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Patent code US9340549

Compile Data Set for Download or QSAR
Found 193 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tankyrase-1


(Homo sapiens (Human))
BDBM231074
PNG
(US9340549, 98)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1cnc2[nH]c(=O)n(-c3ncccn3)c2c1
Show InChI InChI=1S/C27H28N6O3/c1-27(2)22(18-7-4-3-5-8-18)32(26(35)36-27)20-11-9-17(10-12-20)19-15-21-23(30-16-19)31-25(34)33(21)24-28-13-6-14-29-24/h3-8,13-17,20,22H,9-12H2,1-2H3,(H,30,31,34)/t17-,20-,22-/m0/s1
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n/an/a 0.316n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231158
PNG
(US9340549, 178)
Show SMILES C[C@H]1OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ccc(cc2[nH]c1=O)C#N
Show InChI InChI=1S/C24H24N4O3/c1-15-22(17-5-3-2-4-6-17)28(24(30)31-15)19-10-8-18(9-11-19)27-21-12-7-16(14-25)13-20(21)26-23(27)29/h2-7,12-13,15,18-19,22H,8-11H2,1H3,(H,26,29)/t15-,18-,19-,22-/m1/s1
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n/an/a 0.375n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231152
PNG
(US9340549, 174)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@H](CC1)c1cnc2ccn(-c3ncccn3)c2c1
Show InChI InChI=1S/C28H29N5O2/c1-28(2)25(20-7-4-3-5-8-20)33(27(34)35-28)22-11-9-19(10-12-22)21-17-24-23(31-18-21)13-16-32(24)26-29-14-6-15-30-26/h3-8,13-19,22,25H,9-12H2,1-2H3/t19-,22+,25-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM50434155
PNG
(CHEMBL2381946 | US9340549, 60)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ccc(C#N)c(F)c2[nH]c1=O
Show InChI InChI=1S/C25H25FN4O3/c1-25(2)22(15-6-4-3-5-7-15)30(24(32)33-25)18-11-9-17(10-12-18)29-19-13-8-16(14-27)20(26)21(19)28-23(29)31/h3-8,13,17-18,22H,9-12H2,1-2H3,(H,28,31)/t17-,18-,22-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231030
PNG
(US9340549, 47)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ccc(cc2[nH]c1=O)C#N
Show InChI InChI=1S/C25H26N4O3/c1-25(2)22(17-6-4-3-5-7-17)29(24(31)32-25)19-11-9-18(10-12-19)28-21-13-8-16(15-26)14-20(21)27-23(28)30/h3-8,13-14,18-19,22H,9-12H2,1-2H3,(H,27,30)/t18-,19-,22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM50444583
PNG
(CHEMBL3099716 | US9340549, 74)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1cnc(N)c(c1)-c1ncccn1
Show InChI InChI=1S/C26H29N5O2/c1-26(2)22(18-7-4-3-5-8-18)31(25(32)33-26)20-11-9-17(10-12-20)19-15-21(23(27)30-16-19)24-28-13-6-14-29-24/h3-8,13-17,20,22H,9-12H2,1-2H3,(H2,27,30)/t17-,20-,22-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231039
PNG
(US9340549, 56)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ncc(Br)cc2[nH]c1=O
Show InChI InChI=1S/C23H25BrN4O3/c1-23(2)19(14-6-4-3-5-7-14)27(22(30)31-23)16-8-10-17(11-9-16)28-20-18(26-21(28)29)12-15(24)13-25-20/h3-7,12-13,16-17,19H,8-11H2,1-2H3,(H,26,29)/t16-,17-,19-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231038
PNG
(US9340549, 55)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccc(F)cc1)[C@H]1CC[C@@H](CC1)n1c2ccncc2[nH]c1=O
Show InChI InChI=1S/C23H25FN4O3/c1-23(2)20(14-3-5-15(24)6-4-14)28(22(30)31-23)17-9-7-16(8-10-17)27-19-11-12-25-13-18(19)26-21(27)29/h3-6,11-13,16-17,20H,7-10H2,1-2H3,(H,26,29)/t16-,17-,20-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231070
PNG
(US9340549, 93)
Show SMILES C[C@]1(CN([C@H]2CC[C@H](CC2)n2c3ccc(cc3[nH]c2=O)C#N)C(=O)O1)c1ccccc1
Show InChI InChI=1S/C24H24N4O3/c1-24(17-5-3-2-4-6-17)15-27(23(30)31-24)18-8-10-19(11-9-18)28-21-12-7-16(14-25)13-20(21)26-22(28)29/h2-7,12-13,18-19H,8-11,15H2,1H3,(H,26,29)/t18-,19+,24-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231005
PNG
(US9340549, 23)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ccncc2[nH]c1=O
Show InChI InChI=1S/C23H26N4O3/c1-23(2)20(15-6-4-3-5-7-15)27(22(29)30-23)17-10-8-16(9-11-17)26-19-12-13-24-14-18(19)25-21(26)28/h3-7,12-14,16-17,20H,8-11H2,1-2H3,(H,25,28)/t16-,17-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231042
PNG
(US9340549, 61)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccc(F)cc1)[C@H]1CC[C@@H](CC1)n1c2ccc(cc2[nH]c1=O)C#N
Show InChI InChI=1S/C25H25FN4O3/c1-25(2)22(16-4-6-17(26)7-5-16)30(24(32)33-25)19-10-8-18(9-11-19)29-21-12-3-15(14-27)13-20(21)28-23(29)31/h3-7,12-13,18-19,22H,8-11H2,1-2H3,(H,28,31)/t18-,19-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM50434156
PNG
(CHEMBL2381945 | US9340549, 103)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2cc(F)c(cc2[nH]c1=O)C#N
Show InChI InChI=1S/C25H25FN4O3/c1-25(2)22(15-6-4-3-5-7-15)30(24(32)33-25)18-10-8-17(9-11-18)29-21-13-19(26)16(14-27)12-20(21)28-23(29)31/h3-7,12-13,17-18,22H,8-11H2,1-2H3,(H,28,31)/t17-,18-,22-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231034
PNG
(US9340549, 51)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2cccc(C#N)c2[nH]c1=O
Show InChI InChI=1S/C25H26N4O3/c1-25(2)22(16-7-4-3-5-8-16)29(24(31)32-25)19-13-11-18(12-14-19)28-20-10-6-9-17(15-26)21(20)27-23(28)30/h3-10,18-19,22H,11-14H2,1-2H3,(H,27,30)/t18-,19-,22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM50434158
PNG
(CHEMBL2381936 | US9340549, 59)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccnc2cc(F)cnc12
Show InChI InChI=1S/C26H27FN4O3/c1-26(2)23(16-6-4-3-5-7-16)31(25(33)34-26)19-10-8-18(9-11-19)30-24(32)20-12-13-28-21-14-17(27)15-29-22(20)21/h3-7,12-15,18-19,23H,8-11H2,1-2H3,(H,30,32)/t18-,19-,23-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231163
PNG
(US9340549, 183)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1csc(n1)-c1ncccn1
Show InChI InChI=1S/C25H27N5O3S/c1-25(2)20(16-7-4-3-5-8-16)30(24(32)33-25)18-11-9-17(10-12-18)28-22(31)19-15-34-23(29-19)21-26-13-6-14-27-21/h3-8,13-15,17-18,20H,9-12H2,1-2H3,(H,28,31)/t17-,18-,20-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231060
PNG
(US9340549, 83)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2cnccc2[nH]c1=O
Show InChI InChI=1S/C23H26N4O3/c1-23(2)20(15-6-4-3-5-7-15)27(22(29)30-23)17-10-8-16(9-11-17)26-19-14-24-13-12-18(19)25-21(26)28/h3-7,12-14,16-17,20H,8-11H2,1-2H3,(H,25,28)/t16-,17-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231007
PNG
(US9340549, 25)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccnc2cccnc12
Show InChI InChI=1S/C26H28N4O3/c1-26(2)23(17-7-4-3-5-8-17)30(25(32)33-26)19-12-10-18(11-13-19)29-24(31)20-14-16-27-21-9-6-15-28-22(20)21/h3-9,14-16,18-19,23H,10-13H2,1-2H3,(H,29,31)/t18-,19-,23-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-2


(Homo sapiens (Human))
BDBM231008
PNG
(US9340549, 26 | US9340549, 27)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1cccc2cccnc12
Show InChI InChI=1S/C27H29N3O3/c1-27(2)24(19-8-4-3-5-9-19)30(26(32)33-27)21-15-13-20(14-16-21)29-25(31)22-12-6-10-18-11-7-17-28-23(18)22/h3-12,17,20-21,24H,13-16H2,1-2H3,(H,29,31)/t20-,21-,24-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231069
PNG
(US9340549, 92)
Show SMILES CC1(CN([C@H]2CC[C@H](CC2)n2c3ccc(cc3[nH]c2=O)C#N)C(=O)O1)c1ccccc1
Show InChI InChI=1S/C24H24N4O3/c1-24(17-5-3-2-4-6-17)15-27(23(30)31-24)18-8-10-19(11-9-18)28-21-12-7-16(14-25)13-20(21)26-22(28)29/h2-7,12-13,18-19H,8-11,15H2,1H3,(H,26,29)/t18-,19+,24?
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-2


(Homo sapiens (Human))
BDBM231012
PNG
(US9340549, 29)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ccc(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C24H26ClN3O3/c1-24(2)21(15-6-4-3-5-7-15)28(23(30)31-24)18-11-9-17(10-12-18)27-20-13-8-16(25)14-19(20)26-22(27)29/h3-8,13-14,17-18,21H,9-12H2,1-2H3,(H,26,29)/t17-,18-,21-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231033
PNG
(US9340549, 50)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ncncc2[nH]c1=O
Show InChI InChI=1S/C22H25N5O3/c1-22(2)18(14-6-4-3-5-7-14)26(21(29)30-22)15-8-10-16(11-9-15)27-19-17(25-20(27)28)12-23-13-24-19/h3-7,12-13,15-16,18H,8-11H2,1-2H3,(H,25,28)/t15-,16-,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231111
PNG
(US9340549, 136)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)C1CC[C@@H](CC1)c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C24H27N3O2/c1-24(2)21(17-6-4-3-5-7-17)27(23(28)29-24)20-10-8-16(9-11-20)19-14-18-12-13-25-22(18)26-15-19/h3-7,12-16,20-21H,8-11H2,1-2H3,(H,25,26)/t16-,20?,21-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231131
PNG
(US9340549, 156)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C27H29N3O3S/c1-27(2)23(18-9-5-3-6-10-18)30(26(32)33-27)21-15-13-20(14-16-21)28-24(31)22-17-34-25(29-22)19-11-7-4-8-12-19/h3-12,17,20-21,23H,13-16H2,1-2H3,(H,28,31)/t20-,21-,23-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231012
PNG
(US9340549, 29)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ccc(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C24H26ClN3O3/c1-24(2)21(15-6-4-3-5-7-15)28(23(30)31-24)18-11-9-17(10-12-18)27-20-13-8-16(25)14-19(20)26-22(27)29/h3-8,13-14,17-18,21H,9-12H2,1-2H3,(H,26,29)/t17-,18-,21-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-2


(Homo sapiens (Human))
BDBM231007
PNG
(US9340549, 25)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccnc2cccnc12
Show InChI InChI=1S/C26H28N4O3/c1-26(2)23(17-7-4-3-5-8-17)30(25(32)33-26)19-12-10-18(11-13-19)29-24(31)20-14-16-27-21-9-6-15-28-22(20)21/h3-9,14-16,18-19,23H,10-13H2,1-2H3,(H,29,31)/t18-,19-,23-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231036
PNG
(US9340549, 53)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2cc(Cl)ncc2[nH]c1=O
Show InChI InChI=1S/C23H25ClN4O3/c1-23(2)20(14-6-4-3-5-7-14)28(22(30)31-23)16-10-8-15(9-11-16)27-18-12-19(24)25-13-17(18)26-21(27)29/h3-7,12-13,15-16,20H,8-11H2,1-2H3,(H,26,29)/t15-,16-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231164
PNG
(US9340549, 87)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)C1CCc(cC1)-c1cc2ccncc2[nH]c1=O
Show InChI InChI=1S/C25H25N3O3/c1-25(2)22(17-6-4-3-5-7-17)28(24(30)31-25)19-10-8-16(9-11-19)20-14-18-12-13-26-15-21(18)27-23(20)29/h3-8,12-15,19,22H,9-11H2,1-2H3,(H,27,29)/t19?,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM50444584
PNG
(CHEMBL3099718 | US9340549, 95)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1cnc(N)c(c1)C#N
Show InChI InChI=1S/C23H26N4O2/c1-23(2)20(16-6-4-3-5-7-16)27(22(28)29-23)19-10-8-15(9-11-19)18-12-17(13-24)21(25)26-14-18/h3-7,12,14-15,19-20H,8-11H2,1-2H3,(H2,25,26)/t15-,19-,20-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231037
PNG
(US9340549, 54)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2cc(ncc2[nH]c1=O)C#N
Show InChI InChI=1S/C24H25N5O3/c1-24(2)21(15-6-4-3-5-7-15)29(23(31)32-24)18-10-8-17(9-11-18)28-20-12-16(13-25)26-14-19(20)27-22(28)30/h3-7,12,14,17-18,21H,8-11H2,1-2H3,(H,27,30)/t17-,18-,21-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231041
PNG
(US9340549, 58)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)n1ccc2cccnc12
Show InChI InChI=1S/C25H28N4O3/c1-25(2)21(17-7-4-3-5-8-17)29(24(31)32-25)20-12-10-19(11-13-20)27-23(30)28-16-14-18-9-6-15-26-22(18)28/h3-9,14-16,19-21H,10-13H2,1-2H3,(H,27,30)/t19-,20-,21-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231043
PNG
(US9340549, 62)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)N1Cc2cc(ccc2NC1=O)C#N
Show InChI InChI=1S/C26H28N4O3/c1-26(2)23(18-6-4-3-5-7-18)30(25(32)33-26)21-11-9-20(10-12-21)29-16-19-14-17(15-27)8-13-22(19)28-24(29)31/h3-8,13-14,20-21,23H,9-12,16H2,1-2H3,(H,28,31)/t20-,21-,23-/m0/s1
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US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM50444583
PNG
(CHEMBL3099716 | US9340549, 74)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1cnc(N)c(c1)-c1ncccn1
Show InChI InChI=1S/C26H29N5O2/c1-26(2)22(18-7-4-3-5-8-18)31(25(32)33-26)20-11-9-17(10-12-20)19-15-21(23(27)30-16-19)24-28-13-6-14-29-24/h3-8,13-17,20,22H,9-12H2,1-2H3,(H2,27,30)/t17-,20-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231068
PNG
(US9340549, 91)
Show SMILES C[C@@]1(CN([C@H]2CC[C@@H](CC2)n2c3ccncc3[nH]c2=O)C(=O)O1)c1ccccc1
Show InChI InChI=1S/C22H24N4O3/c1-22(15-5-3-2-4-6-15)14-25(21(28)29-22)16-7-9-17(10-8-16)26-19-11-12-23-13-18(19)24-20(26)27/h2-6,11-13,16-17H,7-10,14H2,1H3,(H,24,27)/t16-,17-,22-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231121
PNG
(US9340549, 146)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C24H27N5O3/c1-24(2)20(16-7-4-3-5-8-16)29(23(31)32-24)18-11-9-17(10-12-18)27-22(30)19-15-26-28-14-6-13-25-21(19)28/h3-8,13-15,17-18,20H,9-12H2,1-2H3,(H,27,30)/t17-,18-,20-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231150
PNG
(US9340549, 173)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CCC(=CC1)c1cnc2ccn(-c3ncccn3)c2c1
Show InChI InChI=1S/C28H27N5O2/c1-28(2)25(20-7-4-3-5-8-20)33(27(34)35-28)22-11-9-19(10-12-22)21-17-24-23(31-18-21)13-16-32(24)26-29-14-6-15-30-26/h3-9,13-18,22,25H,10-12H2,1-2H3/t22-,25+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231008
PNG
(US9340549, 26 | US9340549, 27)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1cccc2cccnc12
Show InChI InChI=1S/C27H29N3O3/c1-27(2)24(19-8-4-3-5-9-19)30(26(32)33-27)21-15-13-20(14-16-21)29-25(31)22-12-6-10-18-11-7-17-28-23(18)22/h3-12,17,20-21,24H,13-16H2,1-2H3,(H,29,31)/t20-,21-,24-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231013
PNG
(US9340549, 30)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2cccnc2[nH]c1=O
Show InChI InChI=1S/C23H26N4O3/c1-23(2)19(15-7-4-3-5-8-15)27(22(29)30-23)17-12-10-16(11-13-17)26-18-9-6-14-24-20(18)25-21(26)28/h3-9,14,16-17,19H,10-13H2,1-2H3,(H,24,25,28)/t16-,17-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-2


(Homo sapiens (Human))
BDBM231015
PNG
(US9340549, 32)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C27H29N3O3/c1-27(2)24(19-8-4-3-5-9-19)30(26(32)33-27)21-15-13-20(14-16-21)25(31)29-22-12-6-10-18-11-7-17-28-23(18)22/h3-12,17,20-21,24H,13-16H2,1-2H3,(H,29,31)/t20-,21-,24-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-2


(Homo sapiens (Human))
BDBM230983
PNG
(US9340549, 1)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)C(=O)Nc1ccnc2cccnc12
Show InChI InChI=1S/C26H22N4O3/c1-26(2)23(17-7-4-3-5-8-17)30(25(32)33-26)19-12-10-18(11-13-19)24(31)29-21-14-16-27-20-9-6-15-28-22(20)21/h3-16,23H,1-2H3,(H,27,29,31)/t23-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231058
PNG
(US9340549, 81)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1cc(c[nH]c1=O)-c1ncccn1
Show InChI InChI=1S/C26H28N4O3/c1-26(2)22(18-7-4-3-5-8-18)30(25(32)33-26)20-11-9-17(10-12-20)21-15-19(16-29-24(21)31)23-27-13-6-14-28-23/h3-8,13-17,20,22H,9-12H2,1-2H3,(H,29,31)/t17-,20-,22-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231123
PNG
(US9340549, 148)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccnc(n1)-c1ccccc1
Show InChI InChI=1S/C28H30N4O3/c1-28(2)24(19-9-5-3-6-10-19)32(27(34)35-28)22-15-13-21(14-16-22)30-26(33)23-17-18-29-25(31-23)20-11-7-4-8-12-20/h3-12,17-18,21-22,24H,13-16H2,1-2H3,(H,30,33)/t21-,22-,24-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231114
PNG
(US9340549, 139)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)C1CC[C@@H](CC1)c1cc2ccncc2[nH]c1=O
Show InChI InChI=1S/C25H27N3O3/c1-25(2)22(17-6-4-3-5-7-17)28(24(30)31-25)19-10-8-16(9-11-19)20-14-18-12-13-26-15-21(18)27-23(20)29/h3-7,12-16,19,22H,8-11H2,1-2H3,(H,27,29)/t16-,19?,22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231018
PNG
(US9340549, 35)
Show SMILES CC1(C)OC(=O)N(C1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C24H27N3O3/c1-24(2)21(16-8-4-3-5-9-16)27(23(29)30-24)18-14-12-17(13-15-18)26-20-11-7-6-10-19(20)25-22(26)28/h3-11,17-18,21H,12-15H2,1-2H3,(H,25,28)/t17-,18-,21?
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AMGEN INC.

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The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231020
PNG
(US9340549, 37)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ncccc2[nH]c1=O
Show InChI InChI=1S/C23H26N4O3/c1-23(2)19(15-7-4-3-5-8-15)26(22(29)30-23)16-10-12-17(13-11-16)27-20-18(25-21(27)28)9-6-14-24-20/h3-9,14,16-17,19H,10-13H2,1-2H3,(H,25,28)/t16-,17-,19-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231065
PNG
(US9340549, 88)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cc2ccncc2[nH]c1=O
Show InChI InChI=1S/C25H21N3O3/c1-25(2)22(17-6-4-3-5-7-17)28(24(30)31-25)19-10-8-16(9-11-19)20-14-18-12-13-26-15-21(18)27-23(20)29/h3-15,22H,1-2H3,(H,27,29)/t22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231120
PNG
(US9340549, 145)
Show SMILES Cn1cc2cccc(C(=O)N[C@H]3CC[C@@H](CC3)N3[C@@H](c4ccccc4)C(C)(C)OC3=O)c2n1
Show InChI InChI=1S/C26H30N4O3/c1-26(2)23(17-8-5-4-6-9-17)30(25(32)33-26)20-14-12-19(13-15-20)27-24(31)21-11-7-10-18-16-29(3)28-22(18)21/h4-11,16,19-20,23H,12-15H2,1-3H3,(H,27,31)/t19-,20-,23-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231075
PNG
(US9340549, 99)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1cnc(N)c(c1)-c1nccc(n1)C(N)=N
Show InChI InChI=1S/C27H31N7O2/c1-27(2)22(17-6-4-3-5-7-17)34(26(35)36-27)19-10-8-16(9-11-19)18-14-20(24(30)32-15-18)25-31-13-12-21(33-25)23(28)29/h3-7,12-16,19,22H,8-11H2,1-2H3,(H3,28,29)(H2,30,32)/t16-,19-,22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231106
PNG
(US9340549, 131)
Show SMILES CC1(C)OC(=O)N(C1c1ccccc1)C1CCc(cC1)-c1cnc(N)c(c1)-c1ncccn1
Show InChI InChI=1S/C26H27N5O2/c1-26(2)22(18-7-4-3-5-8-18)31(25(32)33-26)20-11-9-17(10-12-20)19-15-21(23(27)30-16-19)24-28-13-6-14-29-24/h3-9,13-16,20,22H,10-12H2,1-2H3,(H2,27,30)
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231077
PNG
(US9340549, 101)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cnc(N)c(c1)-c1cnnc(Cl)c1
Show InChI InChI=1S/C26H22ClN5O2/c1-26(2)23(17-6-4-3-5-7-17)32(25(33)34-26)20-10-8-16(9-11-20)18-12-21(24(28)29-14-18)19-13-22(27)31-30-15-19/h3-15,23H,1-2H3,(H2,28,29)/t23-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231015
PNG
(US9340549, 32)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C27H29N3O3/c1-27(2)24(19-8-4-3-5-9-19)30(26(32)33-27)21-15-13-20(14-16-21)25(31)29-22-12-6-10-18-11-7-17-28-23(18)22/h3-12,17,20-21,24H,13-16H2,1-2H3,(H,29,31)/t20-,21-,24-/m0/s1
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AMGEN INC.

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The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231066
PNG
(US9340549, 89)
Show SMILES CC1(CN([C@H]2CC[C@@H](CC2)n2c3ccncc3[nH]c2=O)C(=O)O1)c1ccccc1
Show InChI InChI=1S/C22H24N4O3/c1-22(15-5-3-2-4-6-15)14-25(21(28)29-22)16-7-9-17(10-8-16)26-19-11-12-23-13-18(19)24-20(26)27/h2-6,11-13,16-17H,7-10,14H2,1H3,(H,24,27)/t16-,17-,22?
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230983
PNG
(US9340549, 1)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)C(=O)Nc1ccnc2cccnc12
Show InChI InChI=1S/C26H22N4O3/c1-26(2)23(17-7-4-3-5-8-17)30(25(32)33-26)19-12-10-18(11-13-19)24(31)29-21-14-16-27-20-9-6-15-28-22(20)21/h3-16,23H,1-2H3,(H,27,29,31)/t23-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231148
PNG
(US9340549, 171)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1cnc2cc[nH]c2c1
Show InChI InChI=1S/C24H27N3O2/c1-24(2)22(17-6-4-3-5-7-17)27(23(28)29-24)19-10-8-16(9-11-19)18-14-21-20(26-15-18)12-13-25-21/h3-7,12-16,19,22,25H,8-11H2,1-2H3/t16-,19-,22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231019
PNG
(US9340549, 36)
Show SMILES CC1(C)OC(=O)N(C1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ncccc2[nH]c1=O
Show InChI InChI=1S/C23H26N4O3/c1-23(2)19(15-7-4-3-5-8-15)26(22(29)30-23)16-10-12-17(13-11-16)27-20-18(25-21(27)28)9-6-14-24-20/h3-9,14,16-17,19H,10-13H2,1-2H3,(H,25,28)/t16-,17-,19?
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-2


(Homo sapiens (Human))
BDBM231008
PNG
(US9340549, 26 | US9340549, 27)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1cccc2cccnc12
Show InChI InChI=1S/C27H29N3O3/c1-27(2)24(19-8-4-3-5-9-19)30(26(32)33-27)21-15-13-20(14-16-21)29-25(31)22-12-6-10-18-11-7-17-28-23(18)22/h3-12,17,20-21,24H,13-16H2,1-2H3,(H,29,31)/t20-,21-,24-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231008
PNG
(US9340549, 26 | US9340549, 27)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1cccc2cccnc12
Show InChI InChI=1S/C27H29N3O3/c1-27(2)24(19-8-4-3-5-9-19)30(26(32)33-27)21-15-13-20(14-16-21)29-25(31)22-12-6-10-18-11-7-17-28-23(18)22/h3-12,17,20-21,24H,13-16H2,1-2H3,(H,29,31)/t20-,21-,24-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230987
PNG
(US9340549, 5)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CCC(=CC1)c1cc(c[nH]c1=O)-c1ncccn1
Show InChI InChI=1S/C26H26N4O3/c1-26(2)22(18-7-4-3-5-8-18)30(25(32)33-26)20-11-9-17(10-12-20)21-15-19(16-29-24(21)31)23-27-13-6-14-28-23/h3-9,13-16,20,22H,10-12H2,1-2H3,(H,29,31)/t20-,22+/m1/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231115
PNG
(US9340549, 140)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)C1CCN(CC1)c1cnc2ccn(-c3ncccn3)c2c1
Show InChI InChI=1S/C27H28N6O2/c1-27(2)24(19-7-4-3-5-8-19)33(26(34)35-27)20-9-14-31(15-10-20)21-17-23-22(30-18-21)11-16-32(23)25-28-12-6-13-29-25/h3-8,11-13,16-18,20,24H,9-10,14-15H2,1-2H3/t24-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231035
PNG
(US9340549, 52)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2cc(ncc2[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C24H25F3N4O3/c1-23(2)20(14-6-4-3-5-7-14)31(22(33)34-23)16-10-8-15(9-11-16)30-18-12-19(24(25,26)27)28-13-17(18)29-21(30)32/h3-7,12-13,15-16,20H,8-11H2,1-2H3,(H,29,32)/t15-,16-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-2


(Homo sapiens (Human))
BDBM50444585
PNG
(CHEMBL3099720 | US9340549, 65)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cnc(N)c(c1)-c1ncccn1
Show InChI InChI=1S/C26H23N5O2/c1-26(2)22(18-7-4-3-5-8-18)31(25(32)33-26)20-11-9-17(10-12-20)19-15-21(23(27)30-16-19)24-28-13-6-14-29-24/h3-16,22H,1-2H3,(H2,27,30)/t22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231122
PNG
(US9340549, 147)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2cc[nH]c2n1
Show InChI InChI=1S/C25H28N4O3/c1-25(2)21(16-6-4-3-5-7-16)29(24(31)32-25)19-11-9-18(10-12-19)27-23(30)20-13-8-17-14-15-26-22(17)28-20/h3-8,13-15,18-19,21H,9-12H2,1-2H3,(H,26,28)(H,27,30)/t18-,19-,21-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230996
PNG
(US9340549, 14)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1cnc2[nH]c(=O)n(-c3ncccn3)c2c1
Show InChI InChI=1S/C27H28N6O3/c1-27(2)22(18-7-4-3-5-8-18)32(26(35)36-27)20-11-9-17(10-12-20)19-15-21-23(30-16-19)31-25(34)33(21)24-28-13-6-14-29-24/h3-8,13-17,20,22H,9-12H2,1-2H3,(H,30,31,34)/t17-,20-,22-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230989
PNG
(US9340549, 7)
Show SMILES CC1(C)OC(=O)N(C1c1ccccc1)[C@H]1CC[C@@H](CC1)c1cc(c[nH]c1=O)-c1ncccn1
Show InChI InChI=1S/C26H28N4O3/c1-26(2)22(18-7-4-3-5-8-18)30(25(32)33-26)20-11-9-17(10-12-20)21-15-19(16-29-24(21)31)23-27-13-6-14-28-23/h3-8,13-17,20,22H,9-12H2,1-2H3,(H,29,31)/t17-,20-,22?
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231162
PNG
(US9340549, 182)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1csc(Br)n1
Show InChI InChI=1S/C21H24BrN3O3S/c1-21(2)17(13-6-4-3-5-7-13)25(20(27)28-21)15-10-8-14(9-11-15)23-18(26)16-12-29-19(22)24-16/h3-7,12,14-15,17H,8-11H2,1-2H3,(H,23,26)/t14-,15-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231063
PNG
(US9340549, 86)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C25H27N3O3/c1-25(2)21(17-9-5-3-6-10-17)28(24(29)31-25)20-15-13-19(14-16-20)23-27-26-22(30-23)18-11-7-4-8-12-18/h3-12,19-21H,13-16H2,1-2H3/t19-,20-,21-/m1/s1
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US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231124
PNG
(US9340549, 149)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1cc2ccncc2[nH]1
Show InChI InChI=1S/C25H28N4O3/c1-25(2)22(16-6-4-3-5-7-16)29(24(31)32-25)19-10-8-18(9-11-19)27-23(30)20-14-17-12-13-26-15-21(17)28-20/h3-7,12-15,18-19,22,28H,8-11H2,1-2H3,(H,27,30)/t18-,19-,22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231017
PNG
(US9340549, 34)
Show SMILES CC1(CN([C@H]2CC[C@@H](CC2)n2c3ccccc3[nH]c2=O)C(=O)O1)c1ccccc1
Show InChI InChI=1S/C23H25N3O3/c1-23(16-7-3-2-4-8-16)15-25(22(28)29-23)17-11-13-18(14-12-17)26-20-10-6-5-9-19(20)24-21(26)27/h2-10,17-18H,11-15H2,1H3,(H,24,27)/t17-,18-,23?
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231062
PNG
(US9340549, 85)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C25H27N3O3/c1-25(2)21(17-9-5-3-6-10-17)28(24(29)31-25)20-15-13-19(14-16-20)23-27-26-22(30-23)18-11-7-4-8-12-18/h3-12,19-21H,13-16H2,1-2H3/t19-,20-,21-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230988
PNG
(US9340549, 6)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@@H]1CCC(=CC1)c1cc(c[nH]c1=O)-c1ncccn1
Show InChI InChI=1S/C26H26N4O3/c1-26(2)22(18-7-4-3-5-8-18)30(25(32)33-26)20-11-9-17(10-12-20)21-15-19(16-29-24(21)31)23-27-13-6-14-28-23/h3-9,13-16,20,22H,10-12H2,1-2H3,(H,29,31)/t20-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-2


(Homo sapiens (Human))
BDBM231045
PNG
(US9340549, 64)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cnc(N)c(c1)-c1ncc(F)cn1
Show InChI InChI=1S/C26H22FN5O2/c1-26(2)22(17-6-4-3-5-7-17)32(25(33)34-26)20-10-8-16(9-11-20)18-12-21(23(28)29-13-18)24-30-14-19(27)15-31-24/h3-15,22H,1-2H3,(H2,28,29)/t22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM50444585
PNG
(CHEMBL3099720 | US9340549, 65)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cnc(N)c(c1)-c1ncccn1
Show InChI InChI=1S/C26H23N5O2/c1-26(2)22(18-7-4-3-5-8-18)31(25(32)33-26)20-11-9-17(10-12-20)19-15-21(23(27)30-16-19)24-28-13-6-14-29-24/h3-16,22H,1-2H3,(H2,27,30)/t22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-2


(Homo sapiens (Human))
BDBM230994
PNG
(US9340549, 12)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cnc(N)c(c1)-c1ccc2nncn2n1
Show InChI InChI=1S/C27H23N7O2/c1-27(2)24(18-6-4-3-5-7-18)34(26(35)36-27)20-10-8-17(9-11-20)19-14-21(25(28)29-15-19)22-12-13-23-31-30-16-33(23)32-22/h3-16,24H,1-2H3,(H2,28,29)/t24-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231139
PNG
(US9340549, 164)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1coc(n1)-c1ccccc1
Show InChI InChI=1S/C27H29N3O4/c1-27(2)23(18-9-5-3-6-10-18)30(26(32)34-27)21-15-13-20(14-16-21)28-24(31)22-17-33-25(29-22)19-11-7-4-8-12-19/h3-12,17,20-21,23H,13-16H2,1-2H3,(H,28,31)/t20-,21-,23-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230994
PNG
(US9340549, 12)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cnc(N)c(c1)-c1ccc2nncn2n1
Show InChI InChI=1S/C27H23N7O2/c1-27(2)24(18-6-4-3-5-7-18)34(26(35)36-27)20-10-8-17(9-11-20)19-14-21(25(28)29-15-19)22-12-13-23-31-30-16-33(23)32-22/h3-16,24H,1-2H3,(H2,28,29)/t24-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-2


(Homo sapiens (Human))
BDBM230986
PNG
(US9340549, 4)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cc(c[nH]c1=O)-c1ncccn1
Show InChI InChI=1S/C26H22N4O3/c1-26(2)22(18-7-4-3-5-8-18)30(25(32)33-26)20-11-9-17(10-12-20)21-15-19(16-29-24(21)31)23-27-13-6-14-28-23/h3-16,22H,1-2H3,(H,29,31)/t22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231095
PNG
(US9340549, 120)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cc(c[nH]c1=O)-c1nccc(n1)C#N
Show InChI InChI=1S/C27H21N5O3/c1-27(2)23(18-6-4-3-5-7-18)32(26(34)35-27)21-10-8-17(9-11-21)22-14-19(16-30-25(22)33)24-29-13-12-20(15-28)31-24/h3-14,16,23H,1-2H3,(H,30,33)/t23-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231132
PNG
(US9340549, 157)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C25H28N4O3/c1-25(2)21(16-8-4-3-5-9-16)29(24(31)32-25)18-14-12-17(13-15-18)26-23(30)22-27-19-10-6-7-11-20(19)28-22/h3-11,17-18,21H,12-15H2,1-2H3,(H,26,30)(H,27,28)/t17-,18-,21-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230986
PNG
(US9340549, 4)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cc(c[nH]c1=O)-c1ncccn1
Show InChI InChI=1S/C26H22N4O3/c1-26(2)22(18-7-4-3-5-8-18)30(25(32)33-26)20-11-9-17(10-12-20)21-15-19(16-29-24(21)31)23-27-13-6-14-28-23/h3-16,22H,1-2H3,(H,29,31)/t22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231045
PNG
(US9340549, 64)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cnc(N)c(c1)-c1ncc(F)cn1
Show InChI InChI=1S/C26H22FN5O2/c1-26(2)22(17-6-4-3-5-7-17)32(25(33)34-26)20-10-8-16(9-11-20)18-12-21(23(28)29-13-18)24-30-14-19(27)15-31-24/h3-15,22H,1-2H3,(H2,28,29)/t22-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231144
PNG
(US9340549, 169)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CCC(=CC1)c1cnc2cc[nH]c2c1
Show InChI InChI=1S/C24H25N3O2/c1-24(2)22(17-6-4-3-5-7-17)27(23(28)29-24)19-10-8-16(9-11-19)18-14-21-20(26-15-18)12-13-25-21/h3-8,12-15,19,22,25H,9-11H2,1-2H3/t19-,22+/m1/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231082
PNG
(US9340549, 107)
Show SMILES COc1cccc(c1)[C@@H]1N(C(=O)OC1(C)C)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C28H25N3O4/c1-28(2)25(20-8-4-10-22(17-20)34-3)31(27(33)35-28)21-14-12-19(13-15-21)26(32)30-23-11-5-7-18-9-6-16-29-24(18)23/h4-17,25H,1-3H3,(H,30,32)/t25-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231079
PNG
(US9340549, 104)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2cc(F)cc(F)c2[nH]c1=O
Show InChI InChI=1S/C24H25F2N3O3/c1-24(2)21(14-6-4-3-5-7-14)29(23(31)32-24)17-10-8-16(9-11-17)28-19-13-15(25)12-18(26)20(19)27-22(28)30/h3-7,12-13,16-17,21H,8-11H2,1-2H3,(H,27,30)/t16-,17-,21-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231090
PNG
(US9340549, 115)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cc(c[nH]c1=O)-c1ccccn1
Show InChI InChI=1S/C27H23N3O3/c1-27(2)24(19-8-4-3-5-9-19)30(26(32)33-27)21-13-11-18(12-14-21)22-16-20(17-29-25(22)31)23-10-6-7-15-28-23/h3-17,24H,1-2H3,(H,29,31)/t24-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231137
PNG
(US9340549, 162)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1cn2ccccc2n1
Show InChI InChI=1S/C25H28N4O3/c1-25(2)22(17-8-4-3-5-9-17)29(24(31)32-25)19-13-11-18(12-14-19)26-23(30)20-16-28-15-7-6-10-21(28)27-20/h3-10,15-16,18-19,22H,11-14H2,1-2H3,(H,26,30)/t18-,19-,22-/m1/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230997
PNG
(US9340549, 15)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-n1c2cnccc2[nH]c1=O
Show InChI InChI=1S/C23H20N4O3/c1-23(2)20(15-6-4-3-5-7-15)27(22(29)30-23)17-10-8-16(9-11-17)26-19-14-24-13-12-18(19)25-21(26)28/h3-14,20H,1-2H3,(H,25,28)/t20-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230998
PNG
(US9340549, 16)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-n1c2ccncc2[nH]c1=O
Show InChI InChI=1S/C23H20N4O3/c1-23(2)20(15-6-4-3-5-7-15)27(22(29)30-23)17-10-8-16(9-11-17)26-19-12-13-24-14-18(19)25-21(26)28/h3-14,20H,1-2H3,(H,25,28)/t20-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231024
PNG
(US9340549, 41)
Show SMILES Cc1ccccc1[C@@H]1N(C(=O)OC1(C)C)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C28H25N3O3/c1-18-8-4-5-11-22(18)25-28(2,3)34-27(33)31(25)21-15-13-20(14-16-21)26(32)30-23-12-6-9-19-10-7-17-29-24(19)23/h4-17,25H,1-3H3,(H,30,32)/t25-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231159
PNG
(US9340549, 179)
Show SMILES C[C@@H]1OC(=O)N(C1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ccc(cc2[nH]c1=O)C#N
Show InChI InChI=1S/C24H24N4O3/c1-15-22(17-5-3-2-4-6-17)28(24(30)31-15)19-10-8-18(9-11-19)27-21-12-7-16(14-25)13-20(21)26-23(27)29/h2-7,12-13,15,18-19,22H,8-11H2,1H3,(H,26,29)/t15-,18-,19-,22?/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231088
PNG
(US9340549, 113)
Show SMILES COc1ccc(cc1)[C@@H]1N(C(=O)OC1(C)C)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C28H25N3O4/c1-28(2)25(19-11-15-22(34-3)16-12-19)31(27(33)35-28)21-13-9-20(10-14-21)26(32)30-23-8-4-6-18-7-5-17-29-24(18)23/h4-17,25H,1-3H3,(H,30,32)/t25-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231133
PNG
(US9340549, 158)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccc[nH]1
Show InChI InChI=1S/C22H27N3O3/c1-22(2)19(15-7-4-3-5-8-15)25(21(27)28-22)17-12-10-16(11-13-17)24-20(26)18-9-6-14-23-18/h3-9,14,16-17,19,23H,10-13H2,1-2H3,(H,24,26)/t16-,17-,19-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231040
PNG
(US9340549, 57)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ncc(cc2[nH]c1=O)C#N
Show InChI InChI=1S/C24H25N5O3/c1-24(2)20(16-6-4-3-5-7-16)28(23(31)32-24)17-8-10-18(11-9-17)29-21-19(27-22(29)30)12-15(13-25)14-26-21/h3-7,12,14,17-18,20H,8-11H2,1-2H3,(H,27,30)/t17-,18-,20-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231093
PNG
(US9340549, 118)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cc(c[nH]c1=O)-c1cccnc1
Show InChI InChI=1S/C27H23N3O3/c1-27(2)24(19-7-4-3-5-8-19)30(26(32)33-27)22-12-10-18(11-13-22)23-15-21(17-29-25(23)31)20-9-6-14-28-16-20/h3-17,24H,1-2H3,(H,29,31)/t24-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231080
PNG
(US9340549, 105)
Show SMILES COc1cccc(c1)C1N(C(=O)OC1(C)C)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C28H25N3O4/c1-28(2)25(20-8-4-10-22(17-20)34-3)31(27(33)35-28)21-14-12-19(13-15-21)26(32)30-23-11-5-7-18-9-6-16-29-24(18)23/h4-17,25H,1-3H3,(H,30,32)
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231091
PNG
(US9340549, 116)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cc(c[nH]c1=O)-c1ncco1
Show InChI InChI=1S/C25H21N3O4/c1-25(2)21(17-6-4-3-5-7-17)28(24(30)32-25)19-10-8-16(9-11-19)20-14-18(15-27-22(20)29)23-26-12-13-31-23/h3-15,21H,1-2H3,(H,27,29)/t21-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231053
PNG
(US9340549, 75)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1cnc(N)c(c1)-c1ncccn1
Show InChI InChI=1S/C26H29N5O2/c1-26(2)22(18-7-4-3-5-8-18)31(25(32)33-26)20-11-9-17(10-12-20)19-15-21(23(27)30-16-19)24-28-13-6-14-29-24/h3-8,13-17,20,22H,9-12H2,1-2H3,(H2,27,30)/t17-,20-,22-/m1/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-2


(Homo sapiens (Human))
BDBM231011
PNG
(US9340549, 28)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1cccc2cccnc12
Show InChI InChI=1S/C27H29N3O3/c1-27(2)24(19-8-4-3-5-9-19)30(26(32)33-27)21-15-13-20(14-16-21)29-25(31)22-12-6-10-18-11-7-17-28-23(18)22/h3-12,17,20-21,24H,13-16H2,1-2H3,(H,29,31)/t20-,21-,24-/m1/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-2


(Homo sapiens (Human))
BDBM50434157
PNG
(CHEMBL2381958 | US9340549, 78)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C27H23N3O3/c1-27(2)24(19-8-4-3-5-9-19)30(26(32)33-27)21-15-13-20(14-16-21)25(31)29-22-12-6-10-18-11-7-17-28-23(18)22/h3-17,24H,1-2H3,(H,29,31)/t24-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231085
PNG
(US9340549, 110)
Show SMILES CC1(C)OC(=O)N([C@H]1c1cccc(F)c1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C27H22FN3O3/c1-27(2)24(19-7-3-9-20(28)16-19)31(26(33)34-27)21-13-11-18(12-14-21)25(32)30-22-10-4-6-17-8-5-15-29-23(17)22/h3-16,24H,1-2H3,(H,30,32)/t24-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231092
PNG
(US9340549, 117)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cc(cnc1F)-c1cccnc1
Show InChI InChI=1S/C27H22FN3O2/c1-27(2)24(19-7-4-3-5-8-19)31(26(32)33-27)22-12-10-18(11-13-22)23-15-21(17-30-25(23)28)20-9-6-14-29-16-20/h3-17,24H,1-2H3/t24-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231059
PNG
(US9340549, 82)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1cc(c[nH]c1=O)-c1ncccn1
Show InChI InChI=1S/C26H28N4O3/c1-26(2)22(18-7-4-3-5-8-18)30(25(32)33-26)20-11-9-17(10-12-20)21-15-19(16-29-24(21)31)23-27-13-6-14-28-23/h3-8,13-17,20,22H,9-12H2,1-2H3,(H,29,31)/t17-,20-,22-/m1/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM50434157
PNG
(CHEMBL2381958 | US9340549, 78)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C27H23N3O3/c1-27(2)24(19-8-4-3-5-9-19)30(26(32)33-27)21-15-13-20(14-16-21)25(31)29-22-12-6-10-18-11-7-17-28-23(18)22/h3-17,24H,1-2H3,(H,29,31)/t24-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231117
PNG
(US9340549, 142)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccncc1
Show InChI InChI=1S/C23H27N3O3/c1-23(2)20(16-6-4-3-5-7-16)26(22(28)29-23)19-10-8-18(9-11-19)25-21(27)17-12-14-24-15-13-17/h3-7,12-15,18-20H,8-11H2,1-2H3,(H,25,27)/t18-,19-,20-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231112
PNG
(US9340549, 137)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)C1CC[C@@H](CC1)c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C24H27N3O2/c1-24(2)21(17-6-4-3-5-7-17)27(23(28)29-24)20-10-8-16(9-11-20)19-14-18-12-13-25-22(18)26-15-19/h3-7,12-16,20-21H,8-11H2,1-2H3,(H,25,26)/t16-,20?,21-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231076
PNG
(US9340549, 100)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cnc(N)c(c1)-c1cc(Cl)cnn1
Show InChI InChI=1S/C26H22ClN5O2/c1-26(2)23(17-6-4-3-5-7-17)32(25(33)34-26)20-10-8-16(9-11-20)18-12-21(24(28)29-14-18)22-13-19(27)15-30-31-22/h3-15,23H,1-2H3,(H2,28,29)/t23-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231138
PNG
(US9340549, 163)
Show SMILES COc1ccccc1C(=O)N[C@H]1CC[C@@H](CC1)N1[C@@H](c2ccccc2)C(C)(C)OC1=O
Show InChI InChI=1S/C25H30N2O4/c1-25(2)22(17-9-5-4-6-10-17)27(24(29)31-25)19-15-13-18(14-16-19)26-23(28)20-11-7-8-12-21(20)30-3/h4-12,18-19,22H,13-16H2,1-3H3,(H,26,28)/t18-,19-,22-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231119
PNG
(US9340549, 144)
Show SMILES Cn1cc2c(cccc2n1)C(=O)N[C@H]1CC[C@@H](CC1)N1[C@H](c2ccccc2)C(C)(C)OC1=O
Show InChI InChI=1S/C26H30N4O3/c1-26(2)23(17-8-5-4-6-9-17)30(25(32)33-26)19-14-12-18(13-15-19)27-24(31)20-10-7-11-22-21(20)16-29(3)28-22/h4-11,16,18-19,23H,12-15H2,1-3H3,(H,27,31)/t18-,19-,23-/m1/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231118
PNG
(US9340549, 143)
Show SMILES Cn1cc(C(=O)N[C@H]2CC[C@@H](CC2)N2[C@@H](c3ccccc3)C(C)(C)OC2=O)c2ccccc12
Show InChI InChI=1S/C27H31N3O3/c1-27(2)24(18-9-5-4-6-10-18)30(26(32)33-27)20-15-13-19(14-16-20)28-25(31)22-17-29(3)23-12-8-7-11-21(22)23/h4-12,17,19-20,24H,13-16H2,1-3H3,(H,28,31)/t19-,20-,24-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231127
PNG
(US9340549, 152)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccnc2[nH]ccc12
Show InChI InChI=1S/C25H28N4O3/c1-25(2)21(16-6-4-3-5-7-16)29(24(31)32-25)18-10-8-17(9-11-18)28-23(30)20-13-15-27-22-19(20)12-14-26-22/h3-7,12-15,17-18,21H,8-11H2,1-2H3,(H,26,27)(H,28,30)/t17-,18-,21-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231098
PNG
(US9340549, 123)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccn1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C26H22N4O3/c1-26(2)23(21-9-3-4-15-27-21)30(25(32)33-26)19-13-11-18(12-14-19)24(31)29-20-10-5-7-17-8-6-16-28-22(17)20/h3-16,23H,1-2H3,(H,29,31)/t23-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231006
PNG
(US9340549, 24)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ccncc2[nH]c1=O
Show InChI InChI=1S/C23H26N4O3/c1-23(2)20(15-6-4-3-5-7-15)27(22(29)30-23)17-10-8-16(9-11-17)26-19-12-13-24-14-18(19)25-21(26)28/h3-7,12-14,16-17,20H,8-11H2,1-2H3,(H,25,28)/t16-,17-,20-/m1/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231140
PNG
(US9340549, 165)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccncn1
Show InChI InChI=1S/C22H26N4O3/c1-22(2)19(15-6-4-3-5-7-15)26(21(28)29-22)17-10-8-16(9-11-17)25-20(27)18-12-13-23-14-24-18/h3-7,12-14,16-17,19H,8-11H2,1-2H3,(H,25,27)/t16-,17-,19-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231025
PNG
(US9340549, 42)
Show SMILES CC1(C)OC(=O)N(C1c1ccccc1F)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C27H22FN3O3/c1-27(2)24(20-9-3-4-10-21(20)28)31(26(33)34-27)19-14-12-18(13-15-19)25(32)30-22-11-5-7-17-8-6-16-29-23(17)22/h3-16,24H,1-2H3,(H,30,32)
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231073
PNG
(US9340549, 97)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1c[nH]c(=O)c(c1)-c1ncccn1
Show InChI InChI=1S/C26H28N4O3/c1-26(2)22(18-7-4-3-5-8-18)30(25(32)33-26)20-11-9-17(10-12-20)19-15-21(24(31)29-16-19)23-27-13-6-14-28-23/h3-8,13-17,20,22H,9-12H2,1-2H3,(H,29,31)/t17-,20-,22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231071
PNG
(US9340549, 94)
Show SMILES C[C@@]1(CN([C@H]2CC[C@@H](CC2)n2c3ccc(cc3[nH]c2=O)C#N)C(=O)O1)c1ccccc1
Show InChI InChI=1S/C24H24N4O3/c1-24(17-5-3-2-4-6-17)15-27(23(30)31-24)18-8-10-19(11-9-18)28-21-12-7-16(14-25)13-20(21)26-22(28)29/h2-7,12-13,18-19H,8-11,15H2,1H3,(H,26,29)/t18-,19-,24-/m1/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231101
PNG
(US9340549, 126)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccncc1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C26H22N4O3/c1-26(2)23(18-12-15-27-16-13-18)30(25(32)33-26)20-10-8-19(9-11-20)24(31)29-21-7-3-5-17-6-4-14-28-22(17)21/h3-16,23H,1-2H3,(H,29,31)/t23-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231102
PNG
(US9340549, 127)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-n1cc(ccc1=O)-c1ncccn1
Show InChI InChI=1S/C26H22N4O3/c1-26(2)23(18-7-4-3-5-8-18)30(25(32)33-26)21-12-10-20(11-13-21)29-17-19(9-14-22(29)31)24-27-15-6-16-28-24/h3-17,23H,1-2H3/t23-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230984
PNG
(US9340549, 2)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccc(F)cc1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C27H22FN3O3/c1-27(2)24(18-8-12-20(28)13-9-18)31(26(33)34-27)21-14-10-19(11-15-21)25(32)30-22-7-3-5-17-6-4-16-29-23(17)22/h3-16,24H,1-2H3,(H,30,32)/t24-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231096
PNG
(US9340549, 121)
Show SMILES CC1(C)OC(=O)N(C1c1ccccn1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C26H22N4O3/c1-26(2)23(21-9-3-4-15-27-21)30(25(32)33-26)19-13-11-18(12-14-19)24(31)29-20-10-5-7-17-8-6-16-28-22(17)20/h3-16,23H,1-2H3,(H,29,31)
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231011
PNG
(US9340549, 28)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1cccc2cccnc12
Show InChI InChI=1S/C27H29N3O3/c1-27(2)24(19-8-4-3-5-9-19)30(26(32)33-27)21-15-13-20(14-16-21)29-25(31)22-12-6-10-18-11-7-17-28-23(18)22/h3-12,17,20-21,24H,13-16H2,1-2H3,(H,29,31)/t20-,21-,24-/m1/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231136
PNG
(US9340549, 161)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C27H30N4O3/c1-27(2)24(19-9-5-3-6-10-19)31(26(33)34-27)23-15-13-21(14-16-23)29-25(32)20-17-28-30(18-20)22-11-7-4-8-12-22/h3-12,17-18,21,23-24H,13-16H2,1-2H3,(H,29,32)/t21-,23-,24-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231052
PNG
(US9340549, 72)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@H](CC1)c1cnc(N)c(c1)-c1ncccn1
Show InChI InChI=1S/C26H29N5O2/c1-26(2)22(18-7-4-3-5-8-18)31(25(32)33-26)20-11-9-17(10-12-20)19-15-21(23(27)30-16-19)24-28-13-6-14-29-24/h3-8,13-17,20,22H,9-12H2,1-2H3,(H2,27,30)/t17-,20+,22-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231014
PNG
(US9340549, 31)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2cccnc2[nH]c1=O
Show InChI InChI=1S/C23H26N4O3/c1-23(2)19(15-7-4-3-5-8-15)27(22(29)30-23)17-12-10-16(11-13-17)26-18-9-6-14-24-20(18)25-21(26)28/h3-9,14,16-17,19H,10-13H2,1-2H3,(H,24,25,28)/t16-,17-,19-/m1/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230985
PNG
(US9340549, 3)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cc(cnc1F)-c1ncccn1
Show InChI InChI=1S/C26H21FN4O2/c1-26(2)22(18-7-4-3-5-8-18)31(25(32)33-26)20-11-9-17(10-12-20)21-15-19(16-30-23(21)27)24-28-13-6-14-29-24/h3-16,22H,1-2H3/t22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230993
PNG
(US9340549, 11)
Show SMILES CC1(C)OC(=O)N([C@H]1c1cccnc1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C26H22N4O3/c1-26(2)23(19-8-4-14-27-16-19)30(25(32)33-26)20-12-10-18(11-13-20)24(31)29-21-9-3-6-17-7-5-15-28-22(17)21/h3-16,23H,1-2H3,(H,29,31)/t23-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231089
PNG
(US9340549, 114)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cc(cnc1F)-c1ccccn1
Show InChI InChI=1S/C27H22FN3O2/c1-27(2)24(19-8-4-3-5-9-19)31(26(32)33-27)21-13-11-18(12-14-21)22-16-20(17-30-25(22)28)23-10-6-7-15-29-23/h3-17,24H,1-2H3/t24-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231022
PNG
(US9340549, 39)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ccncc2n(CC(F)F)c1=O
Show InChI InChI=1S/C25H28F2N4O3/c1-25(2)22(16-6-4-3-5-7-16)31(24(33)34-25)18-10-8-17(9-11-18)30-19-12-13-28-14-20(19)29(23(30)32)15-21(26)27/h3-7,12-14,17-18,21-22H,8-11,15H2,1-2H3/t17-,18-,22-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231021
PNG
(US9340549, 38)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ncccc2[nH]c1=O
Show InChI InChI=1S/C23H26N4O3/c1-23(2)19(15-7-4-3-5-8-15)26(22(29)30-23)16-10-12-17(13-11-16)27-20-18(25-21(27)28)9-6-14-24-20/h3-9,14,16-17,19H,10-13H2,1-2H3,(H,25,28)/t16-,17-,19-/m1/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231061
PNG
(US9340549, 84)
Show SMILES CC1(C)OC(=O)N(C1c1ccccc1)[C@H]1CC[C@@H](CC1)c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C25H27N3O3/c1-25(2)21(17-9-5-3-6-10-17)28(24(29)31-25)20-15-13-19(14-16-20)23-27-26-22(30-23)18-11-7-4-8-12-18/h3-12,19-21H,13-16H2,1-2H3/t19-,20-,21?
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231051
PNG
(US9340549, 71)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccn2c(Nc3ccnc4cccnc34)nnc2c1
Show InChI InChI=1S/C25H21N7O2/c1-25(2)22(16-7-4-3-5-8-16)32(24(33)34-25)17-11-14-31-20(15-17)29-30-23(31)28-19-10-13-26-18-9-6-12-27-21(18)19/h3-15,22H,1-2H3,(H,26,28,30)/t22-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231072
PNG
(US9340549, 96)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@H](CC1)c1c[nH]c(=O)c(c1)-c1ncccn1
Show InChI InChI=1S/C26H28N4O3/c1-26(2)22(18-7-4-3-5-8-18)30(25(32)33-26)20-11-9-17(10-12-20)19-15-21(24(31)29-16-19)23-27-13-6-14-28-23/h3-8,13-17,20,22H,9-12H2,1-2H3,(H,29,31)/t17-,20+,22-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231130
PNG
(US9340549, 155)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1cnc2ccccc2c1
Show InChI InChI=1S/C27H29N3O3/c1-27(2)24(18-8-4-3-5-9-18)30(26(32)33-27)22-14-12-21(13-15-22)29-25(31)20-16-19-10-6-7-11-23(19)28-17-20/h3-11,16-17,21-22,24H,12-15H2,1-2H3,(H,29,31)/t21-,22-,24-/m1/s1
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The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231083
PNG
(US9340549, 108)
Show SMILES CC1(C)OC(=O)N(C1c1cccc(F)c1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C27H22FN3O3/c1-27(2)24(19-7-3-9-20(28)16-19)31(26(33)34-27)21-13-11-18(12-14-21)25(32)30-22-10-4-6-17-8-5-15-29-23(17)22/h3-16,24H,1-2H3,(H,30,32)
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231031
PNG
(US9340549, 48)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)N1C(=O)C(F)(F)c2ccccc12
Show InChI InChI=1S/C25H26F2N2O3/c1-24(2)21(16-8-4-3-5-9-16)29(23(31)32-24)18-14-12-17(13-15-18)28-20-11-7-6-10-19(20)25(26,27)22(28)30/h3-11,17-18,21H,12-15H2,1-2H3/t17-,18-,21-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231023
PNG
(US9340549, 40)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cc(cnn1)-c1ccccn1
Show InChI InChI=1S/C26H22N4O2/c1-26(2)24(19-8-4-3-5-9-19)30(25(31)32-26)21-13-11-18(12-14-21)23-16-20(17-28-29-23)22-10-6-7-15-27-22/h3-17,24H,1-2H3/t24-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231086
PNG
(US9340549, 111)
Show SMILES COc1ccc(cc1)C1N(C(=O)OC1(C)C)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C28H25N3O4/c1-28(2)25(19-11-15-22(34-3)16-12-19)31(27(33)35-28)21-13-9-20(10-14-21)26(32)30-23-8-4-6-18-7-5-17-29-24(18)23/h4-17,25H,1-3H3,(H,30,32)
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231103
PNG
(US9340549, 128)
Show SMILES Cc1cc(ccc1C(=O)Nc1ccnc2cccnc12)N1[C@@H](c2ccccc2)C(C)(C)OC1=O
Show InChI InChI=1S/C27H24N4O3/c1-17-16-19(31-24(18-8-5-4-6-9-18)27(2,3)34-26(31)33)11-12-20(17)25(32)30-22-13-15-28-21-10-7-14-29-23(21)22/h4-16,24H,1-3H3,(H,28,30,32)/t24-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231161
PNG
(US9340549, 181)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1ncc2cc(ccc12)C#N
Show InChI InChI=1S/C25H26N4O2/c1-25(2)23(18-6-4-3-5-7-18)28(24(30)31-25)20-9-11-21(12-10-20)29-22-13-8-17(15-26)14-19(22)16-27-29/h3-8,13-14,16,20-21,23H,9-12H2,1-2H3/t20-,21-,23-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231116
PNG
(US9340549, 141)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccccc1
Show InChI InChI=1S/C24H28N2O3/c1-24(2)21(17-9-5-3-6-10-17)26(23(28)29-24)20-15-13-19(14-16-20)25-22(27)18-11-7-4-8-12-18/h3-12,19-21H,13-16H2,1-2H3,(H,25,27)/t19-,20-,21-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231099
PNG
(US9340549, 124)
Show SMILES CC1(C)OC(=O)N(C1c1ccncc1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C26H22N4O3/c1-26(2)23(18-12-15-27-16-13-18)30(25(32)33-26)20-10-8-19(9-11-20)24(31)29-21-7-3-5-17-6-4-14-28-22(17)21/h3-16,23H,1-2H3,(H,29,31)
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231067
PNG
(US9340549, 90)
Show SMILES C[C@]1(CN([C@H]2CC[C@@H](CC2)n2c3ccncc3[nH]c2=O)C(=O)O1)c1ccccc1
Show InChI InChI=1S/C22H24N4O3/c1-22(15-5-3-2-4-6-15)14-25(21(28)29-22)16-7-9-17(10-8-16)26-19-11-12-23-13-18(19)24-20(26)27/h2-6,11-13,16-17H,7-10,14H2,1H3,(H,24,27)/t16-,17-,22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231105
PNG
(US9340549, 130)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1cc(c[nH]c1=O)C1=NCCCN1
Show InChI InChI=1S/C26H32N4O3/c1-26(2)22(18-7-4-3-5-8-18)30(25(32)33-26)20-11-9-17(10-12-20)21-15-19(16-29-24(21)31)23-27-13-6-14-28-23/h3-5,7-8,15-17,20,22H,6,9-14H2,1-2H3,(H,27,28)(H,29,31)/t17-,20-,22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231026
PNG
(US9340549, 43)
Show SMILES CCC1(CC)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C29H27N3O3/c1-3-29(4-2)26(21-10-6-5-7-11-21)32(28(34)35-29)23-17-15-22(16-18-23)27(33)31-24-14-8-12-20-13-9-19-30-25(20)24/h5-19,26H,3-4H2,1-2H3,(H,31,33)/t26-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231027
PNG
(US9340549, 44)
Show SMILES O=C(Nc1cccc2cccnc12)c1ccc(cc1)N1C(c2ccccc2)C2(CCC2)OC1=O
Show InChI InChI=1S/C28H23N3O3/c32-26(30-23-11-4-9-19-10-5-18-29-24(19)23)21-12-14-22(15-13-21)31-25(20-7-2-1-3-8-20)28(16-6-17-28)34-27(31)33/h1-5,7-15,18,25H,6,16-17H2,(H,30,32)
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231128
PNG
(US9340549, 153)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1cccc2[nH]ncc12
Show InChI InChI=1S/C25H28N4O3/c1-25(2)22(16-7-4-3-5-8-16)29(24(31)32-25)18-13-11-17(12-14-18)27-23(30)19-9-6-10-21-20(19)15-26-28-21/h3-10,15,17-18,22H,11-14H2,1-2H3,(H,26,28)(H,27,30)/t17-,18-,22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231001
PNG
(US9340549, 19)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C24H21N3O3/c1-24(2)21(16-8-4-3-5-9-16)27(23(29)30-24)18-14-12-17(13-15-18)26-20-11-7-6-10-19(20)25-22(26)28/h3-15,21H,1-2H3,(H,25,28)/t21-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231160
PNG
(US9340549, 180)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1ncc2cc(ccc12)C#N
Show InChI InChI=1S/C25H26N4O2/c1-25(2)23(18-6-4-3-5-7-18)28(24(30)31-25)20-9-11-21(12-10-20)29-22-13-8-17(15-26)14-19(22)16-27-29/h3-8,13-14,16,20-21,23H,9-12H2,1-2H3/t20-,21-,23-/m1/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231078
PNG
(US9340549, 102)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cnc(N)c(c1)-c1nccc(n1)C#N
Show InChI InChI=1S/C27H22N6O2/c1-27(2)23(18-6-4-3-5-7-18)33(26(34)35-27)21-10-8-17(9-11-21)19-14-22(24(29)31-16-19)25-30-13-12-20(15-28)32-25/h3-14,16,23H,1-2H3,(H2,29,31)/t23-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231000
PNG
(US9340549, 18)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)N1C(=O)Cc2ccccc12
Show InChI InChI=1S/C25H22N2O3/c1-25(2)23(17-8-4-3-5-9-17)27(24(29)30-25)20-14-12-19(13-15-20)26-21-11-7-6-10-18(21)16-22(26)28/h3-15,23H,16H2,1-2H3/t23-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231157
PNG
(US9340549, 177)
Show SMILES CC1(C)OC(=O)N([C@H]2CC(C2)c2nnc(o2)-c2ccccc2)[C@H]1c1ccccc1
Show InChI InChI=1S/C23H23N3O3/c1-23(2)19(15-9-5-3-6-10-15)26(22(27)29-23)18-13-17(14-18)21-25-24-20(28-21)16-11-7-4-8-12-16/h3-12,17-19H,13-14H2,1-2H3/t17?,18-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230991
PNG
(US9340549, 9)
Show SMILES CC1(C)OC(=O)N(C1c1cccnc1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C26H22N4O3/c1-26(2)23(19-8-4-14-27-16-19)30(25(32)33-26)20-12-10-18(11-13-20)24(31)29-21-9-3-6-17-7-5-15-28-22(17)21/h3-16,23H,1-2H3,(H,29,31)
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231149
PNG
(US9340549, 172)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@H](CC1)c1cnc2cc[nH]c2c1
Show InChI InChI=1S/C24H27N3O2/c1-24(2)22(17-6-4-3-5-7-17)27(23(28)29-24)19-10-8-16(9-11-19)18-14-21-20(26-15-18)12-13-25-21/h3-7,12-16,19,22,25H,8-11H2,1-2H3/t16-,19+,22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231028
PNG
(US9340549, 45)
Show SMILES O=C(Nc1cccc2cccnc12)c1ccc(cc1)N1C(c2ccccc2)C2(CCCC2)OC1=O
Show InChI InChI=1S/C29H25N3O3/c33-27(31-24-12-6-10-20-11-7-19-30-25(20)24)22-13-15-23(16-14-22)32-26(21-8-2-1-3-9-21)29(35-28(32)34)17-4-5-18-29/h1-3,6-16,19,26H,4-5,17-18H2,(H,31,33)
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231113
PNG
(US9340549, 138)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)C1CC[C@@H](CC1)c1cc2ccncc2[nH]c1=O
Show InChI InChI=1S/C25H27N3O3/c1-25(2)22(17-6-4-3-5-7-17)28(24(30)31-25)19-10-8-16(9-11-19)20-14-18-12-13-26-15-21(18)27-23(20)29/h3-7,12-16,19,22H,8-11H2,1-2H3,(H,27,29)/t16-,19?,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231003
PNG
(US9340549, 21)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)C(=O)Nc1cnccc1O
Show InChI InChI=1S/C23H21N3O4/c1-23(2)20(15-6-4-3-5-7-15)26(22(29)30-23)17-10-8-16(9-11-17)21(28)25-18-14-24-13-12-19(18)27/h3-14,20H,1-2H3,(H,24,27)(H,25,28)/t20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231094
PNG
(US9340549, 119)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1ccc[nH]c1=O
Show InChI InChI=1S/C22H20N2O3/c1-22(2)19(16-7-4-3-5-8-16)24(21(26)27-22)17-12-10-15(11-13-17)18-9-6-14-23-20(18)25/h3-14,19H,1-2H3,(H,23,25)/t19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231110
PNG
(US9340549, 135)
Show SMILES Cc1ccc(cn1)[C@H]1CCC(CC1)N1[C@@H](c2ccccc2)C(C)(C)OC1=O
Show InChI InChI=1S/C23H28N2O2/c1-16-9-10-19(15-24-16)17-11-13-20(14-12-17)25-21(18-7-5-4-6-8-18)23(2,3)27-22(25)26/h4-10,15,17,20-21H,11-14H2,1-3H3/t17-,20?,21-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231108
PNG
(US9340549, 133)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)C1CC[C@@H](CC1)c1cccnc1
Show InChI InChI=1S/C22H26N2O2/c1-22(2)20(17-7-4-3-5-8-17)24(21(25)26-22)19-12-10-16(11-13-19)18-9-6-14-23-15-18/h3-9,14-16,19-20H,10-13H2,1-2H3/t16-,19?,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231004
PNG
(US9340549, 22)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(nc1)-n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C23H20N4O3/c1-23(2)20(15-8-4-3-5-9-15)26(22(29)30-23)16-12-13-19(24-14-16)27-18-11-7-6-10-17(18)25-21(27)28/h3-14,20H,1-2H3,(H,25,28)/t20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231135
PNG
(US9340549, 160)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1nccs1
Show InChI InChI=1S/C21H25N3O3S/c1-21(2)17(14-6-4-3-5-7-14)24(20(26)27-21)16-10-8-15(9-11-16)23-18(25)19-22-12-13-28-19/h3-7,12-13,15-17H,8-11H2,1-2H3,(H,23,25)/t15-,16-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231154
PNG
(US9340549, 175 | US9340549, 176)
Show SMILES CC1(C)OC(=O)N([C@H]2CC(C2)c2nnc(o2)-c2ccccc2)[C@@H]1c1ccccc1
Show InChI InChI=1S/C23H23N3O3/c1-23(2)19(15-9-5-3-6-10-15)26(22(27)29-23)18-13-17(14-18)21-25-24-20(28-21)16-11-7-4-8-12-16/h3-12,17-19H,13-14H2,1-2H3/t17?,18-,19-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231002
PNG
(US9340549, 20)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)C(=O)Nc1nccc2cccnc12
Show InChI InChI=1S/C26H22N4O3/c1-26(2)22(18-7-4-3-5-8-18)30(25(32)33-26)20-12-10-19(11-13-20)24(31)29-23-21-17(14-16-28-23)9-6-15-27-21/h3-16,22H,1-2H3,(H,28,29,31)/t22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231050
PNG
(US9340549, 70)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H20N4O2/c1-21(2)18(15-6-4-3-5-7-15)25(20(26)27-21)17-10-8-14(9-11-17)16-12-23-19(22)24-13-16/h3-13,18H,1-2H3,(H2,22,23,24)/t18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231097
PNG
(US9340549, 122)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccccn1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C26H22N4O3/c1-26(2)23(21-9-3-4-15-27-21)30(25(32)33-26)19-13-11-18(12-14-19)24(31)29-20-10-5-7-17-8-6-16-28-22(17)20/h3-16,23H,1-2H3,(H,29,31)/t23-/m1/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231125
PNG
(US9340549, 150)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2scnc2c1
Show InChI InChI=1S/C25H27N3O3S/c1-25(2)22(16-6-4-3-5-7-16)28(24(30)31-25)19-11-9-18(10-12-19)27-23(29)17-8-13-21-20(14-17)26-15-32-21/h3-8,13-15,18-19,22H,9-12H2,1-2H3,(H,27,29)/t18-,19-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231134
PNG
(US9340549, 159)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2nccn2c1
Show InChI InChI=1S/C25H28N4O3/c1-25(2)22(17-6-4-3-5-7-17)29(24(31)32-25)20-11-9-19(10-12-20)27-23(30)18-8-13-21-26-14-15-28(21)16-18/h3-8,13-16,19-20,22H,9-12H2,1-2H3,(H,27,30)/t19-,20-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231055
PNG
(US9340549, 77)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1cnc(N)c(c1)C1=NCCCN1
Show InChI InChI=1S/C26H33N5O2/c1-26(2)22(18-7-4-3-5-8-18)31(25(32)33-26)20-11-9-17(10-12-20)19-15-21(23(27)30-16-19)24-28-13-6-14-29-24/h3-5,7-8,15-17,20,22H,6,9-14H2,1-2H3,(H2,27,30)(H,28,29)/t17-,20-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231104
PNG
(US9340549, 129)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1cc(ncc1F)-c1ncccn1
Show InChI InChI=1S/C26H21FN4O2/c1-26(2)23(18-7-4-3-5-8-18)31(25(32)33-26)19-11-9-17(10-12-19)20-15-22(30-16-21(20)27)24-28-13-6-14-29-24/h3-16,23H,1-2H3/t23-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231081
PNG
(US9340549, 106)
Show SMILES COc1cccc(c1)[C@H]1N(C(=O)OC1(C)C)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C28H25N3O4/c1-28(2)25(20-8-4-10-22(17-20)34-3)31(27(33)35-28)21-14-12-19(13-15-21)26(32)30-23-11-5-7-18-9-6-16-29-24(18)23/h4-17,25H,1-3H3,(H,30,32)/t25-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231046
PNG
(US9340549, 66)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1nnc2cc(ccn12)-c1cncnc1
Show InChI InChI=1S/C27H22N6O2/c1-27(2)24(18-6-4-3-5-7-18)33(26(34)35-27)22-10-8-19(9-11-22)25-31-30-23-14-20(12-13-32(23)25)21-15-28-17-29-16-21/h3-17,24H,1-2H3/t24-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231048
PNG
(US9340549, 68)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1nnc2ccc(Cl)nn12
Show InChI InChI=1S/C22H18ClN5O2/c1-22(2)19(14-6-4-3-5-7-14)27(21(29)30-22)16-10-8-15(9-11-16)20-25-24-18-13-12-17(23)26-28(18)20/h3-13,19H,1-2H3/t19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230995
PNG
(US9340549, 13)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1cnc(N)c(Nc2ncccn2)c1
Show InChI InChI=1S/C26H30N6O2/c1-26(2)22(18-7-4-3-5-8-18)32(25(33)34-26)20-11-9-17(10-12-20)19-15-21(23(27)30-16-19)31-24-28-13-6-14-29-24/h3-8,13-17,20,22H,9-12H2,1-2H3,(H2,27,30)(H,28,29,31)/t17-,20-,22-/m1/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231049
PNG
(US9340549, 69)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-n1nnc2ccccc12
Show InChI InChI=1S/C23H20N4O2/c1-23(2)21(16-8-4-3-5-9-16)26(22(28)29-23)17-12-14-18(15-13-17)27-20-11-7-6-10-19(20)24-25-27/h3-15,21H,1-2H3/t21-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231129
PNG
(US9340549, 154)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N[C@H]1CC[C@@H](CC1)N1[C@@H](c2ccccc2)C(C)(C)OC1=O
Show InChI InChI=1S/C24H32N4O3/c1-15(2)19-14-20(27-26-19)22(29)25-17-10-12-18(13-11-17)28-21(16-8-6-5-7-9-16)24(3,4)31-23(28)30/h5-9,14-15,17-18,21H,10-13H2,1-4H3,(H,25,29)(H,26,27)/t17-,18-,21-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231087
PNG
(US9340549, 112)
Show SMILES COc1ccc(cc1)[C@H]1N(C(=O)OC1(C)C)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C28H25N3O4/c1-28(2)25(19-11-15-22(34-3)16-12-19)31(27(33)35-28)21-13-9-20(10-14-21)26(32)30-23-8-4-6-18-7-5-17-29-24(18)23/h4-17,25H,1-3H3,(H,30,32)/t25-/m1/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230999
PNG
(US9340549, 17)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-n1c2ccccc2oc1=O
Show InChI InChI=1S/C24H20N2O4/c1-24(2)21(16-8-4-3-5-9-16)26(23(28)30-24)18-14-12-17(13-15-18)25-19-10-6-7-11-20(19)29-22(25)27/h3-15,21H,1-2H3/t21-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231057
PNG
(US9340549, 80)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-n1cc([nH]c1=O)-c1ccccc1
Show InChI InChI=1S/C26H23N3O3/c1-26(2)23(19-11-7-4-8-12-19)29(25(31)32-26)21-15-13-20(14-16-21)28-17-22(27-24(28)30)18-9-5-3-6-10-18/h3-17,23H,1-2H3,(H,27,30)/t23-/m0/s1
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n/an/a 3.08E+3n/an/an/an/an/an/a



AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231154
PNG
(US9340549, 175 | US9340549, 176)
Show SMILES CC1(C)OC(=O)N([C@H]2CC(C2)c2nnc(o2)-c2ccccc2)[C@@H]1c1ccccc1
Show InChI InChI=1S/C23H23N3O3/c1-23(2)19(15-9-5-3-6-10-15)26(22(27)29-23)18-13-17(14-18)21-25-24-20(28-21)16-11-7-4-8-12-16/h3-12,17-19H,13-14H2,1-2H3/t17?,18-,19-/m1/s1
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n/an/a 3.13E+3n/an/an/an/an/an/a



AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231032
PNG
(US9340549, 49)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2ccccc2oc1=O
Show InChI InChI=1S/C24H26N2O4/c1-24(2)21(16-8-4-3-5-9-16)26(23(28)30-24)18-14-12-17(13-15-18)25-19-10-6-7-11-20(19)29-22(25)27/h3-11,17-18,21H,12-15H2,1-2H3/t17-,18-,21-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230992
PNG
(US9340549, 10)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1cccnc1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C26H22N4O3/c1-26(2)23(19-8-4-14-27-16-19)30(25(32)33-26)20-12-10-18(11-13-20)24(31)29-21-9-3-6-17-7-5-15-28-22(17)21/h3-16,23H,1-2H3,(H,29,31)/t23-/m1/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231029
PNG
(US9340549, 46)
Show SMILES O=C(Nc1cccc2cccnc12)c1ccc(cc1)N1C(c2ccccc2)C2(CCCCC2)OC1=O
Show InChI InChI=1S/C30H27N3O3/c34-28(32-25-13-7-11-21-12-8-20-31-26(21)25)23-14-16-24(17-15-23)33-27(22-9-3-1-4-10-22)30(36-29(33)35)18-5-2-6-19-30/h1,3-4,7-17,20,27H,2,5-6,18-19H2,(H,32,34)
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231016
PNG
(US9340549, 33)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@H](CC1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C27H29N3O3/c1-27(2)24(19-8-4-3-5-9-19)30(26(32)33-27)21-15-13-20(14-16-21)25(31)29-22-12-6-10-18-11-7-17-28-23(18)22/h3-12,17,20-21,24H,13-16H2,1-2H3,(H,29,31)/t20-,21+,24-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231047
PNG
(US9340549, 67)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)-c1nnc2cc(ccn12)C#N
Show InChI InChI=1S/C24H19N5O2/c1-24(2)21(17-6-4-3-5-7-17)29(23(30)31-24)19-10-8-18(9-11-19)22-27-26-20-14-16(15-25)12-13-28(20)22/h3-14,21H,1-2H3/t21-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231084
PNG
(US9340549, 109)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1cccc(F)c1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C27H22FN3O3/c1-27(2)24(19-7-3-9-20(28)16-19)31(26(33)34-27)21-13-11-18(12-14-21)25(32)30-22-10-4-6-17-8-5-15-29-23(17)22/h3-16,24H,1-2H3,(H,30,32)/t24-/m1/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231056
PNG
(US9340549, 79)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccccc1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C27H23N3O3/c1-27(2)24(19-8-4-3-5-9-19)30(26(32)33-27)21-15-13-20(14-16-21)25(31)29-22-12-6-10-18-11-7-17-28-23(18)22/h3-17,24H,1-2H3,(H,29,31)/t24-/m1/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231044
PNG
(US9340549, 63)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc2C(=O)N(CCc2c1)c1cccc2cccnc12
Show InChI InChI=1S/C29H25N3O3/c1-29(2)26(20-8-4-3-5-9-20)32(28(34)35-29)22-13-14-23-21(18-22)15-17-31(27(23)33)24-12-6-10-19-11-7-16-30-25(19)24/h3-14,16,18,26H,15,17H2,1-2H3/t26-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231100
PNG
(US9340549, 125)
Show SMILES CC1(C)OC(=O)N([C@@H]1c1ccncc1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C26H22N4O3/c1-26(2)23(18-12-15-27-16-13-18)30(25(32)33-26)20-10-8-19(9-11-20)24(31)29-21-7-3-5-17-6-4-14-28-22(17)21/h3-16,23H,1-2H3,(H,29,31)/t23-/m1/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231054
PNG
(US9340549, 76)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@H](CC1)c1cnc(N)c(c1)C1=NCCCN1
Show InChI InChI=1S/C26H33N5O2/c1-26(2)22(18-7-4-3-5-8-18)31(25(32)33-26)20-11-9-17(10-12-20)19-15-21(23(27)30-16-19)24-28-13-6-14-29-24/h3-5,7-8,15-17,20,22H,6,9-14H2,1-2H3,(H2,27,30)(H,28,29)/t17-,20+,22-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM230990
PNG
(US9340549, 8)
Show SMILES CC1(C)OC(=O)N(C1c1ccccc1)c1ccc(cc1)-c1cc(c[nH]c1=O)-c1ncccn1
Show InChI InChI=1S/C26H22N4O3/c1-26(2)22(18-7-4-3-5-8-18)30(25(32)33-26)20-11-9-17(10-12-20)21-15-19(16-29-24(21)31)23-27-13-6-14-28-23/h3-16,22H,1-2H3,(H,29,31)
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231126
PNG
(US9340549, 151)
Show SMILES Cn1cncc1C(=O)N[C@H]1CC[C@@H](CC1)N1[C@@H](c2ccccc2)C(C)(C)OC1=O
Show InChI InChI=1S/C22H28N4O3/c1-22(2)19(15-7-5-4-6-8-15)26(21(28)29-22)17-11-9-16(10-12-17)24-20(27)18-13-23-14-25(18)3/h4-8,13-14,16-17,19H,9-12H2,1-3H3,(H,24,27)/t16-,17-,19-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231141
PNG
(US9340549, 166)
Show SMILES Cc1nc(cs1)C(=O)N[C@H]1CC[C@@H](CC1)N1[C@@H](c2ccccc2)C(C)(C)OC1=O
Show InChI InChI=1S/C22H27N3O3S/c1-14-23-18(13-29-14)20(26)24-16-9-11-17(12-10-16)25-19(15-7-5-4-6-8-15)22(2,3)28-21(25)27/h4-8,13,16-17,19H,9-12H2,1-3H3,(H,24,26)/t16-,17-,19-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231143
PNG
(US9340549, 168)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1cscn1
Show InChI InChI=1S/C21H25N3O3S/c1-21(2)18(14-6-4-3-5-7-14)24(20(26)27-21)16-10-8-15(9-11-16)23-19(25)17-12-28-13-22-17/h3-7,12-13,15-16,18H,8-11H2,1-2H3,(H,23,25)/t15-,16-,18-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


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More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231109
PNG
(US9340549, 134)
Show SMILES Cc1ccc(cn1)[C@H]1CCC(CC1)N1[C@@H](c2ccccc2)C(C)(C)OC1=O
Show InChI InChI=1S/C23H28N2O2/c1-16-9-10-19(15-24-16)17-11-13-20(14-12-17)25-21(18-7-5-4-6-8-18)23(2,3)27-22(25)26/h4-10,15,17,20-21H,11-14H2,1-3H3/t17-,20?,21-/m0/s1
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AMGEN INC.

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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
Tankyrase-1


(Homo sapiens (Human))
BDBM231142
PNG
(US9340549, 167)
Show SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1csc(n1)-c1ccncc1
Show InChI InChI=1S/C26H28N4O3S/c1-26(2)22(17-6-4-3-5-7-17)30(25(32)33-26)20-10-8-19(9-11-20)28-23(31)21-16-34-24(29-21)18-12-14-27-15-13-18/h3-7,12-16,19-20,22H,8-11H2,1-2H3,(H,28,31)/t19-,20-,22-/m0/s1
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Assay Description
The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%