BindingDB logo
myBDB logout

Patent code US9346782

Compile Data Set for Download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231231
PNG
(US9346782, 11a | US9346782, 11b | US9346782, 11c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnnn1C
Show InChI InChI=1S/C23H20ClF3N4O2/c1-22(32,19-12-28-30-31(19)2)15-8-9-18-16(11-15)20(24)17(21(29-18)33-3)10-13-4-6-14(7-5-13)23(25,26)27/h4-9,11-12,32H,10H2,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231232
PNG
(US9346782, 12a | US9346782, 12b | US9346782, 12c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnc(C)n1C
Show InChI InChI=1S/C25H23ClF3N3O2/c1-14-30-13-21(32(14)3)24(2,33)17-9-10-20-18(12-17)22(26)19(23(31-20)34-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12-13,33H,11H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 41n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231233
PNG
(US9346782, 13a | US9346782, 13b | US9346782, 13c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1ccc(C)nc1C
Show InChI InChI=1S/C27H24ClF3N2O2/c1-15-5-11-22(16(2)32-15)26(3,34)19-10-12-23-20(14-19)24(28)21(25(33-23)35-4)13-17-6-8-18(9-7-17)27(29,30)31/h5-12,14,34H,13H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 46n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231233
PNG
(US9346782, 13a | US9346782, 13b | US9346782, 13c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1ccc(C)nc1C
Show InChI InChI=1S/C27H24ClF3N2O2/c1-15-5-11-22(16(2)32-15)26(3,34)19-10-12-23-20(14-19)24(28)21(25(33-23)35-4)13-17-6-8-18(9-7-17)27(29,30)31/h5-12,14,34H,13H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 52n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231234
PNG
(US9346782, 14a | US9346782, 14b | US9346782, 14c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)c1cnc(C)n1C
Show InChI InChI=1S/C26H21ClF3N3O2/c1-5-25(34,22-14-31-15(2)33(22)3)18-10-11-21-19(13-18)23(27)20(24(32-21)35-4)12-16-6-8-17(9-7-16)26(28,29)30/h1,6-11,13-14,34H,12H2,2-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 66n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231227
PNG
(US9346782, 7a | US9346782, 7b | US9346782, 7c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)C1CN(C1)C(C)=O
Show InChI InChI=1S/C26H22ClF3N2O3/c1-4-25(34,19-13-32(14-19)15(2)33)18-9-10-22-20(12-18)23(27)21(24(31-22)35-3)11-16-5-7-17(8-6-16)26(28,29)30/h1,5-10,12,19,34H,11,13-14H2,2-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 98n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231231
PNG
(US9346782, 11a | US9346782, 11b | US9346782, 11c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnnn1C
Show InChI InChI=1S/C23H20ClF3N4O2/c1-22(32,19-12-28-30-31(19)2)15-8-9-18-16(11-15)20(24)17(21(29-18)33-3)10-13-4-6-14(7-5-13)23(25,26)27/h4-9,11-12,32H,10H2,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231221
PNG
(US9346782, 1)
Show SMILES CCCCC(O)(c1cc(C)no1)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1
Show InChI InChI=1S/C24H22Cl2N2O2/c1-3-4-12-24(29,20-13-15(2)28-30-20)17-10-11-19-18(14-17)22(25)21(23(26)27-19)16-8-6-5-7-9-16/h5-11,13-14,29H,3-4,12H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 150n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231229
PNG
(US9346782, 9a | US9346782, 9b | US9346782, 9c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cncn1C
Show InChI InChI=1S/C24H21ClF3N3O2/c1-23(32,20-12-29-13-31(20)2)16-8-9-19-17(11-16)21(25)18(22(30-19)33-3)10-14-4-6-15(7-5-14)24(26,27)28/h4-9,11-13,32H,10H2,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 180n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231233
PNG
(US9346782, 13a | US9346782, 13b | US9346782, 13c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1ccc(C)nc1C
Show InChI InChI=1S/C27H24ClF3N2O2/c1-15-5-11-22(16(2)32-15)26(3,34)19-10-12-23-20(14-19)24(28)21(25(33-23)35-4)13-17-6-8-18(9-7-17)27(29,30)31/h5-12,14,34H,13H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231234
PNG
(US9346782, 14a | US9346782, 14b | US9346782, 14c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)c1cnc(C)n1C
Show InChI InChI=1S/C26H21ClF3N3O2/c1-5-25(34,22-14-31-15(2)33(22)3)18-10-11-21-19(13-18)23(27)20(24(32-21)35-4)12-16-6-8-17(9-7-16)26(28,29)30/h1,6-11,13-14,34H,12H2,2-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 210n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231231
PNG
(US9346782, 11a | US9346782, 11b | US9346782, 11c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnnn1C
Show InChI InChI=1S/C23H20ClF3N4O2/c1-22(32,19-12-28-30-31(19)2)15-8-9-18-16(11-15)20(24)17(21(29-18)33-3)10-13-4-6-14(7-5-13)23(25,26)27/h4-9,11-12,32H,10H2,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 210n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231227
PNG
(US9346782, 7a | US9346782, 7b | US9346782, 7c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)C1CN(C1)C(C)=O
Show InChI InChI=1S/C26H22ClF3N2O3/c1-4-25(34,19-13-32(14-19)15(2)33)18-9-10-22-20(12-18)23(27)21(24(31-22)35-3)11-16-5-7-17(8-6-16)26(28,29)30/h1,5-10,12,19,34H,11,13-14H2,2-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 230n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231230
PNG
(US9346782, 10a | US9346782, 10b | US9346782, 10c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1oc(C)nc1C
Show InChI InChI=1S/C25H22ClF3N2O3/c1-13-22(34-14(2)30-13)24(3,32)17-9-10-20-18(12-17)21(26)19(23(31-20)33-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12,32H,11H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 250n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231230
PNG
(US9346782, 10a | US9346782, 10b | US9346782, 10c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1oc(C)nc1C
Show InChI InChI=1S/C25H22ClF3N2O3/c1-13-22(34-14(2)30-13)24(3,32)17-9-10-20-18(12-17)21(26)19(23(31-20)33-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12,32H,11H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 260n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231229
PNG
(US9346782, 9a | US9346782, 9b | US9346782, 9c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cncn1C
Show InChI InChI=1S/C24H21ClF3N3O2/c1-23(32,20-12-29-13-31(20)2)16-8-9-19-17(11-16)21(25)18(22(30-19)33-3)10-14-4-6-15(7-5-14)24(26,27)28/h4-9,11-13,32H,10H2,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 280n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231234
PNG
(US9346782, 14a | US9346782, 14b | US9346782, 14c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)c1cnc(C)n1C
Show InChI InChI=1S/C26H21ClF3N3O2/c1-5-25(34,22-14-31-15(2)33(22)3)18-10-11-21-19(13-18)23(27)20(24(32-21)35-4)12-16-6-8-17(9-7-16)26(28,29)30/h1,6-11,13-14,34H,12H2,2-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 310n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231230
PNG
(US9346782, 10a | US9346782, 10b | US9346782, 10c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1oc(C)nc1C
Show InChI InChI=1S/C25H22ClF3N2O3/c1-13-22(34-14(2)30-13)24(3,32)17-9-10-20-18(12-17)21(26)19(23(31-20)33-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12,32H,11H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 330n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231227
PNG
(US9346782, 7a | US9346782, 7b | US9346782, 7c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)C1CN(C1)C(C)=O
Show InChI InChI=1S/C26H22ClF3N2O3/c1-4-25(34,19-13-32(14-19)15(2)33)18-9-10-22-20(12-18)23(27)21(24(31-22)35-3)11-16-5-7-17(8-6-16)26(28,29)30/h1,5-10,12,19,34H,11,13-14H2,2-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 360n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231232
PNG
(US9346782, 12a | US9346782, 12b | US9346782, 12c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnc(C)n1C
Show InChI InChI=1S/C25H23ClF3N3O2/c1-14-30-13-21(32(14)3)24(2,33)17-9-10-20-18(12-17)22(26)19(23(31-20)34-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12-13,33H,11H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 370n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231222
PNG
(US9346782, 2)
Show SMILES CCC(O)(c1cc(C)no1)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1
Show InChI InChI=1S/C22H18Cl2N2O2/c1-3-22(27,18-11-13(2)26-28-18)15-9-10-17-16(12-15)20(23)19(21(24)25-17)14-7-5-4-6-8-14/h4-12,27H,3H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 450n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231232
PNG
(US9346782, 12a | US9346782, 12b | US9346782, 12c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnc(C)n1C
Show InChI InChI=1S/C25H23ClF3N3O2/c1-14-30-13-21(32(14)3)24(2,33)17-9-10-20-18(12-17)22(26)19(23(31-20)34-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12-13,33H,11H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231237
PNG
(US9346782, 17)
Show SMILES CCC(O)(C1CN(C1)C(=O)OC(C)(C)C)c1ccc2nc(OC)c(Cc3ccc(cc3)C(F)(F)F)c(Cl)c2c1
Show InChI InChI=1S/C29H32ClF3N2O4/c1-6-28(37,20-15-35(16-20)26(36)39-27(2,3)4)19-11-12-23-21(14-19)24(30)22(25(34-23)38-5)13-17-7-9-18(10-8-17)29(31,32)33/h7-12,14,20,37H,6,13,15-16H2,1-5H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231235
PNG
(US9346782, 15)
Show SMILES CC(C)C(O)(c1sc(C)nc1C)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1
Show InChI InChI=1S/C24H22Cl2N2OS/c1-13(2)24(29,22-14(3)27-15(4)30-22)17-10-11-19-18(12-17)21(25)20(23(26)28-19)16-8-6-5-7-9-16/h5-13,29H,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231225
PNG
(US9346782, 5)
Show SMILES CC(C)C(O)(c1cncn1C)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1
Show InChI InChI=1S/C23H21Cl2N3O/c1-14(2)23(29,19-12-26-13-28(19)3)16-9-10-18-17(11-16)21(24)20(22(25)27-18)15-7-5-4-6-8-15/h4-14,29H,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231229
PNG
(US9346782, 9a | US9346782, 9b | US9346782, 9c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cncn1C
Show InChI InChI=1S/C24H21ClF3N3O2/c1-23(32,20-12-29-13-31(20)2)16-8-9-19-17(11-16)21(25)18(22(30-19)33-3)10-14-4-6-15(7-5-14)24(26,27)28/h4-9,11-13,32H,10H2,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231224
PNG
(US9346782, 4)
Show SMILES CCCCC(O)(c1cncn1C)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1
Show InChI InChI=1S/C24H23Cl2N3O/c1-3-4-12-24(30,20-14-27-15-29(20)2)17-10-11-19-18(13-17)22(25)21(23(26)28-19)16-8-6-5-7-9-16/h5-11,13-15,30H,3-4,12H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231226
PNG
(US9346782, 6)
Show SMILES CCC(O)(c1cncn1C)c1ccc2nc(OC)c(Cc3ccc(cc3)S(C)(=O)=O)c(Cl)c2c1
Show InChI InChI=1S/C25H26ClN3O4S/c1-5-25(30,22-14-27-15-29(22)2)17-8-11-21-19(13-17)23(26)20(24(28-21)33-3)12-16-6-9-18(10-7-16)34(4,31)32/h6-11,13-15,30H,5,12H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.70E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231228
PNG
(US9346782, 8)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)C1CN(C1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H28ClF3N2O4/c1-6-28(37,20-15-35(16-20)26(36)39-27(2,3)4)19-11-12-23-21(14-19)24(30)22(25(34-23)38-5)13-17-7-9-18(10-8-17)29(31,32)33/h1,7-12,14,20,37H,13,15-16H2,2-5H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.00E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231223
PNG
(US9346782, 3)
Show SMILES Cn1cncc1C(O)(C1CC1)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1
Show InChI InChI=1S/C23H19Cl2N3O/c1-28-13-26-12-19(28)23(29,15-7-8-15)16-9-10-18-17(11-16)21(24)20(22(25)27-18)14-5-3-2-4-6-14/h2-6,9-13,15,29H,7-8H2,1H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>6.00E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231235
PNG
(US9346782, 15)
Show SMILES CC(C)C(O)(c1sc(C)nc1C)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1
Show InChI InChI=1S/C24H22Cl2N2OS/c1-13(2)24(29,22-14(3)27-15(4)30-22)17-10-11-19-18(12-17)21(25)20(23(26)28-19)16-8-6-5-7-9-16/h5-13,29H,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 98n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231231
PNG
(US9346782, 11a | US9346782, 11b | US9346782, 11c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnnn1C
Show InChI InChI=1S/C23H20ClF3N4O2/c1-22(32,19-12-28-30-31(19)2)15-8-9-18-16(11-15)20(24)17(21(29-18)33-3)10-13-4-6-14(7-5-13)23(25,26)27/h4-9,11-12,32H,10H2,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 290n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231229
PNG
(US9346782, 9a | US9346782, 9b | US9346782, 9c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cncn1C
Show InChI InChI=1S/C24H21ClF3N3O2/c1-23(32,20-12-29-13-31(20)2)16-8-9-19-17(11-16)21(25)18(22(30-19)33-3)10-14-4-6-15(7-5-14)24(26,27)28/h4-9,11-13,32H,10H2,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 540n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231227
PNG
(US9346782, 7a | US9346782, 7b | US9346782, 7c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)C1CN(C1)C(C)=O
Show InChI InChI=1S/C26H22ClF3N2O3/c1-4-25(34,19-13-32(14-19)15(2)33)18-9-10-22-20(12-18)23(27)21(24(31-22)35-3)11-16-5-7-17(8-6-16)26(28,29)30/h1,5-10,12,19,34H,11,13-14H2,2-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 49n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231225
PNG
(US9346782, 5)
Show SMILES CC(C)C(O)(c1cncn1C)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1
Show InChI InChI=1S/C23H21Cl2N3O/c1-14(2)23(29,19-12-26-13-28(19)3)16-9-10-18-17(11-16)21(24)20(22(25)27-18)15-7-5-4-6-8-15/h4-14,29H,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 620n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231221
PNG
(US9346782, 1)
Show SMILES CCCCC(O)(c1cc(C)no1)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1
Show InChI InChI=1S/C24H22Cl2N2O2/c1-3-4-12-24(29,20-13-15(2)28-30-20)17-10-11-19-18(14-17)22(25)21(23(26)27-19)16-8-6-5-7-9-16/h5-11,13-14,29H,3-4,12H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 240n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231233
PNG
(US9346782, 13a | US9346782, 13b | US9346782, 13c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1ccc(C)nc1C
Show InChI InChI=1S/C27H24ClF3N2O2/c1-15-5-11-22(16(2)32-15)26(3,34)19-10-12-23-20(14-19)24(28)21(25(33-23)35-4)13-17-6-8-18(9-7-17)27(29,30)31/h5-12,14,34H,13H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 71n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231233
PNG
(US9346782, 13a | US9346782, 13b | US9346782, 13c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1ccc(C)nc1C
Show InChI InChI=1S/C27H24ClF3N2O2/c1-15-5-11-22(16(2)32-15)26(3,34)19-10-12-23-20(14-19)24(28)21(25(33-23)35-4)13-17-6-8-18(9-7-17)27(29,30)31/h5-12,14,34H,13H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 59n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231232
PNG
(US9346782, 12a | US9346782, 12b | US9346782, 12c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnc(C)n1C
Show InChI InChI=1S/C25H23ClF3N3O2/c1-14-30-13-21(32(14)3)24(2,33)17-9-10-20-18(12-17)22(26)19(23(31-20)34-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12-13,33H,11H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 27n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231231
PNG
(US9346782, 11a | US9346782, 11b | US9346782, 11c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnnn1C
Show InChI InChI=1S/C23H20ClF3N4O2/c1-22(32,19-12-28-30-31(19)2)15-8-9-18-16(11-15)20(24)17(21(29-18)33-3)10-13-4-6-14(7-5-13)23(25,26)27/h4-9,11-12,32H,10H2,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 77n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231233
PNG
(US9346782, 13a | US9346782, 13b | US9346782, 13c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1ccc(C)nc1C
Show InChI InChI=1S/C27H24ClF3N2O2/c1-15-5-11-22(16(2)32-15)26(3,34)19-10-12-23-20(14-19)24(28)21(25(33-23)35-4)13-17-6-8-18(9-7-17)27(29,30)31/h5-12,14,34H,13H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 21n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231232
PNG
(US9346782, 12a | US9346782, 12b | US9346782, 12c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnc(C)n1C
Show InChI InChI=1S/C25H23ClF3N3O2/c1-14-30-13-21(32(14)3)24(2,33)17-9-10-20-18(12-17)22(26)19(23(31-20)34-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12-13,33H,11H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 470n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231234
PNG
(US9346782, 14a | US9346782, 14b | US9346782, 14c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)c1cnc(C)n1C
Show InChI InChI=1S/C26H21ClF3N3O2/c1-5-25(34,22-14-31-15(2)33(22)3)18-10-11-21-19(13-18)23(27)20(24(32-21)35-4)12-16-6-8-17(9-7-16)26(28,29)30/h1,6-11,13-14,34H,12H2,2-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 130n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231231
PNG
(US9346782, 11a | US9346782, 11b | US9346782, 11c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnnn1C
Show InChI InChI=1S/C23H20ClF3N4O2/c1-22(32,19-12-28-30-31(19)2)15-8-9-18-16(11-15)20(24)17(21(29-18)33-3)10-13-4-6-14(7-5-13)23(25,26)27/h4-9,11-12,32H,10H2,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 36n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231230
PNG
(US9346782, 10a | US9346782, 10b | US9346782, 10c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1oc(C)nc1C
Show InChI InChI=1S/C25H22ClF3N2O3/c1-13-22(34-14(2)30-13)24(3,32)17-9-10-20-18(12-17)21(26)19(23(31-20)33-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12,32H,11H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 140n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231234
PNG
(US9346782, 14a | US9346782, 14b | US9346782, 14c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)c1cnc(C)n1C
Show InChI InChI=1S/C26H21ClF3N3O2/c1-5-25(34,22-14-31-15(2)33(22)3)18-10-11-21-19(13-18)23(27)20(24(32-21)35-4)12-16-6-8-17(9-7-16)26(28,29)30/h1,6-11,13-14,34H,12H2,2-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 60n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231222
PNG
(US9346782, 2)
Show SMILES CCC(O)(c1cc(C)no1)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1
Show InChI InChI=1S/C22H18Cl2N2O2/c1-3-22(27,18-11-13(2)26-28-18)15-9-10-17-16(12-15)20(23)19(21(24)25-17)14-7-5-4-6-8-14/h4-12,27H,3H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 520n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231232
PNG
(US9346782, 12a | US9346782, 12b | US9346782, 12c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnc(C)n1C
Show InChI InChI=1S/C25H23ClF3N3O2/c1-14-30-13-21(32(14)3)24(2,33)17-9-10-20-18(12-17)22(26)19(23(31-20)34-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12-13,33H,11H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 15n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231226
PNG
(US9346782, 6)
Show SMILES CCC(O)(c1cncn1C)c1ccc2nc(OC)c(Cc3ccc(cc3)S(C)(=O)=O)c(Cl)c2c1
Show InChI InChI=1S/C25H26ClN3O4S/c1-5-25(30,22-14-27-15-29(22)2)17-8-11-21-19(13-17)23(26)20(24(28-21)33-3)12-16-6-9-18(10-7-16)34(4,31)32/h6-11,13-15,30H,5,12H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 1.50E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231237
PNG
(US9346782, 17)
Show SMILES CCC(O)(C1CN(C1)C(=O)OC(C)(C)C)c1ccc2nc(OC)c(Cc3ccc(cc3)C(F)(F)F)c(Cl)c2c1
Show InChI InChI=1S/C29H32ClF3N2O4/c1-6-28(37,20-15-35(16-20)26(36)39-27(2,3)4)19-11-12-23-21(14-19)24(30)22(25(34-23)38-5)13-17-7-9-18(10-8-17)29(31,32)33/h7-12,14,20,37H,6,13,15-16H2,1-5H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 390n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231234
PNG
(US9346782, 14a | US9346782, 14b | US9346782, 14c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)c1cnc(C)n1C
Show InChI InChI=1S/C26H21ClF3N3O2/c1-5-25(34,22-14-31-15(2)33(22)3)18-10-11-21-19(13-18)23(27)20(24(32-21)35-4)12-16-6-8-17(9-7-16)26(28,29)30/h1,6-11,13-14,34H,12H2,2-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 59n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231230
PNG
(US9346782, 10a | US9346782, 10b | US9346782, 10c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1oc(C)nc1C
Show InChI InChI=1S/C25H22ClF3N2O3/c1-13-22(34-14(2)30-13)24(3,32)17-9-10-20-18(12-17)21(26)19(23(31-20)33-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12,32H,11H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 130n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231229
PNG
(US9346782, 9a | US9346782, 9b | US9346782, 9c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cncn1C
Show InChI InChI=1S/C24H21ClF3N3O2/c1-23(32,20-12-29-13-31(20)2)16-8-9-19-17(11-16)21(25)18(22(30-19)33-3)10-14-4-6-15(7-5-14)24(26,27)28/h4-9,11-13,32H,10H2,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 290n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231227
PNG
(US9346782, 7a | US9346782, 7b | US9346782, 7c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)C1CN(C1)C(C)=O
Show InChI InChI=1S/C26H22ClF3N2O3/c1-4-25(34,19-13-32(14-19)15(2)33)18-9-10-22-20(12-18)23(27)21(24(31-22)35-3)11-16-5-7-17(8-6-16)26(28,29)30/h1,5-10,12,19,34H,11,13-14H2,2-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 300n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231223
PNG
(US9346782, 3)
Show SMILES Cn1cncc1C(O)(C1CC1)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1
Show InChI InChI=1S/C23H19Cl2N3O/c1-28-13-26-12-19(28)23(29,15-7-8-15)16-9-10-18-17(11-16)21(24)20(22(25)27-18)14-5-3-2-4-6-14/h2-6,9-13,15,29H,7-8H2,1H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 890n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231230
PNG
(US9346782, 10a | US9346782, 10b | US9346782, 10c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1oc(C)nc1C
Show InChI InChI=1S/C25H22ClF3N2O3/c1-13-22(34-14(2)30-13)24(3,32)17-9-10-20-18(12-17)21(26)19(23(31-20)33-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12,32H,11H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 140n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231229
PNG
(US9346782, 9a | US9346782, 9b | US9346782, 9c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cncn1C
Show InChI InChI=1S/C24H21ClF3N3O2/c1-23(32,20-12-29-13-31(20)2)16-8-9-19-17(11-16)21(25)18(22(30-19)33-3)10-14-4-6-15(7-5-14)24(26,27)28/h4-9,11-13,32H,10H2,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 54n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231228
PNG
(US9346782, 8)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)C1CN(C1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H28ClF3N2O4/c1-6-28(37,20-15-35(16-20)26(36)39-27(2,3)4)19-11-12-23-21(14-19)24(30)22(25(34-23)38-5)13-17-7-9-18(10-8-17)29(31,32)33/h1,7-12,14,20,37H,13,15-16H2,2-5H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 3.10E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231224
PNG
(US9346782, 4)
Show SMILES CCCCC(O)(c1cncn1C)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1
Show InChI InChI=1S/C24H23Cl2N3O/c1-3-4-12-24(30,20-14-27-15-29(20)2)17-10-11-19-18(13-17)22(25)21(23(26)28-19)16-8-6-5-7-9-16/h5-11,13-15,30H,3-4,12H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 1.10E+3n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
Retinoic acid-related nuclear receptor gamma t (RORγt)


(Artificial Sequence)
BDBM231227
PNG
(US9346782, 7a | US9346782, 7b | US9346782, 7c)
Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)C1CN(C1)C(C)=O
Show InChI InChI=1S/C26H22ClF3N2O3/c1-4-25(34,19-13-32(14-19)15(2)33)18-9-10-22-20(12-18)23(27)21(24(31-22)35-3)11-16-5-7-17(8-6-16)26(28,29)30/h1,5-10,12,19,34H,11,13-14H2,2-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 230n/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%