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Patent code US9346814

Compile Data Set for Download or QSAR

Found 250 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50009366
PNG
(CHEMBL3233842 | US9346814, Cmpd No 1, Example 1)
Show SMILES FC1(F)C[C@@H](C#N)N(C1)C(=O)CNC(=O)c1ccnc2ccccc12
Show InChI InChI=1S/C17H14F2N4O2/c18-17(19)7-11(8-20)23(10-17)15(24)9-22-16(25)13-5-6-21-14-4-2-1-3-12(13)14/h1-6,11H,7,9-10H2,(H,22,25)/t11-/m0/s1
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n/an/a 3.20n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50009360
PNG
(CHEMBL3233835 | US9346814, Cmpd No 23 Example 27)
Show SMILES Cc1cccc2nccc(C(=O)NCC(=O)N3CCC[C@H]3C#N)c12
Show InChI InChI=1S/C18H18N4O2/c1-12-4-2-6-15-17(12)14(7-8-20-15)18(24)21-11-16(23)22-9-3-5-13(22)10-19/h2,4,6-8,13H,3,5,9,11H2,1H3,(H,21,24)/t13-/m0/s1
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n/an/a 4.30n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50434163
PNG
(CHEMBL2385273 | US9346814, Cmpd No 12 Example 15)
Show SMILES Brc1ccc2c(ccnc2c1)C(=O)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H15BrN4O2/c18-11-3-4-13-14(5-6-20-15(13)8-11)17(24)21-10-16(23)22-7-1-2-12(22)9-19/h3-6,8,12H,1-2,7,10H2,(H,21,24)/t12-/m0/s1
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n/an/a 6.20n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM233322
PNG
(US9346814, Cmpd No 27 Example 32)
Show SMILES Cc1ccc2c(ccnc2c1)C(=O)NCC(=O)N1CCC[C@H]1[N+]#[C-]
Show InChI InChI=1S/C18H18N4O2/c1-12-5-6-13-14(7-8-20-15(13)10-12)18(24)21-11-17(23)22-9-3-4-16(22)19-2/h5-8,10,16H,3-4,9,11H2,1H3,(H,21,24)/t16-/m0/s1
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n/an/a 6.90n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50434164
PNG
(CHEMBL2385272 | US9346814, Cmpd No 13 Example 16)
Show SMILES Clc1ccc2c(ccnc2c1)C(=O)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H15ClN4O2/c18-11-3-4-13-14(5-6-20-15(13)8-11)17(24)21-10-16(23)22-7-1-2-12(22)9-19/h3-6,8,12H,1-2,7,10H2,(H,21,24)/t12-/m0/s1
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n/an/a 7.10n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50009331
PNG
(CHEMBL3233843 | US9346814, Cmpd No 24 Example 28)
Show SMILES COc1ccc2nccc(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)c2c1
Show InChI InChI=1S/C18H16F2N4O3/c1-27-12-2-3-15-14(6-12)13(4-5-22-15)17(26)23-9-16(25)24-10-18(19,20)7-11(24)8-21/h2-6,11H,7,9-10H2,1H3,(H,23,26)/t11-/m0/s1
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n/an/a 8.5n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50434165
PNG
(CHEMBL2385271 | US9346814, Cmpd No 11 Example 14)
Show SMILES COc1ccc2nccc(C(=O)NCC(=O)N3CCC[C@H]3C#N)c2c1
Show InChI InChI=1S/C18H18N4O3/c1-25-13-4-5-16-15(9-13)14(6-7-20-16)18(24)21-11-17(23)22-8-2-3-12(22)10-19/h4-7,9,12H,2-3,8,11H2,1H3,(H,21,24)/t12-/m0/s1
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n/an/a 9.20n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50434170
PNG
(CHEMBL2385299 | US9346814, Cmpd No 21 Example 25)
Show SMILES Clc1cccc2nccc(C(=O)NCC(=O)N3CCC[C@H]3C#N)c12
Show InChI InChI=1S/C17H15ClN4O2/c18-13-4-1-5-14-16(13)12(6-7-20-14)17(24)21-10-15(23)22-8-2-3-11(22)9-19/h1,4-7,11H,2-3,8,10H2,(H,21,24)/t11-/m0/s1
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n/an/a 9.90n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50434188
PNG
(CHEMBL2385281 | US9346814, Cmpd No 2 Example 3)
Show SMILES O=C(CNC(=O)c1ccnc2ccccc12)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H16N4O2/c18-10-12-4-3-9-21(12)16(22)11-20-17(23)14-7-8-19-15-6-2-1-5-13(14)15/h1-2,5-8,12H,3-4,9,11H2,(H,20,23)/t12-/m0/s1
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n/an/a 10.3n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50434166
PNG
(CHEMBL2385270 | US9346814, Cmpd No 6 Example 9)
Show SMILES Fc1ccc2nccc(C(=O)NCC(=O)N3CCC[C@H]3C#N)c2c1
Show InChI InChI=1S/C17H15FN4O2/c18-11-3-4-15-14(8-11)13(5-6-20-15)17(24)21-10-16(23)22-7-1-2-12(22)9-19/h3-6,8,12H,1-2,7,10H2,(H,21,24)/t12-/m0/s1
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n/an/a 10.3n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50434169
PNG
(CHEMBL2385300 | US9346814, Cmpd No 22 Example 26)
Show SMILES Brc1cccc2nccc(C(=O)NCC(=O)N3CCC[C@H]3C#N)c12
Show InChI InChI=1S/C17H15BrN4O2/c18-13-4-1-5-14-16(13)12(6-7-20-14)17(24)21-10-15(23)22-8-2-3-11(22)9-19/h1,4-7,11H,2-3,8,10H2,(H,21,24)/t11-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50434167
PNG
(CHEMBL2385302 | US9346814, Cmpd No 8 Example 11)
Show SMILES FC(F)(F)Oc1ccc2nccc(C(=O)NCC(=O)N3CCC[C@H]3C#N)c2c1
Show InChI InChI=1S/C18H15F3N4O3/c19-18(20,21)28-12-3-4-15-14(8-12)13(5-6-23-15)17(27)24-10-16(26)25-7-1-2-11(25)9-22/h3-6,8,11H,1-2,7,10H2,(H,24,27)/t11-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50434168
PNG
(CHEMBL2385301 | US9346814, Cmpd No 7 Example 10)
Show SMILES Clc1ccc2nccc(C(=O)NCC(=O)N3CCC[C@H]3C#N)c2c1
Show InChI InChI=1S/C17H15ClN4O2/c18-11-3-4-15-14(8-11)13(5-6-20-15)17(24)21-10-16(23)22-7-1-2-12(22)9-19/h3-6,8,12H,1-2,7,10H2,(H,21,24)/t12-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50009358
PNG
(CHEMBL3233833 | US9346814, Cmpd No 33 Example 38)
Show SMILES O=C(CNC(=O)c1ccnc2cnccc12)N1CCC[C@H]1C#N
Show InChI InChI=1S/C16H15N5O2/c17-8-11-2-1-7-21(11)15(22)10-20-16(23)13-4-6-19-14-9-18-5-3-12(13)14/h3-6,9,11H,1-2,7,10H2,(H,20,23)/t11-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM233323
PNG
(US9346814, Cmpd No 29 Example 34)
Show SMILES O=C(CNC(=O)C1=CC=NC2=NC=CC12)N1CCC[C@H]1C#N
Show InChI InChI=1S/C15H15N5O2/c16-8-10-2-1-7-20(10)13(21)9-19-15(22)12-4-6-18-14-11(12)3-5-17-14/h3-6,10-11H,1-2,7,9H2,(H,19,22)/t10-,11?/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50009361
PNG
(CHEMBL3233837 | US9346814, Cmpd No 25 Example 30)
Show SMILES O=C(CNC(=O)c1ccnc2cc(Nc3ccccc3)ccc12)N1CCC[C@H]1C#N
Show InChI InChI=1S/C23H21N5O2/c24-14-18-7-4-12-28(18)22(29)15-26-23(30)20-10-11-25-21-13-17(8-9-19(20)21)27-16-5-2-1-3-6-16/h1-3,5-6,8-11,13,18,27H,4,7,12,15H2,(H,26,30)/t18-/m0/s1
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n/an/a 59n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50009334
PNG
(CHEMBL3233554 | US9346814, Cmpd No 4 Example 6)
Show SMILES O=C(CNC(=O)c1ccncc1)N1CCC[C@H]1C#N
Show InChI InChI=1S/C13H14N4O2/c14-8-11-2-1-7-17(11)12(18)9-16-13(19)10-3-5-15-6-4-10/h3-6,11H,1-2,7,9H2,(H,16,19)/t11-/m0/s1
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n/an/a 63n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50009332
PNG
(CHEMBL3233836 | US9346814, Cmpd No 26 Example 31)
Show SMILES O=C(CNC(=O)c1ccnc2cc(ccc12)-c1ccccc1)N1CCC[C@H]1C#N
Show InChI InChI=1S/C23H20N4O2/c24-14-18-7-4-12-27(18)22(28)15-26-23(29)20-10-11-25-21-13-17(8-9-19(20)21)16-5-2-1-3-6-16/h1-3,5-6,8-11,13,18H,4,7,12,15H2,(H,26,29)/t18-/m0/s1
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n/an/a 64n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50009362
PNG
(CHEMBL3233838 | US9346814, Cmpd No 25 Example 29)
Show SMILES O=C(CNC(=O)c1ccnc2cccc(-c3ccccc3)c12)N1CCC[C@H]1C#N
Show InChI InChI=1S/C23H20N4O2/c24-14-17-8-5-13-27(17)21(28)15-26-23(29)19-11-12-25-20-10-4-9-18(22(19)20)16-6-2-1-3-7-16/h1-4,6-7,9-12,17H,5,8,13,15H2,(H,26,29)/t17-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50382283
PNG
(CHEMBL2022530 | US9346814, Ref. Cmpd No 1 (Example...)
Show SMILES FC1(F)C[C@@H](C#N)N(C1)C(=O)CNC(=O)c1cccc2ccccc12
Show InChI InChI=1S/C18H15F2N3O2/c19-18(20)8-13(9-21)23(11-18)16(24)10-22-17(25)15-7-3-5-12-4-1-2-6-14(12)15/h1-7,13H,8,10-11H2,(H,22,25)/t13-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Endopeptidase prolyl oligopeptidase (PREP)


(Homo sapiens (Human))
BDBM233327
PNG
(US9346814, Ref Cmpd No 8)
Show SMILES O=C(CNC(=O)c1cncc2ccccc12)N1CCCC1C#N
Show InChI InChI=1S/C17H16N4O2/c18-8-13-5-3-7-21(13)16(22)11-20-17(23)15-10-19-9-12-4-1-2-6-14(12)15/h1-2,4,6,9-10,13H,3,5,7,11H2,(H,20,23)
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n/an/a 130n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50434171
PNG
(CHEMBL2385298 | US9346814, Cmpd No 38 Example 43)
Show SMILES Oc1cnc2ccccc2c1C(=O)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H16N4O3/c18-8-11-4-3-7-21(11)15(23)10-20-17(24)16-12-5-1-2-6-13(12)19-9-14(16)22/h1-2,5-6,9,11,22H,3-4,7,10H2,(H,20,24)/t11-/m0/s1
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n/an/a 160n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50434162
PNG
(CHEMBL2385274 | US9346814, Cmpd No 9 Example 12)
Show SMILES Clc1cccc2c(ccnc12)C(=O)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H15ClN4O2/c18-14-5-1-4-12-13(6-7-20-16(12)14)17(24)21-10-15(23)22-8-2-3-11(22)9-19/h1,4-7,11H,2-3,8,10H2,(H,21,24)/t11-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


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More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50009356
PNG
(CHEMBL3233574 | US9346814, Cmpd No 28 Example 33)
Show SMILES COc1ccc(cc1)-c1nc2c(ccnc2[nH]1)C(=O)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C21H20N6O3/c1-30-15-6-4-13(5-7-15)19-25-18-16(8-9-23-20(18)26-19)21(29)24-12-17(28)27-10-2-3-14(27)11-22/h4-9,14H,2-3,10,12H2,1H3,(H,24,29)(H,23,25,26)/t14-/m0/s1
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n/an/a<200n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50009340
PNG
(CHEMBL3233559 | US9346814, Cmpd No 15 Example 19)
Show SMILES COc1ccc(cc1OC)-c1cc(ccn1)C(=O)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C21H22N4O4/c1-28-18-6-5-14(11-19(18)29-2)17-10-15(7-8-23-17)21(27)24-13-20(26)25-9-3-4-16(25)12-22/h5-8,10-11,16H,3-4,9,13H2,1-2H3,(H,24,27)/t16-/m0/s1
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n/an/a 220n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50009341
PNG
(CHEMBL3233560 | US9346814, Cmpd No 16 Example 20)
Show SMILES O=C(CNC(=O)c1ccnc(c1)-c1ccc(cc1)C#N)N1CCC[C@H]1C#N
Show InChI InChI=1S/C20H17N5O2/c21-11-14-3-5-15(6-4-14)18-10-16(7-8-23-18)20(27)24-13-19(26)25-9-1-2-17(25)12-22/h3-8,10,17H,1-2,9,13H2,(H,24,27)/t17-/m0/s1
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n/an/a 270n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50009339
PNG
(CHEMBL3233558 | US9346814, Cmpd No 14 Example 18)
Show SMILES O=C(CNC(=O)c1ccnc(c1)-c1ccccc1)N1CCC[C@H]1C#N
Show InChI InChI=1S/C19H18N4O2/c20-12-16-7-4-10-23(16)18(24)13-22-19(25)15-8-9-21-17(11-15)14-5-2-1-3-6-14/h1-3,5-6,8-9,11,16H,4,7,10,13H2,(H,22,25)/t16-/m0/s1
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n/an/a 290n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Endopeptidase prolyl oligopeptidase (PREP)


(Homo sapiens (Human))
BDBM50434162
PNG
(CHEMBL2385274 | US9346814, Cmpd No 9 Example 12)
Show SMILES Clc1cccc2c(ccnc12)C(=O)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H15ClN4O2/c18-14-5-1-4-12-13(6-7-20-16(12)14)17(24)21-10-15(23)22-8-2-3-11(22)9-19/h1,4-7,11H,2-3,8,10H2,(H,21,24)/t11-/m0/s1
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n/an/a 350n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Endopeptidase prolyl oligopeptidase (PREP)


(Homo sapiens (Human))
BDBM50434161
PNG
(CHEMBL2385275 | US9346814, Cmpd No 10 Example 13)
Show SMILES Brc1cccc2c(ccnc12)C(=O)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H15BrN4O2/c18-14-5-1-4-12-13(6-7-20-16(12)14)17(24)21-10-15(23)22-8-2-3-11(22)9-19/h1,4-7,11H,2-3,8,10H2,(H,21,24)/t11-/m0/s1
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n/an/a 360n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50434161
PNG
(CHEMBL2385275 | US9346814, Cmpd No 10 Example 13)
Show SMILES Brc1cccc2c(ccnc12)C(=O)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H15BrN4O2/c18-14-5-1-4-12-13(6-7-20-16(12)14)17(24)21-10-15(23)22-8-2-3-11(22)9-19/h1,4-7,11H,2-3,8,10H2,(H,21,24)/t11-/m0/s1
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n/an/a 370n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50434159
PNG
(CHEMBL2385277 | US9346814, Ref Cmpd No 7 (example ...)
Show SMILES O=C(CNC(=O)c1cccc2ncccc12)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H16N4O2/c18-10-12-4-3-9-21(12)16(22)11-20-17(23)14-5-1-7-15-13(14)6-2-8-19-15/h1-2,5-8,12H,3-4,9,11H2,(H,20,23)/t12-/m0/s1
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n/an/a 420n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Endopeptidase prolyl oligopeptidase (PREP)


(Homo sapiens (Human))
BDBM233322
PNG
(US9346814, Cmpd No 27 Example 32)
Show SMILES Cc1ccc2c(ccnc2c1)C(=O)NCC(=O)N1CCC[C@H]1[N+]#[C-]
Show InChI InChI=1S/C18H18N4O2/c1-12-5-6-13-14(7-8-20-15(13)10-12)18(24)21-11-17(23)22-9-3-4-16(22)19-2/h5-8,10,16H,3-4,9,11H2,1H3,(H,21,24)/t16-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM233327
PNG
(US9346814, Ref Cmpd No 8)
Show SMILES O=C(CNC(=O)c1cncc2ccccc12)N1CCCC1C#N
Show InChI InChI=1S/C17H16N4O2/c18-8-13-5-3-7-21(13)16(22)11-20-17(23)15-10-19-9-12-4-1-2-6-14(12)15/h1-2,4,6,9-10,13H,3,5,7,11H2,(H,20,23)
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n/an/a 610n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Endopeptidase prolyl oligopeptidase (PREP)


(Homo sapiens (Human))
BDBM50434166
PNG
(CHEMBL2385270 | US9346814, Cmpd No 6 Example 9)
Show SMILES Fc1ccc2nccc(C(=O)NCC(=O)N3CCC[C@H]3C#N)c2c1
Show InChI InChI=1S/C17H15FN4O2/c18-11-3-4-15-14(8-11)13(5-6-20-15)17(24)21-10-16(23)22-7-1-2-12(22)9-19/h3-6,8,12H,1-2,7,10H2,(H,21,24)/t12-/m0/s1
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n/an/a 610n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Endopeptidase prolyl oligopeptidase (PREP)


(Homo sapiens (Human))
BDBM50434176
PNG
(CHEMBL2385293 | US9346814, Cmpd No 3 Example 4)
Show SMILES Cc1cc(C(=O)NCC(=O)N2CCC[C@H]2C#N)c2ccccc2n1
Show InChI InChI=1S/C18H18N4O2/c1-12-9-15(14-6-2-3-7-16(14)21-12)18(24)20-11-17(23)22-8-4-5-13(22)10-19/h2-3,6-7,9,13H,4-5,8,11H2,1H3,(H,20,24)/t13-/m0/s1
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n/an/a 640n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM233320
PNG
(US9346814, Ref. Cmpd No 2)
Show SMILES O=C(CNC(=O)c1cccc2ccccc12)N1CCCC1C#N
Show InChI InChI=1S/C18H17N3O2/c19-11-14-7-4-10-21(14)17(22)12-20-18(23)16-9-3-6-13-5-1-2-8-15(13)16/h1-3,5-6,8-9,14H,4,7,10,12H2,(H,20,23)
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n/an/a 670n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50434176
PNG
(CHEMBL2385293 | US9346814, Cmpd No 3 Example 4)
Show SMILES Cc1cc(C(=O)NCC(=O)N2CCC[C@H]2C#N)c2ccccc2n1
Show InChI InChI=1S/C18H18N4O2/c1-12-9-15(14-6-2-3-7-16(14)21-12)18(24)20-11-17(23)22-8-4-5-13(22)10-19/h2-3,6-7,9,13H,4-5,8,11H2,1H3,(H,20,24)/t13-/m0/s1
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n/an/a 670n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Endopeptidase prolyl oligopeptidase (PREP)


(Homo sapiens (Human))
BDBM50434167
PNG
(CHEMBL2385302 | US9346814, Cmpd No 8 Example 11)
Show SMILES FC(F)(F)Oc1ccc2nccc(C(=O)NCC(=O)N3CCC[C@H]3C#N)c2c1
Show InChI InChI=1S/C18H15F3N4O3/c19-18(20,21)28-12-3-4-15-14(8-12)13(5-6-23-15)17(27)24-10-16(26)25-7-1-2-11(25)9-22/h3-6,8,11H,1-2,7,10H2,(H,24,27)/t11-/m0/s1
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n/an/a 710n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50009343
PNG
(CHEMBL3233562 | US9346814, Cmpd No 20 Example 24)
Show SMILES O=C(CNC(=O)C1CCNCC1)N1CCC[C@H]1C#N
Show InChI InChI=1S/C13H20N4O2/c14-8-11-2-1-7-17(11)12(18)9-16-13(19)10-3-5-15-6-4-10/h10-11,15H,1-7,9H2,(H,16,19)/t11-/m0/s1
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n/an/a 750n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Endopeptidase prolyl oligopeptidase (PREP)


(Homo sapiens (Human))
BDBM50434168
PNG
(CHEMBL2385301 | US9346814, Cmpd No 7 Example 10)
Show SMILES Clc1ccc2nccc(C(=O)NCC(=O)N3CCC[C@H]3C#N)c2c1
Show InChI InChI=1S/C17H15ClN4O2/c18-11-3-4-15-14(8-11)13(5-6-20-15)17(24)21-10-16(23)22-7-1-2-12(22)9-19/h3-6,8,12H,1-2,7,10H2,(H,21,24)/t12-/m0/s1
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n/an/a 840n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Endopeptidase prolyl oligopeptidase (PREP)


(Homo sapiens (Human))
BDBM50434188
PNG
(CHEMBL2385281 | US9346814, Cmpd No 2 Example 3)
Show SMILES O=C(CNC(=O)c1ccnc2ccccc12)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H16N4O2/c18-10-12-4-3-9-21(12)16(22)11-20-17(23)14-7-8-19-15-6-2-1-5-13(14)15/h1-2,5-8,12H,3-4,9,11H2,(H,20,23)/t12-/m0/s1
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n/an/a 860n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50434188
PNG
(CHEMBL2385281 | US9346814, Cmpd No 2 Example 3)
Show SMILES O=C(CNC(=O)c1ccnc2ccccc12)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H16N4O2/c18-10-12-4-3-9-21(12)16(22)11-20-17(23)14-7-8-19-15-6-2-1-5-13(14)15/h1-2,5-8,12H,3-4,9,11H2,(H,20,23)/t12-/m0/s1
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n/an/a 860n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Endopeptidase prolyl oligopeptidase (PREP)


(Homo sapiens (Human))
BDBM50434163
PNG
(CHEMBL2385273 | US9346814, Cmpd No 12 Example 15)
Show SMILES Brc1ccc2c(ccnc2c1)C(=O)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H15BrN4O2/c18-11-3-4-13-14(5-6-20-15(13)8-11)17(24)21-10-16(23)22-7-1-2-12(22)9-19/h3-6,8,12H,1-2,7,10H2,(H,21,24)/t12-/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50009345
PNG
(CHEMBL3233564 | US9346814, Cmpd No 17 Example 21)
Show SMILES Cn1cncc1C(=O)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C12H15N5O2/c1-16-8-14-6-10(16)12(19)15-7-11(18)17-4-2-3-9(17)5-13/h6,8-9H,2-4,7H2,1H3,(H,15,19)/t9-/m0/s1
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n/an/a 1.37E+3n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Endopeptidase prolyl oligopeptidase (PREP)


(Homo sapiens (Human))
BDBM50434164
PNG
(CHEMBL2385272 | US9346814, Cmpd No 13 Example 16)
Show SMILES Clc1ccc2c(ccnc2c1)C(=O)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H15ClN4O2/c18-11-3-4-13-14(5-6-20-15(13)8-11)17(24)21-10-16(23)22-7-1-2-12(22)9-19/h3-6,8,12H,1-2,7,10H2,(H,21,24)/t12-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Endopeptidase prolyl oligopeptidase (PREP)


(Homo sapiens (Human))
BDBM50009366
PNG
(CHEMBL3233842 | US9346814, Cmpd No 1, Example 1)
Show SMILES FC1(F)C[C@@H](C#N)N(C1)C(=O)CNC(=O)c1ccnc2ccccc12
Show InChI InChI=1S/C17H14F2N4O2/c18-17(19)7-11(8-20)23(10-17)15(24)9-22-16(25)13-5-6-21-14-4-2-1-3-12(13)14/h1-6,11H,7,9-10H2,(H,22,25)/t11-/m0/s1
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n/an/a>1.80E+3n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Endopeptidase prolyl oligopeptidase (PREP)


(Homo sapiens (Human))
BDBM50009342
PNG
(CHEMBL3233561 | US9346814, Cmpd No 34 Example 39)
Show SMILES O=C(Cc1ccncc1)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C14H16N4O2/c15-9-12-2-1-7-18(12)14(20)10-17-13(19)8-11-3-5-16-6-4-11/h3-6,12H,1-2,7-8,10H2,(H,17,19)/t12-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Endopeptidase prolyl oligopeptidase (PREP)


(Homo sapiens (Human))
BDBM50009361
PNG
(CHEMBL3233837 | US9346814, Cmpd No 25 Example 30)
Show SMILES O=C(CNC(=O)c1ccnc2cc(Nc3ccccc3)ccc12)N1CCC[C@H]1C#N
Show InChI InChI=1S/C23H21N5O2/c24-14-18-7-4-12-28(18)22(29)15-26-23(30)20-10-11-25-21-13-17(8-9-19(20)21)27-16-5-2-1-3-6-16/h1-3,5-6,8-11,13,18,27H,4,7,12,15H2,(H,26,30)/t18-/m0/s1
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n/an/a 2.03E+3n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50434189
PNG
(CHEMBL2385280 | US9346814, Ref. Cmpd No 6 (Example...)
Show SMILES O=C(CNC(=O)c1cccc2cccnc12)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H16N4O2/c18-10-13-6-3-9-21(13)15(22)11-20-17(23)14-7-1-4-12-5-2-8-19-16(12)14/h1-2,4-5,7-8,13H,3,6,9,11H2,(H,20,23)/t13-/m0/s1
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n/an/a 2.17E+3n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM233328
PNG
(US9346814, Ref Cmpd No 9)
Show SMILES O=C(CNC(=O)c1ccnc2ccccc12)N1CCCC1C#N
Show InChI InChI=1S/C17H16N4O2/c18-10-12-4-3-9-21(12)16(22)11-20-17(23)14-7-8-19-15-6-2-1-5-13(14)15/h1-2,5-8,12H,3-4,9,11H2,(H,20,23)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Universiteit Antwerp; Fox Chase Cancer Center

US Patent


Assay Description
Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%