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Patent code US9340555

Compile Data Set for Download or QSAR
Found 180 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228536
PNG
(US9340555, 19)
Show SMILES COC(=O)CN(CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1)CC(=O)OC
Show InChI InChI=1S/C31H32FN5O7S/c1-19-5-10-22(32)23(15-19)36-31(41)35-20-6-8-21(9-7-20)44-25-11-13-33-24-16-26(45-29(24)25)30(40)34-12-4-14-37(17-27(38)42-2)18-28(39)43-3/h5-11,13,15-16H,4,12,14,17-18H2,1-3H3,(H,34,40)(H2,35,36,41)
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n/an/a 0.300n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228535
PNG
(US9340555, 18)
Show SMILES COC(=O)CNCCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C28H28FN5O5S/c1-17-4-9-20(29)21(14-17)34-28(37)33-18-5-7-19(8-6-18)39-23-10-13-31-22-15-24(40-26(22)23)27(36)32-12-3-11-30-16-25(35)38-2/h4-10,13-15,30H,3,11-12,16H2,1-2H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228550
PNG
(US9340555, 37)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCOC(CO)C3)cc2F)c1
Show InChI InChI=1S/C30H31F2N5O5S/c1-18-3-5-21(31)24(13-18)36-30(40)35-23-6-4-19(14-22(23)32)42-26-7-9-33-25-15-27(43-28(25)26)29(39)34-8-2-10-37-11-12-41-20(16-37)17-38/h3-7,9,13-15,20,38H,2,8,10-12,16-17H2,1H3,(H,34,39)(H2,35,36,40)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228564
PNG
(US9340555, 57)
Show SMILES CCOC(=O)CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C28H26F2N4O5S/c1-3-38-25(35)5-4-11-32-27(36)24-15-22-26(40-24)23(10-12-31-22)39-17-7-9-20(19(30)14-17)33-28(37)34-21-13-16(2)6-8-18(21)29/h6-10,12-15H,3-5,11H2,1-2H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228521
PNG
(US9340555, F1)
Show SMILES COC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C23H18FN3O4S/c1-13-3-8-16(24)17(11-13)27-23(29)26-14-4-6-15(7-5-14)31-19-9-10-25-18-12-20(22(28)30-2)32-21(18)19/h3-12H,1-2H3,(H2,26,27,29)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228570
PNG
(US9340555, 67)
Show SMILES CN1CCN(CCCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)cc4)c3s2)CC1
Show InChI InChI=1S/C30H33FN6O3S/c1-20-4-9-23(31)24(18-20)35-30(39)34-21-5-7-22(8-6-21)40-26-10-12-32-25-19-27(41-28(25)26)29(38)33-11-3-13-37-16-14-36(2)15-17-37/h4-10,12,18-19H,3,11,13-17H2,1-2H3,(H,33,38)(H2,34,35,39)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228570
PNG
(US9340555, 67)
Show SMILES CN1CCN(CCCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)cc4)c3s2)CC1
Show InChI InChI=1S/C30H33FN6O3S/c1-20-4-9-23(31)24(18-20)35-30(39)34-21-5-7-22(8-6-21)40-26-10-12-32-25-19-27(41-28(25)26)29(38)33-11-3-13-37-16-14-36(2)15-17-37/h4-10,12,18-19H,3,11,13-17H2,1-2H3,(H,33,38)(H2,34,35,39)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228566
PNG
(US9340555, 61)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)N=S(C)(C)=O)cc2)c1
Show InChI InChI=1S/C24H21FN4O4S2/c1-14-4-9-17(25)18(12-14)28-24(31)27-15-5-7-16(8-6-15)33-20-10-11-26-19-13-21(34-22(19)20)23(30)29-35(2,3)32/h4-13H,1-3H3,(H2,27,28,31)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228552
PNG
(US9340555, 39)
Show SMILES COC(=O)[C@@H]1C[C@@H](O)CN1CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C31H31F2N5O6S/c1-17-4-6-20(32)23(12-17)37-31(42)36-22-7-5-19(14-21(22)33)44-26-8-10-34-24-15-27(45-28(24)26)29(40)35-9-3-11-38-16-18(39)13-25(38)30(41)43-2/h4-8,10,12,14-15,18,25,39H,3,9,11,13,16H2,1-2H3,(H,35,40)(H2,36,37,42)/t18-,25+/m1/s1
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228568
PNG
(US9340555, 65)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCC(O)=O)cc2)c1
Show InChI InChI=1S/C26H23FN4O5S/c1-15-4-9-18(27)19(13-15)31-26(35)30-16-5-7-17(8-6-16)36-21-10-12-28-20-14-22(37-24(20)21)25(34)29-11-2-3-23(32)33/h4-10,12-14H,2-3,11H2,1H3,(H,29,34)(H,32,33)(H2,30,31,35)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228532
PNG
(US9340555, 15)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCCC(CO)C3)cc2)c1
Show InChI InChI=1S/C31H34FN5O4S/c1-20-5-10-24(32)25(16-20)36-31(40)35-22-6-8-23(9-7-22)41-27-11-13-33-26-17-28(42-29(26)27)30(39)34-12-3-15-37-14-2-4-21(18-37)19-38/h5-11,13,16-17,21,38H,2-4,12,14-15,18-19H2,1H3,(H,34,39)(H2,35,36,40)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228548
PNG
(US9340555, 34)
Show SMILES CN1CCN(CCCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)c(F)c4)c3s2)CC1
Show InChI InChI=1S/C30H32F2N6O3S/c1-19-4-6-21(31)24(16-19)36-30(40)35-23-7-5-20(17-22(23)32)41-26-8-10-33-25-18-27(42-28(25)26)29(39)34-9-3-11-38-14-12-37(2)13-15-38/h4-8,10,16-18H,3,9,11-15H2,1-2H3,(H,34,39)(H2,35,36,40)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228554
PNG
(US9340555, 43)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCCC3)cc2F)c1
Show InChI InChI=1S/C29H29F2N5O3S/c1-18-5-7-20(30)23(15-18)35-29(38)34-22-8-6-19(16-21(22)31)39-25-9-11-32-24-17-26(40-27(24)25)28(37)33-10-4-14-36-12-2-3-13-36/h5-9,11,15-17H,2-4,10,12-14H2,1H3,(H,33,37)(H2,34,35,38)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228573
PNG
(US9340555, 70)
Show SMILES CCN(CC)CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C29H32FN5O3S/c1-4-35(5-2)16-6-14-32-28(36)26-18-24-27(39-26)25(13-15-31-24)38-21-10-8-20(9-11-21)33-29(37)34-23-17-19(3)7-12-22(23)30/h7-13,15,17-18H,4-6,14,16H2,1-3H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228532
PNG
(US9340555, 15)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCCC(CO)C3)cc2)c1
Show InChI InChI=1S/C31H34FN5O4S/c1-20-5-10-24(32)25(16-20)36-31(40)35-22-6-8-23(9-7-22)41-27-11-13-33-26-17-28(42-29(26)27)30(39)34-12-3-15-37-14-2-4-21(18-37)19-38/h5-11,13,16-17,21,38H,2-4,12,14-15,18-19H2,1H3,(H,34,39)(H2,35,36,40)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228529
PNG
(US9340555, 12)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCc3nn[nH]n3)cc2)c1
Show InChI InChI=1S/C26H23FN8O3S/c1-15-4-9-18(27)19(13-15)31-26(37)30-16-5-7-17(8-6-16)38-21-10-12-28-20-14-22(39-24(20)21)25(36)29-11-2-3-23-32-34-35-33-23/h4-10,12-14H,2-3,11H2,1H3,(H,29,36)(H2,30,31,37)(H,32,33,34,35)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228535
PNG
(US9340555, 18)
Show SMILES COC(=O)CNCCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C28H28FN5O5S/c1-17-4-9-20(29)21(14-17)34-28(37)33-18-5-7-19(8-6-18)39-23-10-13-31-22-15-24(40-26(22)23)27(36)32-12-3-11-30-16-25(35)38-2/h4-10,13-15,30H,3,11-12,16H2,1-2H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228573
PNG
(US9340555, 70)
Show SMILES CCN(CC)CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C29H32FN5O3S/c1-4-35(5-2)16-6-14-32-28(36)26-18-24-27(39-26)25(13-15-31-24)38-21-10-8-20(9-11-21)33-29(37)34-23-17-19(3)7-12-22(23)30/h7-13,15,17-18H,4-6,14,16H2,1-3H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228565
PNG
(US9340555, 58)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)N=S(C)(C)=O)cc2F)c1
Show InChI InChI=1S/C24H20F2N4O4S2/c1-13-4-6-15(25)18(10-13)29-24(32)28-17-7-5-14(11-16(17)26)34-20-8-9-27-19-12-21(35-22(19)20)23(31)30-36(2,3)33/h4-12H,1-3H3,(H2,28,29,32)
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US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228572
PNG
(US9340555, 69)
Show SMILES CCN(CC)CCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C28H30FN5O3S/c1-4-34(5-2)15-14-31-27(35)25-17-23-26(38-25)24(12-13-30-23)37-20-9-7-19(8-10-20)32-28(36)33-22-16-18(3)6-11-21(22)29/h6-13,16-17H,4-5,14-15H2,1-3H3,(H,31,35)(H2,32,33,36)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228561
PNG
(US9340555, 54)
Show SMILES COC(=O)CC[C@H](NC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1)C(=O)OC
Show InChI InChI=1S/C29H26F2N4O7S/c1-15-4-6-17(30)21(12-15)35-29(39)34-19-7-5-16(13-18(19)31)42-23-10-11-32-22-14-24(43-26(22)23)27(37)33-20(28(38)41-3)8-9-25(36)40-2/h4-7,10-14,20H,8-9H2,1-3H3,(H,33,37)(H2,34,35,39)/t20-/m0/s1
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228546
PNG
(US9340555, 32)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCN)cc2F)c1
Show InChI InChI=1S/C24H21F2N5O3S/c1-13-2-4-15(25)18(10-13)31-24(33)30-17-5-3-14(11-16(17)26)34-20-6-8-28-19-12-21(35-22(19)20)23(32)29-9-7-27/h2-6,8,10-12H,7,9,27H2,1H3,(H,29,32)(H2,30,31,33)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228531
PNG
(US9340555, 14)
Show SMILES CCOC(=O)CN1CCN(CCCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)cc4)c3s2)CC1
Show InChI InChI=1S/C33H37FN6O5S/c1-3-44-30(41)21-40-17-15-39(16-18-40)14-4-12-36-32(42)29-20-27-31(46-29)28(11-13-35-27)45-24-8-6-23(7-9-24)37-33(43)38-26-19-22(2)5-10-25(26)34/h5-11,13,19-20H,3-4,12,14-18,21H2,1-2H3,(H,36,42)(H2,37,38,43)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228553
PNG
(US9340555, 42)
Show SMILES COC(=O)C1CCCN1CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C31H31F2N5O5S/c1-18-6-8-20(32)23(15-18)37-31(41)36-22-9-7-19(16-21(22)33)43-26-10-12-34-24-17-27(44-28(24)26)29(39)35-11-4-14-38-13-3-5-25(38)30(40)42-2/h6-10,12,15-17,25H,3-5,11,13-14H2,1-2H3,(H,35,39)(H2,36,37,41)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228529
PNG
(US9340555, 12)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCc3nn[nH]n3)cc2)c1
Show InChI InChI=1S/C26H23FN8O3S/c1-15-4-9-18(27)19(13-15)31-26(37)30-16-5-7-17(8-6-16)38-21-10-12-28-20-14-22(39-24(20)21)25(36)29-11-2-3-23-32-34-35-33-23/h4-10,12-14H,2-3,11H2,1H3,(H,29,36)(H2,30,31,37)(H,32,33,34,35)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228534
PNG
(US9340555, 17)
Show SMILES COC(=O)[C@@H]1C[C@@H](O)CN1CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C31H32FN5O6S/c1-18-4-9-22(32)23(14-18)36-31(41)35-19-5-7-21(8-6-19)43-26-10-12-33-24-16-27(44-28(24)26)29(39)34-11-3-13-37-17-20(38)15-25(37)30(40)42-2/h4-10,12,14,16,20,25,38H,3,11,13,15,17H2,1-2H3,(H,34,39)(H2,35,36,41)/t20-,25+/m1/s1
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228569
PNG
(US9340555, 66)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCCCC3)cc2)c1
Show InChI InChI=1S/C30H32FN5O3S/c1-20-6-11-23(31)24(18-20)35-30(38)34-21-7-9-22(10-8-21)39-26-12-14-32-25-19-27(40-28(25)26)29(37)33-13-5-17-36-15-3-2-4-16-36/h6-12,14,18-19H,2-5,13,15-17H2,1H3,(H,33,37)(H2,34,35,38)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228536
PNG
(US9340555, 19)
Show SMILES COC(=O)CN(CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1)CC(=O)OC
Show InChI InChI=1S/C31H32FN5O7S/c1-19-5-10-22(32)23(15-19)36-31(41)35-20-6-8-21(9-7-20)44-25-11-13-33-24-16-26(45-29(24)25)30(40)34-12-4-14-37(17-27(38)42-2)18-28(39)43-3/h5-11,13,15-16H,4,12,14,17-18H2,1-3H3,(H,34,40)(H2,35,36,41)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228542
PNG
(US9340555, 28)
Show SMILES COC(=O)C1CCN(C1)C(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C28H24F2N4O5S/c1-15-3-5-18(29)21(11-15)33-28(37)32-20-6-4-17(12-19(20)30)39-23-7-9-31-22-13-24(40-25(22)23)26(35)34-10-8-16(14-34)27(36)38-2/h3-7,9,11-13,16H,8,10,14H2,1-2H3,(H2,32,33,37)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228531
PNG
(US9340555, 14)
Show SMILES CCOC(=O)CN1CCN(CCCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)cc4)c3s2)CC1
Show InChI InChI=1S/C33H37FN6O5S/c1-3-44-30(41)21-40-17-15-39(16-18-40)14-4-12-36-32(42)29-20-27-31(46-29)28(11-13-35-27)45-24-8-6-23(7-9-24)37-33(43)38-26-19-22(2)5-10-25(26)34/h5-11,13,19-20H,3-4,12,14-18,21H2,1-2H3,(H,36,42)(H2,37,38,43)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228572
PNG
(US9340555, 69)
Show SMILES CCN(CC)CCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C28H30FN5O3S/c1-4-34(5-2)15-14-31-27(35)25-17-23-26(38-25)24(12-13-30-23)37-20-9-7-19(8-10-20)32-28(36)33-22-16-18(3)6-11-21(22)29/h6-13,16-17H,4-5,14-15H2,1-3H3,(H,31,35)(H2,32,33,36)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228552
PNG
(US9340555, 39)
Show SMILES COC(=O)[C@@H]1C[C@@H](O)CN1CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C31H31F2N5O6S/c1-17-4-6-20(32)23(12-17)37-31(42)36-22-7-5-19(14-21(22)33)44-26-8-10-34-24-15-27(45-28(24)26)29(40)35-9-3-11-38-16-18(39)13-25(38)30(41)43-2/h4-8,10,12,14-15,18,25,39H,3,9,11,13,16H2,1-2H3,(H,35,40)(H2,36,37,42)/t18-,25+/m1/s1
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228543
PNG
(US9340555, 29)
Show SMILES CCOC(=O)CN1CCN(CC1)C(=O)CN1CCN(CC1)C(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C36H39F2N7O6S/c1-3-50-33(47)22-43-10-14-44(15-11-43)32(46)21-42-12-16-45(17-13-42)35(48)31-20-29-34(52-31)30(8-9-39-29)51-24-5-7-27(26(38)19-24)40-36(49)41-28-18-23(2)4-6-25(28)37/h4-9,18-20H,3,10-17,21-22H2,1-2H3,(H2,40,41,49)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228539
PNG
(US9340555, 25)
Show SMILES COC(=O)CNCCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C28H27F2N5O5S/c1-16-4-6-18(29)21(12-16)35-28(38)34-20-7-5-17(13-19(20)30)40-23-8-11-32-22-14-24(41-26(22)23)27(37)33-10-3-9-31-15-25(36)39-2/h4-8,11-14,31H,3,9-10,15H2,1-2H3,(H,33,37)(H2,34,35,38)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228540
PNG
(US9340555, 26)
Show SMILES COC(=O)CN(CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1)CC(=O)OC
Show InChI InChI=1S/C31H31F2N5O7S/c1-18-5-7-20(32)23(13-18)37-31(42)36-22-8-6-19(14-21(22)33)45-25-9-11-34-24-15-26(46-29(24)25)30(41)35-10-4-12-38(16-27(39)43-2)17-28(40)44-3/h5-9,11,13-15H,4,10,12,16-17H2,1-3H3,(H,35,41)(H2,36,37,42)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228554
PNG
(US9340555, 43)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCCC3)cc2F)c1
Show InChI InChI=1S/C29H29F2N5O3S/c1-18-5-7-20(30)23(15-18)35-29(38)34-22-8-6-19(16-21(22)31)39-25-9-11-32-24-17-26(40-27(24)25)28(37)33-10-4-14-36-12-2-3-13-36/h5-9,11,15-17H,2-4,10,12-14H2,1H3,(H,33,37)(H2,34,35,38)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228548
PNG
(US9340555, 34)
Show SMILES CN1CCN(CCCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)c(F)c4)c3s2)CC1
Show InChI InChI=1S/C30H32F2N6O3S/c1-19-4-6-21(31)24(16-19)36-30(40)35-23-7-5-20(17-22(23)32)41-26-8-10-33-25-18-27(42-28(25)26)29(39)34-9-3-11-38-14-12-37(2)13-15-38/h4-8,10,16-18H,3,9,11-15H2,1-2H3,(H,34,39)(H2,35,36,40)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228571
PNG
(US9340555, 68)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCCC3)cc2)c1
Show InChI InChI=1S/C29H30FN5O3S/c1-19-5-10-22(30)23(17-19)34-29(37)33-20-6-8-21(9-7-20)38-25-11-13-31-24-18-26(39-27(24)25)28(36)32-12-4-16-35-14-2-3-15-35/h5-11,13,17-18H,2-4,12,14-16H2,1H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228530
PNG
(US9340555, 13)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCc3nn[nH]n3)cc2)c1
Show InChI InChI=1S/C25H21FN8O3S/c1-14-2-7-17(26)18(12-14)30-25(36)29-15-3-5-16(6-4-15)37-20-8-10-27-19-13-21(38-23(19)20)24(35)28-11-9-22-31-33-34-32-22/h2-8,10,12-13H,9,11H2,1H3,(H,28,35)(H2,29,30,36)(H,31,32,33,34)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228535
PNG
(US9340555, 18)
Show SMILES COC(=O)CNCCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C28H28FN5O5S/c1-17-4-9-20(29)21(14-17)34-28(37)33-18-5-7-19(8-6-18)39-23-10-13-31-22-15-24(40-26(22)23)27(36)32-12-3-11-30-16-25(35)38-2/h4-10,13-15,30H,3,11-12,16H2,1-2H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228553
PNG
(US9340555, 42)
Show SMILES COC(=O)C1CCCN1CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C31H31F2N5O5S/c1-18-6-8-20(32)23(15-18)37-31(41)36-22-9-7-19(16-21(22)33)43-26-10-12-34-24-17-27(44-28(24)26)29(39)35-11-4-14-38-13-3-5-25(38)30(40)42-2/h6-10,12,15-17,25H,3-5,11,13-14H2,1-2H3,(H,35,39)(H2,36,37,41)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228533
PNG
(US9340555, 16)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCOC(CO)C3)cc2)c1
Show InChI InChI=1S/C30H32FN5O5S/c1-19-3-8-23(31)24(15-19)35-30(39)34-20-4-6-21(7-5-20)41-26-9-11-32-25-16-27(42-28(25)26)29(38)33-10-2-12-36-13-14-40-22(17-36)18-37/h3-9,11,15-16,22,37H,2,10,12-14,17-18H2,1H3,(H,33,38)(H2,34,35,39)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228549
PNG
(US9340555, 36)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCCC(CO)C3)cc2F)c1
Show InChI InChI=1S/C31H33F2N5O4S/c1-19-5-7-22(32)25(14-19)37-31(41)36-24-8-6-21(15-23(24)33)42-27-9-11-34-26-16-28(43-29(26)27)30(40)35-10-3-13-38-12-2-4-20(17-38)18-39/h5-9,11,14-16,20,39H,2-4,10,12-13,17-18H2,1H3,(H,35,40)(H2,36,37,41)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228550
PNG
(US9340555, 37)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCOC(CO)C3)cc2F)c1
Show InChI InChI=1S/C30H31F2N5O5S/c1-18-3-5-21(31)24(13-18)36-30(40)35-23-6-4-19(14-22(23)32)42-26-7-9-33-25-15-27(43-28(25)26)29(39)34-8-2-10-37-11-12-41-20(16-37)17-38/h3-7,9,13-15,20,38H,2,8,10-12,16-17H2,1H3,(H,34,39)(H2,35,36,40)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228556
PNG
(US9340555, 45)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN)cc2F)c1
Show InChI InChI=1S/C25H23F2N5O3S/c1-14-3-5-16(26)19(11-14)32-25(34)31-18-6-4-15(12-17(18)27)35-21-7-10-29-20-13-22(36-23(20)21)24(33)30-9-2-8-28/h3-7,10-13H,2,8-9,28H2,1H3,(H,30,33)(H2,31,32,34)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228537
PNG
(US9340555, 23)
Show SMILES CCOC(=O)N1CCN(CCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)c(F)c4)c3s2)CC1
Show InChI InChI=1S/C31H32F2N6O5S/c1-3-43-31(42)39-14-12-38(13-15-39)11-10-35-29(40)27-18-25-28(45-27)26(8-9-34-25)44-20-5-7-23(22(33)17-20)36-30(41)37-24-16-19(2)4-6-21(24)32/h4-9,16-18H,3,10-15H2,1-2H3,(H,35,40)(H2,36,37,41)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228567
PNG
(US9340555, 64)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCC(O)=O)cc2F)c1
Show InChI InChI=1S/C26H22F2N4O5S/c1-14-4-6-16(27)19(11-14)32-26(36)31-18-7-5-15(12-17(18)28)37-21-8-10-29-20-13-22(38-24(20)21)25(35)30-9-2-3-23(33)34/h4-8,10-13H,2-3,9H2,1H3,(H,30,35)(H,33,34)(H2,31,32,36)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228568
PNG
(US9340555, 65)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCC(O)=O)cc2)c1
Show InChI InChI=1S/C26H23FN4O5S/c1-15-4-9-18(27)19(13-15)31-26(35)30-16-5-7-17(8-6-16)36-21-10-12-28-20-14-22(37-24(20)21)25(34)29-11-2-3-23(32)33/h4-10,12-14H,2-3,11H2,1H3,(H,29,34)(H,32,33)(H2,30,31,35)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228562
PNG
(US9340555, 55)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCOCC3)cc2F)c1
Show InChI InChI=1S/C29H29F2N5O4S/c1-18-3-5-20(30)23(15-18)35-29(38)34-22-6-4-19(16-21(22)31)40-25-7-9-32-24-17-26(41-27(24)25)28(37)33-8-2-10-36-11-13-39-14-12-36/h3-7,9,15-17H,2,8,10-14H2,1H3,(H,33,37)(H2,34,35,38)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228562
PNG
(US9340555, 55)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCOCC3)cc2F)c1
Show InChI InChI=1S/C29H29F2N5O4S/c1-18-3-5-20(30)23(15-18)35-29(38)34-22-6-4-19(16-21(22)31)40-25-7-9-32-24-17-26(41-27(24)25)28(37)33-8-2-10-36-11-13-39-14-12-36/h3-7,9,15-17H,2,8,10-14H2,1H3,(H,33,37)(H2,34,35,38)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228551
PNG
(US9340555, 38)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCC(O)CC3)cc2F)c1
Show InChI InChI=1S/C30H31F2N5O4S/c1-18-3-5-21(31)24(15-18)36-30(40)35-23-6-4-20(16-22(23)32)41-26-7-11-33-25-17-27(42-28(25)26)29(39)34-10-2-12-37-13-8-19(38)9-14-37/h3-7,11,15-17,19,38H,2,8-10,12-14H2,1H3,(H,34,39)(H2,35,36,40)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228558
PNG
(US9340555, 48)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(O)=O)cc2F)c1
Show InChI InChI=1S/C31H30F2N4O7S/c1-16-5-7-18(32)22(13-16)37-30(42)36-20-8-6-17(14-19(20)33)43-24-11-12-34-23-15-25(45-27(23)24)28(39)35-21(29(40)41)9-10-26(38)44-31(2,3)4/h5-8,11-15,21H,9-10H2,1-4H3,(H,35,39)(H,40,41)(H2,36,37,42)/t21-/m0/s1
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228588
PNG
(US9340555, 86)
Show SMILES CCN(CC)C(=O)c1cc2nccc(Oc3cccc(c3)C(=O)Nc3cc(C)ccc3F)c2s1
Show InChI InChI=1S/C26H24FN3O3S/c1-4-30(5-2)26(32)23-15-21-24(34-23)22(11-12-28-21)33-18-8-6-7-17(14-18)25(31)29-20-13-16(3)9-10-19(20)27/h6-15H,4-5H2,1-3H3,(H,29,31)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228544
PNG
(US9340555, 30)
Show SMILES CCOC(=O)CN1CCN(CC1)C(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C30H29F2N5O5S/c1-3-41-27(38)17-36-10-12-37(13-11-36)29(39)26-16-24-28(43-26)25(8-9-33-24)42-19-5-7-22(21(32)15-19)34-30(40)35-23-14-18(2)4-6-20(23)31/h4-9,14-16H,3,10-13,17H2,1-2H3,(H2,34,35,40)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228552
PNG
(US9340555, 39)
Show SMILES COC(=O)[C@@H]1C[C@@H](O)CN1CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C31H31F2N5O6S/c1-17-4-6-20(32)23(12-17)37-31(42)36-22-7-5-19(14-21(22)33)44-26-8-10-34-24-15-27(45-28(24)26)29(40)35-9-3-11-38-16-18(39)13-25(38)30(41)43-2/h4-8,10,12,14-15,18,25,39H,3,9,11,13,16H2,1-2H3,(H,35,40)(H2,36,37,42)/t18-,25+/m1/s1
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228539
PNG
(US9340555, 25)
Show SMILES COC(=O)CNCCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C28H27F2N5O5S/c1-16-4-6-18(29)21(12-16)35-28(38)34-20-7-5-17(13-19(20)30)40-23-8-11-32-22-14-24(41-26(22)23)27(37)33-10-3-9-31-15-25(36)39-2/h4-8,11-14,31H,3,9-10,15H2,1-2H3,(H,33,37)(H2,34,35,38)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228542
PNG
(US9340555, 28)
Show SMILES COC(=O)C1CCN(C1)C(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C28H24F2N4O5S/c1-15-3-5-18(29)21(11-15)33-28(37)32-20-6-4-17(12-19(20)30)39-23-7-9-31-22-13-24(40-25(22)23)26(35)34-10-8-16(14-34)27(36)38-2/h3-7,9,11-13,16H,8,10,14H2,1-2H3,(H2,32,33,37)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228549
PNG
(US9340555, 36)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCCC(CO)C3)cc2F)c1
Show InChI InChI=1S/C31H33F2N5O4S/c1-19-5-7-22(32)25(14-19)37-31(41)36-24-8-6-21(15-23(24)33)42-27-9-11-34-26-16-28(43-29(26)27)30(40)35-10-3-13-38-12-2-4-20(17-38)18-39/h5-9,11,14-16,20,39H,2-4,10,12-13,17-18H2,1H3,(H,35,40)(H2,36,37,41)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228551
PNG
(US9340555, 38)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCC(O)CC3)cc2F)c1
Show InChI InChI=1S/C30H31F2N5O4S/c1-18-3-5-21(31)24(15-18)36-30(40)35-23-6-4-20(16-22(23)32)41-26-7-11-33-25-17-27(42-28(25)26)29(39)34-10-2-12-37-13-8-19(38)9-14-37/h3-7,11,15-17,19,38H,2,8-10,12-14H2,1H3,(H,34,39)(H2,35,36,40)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228545
PNG
(US9340555, 31)
Show SMILES COC(=O)CNCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C27H25F2N5O5S/c1-15-3-5-17(28)20(11-15)34-27(37)33-19-6-4-16(12-18(19)29)39-22-7-8-31-21-13-23(40-25(21)22)26(36)32-10-9-30-14-24(35)38-2/h3-8,11-13,30H,9-10,14H2,1-2H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228536
PNG
(US9340555, 19)
Show SMILES COC(=O)CN(CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1)CC(=O)OC
Show InChI InChI=1S/C31H32FN5O7S/c1-19-5-10-22(32)23(15-19)36-31(41)35-20-6-8-21(9-7-20)44-25-11-13-33-24-16-26(45-29(24)25)30(40)34-12-4-14-37(17-27(38)42-2)18-28(39)43-3/h5-11,13,15-16H,4,12,14,17-18H2,1-3H3,(H,34,40)(H2,35,36,41)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228538
PNG
(US9340555, 24)
Show SMILES CCOC(=O)N1CCN(CCCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)c(F)c4)c3s2)CC1
Show InChI InChI=1S/C32H34F2N6O5S/c1-3-44-32(43)40-15-13-39(14-16-40)12-4-10-36-30(41)28-19-26-29(46-28)27(9-11-35-26)45-21-6-8-24(23(34)18-21)37-31(42)38-25-17-20(2)5-7-22(25)33/h5-9,11,17-19H,3-4,10,12-16H2,1-2H3,(H,36,41)(H2,37,38,42)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228576
PNG
(US9340555, 73)
Show SMILES CCNC(=O)c1cc2nccc(Oc3cccc(NC(=O)c4occc4C)c3)c2s1
Show InChI InChI=1S/C22H19N3O4S/c1-3-23-21(26)18-12-16-20(30-18)17(7-9-24-16)29-15-6-4-5-14(11-15)25-22(27)19-13(2)8-10-28-19/h4-12H,3H2,1-2H3,(H,23,26)(H,25,27)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228573
PNG
(US9340555, 70)
Show SMILES CCN(CC)CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C29H32FN5O3S/c1-4-35(5-2)16-6-14-32-28(36)26-18-24-27(39-26)25(13-15-31-24)38-21-10-8-20(9-11-21)33-29(37)34-23-17-19(3)7-12-22(23)30/h7-13,15,17-18H,4-6,14,16H2,1-3H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228589
PNG
(US9340555, 87)
Show SMILES COC(=O)CNCCCNC(=O)c1cc2nccc(Oc3cccc(c3)C(=O)Nc3cc(C)ccc3F)c2s1
Show InChI InChI=1S/C28H27FN4O5S/c1-17-7-8-20(29)21(13-17)33-27(35)18-5-3-6-19(14-18)38-23-9-12-31-22-15-24(39-26(22)23)28(36)32-11-4-10-30-16-25(34)37-2/h3,5-9,12-15,30H,4,10-11,16H2,1-2H3,(H,32,36)(H,33,35)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228545
PNG
(US9340555, 31)
Show SMILES COC(=O)CNCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C27H25F2N5O5S/c1-15-3-5-17(28)20(11-15)34-27(37)33-19-6-4-16(12-18(19)29)39-22-7-8-31-21-13-23(40-25(21)22)26(36)32-10-9-30-14-24(35)38-2/h3-8,11-13,30H,9-10,14H2,1-2H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228570
PNG
(US9340555, 67)
Show SMILES CN1CCN(CCCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)cc4)c3s2)CC1
Show InChI InChI=1S/C30H33FN6O3S/c1-20-4-9-23(31)24(18-20)35-30(39)34-21-5-7-22(8-6-21)40-26-10-12-32-25-19-27(41-28(25)26)29(38)33-11-3-13-37-16-14-36(2)15-17-37/h4-10,12,18-19H,3,11,13-17H2,1-2H3,(H,33,38)(H2,34,35,39)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228550
PNG
(US9340555, 37)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCOC(CO)C3)cc2F)c1
Show InChI InChI=1S/C30H31F2N5O5S/c1-18-3-5-21(31)24(13-18)36-30(40)35-23-6-4-19(14-22(23)32)42-26-7-9-33-25-15-27(43-28(25)26)29(39)34-8-2-10-37-11-12-41-20(16-37)17-38/h3-7,9,13-15,20,38H,2,8,10-12,16-17H2,1H3,(H,34,39)(H2,35,36,40)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228537
PNG
(US9340555, 23)
Show SMILES CCOC(=O)N1CCN(CCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)c(F)c4)c3s2)CC1
Show InChI InChI=1S/C31H32F2N6O5S/c1-3-43-31(42)39-14-12-38(13-15-39)11-10-35-29(40)27-18-25-28(45-27)26(8-9-34-25)44-20-5-7-23(22(33)17-20)36-30(41)37-24-16-19(2)4-6-21(24)32/h4-9,16-18H,3,10-15H2,1-2H3,(H,35,40)(H2,36,37,41)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228582
PNG
(US9340555, 79)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(=O)OCCCO)c1
Show InChI InChI=1S/C23H20N2O6S/c1-14-7-11-29-20(14)22(27)25-15-4-2-5-16(12-15)31-18-6-8-24-17-13-19(32-21(17)18)23(28)30-10-3-9-26/h2,4-8,11-13,26H,3,9-10H2,1H3,(H,25,27)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228540
PNG
(US9340555, 26)
Show SMILES COC(=O)CN(CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1)CC(=O)OC
Show InChI InChI=1S/C31H31F2N5O7S/c1-18-5-7-20(32)23(13-18)37-31(42)36-22-8-6-19(14-21(22)33)45-25-9-11-34-24-15-26(46-29(24)25)30(41)35-10-4-12-38(16-27(39)43-2)17-28(40)44-3/h5-9,11,13-15H,4,10,12,16-17H2,1-3H3,(H,35,41)(H2,36,37,42)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228534
PNG
(US9340555, 17)
Show SMILES COC(=O)[C@@H]1C[C@@H](O)CN1CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C31H32FN5O6S/c1-18-4-9-22(32)23(14-18)36-31(41)35-19-5-7-21(8-6-19)43-26-10-12-33-24-16-27(44-28(24)26)29(39)34-11-3-13-37-17-20(38)15-25(37)30(40)42-2/h4-10,12,14,16,20,25,38H,3,11,13,15,17H2,1-2H3,(H,34,39)(H2,35,36,41)/t20-,25+/m1/s1
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228527
PNG
(US9340555, F7)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCC(O)=O)cc2F)c1
Show InChI InChI=1S/C25H20F2N4O5S/c1-13-2-4-15(26)18(10-13)31-25(35)30-17-5-3-14(11-16(17)27)36-20-6-8-28-19-12-21(37-23(19)20)24(34)29-9-7-22(32)33/h2-6,8,10-12H,7,9H2,1H3,(H,29,34)(H,32,33)(H2,30,31,35)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228533
PNG
(US9340555, 16)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCOC(CO)C3)cc2)c1
Show InChI InChI=1S/C30H32FN5O5S/c1-19-3-8-23(31)24(15-19)35-30(39)34-20-4-6-21(7-5-20)41-26-9-11-32-25-16-27(42-28(25)26)29(38)33-10-2-12-36-13-14-40-22(17-36)18-37/h3-9,11,15-16,22,37H,2,10,12-14,17-18H2,1H3,(H,33,38)(H2,34,35,39)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228543
PNG
(US9340555, 29)
Show SMILES CCOC(=O)CN1CCN(CC1)C(=O)CN1CCN(CC1)C(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C36H39F2N7O6S/c1-3-50-33(47)22-43-10-14-44(15-11-43)32(46)21-42-12-16-45(17-13-42)35(48)31-20-29-34(52-31)30(8-9-39-29)51-24-5-7-27(26(38)19-24)40-36(49)41-28-18-23(2)4-6-25(28)37/h4-9,18-20H,3,10-17,21-22H2,1-2H3,(H2,40,41,49)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228532
PNG
(US9340555, 15)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCCC(CO)C3)cc2)c1
Show InChI InChI=1S/C31H34FN5O4S/c1-20-5-10-24(32)25(16-20)36-31(40)35-22-6-8-23(9-7-22)41-27-11-13-33-26-17-28(42-29(26)27)30(39)34-12-3-15-37-14-2-4-21(18-37)19-38/h5-11,13,16-17,21,38H,2-4,12,14-15,18-19H2,1H3,(H,34,39)(H2,35,36,40)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228587
PNG
(US9340555, 85)
Show SMILES CCNC(=O)c1cc2nccc(Oc3cccc(c3)C(=O)Nc3cc(C)ccc3F)c2s1
Show InChI InChI=1S/C24H20FN3O3S/c1-3-26-24(30)21-13-19-22(32-21)20(9-10-27-19)31-16-6-4-5-15(12-16)23(29)28-18-11-14(2)7-8-17(18)25/h4-13H,3H2,1-2H3,(H,26,30)(H,28,29)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228556
PNG
(US9340555, 45)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN)cc2F)c1
Show InChI InChI=1S/C25H23F2N5O3S/c1-14-3-5-16(26)19(11-14)32-25(34)31-18-6-4-15(12-17(18)27)35-21-7-10-29-20-13-22(36-23(20)21)24(33)30-9-2-8-28/h3-7,10-13H,2,8-9,28H2,1H3,(H,30,33)(H2,31,32,34)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228538
PNG
(US9340555, 24)
Show SMILES CCOC(=O)N1CCN(CCCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)c(F)c4)c3s2)CC1
Show InChI InChI=1S/C32H34F2N6O5S/c1-3-44-32(43)40-15-13-39(14-16-40)12-4-10-36-30(41)28-19-26-29(46-28)27(9-11-35-26)45-21-6-8-24(23(34)18-21)37-31(42)38-25-17-20(2)5-7-22(25)33/h5-9,11,17-19H,3-4,10,12-16H2,1-2H3,(H,36,41)(H2,37,38,42)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228530
PNG
(US9340555, 13)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCc3nn[nH]n3)cc2)c1
Show InChI InChI=1S/C25H21FN8O3S/c1-14-2-7-17(26)18(12-14)30-25(36)29-15-3-5-16(6-4-15)37-20-8-10-27-19-13-21(38-23(19)20)24(35)28-11-9-22-31-33-34-32-22/h2-8,10,12-13H,9,11H2,1H3,(H,28,35)(H2,29,30,36)(H,31,32,33,34)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228555
PNG
(US9340555, 44)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCNC(=O)OC(C)(C)C)cc2F)c1
Show InChI InChI=1S/C30H31F2N5O5S/c1-17-6-8-19(31)22(14-17)37-28(39)36-21-9-7-18(15-20(21)32)41-24-10-13-33-23-16-25(43-26(23)24)27(38)34-11-5-12-35-29(40)42-30(2,3)4/h6-10,13-16H,5,11-12H2,1-4H3,(H,34,38)(H,35,40)(H2,36,37,39)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228585
PNG
(US9340555, 82)
Show SMILES COC(=O)CNCCCNC(=O)c1cc2nccc(Oc3cccc(NC(=O)c4occc4C)c3)c2s1
Show InChI InChI=1S/C26H26N4O6S/c1-16-8-12-35-23(16)26(33)30-17-5-3-6-18(13-17)36-20-7-11-28-19-14-21(37-24(19)20)25(32)29-10-4-9-27-15-22(31)34-2/h3,5-8,11-14,27H,4,9-10,15H2,1-2H3,(H,29,32)(H,30,33)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228546
PNG
(US9340555, 32)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCN)cc2F)c1
Show InChI InChI=1S/C24H21F2N5O3S/c1-13-2-4-15(25)18(10-13)31-24(33)30-17-5-3-14(11-16(17)26)34-20-6-8-28-19-12-21(35-22(19)20)23(32)29-9-7-27/h2-6,8,10-12H,7,9,27H2,1H3,(H,29,32)(H2,30,31,33)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228541
PNG
(US9340555, 27)
Show SMILES COC(=O)CN(CCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1)CC(=O)OC
Show InChI InChI=1S/C30H29F2N5O7S/c1-17-4-6-19(31)22(12-17)36-30(41)35-21-7-5-18(13-20(21)32)44-24-8-9-33-23-14-25(45-28(23)24)29(40)34-10-11-37(15-26(38)42-2)16-27(39)43-3/h4-9,12-14H,10-11,15-16H2,1-3H3,(H,34,40)(H2,35,36,41)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228535
PNG
(US9340555, 18)
Show SMILES COC(=O)CNCCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C28H28FN5O5S/c1-17-4-9-20(29)21(14-17)34-28(37)33-18-5-7-19(8-6-18)39-23-10-13-31-22-15-24(40-26(22)23)27(36)32-12-3-11-30-16-25(35)38-2/h4-10,13-15,30H,3,11-12,16H2,1-2H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228562
PNG
(US9340555, 55)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCOCC3)cc2F)c1
Show InChI InChI=1S/C29H29F2N5O4S/c1-18-3-5-20(30)23(15-18)35-29(38)34-22-6-4-19(16-21(22)31)40-25-7-9-32-24-17-26(41-27(24)25)28(37)33-8-2-10-36-11-13-39-14-12-36/h3-7,9,15-17H,2,8,10-14H2,1H3,(H,33,37)(H2,34,35,38)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228528
PNG
(US9340555, F8)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(O)=O)cc2F)c1
Show InChI InChI=1S/C22H15F2N3O4S/c1-11-2-4-13(23)16(8-11)27-22(30)26-15-5-3-12(9-14(15)24)31-18-6-7-25-17-10-19(21(28)29)32-20(17)18/h2-10H,1H3,(H,28,29)(H2,26,27,30)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228578
PNG
(US9340555, 75)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(=O)NO)c1
Show InChI InChI=1S/C20H15N3O5S/c1-11-6-8-27-17(11)20(25)22-12-3-2-4-13(9-12)28-15-5-7-21-14-10-16(19(24)23-26)29-18(14)15/h2-10,26H,1H3,(H,22,25)(H,23,24)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228526
PNG
(US9340555, F6)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCC(O)=O)cc2)c1
Show InChI InChI=1S/C25H21FN4O5S/c1-14-2-7-17(26)18(12-14)30-25(34)29-15-3-5-16(6-4-15)35-20-8-10-27-19-13-21(36-23(19)20)24(33)28-11-9-22(31)32/h2-8,10,12-13H,9,11H2,1H3,(H,28,33)(H,31,32)(H2,29,30,34)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228572
PNG
(US9340555, 69)
Show SMILES CCN(CC)CCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C28H30FN5O3S/c1-4-34(5-2)15-14-31-27(35)25-17-23-26(38-25)24(12-13-30-23)37-20-9-7-19(8-10-20)32-28(36)33-22-16-18(3)6-11-21(22)29/h6-13,16-17H,4-5,14-15H2,1-3H3,(H,31,35)(H2,32,33,36)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228579
PNG
(US9340555, 76)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(=O)NCCCO)c1
Show InChI InChI=1S/C23H21N3O5S/c1-14-7-11-30-20(14)23(29)26-15-4-2-5-16(12-15)31-18-6-9-24-17-13-19(32-21(17)18)22(28)25-8-3-10-27/h2,4-7,9,11-13,27H,3,8,10H2,1H3,(H,25,28)(H,26,29)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228539
PNG
(US9340555, 25)
Show SMILES COC(=O)CNCCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C28H27F2N5O5S/c1-16-4-6-18(29)21(12-16)35-28(38)34-20-7-5-17(13-19(20)30)40-23-8-11-32-22-14-24(41-26(22)23)27(37)33-10-3-9-31-15-25(36)39-2/h4-8,11-14,31H,3,9-10,15H2,1-2H3,(H,33,37)(H2,34,35,38)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228548
PNG
(US9340555, 34)
Show SMILES CN1CCN(CCCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)c(F)c4)c3s2)CC1
Show InChI InChI=1S/C30H32F2N6O3S/c1-19-4-6-21(31)24(16-19)36-30(40)35-23-7-5-20(17-22(23)32)41-26-8-10-33-25-18-27(42-28(25)26)29(39)34-9-3-11-38-14-12-37(2)13-15-38/h4-8,10,16-18H,3,9,11-15H2,1-2H3,(H,34,39)(H2,35,36,40)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228573
PNG
(US9340555, 70)
Show SMILES CCN(CC)CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C29H32FN5O3S/c1-4-35(5-2)16-6-14-32-28(36)26-18-24-27(39-26)25(13-15-31-24)38-21-10-8-20(9-11-21)33-29(37)34-23-17-19(3)7-12-22(23)30/h7-13,15,17-18H,4-6,14,16H2,1-3H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228540
PNG
(US9340555, 26)
Show SMILES COC(=O)CN(CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1)CC(=O)OC
Show InChI InChI=1S/C31H31F2N5O7S/c1-18-5-7-20(32)23(13-18)37-31(42)36-22-8-6-19(14-21(22)33)45-25-9-11-34-24-15-26(46-29(24)25)30(41)35-10-4-12-38(16-27(39)43-2)17-28(40)44-3/h5-9,11,13-15H,4,10,12,16-17H2,1-3H3,(H,35,41)(H2,36,37,42)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228568
PNG
(US9340555, 65)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCC(O)=O)cc2)c1
Show InChI InChI=1S/C26H23FN4O5S/c1-15-4-9-18(27)19(13-15)31-26(35)30-16-5-7-17(8-6-16)36-21-10-12-28-20-14-22(37-24(20)21)25(34)29-11-2-3-23(32)33/h4-10,12-14H,2-3,11H2,1H3,(H,29,34)(H,32,33)(H2,30,31,35)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228560
PNG
(US9340555, 53)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCO)cc2F)c1
Show InChI InChI=1S/C25H22F2N4O4S/c1-14-3-5-16(26)19(11-14)31-25(34)30-18-6-4-15(12-17(18)27)35-21-7-9-28-20-13-22(36-23(20)21)24(33)29-8-2-10-32/h3-7,9,11-13,32H,2,8,10H2,1H3,(H,29,33)(H2,30,31,34)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228572
PNG
(US9340555, 69)
Show SMILES CCN(CC)CCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C28H30FN5O3S/c1-4-34(5-2)15-14-31-27(35)25-17-23-26(38-25)24(12-13-30-23)37-20-9-7-19(8-10-20)32-28(36)33-22-16-18(3)6-11-21(22)29/h6-13,16-17H,4-5,14-15H2,1-3H3,(H,31,35)(H2,32,33,36)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228567
PNG
(US9340555, 64)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCC(O)=O)cc2F)c1
Show InChI InChI=1S/C26H22F2N4O5S/c1-14-4-6-16(27)19(11-14)32-26(36)31-18-7-5-15(12-17(18)28)37-21-8-10-29-20-13-22(38-24(20)21)25(35)30-9-2-3-23(33)34/h4-8,10-13H,2-3,9H2,1H3,(H,30,35)(H,33,34)(H2,31,32,36)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228537
PNG
(US9340555, 23)
Show SMILES CCOC(=O)N1CCN(CCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)c(F)c4)c3s2)CC1
Show InChI InChI=1S/C31H32F2N6O5S/c1-3-43-31(42)39-14-12-38(13-15-39)11-10-35-29(40)27-18-25-28(45-27)26(8-9-34-25)44-20-5-7-23(22(33)17-20)36-30(41)37-24-16-19(2)4-6-21(24)32/h4-9,16-18H,3,10-15H2,1-2H3,(H,35,40)(H2,36,37,41)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228543
PNG
(US9340555, 29)
Show SMILES CCOC(=O)CN1CCN(CC1)C(=O)CN1CCN(CC1)C(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C36H39F2N7O6S/c1-3-50-33(47)22-43-10-14-44(15-11-43)32(46)21-42-12-16-45(17-13-42)35(48)31-20-29-34(52-31)30(8-9-39-29)51-24-5-7-27(26(38)19-24)40-36(49)41-28-18-23(2)4-6-25(28)37/h4-9,18-20H,3,10-17,21-22H2,1-2H3,(H2,40,41,49)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228531
PNG
(US9340555, 14)
Show SMILES CCOC(=O)CN1CCN(CCCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)cc4)c3s2)CC1
Show InChI InChI=1S/C33H37FN6O5S/c1-3-44-30(41)21-40-17-15-39(16-18-40)14-4-12-36-32(42)29-20-27-31(46-29)28(11-13-35-27)45-24-8-6-23(7-9-24)37-33(43)38-26-19-22(2)5-10-25(26)34/h5-11,13,19-20H,3-4,12,14-18,21H2,1-2H3,(H,36,42)(H2,37,38,43)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228545
PNG
(US9340555, 31)
Show SMILES COC(=O)CNCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C27H25F2N5O5S/c1-15-3-5-17(28)20(11-15)34-27(37)33-19-6-4-16(12-18(19)29)39-22-7-8-31-21-13-23(40-25(21)22)26(36)32-10-9-30-14-24(35)38-2/h3-8,11-13,30H,9-10,14H2,1-2H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228564
PNG
(US9340555, 57)
Show SMILES CCOC(=O)CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C28H26F2N4O5S/c1-3-38-25(35)5-4-11-32-27(36)24-15-22-26(40-24)23(10-12-31-22)39-17-7-9-20(19(30)14-17)33-28(37)34-21-13-16(2)6-8-18(21)29/h6-10,12-15H,3-5,11H2,1-2H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228551
PNG
(US9340555, 38)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCC(O)CC3)cc2F)c1
Show InChI InChI=1S/C30H31F2N5O4S/c1-18-3-5-21(31)24(15-18)36-30(40)35-23-6-4-20(16-22(23)32)41-26-7-11-33-25-17-27(42-28(25)26)29(39)34-10-2-12-37-13-8-19(38)9-14-37/h3-7,11,15-17,19,38H,2,8-10,12-14H2,1H3,(H,34,39)(H2,35,36,40)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228537
PNG
(US9340555, 23)
Show SMILES CCOC(=O)N1CCN(CCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)c(F)c4)c3s2)CC1
Show InChI InChI=1S/C31H32F2N6O5S/c1-3-43-31(42)39-14-12-38(13-15-39)11-10-35-29(40)27-18-25-28(45-27)26(8-9-34-25)44-20-5-7-23(22(33)17-20)36-30(41)37-24-16-19(2)4-6-21(24)32/h4-9,16-18H,3,10-15H2,1-2H3,(H,35,40)(H2,36,37,41)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228536
PNG
(US9340555, 19)
Show SMILES COC(=O)CN(CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1)CC(=O)OC
Show InChI InChI=1S/C31H32FN5O7S/c1-19-5-10-22(32)23(15-19)36-31(41)35-20-6-8-21(9-7-20)44-25-11-13-33-24-16-26(45-29(24)25)30(40)34-12-4-14-37(17-27(38)42-2)18-28(39)43-3/h5-11,13,15-16H,4,12,14,17-18H2,1-3H3,(H,34,40)(H2,35,36,41)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228538
PNG
(US9340555, 24)
Show SMILES CCOC(=O)N1CCN(CCCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)c(F)c4)c3s2)CC1
Show InChI InChI=1S/C32H34F2N6O5S/c1-3-44-32(43)40-15-13-39(14-16-40)12-4-10-36-30(41)28-19-26-29(46-28)27(9-11-35-26)45-21-6-8-24(23(34)18-21)37-31(42)38-25-17-20(2)5-7-22(25)33/h5-9,11,17-19H,3-4,10,12-16H2,1-2H3,(H,36,41)(H2,37,38,42)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228581
PNG
(US9340555, 78)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(=O)NCCc2nn[nH]n2)c1
Show InChI InChI=1S/C23H19N7O4S/c1-13-7-10-33-20(13)23(32)26-14-3-2-4-15(11-14)34-17-5-8-24-16-12-18(35-21(16)17)22(31)25-9-6-19-27-29-30-28-19/h2-5,7-8,10-12H,6,9H2,1H3,(H,25,31)(H,26,32)(H,27,28,29,30)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228538
PNG
(US9340555, 24)
Show SMILES CCOC(=O)N1CCN(CCCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)c(F)c4)c3s2)CC1
Show InChI InChI=1S/C32H34F2N6O5S/c1-3-44-32(43)40-15-13-39(14-16-40)12-4-10-36-30(41)28-19-26-29(46-28)27(9-11-35-26)45-21-6-8-24(23(34)18-21)37-31(42)38-25-17-20(2)5-7-22(25)33/h5-9,11,17-19H,3-4,10,12-16H2,1-2H3,(H,36,41)(H2,37,38,42)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228564
PNG
(US9340555, 57)
Show SMILES CCOC(=O)CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C28H26F2N4O5S/c1-3-38-25(35)5-4-11-32-27(36)24-15-22-26(40-24)23(10-12-31-22)39-17-7-9-20(19(30)14-17)33-28(37)34-21-13-16(2)6-8-18(21)29/h6-10,12-15H,3-5,11H2,1-2H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228533
PNG
(US9340555, 16)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCOC(CO)C3)cc2)c1
Show InChI InChI=1S/C30H32FN5O5S/c1-19-3-8-23(31)24(15-19)35-30(39)34-20-4-6-21(7-5-20)41-26-9-11-32-25-16-27(42-28(25)26)29(38)33-10-2-12-36-13-14-40-22(17-36)18-37/h3-9,11,15-16,22,37H,2,10,12-14,17-18H2,1H3,(H,33,38)(H2,34,35,39)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228534
PNG
(US9340555, 17)
Show SMILES COC(=O)[C@@H]1C[C@@H](O)CN1CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C31H32FN5O6S/c1-18-4-9-22(32)23(14-18)36-31(41)35-19-5-7-21(8-6-19)43-26-10-12-33-24-16-27(44-28(24)26)29(39)34-11-3-13-37-17-20(38)15-25(37)30(40)42-2/h4-10,12,14,16,20,25,38H,3,11,13,15,17H2,1-2H3,(H,34,39)(H2,35,36,41)/t20-,25+/m1/s1
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228546
PNG
(US9340555, 32)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCN)cc2F)c1
Show InChI InChI=1S/C24H21F2N5O3S/c1-13-2-4-15(25)18(10-13)31-24(33)30-17-5-3-14(11-16(17)26)34-20-6-8-28-19-12-21(35-22(19)20)23(32)29-9-7-27/h2-6,8,10-12H,7,9,27H2,1H3,(H,29,32)(H2,30,31,33)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228569
PNG
(US9340555, 66)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCCCC3)cc2)c1
Show InChI InChI=1S/C30H32FN5O3S/c1-20-6-11-23(31)24(18-20)35-30(38)34-21-7-9-22(10-8-21)39-26-12-14-32-25-19-27(40-28(25)26)29(37)33-13-5-17-36-15-3-2-4-16-36/h6-12,14,18-19H,2-5,13,15-17H2,1H3,(H,33,37)(H2,34,35,38)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228587
PNG
(US9340555, 85)
Show SMILES CCNC(=O)c1cc2nccc(Oc3cccc(c3)C(=O)Nc3cc(C)ccc3F)c2s1
Show InChI InChI=1S/C24H20FN3O3S/c1-3-26-24(30)21-13-19-22(32-21)20(9-10-27-19)31-16-6-4-5-15(12-16)23(29)28-18-11-14(2)7-8-17(18)25/h4-13H,3H2,1-2H3,(H,26,30)(H,28,29)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228522
PNG
(US9340555, F2)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(O)=O)cc2)c1
Show InChI InChI=1S/C22H16FN3O4S/c1-12-2-7-15(23)16(10-12)26-22(29)25-13-3-5-14(6-4-13)30-18-8-9-24-17-11-19(21(27)28)31-20(17)18/h2-11H,1H3,(H,27,28)(H2,25,26,29)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228555
PNG
(US9340555, 44)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCNC(=O)OC(C)(C)C)cc2F)c1
Show InChI InChI=1S/C30H31F2N5O5S/c1-17-6-8-19(31)22(14-17)37-28(39)36-21-9-7-18(15-20(21)32)41-24-10-13-33-23-16-25(43-26(23)24)27(38)34-11-5-12-35-29(40)42-30(2,3)4/h6-10,13-16H,5,11-12H2,1-4H3,(H,34,38)(H,35,40)(H2,36,37,39)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228541
PNG
(US9340555, 27)
Show SMILES COC(=O)CN(CCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1)CC(=O)OC
Show InChI InChI=1S/C30H29F2N5O7S/c1-17-4-6-19(31)22(12-17)36-30(41)35-21-7-5-18(13-20(21)32)44-24-8-9-33-23-14-25(45-28(23)24)29(40)34-10-11-37(15-26(38)42-2)16-27(39)43-3/h4-9,12-14H,10-11,15-16H2,1-3H3,(H,34,40)(H2,35,36,41)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228559
PNG
(US9340555, 50)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCC(C3)C(O)=O)cc2F)c1
Show InChI InChI=1S/C30H29F2N5O5S/c1-17-3-5-20(31)23(13-17)36-30(41)35-22-6-4-19(14-21(22)32)42-25-7-10-33-24-15-26(43-27(24)25)28(38)34-9-2-11-37-12-8-18(16-37)29(39)40/h3-7,10,13-15,18H,2,8-9,11-12,16H2,1H3,(H,34,38)(H,39,40)(H2,35,36,41)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228578
PNG
(US9340555, 75)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(=O)NO)c1
Show InChI InChI=1S/C20H15N3O5S/c1-11-6-8-27-17(11)20(25)22-12-3-2-4-13(9-12)28-15-5-7-21-14-10-16(19(24)23-26)29-18(14)15/h2-10,26H,1H3,(H,22,25)(H,23,24)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228569
PNG
(US9340555, 66)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCCCC3)cc2)c1
Show InChI InChI=1S/C30H32FN5O3S/c1-20-6-11-23(31)24(18-20)35-30(38)34-21-7-9-22(10-8-21)39-26-12-14-32-25-19-27(40-28(25)26)29(37)33-13-5-17-36-15-3-2-4-16-36/h6-12,14,18-19H,2-5,13,15-17H2,1H3,(H,33,37)(H2,34,35,38)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228571
PNG
(US9340555, 68)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCCC3)cc2)c1
Show InChI InChI=1S/C29H30FN5O3S/c1-19-5-10-22(30)23(17-19)34-29(37)33-20-6-8-21(9-7-20)38-25-11-13-31-24-18-26(39-27(24)25)28(36)32-12-4-16-35-14-2-3-15-35/h5-11,13,17-18H,2-4,12,14-16H2,1H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228563
PNG
(US9340555, 56)
Show SMILES CCOC(=O)CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C28H27FN4O5S/c1-3-37-25(34)5-4-13-31-27(35)24-16-22-26(39-24)23(12-14-30-22)38-19-9-7-18(8-10-19)32-28(36)33-21-15-17(2)6-11-20(21)29/h6-12,14-16H,3-5,13H2,1-2H3,(H,31,35)(H2,32,33,36)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228589
PNG
(US9340555, 87)
Show SMILES COC(=O)CNCCCNC(=O)c1cc2nccc(Oc3cccc(c3)C(=O)Nc3cc(C)ccc3F)c2s1
Show InChI InChI=1S/C28H27FN4O5S/c1-17-7-8-20(29)21(13-17)33-27(35)18-5-3-6-19(14-18)38-23-9-12-31-22-15-24(39-26(22)23)28(36)32-11-4-10-30-16-25(34)37-2/h3,5-9,12-15,30H,4,10-11,16H2,1-2H3,(H,32,36)(H,33,35)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228542
PNG
(US9340555, 28)
Show SMILES COC(=O)C1CCN(C1)C(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C28H24F2N4O5S/c1-15-3-5-18(29)21(11-15)33-28(37)32-20-6-4-17(12-19(20)30)39-23-7-9-31-22-13-24(40-25(22)23)26(35)34-10-8-16(14-34)27(36)38-2/h3-7,9,11-13,16H,8,10,14H2,1-2H3,(H2,32,33,37)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228541
PNG
(US9340555, 27)
Show SMILES COC(=O)CN(CCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1)CC(=O)OC
Show InChI InChI=1S/C30H29F2N5O7S/c1-17-4-6-19(31)22(12-17)36-30(41)35-21-7-5-18(13-20(21)32)44-24-8-9-33-23-14-25(45-28(23)24)29(40)34-10-11-37(15-26(38)42-2)16-27(39)43-3/h4-9,12-14H,10-11,15-16H2,1-3H3,(H,34,40)(H2,35,36,41)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228583
PNG
(US9340555, 80)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(=O)OCCO)c1
Show InChI InChI=1S/C22H18N2O6S/c1-13-6-9-28-19(13)21(26)24-14-3-2-4-15(11-14)30-17-5-7-23-16-12-18(31-20(16)17)22(27)29-10-8-25/h2-7,9,11-12,25H,8,10H2,1H3,(H,24,26)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228544
PNG
(US9340555, 30)
Show SMILES CCOC(=O)CN1CCN(CC1)C(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C30H29F2N5O5S/c1-3-41-27(38)17-36-10-12-37(13-11-36)29(39)26-16-24-28(43-26)25(8-9-33-24)42-19-5-7-22(21(32)15-19)34-30(40)35-23-14-18(2)4-6-20(23)31/h4-9,14-16H,3,10-13,17H2,1-2H3,(H2,34,35,40)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228580
PNG
(US9340555, 77)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(=O)NCCO)c1
Show InChI InChI=1S/C22H19N3O5S/c1-13-6-10-29-19(13)22(28)25-14-3-2-4-15(11-14)30-17-5-7-23-16-12-18(31-20(16)17)21(27)24-8-9-26/h2-7,10-12,26H,8-9H2,1H3,(H,24,27)(H,25,28)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228521
PNG
(US9340555, F1)
Show SMILES COC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C23H18FN3O4S/c1-13-3-8-16(24)17(11-13)27-23(29)26-14-4-6-15(7-5-14)31-19-9-10-25-18-12-20(22(28)30-2)32-21(18)19/h3-12H,1-2H3,(H2,26,27,29)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228559
PNG
(US9340555, 50)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCC(C3)C(O)=O)cc2F)c1
Show InChI InChI=1S/C30H29F2N5O5S/c1-17-3-5-20(31)23(13-17)36-30(41)35-22-6-4-19(14-21(22)32)42-25-7-10-33-24-15-26(43-27(24)25)28(38)34-9-2-11-37-12-8-18(16-37)29(39)40/h3-7,10,13-15,18H,2,8-9,11-12,16H2,1H3,(H,34,38)(H,39,40)(H2,35,36,41)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228530
PNG
(US9340555, 13)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCc3nn[nH]n3)cc2)c1
Show InChI InChI=1S/C25H21FN8O3S/c1-14-2-7-17(26)18(12-14)30-25(36)29-15-3-5-16(6-4-15)37-20-8-10-27-19-13-21(38-23(19)20)24(35)28-11-9-22-31-33-34-32-22/h2-8,10,12-13H,9,11H2,1H3,(H,28,35)(H2,29,30,36)(H,31,32,33,34)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228557
PNG
(US9340555, 46)
Show SMILES CCNC(=O)[C@H](CCC(O)=O)NC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C29H27F2N5O6S/c1-3-32-27(39)20(8-9-25(37)38)34-28(40)24-14-22-26(43-24)23(10-11-33-22)42-16-5-7-19(18(31)13-16)35-29(41)36-21-12-15(2)4-6-17(21)30/h4-7,10-14,20H,3,8-9H2,1-2H3,(H,32,39)(H,34,40)(H,37,38)(H2,35,36,41)/t20-/m0/s1
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228584
PNG
(US9340555, 81)
Show SMILES COCCOC(=O)c1cc2nccc(Oc3cccc(NC(=O)c4occc4C)c3)c2s1
Show InChI InChI=1S/C23H20N2O6S/c1-14-7-9-29-20(14)22(26)25-15-4-3-5-16(12-15)31-18-6-8-24-17-13-19(32-21(17)18)23(27)30-11-10-28-2/h3-9,12-13H,10-11H2,1-2H3,(H,25,26)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228571
PNG
(US9340555, 68)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCCC3)cc2)c1
Show InChI InChI=1S/C29H30FN5O3S/c1-19-5-10-22(30)23(17-19)34-29(37)33-20-6-8-21(9-7-20)38-25-11-13-31-24-18-26(39-27(24)25)28(36)32-12-4-16-35-14-2-3-15-35/h5-11,13,17-18H,2-4,12,14-16H2,1H3,(H,32,36)(H2,33,34,37)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228586
PNG
(US9340555, 84)
Show SMILES Cc1ccc(F)c(NC(=O)c2cccc(Oc3ccnc4cc(sc34)C(O)=O)c2)c1
Show InChI InChI=1S/C22H15FN2O4S/c1-12-5-6-15(23)16(9-12)25-21(26)13-3-2-4-14(10-13)29-18-7-8-24-17-11-19(22(27)28)30-20(17)18/h2-11H,1H3,(H,25,26)(H,27,28)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228529
PNG
(US9340555, 12)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCc3nn[nH]n3)cc2)c1
Show InChI InChI=1S/C26H23FN8O3S/c1-15-4-9-18(27)19(13-15)31-26(37)30-16-5-7-17(8-6-16)38-21-10-12-28-20-14-22(39-24(20)21)25(36)29-11-2-3-23-32-34-35-33-23/h4-10,12-14H,2-3,11H2,1H3,(H,29,36)(H2,30,31,37)(H,32,33,34,35)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228563
PNG
(US9340555, 56)
Show SMILES CCOC(=O)CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C28H27FN4O5S/c1-3-37-25(34)5-4-13-31-27(35)24-16-22-26(39-24)23(12-14-30-22)38-19-9-7-18(8-10-19)32-28(36)33-21-15-17(2)6-11-20(21)29/h6-12,14-16H,3-5,13H2,1-2H3,(H,31,35)(H2,32,33,36)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228522
PNG
(US9340555, F2)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(O)=O)cc2)c1
Show InChI InChI=1S/C22H16FN3O4S/c1-12-2-7-15(23)16(10-12)26-22(29)25-13-3-5-14(6-4-13)30-18-8-9-24-17-11-19(21(27)28)31-20(17)18/h2-11H,1H3,(H,27,28)(H2,25,26,29)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228523
PNG
(US9340555, F3)
Show SMILES COC(=O)c1cc2nccc(Oc3cccc(NC(=O)Nc4cc(C)ccc4F)c3)c2s1
Show InChI InChI=1S/C23H18FN3O4S/c1-13-6-7-16(24)17(10-13)27-23(29)26-14-4-3-5-15(11-14)31-19-8-9-25-18-12-20(22(28)30-2)32-21(18)19/h3-12H,1-2H3,(H2,26,27,29)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228574
PNG
(US9340555, 71)
Show SMILES COC(=O)c1cc2nccc(Oc3cccc(NC(=O)c4occc4C)c3)c2s1
Show InChI InChI=1S/C21H16N2O5S/c1-12-7-9-27-18(12)20(24)23-13-4-3-5-14(10-13)28-16-6-8-22-15-11-17(21(25)26-2)29-19(15)16/h3-11H,1-2H3,(H,23,24)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228547
PNG
(US9340555, 33)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCNC(=O)OC(C)(C)C)cc2F)c1
Show InChI InChI=1S/C29H29F2N5O5S/c1-16-5-7-18(30)21(13-16)36-27(38)35-20-8-6-17(14-19(20)31)40-23-9-10-32-22-15-24(42-25(22)23)26(37)33-11-12-34-28(39)41-29(2,3)4/h5-10,13-15H,11-12H2,1-4H3,(H,33,37)(H,34,39)(H2,35,36,38)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228577
PNG
(US9340555, 74)
Show SMILES CCN(CC)C(=O)c1cc2nccc(Oc3cccc(NC(=O)c4occc4C)c3)c2s1
Show InChI InChI=1S/C24H23N3O4S/c1-4-27(5-2)24(29)20-14-18-22(32-20)19(9-11-25-18)31-17-8-6-7-16(13-17)26-23(28)21-15(3)10-12-30-21/h6-14H,4-5H2,1-3H3,(H,26,28)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228522
PNG
(US9340555, F2)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(O)=O)cc2)c1
Show InChI InChI=1S/C22H16FN3O4S/c1-12-2-7-15(23)16(10-12)26-22(29)25-13-3-5-14(6-4-13)30-18-8-9-24-17-11-19(21(27)28)31-20(17)18/h2-11H,1H3,(H,27,28)(H2,25,26,29)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228531
PNG
(US9340555, 14)
Show SMILES CCOC(=O)CN1CCN(CCCNC(=O)c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)cc4)c3s2)CC1
Show InChI InChI=1S/C33H37FN6O5S/c1-3-44-30(41)21-40-17-15-39(16-18-40)14-4-12-36-32(42)29-20-27-31(46-29)28(11-13-35-27)45-24-8-6-23(7-9-24)37-33(43)38-26-19-22(2)5-10-25(26)34/h5-11,13,19-20H,3-4,12,14-18,21H2,1-2H3,(H,36,42)(H2,37,38,43)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228561
PNG
(US9340555, 54)
Show SMILES COC(=O)CC[C@H](NC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1)C(=O)OC
Show InChI InChI=1S/C29H26F2N4O7S/c1-15-4-6-17(30)21(12-15)35-29(39)34-19-7-5-16(13-18(19)31)42-23-10-11-32-22-14-24(43-26(22)23)27(37)33-20(28(38)41-3)8-9-25(36)40-2/h4-7,10-14,20H,8-9H2,1-3H3,(H,33,37)(H2,34,35,39)/t20-/m0/s1
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228523
PNG
(US9340555, F3)
Show SMILES COC(=O)c1cc2nccc(Oc3cccc(NC(=O)Nc4cc(C)ccc4F)c3)c2s1
Show InChI InChI=1S/C23H18FN3O4S/c1-13-6-7-16(24)17(10-13)27-23(29)26-14-4-3-5-15(11-14)31-19-8-9-25-18-12-20(22(28)30-2)32-21(18)19/h3-12H,1-2H3,(H2,26,27,29)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228575
PNG
(US9340555, 72)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(O)=O)c1
Show InChI InChI=1S/C20H14N2O5S/c1-11-6-8-26-17(11)19(23)22-12-3-2-4-13(9-12)27-15-5-7-21-14-10-16(20(24)25)28-18(14)15/h2-10H,1H3,(H,22,23)(H,24,25)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228532
PNG
(US9340555, 15)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCCC(CO)C3)cc2)c1
Show InChI InChI=1S/C31H34FN5O4S/c1-20-5-10-24(32)25(16-20)36-31(40)35-22-6-8-23(9-7-22)41-27-11-13-33-26-17-28(42-29(26)27)30(39)34-12-3-15-37-14-2-4-21(18-37)19-38/h5-11,13,16-17,21,38H,2-4,12,14-15,18-19H2,1H3,(H,34,39)(H2,35,36,40)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228589
PNG
(US9340555, 87)
Show SMILES COC(=O)CNCCCNC(=O)c1cc2nccc(Oc3cccc(c3)C(=O)Nc3cc(C)ccc3F)c2s1
Show InChI InChI=1S/C28H27FN4O5S/c1-17-7-8-20(29)21(13-17)33-27(35)18-5-3-6-19(14-18)38-23-9-12-31-22-15-24(39-26(22)23)28(36)32-11-4-10-30-16-25(34)37-2/h3,5-9,12-15,30H,4,10-11,16H2,1-2H3,(H,32,36)(H,33,35)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228547
PNG
(US9340555, 33)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCNC(=O)OC(C)(C)C)cc2F)c1
Show InChI InChI=1S/C29H29F2N5O5S/c1-16-5-7-18(30)21(13-16)36-27(38)35-20-8-6-17(14-19(20)31)40-23-9-10-32-22-15-24(42-25(22)23)26(37)33-11-12-34-28(39)41-29(2,3)4/h5-10,13-15H,11-12H2,1-4H3,(H,33,37)(H,34,39)(H2,35,36,38)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228588
PNG
(US9340555, 86)
Show SMILES CCN(CC)C(=O)c1cc2nccc(Oc3cccc(c3)C(=O)Nc3cc(C)ccc3F)c2s1
Show InChI InChI=1S/C26H24FN3O3S/c1-4-30(5-2)26(32)23-15-21-24(34-23)22(11-12-28-21)33-18-8-6-7-17(14-18)25(31)29-20-13-16(3)9-10-19(20)27/h6-15H,4-5H2,1-3H3,(H,29,31)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228547
PNG
(US9340555, 33)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCNC(=O)OC(C)(C)C)cc2F)c1
Show InChI InChI=1S/C29H29F2N5O5S/c1-16-5-7-18(30)21(13-16)36-27(38)35-20-8-6-17(14-19(20)31)40-23-9-10-32-22-15-24(42-25(22)23)26(37)33-11-12-34-28(39)41-29(2,3)4/h5-10,13-15H,11-12H2,1-4H3,(H,33,37)(H,34,39)(H2,35,36,38)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228587
PNG
(US9340555, 85)
Show SMILES CCNC(=O)c1cc2nccc(Oc3cccc(c3)C(=O)Nc3cc(C)ccc3F)c2s1
Show InChI InChI=1S/C24H20FN3O3S/c1-3-26-24(30)21-13-19-22(32-21)20(9-10-27-19)31-16-6-4-5-15(12-16)23(29)28-18-11-14(2)7-8-17(18)25/h4-13H,3H2,1-2H3,(H,26,30)(H,28,29)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228559
PNG
(US9340555, 50)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCC(C3)C(O)=O)cc2F)c1
Show InChI InChI=1S/C30H29F2N5O5S/c1-17-3-5-20(31)23(13-17)36-30(41)35-22-6-4-19(14-21(22)32)42-25-7-10-33-24-15-26(43-27(24)25)28(38)34-9-2-11-37-12-8-18(16-37)29(39)40/h3-7,10,13-15,18H,2,8-9,11-12,16H2,1H3,(H,34,38)(H,39,40)(H2,35,36,41)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228586
PNG
(US9340555, 84)
Show SMILES Cc1ccc(F)c(NC(=O)c2cccc(Oc3ccnc4cc(sc34)C(O)=O)c2)c1
Show InChI InChI=1S/C22H15FN2O4S/c1-12-5-6-15(23)16(9-12)25-21(26)13-3-2-4-14(10-13)29-18-7-8-24-17-11-19(22(27)28)30-20(17)18/h2-11H,1H3,(H,25,26)(H,27,28)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228530
PNG
(US9340555, 13)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCc3nn[nH]n3)cc2)c1
Show InChI InChI=1S/C25H21FN8O3S/c1-14-2-7-17(26)18(12-14)30-25(36)29-15-3-5-16(6-4-15)37-20-8-10-27-19-13-21(38-23(19)20)24(35)28-11-9-22-31-33-34-32-22/h2-8,10,12-13H,9,11H2,1H3,(H,28,35)(H2,29,30,36)(H,31,32,33,34)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228544
PNG
(US9340555, 30)
Show SMILES CCOC(=O)CN1CCN(CC1)C(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C30H29F2N5O5S/c1-3-41-27(38)17-36-10-12-37(13-11-36)29(39)26-16-24-28(43-26)25(8-9-33-24)42-19-5-7-22(21(32)15-19)34-30(40)35-23-14-18(2)4-6-20(23)31/h4-9,14-16H,3,10-13,17H2,1-2H3,(H2,34,35,40)
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Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228529
PNG
(US9340555, 12)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCc3nn[nH]n3)cc2)c1
Show InChI InChI=1S/C26H23FN8O3S/c1-15-4-9-18(27)19(13-15)31-26(37)30-16-5-7-17(8-6-16)38-21-10-12-28-20-14-22(39-24(20)21)25(36)29-11-2-3-23-32-34-35-33-23/h4-10,12-14H,2-3,11H2,1H3,(H,29,36)(H2,30,31,37)(H,32,33,34,35)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228582
PNG
(US9340555, 79)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(=O)OCCCO)c1
Show InChI InChI=1S/C23H20N2O6S/c1-14-7-11-29-20(14)22(27)25-15-4-2-5-16(12-15)31-18-6-8-24-17-13-19(32-21(17)18)23(28)30-10-3-9-26/h2,4-8,11-13,26H,3,9-10H2,1H3,(H,25,27)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228579
PNG
(US9340555, 76)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(=O)NCCCO)c1
Show InChI InChI=1S/C23H21N3O5S/c1-14-7-11-30-20(14)23(29)26-15-4-2-5-16(12-15)31-18-6-9-24-17-13-19(32-21(17)18)22(28)25-8-3-10-27/h2,4-7,9,11-13,27H,3,8,10H2,1H3,(H,25,28)(H,26,29)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228575
PNG
(US9340555, 72)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(O)=O)c1
Show InChI InChI=1S/C20H14N2O5S/c1-11-6-8-26-17(11)19(23)22-12-3-2-4-13(9-12)27-15-5-7-21-14-10-16(20(24)25)28-18(14)15/h2-10H,1H3,(H,22,23)(H,24,25)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228574
PNG
(US9340555, 71)
Show SMILES COC(=O)c1cc2nccc(Oc3cccc(NC(=O)c4occc4C)c3)c2s1
Show InChI InChI=1S/C21H16N2O5S/c1-12-7-9-27-18(12)20(24)23-13-4-3-5-14(10-13)28-16-6-8-22-15-11-17(21(25)26-2)29-19(15)16/h3-11H,1-2H3,(H,23,24)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228576
PNG
(US9340555, 73)
Show SMILES CCNC(=O)c1cc2nccc(Oc3cccc(NC(=O)c4occc4C)c3)c2s1
Show InChI InChI=1S/C22H19N3O4S/c1-3-23-21(26)18-12-16-20(30-18)17(7-9-24-16)29-15-6-4-5-14(11-15)25-22(27)19-13(2)8-10-28-19/h4-12H,3H2,1-2H3,(H,23,26)(H,25,27)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228588
PNG
(US9340555, 86)
Show SMILES CCN(CC)C(=O)c1cc2nccc(Oc3cccc(c3)C(=O)Nc3cc(C)ccc3F)c2s1
Show InChI InChI=1S/C26H24FN3O3S/c1-4-30(5-2)26(32)23-15-21-24(34-23)22(11-12-28-21)33-18-8-6-7-17(14-18)25(31)29-20-13-16(3)9-10-19(20)27/h6-15H,4-5H2,1-3H3,(H,29,31)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228583
PNG
(US9340555, 80)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(=O)OCCO)c1
Show InChI InChI=1S/C22H18N2O6S/c1-13-6-9-28-19(13)21(26)24-14-3-2-4-15(11-14)30-17-5-7-23-16-12-18(31-20(16)17)22(27)29-10-8-25/h2-7,9,11-12,25H,8,10H2,1H3,(H,24,26)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228586
PNG
(US9340555, 84)
Show SMILES Cc1ccc(F)c(NC(=O)c2cccc(Oc3ccnc4cc(sc34)C(O)=O)c2)c1
Show InChI InChI=1S/C22H15FN2O4S/c1-12-5-6-15(23)16(9-12)25-21(26)13-3-2-4-14(10-13)29-18-7-8-24-17-11-19(22(27)28)30-20(17)18/h2-11H,1H3,(H,25,26)(H,27,28)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228585
PNG
(US9340555, 82)
Show SMILES COC(=O)CNCCCNC(=O)c1cc2nccc(Oc3cccc(NC(=O)c4occc4C)c3)c2s1
Show InChI InChI=1S/C26H26N4O6S/c1-16-8-12-35-23(16)26(33)30-17-5-3-6-18(13-17)36-20-7-11-28-19-14-21(37-24(19)20)25(32)29-10-4-9-27-15-22(31)34-2/h3,5-8,11-14,27H,4,9-10,15H2,1-2H3,(H,29,32)(H,30,33)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228584
PNG
(US9340555, 81)
Show SMILES COCCOC(=O)c1cc2nccc(Oc3cccc(NC(=O)c4occc4C)c3)c2s1
Show InChI InChI=1S/C23H20N2O6S/c1-14-7-9-29-20(14)22(26)25-15-4-3-5-16(12-15)31-18-6-8-24-17-13-19(32-21(17)18)23(27)30-11-10-28-2/h3-9,12-13H,10-11H2,1-2H3,(H,25,26)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228578
PNG
(US9340555, 75)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(=O)NO)c1
Show InChI InChI=1S/C20H15N3O5S/c1-11-6-8-27-17(11)20(25)22-12-3-2-4-13(9-12)28-15-5-7-21-14-10-16(19(24)23-26)29-18(14)15/h2-10,26H,1H3,(H,22,25)(H,23,24)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228581
PNG
(US9340555, 78)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(=O)NCCc2nn[nH]n2)c1
Show InChI InChI=1S/C23H19N7O4S/c1-13-7-10-33-20(13)23(32)26-14-3-2-4-15(11-14)34-17-5-8-24-16-12-18(35-21(16)17)22(31)25-9-6-19-27-29-30-28-19/h2-5,7-8,10-12H,6,9H2,1H3,(H,25,31)(H,26,32)(H,27,28,29,30)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228557
PNG
(US9340555, 46)
Show SMILES CCNC(=O)[C@H](CCC(O)=O)NC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(F)c3)c2s1
Show InChI InChI=1S/C29H27F2N5O6S/c1-3-32-27(39)20(8-9-25(37)38)34-28(40)24-14-22-26(43-24)23(10-11-33-22)42-16-5-7-19(18(31)13-16)35-29(41)36-21-12-15(2)4-6-17(21)30/h4-7,10-14,20H,3,8-9H2,1-2H3,(H,32,39)(H,34,40)(H,37,38)(H2,35,36,41)/t20-/m0/s1
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228580
PNG
(US9340555, 77)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(=O)NCCO)c1
Show InChI InChI=1S/C22H19N3O5S/c1-13-6-10-29-19(13)22(28)25-14-3-2-4-15(11-14)30-17-5-7-23-16-12-18(31-20(16)17)21(27)24-8-9-26/h2-7,10-12,26H,8-9H2,1H3,(H,24,27)(H,25,28)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228577
PNG
(US9340555, 74)
Show SMILES CCN(CC)C(=O)c1cc2nccc(Oc3cccc(NC(=O)c4occc4C)c3)c2s1
Show InChI InChI=1S/C24H23N3O4S/c1-4-27(5-2)24(29)20-14-18-22(32-20)19(9-11-25-18)31-17-8-6-7-16(13-17)26-23(28)21-15(3)10-12-30-21/h6-14H,4-5H2,1-3H3,(H,26,28)
PDB
MMDB

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PC sid
UniChem
US Patent
n/an/a 424n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM228575
PNG
(US9340555, 72)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(Oc2ccnc3cc(sc23)C(O)=O)c1
Show InChI InChI=1S/C20H14N2O5S/c1-11-6-8-26-17(11)19(23)22-12-3-2-4-13(9-12)27-15-5-7-21-14-10-16(20(24)25)28-18(14)15/h2-10H,1H3,(H,22,23)(H,24,25)
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UniChem
US Patent
n/an/a 920n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228525
PNG
(US9340555, F5)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2ccnc3cc(sc23)C(O)=O)c1
Show InChI InChI=1S/C22H16FN3O3S/c1-12-2-7-16(23)17(10-12)26-22(29)25-14-5-3-13(4-6-14)15-8-9-24-18-11-19(21(27)28)30-20(15)18/h2-11H,1H3,(H,27,28)(H2,25,26,29)
PDB
MMDB

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UniChem
US Patent
n/an/a 1.00E+5n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228524
PNG
(US9340555, F4)
Show SMILES COC(=O)c1cc2nccc(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C23H18FN3O3S/c1-13-3-8-17(24)18(11-13)27-23(29)26-15-6-4-14(5-7-15)16-9-10-25-19-12-20(22(28)30-2)31-21(16)19/h3-12H,1-2H3,(H2,26,27,29)
PDB
MMDB

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UniChem
US Patent
n/an/a 1.00E+5n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228525
PNG
(US9340555, F5)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2ccnc3cc(sc23)C(O)=O)c1
Show InChI InChI=1S/C22H16FN3O3S/c1-12-2-7-16(23)17(10-12)26-22(29)25-14-5-3-13(4-6-14)15-8-9-24-18-11-19(21(27)28)30-20(15)18/h2-11H,1H3,(H,27,28)(H2,25,26,29)
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US Patent
n/an/a 1.00E+5n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM228524
PNG
(US9340555, F4)
Show SMILES COC(=O)c1cc2nccc(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1
Show InChI InChI=1S/C23H18FN3O3S/c1-13-3-8-17(24)18(11-13)27-23(29)26-15-6-4-14(5-7-15)16-9-10-25-19-12-20(22(28)30-2)31-21(16)19/h3-12H,1-2H3,(H2,26,27,29)
PDB
MMDB

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UniChem
US Patent
n/an/a 1.00E+5n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%