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Patent code US9346798

Compile Data Set for Download or QSAR

Found 678 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231260
PNG
(US9346798, 7)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(c1)C1=CCNCC1
Show InChI InChI=1S/C22H20F3N5O3S2/c23-22(24,25)15-1-3-18(17(11-15)14-5-7-26-8-6-14)30-9-10-33-20-12-16(2-4-19(20)30)35(31,32)29-21-27-13-28-34-21/h1-5,11-13,26H,6-10H2,(H,27,28,29)
PDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231305
PNG
(US9346798, 52)
Show SMILES Clc1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C1=CCNCC1
Show InChI InChI=1S/C22H21ClN4O3S2/c23-16-1-3-19(18(13-16)15-5-7-24-8-6-15)27-10-11-30-21-14-17(2-4-20(21)27)32(28,29)26-22-25-9-12-31-22/h1-5,9,12-14,24H,6-8,10-11H2,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231304
PNG
(US9346798, 51)
Show SMILES CN1CCC(=CC1)c1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1ccncn1)C(F)(F)F
Show InChI InChI=1S/C25H24F3N5O3S/c1-32-10-7-17(8-11-32)20-14-18(25(26,27)28)2-4-21(20)33-12-13-36-23-15-19(3-5-22(23)33)37(34,35)31-24-6-9-29-16-30-24/h2-7,9,14-16H,8,10-13H2,1H3,(H,29,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231464
PNG
(US9346798, 211)
Show SMILES OCCc1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C20H18F3N3O4S2/c21-20(22,23)14-1-3-16(13(11-14)5-8-27)26-7-9-30-18-12-15(2-4-17(18)26)32(28,29)25-19-24-6-10-31-19/h1-4,6,10-12,27H,5,7-9H2,(H,24,25)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231298
PNG
(US9346798, 45)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ccncn2)c(c1)C1=CCNCC1
Show InChI InChI=1S/C24H22F3N5O3S/c25-24(26,27)17-1-3-20(19(13-17)16-5-8-28-9-6-16)32-11-12-35-22-14-18(2-4-21(22)32)36(33,34)31-23-7-10-29-15-30-23/h1-5,7,10,13-15,28H,6,8-9,11-12H2,(H,29,30,31)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 6.20n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231434
PNG
(US9346798, 181)
Show SMILES COc1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N
Show InChI InChI=1S/C19H16N4O4S2/c1-26-17-10-13(12-20)2-4-15(17)23-7-8-27-18-11-14(3-5-16(18)23)29(24,25)22-19-21-6-9-28-19/h2-6,9-11H,7-8H2,1H3,(H,21,22)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 7.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231255
PNG
(US9346798, 2)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(Cl)c1
Show InChI InChI=1S/C17H12ClF3N4O3S2/c18-12-7-10(17(19,20)21)1-3-13(12)25-5-6-28-15-8-11(2-4-14(15)25)30(26,27)24-16-22-9-23-29-16/h1-4,7-9H,5-6H2,(H,22,23,24)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 7.83n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231470
PNG
(US9346798, 217)
Show SMILES COc1cc(ccc1N1CCOc2cc(c(F)cc12)S(=O)(=O)Nc1nccs1)C#N
Show InChI InChI=1S/C19H15FN4O4S2/c1-27-16-8-12(11-21)2-3-14(16)24-5-6-28-17-10-18(13(20)9-15(17)24)30(25,26)23-19-22-4-7-29-19/h2-4,7-10H,5-6H2,1H3,(H,22,23)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231347
PNG
(US9346798, 94)
Show SMILES C[C@H]1CN(c2ccc(cc2O1)S(=O)(=O)Nc1nccs1)c1ccc(cc1C#N)C(F)(F)F
Show InChI InChI=1S/C20H15F3N4O3S2/c1-12-11-27(16-4-2-14(20(21,22)23)8-13(16)10-24)17-5-3-15(9-18(17)30-12)32(28,29)26-19-25-6-7-31-19/h2-9,12H,11H2,1H3,(H,25,26)/t12-/m0/s1
PDB

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PC sid
UniChem
US Patent
n/an/a 8.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231257
PNG
(US9346798, 4)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(c1)-c1cn[nH]c1
Show InChI InChI=1S/C20H15F3N6O3S2/c21-20(22,23)13-1-3-16(15(7-13)12-9-25-26-10-12)29-5-6-32-18-8-14(2-4-17(18)29)34(30,31)28-19-24-11-27-33-19/h1-4,7-11H,5-6H2,(H,25,26)(H,24,27,28)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 9.33n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231282
PNG
(US9346798, 29)
Show SMILES Nc1cc(ccn1)-c1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F
Show InChI InChI=1S/C22H17F3N6O3S2/c23-22(24,25)14-1-3-17(16(10-14)13-5-6-27-20(26)9-13)31-7-8-34-19-11-15(2-4-18(19)31)36(32,33)30-21-28-12-29-35-21/h1-6,9-12H,7-8H2,(H2,26,27)(H,28,29,30)
PDB

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UniProtKB/SwissProt

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GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 9.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231468
PNG
(US9346798, 215)
Show SMILES Fc1cc2N(CCOc2cc1S(=O)(=O)Nc1nccs1)c1ccc(cc1C#N)C(F)(F)F
Show InChI InChI=1S/C19H12F4N4O3S2/c20-13-8-15-16(9-17(13)32(28,29)26-18-25-3-6-31-18)30-5-4-27(15)14-2-1-12(19(21,22)23)7-11(14)10-24/h1-3,6-9H,4-5H2,(H,25,26)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 9.86n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231279
PNG
(US9346798, 26)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(c1)-c1ccncc1
Show InChI InChI=1S/C22H16F3N5O3S2/c23-22(24,25)15-1-3-18(17(11-15)14-5-7-26-8-6-14)30-9-10-33-20-12-16(2-4-19(20)30)35(31,32)29-21-27-13-28-34-21/h1-8,11-13H,9-10H2,(H,27,28,29)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 10.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231275
PNG
(US9346798, 22)
Show SMILES CN1CCC(=CC1)c1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F
Show InChI InChI=1S/C23H22F3N5O3S2/c1-30-8-6-15(7-9-30)18-12-16(23(24,25)26)2-4-19(18)31-10-11-34-21-13-17(3-5-20(21)31)36(32,33)29-22-27-14-28-35-22/h2-6,12-14H,7-11H2,1H3,(H,27,28,29)
PDB

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UniProtKB/SwissProt

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DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 10.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231256
PNG
(US9346798, 3)
Show SMILES Cn1nccc1-c1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F
Show InChI InChI=1S/C21H17F3N6O3S2/c1-29-16(6-7-26-29)15-10-13(21(22,23)24)2-4-17(15)30-8-9-33-19-11-14(3-5-18(19)30)35(31,32)28-20-25-12-27-34-20/h2-7,10-12H,8-9H2,1H3,(H,25,27,28)
PDB

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UniProtKB/SwissProt

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DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 10.8n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231254
PNG
(US9346798, 1)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(Br)c1
Show InChI InChI=1S/C17H12BrF3N4O3S2/c18-12-7-10(17(19,20)21)1-3-13(12)25-5-6-28-15-8-11(2-4-14(15)25)30(26,27)24-16-22-9-23-29-16/h1-4,7-9H,5-6H2,(H,22,23,24)
PDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 11.3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231439
PNG
(US9346798, 186)
Show SMILES COc1cc(Cl)ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H16ClN3O4S2/c1-25-16-10-12(19)2-4-14(16)22-7-8-26-17-11-13(3-5-15(17)22)28(23,24)21-18-20-6-9-27-18/h2-6,9-11H,7-8H2,1H3,(H,20,21)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 11.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231307
PNG
(US9346798, 54)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)-c1cncnc1
Show InChI InChI=1S/C22H16F3N5O3S2/c23-22(24,25)15-1-3-18(17(9-15)14-11-26-13-27-12-14)30-6-7-33-20-10-16(2-4-19(20)30)35(31,32)29-21-28-5-8-34-21/h1-5,8-13H,6-7H2,(H,28,29)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 11.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231476
PNG
(US9346798, 223)
Show SMILES COc1cc(ccc1N1C(=O)COc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C19H14F3N3O5S2/c1-29-15-8-11(19(20,21)22)2-4-13(15)25-14-5-3-12(9-16(14)30-10-17(25)26)32(27,28)24-18-23-6-7-31-18/h2-9H,10H2,1H3,(H,23,24)
PDB

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UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231278
PNG
(US9346798, 25)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(c1)C1=CCOCC1
Show InChI InChI=1S/C22H19F3N4O4S2/c23-22(24,25)15-1-3-18(17(11-15)14-5-8-32-9-6-14)29-7-10-33-20-12-16(2-4-19(20)29)35(30,31)28-21-26-13-27-34-21/h1-5,11-13H,6-10H2,(H,26,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 12.3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231463
PNG
(US9346798, 210)
Show SMILES OCC(O)Cc1cc(Cl)ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H20ClN3O5S2/c21-14-1-3-17(13(9-14)10-15(26)12-25)24-6-7-29-19-11-16(2-4-18(19)24)31(27,28)23-20-22-5-8-30-20/h1-5,8-9,11,15,25-26H,6-7,10,12H2,(H,22,23)
PDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 12.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231462
PNG
(US9346798, 209)
Show SMILES OC[C@H](O)Cc1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C21H20F3N3O5S2/c22-21(23,24)14-1-3-17(13(9-14)10-15(29)12-28)27-6-7-32-19-11-16(2-4-18(19)27)34(30,31)26-20-25-5-8-33-20/h1-5,8-9,11,15,28-29H,6-7,10,12H2,(H,25,26)/t15-/m1/s1
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n/an/a 12.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231291
PNG
(US9346798, 38)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C1=CCNCC1
Show InChI InChI=1S/C23H21F3N4O3S2/c24-23(25,26)16-1-3-19(18(13-16)15-5-7-27-8-6-15)30-10-11-33-21-14-17(2-4-20(21)30)35(31,32)29-22-28-9-12-34-22/h1-5,9,12-14,27H,6-8,10-11H2,(H,28,29)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231404
PNG
(US9346798, 151)
Show SMILES COc1ccc(F)cc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H16FN3O4S2/c1-25-16-5-2-12(19)10-15(16)22-7-8-26-17-11-13(3-4-14(17)22)28(23,24)21-18-20-6-9-27-18/h2-6,9-11H,7-8H2,1H3,(H,20,21)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231297
PNG
(US9346798, 44)
Show SMILES CN1CCC(=CC1)c1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N4O3S2/c1-30-9-6-16(7-10-30)19-14-17(24(25,26)27)2-4-20(19)31-11-12-34-22-15-18(3-5-21(22)31)36(32,33)29-23-28-8-13-35-23/h2-6,8,13-15H,7,9-12H2,1H3,(H,28,29)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231300
PNG
(US9346798, 47)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ccncn2)c(Br)c1
Show InChI InChI=1S/C19H14BrF3N4O3S/c20-14-9-12(19(21,22)23)1-3-15(14)27-7-8-30-17-10-13(2-4-16(17)27)31(28,29)26-18-5-6-24-11-25-18/h1-6,9-11H,7-8H2,(H,24,25,26)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231312
PNG
(US9346798, 59)
Show SMILES O=S(=O)(Nc1nccs1)c1ccc2N(CCOc2c1)c1ccccc1N1CCNCC1
Show InChI InChI=1S/C21H23N5O3S2/c27-31(28,24-21-23-9-14-30-21)16-5-6-19-20(15-16)29-13-12-26(19)18-4-2-1-3-17(18)25-10-7-22-8-11-25/h1-6,9,14-15,22H,7-8,10-13H2,(H,23,24)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231302
PNG
(US9346798, 49)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C#N
Show InChI InChI=1S/C19H13F3N4O3S2/c20-19(21,22)13-1-3-15(12(9-13)11-23)26-6-7-29-17-10-14(2-4-16(17)26)31(27,28)25-18-24-5-8-30-18/h1-5,8-10H,6-7H2,(H,24,25)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231274
PNG
(US9346798, 21)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(c1)-c1cccnc1
Show InChI InChI=1S/C22H16F3N5O3S2/c23-22(24,25)15-3-5-18(17(10-15)14-2-1-7-26-12-14)30-8-9-33-20-11-16(4-6-19(20)30)35(31,32)29-21-27-13-28-34-21/h1-7,10-13H,8-9H2,(H,27,28,29)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231284
PNG
(US9346798, 31)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(c1)C#N
Show InChI InChI=1S/C18H12F3N5O3S2/c19-18(20,21)12-1-3-14(11(7-12)9-22)26-5-6-29-16-8-13(2-4-15(16)26)31(27,28)25-17-23-10-24-30-17/h1-4,7-8,10H,5-6H2,(H,23,24,25)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231403
PNG
(US9346798, 150)
Show SMILES COc1cc(F)ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H16FN3O4S2/c1-25-16-10-12(19)2-4-14(16)22-7-8-26-17-11-13(3-5-15(17)22)28(23,24)21-18-20-6-9-27-18/h2-6,9-11H,7-8H2,1H3,(H,20,21)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231461
PNG
(US9346798, 208)
Show SMILES OC[C@@H](O)Cc1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C21H20F3N3O5S2/c22-21(23,24)14-1-3-17(13(9-14)10-15(29)12-28)27-6-7-32-19-11-16(2-4-18(19)27)34(30,31)26-20-25-5-8-33-20/h1-5,8-9,11,15,28-29H,6-7,10,12H2,(H,25,26)/t15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231465
PNG
(US9346798, 212)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(c(Cl)cc23)S(=O)(=O)Nc2nccs2)c(c1)C#N
Show InChI InChI=1S/C19H12ClF3N4O3S2/c20-13-8-15-16(9-17(13)32(28,29)26-18-25-3-6-31-18)30-5-4-27(15)14-2-1-12(19(21,22)23)7-11(14)10-24/h1-3,6-9H,4-5H2,(H,25,26)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231306
PNG
(US9346798, 53)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)-c1ccncc1
Show InChI InChI=1S/C23H17F3N4O3S2/c24-23(25,26)16-1-3-19(18(13-16)15-5-7-27-8-6-15)30-10-11-33-21-14-17(2-4-20(21)30)35(31,32)29-22-28-9-12-34-22/h1-9,12-14H,10-11H2,(H,28,29)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231260
PNG
(US9346798, 7)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(c1)C1=CCNCC1
Show InChI InChI=1S/C22H20F3N5O3S2/c23-22(24,25)15-1-3-18(17(11-15)14-5-7-26-8-6-14)30-9-10-33-20-12-16(2-4-19(20)30)35(31,32)29-21-27-13-28-34-21/h1-5,11-13,26H,6-10H2,(H,27,28,29)
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n/an/a 23.7n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231318
PNG
(US9346798, 65)
Show SMILES [N-]=[N+]=Nc1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C1=CCNCC1
Show InChI InChI=1S/C22H21N7O3S2/c23-28-26-16-1-3-19(18(13-16)15-5-7-24-8-6-15)29-10-11-32-21-14-17(2-4-20(21)29)34(30,31)27-22-25-9-12-33-22/h1-5,9,12-14,24H,6-8,10-11H2,(H,25,27)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231318
PNG
(US9346798, 65)
Show SMILES [N-]=[N+]=Nc1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C1=CCNCC1
Show InChI InChI=1S/C22H21N7O3S2/c23-28-26-16-1-3-19(18(13-16)15-5-7-24-8-6-15)29-10-11-32-21-14-17(2-4-20(21)29)34(30,31)27-22-25-9-12-33-22/h1-5,9,12-14,24H,6-8,10-11H2,(H,25,27)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231460
PNG
(US9346798, 207)
Show SMILES OCC(O)Cc1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C21H20F3N3O5S2/c22-21(23,24)14-1-3-17(13(9-14)10-15(29)12-28)27-6-7-32-19-11-16(2-4-18(19)27)34(30,31)26-20-25-5-8-33-20/h1-5,8-9,11,15,28-29H,6-7,10,12H2,(H,25,26)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231340
PNG
(US9346798, 87)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2cccnn2)c(c1)C1=CCNCC1
Show InChI InChI=1S/C24H22F3N5O3S/c25-24(26,27)17-3-5-20(19(14-17)16-7-10-28-11-8-16)32-12-13-35-22-15-18(4-6-21(22)32)36(33,34)31-23-2-1-9-29-30-23/h1-7,9,14-15,28H,8,10-13H2,(H,30,31)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231316
PNG
(US9346798, 63)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2cscn2)c(c1)C1=CCNCC1
Show InChI InChI=1S/C23H21F3N4O3S2/c24-23(25,26)16-1-3-19(18(11-16)15-5-7-27-8-6-15)30-9-10-33-21-12-17(2-4-20(21)30)35(31,32)29-22-13-34-14-28-22/h1-5,11-14,27,29H,6-10H2
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231342
PNG
(US9346798, 89)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ccncn2)c(c1)C#N
Show InChI InChI=1S/C20H14F3N5O3S/c21-20(22,23)14-1-3-16(13(9-14)11-24)28-7-8-31-18-10-15(2-4-17(18)28)32(29,30)27-19-5-6-25-12-26-19/h1-6,9-10,12H,7-8H2,(H,25,26,27)
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231360
PNG
(US9346798, 107)
Show SMILES COc1cc(ccc1N1C[C@H](C)Oc2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N
Show InChI InChI=1S/C20H18N4O4S2/c1-13-12-24(16-5-3-14(11-21)9-18(16)27-2)17-6-4-15(10-19(17)28-13)30(25,26)23-20-22-7-8-29-20/h3-10,13H,12H2,1-2H3,(H,22,23)/t13-/m0/s1
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AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231301
PNG
(US9346798, 48)
Show SMILES COCCNc1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1ccncn1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N5O4S/c1-33-10-8-27-17-12-15(22(23,24)25)2-4-18(17)30-9-11-34-20-13-16(3-5-19(20)30)35(31,32)29-21-6-7-26-14-28-21/h2-7,12-14,27H,8-11H2,1H3,(H,26,28,29)
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n/an/a 28.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


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More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231276
PNG
(US9346798, 23)
Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(c1)-c1cncnc1
Show InChI InChI=1S/C21H15F3N6O3S2/c22-21(23,24)14-1-3-17(16(7-14)13-9-25-11-26-10-13)30-5-6-33-19-8-15(2-4-18(19)30)35(31,32)29-20-27-12-28-34-20/h1-4,7-12H,5-6H2,(H,27,28,29)
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UniChem
US Patent
n/an/a 29.8n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231289
PNG
(US9346798, 36)
Show SMILES O=S(=O)(Nc1ncns1)c1ccc2N(CCOc2c1)c1cccc2ccccc12
Show InChI InChI=1S/C20H16N4O3S2/c25-29(26,23-20-21-13-22-28-20)15-8-9-18-19(12-15)27-11-10-24(18)17-7-3-5-14-4-1-2-6-16(14)17/h1-9,12-13H,10-11H2,(H,21,22,23)
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UniChem
US Patent
n/an/a 31.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231459
PNG
(US9346798, 206)
Show SMILES OCc1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C19H16F3N3O4S2/c20-19(21,22)13-1-3-15(12(9-13)11-26)25-6-7-29-17-10-14(2-4-16(17)25)31(27,28)24-18-23-5-8-30-18/h1-5,8-10,26H,6-7,11H2,(H,23,24)
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UniChem
US Patent
n/an/a 31.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231364
PNG
(US9346798, 111)
Show SMILES COc1ncc(Cl)cc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C17H15ClN4O4S2/c1-25-16-14(8-11(18)10-20-16)22-5-6-26-15-9-12(2-3-13(15)22)28(23,24)21-17-19-4-7-27-17/h2-4,7-10H,5-6H2,1H3,(H,19,21)
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US Patent
n/an/a 33.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231469
PNG
(US9346798, 216)
Show SMILES Fc1c2OCCN(c2ccc1S(=O)(=O)Nc1nccs1)c1ccc(cc1C#N)C(F)(F)F
Show InChI InChI=1S/C19H12F4N4O3S2/c20-16-15(32(28,29)26-18-25-5-8-31-18)4-3-14-17(16)30-7-6-27(14)13-2-1-12(19(21,22)23)9-11(13)10-24/h1-5,8-9H,6-7H2,(H,25,26)
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UniChem
US Patent
n/an/a 34n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231305
PNG
(US9346798, 52)
Show SMILES Clc1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2nccs2)c(c1)C1=CCNCC1
Show InChI InChI=1S/C22H21ClN4O3S2/c23-16-1-3-19(18(13-16)15-5-7-24-8-6-15)27-10-11-30-21-14-17(2-4-20(21)27)32(28,29)26-22-25-9-12-31-22/h1-5,9,12-14,24H,6-8,10-11H2,(H,25,26)
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US Patent
n/an/a 35.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM231478
PNG
(US9346798, 226)
Show SMILES Cc1cc(ccc1N1CCOc2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N
Show InChI InChI=1S/C19H16N4O3S2/c1-13-10-14(12-20)2-4-16(13)23-7-8-26-18-11-15(3-5-17(18)23)28(24,25)22-19-21-6-9-27-19/h2-6,9-11H,7-8H2,1H3,(H,21,22)
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UniChem
US Patent
n/an/a 36.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...


Citation and Details
More data for this
Ligand-Target Pair
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