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Patent code US9340500

Compile Data Set for Download or QSAR
Found 154 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230228
PNG
(US9340500, I-072)
Show SMILES Cc1c(cc(C2CCCCC2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H34F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h5,9-10,17-18,20H,2-4,6-8,11-16H2,1H3,(H,30,33)
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21n/a 45n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230231
PNG
(US9340500, I-075)
Show SMILES Cc1c(cc(C2CCN(CC2)C(=O)OCc2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C33H39F3N4O4/c1-24-29(31(41)37-28-10-5-9-27(21-28)33(34,35)36)22-30(40(24)14-6-13-38-17-19-43-20-18-38)26-11-15-39(16-12-26)32(42)44-23-25-7-3-2-4-8-25/h2-5,7-10,21-22,26H,6,11-20,23H2,1H3,(H,37,41)
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130n/a 270n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230252
PNG
(US9340500, I-096)
Show SMILES CNC(C)CCn1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H30F3N3O/c1-14(26-6)10-11-28-15(2)18(13-19(28)21(3,4)5)20(29)27-17-9-7-8-16(12-17)22(23,24)25/h7-9,12-14,26H,10-11H2,1-6H3,(H,27,29)
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130n/a 420n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230253
PNG
(US9340500, I-097)
Show SMILES CC(CCn1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H34F3N3O2/c1-17(30-11-13-33-14-12-30)9-10-31-18(2)21(16-22(31)24(3,4)5)23(32)29-20-8-6-7-19(15-20)25(26,27)28/h6-8,15-17H,9-14H2,1-5H3,(H,29,32)
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130n/a 430n/an/an/an/an/an/a



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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230229
PNG
(US9340500, I-073)
Show SMILES Cc1c(cc(-c2ccccn2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O2/c1-18-21(24(33)30-20-7-4-6-19(16-20)25(26,27)28)17-23(22-8-2-3-9-29-22)32(18)11-5-10-31-12-14-34-15-13-31/h2-4,6-9,16-17H,5,10-15H2,1H3,(H,30,33)
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160n/a 340n/an/an/an/an/an/a



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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230187
PNG
(US9340500, I-031)
Show SMILES CNCCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N3O/c1-16-20(22(30)28-19-11-6-10-18(14-19)23(24,25)26)15-21(17-8-4-3-5-9-17)29(16)13-7-12-27-2/h3-6,8-11,14-15,27H,7,12-13H2,1-2H3,(H,28,30)
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Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230174
PNG
(US9340500, I-018)
Show SMILES CN(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H26F3N3O/c1-17-21(23(31)28-20-12-7-11-19(15-20)24(25,26)27)16-22(18-9-5-4-6-10-18)30(17)14-8-13-29(2)3/h4-7,9-12,15-16H,8,13-14H2,1-3H3,(H,28,31)
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Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230264
PNG
(US9340500, I-108)
Show SMILES Cc1c(cc(n1CC(C)(C)CN1CCOCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H36F3N3O2/c1-18-21(23(33)30-20-9-7-8-19(14-20)26(27,28)29)15-22(24(2,3)4)32(18)17-25(5,6)16-31-10-12-34-13-11-31/h7-9,14-15H,10-13,16-17H2,1-6H3,(H,30,33)
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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230172
PNG
(US9340500, I-016)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN(CCO)CCO)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H30F3N3O3/c1-19-23(25(35)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31(13-15-33)14-16-34/h2-5,7-10,17-18,33-34H,6,11-16H2,1H3,(H,30,35)
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Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230227
PNG
(US9340500, I-071)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCNC(=O)C1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H27F3N4O2/c1-18-22(25(35)31-21-10-5-9-20(15-21)26(27,28)29)16-23(19-7-3-2-4-8-19)33(18)13-6-12-32-14-11-30-24(34)17-32/h2-5,7-10,15-16H,6,11-14,17H2,1H3,(H,30,34)(H,31,35)
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Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230158
PNG
(US9340500, I-002)
Show SMILES Cc1c(cc(n1CCCN1CCOCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H32F3N3O2/c1-17-20(22(31)28-19-8-5-7-18(15-19)24(25,26)27)16-21(23(2,3)4)30(17)10-6-9-29-11-13-32-14-12-29/h5,7-8,15-16H,6,9-14H2,1-4H3,(H,28,31)
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Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230278
PNG
(US9340500, I-122)
Show SMILES Cc1c(cc(n1CC(F)(F)CN1CCOCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H30F5N3O2/c1-16-19(21(33)30-18-7-5-6-17(12-18)24(27,28)29)13-20(22(2,3)4)32(16)15-23(25,26)14-31-8-10-34-11-9-31/h5-7,12-13H,8-11,14-15H2,1-4H3,(H,30,33)
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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230219
PNG
(US9340500, I-063)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1ccno1
Show InChI InChI=1S/C27H25F3N4O3/c1-18-22(25(35)32-21-11-6-10-20(16-21)27(28,29)30)17-23(19-8-4-3-5-9-19)34(18)15-7-14-33(2)26(36)24-12-13-31-37-24/h3-6,8-13,16-17H,7,14-15H2,1-2H3,(H,32,35)
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Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230195
PNG
(US9340500, I-039)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)CC1CCN(C)CC1
Show InChI InChI=1S/C30H37F3N4O/c1-22-27(29(38)34-26-12-7-11-25(19-26)30(31,32)33)20-28(24-9-5-4-6-10-24)37(22)16-8-15-36(3)21-23-13-17-35(2)18-14-23/h4-7,9-12,19-20,23H,8,13-18,21H2,1-3H3,(H,34,38)
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Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230256
PNG
(US9340500, I-100)
Show SMILES CNCC(C)(C)Cn1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H32F3N3O/c1-15-18(20(30)28-17-10-8-9-16(11-17)23(24,25)26)12-19(21(2,3)4)29(15)14-22(5,6)13-27-7/h8-12,27H,13-14H2,1-7H3,(H,28,30)
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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230243
PNG
(US9340500, I-087)
Show SMILES Cc1c(nc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O2/c1-18-22(24(33)29-21-10-5-9-20(17-21)25(26,27)28)30-23(19-7-3-2-4-8-19)32(18)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17H,6,11-16H2,1H3,(H,29,33)
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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230203
PNG
(US9340500, I-047)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1ccncc1
Show InChI InChI=1S/C29H27F3N4O2/c1-20-25(27(37)34-24-11-6-10-23(18-24)29(30,31)32)19-26(21-8-4-3-5-9-21)36(20)17-7-16-35(2)28(38)22-12-14-33-15-13-22/h3-6,8-15,18-19H,7,16-17H2,1-2H3,(H,34,37)
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Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230164
PNG
(US9340500, I-008)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCCCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H30F3N3O/c1-20-24(26(34)31-23-13-8-12-22(18-23)27(28,29)30)19-25(21-10-4-2-5-11-21)33(20)17-9-16-32-14-6-3-7-15-32/h2,4-5,8,10-13,18-19H,3,6-7,9,14-17H2,1H3,(H,31,34)
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Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230194
PNG
(US9340500, I-038)
Show SMILES CN(C)CC(C)(C)CN(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H39F3N4O/c1-22-26(28(38)34-25-15-10-14-24(18-25)30(31,32)33)19-27(23-12-8-7-9-13-23)37(22)17-11-16-36(6)21-29(2,3)20-35(4)5/h7-10,12-15,18-19H,11,16-17,20-21H2,1-6H3,(H,34,38)
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Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230170
PNG
(US9340500, I-014)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCNCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H29F3N4O/c1-19-23(25(34)31-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)33(19)14-6-13-32-15-11-30-12-16-32/h2-5,7-10,17-18,30H,6,11-16H2,1H3,(H,31,34)
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Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230177
PNG
(US9340500, I-021)
Show SMILES Cc1c(cc(-c2cccnc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O2/c1-18-22(24(33)30-21-7-2-6-20(15-21)25(26,27)28)16-23(19-5-3-8-29-17-19)32(18)10-4-9-31-11-13-34-14-12-31/h2-3,5-8,15-17H,4,9-14H2,1H3,(H,30,33)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230251
PNG
(US9340500, I-095)
Show SMILES Cc1c(cc(n1CCS(=O)(=O)N1CCOCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H30F3N3O4S/c1-16-19(21(30)27-18-7-5-6-17(14-18)23(24,25)26)15-20(22(2,3)4)29(16)10-13-34(31,32)28-8-11-33-12-9-28/h5-7,14-15H,8-13H2,1-4H3,(H,27,30)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230246
PNG
(US9340500, I-090)
Show SMILES CCOC(=O)CCn1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H27F3N2O3/c1-6-30-19(28)10-11-27-14(2)17(13-18(27)21(3,4)5)20(29)26-16-9-7-8-15(12-16)22(23,24)25/h7-9,12-13H,6,10-11H2,1-5H3,(H,26,29)
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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230205
PNG
(US9340500, I-049)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)C1CCCC1
Show InChI InChI=1S/C29H32F3N3O2/c1-20-25(27(36)33-24-15-8-14-23(18-24)29(30,31)32)19-26(21-10-4-3-5-11-21)35(20)17-9-16-34(2)28(37)22-12-6-7-13-22/h3-5,8,10-11,14-15,18-19,22H,6-7,9,12-13,16-17H2,1-2H3,(H,33,36)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230182
PNG
(US9340500, I-026)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCNS(C)(=O)=O)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N3O3S/c1-16-20(22(30)28-19-11-6-10-18(14-19)23(24,25)26)15-21(17-8-4-3-5-9-17)29(16)13-7-12-27-33(2,31)32/h3-6,8-11,14-15,27H,7,12-13H2,1-2H3,(H,28,30)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230239
PNG
(US9340500, I-083)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H26F3N3O2/c1-18-22(24(32)29-21-9-5-8-20(16-21)25(26,27)28)17-23(19-6-3-2-4-7-19)31(18)11-10-30-12-14-33-15-13-30/h2-9,16-17H,10-15H2,1H3,(H,29,32)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230279
PNG
(US9340500, I-123)
Show SMILES Cc1c(cc(n1CC(C)(C)CN1CCNCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H37F3N4O/c1-18-21(23(34)31-20-9-7-8-19(14-20)26(27,28)29)15-22(24(2,3)4)33(18)17-25(5,6)16-32-12-10-30-11-13-32/h7-9,14-15,30H,10-13,16-17H2,1-6H3,(H,31,34)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230277
PNG
(US9340500, I-121)
Show SMILES CNCC(F)(F)Cn1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H26F5N3O/c1-13-16(18(30)28-15-8-6-7-14(9-15)21(24,25)26)10-17(19(2,3)4)29(13)12-20(22,23)11-27-5/h6-10,27H,11-12H2,1-5H3,(H,28,30)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230169
PNG
(US9340500, I-013)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C25H28ClN3O2/c1-19-23(25(30)27-22-10-5-9-21(26)17-22)18-24(20-7-3-2-4-8-20)29(19)12-6-11-28-13-15-31-16-14-28/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,27,30)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230215
PNG
(US9340500, I-059)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)C1CCC1
Show InChI InChI=1S/C28H30F3N3O2/c1-19-24(26(35)32-23-14-7-13-22(17-23)28(29,30)31)18-25(20-9-4-3-5-10-20)34(19)16-8-15-33(2)27(36)21-11-6-12-21/h3-5,7,9-10,13-14,17-18,21H,6,8,11-12,15-16H2,1-2H3,(H,32,35)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230185
PNG
(US9340500, I-029)
Show SMILES CC(C)c1cccc(NC(=O)c2cc(-c3ccccc3)n(CCCN3CCOCC3)c2C)c1
Show InChI InChI=1S/C28H35N3O2/c1-21(2)24-11-7-12-25(19-24)29-28(32)26-20-27(23-9-5-4-6-10-23)31(22(26)3)14-8-13-30-15-17-33-18-16-30/h4-7,9-12,19-21H,8,13-18H2,1-3H3,(H,29,32)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230249
PNG
(US9340500, I-093)
Show SMILES Cc1c(cc(n1CCC(=O)N1CCNCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H31F3N4O2/c1-16-19(22(33)29-18-7-5-6-17(14-18)24(25,26)27)15-20(23(2,3)4)31(16)11-8-21(32)30-12-9-28-10-13-30/h5-7,14-15,28H,8-13H2,1-4H3,(H,29,33)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230247
PNG
(US9340500, I-091)
Show SMILES Cc1c(cc(n1CCC(=O)N1CCOCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H30F3N3O3/c1-16-19(22(32)28-18-7-5-6-17(14-18)24(25,26)27)15-20(23(2,3)4)30(16)9-8-21(31)29-10-12-33-13-11-29/h5-7,14-15H,8-13H2,1-4H3,(H,28,32)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230212
PNG
(US9340500, I-056)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C32H31F3N4O3/c1-21-28(30(41)37-27-12-7-11-25(19-27)32(33,34)35)20-29(23-9-5-4-6-10-23)39(21)18-8-17-38(3)31(42)24-13-15-26(16-14-24)36-22(2)40/h4-7,9-16,19-20H,8,17-18H2,1-3H3,(H,36,40)(H,37,41)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230241
PNG
(US9340500, I-085)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2cc(nn2CCCN2CCOCC2)-c2ccccc2)c1
Show InChI InChI=1S/C24H25F3N4O2/c25-24(26,27)19-8-4-9-20(16-19)28-23(32)22-17-21(18-6-2-1-3-7-18)29-31(22)11-5-10-30-12-14-33-15-13-30/h1-4,6-9,16-17H,5,10-15H2,(H,28,32)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230254
PNG
(US9340500, I-098)
Show SMILES Cc1c(cc(n1CCS(=O)(=O)N1CCNCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H31F3N4O3S/c1-16-19(21(31)28-18-7-5-6-17(14-18)23(24,25)26)15-20(22(2,3)4)30(16)12-13-34(32,33)29-10-8-27-9-11-29/h5-7,14-15,27H,8-13H2,1-4H3,(H,28,31)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230207
PNG
(US9340500, I-051)
Show SMILES CC(C)C(=O)N(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H30F3N3O2/c1-18(2)26(35)32(4)14-9-15-33-19(3)23(17-24(33)20-10-6-5-7-11-20)25(34)31-22-13-8-12-21(16-22)27(28,29)30/h5-8,10-13,16-18H,9,14-15H2,1-4H3,(H,31,34)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230179
PNG
(US9340500, I-023)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N3O/c1-15-19(21(29)27-18-10-5-9-17(13-18)22(23,24)25)14-20(28(15)12-6-11-26)16-7-3-2-4-8-16/h2-5,7-10,13-14H,6,11-12,26H2,1H3,(H,27,29)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230189
PNG
(US9340500, I-033)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)CC1CC1
Show InChI InChI=1S/C27H30F3N3O/c1-19-24(26(34)31-23-11-6-10-22(16-23)27(28,29)30)17-25(21-8-4-3-5-9-21)33(19)15-7-14-32(2)18-20-12-13-20/h3-6,8-11,16-17,20H,7,12-15,18H2,1-2H3,(H,31,34)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230222
PNG
(US9340500, I-066)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1cnc2ccccc2n1
Show InChI InChI=1S/C32H28F3N5O2/c1-21-25(30(41)37-24-13-8-12-23(18-24)32(33,34)35)19-29(22-10-4-3-5-11-22)40(21)17-9-16-39(2)31(42)28-20-36-26-14-6-7-15-27(26)38-28/h3-8,10-15,18-20H,9,16-17H2,1-2H3,(H,37,41)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230165
PNG
(US9340500, I-009)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C25H29N3O2/c1-20-23(25(29)26-22-11-6-3-7-12-22)19-24(21-9-4-2-5-10-21)28(20)14-8-13-27-15-17-30-18-16-27/h2-7,9-12,19H,8,13-18H2,1H3,(H,26,29)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230186
PNG
(US9340500, I-030)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C28H32F3N3O3/c1-19-23(25(35)32-22-14-9-13-21(17-22)28(29,30)31)18-24(20-11-7-6-8-12-20)34(19)16-10-15-33(5)26(36)37-27(2,3)4/h6-9,11-14,17-18H,10,15-16H2,1-5H3,(H,32,35)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230208
PNG
(US9340500, I-052)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C27H28F3N3O2/c1-18-23(25(34)31-22-11-6-10-21(16-22)27(28,29)30)17-24(19-8-4-3-5-9-19)33(18)15-7-14-32(2)26(35)20-12-13-20/h3-6,8-11,16-17,20H,7,12-15H2,1-2H3,(H,31,34)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230220
PNG
(US9340500, I-064)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)C(Cl)(Cl)Cl
Show InChI InChI=1S/C25H23Cl3F3N3O2/c1-16-20(22(35)32-19-11-6-10-18(14-19)25(29,30)31)15-21(17-8-4-3-5-9-17)34(16)13-7-12-33(2)23(36)24(26,27)28/h3-6,8-11,14-15H,7,12-13H2,1-2H3,(H,32,35)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230166
PNG
(US9340500, I-010)
Show SMILES COCCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N2O2/c1-16-20(22(29)27-19-11-6-10-18(14-19)23(24,25)26)15-21(17-8-4-3-5-9-17)28(16)12-7-13-30-2/h3-6,8-11,14-15H,7,12-13H2,1-2H3,(H,27,29)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230180
PNG
(US9340500, I-024)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-8-21(9-11-22)26(27,28)29)18-24(20-6-3-2-4-7-20)32(19)13-5-12-31-14-16-34-17-15-31/h2-4,6-11,18H,5,12-17H2,1H3,(H,30,33)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230191
PNG
(US9340500, I-035)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)CC[C@H](O)[C@H](O)CO
Show InChI InChI=1S/C28H34F3N3O4/c1-19-23(27(38)32-22-11-6-10-21(16-22)28(29,30)31)17-24(20-8-4-3-5-9-20)34(19)14-7-13-33(2)15-12-25(36)26(37)18-35/h3-6,8-11,16-17,25-26,35-37H,7,12-15,18H2,1-2H3,(H,32,38)/t25-,26+/m0/s1
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230230
PNG
(US9340500, I-074)
Show SMILES Cc1c(cc(-c2ccncc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O2/c1-18-22(24(33)30-21-5-2-4-20(16-21)25(26,27)28)17-23(19-6-8-29-9-7-19)32(18)11-3-10-31-12-14-34-15-13-31/h2,4-9,16-17H,3,10-15H2,1H3,(H,30,33)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230225
PNG
(US9340500, I-069)
Show SMILES CN(C)c1cccc(c1)C(=O)N(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C32H33F3N4O2/c1-22-28(30(40)36-26-15-9-14-25(20-26)32(33,34)35)21-29(23-11-6-5-7-12-23)39(22)18-10-17-38(4)31(41)24-13-8-16-27(19-24)37(2)3/h5-9,11-16,19-21H,10,17-18H2,1-4H3,(H,36,40)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230200
PNG
(US9340500, I-044)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1cccs1
Show InChI InChI=1S/C28H26F3N3O2S/c1-19-23(26(35)32-22-12-6-11-21(17-22)28(29,30)31)18-24(20-9-4-3-5-10-20)34(19)15-8-14-33(2)27(36)25-13-7-16-37-25/h3-7,9-13,16-18H,8,14-15H2,1-2H3,(H,32,35)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230221
PNG
(US9340500, I-065)
Show SMILES COc1ccc(OC)c(CC(=O)N(C)CCCn2c(C)c(cc2-c2ccccc2)C(=O)Nc2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C33H34F3N3O4/c1-22-28(32(41)37-26-13-8-12-25(20-26)33(34,35)36)21-29(23-10-6-5-7-11-23)39(22)17-9-16-38(2)31(40)19-24-18-27(42-3)14-15-30(24)43-4/h5-8,10-15,18,20-21H,9,16-17,19H2,1-4H3,(H,37,41)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230183
PNG
(US9340500, I-027)
Show SMILES COC(=O)NCCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N3O3/c1-16-20(22(31)29-19-11-6-10-18(14-19)24(25,26)27)15-21(17-8-4-3-5-9-17)30(16)13-7-12-28-23(32)33-2/h3-6,8-11,14-15H,7,12-13H2,1-2H3,(H,28,32)(H,29,31)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230209
PNG
(US9340500, I-053)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1cccnc1
Show InChI InChI=1S/C29H27F3N4O2/c1-20-25(27(37)34-24-13-6-12-23(17-24)29(30,31)32)18-26(21-9-4-3-5-10-21)36(20)16-8-15-35(2)28(38)22-11-7-14-33-19-22/h3-7,9-14,17-19H,8,15-16H2,1-2H3,(H,34,37)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230211
PNG
(US9340500, I-055)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1ccc2ccccc2n1
Show InChI InChI=1S/C33H29F3N4O2/c1-22-27(31(41)37-26-14-8-13-25(20-26)33(34,35)36)21-30(24-11-4-3-5-12-24)40(22)19-9-18-39(2)32(42)29-17-16-23-10-6-7-15-28(23)38-29/h3-8,10-17,20-21H,9,18-19H2,1-2H3,(H,37,41)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230197
PNG
(US9340500, I-041)
Show SMILES COC(=O)CCCN(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H32F3N3O3/c1-20-24(27(36)32-23-13-7-12-22(18-23)28(29,30)31)19-25(21-10-5-4-6-11-21)34(20)17-9-16-33(2)15-8-14-26(35)37-3/h4-7,10-13,18-19H,8-9,14-17H2,1-3H3,(H,32,36)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230176
PNG
(US9340500, I-020)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1nc2ccccc2s1
Show InChI InChI=1S/C26H28N4O2S/c1-19-21(25(31)28-26-27-22-10-5-6-11-24(22)33-26)18-23(20-8-3-2-4-9-20)30(19)13-7-12-29-14-16-32-17-15-29/h2-6,8-11,18H,7,12-17H2,1H3,(H,27,28,31)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230192
PNG
(US9340500, I-036)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)CC1CCOC1
Show InChI InChI=1S/C28H32F3N3O2/c1-20-25(27(35)32-24-11-6-10-23(16-24)28(29,30)31)17-26(22-8-4-3-5-9-22)34(20)14-7-13-33(2)18-21-12-15-36-19-21/h3-6,8-11,16-17,21H,7,12-15,18-19H2,1-2H3,(H,32,35)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230224
PNG
(US9340500, I-068)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)C1CCOCC1
Show InChI InChI=1S/C29H32F3N3O3/c1-20-25(27(36)33-24-11-6-10-23(18-24)29(30,31)32)19-26(21-8-4-3-5-9-21)35(20)15-7-14-34(2)28(37)22-12-16-38-17-13-22/h3-6,8-11,18-19,22H,7,12-17H2,1-2H3,(H,33,36)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230162
PNG
(US9340500, I-006)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCO)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H21F3N2O2/c1-15-19(21(29)26-18-10-5-9-17(13-18)22(23,24)25)14-20(27(15)11-6-12-28)16-7-3-2-4-8-16/h2-5,7-10,13-14,28H,6,11-12H2,1H3,(H,26,29)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230276
PNG
(US9340500, I-120)
Show SMILES CN([C@H]1CC[C@H](CC1)n1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C25H34F3N3O3S/c1-16-21(23(32)29-18-9-7-8-17(14-18)25(26,27)28)15-22(24(2,3)4)31(16)20-12-10-19(11-13-20)30(5)35(6,33)34/h7-9,14-15,19-20H,10-13H2,1-6H3,(H,29,32)/t19-,20+
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230198
PNG
(US9340500, I-042)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)C1CCCCC1
Show InChI InChI=1S/C30H34F3N3O2/c1-21-26(28(37)34-25-16-9-15-24(19-25)30(31,32)33)20-27(22-11-5-3-6-12-22)36(21)18-10-17-35(2)29(38)23-13-7-4-8-14-23/h3,5-6,9,11-12,15-16,19-20,23H,4,7-8,10,13-14,17-18H2,1-2H3,(H,34,37)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230181
PNG
(US9340500, I-025)
Show SMILES CC(=O)NCCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N3O2/c1-16-21(23(32)29-20-11-6-10-19(14-20)24(25,26)27)15-22(18-8-4-3-5-9-18)30(16)13-7-12-28-17(2)31/h3-6,8-11,14-15H,7,12-13H2,1-2H3,(H,28,31)(H,29,32)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230196
PNG
(US9340500, I-040)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)CC1CCOCC1
Show InChI InChI=1S/C29H34F3N3O2/c1-21-26(28(36)33-25-11-6-10-24(18-25)29(30,31)32)19-27(23-8-4-3-5-9-23)35(21)15-7-14-34(2)20-22-12-16-37-17-13-22/h3-6,8-11,18-19,22H,7,12-17,20H2,1-2H3,(H,33,36)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230206
PNG
(US9340500, I-050)
Show SMILES COCCOCC(=O)N(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H32F3N3O4/c1-20-24(27(36)32-23-12-7-11-22(17-23)28(29,30)31)18-25(21-9-5-4-6-10-21)34(20)14-8-13-33(2)26(35)19-38-16-15-37-3/h4-7,9-12,17-18H,8,13-16,19H2,1-3H3,(H,32,36)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230168
PNG
(US9340500, I-012)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C29H28F3N3O/c1-21-26(28(36)33-24-14-9-13-23(19-24)29(30,31)32)20-27(22-11-5-3-6-12-22)35(21)18-10-17-34(2)25-15-7-4-8-16-25/h3-9,11-16,19-20H,10,17-18H2,1-2H3,(H,33,36)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230210
PNG
(US9340500, I-054)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1ccccn1
Show InChI InChI=1S/C29H27F3N4O2/c1-20-24(27(37)34-23-13-8-12-22(18-23)29(30,31)32)19-26(21-10-4-3-5-11-21)36(20)17-9-16-35(2)28(38)25-14-6-7-15-33-25/h3-8,10-15,18-19H,9,16-17H2,1-2H3,(H,34,37)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230262
PNG
(US9340500, I-106)
Show SMILES CN1CCC(CC1)n1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H30F3N3O/c1-15-19(21(30)27-17-8-6-7-16(13-17)23(24,25)26)14-20(22(2,3)4)29(15)18-9-11-28(5)12-10-18/h6-8,13-14,18H,9-12H2,1-5H3,(H,27,30)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230204
PNG
(US9340500, I-048)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C31H28F3N3O4/c1-20-25(29(38)35-24-11-6-10-23(17-24)31(32,33)34)18-26(21-8-4-3-5-9-21)37(20)15-7-14-36(2)30(39)22-12-13-27-28(16-22)41-19-40-27/h3-6,8-13,16-18H,7,14-15,19H2,1-2H3,(H,35,38)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230216
PNG
(US9340500, I-060)
Show SMILES CN(C)c1ccc(cc1)C(=O)N(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C32H33F3N4O2/c1-22-28(30(40)36-26-13-8-12-25(20-26)32(33,34)35)21-29(23-10-6-5-7-11-23)39(22)19-9-18-38(4)31(41)24-14-16-27(17-15-24)37(2)3/h5-8,10-17,20-21H,9,18-19H2,1-4H3,(H,36,40)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230199
PNG
(US9340500, I-043)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1ccco1
Show InChI InChI=1S/C28H26F3N3O3/c1-19-23(26(35)32-22-12-6-11-21(17-22)28(29,30)31)18-24(20-9-4-3-5-10-20)34(19)15-8-14-33(2)27(36)25-13-7-16-37-25/h3-7,9-13,16-18H,8,14-15H2,1-2H3,(H,32,35)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230218
PNG
(US9340500, I-062)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1csc(n1)-c1cccs1
Show InChI InChI=1S/C31H27F3N4O2S2/c1-20-24(28(39)35-23-12-6-11-22(17-23)31(32,33)34)18-26(21-9-4-3-5-10-21)38(20)15-8-14-37(2)30(40)25-19-42-29(36-25)27-13-7-16-41-27/h3-7,9-13,16-19H,8,14-15H2,1-2H3,(H,35,39)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230171
PNG
(US9340500, I-015)
Show SMILES CC(=O)N1CCN(CCCn2c(C)c(cc2-c2ccccc2)C(=O)Nc2cccc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C28H31F3N4O2/c1-20-25(27(37)32-24-11-6-10-23(18-24)28(29,30)31)19-26(22-8-4-3-5-9-22)35(20)13-7-12-33-14-16-34(17-15-33)21(2)36/h3-6,8-11,18-19H,7,12-17H2,1-2H3,(H,32,37)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230238
PNG
(US9340500, I-082)
Show SMILES Cc1c(NC(=O)c2cccc(c2)C(F)(F)F)cc(-c2ccccc2)n1CCCN1CCOCC1
Show InChI InChI=1S/C26H28F3N3O2/c1-19-23(30-25(33)21-9-5-10-22(17-21)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230163
PNG
(US9340500, I-007)
Show SMILES Cc1c(ccn1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H24F3N3O2/c1-15-18(6-9-26(15)8-3-7-25-10-12-28-13-11-25)19(27)24-17-5-2-4-16(14-17)20(21,22)23/h2,4-6,9,14H,3,7-8,10-13H2,1H3,(H,24,27)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230175
PNG
(US9340500, I-019)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1nccs1
Show InChI InChI=1S/C22H26N4O2S/c1-17-19(21(27)24-22-23-8-15-29-22)16-20(18-6-3-2-4-7-18)26(17)10-5-9-25-11-13-28-14-12-25/h2-4,6-8,15-16H,5,9-14H2,1H3,(H,23,24,27)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230267
PNG
(US9340500, I-111)
Show SMILES Cc1c(cc(n1[C@H]1CC[C@H](N)CC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H30F3N3O/c1-14-19(21(30)28-17-7-5-6-15(12-17)23(24,25)26)13-20(22(2,3)4)29(14)18-10-8-16(27)9-11-18/h5-7,12-13,16,18H,8-11,27H2,1-4H3,(H,28,30)/t16-,18-
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230258
PNG
(US9340500, I-102)
Show SMILES Cc1c(cc(n1C1CCN(CC1)S(C)(=O)=O)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H30F3N3O3S/c1-15-19(21(30)27-17-8-6-7-16(13-17)23(24,25)26)14-20(22(2,3)4)29(15)18-9-11-28(12-10-18)33(5,31)32/h6-8,13-14,18H,9-12H2,1-5H3,(H,27,30)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230272
PNG
(US9340500, I-116)
Show SMILES Cc1c(cc(n1[C@@H]1CC[C@H](N)CC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H30F3N3O/c1-14-19(21(30)28-17-7-5-6-15(12-17)23(24,25)26)13-20(22(2,3)4)29(14)18-10-8-16(27)9-11-18/h5-7,12-13,16,18H,8-11,27H2,1-4H3,(H,28,30)/t16-,18+
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230268
PNG
(US9340500, I-112)
Show SMILES CN[C@H]1CC[C@@H](CC1)n1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H32F3N3O/c1-15-20(22(31)29-18-8-6-7-16(13-18)24(25,26)27)14-21(23(2,3)4)30(15)19-11-9-17(28-5)10-12-19/h6-8,13-14,17,19,28H,9-12H2,1-5H3,(H,29,31)/t17-,19-
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230269
PNG
(US9340500, I-113)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)n1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H34F3N3O/c1-16-21(23(32)29-18-9-7-8-17(14-18)25(26,27)28)15-22(24(2,3)4)31(16)20-12-10-19(11-13-20)30(5)6/h7-9,14-15,19-20H,10-13H2,1-6H3,(H,29,32)/t19-,20-
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230173
PNG
(US9340500, I-017)
Show SMILES Cc1cc(C(=O)Nc2cccc(c2)C(F)(F)F)c(C)n1CCCN1CCOCC1
Show InChI InChI=1S/C21H26F3N3O2/c1-15-13-19(16(2)27(15)8-4-7-26-9-11-29-12-10-26)20(28)25-18-6-3-5-17(14-18)21(22,23)24/h3,5-6,13-14H,4,7-12H2,1-2H3,(H,25,28)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230160
PNG
(US9340500, I-004)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C24H27ClN4O2/c1-18-21(24(30)27-23-9-8-20(25)17-26-23)16-22(19-6-3-2-4-7-19)29(18)11-5-10-28-12-14-31-15-13-28/h2-4,6-9,16-17H,5,10-15H2,1H3,(H,26,27,30)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230242
PNG
(US9340500, I-086)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2cc(-c3ccccc3)n(CCCN3CCOCC3)n2)c1
Show InChI InChI=1S/C24H25F3N4O2/c25-24(26,27)19-8-4-9-20(16-19)28-23(32)21-17-22(18-6-2-1-3-7-18)31(29-21)11-5-10-30-12-14-33-15-13-30/h1-4,6-9,16-17H,5,10-15H2,(H,28,32)
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1.60E+3n/a 3.40E+3n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230271
PNG
(US9340500, I-115)
Show SMILES Cc1c(cc(n1[C@@H]1CC[C@@H](CC1)NS(C)(=O)=O)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H32F3N3O3S/c1-15-20(22(31)28-18-8-6-7-16(13-18)24(25,26)27)14-21(23(2,3)4)30(15)19-11-9-17(10-12-19)29-34(5,32)33/h6-8,13-14,17,19,29H,9-12H2,1-5H3,(H,28,31)/t17-,19+
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1.60E+3n/a 6.00E+3n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230237
PNG
(US9340500, I-081)
Show SMILES Cc1c(NC(=O)Nc2cccc(c2)C(F)(F)F)cc(-c2ccccc2)n1CCCN1CCOCC1
Show InChI InChI=1S/C26H29F3N4O2/c1-19-23(31-25(34)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)33(19)12-6-11-32-13-15-35-16-14-32/h2-5,7-10,17-18H,6,11-16H2,1H3,(H2,30,31,34)
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1.61E+3n/an/an/an/an/an/an/an/a



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Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230188
PNG
(US9340500, I-032)
Show SMILES CC(C)CN(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H32F3N3O/c1-19(2)18-32(4)14-9-15-33-20(3)24(17-25(33)21-10-6-5-7-11-21)26(34)31-23-13-8-12-22(16-23)27(28,29)30/h5-8,10-13,16-17,19H,9,14-15,18H2,1-4H3,(H,31,34)
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Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230214
PNG
(US9340500, I-058)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1ccc2occc2c1
Show InChI InChI=1S/C32H28F3N3O3/c1-21-27(30(39)36-26-11-6-10-25(19-26)32(33,34)35)20-28(22-8-4-3-5-9-22)38(21)16-7-15-37(2)31(40)24-12-13-29-23(18-24)14-17-41-29/h3-6,8-14,17-20H,7,15-16H2,1-2H3,(H,36,39)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230202
PNG
(US9340500, I-046)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)Cc1cccs1
Show InChI InChI=1S/C29H28F3N3O2S/c1-20-25(28(37)33-23-12-6-11-22(17-23)29(30,31)32)19-26(21-9-4-3-5-10-21)35(20)15-8-14-34(2)27(36)18-24-13-7-16-38-24/h3-7,9-13,16-17,19H,8,14-15,18H2,1-2H3,(H,33,37)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230226
PNG
(US9340500, I-070)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(C)=O
Show InChI InChI=1S/C25H26F3N3O2/c1-17-22(24(33)29-21-12-7-11-20(15-21)25(26,27)28)16-23(19-9-5-4-6-10-19)31(17)14-8-13-30(3)18(2)32/h4-7,9-12,15-16H,8,13-14H2,1-3H3,(H,29,33)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230167
PNG
(US9340500, I-011)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCNc1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H26F3N3O/c1-20-25(27(35)33-24-15-8-12-22(18-24)28(29,30)31)19-26(21-10-4-2-5-11-21)34(20)17-9-16-32-23-13-6-3-7-14-23/h2-8,10-15,18-19,32H,9,16-17H2,1H3,(H,33,35)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230217
PNG
(US9340500, I-061)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C33H29F3N4O2S/c1-22-27(30(41)37-26-16-9-15-25(19-26)33(34,35)36)20-29(23-11-5-3-6-12-23)40(22)18-10-17-39(2)32(42)28-21-43-31(38-28)24-13-7-4-8-14-24/h3-9,11-16,19-21H,10,17-18H2,1-2H3,(H,37,41)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230161
PNG
(US9340500, I-005)
Show SMILES CCOC(=O)Cc1csc(NC(=O)c2cc(-c3ccccc3)n(CCCN3CCOCC3)c2C)n1
Show InChI InChI=1S/C26H32N4O4S/c1-3-34-24(31)16-21-18-35-26(27-21)28-25(32)22-17-23(20-8-5-4-6-9-20)30(19(22)2)11-7-10-29-12-14-33-15-13-29/h4-6,8-9,17-18H,3,7,10-16H2,1-2H3,(H,27,28,32)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230184
PNG
(US9340500, I-028)
Show SMILES FC(F)(F)c1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H25F6N3O2/c27-25(28,29)19-8-4-9-20(16-19)33-24(36)21-17-22(18-6-2-1-3-7-18)35(23(21)26(30,31)32)11-5-10-34-12-14-37-15-13-34/h1-4,6-9,16-17H,5,10-15H2,(H,33,36)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230201
PNG
(US9340500, I-045)
Show SMILES COCC(=O)N(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H28F3N3O3/c1-18-22(25(34)30-21-12-7-11-20(15-21)26(27,28)29)16-23(19-9-5-4-6-10-19)32(18)14-8-13-31(2)24(33)17-35-3/h4-7,9-12,15-16H,8,13-14,17H2,1-3H3,(H,30,34)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230213
PNG
(US9340500, I-057)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)C1CCN(CC1)C(C)=O
Show InChI InChI=1S/C31H35F3N4O3/c1-21-27(29(40)35-26-12-7-11-25(19-26)31(32,33)34)20-28(23-9-5-4-6-10-23)38(21)16-8-15-36(3)30(41)24-13-17-37(18-14-24)22(2)39/h4-7,9-12,19-20,24H,8,13-18H2,1-3H3,(H,35,40)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230275
PNG
(US9340500, I-119)
Show SMILES CN[C@H]1CC[C@H](CC1)n1c(C)c(cc1C(C)(C)C)S(=O)(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H32F3N3O2S/c1-15-20(32(30,31)28-18-8-6-7-16(13-18)23(24,25)26)14-21(22(2,3)4)29(15)19-11-9-17(27-5)10-12-19/h6-8,13-14,17,19,27-28H,9-12H2,1-5H3/t17-,19+
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230236
PNG
(US9340500, I-080)
Show SMILES Cc1c(NS(=O)(=O)c2cccc(c2)C(F)(F)F)cc(-c2ccccc2)n1CCCN1CCOCC1
Show InChI InChI=1S/C25H28F3N3O3S/c1-19-23(29-35(32,33)22-10-5-9-21(17-22)25(26,27)28)18-24(20-7-3-2-4-8-20)31(19)12-6-11-30-13-15-34-16-14-30/h2-5,7-10,17-18,29H,6,11-16H2,1H3
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230193
PNG
(US9340500, I-037)
Show SMILES CCOC(=O)C1CC1CN(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H34F3N3O3/c1-4-39-29(38)26-16-22(26)19-35(3)14-9-15-36-20(2)25(18-27(36)21-10-6-5-7-11-21)28(37)34-24-13-8-12-23(17-24)30(31,32)33/h5-8,10-13,17-18,22,26H,4,9,14-16,19H2,1-3H3,(H,34,37)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230233
PNG
(US9340500, I-077)
Show SMILES CC(=O)N1CCC(CC1)c1cc(C(=O)Nc2cccc(c2)C(F)(F)F)c(C)n1CCCN1CCOCC1
Show InChI InChI=1S/C27H35F3N4O3/c1-19-24(26(36)31-23-6-3-5-22(17-23)27(28,29)30)18-25(21-7-11-33(12-8-21)20(2)35)34(19)10-4-9-32-13-15-37-16-14-32/h3,5-6,17-18,21H,4,7-16H2,1-2H3,(H,31,36)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230234
PNG
(US9340500, I-078)
Show SMILES Cc1c(cc(C2CCN(CC2)S(C)(=O)=O)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H35F3N4O4S/c1-19-23(25(34)30-22-6-3-5-21(17-22)26(27,28)29)18-24(20-7-11-32(12-8-20)38(2,35)36)33(19)10-4-9-31-13-15-37-16-14-31/h3,5-6,17-18,20H,4,7-16H2,1-2H3,(H,30,34)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230255
PNG
(US9340500, I-099)
Show SMILES Cc1c(cc(n1C1CCNCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H28F3N3O/c1-14-18(20(29)27-16-7-5-6-15(12-16)22(23,24)25)13-19(21(2,3)4)28(14)17-8-10-26-11-9-17/h5-7,12-13,17,26H,8-11H2,1-4H3,(H,27,29)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230263
PNG
(US9340500, I-107)
Show SMILES COC(=O)CN1CCC(CC1)n1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H32F3N3O3/c1-16-20(23(33)29-18-8-6-7-17(13-18)25(26,27)28)14-21(24(2,3)4)31(16)19-9-11-30(12-10-19)15-22(32)34-5/h6-8,13-14,19H,9-12,15H2,1-5H3,(H,29,33)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230250
PNG
(US9340500, I-094)
Show SMILES CNS(=O)(=O)CCn1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H26F3N3O3S/c1-13-16(18(27)25-15-8-6-7-14(11-15)20(21,22)23)12-17(19(2,3)4)26(13)9-10-30(28,29)24-5/h6-8,11-12,24H,9-10H2,1-5H3,(H,25,27)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230265
PNG
(US9340500, I-109)
Show SMILES Cc1c(cc(n1C1CCN(CC1)C1CCNCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H37F3N4O/c1-18-23(25(35)32-20-7-5-6-19(16-20)27(28,29)30)17-24(26(2,3)4)34(18)22-10-14-33(15-11-22)21-8-12-31-13-9-21/h5-7,16-17,21-22,31H,8-15H2,1-4H3,(H,32,35)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230270
PNG
(US9340500, I-114)
Show SMILES Cc1c(cc(n1[C@H]1CC[C@@H](CC1)NS(C)(=O)=O)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H32F3N3O3S/c1-15-20(22(31)28-18-8-6-7-16(13-18)24(25,26)27)14-21(23(2,3)4)30(15)19-11-9-17(10-12-19)29-34(5,32)33/h6-8,13-14,17,19,29H,9-12H2,1-5H3,(H,28,31)/t17-,19-
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230223
PNG
(US9340500, I-067)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)C(=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C33H29F3N4O3/c1-21-26(31(42)38-24-13-8-12-23(18-24)33(34,35)36)19-29(22-10-4-3-5-11-22)40(21)17-9-16-39(2)32(43)30(41)27-20-37-28-15-7-6-14-25(27)28/h3-8,10-15,18-20,37H,9,16-17H2,1-2H3,(H,38,42)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230248
PNG
(US9340500, I-092)
Show SMILES CNC(=O)CCn1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H26F3N3O2/c1-13-16(12-17(20(2,3)4)27(13)10-9-18(28)25-5)19(29)26-15-8-6-7-14(11-15)21(22,23)24/h6-8,11-12H,9-10H2,1-5H3,(H,25,28)(H,26,29)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230266
PNG
(US9340500, I-110)
Show SMILES Cc1c(cc(n1C1CCN(CCO)CC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H32F3N3O2/c1-16-20(22(32)28-18-7-5-6-17(14-18)24(25,26)27)15-21(23(2,3)4)30(16)19-8-10-29(11-9-19)12-13-31/h5-7,14-15,19,31H,8-13H2,1-4H3,(H,28,32)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230259
PNG
(US9340500, I-103)
Show SMILES CNCCCn1c(C)c(cc1C(C)(C)C)S(=O)(=O)NCc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H30F3N3O2S/c1-15-18(13-19(20(2,3)4)27(15)11-7-10-25-5)30(28,29)26-14-16-8-6-9-17(12-16)21(22,23)24/h6,8-9,12-13,25-26H,7,10-11,14H2,1-5H3
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230178
PNG
(US9340500, I-022)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H28F3N3O2/c1-19-21(25(33)30-23-11-6-5-10-22(23)26(27,28)29)18-24(20-8-3-2-4-9-20)32(19)13-7-12-31-14-16-34-17-15-31/h2-6,8-11,18H,7,12-17H2,1H3,(H,30,33)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230274
PNG
(US9340500, I-118)
Show SMILES Cc1c(cc(n1CCCN1CCOCC1)C(C)(C)C)S(=O)(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H32F3N3O3S/c1-17-20(33(30,31)27-19-8-5-7-18(15-19)23(24,25)26)16-21(22(2,3)4)29(17)10-6-9-28-11-13-32-14-12-28/h5,7-8,15-16,27H,6,9-14H2,1-4H3
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230273
PNG
(US9340500, I-117)
Show SMILES CNCCCn1c(C)c(cc1C(C)(C)C)S(=O)(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H28F3N3O2S/c1-14-17(13-18(19(2,3)4)26(14)11-7-10-24-5)29(27,28)25-16-9-6-8-15(12-16)20(21,22)23/h6,8-9,12-13,24-25H,7,10-11H2,1-5H3
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230257
PNG
(US9340500, I-101)
Show SMILES CC(=O)N1CCC(CC1)n1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H30F3N3O2/c1-15-20(22(32)28-18-8-6-7-17(13-18)24(25,26)27)14-21(23(3,4)5)30(15)19-9-11-29(12-10-19)16(2)31/h6-8,13-14,19H,9-12H2,1-5H3,(H,28,32)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230190
PNG
(US9340500, I-034)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)CCOCc1ccccc1
Show InChI InChI=1S/C32H34F3N3O2/c1-24-29(31(39)36-28-16-9-15-27(21-28)32(33,34)35)22-30(26-13-7-4-8-14-26)38(24)18-10-17-37(2)19-20-40-23-25-11-5-3-6-12-25/h3-9,11-16,21-22H,10,17-20,23H2,1-2H3,(H,36,39)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230260
PNG
(US9340500, I-104)
Show SMILES Cc1c(cc(n1CCCN1CCOCC1)C(C)(C)C)S(=O)(=O)NCc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H34F3N3O3S/c1-18-21(34(31,32)28-17-19-7-5-8-20(15-19)24(25,26)27)16-22(23(2,3)4)30(18)10-6-9-29-11-13-33-14-12-29/h5,7-8,15-16,28H,6,9-14,17H2,1-4H3
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230244
PNG
(US9340500, I-088)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2cnc(c(CCCN3CCOCC3)c2)-c2ccccc2)c1
Show InChI InChI=1S/C26H26F3N3O2/c27-26(28,29)22-9-4-10-23(17-22)31-25(33)21-16-20(8-5-11-32-12-14-34-15-13-32)24(30-18-21)19-6-2-1-3-7-19/h1-4,6-7,9-10,16-18H,5,8,11-15H2,(H,31,33)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230159
PNG
(US9340500, I-003)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cnccn1
Show InChI InChI=1S/C23H27N5O2/c1-18-20(23(29)26-22-17-24-8-9-25-22)16-21(19-6-3-2-4-7-19)28(18)11-5-10-27-12-14-30-15-13-27/h2-4,6-9,16-17H,5,10-15H2,1H3,(H,25,26,29)
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230261
PNG
(US9340500, I-105)
Show SMILES Cc1c(cc(n1CCCN1CCNCC1)C(C)(C)C)S(=O)(=O)NCc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H35F3N4O2S/c1-18-21(34(32,33)29-17-19-7-5-8-20(15-19)24(25,26)27)16-22(23(2,3)4)31(18)12-6-11-30-13-9-28-10-14-30/h5,7-8,15-16,28-29H,6,9-14,17H2,1-4H3
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230235
PNG
(US9340500, I-079)
Show SMILES Cc1c(cc(C#N)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H23F3N4O2/c1-15-19(20(29)26-17-5-2-4-16(12-17)21(22,23)24)13-18(14-25)28(15)7-3-6-27-8-10-30-11-9-27/h2,4-5,12-13H,3,6-11H2,1H3,(H,26,29)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230245
PNG
(US9340500, I-089)
Show SMILES FC(F)(F)c1cccc(Nc2ccc3C(CCCN4CCOCC4)[N](=Cc3c2)c2ccccc2)c1
Show InChI InChI=1S/C28H29F3N3O/c29-28(30,31)22-6-4-7-23(19-22)32-24-11-12-26-21(18-24)20-34(25-8-2-1-3-9-25)27(26)10-5-13-33-14-16-35-17-15-33/h1-4,6-9,11-12,18-20,27,32H,5,10,13-17H2
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230157
PNG
(US9340500, I-001)
Show SMILES Cc1c(cc(n1CCCN1CCOCC1)C(C)(C)C)C(=O)OCc1ccccc1
Show InChI InChI=1S/C24H34N2O3/c1-19-21(23(27)29-18-20-9-6-5-7-10-20)17-22(24(2,3)4)26(19)12-8-11-25-13-15-28-16-14-25/h5-7,9-10,17H,8,11-16,18H2,1-4H3
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Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230232
PNG
(US9340500, I-076)
Show SMILES Cc1c(cc(C2CCNCC2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H33F3N4O2/c1-18-22(24(33)30-21-5-2-4-20(16-21)25(26,27)28)17-23(19-6-8-29-9-7-19)32(18)11-3-10-31-12-14-34-15-13-31/h2,4-5,16-17,19,29H,3,6-15H2,1H3,(H,30,33)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230164
PNG
(US9340500, I-008)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCCCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H30F3N3O/c1-20-24(26(34)31-23-13-8-12-22(18-23)27(28,29)30)19-25(21-10-4-2-5-11-21)33(20)17-9-16-32-14-6-3-7-15-32/h2,4-5,8,10-13,18-19H,3,6-7,9,14-17H2,1H3,(H,31,34)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230172
PNG
(US9340500, I-016)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN(CCO)CCO)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H30F3N3O3/c1-19-23(25(35)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31(13-15-33)14-16-34/h2-5,7-10,17-18,33-34H,6,11-16H2,1H3,(H,30,35)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230205
PNG
(US9340500, I-049)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)C1CCCC1
Show InChI InChI=1S/C29H32F3N3O2/c1-20-25(27(36)33-24-15-8-14-23(18-24)29(30,31)32)19-26(21-10-4-3-5-11-21)35(20)17-9-16-34(2)28(37)22-12-6-7-13-22/h3-5,8,10-11,14-15,18-19,22H,6-7,9,12-13,16-17H2,1-2H3,(H,33,36)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230280
PNG
(US9340500, I-124)
Show SMILES CC(CCn1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F)N1CCNCC1
Show InChI InChI=1S/C25H35F3N4O/c1-17(31-13-10-29-11-14-31)9-12-32-18(2)21(16-22(32)24(3,4)5)23(33)30-20-8-6-7-19(15-20)25(26,27)28/h6-8,15-17,29H,9-14H2,1-5H3,(H,30,33)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230227
PNG
(US9340500, I-071)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCNC(=O)C1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H27F3N4O2/c1-18-22(25(35)31-21-10-5-9-20(15-21)26(27,28)29)16-23(19-7-3-2-4-8-19)33(18)13-6-12-32-14-11-30-24(34)17-32/h2-5,7-10,15-16H,6,11-14,17H2,1H3,(H,30,34)(H,31,35)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230174
PNG
(US9340500, I-018)
Show SMILES CN(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H26F3N3O/c1-17-21(23(31)28-20-12-7-11-19(15-20)24(25,26)27)16-22(18-9-5-4-6-10-18)30(17)14-8-13-29(2)3/h4-7,9-12,15-16H,8,13-14H2,1-3H3,(H,28,31)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230180
PNG
(US9340500, I-024)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-8-21(9-11-22)26(27,28)29)18-24(20-6-3-2-4-7-20)32(19)13-5-12-31-14-16-34-17-15-31/h2-4,6-11,18H,5,12-17H2,1H3,(H,30,33)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230158
PNG
(US9340500, I-002)
Show SMILES Cc1c(cc(n1CCCN1CCOCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H32F3N3O2/c1-17-20(22(31)28-19-8-5-7-18(15-19)24(25,26)27)16-21(23(2,3)4)30(17)10-6-9-29-11-13-32-14-12-29/h5,7-8,15-16H,6,9-14H2,1-4H3,(H,28,31)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230239
PNG
(US9340500, I-083)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H26F3N3O2/c1-18-22(24(32)29-21-9-5-8-20(16-21)25(26,27)28)17-23(19-6-3-2-4-7-19)31(18)11-10-30-12-14-33-15-13-30/h2-9,16-17H,10-15H2,1H3,(H,29,32)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230219
PNG
(US9340500, I-063)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1ccno1
Show InChI InChI=1S/C27H25F3N4O3/c1-18-22(25(35)32-21-11-6-10-20(16-21)27(28,29)30)17-23(19-8-4-3-5-9-19)34(18)15-7-14-33(2)26(36)24-12-13-31-37-24/h3-6,8-13,16-17H,7,14-15H2,1-2H3,(H,32,35)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230226
PNG
(US9340500, I-070)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(C)=O
Show InChI InChI=1S/C25H26F3N3O2/c1-17-22(24(33)29-21-12-7-11-20(15-21)25(26,27)28)16-23(19-9-5-4-6-10-19)31(17)14-8-13-30(3)18(2)32/h4-7,9-12,15-16H,8,13-14H2,1-3H3,(H,29,33)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230177
PNG
(US9340500, I-021)
Show SMILES Cc1c(cc(-c2cccnc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O2/c1-18-22(24(33)30-21-7-2-6-20(15-21)25(26,27)28)16-23(19-5-3-8-29-17-19)32(18)10-4-9-31-11-13-34-14-12-31/h2-3,5-8,15-17H,4,9-14H2,1H3,(H,30,33)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230188
PNG
(US9340500, I-032)
Show SMILES CC(C)CN(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H32F3N3O/c1-19(2)18-32(4)14-9-15-33-20(3)24(17-25(33)21-10-6-5-7-11-21)26(34)31-23-13-8-12-22(16-23)27(28,29)30/h5-8,10-13,16-17,19H,9,14-15,18H2,1-4H3,(H,31,34)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230166
PNG
(US9340500, I-010)
Show SMILES COCCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N2O2/c1-16-20(22(29)27-19-11-6-10-18(14-19)23(24,25)26)15-21(17-8-4-3-5-9-17)28(16)12-7-13-30-2/h3-6,8-11,14-15H,7,12-13H2,1-2H3,(H,27,29)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230182
PNG
(US9340500, I-026)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCNS(C)(=O)=O)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N3O3S/c1-16-20(22(30)28-19-11-6-10-18(14-19)23(24,25)26)15-21(17-8-4-3-5-9-17)29(16)13-7-12-27-33(2,31)32/h3-6,8-11,14-15,27H,7,12-13H2,1-2H3,(H,28,30)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230240
PNG
(US9340500, I-084)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCSCc1c(F)cccc1Cl)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H23ClF4N2OS/c1-18-22(27(36)34-21-10-5-9-20(15-21)28(31,32)33)16-26(19-7-3-2-4-8-19)35(18)13-14-37-17-23-24(29)11-6-12-25(23)30/h2-12,15-16H,13-14,17H2,1H3,(H,34,36)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230165
PNG
(US9340500, I-009)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C25H29N3O2/c1-20-23(25(29)26-22-11-6-3-7-12-22)19-24(21-9-4-2-5-10-21)28(20)14-8-13-27-15-17-30-18-16-27/h2-7,9-12,19H,8,13-18H2,1H3,(H,26,29)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230281
PNG
(US9340500, I-125)
Show SMILES Cc1c(cc(n1CC(F)(F)CN1CCNCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H31F5N4O/c1-16-19(21(34)31-18-7-5-6-17(12-18)24(27,28)29)13-20(22(2,3)4)33(16)15-23(25,26)14-32-10-8-30-9-11-32/h5-7,12-13,30H,8-11,14-15H2,1-4H3,(H,31,34)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230240
PNG
(US9340500, I-084)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCSCc1c(F)cccc1Cl)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H23ClF4N2OS/c1-18-22(27(36)34-21-10-5-9-20(15-21)28(31,32)33)16-26(19-7-3-2-4-8-19)35(18)13-14-37-17-23-24(29)11-6-12-25(23)30/h2-12,15-16H,13-14,17H2,1H3,(H,34,36)
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Test Example 2: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230183
PNG
(US9340500, I-027)
Show SMILES COC(=O)NCCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N3O3/c1-16-20(22(31)29-19-11-6-10-18(14-19)24(25,26)27)15-21(17-8-4-3-5-9-17)30(16)13-7-12-28-23(32)33-2/h3-6,8-11,14-15H,7,12-13H2,1-2H3,(H,28,32)(H,29,31)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230162
PNG
(US9340500, I-006)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCO)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H21F3N2O2/c1-15-19(21(29)26-18-10-5-9-17(13-18)22(23,24)25)14-20(27(15)11-6-12-28)16-7-3-2-4-8-16/h2-5,7-10,13-14,28H,6,11-12H2,1H3,(H,26,29)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230178
PNG
(US9340500, I-022)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H28F3N3O2/c1-19-21(25(33)30-23-11-6-5-10-22(23)26(27,28)29)18-24(20-8-3-2-4-9-20)32(19)13-7-12-31-14-16-34-17-15-31/h2-6,8-11,18H,7,12-17H2,1H3,(H,30,33)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230171
PNG
(US9340500, I-015)
Show SMILES CC(=O)N1CCN(CCCn2c(C)c(cc2-c2ccccc2)C(=O)Nc2cccc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C28H31F3N4O2/c1-20-25(27(37)32-24-11-6-10-23(18-24)28(29,30)31)19-26(22-8-4-3-5-9-22)35(20)13-7-12-33-14-16-34(17-15-33)21(2)36/h3-6,8-11,18-19H,7,12-17H2,1-2H3,(H,32,37)
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Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230283
PNG
(US9340500, I-127)
Show SMILES Cc1c(cc(n1CCCN1CCOCC1)C(C)(C)C)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H32N4O/c1-17-18(22-24-19-8-5-6-9-20(19)25-22)16-21(23(2,3)4)27(17)11-7-10-26-12-14-28-15-13-26/h5-6,8-9,16H,7,10-15H2,1-4H3,(H,24,25)
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US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230181
PNG
(US9340500, I-025)
Show SMILES CC(=O)NCCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N3O2/c1-16-21(23(32)29-20-11-6-10-19(14-20)24(25,26)27)15-22(18-8-4-3-5-9-18)30(16)13-7-12-28-17(2)31/h3-6,8-11,14-15H,7,12-13H2,1-2H3,(H,28,31)(H,29,32)
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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230184
PNG
(US9340500, I-028)
Show SMILES FC(F)(F)c1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H25F6N3O2/c27-25(28,29)19-8-4-9-20(16-19)33-24(36)21-17-22(18-6-2-1-3-7-18)35(23(21)26(30,31)32)11-5-10-34-12-14-37-15-13-34/h1-4,6-9,16-17H,5,10-15H2,(H,33,36)
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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230237
PNG
(US9340500, I-081)
Show SMILES Cc1c(NC(=O)Nc2cccc(c2)C(F)(F)F)cc(-c2ccccc2)n1CCCN1CCOCC1
Show InChI InChI=1S/C26H29F3N4O2/c1-19-23(31-25(34)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)33(19)12-6-11-32-13-15-35-16-14-32/h2-5,7-10,17-18H,6,11-16H2,1H3,(H2,30,31,34)
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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230282
PNG
(US9340500, I-126)
Show SMILES Cc1c(cc(n1CCCN1CCNCC1)C(C)(C)C)-c1nc2ccccc2o1
Show InChI InChI=1S/C23H32N4O/c1-17-18(22-25-19-8-5-6-9-20(19)28-22)16-21(23(2,3)4)27(17)13-7-12-26-14-10-24-11-15-26/h5-6,8-9,16,24H,7,10-15H2,1-4H3
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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230284
PNG
(US9340500, I-128)
Show SMILES Cc1c(cc(n1CCCN1CCNCC1)C(C)(C)C)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H33N5/c1-17-18(22-25-19-8-5-6-9-20(19)26-22)16-21(23(2,3)4)28(17)13-7-12-27-14-10-24-11-15-27/h5-6,8-9,16,24H,7,10-15H2,1-4H3,(H,25,26)
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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230285
PNG
(US9340500, I-129)
Show SMILES CNCCCn1c(C)c(cc1C(C)(C)C)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H28N4/c1-14-15(19-22-16-9-6-7-10-17(16)23-19)13-18(20(2,3)4)24(14)12-8-11-21-5/h6-7,9-10,13,21H,8,11-12H2,1-5H3,(H,22,23)
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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230236
PNG
(US9340500, I-080)
Show SMILES Cc1c(NS(=O)(=O)c2cccc(c2)C(F)(F)F)cc(-c2ccccc2)n1CCCN1CCOCC1
Show InChI InChI=1S/C25H28F3N3O3S/c1-19-23(29-35(32,33)22-10-5-9-21(17-22)25(26,27)28)18-24(20-7-3-2-4-8-20)31(19)12-6-11-30-13-15-34-16-14-30/h2-5,7-10,17-18,29H,6,11-16H2,1H3
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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230163
PNG
(US9340500, I-007)
Show SMILES Cc1c(ccn1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H24F3N3O2/c1-15-18(6-9-26(15)8-3-7-25-10-12-28-13-11-25)19(27)24-17-5-2-4-16(14-17)20(21,22)23/h2,4-6,9,14H,3,7-8,10-13H2,1H3,(H,24,27)
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Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%