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Patent code US9346818

Compile Data Set for Download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231517
PNG
(US9346818, I-2)
Show SMILES Fc1ccccc1CN1CCC(CCN2C(=O)c3cc4OCOc4cc3C2=O)CC1
Show InChI InChI=1S/C23H23FN2O4/c24-19-4-2-1-3-16(19)13-25-8-5-15(6-9-25)7-10-26-22(27)17-11-20-21(30-14-29-20)12-18(17)23(26)28/h1-4,11-12,15H,5-10,13-14H2
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n/an/a 80n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231516
PNG
(US9346818, I-1)
Show SMILES O=C1N(CCC2CCN(Cc3ccccc3)CC2)C(=O)c2cc3OCOc3cc12
Show InChI InChI=1S/C23H24N2O4/c26-22-18-12-20-21(29-15-28-20)13-19(18)23(27)25(22)11-8-16-6-9-24(10-7-16)14-17-4-2-1-3-5-17/h1-5,12-13,16H,6-11,14-15H2
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n/an/a 86n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM8960
PNG
((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Show SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC
Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
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US Patent
n/an/a 94n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231533
PNG
(US9346818, I-18)
Show SMILES Fc1ccccc1CN1CCC(CCN2C(=O)c3cc4OCOc4cc3C22CC2)CC1
Show InChI InChI=1S/C25H27FN2O3/c26-21-4-2-1-3-18(21)15-27-10-5-17(6-11-27)7-12-28-24(29)19-13-22-23(31-16-30-22)14-20(19)25(28)8-9-25/h1-4,13-14,17H,5-12,15-16H2
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231551
PNG
(US9346818, I-36)
Show SMILES O=C1N(CCC2CCN(Cc3ccccn3)CC2)C(=O)c2cc3OCOc3cc12
Show InChI InChI=1S/C22H23N3O4/c26-21-17-11-19-20(29-14-28-19)12-18(17)22(27)25(21)10-6-15-4-8-24(9-5-15)13-16-3-1-2-7-23-16/h1-3,7,11-12,15H,4-6,8-10,13-14H2
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n/an/a 161n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231519
PNG
(US9346818, I-4)
Show SMILES Fc1ccc(CN2CCC(CCN3C(=O)c4cc5OCOc5cc4C3=O)CC2)cc1
Show InChI InChI=1S/C23H23FN2O4/c24-17-3-1-16(2-4-17)13-25-8-5-15(6-9-25)7-10-26-22(27)18-11-20-21(30-14-29-20)12-19(18)23(26)28/h1-4,11-12,15H,5-10,13-14H2
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231532
PNG
(US9346818, I-17 | US9346818, I-34)
Show SMILES O=C1N(CCC2CCN(Cc3ccccc3)CC2)C2(CC2)c2cc3OCOc3cc12
Show InChI InChI=1S/C25H28N2O3/c28-24-20-14-22-23(30-17-29-22)15-21(20)25(9-10-25)27(24)13-8-18-6-11-26(12-7-18)16-19-4-2-1-3-5-19/h1-5,14-15,18H,6-13,16-17H2
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231532
PNG
(US9346818, I-17 | US9346818, I-34)
Show SMILES O=C1N(CCC2CCN(Cc3ccccc3)CC2)C2(CC2)c2cc3OCOc3cc12
Show InChI InChI=1S/C25H28N2O3/c28-24-20-14-22-23(30-17-29-22)15-21(20)25(9-10-25)27(24)13-8-18-6-11-26(12-7-18)16-19-4-2-1-3-5-19/h1-5,14-15,18H,6-13,16-17H2
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231525
PNG
(US9346818, I-10)
Show SMILES CC1N(CCC2CCN(Cc3ccccc3F)CC2)C(=O)c2cc3OCOc3cc12
Show InChI InChI=1S/C24H27FN2O3/c1-16-19-12-22-23(30-15-29-22)13-20(19)24(28)27(16)11-8-17-6-9-26(10-7-17)14-18-4-2-3-5-21(18)25/h2-5,12-13,16-17H,6-11,14-15H2,1H3
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231540
PNG
(US9346818, I-25)
Show SMILES Fc1cccc(F)c1CN1CCC(CCN2C(=O)c3cc4OCOc4cc3C22CC2)CC1
Show InChI InChI=1S/C25H26F2N2O3/c26-20-2-1-3-21(27)18(20)14-28-9-4-16(5-10-28)6-11-29-24(30)17-12-22-23(32-15-31-22)13-19(17)25(29)7-8-25/h1-3,12-13,16H,4-11,14-15H2
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231518
PNG
(US9346818, I-3)
Show SMILES Fc1cccc(CN2CCC(CCN3C(=O)c4cc5OCOc5cc4C3=O)CC2)c1
Show InChI InChI=1S/C23H23FN2O4/c24-17-3-1-2-16(10-17)13-25-7-4-15(5-8-25)6-9-26-22(27)18-11-20-21(30-14-29-20)12-19(18)23(26)28/h1-3,10-12,15H,4-9,13-14H2
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n/an/a 269n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231534
PNG
(US9346818, I-19)
Show SMILES Fc1cccc(CN2CCC(CCN3C(=O)c4cc5OCOc5cc4C33CC3)CC2)c1
Show InChI InChI=1S/C25H27FN2O3/c26-19-3-1-2-18(12-19)15-27-9-4-17(5-10-27)6-11-28-24(29)20-13-22-23(31-16-30-22)14-21(20)25(28)7-8-25/h1-3,12-14,17H,4-11,15-16H2
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231521
PNG
(US9346818, I-6)
Show SMILES Fc1ccccc1CN1CCC(CCN2Cc3cc4OCOc4cc3C2=O)CC1
Show InChI InChI=1S/C23H25FN2O3/c24-20-4-2-1-3-17(20)13-25-8-5-16(6-9-25)7-10-26-14-18-11-21-22(29-15-28-21)12-19(18)23(26)27/h1-4,11-12,16H,5-10,13-15H2
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231522
PNG
(US9346818, I-7)
Show SMILES Fc1cccc(CN2CCC(CCN3Cc4cc5OCOc5cc4C3=O)CC2)c1
Show InChI InChI=1S/C23H25FN2O3/c24-19-3-1-2-17(10-19)13-25-7-4-16(5-8-25)6-9-26-14-18-11-21-22(29-15-28-21)12-20(18)23(26)27/h1-3,10-12,16H,4-9,13-15H2
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n/an/a 486n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231520
PNG
(US9346818, I-5)
Show SMILES O=C1N(CCC2CCN(Cc3ccccc3)CC2)Cc2cc3OCOc3cc12
Show InChI InChI=1S/C23H26N2O3/c26-23-20-13-22-21(27-16-28-22)12-19(20)15-25(23)11-8-17-6-9-24(10-7-17)14-18-4-2-1-3-5-18/h1-5,12-13,17H,6-11,14-16H2
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n/an/a 502n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231544
PNG
(US9346818, I-29 | US9346818, I-33 | US9346818, I-3...)
Show SMILES O=C1N(CCC2CCN(Cc3ccccn3)CC2)C2(CC2)c2cc3OCOc3cc12
Show InChI InChI=1S/C24H27N3O3/c28-23-19-13-21-22(30-16-29-21)14-20(19)24(7-8-24)27(23)12-6-17-4-10-26(11-5-17)15-18-3-1-2-9-25-18/h1-3,9,13-14,17H,4-8,10-12,15-16H2
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231524
PNG
(US9346818, I-9)
Show SMILES CC1N(CCC2CCN(Cc3ccccc3)CC2)C(=O)c2cc3OCOc3cc12
Show InChI InChI=1S/C24H28N2O3/c1-17-20-13-22-23(29-16-28-22)14-21(20)24(27)26(17)12-9-18-7-10-25(11-8-18)15-19-5-3-2-4-6-19/h2-6,13-14,17-18H,7-12,15-16H2,1H3
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231536
PNG
(US9346818, I-21)
Show SMILES Clc1ccccc1CN1CCC(CCN2C(=O)c3cc4OCOc4cc3C22CC2)CC1
Show InChI InChI=1S/C25H27ClN2O3/c26-21-4-2-1-3-18(21)15-27-10-5-17(6-11-27)7-12-28-24(29)19-13-22-23(31-16-30-22)14-20(19)25(28)8-9-25/h1-4,13-14,17H,5-12,15-16H2
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n/an/a 653n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231523
PNG
(US9346818, I-8)
Show SMILES Fc1ccc(CN2CCC(CCN3Cc4cc5OCOc5cc4C3=O)CC2)cc1
Show InChI InChI=1S/C23H25FN2O3/c24-19-3-1-17(2-4-19)13-25-8-5-16(6-9-25)7-10-26-14-18-11-21-22(29-15-28-21)12-20(18)23(26)27/h1-4,11-12,16H,5-10,13-15H2
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n/an/a 658n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231535
PNG
(US9346818, I-20)
Show SMILES Fc1ccc(CN2CCC(CCN3C(=O)c4cc5OCOc5cc4C33CC3)CC2)cc1
Show InChI InChI=1S/C25H27FN2O3/c26-19-3-1-18(2-4-19)15-27-10-5-17(6-11-27)7-12-28-24(29)20-13-22-23(31-16-30-22)14-21(20)25(28)8-9-25/h1-4,13-14,17H,5-12,15-16H2
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n/an/a 706n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231526
PNG
(US9346818, I-11)
Show SMILES CC1N(CCC2CCN(Cc3cccc(F)c3)CC2)C(=O)c2cc3OCOc3cc12
Show InChI InChI=1S/C24H27FN2O3/c1-16-20-12-22-23(30-15-29-22)13-21(20)24(28)27(16)10-7-17-5-8-26(9-6-17)14-18-3-2-4-19(25)11-18/h2-4,11-13,16-17H,5-10,14-15H2,1H3
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n/an/a 889n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231544
PNG
(US9346818, I-29 | US9346818, I-33 | US9346818, I-3...)
Show SMILES O=C1N(CCC2CCN(Cc3ccccn3)CC2)C2(CC2)c2cc3OCOc3cc12
Show InChI InChI=1S/C24H27N3O3/c28-23-19-13-21-22(30-16-29-21)14-20(19)24(7-8-24)27(23)12-6-17-4-10-26(11-5-17)15-18-3-1-2-9-25-18/h1-3,9,13-14,17H,4-8,10-12,15-16H2
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n/an/a 903n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231552
PNG
(US9346818, I-37)
Show SMILES O=C1N(CCC2CCN(Cc3cccnn3)CC2)C(=O)c2cc3OCOc3cc12
Show InChI InChI=1S/C21H22N4O4/c26-20-16-10-18-19(29-13-28-18)11-17(16)21(27)25(20)9-5-14-3-7-24(8-4-14)12-15-2-1-6-22-23-15/h1-2,6,10-11,14H,3-5,7-9,12-13H2
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n/an/a 905n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231544
PNG
(US9346818, I-29 | US9346818, I-33 | US9346818, I-3...)
Show SMILES O=C1N(CCC2CCN(Cc3ccccn3)CC2)C2(CC2)c2cc3OCOc3cc12
Show InChI InChI=1S/C24H27N3O3/c28-23-19-13-21-22(30-16-29-21)14-20(19)24(7-8-24)27(23)12-6-17-4-10-26(11-5-17)15-18-3-1-2-9-25-18/h1-3,9,13-14,17H,4-8,10-12,15-16H2
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n/an/a 950n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231538
PNG
(US9346818, I-23)
Show SMILES Cc1ccccc1CN1CCC(CCN2C(=O)c3cc4OCOc4cc3C22CC2)CC1
Show InChI InChI=1S/C26H30N2O3/c1-18-4-2-3-5-20(18)16-27-11-6-19(7-12-27)8-13-28-25(29)21-14-23-24(31-17-30-23)15-22(21)26(28)9-10-26/h2-5,14-15,19H,6-13,16-17H2,1H3
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n/an/a 959n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231556
PNG
(US9346818, I-41)
Show SMILES O=C1N(CCC2CCN(Cc3ccn[nH]3)CC2)C2(CC2)c2cc3OCOc3cc12
Show InChI InChI=1S/C22H26N4O3/c27-21-17-11-19-20(29-14-28-19)12-18(17)22(5-6-22)26(21)10-4-15-2-8-25(9-3-15)13-16-1-7-23-24-16/h1,7,11-12,15H,2-6,8-10,13-14H2,(H,23,24)
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n/an/a 990n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231529
PNG
(US9346818, I-14)
Show SMILES CC1(C)N(CCC2CCN(Cc3ccccc3F)CC2)C(=O)c2cc3OCOc3cc12
Show InChI InChI=1S/C25H29FN2O3/c1-25(2)20-14-23-22(30-16-31-23)13-19(20)24(29)28(25)12-9-17-7-10-27(11-8-17)15-18-5-3-4-6-21(18)26/h3-6,13-14,17H,7-12,15-16H2,1-2H3
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231542
PNG
(US9346818, I-27)
Show SMILES COc1cccc(CN2CCC(CCN3C(=O)c4cc5OCOc5cc4C33CC3)CC2)c1
Show InChI InChI=1S/C26H30N2O4/c1-30-20-4-2-3-19(13-20)16-27-10-5-18(6-11-27)7-12-28-25(29)21-14-23-24(32-17-31-23)15-22(21)26(28)8-9-26/h2-4,13-15,18H,5-12,16-17H2,1H3
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n/an/a>2.00E+3n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231537
PNG
(US9346818, I-22)
Show SMILES FC(F)(F)c1ccccc1CN1CCC(CCN2C(=O)c3cc4OCOc4cc3C22CC2)CC1
Show InChI InChI=1S/C26H27F3N2O3/c27-26(28,29)20-4-2-1-3-18(20)15-30-10-5-17(6-11-30)7-12-31-24(32)19-13-22-23(34-16-33-22)14-21(19)25(31)8-9-25/h1-4,13-14,17H,5-12,15-16H2
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231553
PNG
(US9346818, I-38)
Show SMILES O=C1N(CCC2CCN(Cc3cccnn3)CC2)C2(CC2)c2cc3OCOc3cc12
Show InChI InChI=1S/C23H26N4O3/c28-22-18-12-20-21(30-15-29-20)13-19(18)23(6-7-23)27(22)11-5-16-3-9-26(10-4-16)14-17-2-1-8-24-25-17/h1-2,8,12-13,16H,3-7,9-11,14-15H2
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n/an/a>2.00E+3n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231546
PNG
(US9346818, I-31)
Show SMILES O=C1N(CCC2CCN(Cc3ccncc3)CC2)C2(CC2)c2cc3OCOc3cc12
Show InChI InChI=1S/C24H27N3O3/c28-23-19-13-21-22(30-16-29-21)14-20(19)24(6-7-24)27(23)12-5-17-3-10-26(11-4-17)15-18-1-8-25-9-2-18/h1-2,8-9,13-14,17H,3-7,10-12,15-16H2
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231528
PNG
(US9346818, I-13)
Show SMILES CC1(C)N(CCC2CCN(Cc3ccccc3)CC2)C(=O)c2cc3OCOc3cc12
Show InChI InChI=1S/C25H30N2O3/c1-25(2)21-15-23-22(29-17-30-23)14-20(21)24(28)27(25)13-10-18-8-11-26(12-9-18)16-19-6-4-3-5-7-19/h3-7,14-15,18H,8-13,16-17H2,1-2H3
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n/an/a>2.00E+3n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231530
PNG
(US9346818, I-15)
Show SMILES CC1(C)N(CCC2CCN(Cc3cccc(F)c3)CC2)C(=O)c2cc3OCOc3cc12
Show InChI InChI=1S/C25H29FN2O3/c1-25(2)21-14-23-22(30-16-31-23)13-20(21)24(29)28(25)11-8-17-6-9-27(10-7-17)15-18-4-3-5-19(26)12-18/h3-5,12-14,17H,6-11,15-16H2,1-2H3
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231541
PNG
(US9346818, I-26)
Show SMILES COc1ccccc1CN1CCC(CCN2C(=O)c3cc4OCOc4cc3C22CC2)CC1
Show InChI InChI=1S/C26H30N2O4/c1-30-22-5-3-2-4-19(22)16-27-11-6-18(7-12-27)8-13-28-25(29)20-14-23-24(32-17-31-23)15-21(20)26(28)9-10-26/h2-5,14-15,18H,6-13,16-17H2,1H3
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231531
PNG
(US9346818, I-16)
Show SMILES CC1(C)N(CCC2CCN(Cc3ccc(F)cc3)CC2)C(=O)c2cc3OCOc3cc12
Show InChI InChI=1S/C25H29FN2O3/c1-25(2)21-14-23-22(30-16-31-23)13-20(21)24(29)28(25)12-9-17-7-10-27(11-8-17)15-18-3-5-19(26)6-4-18/h3-6,13-14,17H,7-12,15-16H2,1-2H3
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231543
PNG
(US9346818, I-28)
Show SMILES COc1ccc(CN2CCC(CCN3C(=O)c4cc5OCOc5cc4C33CC3)CC2)cc1
Show InChI InChI=1S/C26H30N2O4/c1-30-20-4-2-19(3-5-20)16-27-11-6-18(7-12-27)8-13-28-25(29)21-14-23-24(32-17-31-23)15-22(21)26(28)9-10-26/h2-5,14-15,18H,6-13,16-17H2,1H3
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231554
PNG
(US9346818, I-39)
Show SMILES O=C1N(CCC2CCN(Cc3ccc[nH]3)CC2)C2(CC2)c2cc3OCOc3cc12
Show InChI InChI=1S/C23H27N3O3/c27-22-18-12-20-21(29-15-28-20)13-19(18)23(6-7-23)26(22)11-5-16-3-9-25(10-4-16)14-17-2-1-8-24-17/h1-2,8,12-13,16,24H,3-7,9-11,14-15H2
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231527
PNG
(US9346818, I-12)
Show SMILES CC1N(CCC2CCN(Cc3ccc(F)cc3)CC2)C(=O)c2cc3OCOc3cc12
Show InChI InChI=1S/C24H27FN2O3/c1-16-20-12-22-23(30-15-29-22)13-21(20)24(28)27(16)11-8-17-6-9-26(10-7-17)14-18-2-4-19(25)5-3-18/h2-5,12-13,16-17H,6-11,14-15H2,1H3
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231547
PNG
(US9346818, I-32)
Show SMILES O=C1N(CCC2CCN(Cc3ncccn3)CC2)C2(CC2)c2cc3OCOc3cc12
Show InChI InChI=1S/C23H26N4O3/c28-22-17-12-19-20(30-15-29-19)13-18(17)23(5-6-23)27(22)11-4-16-2-9-26(10-3-16)14-21-24-7-1-8-25-21/h1,7-8,12-13,16H,2-6,9-11,14-15H2
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231545
PNG
(US9346818, I-30)
Show SMILES O=C1N(CCC2CCN(Cc3cccnc3)CC2)C2(CC2)c2cc3OCOc3cc12
Show InChI InChI=1S/C24H27N3O3/c28-23-19-12-21-22(30-16-29-21)13-20(19)24(6-7-24)27(23)11-5-17-3-9-26(10-4-17)15-18-2-1-8-25-14-18/h1-2,8,12-14,17H,3-7,9-11,15-16H2
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231555
PNG
(US9346818, I-40)
Show SMILES Cc1ccc(CN2CCC(CCN3C(=O)c4cc5OCOc5cc4C33CC3)CC2)[nH]1
Show InChI InChI=1S/C24H29N3O3/c1-16-2-3-18(25-16)14-26-9-4-17(5-10-26)6-11-27-23(28)19-12-21-22(30-15-29-21)13-20(19)24(27)7-8-24/h2-3,12-13,17,25H,4-11,14-15H2,1H3
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM231539
PNG
(US9346818, I-24)
Show SMILES O=C1N(CCC2CCN(Cc3ccccc3C#N)CC2)C2(CC2)c2cc3OCOc3cc12
Show InChI InChI=1S/C26H27N3O3/c27-15-19-3-1-2-4-20(19)16-28-10-5-18(6-11-28)7-12-29-25(30)21-13-23-24(32-17-31-23)14-22(21)26(29)8-9-26/h1-4,13-14,18H,5-12,16-17H2
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Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
Modified Ellman method (Alvin V. et al. JWS-USC-75-IX Improves Information Processing and Cognitive Function in Animal Models[J]. Journal of Pharmaco...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%