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Patent code US9340506

Compile Data Set for Download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hexokinase type IV


(Homo sapiens (Human))
BDBM229603
PNG
(US9340506, A-11)
Show SMILES Fc1cnc(NC(=O)C(OC2CCOCC2)c2ccc(cc2)S(=O)(=O)N2CCOCC2)s1
Show InChI InChI=1S/C20H24FN3O6S2/c21-17-13-22-20(31-17)23-19(25)18(30-15-5-9-28-10-6-15)14-1-3-16(4-2-14)32(26,27)24-7-11-29-12-8-24/h1-4,13,15,18H,5-12H2,(H,22,23,25)
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n/an/an/an/a 950n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM228464
PNG
(BDBM229621 | US9340506, G4B)
Show SMILES Fc1ccc(OC(C(=O)Nc2ncc(s2)-n2cccn2)c2ccc(cc2)S(=O)(=O)C2CC2)c(F)c1
Show InChI InChI=1S/C23H18F2N4O4S2/c24-15-4-9-19(18(25)12-15)33-21(14-2-5-16(6-3-14)35(31,32)17-7-8-17)22(30)28-23-26-13-20(34-23)29-11-1-10-27-29/h1-6,9-13,17,21H,7-8H2,(H,26,28,30)
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n/an/an/an/a 260n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229606
PNG
(US9340506, A-58)
Show SMILES CC(C)(C)OC(=O)c1ccc(NC(=O)C(Oc2ccc(F)cc2F)c2ccc(cc2)S(=O)(=O)N2CCOCC2)nc1
Show InChI InChI=1S/C28H29F2N3O7S/c1-28(2,3)40-27(35)19-6-11-24(31-17-19)32-26(34)25(39-23-10-7-20(29)16-22(23)30)18-4-8-21(9-5-18)41(36,37)33-12-14-38-15-13-33/h4-11,16-17,25H,12-15H2,1-3H3,(H,31,32,34)
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n/an/an/an/a>1.00E+4n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229611
PNG
(US9340506, B-23)
Show SMILES OC(=O)c1cc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)ccc1Cl
Show InChI InChI=1S/C26H25ClN2O8S2/c27-21-8-3-17(13-20(21)25(31)32)36-22-14-28-26(38-22)29-24(30)23(37-16-9-11-35-12-10-16)15-1-4-18(5-2-15)39(33,34)19-6-7-19/h1-5,8,13-14,16,19,23H,6-7,9-12H2,(H,31,32)(H,28,29,30)
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n/an/an/an/a 480n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229612
PNG
(US9340506, B-26)
Show SMILES OC(=O)c1cc(no1)-c1ccc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)cc1
Show InChI InChI=1S/C29H27N3O9S2/c33-27(26(40-20-11-13-38-14-12-20)18-3-7-21(8-4-18)43(36,37)22-9-10-22)31-29-30-16-25(42-29)39-19-5-1-17(2-6-19)23-15-24(28(34)35)41-32-23/h1-8,15-16,20,22,26H,9-14H2,(H,34,35)(H,30,31,33)
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n/an/an/an/a 220n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229619
PNG
(US9340506, E3)
Show SMILES OCC(O)c1cnc(NC(=O)C(Oc2ccc(F)cc2F)c2ccc(cc2)S(=O)(=O)C2CC2)s1
Show InChI InChI=1S/C22H20F2N2O6S2/c23-13-3-8-18(16(24)9-13)32-20(21(29)26-22-25-10-19(33-22)17(28)11-27)12-1-4-14(5-2-12)34(30,31)15-6-7-15/h1-5,8-10,15,17,20,27-28H,6-7,11H2,(H,25,26,29)
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n/an/an/an/a 1.20E+3n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM228462
PNG
(BDBM229609 | US9340506, G3B)
Show SMILES OC(=O)Cc1nc(NC(=O)C(OC2CCOCC2)c2ccc(cc2)S(=O)(=O)N2CCCCC2)sc1Cl
Show InChI InChI=1S/C23H28ClN3O7S2/c24-21-18(14-19(28)29)25-23(35-21)26-22(30)20(34-16-8-12-33-13-9-16)15-4-6-17(7-5-15)36(31,32)27-10-2-1-3-11-27/h4-7,16,20H,1-3,8-14H2,(H,28,29)(H,25,26,30)
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n/an/an/an/a 420n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229626
PNG
(US9340506, G11A)
Show SMILES Cc1ccc(Oc2cnc(NC(=O)C(O[C@@H]3CCOC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)cc1C(O)=O
Show InChI InChI=1S/C26H26N2O8S2/c1-15-2-5-17(12-21(15)25(30)31)35-22-13-27-26(37-22)28-24(29)23(36-18-10-11-34-14-18)16-3-6-19(7-4-16)38(32,33)20-8-9-20/h2-7,12-13,18,20,23H,8-11,14H2,1H3,(H,30,31)(H,27,28,29)/t18-,23?/m1/s1
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n/an/an/an/a 570n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM228475
PNG
(BDBM229617 | US9340506, G20A)
Show SMILES OCc1cccc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)c1
Show InChI InChI=1S/C26H28N2O7S2/c29-16-17-2-1-3-20(14-17)34-23-15-27-26(36-23)28-25(30)24(35-19-10-12-33-13-11-19)18-4-6-21(7-5-18)37(31,32)22-8-9-22/h1-7,14-15,19,22,24,29H,8-13,16H2,(H,27,28,30)
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n/an/an/an/a 64n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229610
PNG
(US9340506, B-20)
Show SMILES OC(=O)c1ccc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)cc1Cl
Show InChI InChI=1S/C26H25ClN2O8S2/c27-21-13-17(3-8-20(21)25(31)32)36-22-14-28-26(38-22)29-24(30)23(37-16-9-11-35-12-10-16)15-1-4-18(5-2-15)39(33,34)19-6-7-19/h1-5,8,13-14,16,19,23H,6-7,9-12H2,(H,31,32)(H,28,29,30)
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n/an/an/an/a 590n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229618
PNG
(US9340506, E2)
Show SMILES OCC(O)c1ccc2nc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)sc2n1
Show InChI InChI=1S/C24H27N3O7S2/c28-13-20(29)18-7-8-19-23(25-18)35-24(26-19)27-22(30)21(34-15-9-11-33-12-10-15)14-1-3-16(4-2-14)36(31,32)17-5-6-17/h1-4,7-8,15,17,20-21,28-29H,5-6,9-13H2,(H,26,27,30)
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n/an/an/an/a 1.50E+3n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229623
PNG
(US9340506, G8A)
Show SMILES OC(=O)c1cccc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)c1
Show InChI InChI=1S/C26H26N2O8S2/c29-24(28-26-27-15-22(37-26)35-19-3-1-2-17(14-19)25(30)31)23(36-18-10-12-34-13-11-18)16-4-6-20(7-5-16)38(32,33)21-8-9-21/h1-7,14-15,18,21,23H,8-13H2,(H,30,31)(H,27,28,29)
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n/an/an/an/a 190n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229625
PNG
(US9340506, G10A)
Show SMILES Cc1ccc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)cc1C(O)=O
Show InChI InChI=1S/C27H28N2O8S2/c1-16-2-5-19(14-22(16)26(31)32)36-23-15-28-27(38-23)29-25(30)24(37-18-10-12-35-13-11-18)17-3-6-20(7-4-17)39(33,34)21-8-9-21/h2-7,14-15,18,21,24H,8-13H2,1H3,(H,31,32)(H,28,29,30)
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n/an/an/an/a 230n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229632
PNG
(US9340506, G22A)
Show SMILES OC(=O)c1cncc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)c1
Show InChI InChI=1S/C25H25N3O8S2/c29-23(28-25-27-14-21(37-25)35-18-11-16(24(30)31)12-26-13-18)22(36-17-7-9-34-10-8-17)15-1-3-19(4-2-15)38(32,33)20-5-6-20/h1-4,11-14,17,20,22H,5-10H2,(H,30,31)(H,27,28,29)
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n/an/an/an/a 290n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229633
PNG
(US9340506, G25A)
Show SMILES OC(=O)c1cccc(Oc2cnc(NC(=O)C(O[C@H]3CCOC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)c1
Show InChI InChI=1S/C25H24N2O8S2/c28-23(27-25-26-13-21(36-25)34-17-3-1-2-16(12-17)24(29)30)22(35-18-10-11-33-14-18)15-4-6-19(7-5-15)37(31,32)20-8-9-20/h1-7,12-13,18,20,22H,8-11,14H2,(H,29,30)(H,26,27,28)/t18-,22?/m0/s1
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n/an/an/an/a 200n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229607
PNG
(US9340506, B-4)
Show SMILES OC(=O)C1CCc2nc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)sc2C1
Show InChI InChI=1S/C24H28N2O7S2/c27-22(26-24-25-19-8-3-15(23(28)29)13-20(19)34-24)21(33-16-9-11-32-12-10-16)14-1-4-17(5-2-14)35(30,31)18-6-7-18/h1-2,4-5,15-16,18,21H,3,6-13H2,(H,28,29)(H,25,26,27)
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n/an/an/an/a 3.70E+3n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229608
PNG
(US9340506, B-9)
Show SMILES Cc1cc(Oc2cnc(NC(=O)C(Oc3ccc(F)cc3F)c3ccc(cc3)S(=O)(=O)C3CC3)s2)ccc1C(O)=O
Show InChI InChI=1S/C28H22F2N2O7S2/c1-15-12-18(5-10-21(15)27(34)35)38-24-14-31-28(40-24)32-26(33)25(39-23-11-4-17(29)13-22(23)30)16-2-6-19(7-3-16)41(36,37)20-8-9-20/h2-7,10-14,20,25H,8-9H2,1H3,(H,34,35)(H,31,32,33)
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n/an/an/an/a 93n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM228462
PNG
(BDBM229609 | US9340506, G3B)
Show SMILES OC(=O)Cc1nc(NC(=O)C(OC2CCOCC2)c2ccc(cc2)S(=O)(=O)N2CCCCC2)sc1Cl
Show InChI InChI=1S/C23H28ClN3O7S2/c24-21-18(14-19(28)29)25-23(35-21)26-22(30)20(34-16-8-12-33-13-9-16)15-4-6-17(7-5-15)36(31,32)27-10-2-1-3-11-27/h4-7,16,20H,1-3,8-14H2,(H,28,29)(H,25,26,30)
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n/an/an/an/a 1.12E+3n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229614
PNG
(US9340506, B-58)
Show SMILES OC(=O)c1ccc(NC(=O)C(Oc2ccc(Cl)cc2)c2ccc(cc2)S(=O)(=O)C2CC2)nc1
Show InChI InChI=1S/C23H19ClN2O6S/c24-16-4-6-17(7-5-16)32-21(22(27)26-20-12-3-15(13-25-20)23(28)29)14-1-8-18(9-2-14)33(30,31)19-10-11-19/h1-9,12-13,19,21H,10-11H2,(H,28,29)(H,25,26,27)
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n/an/an/an/a 740n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229622
PNG
(US9340506, G5A)
Show SMILES CC(C)(C(O)=O)c1ccc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)cc1
Show InChI InChI=1S/C29H32N2O8S2/c1-29(2,27(33)34)19-5-7-20(8-6-19)38-24-17-30-28(40-24)31-26(32)25(39-21-13-15-37-16-14-21)18-3-9-22(10-4-18)41(35,36)23-11-12-23/h3-10,17,21,23,25H,11-16H2,1-2H3,(H,33,34)(H,30,31,32)
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n/an/an/an/a 94n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229624
PNG
(US9340506, G9A)
Show SMILES COc1cc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)ccc1C(O)=O
Show InChI InChI=1S/C27H28N2O9S2/c1-35-22-14-18(4-9-21(22)26(31)32)37-23-15-28-27(39-23)29-25(30)24(38-17-10-12-36-13-11-17)16-2-5-19(6-3-16)40(33,34)20-7-8-20/h2-6,9,14-15,17,20,24H,7-8,10-13H2,1H3,(H,31,32)(H,28,29,30)
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n/an/an/an/a 270n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229615
PNG
(US9340506, C3)
Show SMILES O=C(Nc1ncc(Oc2ccc(cc2)C(=O)NC2CC2)s1)C(OC1CCOCC1)c1ccc(cc1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C29H31N3O7S2/c33-27(31-20-5-6-20)19-1-7-21(8-2-19)38-25-17-30-29(40-25)32-28(34)26(39-22-13-15-37-16-14-22)18-3-9-23(10-4-18)41(35,36)24-11-12-24/h1-4,7-10,17,20,22,24,26H,5-6,11-16H2,(H,31,33)(H,30,32,34)
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ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229616
PNG
(US9340506, D1)
Show SMILES OCc1ccc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)cc1
Show InChI InChI=1S/C26H28N2O7S2/c29-16-17-1-5-19(6-2-17)34-23-15-27-26(36-23)28-25(30)24(35-20-11-13-33-14-12-20)18-3-7-21(8-4-18)37(31,32)22-9-10-22/h1-8,15,20,22,24,29H,9-14,16H2,(H,27,28,30)
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ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM228461
PNG
(BDBM229620 | US9340506, G1B)
Show SMILES Cc1cc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)ccc1C(O)=O
Show InChI InChI=1S/C27H28N2O8S2/c1-16-14-19(4-9-22(16)26(31)32)36-23-15-28-27(38-23)29-25(30)24(37-18-10-12-35-13-11-18)17-2-5-20(6-3-17)39(33,34)21-7-8-21/h2-6,9,14-15,18,21,24H,7-8,10-13H2,1H3,(H,31,32)(H,28,29,30)
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ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM228464
PNG
(BDBM229621 | US9340506, G4B)
Show SMILES Fc1ccc(OC(C(=O)Nc2ncc(s2)-n2cccn2)c2ccc(cc2)S(=O)(=O)C2CC2)c(F)c1
Show InChI InChI=1S/C23H18F2N4O4S2/c24-15-4-9-19(18(25)12-15)33-21(14-2-5-16(6-3-14)35(31,32)17-7-8-17)22(30)28-23-26-13-20(34-23)29-11-1-10-27-29/h1-6,9-13,17,21H,7-8H2,(H,26,28,30)
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n/an/an/an/a 640n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229627
PNG
(US9340506, G12A)
Show SMILES OC(=O)c1cnn(c1)-c1cnc(NC(=O)C(OC2CCOCC2)c2ccc(cc2)S(=O)(=O)C2CC2)s1
Show InChI InChI=1S/C23H24N4O7S2/c28-21(26-23-24-12-19(35-23)27-13-15(11-25-27)22(29)30)20(34-16-7-9-33-10-8-16)14-1-3-17(4-2-14)36(31,32)18-5-6-18/h1-4,11-13,16,18,20H,5-10H2,(H,29,30)(H,24,26,28)
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ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229628
PNG
(US9340506, G14A)
Show SMILES Cc1cc(Oc2cnc(NC(=O)C(O[C@@H]3CCOC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)ccc1C(O)=O
Show InChI InChI=1S/C26H26N2O8S2/c1-15-12-17(4-9-21(15)25(30)31)35-22-13-27-26(37-22)28-24(29)23(36-18-10-11-34-14-18)16-2-5-19(6-3-16)38(32,33)20-7-8-20/h2-6,9,12-13,18,20,23H,7-8,10-11,14H2,1H3,(H,30,31)(H,27,28,29)/t18-,23?/m1/s1
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ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM228461
PNG
(BDBM229620 | US9340506, G1B)
Show SMILES Cc1cc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)ccc1C(O)=O
Show InChI InChI=1S/C27H28N2O8S2/c1-16-14-19(4-9-22(16)26(31)32)36-23-15-28-27(38-23)29-25(30)24(37-18-10-12-35-13-11-18)17-2-5-20(6-3-17)39(33,34)21-7-8-21/h2-6,9,14-15,18,21,24H,7-8,10-13H2,1H3,(H,31,32)(H,28,29,30)
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ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229630
PNG
(US9340506, G16A)
Show SMILES OC(=O)c1cc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)ccc1F
Show InChI InChI=1S/C26H25FN2O8S2/c27-21-8-3-17(13-20(21)25(31)32)36-22-14-28-26(38-22)29-24(30)23(37-16-9-11-35-12-10-16)15-1-4-18(5-2-15)39(33,34)19-6-7-19/h1-5,8,13-14,16,19,23H,6-7,9-12H2,(H,31,32)(H,28,29,30)
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ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229634
PNG
(US9340506, G26A)
Show SMILES OC(=O)c1cccc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CCCC3)s2)c1
Show InChI InChI=1S/C28H30N2O8S2/c31-26(30-28-29-17-24(39-28)37-21-5-3-4-19(16-21)27(32)33)25(38-20-12-14-36-15-13-20)18-8-10-23(11-9-18)40(34,35)22-6-1-2-7-22/h3-5,8-11,16-17,20,22,25H,1-2,6-7,12-15H2,(H,32,33)(H,29,30,31)
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ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229605
PNG
(US9340506, A-32)
Show SMILES CN1CCC(CC1)OC(C(=O)Nc1ncc(F)s1)c1ccc(cc1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C20H24FN3O4S2/c1-24-10-8-14(9-11-24)28-18(19(25)23-20-22-12-17(21)29-20)13-2-4-15(5-3-13)30(26,27)16-6-7-16/h2-5,12,14,16,18H,6-11H2,1H3,(H,22,23,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229629
PNG
(US9340506, G15A)
Show SMILES OC(=O)c1ccc(NC(=O)C(Oc2ccc(F)cc2F)c2ccc(cc2)S(=O)(=O)C2CC2)nc1
Show InChI InChI=1S/C23H18F2N2O6S/c24-15-4-9-19(18(25)11-15)33-21(22(28)27-20-10-3-14(12-26-20)23(29)30)13-1-5-16(6-2-13)34(31,32)17-7-8-17/h1-6,9-12,17,21H,7-8H2,(H,29,30)(H,26,27,28)
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ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229631
PNG
(US9340506, G19A)
Show SMILES CCOC(=O)c1cccc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)c1
Show InChI InChI=1S/C28H30N2O8S2/c1-2-36-27(32)19-4-3-5-21(16-19)37-24-17-29-28(39-24)30-26(31)25(38-20-12-14-35-15-13-20)18-6-8-22(9-7-18)40(33,34)23-10-11-23/h3-9,16-17,20,23,25H,2,10-15H2,1H3,(H,29,30,31)
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ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229635
PNG
(US9340506, G27A)
Show SMILES OC(=O)c1cccc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(nc3)S(=O)(=O)C3CCCC3)s2)c1
Show InChI InChI=1S/C27H29N3O8S2/c31-25(30-27-29-16-23(39-27)37-20-5-3-4-17(14-20)26(32)33)24(38-19-10-12-36-13-11-19)18-8-9-22(28-15-18)40(34,35)21-6-1-2-7-21/h3-5,8-9,14-16,19,21,24H,1-2,6-7,10-13H2,(H,32,33)(H,29,30,31)
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ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229602
PNG
(US9340506, A-1)
Show SMILES O=C(Nc1nccs1)C(OC1CCOCC1)c1ccc(cc1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C19H22N2O5S2/c22-18(21-19-20-9-12-27-19)17(26-14-7-10-25-11-8-14)13-1-3-15(4-2-13)28(23,24)16-5-6-16/h1-4,9,12,14,16-17H,5-8,10-11H2,(H,20,21,22)
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n/an/an/an/a 1.40E+3n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229613
PNG
(US9340506, B-49)
Show SMILES OC(=O)c1cc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)ccn1
Show InChI InChI=1S/C25H25N3O8S2/c29-23(28-25-27-14-21(37-25)35-17-7-10-26-20(13-17)24(30)31)22(36-16-8-11-34-12-9-16)15-1-3-18(4-2-15)38(32,33)19-5-6-19/h1-4,7,10,13-14,16,19,22H,5-6,8-9,11-12H2,(H,30,31)(H,27,28,29)
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ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM228475
PNG
(BDBM229617 | US9340506, G20A)
Show SMILES OCc1cccc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)C3CC3)s2)c1
Show InChI InChI=1S/C26H28N2O7S2/c29-16-17-2-1-3-20(14-17)34-23-15-27-26(36-23)28-25(30)24(35-19-10-12-33-13-11-19)18-4-6-21(7-5-18)37(31,32)22-8-9-22/h1-7,14-15,19,22,24,29H,8-13,16H2,(H,27,28,30)
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ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM229604
PNG
(US9340506, A-12)
Show SMILES COc1ccc2nc(NC(=O)C(OC3CCOCC3)c3ccc(cc3)S(=O)(=O)N3CCOCC3)sc2n1
Show InChI InChI=1S/C24H28N4O7S2/c1-32-20-7-6-19-23(26-20)36-24(25-19)27-22(29)21(35-17-8-12-33-13-9-17)16-2-4-18(5-3-16)37(30,31)28-10-14-34-15-11-28/h2-7,17,21H,8-15H2,1H3,(H,25,27,29)
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n/an/an/an/a 660n/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%