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Patent code US9346815

Compile Data Set for Download or QSAR

Found 934 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232618
PNG
(US9346815, 164)
Show SMILES CN1CCN(CCCN2CCC(CC2)n2cc(NC(=O)c3c(N)nn4cccnc34)c(n2)-c2cc(Cl)ccc2OC(F)F)C1=O
Show InChI InChI=1S/C29H33ClF2N10O3/c1-38-14-15-40(29(38)44)10-3-9-39-12-6-19(7-13-39)42-17-21(24(36-42)20-16-18(30)4-5-22(20)45-28(31)32)35-27(43)23-25(33)37-41-11-2-8-34-26(23)41/h2,4-5,8,11,16-17,19,28H,3,6-7,9-10,12-15H2,1H3,(H2,33,37)(H,35,43)
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0.0600n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232751
PNG
(US9346815, 297)
Show SMILES N[C@H]1C[C@H](C1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C21H19ClF2N8O2/c22-10-2-3-15(34-21(23)24)13(6-10)17-14(9-32(29-17)12-7-11(25)8-12)28-20(33)16-18(26)30-31-5-1-4-27-19(16)31/h1-6,9,11-12,21H,7-8,25H2,(H2,26,30)(H,28,33)/t11-,12+
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0.0700n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232631
PNG
(US9346815, 177)
Show SMILES CS(=O)(=O)CCCN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C26H29ClF2N8O4S/c1-42(39,40)13-3-9-35-11-6-17(7-12-35)37-15-19(22(33-37)18-14-16(27)4-5-20(18)41-26(28)29)32-25(38)21-23(30)34-36-10-2-8-31-24(21)36/h2,4-5,8,10,14-15,17,26H,3,6-7,9,11-13H2,1H3,(H2,30,34)(H,32,38)
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0.0900n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232628
PNG
(US9346815, 174)
Show SMILES CC(C)CN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C26H29ClF2N8O2/c1-15(2)13-35-10-6-17(7-11-35)37-14-19(22(33-37)18-12-16(27)4-5-20(18)39-26(28)29)32-25(38)21-23(30)34-36-9-3-8-31-24(21)36/h3-5,8-9,12,14-15,17,26H,6-7,10-11,13H2,1-2H3,(H2,30,34)(H,32,38)
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Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232602
PNG
(US9346815, 148)
Show SMILES CN(C)C(=O)CCCN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C28H32ClF2N9O3/c1-37(2)22(41)5-3-11-38-13-8-18(9-14-38)40-16-20(24(35-40)19-15-17(29)6-7-21(19)43-28(30)31)34-27(42)23-25(32)36-39-12-4-10-33-26(23)39/h4,6-7,10,12,15-16,18,28H,3,5,8-9,11,13-14H2,1-2H3,(H2,32,36)(H,34,42)
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232664
PNG
(US9346815, 210)
Show SMILES CCCCN(C)CC#Cc1nc(c(NC(=O)c2cnn3cccnc23)s1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C25H23ClF2N6O2S/c1-3-4-11-33(2)12-5-7-20-31-21(17-14-16(26)8-9-19(17)36-25(27)28)24(37-20)32-23(35)18-15-30-34-13-6-10-29-22(18)34/h6,8-10,13-15,25H,3-4,11-12H2,1-2H3,(H,32,35)
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232720
PNG
(US9346815, 266)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(CO)CC2)nc1-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C25H25ClF2N8O4/c26-15-2-3-18(40-25(27)28)16(10-15)21-17(31-24(39)20-22(29)33-36-7-1-6-30-23(20)36)11-35(32-21)12-19(38)34-8-4-14(13-37)5-9-34/h1-3,6-7,10-11,14,25,37H,4-5,8-9,12-13H2,(H2,29,33)(H,31,39)
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232744
PNG
(US9346815, 290)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCOCC2)nc1-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C23H21ClF2N8O4/c24-13-2-3-16(38-23(25)26)14(10-13)19-15(11-33(30-19)12-17(35)32-6-8-37-9-7-32)29-22(36)18-20(27)31-34-5-1-4-28-21(18)34/h1-5,10-11,23H,6-9,12H2,(H2,27,31)(H,29,36)
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0.110n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232736
PNG
(US9346815, 282)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(F)(F)C2)nc1-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C23H19ClF4N8O3/c24-12-2-3-15(39-22(25)26)13(8-12)18-14(9-35(32-18)10-16(37)34-7-4-23(27,28)11-34)31-21(38)17-19(29)33-36-6-1-5-30-20(17)36/h1-3,5-6,8-9,22H,4,7,10-11H2,(H2,29,33)(H,31,38)
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0.120n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232630
PNG
(US9346815, 176)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCN(CCCO)CC1
Show InChI InChI=1S/C25H27ClF2N8O3/c26-15-3-4-19(39-25(27)28)17(13-15)21-18(14-36(32-21)16-5-10-34(11-6-16)8-2-12-37)31-24(38)20-22(29)33-35-9-1-7-30-23(20)35/h1,3-4,7,9,13-14,16,25,37H,2,5-6,8,10-12H2,(H2,29,33)(H,31,38)
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Genentech, Inc.

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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232629
PNG
(US9346815, 175)
Show SMILES CCOC(=O)CCCN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C28H31ClF2N8O4/c1-2-42-22(40)5-3-11-37-13-8-18(9-14-37)39-16-20(24(35-39)19-15-17(29)6-7-21(19)43-28(30)31)34-27(41)23-25(32)36-38-12-4-10-33-26(23)38/h4,6-7,10,12,15-16,18,28H,2-3,5,8-9,11,13-14H2,1H3,(H2,32,36)(H,34,41)
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0.130n/an/an/an/an/an/an/an/a



Genentech, Inc.

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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232511
PNG
(US9346815, 57)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2C[C@@H]3CN(CC4CC4)C[C@@H]3C2)nc1-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C29H30ClF2N9O3/c30-19-4-5-22(44-29(31)32)20(8-19)25-21(35-28(43)24-26(33)37-41-7-1-6-34-27(24)41)14-40(36-25)15-23(42)39-12-17-10-38(9-16-2-3-16)11-18(17)13-39/h1,4-8,14,16-18,29H,2-3,9-13,15H2,(H2,33,37)(H,35,43)/t17-,18+
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0.130n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232600
PNG
(US9346815, 146)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCN(CCCN2CCCC2=O)CC1
Show InChI InChI=1S/C29H32ClF2N9O3/c30-18-5-6-22(44-29(31)32)20(16-18)25-21(35-28(43)24-26(33)37-40-13-2-9-34-27(24)40)17-41(36-25)19-7-14-38(15-8-19)10-3-12-39-11-1-4-23(39)42/h2,5-6,9,13,16-17,19,29H,1,3-4,7-8,10-12,14-15H2,(H2,33,37)(H,35,43)
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0.130n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232725
PNG
(US9346815, 271)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CC[C@@H](O)C2)nc1-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C23H21ClF2N8O4/c24-12-2-3-16(38-23(25)26)14(8-12)19-15(10-33(30-19)11-17(36)32-7-4-13(35)9-32)29-22(37)18-20(27)31-34-6-1-5-28-21(18)34/h1-3,5-6,8,10,13,23,35H,4,7,9,11H2,(H2,27,31)(H,29,37)/t13-/m1/s1
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0.130n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232627
PNG
(US9346815, 173)
Show SMILES CC(=O)N1CCC(CN2CCC(CC2)n2cc(NC(=O)c3c(N)nn4cccnc34)c(n2)-c2cc(Cl)ccc2OC(F)F)CC1
Show InChI InChI=1S/C30H34ClF2N9O3/c1-18(43)40-13-5-19(6-14-40)16-39-11-7-21(8-12-39)42-17-23(26(37-42)22-15-20(31)3-4-24(22)45-30(32)33)36-29(44)25-27(34)38-41-10-2-9-35-28(25)41/h2-4,9-10,15,17,19,21,30H,5-8,11-14,16H2,1H3,(H2,34,38)(H,36,44)
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0.130n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232615
PNG
(US9346815, 161)
Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCN(CCCN2CCS(=O)(=O)CC2)CC1
Show InChI InChI=1S/C29H33ClF2N8O4S/c30-20-3-4-25(44-29(31)32)22(17-20)26-24(35-28(41)23-18-34-39-10-1-7-33-27(23)39)19-40(36-26)21-5-11-37(12-6-21)8-2-9-38-13-15-45(42,43)16-14-38/h1,3-4,7,10,17-19,21,29H,2,5-6,8-9,11-16H2,(H,35,41)
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0.130n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232601
PNG
(US9346815, 147)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCN(CCCC(=O)N2CCOCC2)CC1
Show InChI InChI=1S/C30H34ClF2N9O4/c31-19-4-5-23(46-30(32)33)21(17-19)26-22(36-29(44)25-27(34)38-41-10-2-8-35-28(25)41)18-42(37-26)20-6-11-39(12-7-20)9-1-3-24(43)40-13-15-45-16-14-40/h2,4-5,8,10,17-18,20,30H,1,3,6-7,9,11-16H2,(H2,34,38)(H,36,44)
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Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232626
PNG
(US9346815, 172)
Show SMILES CN1CCCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C24H25ClF2N8O2/c1-33-9-2-4-15(7-11-33)35-13-17(20(31-35)16-12-14(25)5-6-18(16)37-24(26)27)30-23(36)19-21(28)32-34-10-3-8-29-22(19)34/h3,5-6,8,10,12-13,15,24H,2,4,7,9,11H2,1H3,(H2,28,32)(H,30,36)
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0.150n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232909
PNG
(US9346815, 455)
Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(Cc2cn(nn2)C2CCN(CC2)C2CCOC2)cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C29H29ClF2N10O3/c30-18-2-3-25(45-29(31)32)22(12-18)26-24(35-28(43)23-13-34-41-8-1-7-33-27(23)41)16-40(37-26)14-19-15-42(38-36-19)20-4-9-39(10-5-20)21-6-11-44-17-21/h1-3,7-8,12-13,15-16,20-21,29H,4-6,9-11,14,17H2,(H,35,43)
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0.150n/an/an/an/an/an/an/an/a



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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM232738
PNG
(US9346815, 284)
Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(CC(=O)N2CCC=CC2)cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C24H20ClF2N7O3/c25-15-5-6-19(37-24(26)27)16(11-15)21-18(13-33(31-21)14-20(35)32-8-2-1-3-9-32)30-23(36)17-12-29-34-10-4-7-28-22(17)34/h1-2,4-7,10-13,24H,3,8-9,14H2,(H,30,36)
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Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232619
PNG
(US9346815, 165)
Show SMILES NC(=O)CCN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C25H26ClF2N9O3/c26-14-2-3-18(40-25(27)28)16(12-14)21-17(32-24(39)20-22(30)34-36-8-1-7-31-23(20)36)13-37(33-21)15-4-9-35(10-5-15)11-6-19(29)38/h1-3,7-8,12-13,15,25H,4-6,9-11H2,(H2,29,38)(H2,30,34)(H,32,39)
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Genentech, Inc.

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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232706
PNG
(US9346815, 252)
Show SMILES CN1C[C@H]2C[C@@H]1CN2C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C25H24ClF2N9O3/c1-34-9-15-8-14(34)10-36(15)19(38)12-35-11-17(21(32-35)16-7-13(26)3-4-18(16)40-25(27)28)31-24(39)20-22(29)33-37-6-2-5-30-23(20)37/h2-7,11,14-15,25H,8-10,12H2,1H3,(H2,29,33)(H,31,39)/t14-,15-/m1/s1
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Genentech, Inc.

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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM232664
PNG
(US9346815, 210)
Show SMILES CCCCN(C)CC#Cc1nc(c(NC(=O)c2cnn3cccnc23)s1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C25H23ClF2N6O2S/c1-3-4-11-33(2)12-5-7-20-31-21(17-14-16(26)8-9-19(17)36-25(27)28)24(37-20)32-23(35)18-15-30-34-13-6-10-29-22(18)34/h6,8-10,13-15,25H,3-4,11-12H2,1-2H3,(H,32,35)
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0.160n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232599
PNG
(US9346815, 145)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCN(CCCNC(=O)c2ccccc2)CC1
Show InChI InChI=1S/C32H32ClF2N9O3/c33-21-8-9-25(47-32(34)35)23(18-21)27-24(39-31(46)26-28(36)41-43-15-5-12-37-29(26)43)19-44(40-27)22-10-16-42(17-11-22)14-4-13-38-30(45)20-6-2-1-3-7-20/h1-3,5-9,12,15,18-19,22,32H,4,10-11,13-14,16-17H2,(H2,36,41)(H,38,45)(H,39,46)
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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232598
PNG
(US9346815, 144)
Show SMILES CC(=O)N1CCC(CC1)N1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C29H32ClF2N9O3/c1-17(42)38-11-5-19(6-12-38)39-13-7-20(8-14-39)41-16-22(25(36-41)21-15-18(30)3-4-23(21)44-29(31)32)35-28(43)24-26(33)37-40-10-2-9-34-27(24)40/h2-4,9-10,15-16,19-20,29H,5-8,11-14H2,1H3,(H2,33,37)(H,35,43)
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Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232604
PNG
(US9346815, 150)
Show SMILES CC(=O)NCCCN1CCC(CC1)n1cc(NC(=O)C(\C(N)=N)=C2\NC=CC=N2)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C27H32ClF2N9O3/c1-16(40)33-10-3-11-38-12-6-18(7-13-38)39-15-20(36-26(41)22(24(31)32)25-34-8-2-9-35-25)23(37-39)19-14-17(28)4-5-21(19)42-27(29)30/h2,4-5,8-9,14-15,18,27,34H,3,6-7,10-13H2,1H3,(H3,31,32)(H,33,40)(H,36,41)/b25-22-
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Genentech, Inc.

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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232576
PNG
(US9346815, 122)
Show SMILES CN(Cc1cccc(Br)c1)C1CCN(CC1)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C32H30BrClF2N8O3/c1-41(17-20-4-2-5-21(33)14-20)23-8-12-42(13-9-23)28(45)19-43-18-26(39-31(46)25-16-38-44-11-3-10-37-30(25)44)29(40-43)24-15-22(34)6-7-27(24)47-32(35)36/h2-7,10-11,14-16,18,23,32H,8-9,12-13,17,19H2,1H3,(H,39,46)
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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM232736
PNG
(US9346815, 282)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CCC(F)(F)C2)nc1-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C23H19ClF4N8O3/c24-12-2-3-15(39-22(25)26)13(8-12)18-14(9-35(32-18)10-16(37)34-7-4-23(27,28)11-34)31-21(38)17-19(29)33-36-6-1-5-30-20(17)36/h1-3,5-6,8-9,22H,4,7,10-11H2,(H2,29,33)(H,31,38)
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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232625
PNG
(US9346815, 171)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCCNCC1
Show InChI InChI=1S/C23H23ClF2N8O2/c24-13-4-5-17(36-23(25)26)15(11-13)19-16(12-34(31-19)14-3-1-7-28-9-6-14)30-22(35)18-20(27)32-33-10-2-8-29-21(18)33/h2,4-5,8,10-12,14,23,28H,1,3,6-7,9H2,(H2,27,32)(H,30,35)
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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232638
PNG
(US9346815, 184)
Show SMILES CN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C23H23ClF2N8O2/c1-32-9-5-14(6-10-32)34-12-16(19(30-34)15-11-13(24)3-4-17(15)36-23(25)26)29-22(35)18-20(27)31-33-8-2-7-28-21(18)33/h2-4,7-8,11-12,14,23H,5-6,9-10H2,1H3,(H2,27,31)(H,29,35)
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Genentech, Inc.

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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232754
PNG
(US9346815, 300)
Show SMILES CCN(Cc1ccnc(Cl)c1)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C27H22Cl2F2N8O3/c1-2-37(13-16-6-8-32-22(29)10-16)23(40)15-38-14-20(35-26(41)19-12-34-39-9-3-7-33-25(19)39)24(36-38)18-11-17(28)4-5-21(18)42-27(30)31/h3-12,14,27H,2,13,15H2,1H3,(H,35,41)
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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232616
PNG
(US9346815, 162)
Show SMILES NC(=O)CCCN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C26H28ClF2N9O3/c27-15-4-5-19(41-26(28)29)17(13-15)22-18(33-25(40)21-23(31)35-37-10-2-8-32-24(21)37)14-38(34-22)16-6-11-36(12-7-16)9-1-3-20(30)39/h2,4-5,8,10,13-14,16,26H,1,3,6-7,9,11-12H2,(H2,30,39)(H2,31,35)(H,33,40)
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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232621
PNG
(US9346815, 167)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCN(CCCC(=O)NCc2ccccc2)CC1
Show InChI InChI=1S/C33H34ClF2N9O3/c34-22-9-10-26(48-33(35)36)24(18-22)29-25(40-32(47)28-30(37)42-44-15-5-13-38-31(28)44)20-45(41-29)23-11-16-43(17-12-23)14-4-8-27(46)39-19-21-6-2-1-3-7-21/h1-3,5-7,9-10,13,15,18,20,23,33H,4,8,11-12,14,16-17,19H2,(H2,37,42)(H,39,46)(H,40,47)
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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232597
PNG
(US9346815, 143)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCN(CCCC(=O)N2CCCCC2)CC1
Show InChI InChI=1S/C31H36ClF2N9O3/c32-20-7-8-24(46-31(33)34)22(18-20)27-23(37-30(45)26-28(35)39-42-15-5-11-36-29(26)42)19-43(38-27)21-9-16-40(17-10-21)12-4-6-25(44)41-13-2-1-3-14-41/h5,7-8,11,15,18-19,21,31H,1-4,6,9-10,12-14,16-17H2,(H2,35,39)(H,37,45)
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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232752
PNG
(US9346815, 298)
Show SMILES CN[C@H]1C[C@H](C1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C22H21ClF2N8O2/c1-27-12-8-13(9-12)33-10-15(18(30-33)14-7-11(23)3-4-16(14)35-22(24)25)29-21(34)17-19(26)31-32-6-2-5-28-20(17)32/h2-7,10,12-13,22,27H,8-9H2,1H3,(H2,26,31)(H,29,34)/t12-,13+
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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232730
PNG
(US9346815, 276)
Show SMILES OC1(CCN(CC1)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F)c1ccncc1
Show InChI InChI=1S/C29H25ClF2N8O4/c30-19-2-3-23(44-28(31)32)20(14-19)25-22(36-27(42)21-15-35-40-11-1-8-34-26(21)40)16-39(37-25)17-24(41)38-12-6-29(43,7-13-38)18-4-9-33-10-5-18/h1-5,8-11,14-16,28,43H,6-7,12-13,17H2,(H,36,42)
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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232456
PNG
(US9346815, 2)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCNCC1
Show InChI InChI=1S/C22H21ClF2N8O2/c23-12-2-3-16(35-22(24)25)14(10-12)18-15(11-33(30-18)13-4-7-27-8-5-13)29-21(34)17-19(26)31-32-9-1-6-28-20(17)32/h1-3,6,9-11,13,22,27H,4-5,7-8H2,(H2,26,31)(H,29,34)
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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232606
PNG
(US9346815, 152)
Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCN(CCCC(=O)NC2CCOCC2)CC1
Show InChI InChI=1S/C31H35ClF2N8O4/c32-20-4-5-26(46-31(33)34)23(17-20)28-25(38-30(44)24-18-36-41-12-2-10-35-29(24)41)19-42(39-28)22-6-13-40(14-7-22)11-1-3-27(43)37-21-8-15-45-16-9-21/h2,4-5,10,12,17-19,21-22,31H,1,3,6-9,11,13-16H2,(H,37,43)(H,38,44)
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Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM232796
PNG
(US9346815, 342)
Show SMILES OC(=O)C1CCN(CC1)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C25H22ClF2N7O5/c26-15-2-3-19(40-25(27)28)16(10-15)21-18(31-23(37)17-11-30-35-7-1-6-29-22(17)35)12-34(32-21)13-20(36)33-8-4-14(5-9-33)24(38)39/h1-3,6-7,10-12,14,25H,4-5,8-9,13H2,(H,31,37)(H,38,39)
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0.190n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232610
PNG
(US9346815, 156)
Show SMILES CCNC(=O)CCCN1CCC(CC1)n1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C28H31ClF2N8O3/c1-2-32-24(40)5-3-11-37-13-8-19(9-14-37)39-17-22(35-27(41)21-16-34-38-12-4-10-33-26(21)38)25(36-39)20-15-18(29)6-7-23(20)42-28(30)31/h4,6-7,10,12,15-17,19,28H,2-3,5,8-9,11,13-14H2,1H3,(H,32,40)(H,35,41)
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0.190n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232617
PNG
(US9346815, 163)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)C1CCN(CCCN2CCNC2=O)CC1
Show InChI InChI=1S/C28H31ClF2N10O3/c29-17-3-4-21(44-27(30)31)19(15-17)23-20(35-26(42)22-24(32)37-40-11-1-7-33-25(22)40)16-41(36-23)18-5-12-38(13-6-18)9-2-10-39-14-8-34-28(39)43/h1,3-4,7,11,15-16,18,27H,2,5-6,8-10,12-14H2,(H2,32,37)(H,34,43)(H,35,42)
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0.190n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232636
PNG
(US9346815, 182)
Show SMILES CN1CC[C@@H](C1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C22H21ClF2N8O2/c1-31-8-5-13(10-31)33-11-15(18(29-33)14-9-12(23)3-4-16(14)35-22(24)25)28-21(34)17-19(26)30-32-7-2-6-27-20(17)32/h2-4,6-7,9,11,13,22H,5,8,10H2,1H3,(H2,26,30)(H,28,34)/t13-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232603
PNG
(US9346815, 149)
Show SMILES CNC(=O)CCCN1CCC(CC1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C27H30ClF2N9O3/c1-32-21(40)4-2-10-37-12-7-17(8-13-37)39-15-19(23(35-39)18-14-16(28)5-6-20(18)42-27(29)30)34-26(41)22-24(31)36-38-11-3-9-33-25(22)38/h3,5-6,9,11,14-15,17,27H,2,4,7-8,10,12-13H2,1H3,(H2,31,36)(H,32,40)(H,34,41)
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0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232796
PNG
(US9346815, 342)
Show SMILES OC(=O)C1CCN(CC1)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C25H22ClF2N7O5/c26-15-2-3-19(40-25(27)28)16(10-15)21-18(31-23(37)17-11-30-35-7-1-6-29-22(17)35)12-34(32-21)13-20(36)33-8-4-14(5-9-33)24(38)39/h1-3,6-7,10-12,14,25H,4-5,8-9,13H2,(H,31,37)(H,38,39)
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0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232724
PNG
(US9346815, 270)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(CC(=O)N2CC[C@H](O)C2)nc1-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C23H21ClF2N8O4/c24-12-2-3-16(38-23(25)26)14(8-12)19-15(10-33(30-19)11-17(36)32-7-4-13(35)9-32)29-22(37)18-20(27)31-34-6-1-5-28-21(18)34/h1-3,5-6,8,10,13,23,35H,4,7,9,11H2,(H2,27,31)(H,29,37)/t13-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232781
PNG
(US9346815, 327)
Show SMILES Oc1cccc(CNCCn2cc(NC(=O)c3cnn4cccnc34)c(n2)-c2cc(Cl)ccc2OC(F)F)c1
Show InChI InChI=1S/C26H22ClF2N7O3/c27-17-5-6-22(39-26(28)29)19(12-17)23-21(33-25(38)20-14-32-36-9-2-7-31-24(20)36)15-35(34-23)10-8-30-13-16-3-1-4-18(37)11-16/h1-7,9,11-12,14-15,26,30,37H,8,10,13H2,(H,33,38)
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0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232640
PNG
(US9346815, 186)
Show SMILES Nc1nn2cccnc2c1C(=O)Nc1cn(nc1-c1cc(Cl)ccc1OC(F)F)[C@H]1CCNC1
Show InChI InChI=1S/C21H19ClF2N8O2/c22-11-2-3-15(34-21(23)24)13(8-11)17-14(10-32(29-17)12-4-6-26-9-12)28-20(33)16-18(25)30-31-7-1-5-27-19(16)31/h1-3,5,7-8,10,12,21,26H,4,6,9H2,(H2,25,30)(H,28,33)/t12-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM232767
PNG
(US9346815, 313)
Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(CCNCc2ccccc2)cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C26H22ClF2N7O2/c27-18-7-8-22(38-26(28)29)19(13-18)23-21(33-25(37)20-15-32-36-11-4-9-31-24(20)36)16-35(34-23)12-10-30-14-17-5-2-1-3-6-17/h1-9,11,13,15-16,26,30H,10,12,14H2,(H,33,37)
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0.210n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM232780
PNG
(US9346815, 326)
Show SMILES Oc1ccccc1CNCCn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C26H22ClF2N7O3/c27-17-6-7-22(39-26(28)29)18(12-17)23-20(33-25(38)19-14-32-36-10-3-8-31-24(19)36)15-35(34-23)11-9-30-13-16-4-1-2-5-21(16)37/h1-8,10,12,14-15,26,30,37H,9,11,13H2,(H,33,38)
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0.210n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM232767
PNG
(US9346815, 313)
Show SMILES FC(F)Oc1ccc(Cl)cc1-c1nn(CCNCc2ccccc2)cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C26H22ClF2N7O2/c27-18-7-8-22(38-26(28)29)19(13-18)23-21(33-25(37)20-15-32-36-11-4-9-31-24(20)36)16-35(34-23)12-10-30-14-17-5-2-1-3-6-17/h1-9,11,13,15-16,26,30H,10,12,14H2,(H,33,37)
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0.210n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


Citation and Details
More data for this
Ligand-Target Pair
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