-29-15-25(34(18)2)19-5-8-23(26(11-19)37-3)33-27-12-24-20(13-30-27)6-7-22(32-24)21-14-31-35(16-21)17-28(36)9-4-10-28/h5-8,11-16,36H,4,9-10,17H2,1-3H3,(H,30,33)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230938
PNG
(US9334286, 64)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1ncnn1C
Show InChI InChI=1S/C26H27N7O2/c1-26(2,34)15-33-14-21(13-29-33)17-5-6-19-12-27-24(11-20(19)9-17)31-22-8-7-18(10-23(22)35-4)25-28-16-30-32(25)3/h5-14,16,34H,15H2,1-4H3,(H,27,31)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230915
PNG
(US9334286, 41)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1nncn1C
Show InChI InChI=1S/C26H27N7O2/c1-26(2,34)15-33-14-21(13-29-33)17-5-6-19-12-27-24(11-20(19)9-17)30-22-8-7-18(10-23(22)35-4)25-31-28-16-32(25)3/h5-14,16,34H,15H2,1-4H3,(H,27,30)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230969
PNG
(US9334286, 95)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)C(=O)N1CC2(C1)CCOC2
Show InChI InChI=1S/C30H33N5O4/c1-29(2,37)16-35-15-24(14-32-35)20-4-5-22-13-31-27(12-23(22)10-20)33-25-7-6-21(11-26(25)38-3)28(36)34-17-30(18-34)8-9-39-19-30/h4-7,10-15,37H,8-9,16-19H2,1-3H3,(H,31,33)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230976
PNG
(US9334286, 103)
Show SMILES CCOc1cc(ccc1Nc1cc2nc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1nncn1C
Show InChI InChI=1S/C26H28N8O2/c1-5-36-23-10-17(25-32-28-16-33(25)4)6-9-21(23)31-24-11-22-18(12-27-24)7-8-20(30-22)19-13-29-34(14-19)15-26(2,3)35/h6-14,16,35H,5,15H2,1-4H3,(H,27,31)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230905
PNG
(US9334286, 31)
Show SMILES COCCn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3OC)-c3cnc(C)n3CCOC)cc2c1
Show InChI InChI=1S/C29H32N6O3/c1-20-30-18-27(35(20)10-12-37-3)22-7-8-26(28(14-22)38-4)33-29-15-24-13-21(5-6-23(24)16-31-29)25-17-32-34(19-25)9-11-36-2/h5-8,13-19H,9-12H2,1-4H3,(H,31,33)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230924
PNG
(US9334286, 50)
Show SMILES COc1c(Nc2cc3cc(ccc3cn2)-c2cnn(CC(C)(C)O)c2)ccc(-c2cnc(C)n2C)c1F
Show InChI InChI=1S/C28H29FN6O2/c1-17-30-14-24(34(17)4)22-8-9-23(27(37-5)26(22)29)33-25-11-20-10-18(6-7-19(20)12-31-25)21-13-32-35(15-21)16-28(2,3)36/h6-15,36H,16H2,1-5H3,(H,31,33)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230912
PNG
(US9334286, 38)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)O)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C27H28N6O2/c1-17(34)15-33-16-23(13-30-33)19-5-6-21-12-29-27(11-22(21)9-19)31-24-8-7-20(10-26(24)35-4)25-14-28-18(2)32(25)3/h5-14,16-17,34H,15H2,1-4H3,(H,29,31)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230943
PNG
(US9334286, 69)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1cnc(C)n1CC(C)(C)O
Show InChI InChI=1S/C31H36N6O3/c1-20-32-16-27(37(20)19-31(4,5)39)22-9-10-26(28(12-22)40-6)35-29-13-24-11-21(7-8-23(24)14-33-29)25-15-34-36(17-25)18-30(2,3)38/h7-17,38-39H,18-19H2,1-6H3,(H,33,35)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230965
PNG
(US9334286, 91)
Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(CC(C)(C)O)c2)c(OC(F)F)c1
Show InChI InChI=1S/C28H29F2N5O4/c1-28(2,37)16-35-13-21(12-32-35)17-4-5-19-11-31-25(10-20(19)8-17)33-23-7-6-18(9-24(23)39-27(29)30)26(36)34-14-22(15-34)38-3/h4-13,22,27,37H,14-16H2,1-3H3,(H,31,33)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230975
PNG
(US9334286, 102)
Show SMILES COc1cc(ccc1Nc1cc2nc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C27H29N7O2/c1-17-28-14-24(33(17)4)18-6-9-22(25(10-18)36-5)32-26-11-23-19(12-29-26)7-8-21(31-23)20-13-30-34(15-20)16-27(2,3)35/h6-15,35H,16H2,1-5H3,(H,29,32)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230935
PNG
(US9334286, 61)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)C(=O)NCCO
Show InChI InChI=1S/C26H29N5O4/c1-26(2,34)16-31-15-21(14-29-31)17-4-5-19-13-28-24(12-20(19)10-17)30-22-7-6-18(11-23(22)35-3)25(33)27-8-9-32/h4-7,10-15,32,34H,8-9,16H2,1-3H3,(H,27,33)(H,28,30)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230968
PNG
(US9334286, 94)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)C(=O)N1CCC(CC1)C#N
Show InChI InChI=1S/C30H32N6O3/c1-30(2,38)19-36-18-25(17-33-36)21-4-5-23-16-32-28(14-24(23)12-21)34-26-7-6-22(13-27(26)39-3)29(37)35-10-8-20(15-31)9-11-35/h4-7,12-14,16-18,20,38H,8-11,19H2,1-3H3,(H,32,34)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230977
PNG
(US9334286, 104)
Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2cc3nc(ccc3cn2)-c2cnn(CC(C)(C)O)c2)c(OC)c1
Show InChI InChI=1S/C27H30N6O4/c1-27(2,35)16-33-13-19(12-29-33)21-7-6-18-11-28-25(10-23(18)30-21)31-22-8-5-17(9-24(22)37-4)26(34)32-14-20(15-32)36-3/h5-13,20,35H,14-16H2,1-4H3,(H,28,31)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230894
PNG
(US9334286, 20)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(C)c1C)-c1cnc(C)n1C
Show InChI InChI=1S/C26H26N6O/c1-16-22(14-29-32(16)4)18-6-7-20-13-28-26(12-21(20)10-18)30-23-9-8-19(11-25(23)33-5)24-15-27-17(2)31(24)3/h6-15H,1-5H3,(H,28,30)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230970
PNG
(US9334286, 96)
Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cn(CC(C)(C)O)nn2)c(OC)c1
Show InChI InChI=1S/C27H30N6O4/c1-27(2,35)16-33-15-23(30-31-33)17-5-6-19-12-28-25(11-20(19)9-17)29-22-8-7-18(10-24(22)37-4)26(34)32-13-21(14-32)36-3/h5-12,15,21,35H,13-14,16H2,1-4H3,(H,28,29)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230934
PNG
(US9334286, 60)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)C(=O)N(C)C
Show InChI InChI=1S/C26H29N5O3/c1-26(2,33)16-31-15-21(14-28-31)17-6-7-19-13-27-24(12-20(19)10-17)29-22-9-8-18(11-23(22)34-5)25(32)30(3)4/h6-15,33H,16H2,1-5H3,(H,27,29)
PDB
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230940
PNG
(US9334286, 66)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)C(=O)N1CCN(C)CC1
Show InChI InChI=1S/C29H34N6O3/c1-29(2,37)19-35-18-24(17-31-35)20-5-6-22-16-30-27(15-23(22)13-20)32-25-8-7-21(14-26(25)38-4)28(36)34-11-9-33(3)10-12-34/h5-8,13-18,37H,9-12,19H2,1-4H3,(H,30,32)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM229973
PNG
(US9334286, 1)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC2CCOCC2)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C30H32N6O2/c1-20-31-17-28(35(20)2)23-6-7-27(29(13-23)37-3)34-30-14-25-12-22(4-5-24(25)15-32-30)26-16-33-36(19-26)18-21-8-10-38-11-9-21/h4-7,12-17,19,21H,8-11,18H2,1-3H3,(H,32,34)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM229975
PNG
(US9334286, 3)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(F)F)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C26H24F2N6O/c1-16-29-13-23(33(16)2)18-6-7-22(24(9-18)35-3)32-26-10-20-8-17(4-5-19(20)11-30-26)21-12-31-34(14-21)15-25(27)28/h4-14,25H,15H2,1-3H3,(H,30,32)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230904
PNG
(US9334286, 30)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC2(C)COC2)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C29H30N6O2/c1-19-30-14-26(34(19)3)21-7-8-25(27(10-21)36-4)33-28-11-23-9-20(5-6-22(23)12-31-28)24-13-32-35(15-24)16-29(2)17-37-18-29/h5-15H,16-18H2,1-4H3,(H,31,33)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230920
PNG
(US9334286, 46)
Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(CC(C)(C)O)c2)c(OC)c1
Show InChI InChI=1S/C28H31N5O4/c1-28(2,35)17-33-14-22(13-30-33)18-5-6-20-12-29-26(11-21(20)9-18)31-24-8-7-19(10-25(24)37-4)27(34)32-15-23(16-32)36-3/h5-14,23,35H,15-17H2,1-4H3,(H,29,31)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230966
PNG
(US9334286, 92)
Show SMILES CCOc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)C(=O)N1CC(C1)OC
Show InChI InChI=1S/C29H33N5O4/c1-5-38-26-11-20(28(35)33-16-24(17-33)37-4)8-9-25(26)32-27-12-22-10-19(6-7-21(22)13-30-27)23-14-31-34(15-23)18-29(2,3)36/h6-15,24,36H,5,16-18H2,1-4H3,(H,30,32)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230898
PNG
(US9334286, 24)
Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(C)c2)c(OC)c1
Show InChI InChI=1S/C25H25N5O3/c1-29-13-20(12-27-29)16-4-5-18-11-26-24(10-19(18)8-16)28-22-7-6-17(9-23(22)33-3)25(31)30-14-21(15-30)32-2/h4-13,21H,14-15H2,1-3H3,(H,26,28)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230922
PNG
(US9334286, 48)
Show SMILES CCOc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1nncn1C
Show InChI InChI=1S/C27H29N7O2/c1-5-36-24-11-19(26-32-29-17-33(26)4)8-9-23(24)31-25-12-21-10-18(6-7-20(21)13-28-25)22-14-30-34(15-22)16-27(2,3)35/h6-15,17,35H,5,16H2,1-4H3,(H,28,31)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230885
PNG
(US9334286, 11)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1ccc(C)nc1)-c1cnc(C)n1C
Show InChI InChI=1S/C27H25N5O/c1-17-5-6-21(14-28-17)19-7-8-22-15-30-27(13-23(22)11-19)31-24-10-9-20(12-26(24)33-4)25-16-29-18(2)32(25)3/h5-16H,1-4H3,(H,30,31)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230897
PNG
(US9334286, 23)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(C)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C25H24N6O/c1-16-26-14-23(31(16)3)18-7-8-22(24(10-18)32-4)29-25-11-20-9-17(5-6-19(20)12-27-25)21-13-28-30(2)15-21/h5-15H,1-4H3,(H,27,29)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230903
PNG
(US9334286, 29)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C28H30N6O2/c1-18-29-15-25(33(18)4)20-8-9-24(26(11-20)36-5)32-27-12-22-10-19(6-7-21(22)13-30-27)23-14-31-34(16-23)17-28(2,3)35/h6-16,35H,17H2,1-5H3,(H,30,32)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230939
PNG
(US9334286, 65)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)C(=O)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C28H31N5O5S/c1-28(2,35)18-33-17-23(16-30-33)19-4-5-21-15-29-26(14-22(21)12-19)31-24-7-6-20(13-25(24)38-3)27(34)32-8-10-39(36,37)11-9-32/h4-7,12-17,35H,8-11,18H2,1-3H3,(H,29,31)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230944
PNG
(US9334286, 70)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1nnc2CN(C)CCn12
Show InChI InChI=1S/C29H32N8O2/c1-29(2,38)18-36-16-23(15-31-36)19-5-6-21-14-30-26(13-22(21)11-19)32-24-8-7-20(12-25(24)39-4)28-34-33-27-17-35(3)9-10-37(27)28/h5-8,11-16,38H,9-10,17-18H2,1-4H3,(H,30,32)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230902
PNG
(US9334286, 28)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC2CCC2)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C29H30N6O/c1-19-30-16-27(34(19)2)22-9-10-26(28(12-22)36-3)33-29-13-24-11-21(7-8-23(24)14-31-29)25-15-32-35(18-25)17-20-5-4-6-20/h7-16,18,20H,4-6,17H2,1-3H3,(H,31,33)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230906
PNG
(US9334286, 32)
Show SMILES COCCn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3OC)-c3cnc(C)n3CO)cc2c1
Show InChI InChI=1S/C27H28N6O3/c1-18-28-15-25(33(18)17-34)20-6-7-24(26(11-20)36-3)31-27-12-22-10-19(4-5-21(22)13-29-27)23-14-30-32(16-23)8-9-35-2/h4-7,10-16,34H,8-9,17H2,1-3H3,(H,29,31)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230910
PNG
(US9334286, 36)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1cnn(C)c1CO
Show InChI InChI=1S/C28H30N6O3/c1-28(2,36)17-34-15-22(13-31-34)18-5-6-20-12-29-27(11-21(20)9-18)32-24-8-7-19(10-26(24)37-4)23-14-30-33(3)25(23)16-35/h5-15,35-36H,16-17H2,1-4H3,(H,29,32)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230948
PNG
(US9334286, 74)
Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(CC(C)(C)OC)c2)c(OC)c1
Show InChI InChI=1S/C29H33N5O4/c1-29(2,38-5)18-34-15-23(14-31-34)19-6-7-21-13-30-27(12-22(21)10-19)32-25-9-8-20(11-26(25)37-4)28(35)33-16-24(17-33)36-3/h6-15,24H,16-18H2,1-5H3,(H,30,32)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230908
PNG
(US9334286, 34)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(C)c1CO)-c1cnc(C)n1C
Show InChI InChI=1S/C26H26N6O2/c1-16-27-14-23(31(16)2)18-7-8-22(25(10-18)34-4)30-26-11-20-9-17(5-6-19(20)12-28-26)21-13-29-32(3)24(21)15-33/h5-14,33H,15H2,1-4H3,(H,28,30)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230916
PNG
(US9334286, 42)
Show SMILES Cc1ncc(-c2ccc(Nc3cc4cc(ccc4cn3)-c3cnn(CC(C)(C)O)c3)c(Cl)c2)n1C
Show InChI InChI=1S/C27H27ClN6O/c1-17-29-14-25(33(17)4)19-7-8-24(23(28)10-19)32-26-11-21-9-18(5-6-20(21)12-30-26)22-13-31-34(15-22)16-27(2,3)35/h5-15,35H,16H2,1-4H3,(H,30,32)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230954
PNG
(US9334286, 80)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)S(=O)(=O)N(C)C
Show InChI InChI=1S/C25H29N5O4S/c1-25(2,31)16-30-15-20(14-27-30)17-6-7-18-13-26-24(11-19(18)10-17)28-22-9-8-21(12-23(22)34-5)35(32,33)29(3)4/h6-15,31H,16H2,1-5H3,(H,26,28)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230930
PNG
(US9334286, 56)
Show SMILES COc1nc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C27H29N7O2/c1-17-28-14-24(33(17)4)22-8-9-23(26(32-22)36-5)31-25-11-20-10-18(6-7-19(20)12-29-25)21-13-30-34(15-21)16-27(2,3)35/h6-15,35H,16H2,1-5H3,(H,29,31)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230931
PNG
(US9334286, 57)
Show SMILES COc1cc(cnc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C27H29N7O2/c1-17-28-14-23(33(17)4)21-9-24(36-5)26(30-12-21)32-25-10-20-8-18(6-7-19(20)11-29-25)22-13-31-34(15-22)16-27(2,3)35/h6-15,35H,16H2,1-5H3,(H,29,30,32)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230955
PNG
(US9334286, 81)
Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(CC(O)CO)c2)c(OC)c1
Show InChI InChI=1S/C27H29N5O5/c1-36-23-14-31(15-23)27(35)18-5-6-24(25(8-18)37-2)30-26-9-20-7-17(3-4-19(20)10-28-26)21-11-29-32(12-21)13-22(34)16-33/h3-12,22-23,33-34H,13-16H2,1-2H3,(H,28,30)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


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More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230889
PNG
(US9334286, 15)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(c1)C(C)C)-c1cnc(C)n1C
Show InChI InChI=1S/C27H28N6O/c1-17(2)33-16-23(14-30-33)19-6-7-21-13-29-27(12-22(21)10-19)31-24-9-8-20(11-26(24)34-5)25-15-28-18(3)32(25)4/h6-17H,1-5H3,(H,29,31)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230895
PNG
(US9334286, 21)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(C)c1)-c1cncn1C
Show InChI InChI=1S/C24H22N6O/c1-29-15-25-13-22(29)17-6-7-21(23(9-17)31-3)28-24-10-19-8-16(4-5-18(19)11-26-24)20-12-27-30(2)14-20/h4-15H,1-3H3,(H,26,28)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230936
PNG
(US9334286, 62)
Show SMILES COCCNC(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(CC(C)(C)O)c2)c(OC)c1
Show InChI InChI=1S/C27H31N5O4/c1-27(2,34)17-32-16-22(15-30-32)18-5-6-20-14-29-25(13-21(20)11-18)31-23-8-7-19(12-24(23)36-4)26(33)28-9-10-35-3/h5-8,11-16,34H,9-10,17H2,1-4H3,(H,28,33)(H,29,31)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230909
PNG
(US9334286, 35)
Show SMILES COCCn1c(C)ncc1-c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(CC(C)(C)O)c2)c(OC)c1
Show InChI InChI=1S/C30H34N6O3/c1-20-31-17-27(36(20)10-11-38-4)22-8-9-26(28(13-22)39-5)34-29-14-24-12-21(6-7-23(24)15-32-29)25-16-33-35(18-25)19-30(2,3)37/h6-9,12-18,37H,10-11,19H2,1-5H3,(H,32,34)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230946
PNG
(US9334286, 72)
Show SMILES COCCn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3OC)C(=O)N3CC(C3)OC)cc2c1
Show InChI InChI=1S/C27H29N5O4/c1-34-9-8-32-15-22(14-29-32)18-4-5-20-13-28-26(12-21(20)10-18)30-24-7-6-19(11-25(24)36-3)27(33)31-16-23(17-31)35-2/h4-7,10-15,23H,8-9,16-17H2,1-3H3,(H,28,30)
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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230949
PNG
(US9334286, 75)
Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(CC(O)C(F)(F)F)c2)c(OC)c1
Show InChI InChI=1S/C27H26F3N5O4/c1-38-21-13-34(14-21)26(37)17-5-6-22(23(8-17)39-2)33-25-9-19-7-16(3-4-18(19)10-31-25)20-11-32-35(12-20)15-24(36)27(28,29)30/h3-12,21,24,36H,13-15H2,1-2H3,(H,31,33)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230957
PNG
(US9334286, 83)
Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(c2)C2CCCC2O)c(OC)c1
Show InChI InChI=1S/C29H31N5O4/c1-37-23-16-33(17-23)29(36)19-8-9-24(27(11-19)38-2)32-28-12-21-10-18(6-7-20(21)13-30-28)22-14-31-34(15-22)25-4-3-5-26(25)35/h6-15,23,25-26,35H,3-5,16-17H2,1-2H3,(H,30,32)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230890
PNG
(US9334286, 16)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cccnc1)-c1cnc(C)n1C
Show InChI InChI=1S/C26H23N5O/c1-17-28-16-24(31(17)2)19-8-9-23(25(12-19)32-3)30-26-13-22-11-18(6-7-21(22)15-29-26)20-5-4-10-27-14-20/h4-16H,1-3H3,(H,29,30)
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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230929
PNG
(US9334286, 55)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1nnc2CN(CCn12)C(=O)OC(C)(C)C
Show InChI InChI=1S/C33H38N8O4/c1-32(2,3)45-31(42)39-11-12-41-29(19-39)37-38-30(41)22-9-10-26(27(14-22)44-6)36-28-15-24-13-21(7-8-23(24)16-34-28)25-17-35-40(18-25)20-33(4,5)43/h7-10,13-18,43H,11-12,19-20H2,1-6H3,(H,34,36)
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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230907
PNG
(US9334286, 33)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(c1)C1COC1)-c1cnc(C)n1C
Show InChI InChI=1S/C27H26N6O2/c1-17-28-13-25(32(17)2)19-6-7-24(26(9-19)34-3)31-27-10-21-8-18(4-5-20(21)11-29-27)22-12-30-33(14-22)23-15-35-16-23/h4-14,23H,15-16H2,1-3H3,(H,29,31)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230917
PNG
(US9334286, 43)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC2(O)CCC2)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C29H30N6O2/c1-19-30-16-26(34(19)2)21-7-8-25(27(12-21)37-3)33-28-13-23-11-20(5-6-22(23)14-31-28)24-15-32-35(17-24)18-29(36)9-4-10-29/h5-8,11-17,36H,4,9-10,18H2,1-3H3,(H,31,33)
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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230972
PNG
(US9334286, 98)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(C[C@@H](C)O)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C27H28N6O2/c1-17(34)15-33-16-23(13-30-33)19-5-6-21-12-29-27(11-22(21)9-19)31-24-8-7-20(10-26(24)35-4)25-14-28-18(2)32(25)3/h5-14,16-17,34H,15H2,1-4H3,(H,29,31)/t17-/m1/s1
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230974
PNG
(US9334286, 101)
Show SMILES COc1cc(ccc1Nc1cc2nc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1cnn(C)c1
Show InChI InChI=1S/C26H27N7O2/c1-26(2,34)16-33-15-20(13-29-33)21-7-6-18-11-27-25(10-23(18)30-21)31-22-8-5-17(9-24(22)35-4)19-12-28-32(3)14-19/h5-15,34H,16H2,1-4H3,(H,27,31)
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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230926
PNG
(US9334286, 52)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1cnn(C)c1
Show InChI InChI=1S/C27H28N6O2/c1-27(2,34)17-33-16-23(14-30-33)18-5-6-20-12-28-26(11-21(20)9-18)31-24-8-7-19(10-25(24)35-4)22-13-29-32(3)15-22/h5-16,34H,17H2,1-4H3,(H,28,31)
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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230925
PNG
(US9334286, 51)
Show SMILES COCc1c(cnn1C)-c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(CC(C)(C)O)c2)c(OC)c1
Show InChI InChI=1S/C29H32N6O3/c1-29(2,36)18-35-16-23(14-32-35)19-6-7-21-13-30-28(12-22(21)10-19)33-25-9-8-20(11-27(25)38-5)24-15-31-34(3)26(24)17-37-4/h6-16,36H,17-18H2,1-5H3,(H,30,33)
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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230933
PNG
(US9334286, 59)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3Cl)S(C)(=O)=O)cc2c1
Show InChI InChI=1S/C23H23ClN4O3S/c1-23(2,29)14-28-13-18(12-26-28)15-4-5-16-11-25-22(9-17(16)8-15)27-21-7-6-19(10-20(21)24)32(3,30)31/h4-13,29H,14H2,1-3H3,(H,25,27)
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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM229978
PNG
(US9334286, 6)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnco1)-c1cnc(C)n1C
Show InChI InChI=1S/C24H21N5O2/c1-15-26-12-21(29(15)2)16-6-7-20(22(9-16)30-3)28-24-10-19-8-17(23-13-25-14-31-23)4-5-18(19)11-27-24/h4-14H,1-3H3,(H,27,28)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230896
PNG
(US9334286, 22)
Show SMILES Cc1ncc(-c2ccc(Nc3cc4cc(ccc4cn3)-c3cnn(C)c3)c(Cl)c2)n1C
Show InChI InChI=1S/C24H21ClN6/c1-15-26-13-23(31(15)3)17-6-7-22(21(25)9-17)29-24-10-19-8-16(4-5-18(19)11-27-24)20-12-28-30(2)14-20/h4-14H,1-3H3,(H,27,29)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230947
PNG
(US9334286, 73)
Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(CC(O)C(C)C)c2)c(OC)c1
Show InChI InChI=1S/C29H33N5O4/c1-18(2)26(35)17-34-14-23(13-31-34)19-5-6-21-12-30-28(11-22(21)9-19)32-25-8-7-20(10-27(25)38-4)29(36)33-15-24(16-33)37-3/h5-14,18,24,26,35H,15-17H2,1-4H3,(H,30,32)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230901
PNG
(US9334286, 27)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnnn1C)-c1cnc(C)n1C
Show InChI InChI=1S/C24H23N7O/c1-15-25-13-21(30(15)2)17-7-8-20(23(10-17)32-4)28-24-11-19-9-16(5-6-18(19)12-26-24)22-14-27-29-31(22)3/h5-14H,1-4H3,(H,26,28)
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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230918
PNG
(US9334286, 44)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(F)(F)F)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C26H23F3N6O/c1-16-30-13-23(34(16)2)18-6-7-22(24(9-18)36-3)33-25-10-20-8-17(4-5-19(20)11-31-25)21-12-32-35(14-21)15-26(27,28)29/h4-14H,15H2,1-3H3,(H,31,33)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230927
PNG
(US9334286, 53)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1cnn(C)c1C
Show InChI InChI=1S/C28H30N6O2/c1-18-24(15-30-33(18)4)20-8-9-25(26(11-20)36-5)32-27-12-22-10-19(6-7-21(22)13-29-27)23-14-31-34(16-23)17-28(2,3)35/h6-16,35H,17H2,1-5H3,(H,29,32)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230945
PNG
(US9334286, 71)
Show SMILES CCC(O)Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3OC)C(=O)N3CC(C3)OC)cc2c1
Show InChI InChI=1S/C28H31N5O4/c1-4-23(34)15-33-14-22(13-30-33)18-5-6-20-12-29-27(11-21(20)9-18)31-25-8-7-19(10-26(25)37-3)28(35)32-16-24(17-32)36-2/h5-14,23-24,34H,4,15-17H2,1-3H3,(H,29,31)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230883
PNG
(US9334286, 9)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cncs1)-c1cnc(C)n1C
Show InChI InChI=1S/C24H21N5OS/c1-15-26-12-21(29(15)2)16-6-7-20(22(9-16)30-3)28-24-10-19-8-17(23-13-25-14-31-23)4-5-18(19)11-27-24/h4-14H,1-3H3,(H,27,28)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230950
PNG
(US9334286, 76)
Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(c2)C(C)C(C)(C)O)c(OC)c1
Show InChI InChI=1S/C29H33N5O4/c1-18(29(2,3)36)34-15-23(14-31-34)19-6-7-21-13-30-27(12-22(21)10-19)32-25-9-8-20(11-26(25)38-5)28(35)33-16-24(17-33)37-4/h6-15,18,24,36H,16-17H2,1-5H3,(H,30,32)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230967
PNG
(US9334286, 93)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)C(=O)N1CC(F)(F)C1
Show InChI InChI=1S/C27H27F2N5O3/c1-26(2,36)14-34-13-21(12-31-34)17-4-5-19-11-30-24(10-20(19)8-17)32-22-7-6-18(9-23(22)37-3)25(35)33-15-27(28,29)16-33/h4-13,36H,14-16H2,1-3H3,(H,30,32)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM229977
PNG
(US9334286, 5)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnc(C)n1C)-c1cnc(C)n1C
Show InChI InChI=1S/C26H26N6O/c1-16-27-14-23(31(16)3)18-6-7-20-13-29-26(12-21(20)10-18)30-22-9-8-19(11-25(22)33-5)24-15-28-17(2)32(24)4/h6-15H,1-5H3,(H,29,30)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230982
PNG
(US9334286, 99)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(C[C@H](C)O)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C27H28N6O2/c1-17(34)15-33-16-23(13-30-33)19-5-6-21-12-29-27(11-22(21)9-19)31-24-8-7-20(10-26(24)35-4)25-14-28-18(2)32(25)3/h5-14,16-17,34H,15H2,1-4H3,(H,29,31)/t17-/m0/s1
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230956
PNG
(US9334286, 82)
Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(c2)C2COCC2O)c(OC)c1
Show InChI InChI=1S/C28H29N5O5/c1-36-22-13-32(14-22)28(35)18-5-6-23(26(8-18)37-2)31-27-9-20-7-17(3-4-19(20)10-29-27)21-11-30-33(12-21)24-15-38-16-25(24)34/h3-12,22,24-25,34H,13-16H2,1-2H3,(H,29,31)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230964
PNG
(US9334286, 90)
Show SMILES CNC(=O)c1ccc2cnc(Nc3ccc(cc3OC)-c3cnc(C)n3C)cc2c1
Show InChI InChI=1S/C23H23N5O2/c1-14-25-13-20(28(14)3)15-7-8-19(21(10-15)30-4)27-22-11-18-9-16(23(29)24-2)5-6-17(18)12-26-22/h5-13H,1-4H3,(H,24,29)(H,26,27)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230911
PNG
(US9334286, 37)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC2COC2)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C28H28N6O2/c1-18-29-13-26(33(18)2)21-6-7-25(27(9-21)35-3)32-28-10-23-8-20(4-5-22(23)11-30-28)24-12-31-34(15-24)14-19-16-36-17-19/h4-13,15,19H,14,16-17H2,1-3H3,(H,30,32)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230941
PNG
(US9334286, 67)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C30H36N6O3/c1-30(2,38)19-36-18-24(17-32-36)20-5-6-22-16-31-28(15-23(22)13-20)34-26-8-7-21(14-27(26)39-4)29(37)33-25-9-11-35(3)12-10-25/h5-8,13-18,25,38H,9-12,19H2,1-4H3,(H,31,34)(H,33,37)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230932
PNG
(US9334286, 58)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3Cl)-c3cncnc3)cc2c1
Show InChI InChI=1S/C26H23ClN6O/c1-26(2,34)15-33-14-22(13-31-33)17-3-4-19-12-30-25(9-20(19)7-17)32-24-6-5-18(8-23(24)27)21-10-28-16-29-11-21/h3-14,16,34H,15H2,1-2H3,(H,30,32)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230958
PNG
(US9334286, 84)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)-c1cnc(C#N)n1C
Show InChI InChI=1S/C28H27N7O2/c1-28(2,36)17-35-16-22(14-32-35)18-5-6-20-13-30-26(11-21(20)9-18)33-23-8-7-19(10-25(23)37-4)24-15-31-27(12-29)34(24)3/h5-11,13-16,36H,17H2,1-4H3,(H,30,33)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230913
PNG
(US9334286, 39)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(c1)C1CCOCC1)-c1cnc(C)n1C
Show InChI InChI=1S/C29H30N6O2/c1-19-30-17-27(34(19)2)21-6-7-26(28(13-21)36-3)33-29-14-23-12-20(4-5-22(23)15-31-29)24-16-32-35(18-24)25-8-10-37-11-9-25/h4-7,12-18,25H,8-11H2,1-3H3,(H,31,33)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230973
PNG
(US9334286, 100)
Show SMILES COc1cc(ccc1Nc1cc2nc(ccc2cn1)-c1cnn(C)c1)-c1cnn(C)c1
Show InChI InChI=1S/C23H21N7O/c1-29-13-17(11-25-29)15-4-7-20(22(8-15)31-3)28-23-9-21-16(10-24-23)5-6-19(27-21)18-12-26-30(2)14-18/h4-14H,1-3H3,(H,24,28)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230942
PNG
(US9334286, 68)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(c1)C(C)C(C)(C)O)-c1cnc(C)n1C
Show InChI InChI=1S/C29H32N6O2/c1-18(29(3,4)36)35-17-24(15-32-35)20-7-8-22-14-31-28(13-23(22)11-20)33-25-10-9-21(12-27(25)37-6)26-16-30-19(2)34(26)5/h7-18,36H,1-6H3,(H,31,33)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230914
PNG
(US9334286, 40)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC2COC(C)(C)O2)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C30H32N6O3/c1-19-31-15-27(35(19)4)21-8-9-26(28(11-21)37-5)34-29-12-23-10-20(6-7-22(23)13-32-29)24-14-33-36(16-24)17-25-18-38-30(2,3)39-25/h6-16,25H,17-18H2,1-5H3,(H,32,34)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230921
PNG
(US9334286, 47)
Show SMILES Cc1ncc(-c2ccc(Nc3cc4cc(ccc4cn3)-c3cnn(CC(C)(C)O)c3)cc2)n1C
Show InChI InChI=1S/C27H28N6O/c1-18-28-15-25(32(18)4)19-7-9-24(10-8-19)31-26-12-22-11-20(5-6-21(22)13-29-26)23-14-30-33(16-23)17-27(2,3)34/h5-16,34H,17H2,1-4H3,(H,29,31)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230884
PNG
(US9334286, 10)
Show SMILES CCn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3OC)-c3cnc(C)n3C)cc2c1
Show InChI InChI=1S/C26H26N6O/c1-5-32-16-22(14-29-32)18-6-7-20-13-28-26(12-21(20)10-18)30-23-9-8-19(11-25(23)33-4)24-15-27-17(2)31(24)3/h6-16H,5H2,1-4H3,(H,28,30)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230960
PNG
(US9334286, 86)
Show SMILES COCC1CN(C1)C(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(CC(C)(C)O)c2)c(OC)c1
Show InChI InChI=1S/C29H33N5O4/c1-29(2,36)18-34-16-24(13-31-34)20-5-6-22-12-30-27(11-23(22)9-20)32-25-8-7-21(10-26(25)38-4)28(35)33-14-19(15-33)17-37-3/h5-13,16,19,36H,14-15,17-18H2,1-4H3,(H,30,32)
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Cancer Research Technology Limited

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Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230962
PNG
(US9334286, 88)
Show SMILES CCOc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC2(O)CCC2)c1)-c1nncn1C
Show InChI InChI=1S/C28H29N7O2/c1-3-37-25-12-20(27-33-30-18-34(27)2)7-8-24(25)32-26-13-22-11-19(5-6-21(22)14-29-26)23-15-31-35(16-23)17-28(36)9-4-10-28/h5-8,11-16,18,36H,3-4,9-10,17H2,1-2H3,(H,29,32)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230980
PNG
(US9334286, 107 | US9334286, 108)
Show SMILES COc1cc(ccc1Nc1cc2nc(ccc2cn1)C(=O)N(C)C)-c1cnn(C)c1
Show InChI InChI=1S/C22H22N6O2/c1-27(2)22(29)18-8-6-15-11-23-21(10-19(15)25-18)26-17-7-5-14(9-20(17)30-4)16-12-24-28(3)13-16/h5-13H,1-4H3,(H,23,26)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230961
PNG
(US9334286, 87)
Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(CC3(O)CCC3)c2)c(OC)c1
Show InChI InChI=1S/C29H31N5O4/c1-37-24-16-33(17-24)28(35)20-6-7-25(26(11-20)38-2)32-27-12-22-10-19(4-5-21(22)13-30-27)23-14-31-34(15-23)18-29(36)8-3-9-29/h4-7,10-15,24,36H,3,8-9,16-18H2,1-2H3,(H,30,32)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230971
PNG
(US9334286, 97)
Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(CC(C)(C)O)n2)c(OC)c1
Show InChI InChI=1S/C27H30N6O4/c1-27(2,35)16-33-29-13-23(31-33)17-5-6-19-12-28-25(11-20(19)9-17)30-22-8-7-18(10-24(22)37-4)26(34)32-14-21(15-32)36-3/h5-13,21,35H,14-16H2,1-4H3,(H,28,30)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230953
PNG
(US9334286, 79)
Show SMILES COCC(Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3OC)C(=O)N3CC(C3)OC)cc2c1)OC
Show InChI InChI=1S/C29H33N5O5/c1-36-18-25(38-3)17-34-14-23(13-31-34)19-5-6-21-12-30-28(11-22(21)9-19)32-26-8-7-20(10-27(26)39-4)29(35)33-15-24(16-33)37-2/h5-14,24-25H,15-18H2,1-4H3,(H,30,32)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230900
PNG
(US9334286, 26)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cncc(C)c1)-c1cnc(C)n1C
Show InChI InChI=1S/C27H25N5O/c1-17-9-23(14-28-13-17)19-5-6-21-15-30-27(12-22(21)10-19)31-24-8-7-20(11-26(24)33-4)25-16-29-18(2)32(25)3/h5-16H,1-4H3,(H,30,31)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230923
PNG
(US9334286, 49)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1)C#N
Show InChI InChI=1S/C24H23N5O2/c1-24(2,30)15-29-14-20(13-27-29)17-5-6-18-12-26-23(10-19(18)9-17)28-21-7-4-16(11-25)8-22(21)31-3/h4-10,12-14,30H,15H2,1-3H3,(H,26,28)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230891
PNG
(US9334286, 17)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cncnc1)-c1cnc(C)n1C
Show InChI InChI=1S/C25H22N6O/c1-16-28-14-23(31(16)2)18-6-7-22(24(9-18)32-3)30-25-10-20-8-17(4-5-19(20)13-29-25)21-11-26-15-27-12-21/h4-15H,1-3H3,(H,29,30)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230959
PNG
(US9334286, 85)
Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(c2)C2CCCCC2O)c(OC)c1
Show InChI InChI=1S/C30H33N5O4/c1-38-24-17-34(18-24)30(37)20-9-10-25(28(12-20)39-2)33-29-13-22-11-19(7-8-21(22)14-31-29)23-15-32-35(16-23)26-5-3-4-6-27(26)36/h7-16,24,26-27,36H,3-6,17-18H2,1-2H3,(H,31,33)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230952
PNG
(US9334286, 78)
Show SMILES COCC(O)Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3OC)C(=O)N3CC(C3)OC)cc2c1
Show InChI InChI=1S/C28H31N5O5/c1-36-17-23(34)14-33-13-22(12-30-33)18-4-5-20-11-29-27(10-21(20)8-18)31-25-7-6-19(9-26(25)38-3)28(35)32-15-24(16-32)37-2/h4-13,23-24,34H,14-17H2,1-3H3,(H,29,31)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230888
PNG
(US9334286, 14)
Show SMILES COCCn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3OC)-c3cnc(C)n3C)cc2c1
Show InChI InChI=1S/C27H28N6O2/c1-18-28-16-25(32(18)2)20-7-8-24(26(12-20)35-4)31-27-13-22-11-19(5-6-21(22)14-29-27)23-15-30-33(17-23)9-10-34-3/h5-8,11-17H,9-10H2,1-4H3,(H,29,31)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230951
PNG
(US9334286, 77)
Show SMILES Cc1nnc(o1)-c1ccc(Nc2cc3cc(ccc3cn2)-c2cnn(CC(C)(C)O)c2)c(Cl)c1
Show InChI InChI=1S/C25H23ClN6O2/c1-15-30-31-24(34-15)17-6-7-22(21(26)9-17)29-23-10-19-8-16(4-5-18(19)11-27-23)20-12-28-32(13-20)14-25(2,3)33/h4-13,33H,14H2,1-3H3,(H,27,29)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230899
PNG
(US9334286, 25)
Show SMILES COCCn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3OC)-c3cnc(CO)n3C)cc2c1
Show InChI InChI=1S/C27H28N6O3/c1-32-24(15-29-27(32)17-34)19-6-7-23(25(11-19)36-3)31-26-12-21-10-18(4-5-20(21)13-28-26)22-14-30-33(16-22)8-9-35-2/h4-7,10-16,34H,8-9,17H2,1-3H3,(H,28,31)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230893
PNG
(US9334286, 19)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cn(C)nc1C)-c1cnc(C)n1C
Show InChI InChI=1S/C26H26N6O/c1-16-22(15-31(3)30-16)18-6-7-20-13-28-26(12-21(20)10-18)29-23-9-8-19(11-25(23)33-5)24-14-27-17(2)32(24)4/h6-15H,1-5H3,(H,28,29)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230919
PNG
(US9334286, 45)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3Cl)N3CCOCC3)cc2c1
Show InChI InChI=1S/C26H28ClN5O2/c1-26(2,33)17-32-16-21(15-29-32)18-3-4-19-14-28-25(12-20(19)11-18)30-24-6-5-22(13-23(24)27)31-7-9-34-10-8-31/h3-6,11-16,33H,7-10,17H2,1-2H3,(H,28,30)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230928
PNG
(US9334286, 54)
Show SMILES COc1cc(F)ccc1Nc1cc2cc(ccc2cn1)-c1cnn(CC(C)(C)O)c1
Show InChI InChI=1S/C23H23FN4O2/c1-23(2,29)14-28-13-18(12-26-28)15-4-5-16-11-25-22(9-17(16)8-15)27-20-7-6-19(24)10-21(20)30-3/h4-13,29H,14H2,1-3H3,(H,25,27)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230887
PNG
(US9334286, 13)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1sc(C)nc1C)-c1cnc(C)n1C
Show InChI InChI=1S/C26H25N5OS/c1-15-26(33-17(3)29-15)19-6-7-20-13-28-25(12-21(20)10-19)30-22-9-8-18(11-24(22)32-5)23-14-27-16(2)31(23)4/h6-14H,1-5H3,(H,28,30)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230882
PNG
(US9334286, 8)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1ccc(nc1)N(C)C)-c1cnc(C)n1C
Show InChI InChI=1S/C28H28N6O/c1-18-29-17-25(34(18)4)20-8-10-24(26(13-20)35-5)32-27-14-23-12-19(6-7-22(23)15-30-27)21-9-11-28(31-16-21)33(2)3/h6-17H,1-5H3,(H,30,32)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM229976
PNG
(US9334286, 4)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1cnn(c1)C1CCN(CC1)C(=O)OC(C)(C)C)-c1cnc(C)n1C
Show InChI InChI=1S/C34H39N7O3/c1-22-35-20-30(39(22)5)24-9-10-29(31(16-24)43-6)38-32-17-26-15-23(7-8-25(26)18-36-32)27-19-37-41(21-27)28-11-13-40(14-12-28)33(42)44-34(2,3)4/h7-10,15-21,28H,11-14H2,1-6H3,(H,36,38)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230892
PNG
(US9334286, 18)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)C1CC1)-c1cnc(C)n1C
Show InChI InChI=1S/C24H24N4O/c1-15-25-14-22(28(15)2)18-8-9-21(23(11-18)29-3)27-24-12-20-10-17(16-4-5-16)6-7-19(20)13-26-24/h6-14,16H,4-5H2,1-3H3,(H,26,27)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM229979
PNG
(US9334286, 7)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1ccncc1)-c1cnc(C)n1C
Show InChI InChI=1S/C26H23N5O/c1-17-28-16-24(31(17)2)20-6-7-23(25(13-20)32-3)30-26-14-22-12-19(4-5-21(22)15-29-26)18-8-10-27-11-9-18/h4-16H,1-3H3,(H,29,30)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230980
PNG
(US9334286, 107 | US9334286, 108)
Show SMILES COc1cc(ccc1Nc1cc2nc(ccc2cn1)C(=O)N(C)C)-c1cnn(C)c1
Show InChI InChI=1S/C22H22N6O2/c1-27(2)22(29)18-8-6-15-11-23-21(10-19(15)25-18)26-17-7-5-14(9-20(17)30-4)16-12-24-28(3)13-16/h5-13H,1-4H3,(H,23,26)
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Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230963
PNG
(US9334286, 89)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)C(=O)N(C)C)-c1cnc(C)n1C
Show InChI InChI=1S/C24H25N5O2/c1-15-25-14-21(29(15)4)16-8-9-20(22(11-16)31-5)27-23-12-19-10-17(24(30)28(2)3)6-7-18(19)13-26-23/h6-14H,1-5H3,(H,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 472n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM230886
PNG
(US9334286, 12)
Show SMILES COc1cc(ccc1Nc1cc2cc(ccc2cn1)-c1ccc(nc1)N(C)C(=O)OC(C)(C)C)-c1cnc(C)n1C
Show InChI InChI=1S/C32H34N6O3/c1-20-33-19-27(37(20)5)22-10-12-26(28(15-22)40-7)36-29-16-25-14-21(8-9-24(25)17-34-29)23-11-13-30(35-18-23)38(6)31(39)41-32(2,3)4/h8-19H,1-7H3,(H,34,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 713n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%