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Patent code US9340534

Compile Data Set for Download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM227559
PNG
(US9340534, 14)
Show SMILES OC(Cc1cccc(OC(F)(F)F)c1)\C=C\[C@H]1CCS(=O)(=O)N1CCCc1ccc(s1)C(O)=O
Show InChI InChI=1S/C22H24F3NO6S2/c23-22(24,25)32-18-4-1-3-15(14-18)13-17(27)7-6-16-10-12-34(30,31)26(16)11-2-5-19-8-9-20(33-19)21(28)29/h1,3-4,6-9,14,16-17,27H,2,5,10-13H2,(H,28,29)/b7-6+/t16-,17?/m0/s1
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UniProtKB/SwissProt

DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redun...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM227559
PNG
(US9340534, 14)
Show SMILES OC(Cc1cccc(OC(F)(F)F)c1)\C=C\[C@H]1CCS(=O)(=O)N1CCCc1ccc(s1)C(O)=O
Show InChI InChI=1S/C22H24F3NO6S2/c23-22(24,25)32-18-4-1-3-15(14-18)13-17(27)7-6-16-10-12-34(30,31)26(16)11-2-5-19-8-9-20(33-19)21(28)29/h1,3-4,6-9,14,16-17,27H,2,5,10-13H2,(H,28,29)/b7-6+/t16-,17?/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 53n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM227559
PNG
(US9340534, 14)
Show SMILES OC(Cc1cccc(OC(F)(F)F)c1)\C=C\[C@H]1CCS(=O)(=O)N1CCCc1ccc(s1)C(O)=O
Show InChI InChI=1S/C22H24F3NO6S2/c23-22(24,25)32-18-4-1-3-15(14-18)13-17(27)7-6-16-10-12-34(30,31)26(16)11-2-5-19-8-9-20(33-19)21(28)29/h1,3-4,6-9,14,16-17,27H,2,5,10-13H2,(H,28,29)/b7-6+/t16-,17?/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 96n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM227559
PNG
(US9340534, 14)
Show SMILES OC(Cc1cccc(OC(F)(F)F)c1)\C=C\[C@H]1CCS(=O)(=O)N1CCCc1ccc(s1)C(O)=O
Show InChI InChI=1S/C22H24F3NO6S2/c23-22(24,25)32-18-4-1-3-15(14-18)13-17(27)7-6-16-10-12-34(30,31)26(16)11-2-5-19-8-9-20(33-19)21(28)29/h1,3-4,6-9,14,16-17,27H,2,5,10-13H2,(H,28,29)/b7-6+/t16-,17?/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 38n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redun...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%