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Patent code US9351965

Compile Data Set for Download or QSAR
Found 152 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233415
PNG
(US9351965, 22)
Show SMILES COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1S/C28H29FN4O3/c1-17-13-18(10-12-30-17)26-21-14-19(8-9-24(21)32-33-26)27(34)31-20-5-4-11-28(35,15-20)16-22-23(29)6-3-7-25(22)36-2/h3,6-10,12-14,20,35H,4-5,11,15-16H2,1-2H3,(H,31,34)(H,32,33)/t20-,28-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233416
PNG
(US9351965, 23)
Show SMILES COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1
Show InChI InChI=1S/C29H28FN5O3/c1-38-25-6-2-5-23(30)22(25)16-29(37)11-3-4-20(15-29)32-28(36)18-7-9-24-21(14-18)27(34-33-24)19-8-10-26-31-12-13-35(26)17-19/h2,5-10,12-14,17,20,37H,3-4,11,15-16H2,1H3,(H,32,36)(H,33,34)/t20-,29-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233459
PNG
(US9351965, 66)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ncc3ccccc23)C1
Show InChI InChI=1S/C28H28N6O2/c1-18-13-19(10-12-29-18)26-23-14-20(8-9-24(23)32-33-26)27(35)31-22-6-4-11-28(36,15-22)17-34-25-7-3-2-5-21(25)16-30-34/h2-3,5,7-10,12-14,16,22,36H,4,6,11,15,17H2,1H3,(H,31,35)(H,32,33)/t22-,28+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233394
PNG
(US9351965, 1 | US9351965, 2 | US9351965, 3 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2ccccc2F)C1
Show InChI InChI=1S/C27H27FN4O2/c1-17-13-18(10-12-29-17)25-22-14-19(8-9-24(22)31-32-25)26(33)30-21-6-4-11-27(34,16-21)15-20-5-2-3-7-23(20)28/h2-3,5,7-10,12-14,21,34H,4,6,11,15-16H2,1H3,(H,30,33)(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233472
PNG
(US9351965, 79)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ncc3cccnc23)C1
Show InChI InChI=1S/C27H27N7O2/c1-17-12-18(8-11-28-17)24-22-13-19(6-7-23(22)32-33-24)26(35)31-21-5-2-9-27(36,14-21)16-34-25-20(15-30-34)4-3-10-29-25/h3-4,6-8,10-13,15,21,36H,2,5,9,14,16H2,1H3,(H,31,35)(H,32,33)/t21-,27+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233408
PNG
(US9351965, 15)
Show SMILES O[C@]1(Cc2ccccc2F)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1
Show InChI InChI=1S/C28H26FN5O2/c29-23-6-2-1-4-19(23)15-28(36)11-3-5-21(16-28)31-27(35)18-7-9-24-22(14-18)26(33-32-24)20-8-10-25-30-12-13-34(25)17-20/h1-2,4,6-10,12-14,17,21,36H,3,5,11,15-16H2,(H,31,35)(H,32,33)/t21-,28+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233417
PNG
(US9351965, 24)
Show SMILES COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(C)sc4c3)c2c1
Show InChI InChI=1S/C30H29FN4O3S/c1-17-32-25-11-8-18(14-27(25)39-17)28-21-13-19(9-10-24(21)34-35-28)29(36)33-20-5-4-12-30(37,15-20)16-22-23(31)6-3-7-26(22)38-2/h3,6-11,13-14,20,37H,4-5,12,15-16H2,1-2H3,(H,33,36)(H,34,35)/t20-,30-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233516
PNG
(US9351965, 123)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3ccccc23)C1
Show InChI InChI=1S/C28H28N6O/c1-18-13-20(11-12-29-18)27-24-15-21(9-10-25(24)32-33-27)28(35)31-23-7-4-5-19(14-23)17-34-26-8-3-2-6-22(26)16-30-34/h2-3,6,8-13,15-16,19,23H,4-5,7,14,17H2,1H3,(H,31,35)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233485
PNG
(US9351965, 92)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(CN2C(=O)Cc3ccccc23)C1
Show InChI InChI=1S/C29H29N5O3/c1-18-13-20(10-12-30-18)27-23-14-21(8-9-24(23)32-33-27)28(36)31-22-6-4-11-29(37,16-22)17-34-25-7-3-2-5-19(25)15-26(34)35/h2-3,5,7-10,12-14,22,37H,4,6,11,15-17H2,1H3,(H,31,36)(H,32,33)/t22-,29+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233435
PNG
(US9351965, 42)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)(Oc1cccc(F)c1)C(N)=O
Show InChI InChI=1S/C27H26FN5O3/c1-16-12-17(9-11-30-16)24-22-13-18(7-8-23(22)32-33-24)25(34)31-20-5-3-10-27(15-20,26(29)35)36-21-6-2-4-19(28)14-21/h2,4,6-9,11-14,20H,3,5,10,15H2,1H3,(H2,29,35)(H,31,34)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233412
PNG
(US9351965, 19)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2c(F)cccc2F)C1
Show InChI InChI=1S/C29H27F2N5O2/c1-36-16-19-12-17(7-9-25(19)35-36)27-21-13-18(8-10-26(21)33-34-27)28(37)32-20-4-3-11-29(38,14-20)15-22-23(30)5-2-6-24(22)31/h2,5-10,12-13,16,20,38H,3-4,11,14-15H2,1H3,(H,32,37)(H,33,34)/t20-,29-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233436
PNG
(US9351965, 43 | US9351965, 44 | US9351965, 45)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(C1)Oc1cccc(F)c1
Show InChI InChI=1S/C27H27FN4O3/c1-17-12-18(9-11-29-17)25-23-13-19(7-8-24(23)31-32-25)26(34)30-21-5-3-10-27(15-21,16-33)35-22-6-2-4-20(28)14-22/h2,4,6-9,11-14,21,33H,3,5,10,15-16H2,1H3,(H,30,34)(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233515
PNG
(US9351965, 122)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cc3ccccc3n2)C1
Show InChI InChI=1S/C28H28N6O/c1-18-13-20(11-12-29-18)27-24-15-21(9-10-26(24)31-32-27)28(35)30-23-7-4-5-19(14-23)16-34-17-22-6-2-3-8-25(22)33-34/h2-3,6,8-13,15,17,19,23H,4-5,7,14,16H2,1H3,(H,30,35)(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233405
PNG
(US9351965, 12)
Show SMILES Cc1nc2ccc(cn2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2ccccc2F)C1
Show InChI InChI=1S/C28H27FN6O2/c1-17-30-25-11-9-20(16-35(25)34-17)26-22-13-18(8-10-24(22)32-33-26)27(36)31-21-6-4-12-28(37,15-21)14-19-5-2-3-7-23(19)29/h2-3,5,7-11,13,16,21,37H,4,6,12,14-15H2,1H3,(H,31,36)(H,32,33)/t21-,28+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233398
PNG
(US9351965, 5 | US9351965, 6 | US9351965, 7 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2c(F)cccc2F)C1
Show InChI InChI=1S/C27H26F2N4O2/c1-16-12-17(9-11-30-16)25-20-13-18(7-8-24(20)32-33-25)26(34)31-19-4-3-10-27(35,14-19)15-21-22(28)5-2-6-23(21)29/h2,5-9,11-13,19,35H,3-4,10,14-15H2,1H3,(H,31,34)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233407
PNG
(US9351965, 14)
Show SMILES Cc1nc2ccc(cc2s1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2c(F)cccc2F)C1
Show InChI InChI=1S/C29H26F2N4O2S/c1-16-32-25-10-7-17(13-26(25)38-16)27-20-12-18(8-9-24(20)34-35-27)28(36)33-19-4-3-11-29(37,14-19)15-21-22(30)5-2-6-23(21)31/h2,5-10,12-13,19,37H,3-4,11,14-15H2,1H3,(H,33,36)(H,34,35)/t19-,29-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233507
PNG
(US9351965, 114)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3cccnc23)C1
Show InChI InChI=1S/C27H27N7O/c1-17-12-19(9-11-28-17)25-23-14-20(7-8-24(23)32-33-25)27(35)31-22-6-2-4-18(13-22)16-34-26-21(15-30-34)5-3-10-29-26/h3,5,7-12,14-15,18,22H,2,4,6,13,16H2,1H3,(H,31,35)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233513
PNG
(US9351965, 120)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CN2C(=O)Cc3ccccc23)C1
Show InChI InChI=1S/C29H29N5O2/c1-18-13-21(11-12-30-18)28-24-15-22(9-10-25(24)32-33-28)29(36)31-23-7-4-5-19(14-23)17-34-26-8-3-2-6-20(26)16-27(34)35/h2-3,6,8-13,15,19,23H,4-5,7,14,16-17H2,1H3,(H,31,36)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233531
PNG
(US9351965, 138 | US9351965, 139)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCC(CO)(Cc2ccccc2F)C1
Show InChI InChI=1S/C27H27FN4O2/c1-17-12-18(9-11-29-17)25-22-13-19(6-7-24(22)31-32-25)26(34)30-21-8-10-27(15-21,16-33)14-20-4-2-3-5-23(20)28/h2-7,9,11-13,21,33H,8,10,14-16H2,1H3,(H,30,34)(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233454
PNG
(US9351965, 61)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cnc3ccccc23)C1
Show InChI InChI=1S/C30H29N7O2/c1-36-16-21-13-19(8-10-24(21)35-36)28-23-14-20(9-11-25(23)33-34-28)29(38)32-22-5-4-12-30(39,15-22)17-37-18-31-26-6-2-3-7-27(26)37/h2-3,6-11,13-14,16,18,22,39H,4-5,12,15,17H2,1H3,(H,32,38)(H,33,34)/t22-,30-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233455
PNG
(US9351965, 62)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cnc3ccccc23)C1
Show InChI InChI=1S/C30H29N7O2/c1-36-16-21-13-19(8-10-24(21)35-36)28-23-14-20(9-11-25(23)33-34-28)29(38)32-22-5-4-12-30(39,15-22)17-37-18-31-26-6-2-3-7-27(26)37/h2-3,6-11,13-14,16,18,22,39H,4-5,12,15,17H2,1H3,(H,32,38)(H,33,34)/t22-,30+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233406
PNG
(US9351965, 13)
Show SMILES Cc1nc2ccc(cc2s1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2ccccc2F)C1
Show InChI InChI=1S/C29H27FN4O2S/c1-17-31-25-11-8-18(14-26(25)37-17)27-22-13-19(9-10-24(22)33-34-27)28(35)32-21-6-4-12-29(36,16-21)15-20-5-2-3-7-23(20)30/h2-3,5,7-11,13-14,21,36H,4,6,12,15-16H2,1H3,(H,32,35)(H,33,34)/t21-,29+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233394
PNG
(US9351965, 1 | US9351965, 2 | US9351965, 3 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2ccccc2F)C1
Show InChI InChI=1S/C27H27FN4O2/c1-17-13-18(10-12-29-17)25-22-14-19(8-9-24(22)31-32-25)26(33)30-21-6-4-11-27(34,16-21)15-20-5-2-3-7-23(20)28/h2-3,5,7-10,12-14,21,34H,4,6,11,15-16H2,1H3,(H,30,33)(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233414
PNG
(US9351965, 21)
Show SMILES Cc1nc2ccc(cn2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2c(F)cccc2F)C1
Show InChI InChI=1S/C28H26F2N6O2/c1-16-31-25-10-8-18(15-36(25)35-16)26-20-12-17(7-9-24(20)33-34-26)27(37)32-19-4-3-11-28(38,13-19)14-21-22(29)5-2-6-23(21)30/h2,5-10,12,15,19,38H,3-4,11,13-14H2,1H3,(H,32,37)(H,33,34)/t19-,28-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233502
PNG
(US9351965, 109)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cnc3ccccc23)C1
Show InChI InChI=1S/C30H29N7O/c1-36-17-22-14-20(9-11-25(22)35-36)29-24-15-21(10-12-26(24)33-34-29)30(38)32-23-6-4-5-19(13-23)16-37-18-31-27-7-2-3-8-28(27)37/h2-3,7-12,14-15,17-19,23H,4-6,13,16H2,1H3,(H,32,38)(H,33,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233496
PNG
(US9351965, 103)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@](O)(Cn2ncc3c(F)cccc23)C1
Show InChI InChI=1S/C28H27FN6O2/c1-17-12-18(9-11-30-17)26-21-13-19(7-8-24(21)33-34-26)27(36)32-20-4-3-10-28(37,14-20)16-35-25-6-2-5-23(29)22(25)15-31-35/h2,5-9,11-13,15,20,37H,3-4,10,14,16H2,1H3,(H,32,36)(H,33,34)/t20-,28+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233442
PNG
(US9351965, 49 | US9351965, 50 | US9351965, 51 | US...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(O)c1ccccc1
Show InChI InChI=1S/C27H28N4O3/c1-17-14-19(11-13-28-17)24-22-15-20(9-10-23(22)30-31-24)26(33)29-21-8-5-12-27(34,16-21)25(32)18-6-3-2-4-7-18/h2-4,6-7,9-11,13-15,21,25,32,34H,5,8,12,16H2,1H3,(H,29,33)(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233535
PNG
(US9351965, 142 | US9351965, 143)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1F
Show InChI InChI=1S/C25H24FN5O2/c1-16-13-17(10-11-27-16)24-20-14-18(8-9-22(20)28-29-24)25(32)30-31-12-4-5-19(15-31)33-23-7-3-2-6-21(23)26/h2-3,6-11,13-14,19H,4-5,12,15H2,1H3,(H,28,29)(H,30,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233483
PNG
(US9351965, 90)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cc3ccccc3n2)C1
Show InChI InChI=1S/C28H28N6O2/c1-18-13-19(10-12-29-18)26-23-14-20(8-9-25(23)31-32-26)27(35)30-22-6-4-11-28(36,15-22)17-34-16-21-5-2-3-7-24(21)33-34/h2-3,5,7-10,12-14,16,22,36H,4,6,11,15,17H2,1H3,(H,30,35)(H,31,32)/t22-,28-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233432
PNG
(US9351965, 39 | US9351965, 40)
Show SMILES COC1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1S/C28H29FN4O2/c1-18-14-19(11-13-30-18)26-23-15-20(9-10-25(23)32-33-26)27(34)31-22-7-5-12-28(17-22,35-2)16-21-6-3-4-8-24(21)29/h3-4,6,8-11,13-15,22H,5,7,12,16-17H2,1-2H3,(H,31,34)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233538
PNG
(US9351965, 145)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC1CCc1ccccc1
Show InChI InChI=1S/C26H27N5O/c1-18-16-20(13-14-27-18)25-23-17-21(10-12-24(23)28-29-25)26(32)30-31-15-5-8-22(31)11-9-19-6-3-2-4-7-19/h2-4,6-7,10,12-14,16-17,22H,5,8-9,11,15H2,1H3,(H,28,29)(H,30,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233501
PNG
(US9351965, 108)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ccnc2)C1
Show InChI InChI=1S/C26H27N7O/c1-32-15-20-12-18(5-7-23(20)31-32)25-22-13-19(6-8-24(22)29-30-25)26(34)28-21-4-2-3-17(11-21)14-33-10-9-27-16-33/h5-10,12-13,15-17,21H,2-4,11,14H2,1H3,(H,28,34)(H,29,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233429
PNG
(US9351965, 140 | US9351965, 141 | US9351965, 36)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1Cl
Show InChI InChI=1S/C25H24ClN5O2/c1-16-13-17(10-11-27-16)24-20-14-18(8-9-22(20)28-29-24)25(32)30-31-12-4-5-19(15-31)33-23-7-3-2-6-21(23)26/h2-3,6-11,13-14,19H,4-5,12,15H2,1H3,(H,28,29)(H,30,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233543
PNG
(US9351965, 150)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCC(CO)(Cc2ccccc2F)C1
Show InChI InChI=1S/C26H26FN5O2/c1-17-12-18(8-10-28-17)24-21-13-19(6-7-23(21)29-30-24)25(34)31-32-11-9-26(15-32,16-33)14-20-4-2-3-5-22(20)27/h2-8,10,12-13,33H,9,11,14-16H2,1H3,(H,29,30)(H,31,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233508
PNG
(US9351965, 115)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3ccncc23)C1
Show InChI InChI=1S/C27H27N7O/c1-17-11-19(8-10-29-17)26-23-13-20(5-6-24(23)32-33-26)27(35)31-22-4-2-3-18(12-22)16-34-25-15-28-9-7-21(25)14-30-34/h5-11,13-15,18,22H,2-4,12,16H2,1H3,(H,31,35)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233413
PNG
(US9351965, 20)
Show SMILES O[C@]1(Cc2c(F)cccc2F)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4ncsc4c3)c2c1
Show InChI InChI=1S/C28H24F2N4O2S/c29-21-4-1-5-22(30)20(21)14-28(36)10-2-3-18(13-28)32-27(35)17-7-8-23-19(11-17)26(34-33-23)16-6-9-24-25(12-16)37-15-31-24/h1,4-9,11-12,15,18,36H,2-3,10,13-14H2,(H,32,35)(H,33,34)/t18-,28-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233487
PNG
(US9351965, 94)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cc3ccccc3n2)C1
Show InChI InChI=1S/C28H28N6O2/c1-18-13-19(10-12-29-18)26-23-14-20(8-9-25(23)31-32-26)27(35)30-22-6-4-11-28(36,15-22)17-34-16-21-5-2-3-7-24(21)33-34/h2-3,5,7-10,12-14,16,22,36H,4,6,11,15,17H2,1H3,(H,30,35)(H,31,32)/t22-,28+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233473
PNG
(US9351965, 80)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ncc3ccncc23)C1
Show InChI InChI=1S/C27H27N7O2/c1-17-11-18(7-10-29-17)25-22-12-19(4-5-23(22)32-33-25)26(35)31-21-3-2-8-27(36,13-21)16-34-24-15-28-9-6-20(24)14-30-34/h4-7,9-12,14-15,21,36H,2-3,8,13,16H2,1H3,(H,31,35)(H,32,33)/t21-,27+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233514
PNG
(US9351965, 121)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2c3ccccc3ccc2=O)C1
Show InChI InChI=1S/C30H29N5O2/c1-19-15-22(13-14-31-19)29-25-17-23(9-11-26(25)33-34-29)30(37)32-24-7-4-5-20(16-24)18-35-27-8-3-2-6-21(27)10-12-28(35)36/h2-3,6,8-15,17,20,24H,4-5,7,16,18H2,1H3,(H,32,37)(H,33,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233450
PNG
(US9351965, 57)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ccnc2)C1
Show InChI InChI=1S/C26H27N7O2/c1-32-14-19-11-17(4-6-22(19)31-32)24-21-12-18(5-7-23(21)29-30-24)25(34)28-20-3-2-8-26(35,13-20)15-33-10-9-27-16-33/h4-7,9-12,14,16,20,35H,2-3,8,13,15H2,1H3,(H,28,34)(H,29,30)/t20-,26+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233422
PNG
(BDBM233428 | US9351965, 29 | US9351965, 30 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1Cl
Show InChI InChI=1S/C26H25ClN4O2/c1-16-13-17(11-12-28-16)25-21-14-18(9-10-23(21)30-31-25)26(32)29-19-5-4-6-20(15-19)33-24-8-3-2-7-22(24)27/h2-3,7-14,19-20H,4-6,15H2,1H3,(H,29,32)(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233429
PNG
(US9351965, 140 | US9351965, 141 | US9351965, 36)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1Cl
Show InChI InChI=1S/C25H24ClN5O2/c1-16-13-17(10-11-27-16)24-20-14-18(8-9-22(20)28-29-24)25(32)30-31-12-4-5-19(15-31)33-23-7-3-2-6-21(23)26/h2-3,6-11,13-14,19H,4-5,12,15H2,1H3,(H,28,29)(H,30,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233410
PNG
(US9351965, 17)
Show SMILES CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2ccccc2F)C1
Show InChI InChI=1S/C29H31FN4O3/c1-18(2)37-26-12-10-21(17-31-26)27-23-14-19(9-11-25(23)33-34-27)28(35)32-22-7-5-13-29(36,16-22)15-20-6-3-4-8-24(20)30/h3-4,6,8-12,14,17-18,22,36H,5,7,13,15-16H2,1-2H3,(H,32,35)(H,33,34)/t22-,29+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233442
PNG
(US9351965, 49 | US9351965, 50 | US9351965, 51 | US...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(O)c1ccccc1
Show InChI InChI=1S/C27H28N4O3/c1-17-14-19(11-13-28-17)24-22-15-20(9-10-23(22)30-31-24)26(33)29-21-8-5-12-27(34,16-21)25(32)18-6-3-2-4-7-18/h2-4,6-7,9-11,13-15,21,25,32,34H,5,8,12,16H2,1H3,(H,29,33)(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233402
PNG
(US9351965, 9)
Show SMILES OC1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1
Show InChI InChI=1S/C28H26FN5O2/c29-23-6-2-1-4-19(23)15-28(36)11-3-5-21(16-28)31-27(35)18-7-9-24-22(14-18)26(33-32-24)20-8-10-25-30-12-13-34(25)17-20/h1-2,4,6-10,12-14,17,21,36H,3,5,11,15-16H2,(H,31,35)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233462
PNG
(US9351965, 69)
Show SMILES Cc1nc2ccccc2n1C[C@]1(O)CCC[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1S/C29H30N6O2/c1-18-14-20(11-13-30-18)27-23-15-21(9-10-24(23)33-34-27)28(36)32-22-6-5-12-29(37,16-22)17-35-19(2)31-25-7-3-4-8-26(25)35/h3-4,7-11,13-15,22,37H,5-6,12,16-17H2,1-2H3,(H,32,36)(H,33,34)/t22-,29-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233519
PNG
(US9351965, 126)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3cccc(F)c23)C1
Show InChI InChI=1S/C28H27FN6O/c1-17-12-19(10-11-30-17)26-23-14-20(8-9-25(23)33-34-26)28(36)32-22-6-2-4-18(13-22)16-35-27-21(15-31-35)5-3-7-24(27)29/h3,5,7-12,14-15,18,22H,2,4,6,13,16H2,1H3,(H,32,36)(H,33,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233511
PNG
(US9351965, 118)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cnc3cccnc23)C1
Show InChI InChI=1S/C27H27N7O/c1-17-12-19(9-11-28-17)25-22-14-20(7-8-23(22)32-33-25)27(35)31-21-5-2-4-18(13-21)15-34-16-30-24-6-3-10-29-26(24)34/h3,6-12,14,16,18,21H,2,4-5,13,15H2,1H3,(H,31,35)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233420
PNG
(US9351965, 27 | US9351965, 28 | US9351965, 33)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1F
Show InChI InChI=1S/C26H25FN4O2/c1-16-13-17(11-12-28-16)25-21-14-18(9-10-23(21)30-31-25)26(32)29-19-5-4-6-20(15-19)33-24-8-3-2-7-22(24)27/h2-3,7-14,19-20H,4-6,15H2,1H3,(H,29,32)(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233451
PNG
(US9351965, 58)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2ccnc2)C1
Show InChI InChI=1S/C26H27N7O2/c1-32-14-19-11-17(4-6-22(19)31-32)24-21-12-18(5-7-23(21)29-30-24)25(34)28-20-3-2-8-26(35,13-20)15-33-10-9-27-16-33/h4-7,9-12,14,16,20,35H,2-3,8,13,15H2,1H3,(H,28,34)(H,29,30)/t20-,26-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233531
PNG
(US9351965, 138 | US9351965, 139)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCC(CO)(Cc2ccccc2F)C1
Show InChI InChI=1S/C27H27FN4O2/c1-17-12-18(9-11-29-17)25-22-13-19(6-7-24(22)31-32-25)26(34)30-21-8-10-27(15-21,16-33)14-20-4-2-3-5-23(20)28/h2-7,9,11-13,21,33H,8,10,14-16H2,1H3,(H,30,34)(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233452
PNG
(US9351965, 59)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cccn2)C1
Show InChI InChI=1S/C26H27N7O2/c1-32-15-19-12-17(5-7-22(19)31-32)24-21-13-18(6-8-23(21)29-30-24)25(34)28-20-4-2-9-26(35,14-20)16-33-11-3-10-27-33/h3,5-8,10-13,15,20,35H,2,4,9,14,16H2,1H3,(H,28,34)(H,29,30)/t20-,26-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233497
PNG
(US9351965, 104)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2ncc3cccc(F)c23)C1
Show InChI InChI=1S/C28H27FN6O2/c1-17-12-18(9-11-30-17)25-22-13-19(7-8-24(22)33-34-25)27(36)32-21-5-3-10-28(37,14-21)16-35-26-20(15-31-35)4-2-6-23(26)29/h2,4,6-9,11-13,15,21,37H,3,5,10,14,16H2,1H3,(H,32,36)(H,33,34)/t21-,28-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233503
PNG
(US9351965, 110)
Show SMILES O=C(NC1CCCC(Cn2cccn2)C1)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1
Show InChI InChI=1S/C25H25N7O/c33-25(28-20-4-1-3-17(13-20)15-32-11-2-9-27-32)18-5-7-22-21(14-18)24(30-29-22)19-6-8-23-26-10-12-31(23)16-19/h2,5-12,14,16-17,20H,1,3-4,13,15H2,(H,28,33)(H,29,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233504
PNG
(US9351965, 111)
Show SMILES O=C(NC1CCCC(Cn2cncn2)C1)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1
Show InChI InChI=1S/C24H24N8O/c33-24(28-19-3-1-2-16(10-19)12-32-15-25-14-27-32)17-4-6-21-20(11-17)23(30-29-21)18-5-7-22-26-8-9-31(22)13-18/h4-9,11,13-16,19H,1-3,10,12H2,(H,28,33)(H,29,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233419
PNG
(US9351965, 26)
Show SMILES COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc(OC(C)C)cc3)c2c1
Show InChI InChI=1S/C31H34FN3O4/c1-19(2)39-23-12-9-20(10-13-23)29-24-16-21(11-14-27(24)34-35-29)30(36)33-22-6-5-15-31(37,17-22)18-25-26(32)7-4-8-28(25)38-3/h4,7-14,16,19,22,37H,5-6,15,17-18H2,1-3H3,(H,33,36)(H,34,35)/t22-,31-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233429
PNG
(US9351965, 140 | US9351965, 141 | US9351965, 36)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1Cl
Show InChI InChI=1S/C25H24ClN5O2/c1-16-13-17(10-11-27-16)24-20-14-18(8-9-22(20)28-29-24)25(32)30-31-12-4-5-19(15-31)33-23-7-3-2-6-21(23)26/h2-3,6-11,13-14,19H,4-5,12,15H2,1H3,(H,28,29)(H,30,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233510
PNG
(US9351965, 117)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cnc3ncccc23)C1
Show InChI InChI=1S/C27H27N7O/c1-17-12-19(9-11-28-17)25-22-14-20(7-8-23(22)32-33-25)27(35)31-21-5-2-4-18(13-21)15-34-16-30-26-24(34)6-3-10-29-26/h3,6-12,14,16,18,21H,2,4-5,13,15H2,1H3,(H,31,35)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233475
PNG
(US9351965, 82)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cnc3cccnc23)C1
Show InChI InChI=1S/C27H27N7O2/c1-17-12-18(8-11-28-17)24-21-13-19(6-7-22(21)32-33-24)26(35)31-20-4-2-9-27(36,14-20)15-34-16-30-23-5-3-10-29-25(23)34/h3,5-8,10-13,16,20,36H,2,4,9,14-15H2,1H3,(H,31,35)(H,32,33)/t20-,27+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233434
PNG
(US9351965, 41)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(C1)Oc1ccccc1
Show InChI InChI=1S/C27H28N4O3/c1-18-14-19(11-13-28-18)25-23-15-20(9-10-24(23)30-31-25)26(33)29-21-6-5-12-27(16-21,17-32)34-22-7-3-2-4-8-22/h2-4,7-11,13-15,21,32H,5-6,12,16-17H2,1H3,(H,29,33)(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233457
PNG
(US9351965, 64)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cncn2)C1
Show InChI InChI=1S/C23H25N7O2/c1-15-9-16(6-8-25-15)21-19-10-17(4-5-20(19)28-29-21)22(31)27-18-3-2-7-23(32,11-18)12-30-14-24-13-26-30/h4-6,8-10,13-14,18,32H,2-3,7,11-12H2,1H3,(H,27,31)(H,28,29)/t18-,23+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233439
PNG
(US9351965, 46 | US9351965, 48)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(F)(F)c1ccccc1
Show InChI InChI=1S/C27H26F2N4O2/c1-17-14-18(11-13-30-17)24-22-15-19(9-10-23(22)32-33-24)25(34)31-21-8-5-12-26(35,16-21)27(28,29)20-6-3-2-4-7-20/h2-4,6-7,9-11,13-15,21,35H,5,8,12,16H2,1H3,(H,31,34)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233499
PNG
(US9351965, 106)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@](O)(Cn2ncc3ccc(cc23)C(F)(F)F)C1
Show InChI InChI=1S/C29H27F3N6O2/c1-17-11-18(8-10-33-17)26-23-12-19(5-7-24(23)36-37-26)27(39)35-22-3-2-9-28(40,14-22)16-38-25-13-21(29(30,31)32)6-4-20(25)15-34-38/h4-8,10-13,15,22,40H,2-3,9,14,16H2,1H3,(H,35,39)(H,36,37)/t22-,28+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233523
PNG
(US9351965, 130 | US9351965, 133)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2ccccc2F)C1
Show InChI InChI=1S/C28H29FN4O2/c1-18-13-19(10-12-30-18)26-23-14-20(8-9-25(23)32-33-26)27(35)31-22-6-4-11-28(16-22,17-34)15-21-5-2-3-7-24(21)29/h2-3,5,7-10,12-14,22,34H,4,6,11,15-17H2,1H3,(H,31,35)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233420
PNG
(US9351965, 27 | US9351965, 28 | US9351965, 33)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1F
Show InChI InChI=1S/C26H25FN4O2/c1-16-13-17(11-12-28-16)25-21-14-18(9-10-23(21)30-31-25)26(32)29-19-5-4-6-20(15-19)33-24-8-3-2-7-22(24)27/h2-3,7-14,19-20H,4-6,15H2,1H3,(H,29,32)(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233420
PNG
(US9351965, 27 | US9351965, 28 | US9351965, 33)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1F
Show InChI InChI=1S/C26H25FN4O2/c1-16-13-17(11-12-28-16)25-21-14-18(9-10-23(21)30-31-25)26(32)29-19-5-4-6-20(15-19)33-24-8-3-2-7-22(24)27/h2-3,7-14,19-20H,4-6,15H2,1H3,(H,29,32)(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233394
PNG
(US9351965, 1 | US9351965, 2 | US9351965, 3 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2ccccc2F)C1
Show InChI InChI=1S/C27H27FN4O2/c1-17-13-18(10-12-29-17)25-22-14-19(8-9-24(22)31-32-25)26(33)30-21-6-4-11-27(34,16-21)15-20-5-2-3-7-23(20)28/h2-3,5,7-10,12-14,21,34H,4,6,11,15-16H2,1H3,(H,30,33)(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233430
PNG
(US9351965, 37 | US9351965, 38)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C26H24F2N4O2/c1-15-11-16(9-10-29-15)25-21-12-17(5-7-23(21)31-32-25)26(33)30-19-3-2-4-20(14-19)34-24-8-6-18(27)13-22(24)28/h5-13,19-20H,2-4,14H2,1H3,(H,30,33)(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233469
PNG
(US9351965, 76)
Show SMILES Cc1nc2cnccc2n1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1S/C28H29N7O2/c1-17-12-19(7-11-30-17)26-22-13-20(5-6-23(22)33-34-26)27(36)32-21-4-3-9-28(37,14-21)16-35-18(2)31-24-15-29-10-8-25(24)35/h5-8,10-13,15,21,37H,3-4,9,14,16H2,1-2H3,(H,32,36)(H,33,34)/t21-,28-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233411
PNG
(US9351965, 18)
Show SMILES CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2c(F)cccc2F)C1
Show InChI InChI=1S/C29H30F2N4O3/c1-17(2)38-26-11-9-19(16-32-26)27-21-13-18(8-10-25(21)34-35-27)28(36)33-20-5-4-12-29(37,14-20)15-22-23(30)6-3-7-24(22)31/h3,6-11,13,16-17,20,37H,4-5,12,14-15H2,1-2H3,(H,33,36)(H,34,35)/t20-,29-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233453
PNG
(US9351965, 60)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cccn2)C1
Show InChI InChI=1S/C26H27N7O2/c1-32-15-19-12-17(5-7-22(19)31-32)24-21-13-18(6-8-23(21)29-30-24)25(34)28-20-4-2-9-26(35,14-20)16-33-11-3-10-27-33/h3,5-8,10-13,15,20,35H,2,4,9,14,16H2,1H3,(H,28,34)(H,29,30)/t20-,26+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233535
PNG
(US9351965, 142 | US9351965, 143)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1F
Show InChI InChI=1S/C25H24FN5O2/c1-16-13-17(10-11-27-16)24-20-14-18(8-9-22(20)28-29-24)25(32)30-31-12-4-5-19(15-31)33-23-7-3-2-6-21(23)26/h2-3,6-11,13-14,19H,4-5,12,15H2,1H3,(H,28,29)(H,30,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233546
PNG
(US9351965, 153)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cc2ccccc2F)(C1)NC=O
Show InChI InChI=1S/C28H28FN5O2/c1-18-13-19(10-12-30-18)26-23-14-20(8-9-25(23)33-34-26)27(36)32-22-6-4-11-28(16-22,31-17-35)15-21-5-2-3-7-24(21)29/h2-3,5,7-10,12-14,17,22H,4,6,11,15-16H2,1H3,(H,31,35)(H,32,36)(H,33,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233506
PNG
(US9351965, 113)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cc3cccnc3n2)C1
Show InChI InChI=1S/C27H27N7O/c1-17-12-19(9-11-28-17)25-23-14-20(7-8-24(23)31-32-25)27(35)30-22-6-2-4-18(13-22)15-34-16-21-5-3-10-29-26(21)33-34/h3,5,7-12,14,16,18,22H,2,4,6,13,15H2,1H3,(H,30,35)(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233486
PNG
(US9351965, 93)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2c3ccccc3ccc2=O)C1
Show InChI InChI=1S/C30H29N5O3/c1-19-15-21(12-14-31-19)28-24-16-22(8-10-25(24)33-34-28)29(37)32-23-6-4-13-30(38,17-23)18-35-26-7-3-2-5-20(26)9-11-27(35)36/h2-3,5,7-12,14-16,23,38H,4,6,13,17-18H2,1H3,(H,32,37)(H,33,34)/t23-,30+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233436
PNG
(US9351965, 43 | US9351965, 44 | US9351965, 45)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(C1)Oc1cccc(F)c1
Show InChI InChI=1S/C27H27FN4O3/c1-17-12-18(9-11-29-17)25-23-13-19(7-8-24(23)31-32-25)26(34)30-21-5-3-10-27(15-21,16-33)35-22-6-2-4-20(28)14-22/h2,4,6-9,11-14,21,33H,3,5,10,15-16H2,1H3,(H,30,34)(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233422
PNG
(BDBM233428 | US9351965, 29 | US9351965, 30 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1Cl
Show InChI InChI=1S/C26H25ClN4O2/c1-16-13-17(11-12-28-16)25-21-14-18(9-10-23(21)30-31-25)26(32)29-19-5-4-6-20(15-19)33-24-8-3-2-7-22(24)27/h2-3,7-14,19-20H,4-6,15H2,1H3,(H,29,32)(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233544
PNG
(US9351965, 151)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(CO)(Cc2ccccc2F)C1
Show InChI InChI=1S/C27H28FN5O2/c1-18-13-19(9-11-29-18)25-22-14-20(7-8-24(22)30-31-25)26(35)32-33-12-4-10-27(16-33,17-34)15-21-5-2-3-6-23(21)28/h2-3,5-9,11,13-14,34H,4,10,12,15-17H2,1H3,(H,30,31)(H,32,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233456
PNG
(US9351965, 63)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cncn2)C1
Show InChI InChI=1S/C23H25N7O2/c1-15-9-16(6-8-25-15)21-19-10-17(4-5-20(19)28-29-21)22(31)27-18-3-2-7-23(32,11-18)12-30-14-24-13-26-30/h4-6,8-10,13-14,18,32H,2-3,7,11-12H2,1H3,(H,27,31)(H,28,29)/t18-,23-/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233422
PNG
(BDBM233428 | US9351965, 29 | US9351965, 30 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1Cl
Show InChI InChI=1S/C26H25ClN4O2/c1-16-13-17(11-12-28-16)25-21-14-18(9-10-23(21)30-31-25)26(32)29-19-5-4-6-20(15-19)33-24-8-3-2-7-22(24)27/h2-3,7-14,19-20H,4-6,15H2,1H3,(H,29,32)(H,30,31)
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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233442
PNG
(US9351965, 49 | US9351965, 50 | US9351965, 51 | US...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(O)c1ccccc1
Show InChI InChI=1S/C27H28N4O3/c1-17-14-19(11-13-28-17)24-22-15-20(9-10-23(22)30-31-24)26(33)29-21-8-5-12-27(34,16-21)25(32)18-6-3-2-4-7-18/h2-4,6-7,9-11,13-15,21,25,32,34H,5,8,12,16H2,1H3,(H,29,33)(H,30,31)
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233432
PNG
(US9351965, 39 | US9351965, 40)
Show SMILES COC1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1S/C28H29FN4O2/c1-18-14-19(11-13-30-18)26-23-15-20(9-10-25(23)32-33-26)27(34)31-22-7-5-12-28(17-22,35-2)16-21-6-3-4-8-24(21)29/h3-4,6,8-11,13-15,22H,5,7,12,16-17H2,1-2H3,(H,31,34)(H,32,33)
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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233436
PNG
(US9351965, 43 | US9351965, 44 | US9351965, 45)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(C1)Oc1cccc(F)c1
Show InChI InChI=1S/C27H27FN4O3/c1-17-12-18(9-11-29-17)25-23-13-19(7-8-24(23)31-32-25)26(34)30-21-5-3-10-27(15-21,16-33)35-22-6-2-4-20(28)14-22/h2,4,6-9,11-14,21,33H,3,5,10,15-16H2,1H3,(H,30,34)(H,31,32)
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233525
PNG
(US9351965, 132)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2ccccc2)C1
Show InChI InChI=1S/C28H30N4O2/c1-19-14-21(11-13-29-19)26-24-15-22(9-10-25(24)31-32-26)27(34)30-23-8-5-12-28(17-23,18-33)16-20-6-3-2-4-7-20/h2-4,6-7,9-11,13-15,23,33H,5,8,12,16-18H2,1H3,(H,30,34)(H,31,32)
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233440
PNG
(US9351965, 47 | US9351965, 53)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(=O)c1ccccc1
Show InChI InChI=1S/C27H26N4O3/c1-17-14-19(11-13-28-17)24-22-15-20(9-10-23(22)30-31-24)26(33)29-21-8-5-12-27(34,16-21)25(32)18-6-3-2-4-7-18/h2-4,6-7,9-11,13-15,21,34H,5,8,12,16H2,1H3,(H,29,33)(H,30,31)
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233517
PNG
(US9351965, 124)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cc3cc(F)ccc3n2)C1
Show InChI InChI=1S/C28H27FN6O/c1-17-11-19(9-10-30-17)27-24-14-20(5-7-26(24)32-33-27)28(36)31-23-4-2-3-18(12-23)15-35-16-21-13-22(29)6-8-25(21)34-35/h5-11,13-14,16,18,23H,2-4,12,15H2,1H3,(H,31,36)(H,32,33)
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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233403
PNG
(US9351965, 10 | US9351965, 11)
Show SMILES OC1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4ncsc4c3)c2c1
Show InChI InChI=1S/C28H25FN4O2S/c29-22-6-2-1-4-19(22)14-28(35)11-3-5-20(15-28)31-27(34)18-8-9-23-21(12-18)26(33-32-23)17-7-10-24-25(13-17)36-16-30-24/h1-2,4,6-10,12-13,16,20,35H,3,5,11,14-15H2,(H,31,34)(H,32,33)
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233442
PNG
(US9351965, 49 | US9351965, 50 | US9351965, 51 | US...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(O)c1ccccc1
Show InChI InChI=1S/C27H28N4O3/c1-17-14-19(11-13-28-17)24-22-15-20(9-10-23(22)30-31-24)26(33)29-21-8-5-12-27(34,16-21)25(32)18-6-3-2-4-7-18/h2-4,6-7,9-11,13-15,21,25,32,34H,5,8,12,16H2,1H3,(H,29,33)(H,30,31)
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233409
PNG
(US9351965, 16)
Show SMILES CC(C)Oc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2ccccc2F)C1
Show InChI InChI=1S/C29H31FN4O3/c1-18(2)37-26-15-19(11-13-31-26)27-23-14-20(9-10-25(23)33-34-27)28(35)32-22-7-5-12-29(36,17-22)16-21-6-3-4-8-24(21)30/h3-4,6,8-11,13-15,18,22,36H,5,7,12,16-17H2,1-2H3,(H,32,35)(H,33,34)/t22-,29+/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233529
PNG
(US9351965, 136)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cc2ccc(F)cc2)(C1)C(O)=O
Show InChI InChI=1S/C28H27FN4O3/c1-17-13-19(10-12-30-17)25-23-14-20(6-9-24(23)32-33-25)26(34)31-22-3-2-11-28(16-22,27(35)36)15-18-4-7-21(29)8-5-18/h4-10,12-14,22H,2-3,11,15-16H2,1H3,(H,31,34)(H,32,33)(H,35,36)
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233463
PNG
(US9351965, 70)
Show SMILES Cc1nc2ccccc2n1C[C@@]1(O)CCC[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1S/C29H30N6O2/c1-18-14-20(11-13-30-18)27-23-15-21(9-10-24(23)33-34-27)28(36)32-22-6-5-12-29(37,16-22)17-35-19(2)31-25-7-3-4-8-26(25)35/h3-4,7-11,13-15,22,37H,5-6,12,16-17H2,1-2H3,(H,32,36)(H,33,34)/t22-,29+/m0/s1
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233418
PNG
(US9351965, 25)
Show SMILES COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(OC(C)C)c3)c2c1
Show InChI InChI=1S/C30H33FN4O4/c1-18(2)39-27-15-19(11-13-32-27)28-22-14-20(9-10-25(22)34-35-28)29(36)33-21-6-5-12-30(37,16-21)17-23-24(31)7-4-8-26(23)38-3/h4,7-11,13-15,18,21,37H,5-6,12,16-17H2,1-3H3,(H,33,36)(H,34,35)/t21-,30-/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233528
PNG
(US9351965, 135)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2ccc(F)cc2)C1
Show InChI InChI=1S/C28H29FN4O2/c1-18-13-20(10-12-30-18)26-24-14-21(6-9-25(24)32-33-26)27(35)31-23-3-2-11-28(16-23,17-34)15-19-4-7-22(29)8-5-19/h4-10,12-14,23,34H,2-3,11,15-17H2,1H3,(H,31,35)(H,32,33)
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233500
PNG
(US9351965, 107)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@](O)(Cn2ncc3ccc(F)cc23)C1
Show InChI InChI=1S/C28H27FN6O2/c1-17-11-18(8-10-30-17)26-23-12-19(5-7-24(23)33-34-26)27(36)32-22-3-2-9-28(37,14-22)16-35-25-13-21(29)6-4-20(25)15-31-35/h4-8,10-13,15,22,37H,2-3,9,14,16H2,1H3,(H,32,36)(H,33,34)/t22-,28+/m0/s1
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233540
PNG
(US9351965, 147)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(CO)(C1)Oc1cc(F)ccc1F
Show InChI InChI=1S/C26H25F2N5O3/c1-16-11-17(7-9-29-16)24-20-12-18(3-6-22(20)30-31-24)25(35)32-33-10-2-8-26(14-33,15-34)36-23-13-19(27)4-5-21(23)28/h3-7,9,11-13,34H,2,8,10,14-15H2,1H3,(H,30,31)(H,32,35)
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233466
PNG
(US9351965, 73 | US9351965, 75)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cc3cccnc3n2)C1
Show InChI InChI=1S/C27H27N7O2/c1-17-12-18(8-11-28-17)24-22-13-19(6-7-23(22)31-32-24)26(35)30-21-5-2-9-27(36,14-21)16-34-15-20-4-3-10-29-25(20)33-34/h3-4,6-8,10-13,15,21,36H,2,5,9,14,16H2,1H3,(H,30,35)(H,31,32)/t21-,27-/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233480
PNG
(US9351965, 87)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2ncc3cnccc23)C1
Show InChI InChI=1S/C27H27N7O2/c1-17-11-18(6-10-29-17)25-22-12-19(4-5-23(22)32-33-25)26(35)31-21-3-2-8-27(36,13-21)16-34-24-7-9-28-14-20(24)15-30-34/h4-7,9-12,14-15,21,36H,2-3,8,13,16H2,1H3,(H,31,35)(H,32,33)/t21-,27-/m1/s1
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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233460
PNG
(US9351965, 67)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2c(nc3ccccc23)C(F)(F)F)C1
Show InChI InChI=1S/C29H27F3N6O2/c1-17-13-18(10-12-33-17)25-21-14-19(8-9-22(21)36-37-25)26(39)34-20-5-4-11-28(40,15-20)16-38-24-7-3-2-6-23(24)35-27(38)29(30,31)32/h2-3,6-10,12-14,20,40H,4-5,11,15-16H2,1H3,(H,34,39)(H,36,37)/t20-,28-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233527
PNG
(US9351965, 134)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2ccc(F)cc2F)C1
Show InChI InChI=1S/C28H28F2N4O2/c1-17-11-18(8-10-31-17)26-23-12-19(5-7-25(23)33-34-26)27(36)32-22-3-2-9-28(15-22,16-35)14-20-4-6-21(29)13-24(20)30/h4-8,10-13,22,35H,2-3,9,14-16H2,1H3,(H,32,36)(H,33,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233522
PNG
(US9351965, 129 | US9351965, 137)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2c(F)cccc2F)C1
Show InChI InChI=1S/C28H28F2N4O2/c1-17-12-18(9-11-31-17)26-21-13-19(7-8-25(21)33-34-26)27(36)32-20-4-3-10-28(14-20,16-35)15-22-23(29)5-2-6-24(22)30/h2,5-9,11-13,20,35H,3-4,10,14-16H2,1H3,(H,32,36)(H,33,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233541
PNG
(US9351965, 148)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(CO)(C1)Oc1ccc(F)cc1
Show InChI InChI=1S/C26H26FN5O3/c1-17-13-18(9-11-28-17)24-22-14-19(3-8-23(22)29-30-24)25(34)31-32-12-2-10-26(15-32,16-33)35-21-6-4-20(27)5-7-21/h3-9,11,13-14,33H,2,10,12,15-16H2,1H3,(H,29,30)(H,31,34)
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233464
PNG
(US9351965, 71)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cnc3ncccc23)C1
Show InChI InChI=1S/C27H27N7O2/c1-17-12-18(8-11-28-17)24-21-13-19(6-7-22(21)32-33-24)26(35)31-20-4-2-9-27(36,14-20)15-34-16-30-25-23(34)5-3-10-29-25/h3,5-8,10-13,16,20,36H,2,4,9,14-15H2,1H3,(H,31,35)(H,32,33)/t20-,27-/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233424
PNG
(US9351965, 31)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1c(C)cccc1C
Show InChI InChI=1S/C28H30N4O2/c1-17-6-4-7-18(2)27(17)34-23-9-5-8-22(16-23)30-28(33)21-10-11-25-24(15-21)26(32-31-25)20-12-13-29-19(3)14-20/h4,6-7,10-15,22-23H,5,8-9,16H2,1-3H3,(H,30,33)(H,31,32)
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233430
PNG
(US9351965, 37 | US9351965, 38)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C26H24F2N4O2/c1-15-11-16(9-10-29-15)25-21-12-17(5-7-23(21)31-32-25)26(33)30-19-3-2-4-20(14-19)34-24-8-6-18(27)13-22(24)28/h5-13,19-20H,2-4,14H2,1H3,(H,30,33)(H,31,32)
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233537
PNG
(US9351965, 144)
Show SMILES CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC1CCc1ccccc1
Show InChI InChI=1S/C28H31N5O2/c1-19(2)35-26-15-12-22(18-29-26)27-24-17-21(11-14-25(24)30-31-27)28(34)32-33-16-6-9-23(33)13-10-20-7-4-3-5-8-20/h3-5,7-8,11-12,14-15,17-19,23H,6,9-10,13,16H2,1-2H3,(H,30,31)(H,32,34)
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233481
PNG
(US9351965, 88)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(CN2C(=O)Cc3ccccc23)C1
Show InChI InChI=1S/C29H29N5O3/c1-18-13-20(10-12-30-18)27-23-14-21(8-9-24(23)32-33-27)28(36)31-22-6-4-11-29(37,16-22)17-34-25-7-3-2-5-19(25)15-26(34)35/h2-3,5,7-10,12-14,22,37H,4,6,11,15-17H2,1H3,(H,31,36)(H,32,33)/t22-,29-/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233545
PNG
(US9351965, 152)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(N)(Cc2ccccc2F)C1
Show InChI InChI=1S/C27H28FN5O/c1-17-13-18(10-12-30-17)25-22-14-19(8-9-24(22)32-33-25)26(34)31-21-6-4-11-27(29,16-21)15-20-5-2-3-7-23(20)28/h2-3,5,7-10,12-14,21H,4,6,11,15-16,29H2,1H3,(H,31,34)(H,32,33)
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Merck Sharp & Dohme Corp.

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Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233512
PNG
(US9351965, 119)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3cnccc23)C1
Show InChI InChI=1S/C27H27N7O/c1-17-11-19(7-10-29-17)26-23-13-20(5-6-24(23)32-33-26)27(35)31-22-4-2-3-18(12-22)16-34-25-8-9-28-14-21(25)15-30-34/h5-11,13-15,18,22H,2-4,12,16H2,1H3,(H,31,35)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233465
PNG
(US9351965, 72)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cnc3cccnc23)C1
Show InChI InChI=1S/C27H27N7O2/c1-17-12-18(8-11-28-17)24-21-13-19(6-7-22(21)32-33-24)26(35)31-20-4-2-9-27(36,14-20)15-34-16-30-23-5-3-10-29-25(23)34/h3,5-8,10-13,16,20,36H,2,4,9,14-15H2,1H3,(H,31,35)(H,32,33)/t20-,27-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233484
PNG
(US9351965, 91)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ncc3cnccc23)C1
Show InChI InChI=1S/C27H27N7O2/c1-17-11-18(6-10-29-17)25-22-12-19(4-5-23(22)32-33-25)26(35)31-21-3-2-8-27(36,13-21)16-34-24-7-9-28-14-20(24)15-30-34/h4-7,9-12,14-15,21,36H,2-3,8,13,16H2,1H3,(H,31,35)(H,32,33)/t21-,27+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233425
PNG
(US9351965, 32)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1c(F)cccc1F
Show InChI InChI=1S/C26H24F2N4O2/c1-15-12-16(10-11-29-15)24-20-13-17(8-9-23(20)31-32-24)26(33)30-18-4-2-5-19(14-18)34-25-21(27)6-3-7-22(25)28/h3,6-13,18-19H,2,4-5,14H2,1H3,(H,30,33)(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233489
PNG
(US9351965, 96)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2ncc3c(F)cccc23)C1
Show InChI InChI=1S/C28H27FN6O2/c1-17-12-18(9-11-30-17)26-21-13-19(7-8-24(21)33-34-26)27(36)32-20-4-3-10-28(37,14-20)16-35-25-6-2-5-23(29)22(25)15-31-35/h2,5-9,11-13,15,20,37H,3-4,10,14,16H2,1H3,(H,32,36)(H,33,34)/t20-,28-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233440
PNG
(US9351965, 47 | US9351965, 53)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(=O)c1ccccc1
Show InChI InChI=1S/C27H26N4O3/c1-17-14-19(11-13-28-17)24-22-15-20(9-10-23(22)30-31-24)26(33)29-21-8-5-12-27(34,16-21)25(32)18-6-3-2-4-7-18/h2-4,6-7,9-11,13-15,21,34H,5,8,12,16H2,1H3,(H,29,33)(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233394
PNG
(US9351965, 1 | US9351965, 2 | US9351965, 3 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2ccccc2F)C1
Show InChI InChI=1S/C27H27FN4O2/c1-17-13-18(10-12-29-17)25-22-14-19(8-9-24(22)31-32-25)26(33)30-21-6-4-11-27(34,16-21)15-20-5-2-3-7-23(20)28/h2-3,5,7-10,12-14,21,34H,4,6,11,15-16H2,1H3,(H,30,33)(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233471
PNG
(US9351965, 78)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cc3cccnc3n2)C1
Show InChI InChI=1S/C27H27N7O2/c1-17-12-18(8-11-28-17)24-22-13-19(6-7-23(22)31-32-24)26(35)30-21-5-2-9-27(36,14-21)16-34-15-20-4-3-10-29-25(20)33-34/h3-4,6-8,10-13,15,21,36H,2,5,9,14,16H2,1H3,(H,30,35)(H,31,32)/t21-,27+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233466
PNG
(US9351965, 73 | US9351965, 75)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cc3cccnc3n2)C1
Show InChI InChI=1S/C27H27N7O2/c1-17-12-18(8-11-28-17)24-22-13-19(6-7-23(22)31-32-24)26(35)30-21-5-2-9-27(36,14-21)16-34-15-20-4-3-10-29-25(20)33-34/h3-4,6-8,10-13,15,21,36H,2,5,9,14,16H2,1H3,(H,30,35)(H,31,32)/t21-,27-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233439
PNG
(US9351965, 46 | US9351965, 48)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(F)(F)c1ccccc1
Show InChI InChI=1S/C27H26F2N4O2/c1-17-14-18(11-13-30-17)24-22-15-19(9-10-23(22)32-33-24)25(34)31-21-8-5-12-26(35,16-21)27(28,29)20-6-3-2-4-7-20/h2-4,6-7,9-11,13-15,21,35H,5,8,12,16H2,1H3,(H,31,34)(H,32,33)
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US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233522
PNG
(US9351965, 129 | US9351965, 137)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2c(F)cccc2F)C1
Show InChI InChI=1S/C28H28F2N4O2/c1-17-12-18(9-11-31-17)26-21-13-19(7-8-25(21)33-34-26)27(36)32-20-4-3-10-28(14-20,16-35)15-22-23(29)5-2-6-24(22)30/h2,5-9,11-13,20,35H,3-4,10,14-16H2,1H3,(H,32,36)(H,33,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233495
PNG
(US9351965, 102)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc3cccc(F)c3n2)C1
Show InChI InChI=1S/C28H27FN6O2/c1-17-12-18(9-11-30-17)25-22-13-19(7-8-24(22)32-33-25)27(36)31-21-5-3-10-28(37,14-21)16-35-15-20-4-2-6-23(29)26(20)34-35/h2,4,6-9,11-13,15,21,37H,3,5,10,14,16H2,1H3,(H,31,36)(H,32,33)/t21-,28-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233482
PNG
(US9351965, 89)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2c3ccccc3ccc2=O)C1
Show InChI InChI=1S/C30H29N5O3/c1-19-15-21(12-14-31-19)28-24-16-22(8-10-25(24)33-34-28)29(37)32-23-6-4-13-30(38,17-23)18-35-26-7-3-2-5-20(26)9-11-27(35)36/h2-3,5,7-12,14-16,23,38H,4,6,13,17-18H2,1H3,(H,32,37)(H,33,34)/t23-,30-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233492
PNG
(US9351965, 101 | US9351965, 99)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc3cc(F)ccc3n2)C1
Show InChI InChI=1S/C28H27FN6O2/c1-17-11-18(8-10-30-17)26-23-13-19(4-6-25(23)32-33-26)27(36)31-22-3-2-9-28(37,14-22)16-35-15-20-12-21(29)5-7-24(20)34-35/h4-8,10-13,15,22,37H,2-3,9,14,16H2,1H3,(H,31,36)(H,32,33)/t22-,28-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233467
PNG
(US9351965, 74)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2ncc3ccncc23)C1
Show InChI InChI=1S/C27H27N7O2/c1-17-11-18(7-10-29-17)25-22-12-19(4-5-23(22)32-33-25)26(35)31-21-3-2-8-27(36,13-21)16-34-24-15-28-9-6-20(24)14-30-34/h4-7,9-12,14-15,21,36H,2-3,8,13,16H2,1H3,(H,31,35)(H,32,33)/t21-,27-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233461
PNG
(US9351965, 68)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2c(nc3ccccc23)C(F)(F)F)C1
Show InChI InChI=1S/C29H27F3N6O2/c1-17-13-18(10-12-33-17)25-21-14-19(8-9-22(21)36-37-25)26(39)34-20-5-4-11-28(40,15-20)16-38-24-7-3-2-6-23(24)35-27(38)29(30,31)32/h2-3,6-10,12-14,20,40H,4-5,11,15-16H2,1H3,(H,34,39)(H,36,37)/t20-,28+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233474
PNG
(US9351965, 81)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cnc3ncccc23)C1
Show InChI InChI=1S/C27H27N7O2/c1-17-12-18(8-11-28-17)24-21-13-19(6-7-22(21)32-33-24)26(35)31-20-4-2-9-27(36,14-20)15-34-16-30-25-23(34)5-3-10-29-25/h3,5-8,10-13,16,20,36H,2,4,9,14-15H2,1H3,(H,31,35)(H,32,33)/t20-,27+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233542
PNG
(US9351965, 149)
Show SMILES COCC1(Cc2ccccc2F)CCCN(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1S/C28H30FN5O2/c1-19-14-20(10-12-30-19)26-23-15-21(8-9-25(23)31-32-26)27(35)33-34-13-5-11-28(17-34,18-36-2)16-22-6-3-4-7-24(22)29/h3-4,6-10,12,14-15H,5,11,13,16-18H2,1-2H3,(H,31,32)(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233458
PNG
(US9351965, 65)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2ncc3ccccc23)C1
Show InChI InChI=1S/C28H28N6O2/c1-18-13-19(10-12-29-18)26-23-14-20(8-9-24(23)32-33-26)27(35)31-22-6-4-11-28(36,15-22)17-34-25-7-3-2-5-21(25)16-30-34/h2-3,5,7-10,12-14,16,22,36H,4,6,11,15,17H2,1H3,(H,31,35)(H,32,33)/t22-,28-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233470
PNG
(US9351965, 77)
Show SMILES Cc1nc2cnccc2n1C[C@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1S/C28H29N7O2/c1-17-12-19(7-11-30-17)26-22-13-20(5-6-23(22)33-34-26)27(36)32-21-4-3-9-28(37,14-21)16-35-18(2)31-24-15-29-10-8-25(24)35/h5-8,10-13,15,21,37H,3-4,9,14,16H2,1-2H3,(H,32,36)(H,33,34)/t21-,28+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233479
PNG
(US9351965, 86)
Show SMILES O[C@@]1(Cn2ncc3ncccc23)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1
Show InChI InChI=1S/C28H26N8O2/c37-27(32-20-3-1-9-28(38,14-20)17-36-24-4-2-10-29-23(24)15-31-36)18-5-7-22-21(13-18)26(34-33-22)19-6-8-25-30-11-12-35(25)16-19/h2,4-8,10-13,15-16,20,38H,1,3,9,14,17H2,(H,32,37)(H,33,34)/t20-,28+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233488
PNG
(US9351965, 95)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc(C#N)c3ccccc23)C1
Show InChI InChI=1S/C30H28N6O2/c1-19-13-20(10-12-32-19)28-25-14-21(8-9-26(25)34-35-28)29(37)33-23-5-4-11-30(38,15-23)18-36-17-22(16-31)24-6-2-3-7-27(24)36/h2-3,6-10,12-14,17,23,38H,4-5,11,15,18H2,1H3,(H,33,37)(H,34,35)/t23-,30-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233403
PNG
(US9351965, 10 | US9351965, 11)
Show SMILES OC1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4ncsc4c3)c2c1
Show InChI InChI=1S/C28H25FN4O2S/c29-22-6-2-1-4-19(22)14-28(35)11-3-5-20(15-28)31-27(34)18-8-9-23-21(12-18)26(33-32-23)17-7-10-24-25(13-17)36-16-30-24/h1-2,4,6-10,12-13,16,20,35H,3,5,11,14-15H2,(H,31,34)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233422
PNG
(BDBM233428 | US9351965, 29 | US9351965, 30 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1Cl
Show InChI InChI=1S/C26H25ClN4O2/c1-16-13-17(11-12-28-16)25-21-14-18(9-10-23(21)30-31-25)26(32)29-19-5-4-6-20(15-19)33-24-8-3-2-7-22(24)27/h2-3,7-14,19-20H,4-6,15H2,1H3,(H,29,32)(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233520
PNG
(US9351965, 127)
Show SMILES Cc1nc2ccc(cc2s1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2c(C)nc3ccccc23)C1
Show InChI InChI=1S/C31H30N6OS/c1-18-32-26-8-3-4-9-28(26)37(18)17-20-6-5-7-23(14-20)34-31(38)22-11-12-25-24(15-22)30(36-35-25)21-10-13-27-29(16-21)39-19(2)33-27/h3-4,8-13,15-16,20,23H,5-7,14,17H2,1-2H3,(H,34,38)(H,35,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233524
PNG
(US9351965, 131)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cc2ccccc2F)(C1)C(O)=O
Show InChI InChI=1S/C28H27FN4O3/c1-17-13-18(10-12-30-17)25-22-14-19(8-9-24(22)32-33-25)26(34)31-21-6-4-11-28(16-21,27(35)36)15-20-5-2-3-7-23(20)29/h2-3,5,7-10,12-14,21H,4,6,11,15-16H2,1H3,(H,31,34)(H,32,33)(H,35,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233398
PNG
(US9351965, 5 | US9351965, 6 | US9351965, 7 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2c(F)cccc2F)C1
Show InChI InChI=1S/C27H26F2N4O2/c1-16-12-17(9-11-30-16)25-20-13-18(7-8-24(20)32-33-25)26(34)31-19-4-3-10-27(35,14-19)15-21-22(28)5-2-6-23(21)29/h2,5-9,11-13,19,35H,3-4,10,14-15H2,1H3,(H,31,34)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233490
PNG
(US9351965, 97)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc3c(F)cccc3n2)C1
Show InChI InChI=1S/C28H27FN6O2/c1-17-12-18(9-11-30-17)26-21-13-19(7-8-24(21)32-33-26)27(36)31-20-4-3-10-28(37,14-20)16-35-15-22-23(29)5-2-6-25(22)34-35/h2,5-9,11-13,15,20,37H,3-4,10,14,16H2,1H3,(H,31,36)(H,32,33)/t20-,28-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233539
PNG
(US9351965, 146)
Show SMILES CC(C)Oc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC1CCc1ccccc1
Show InChI InChI=1S/C28H31N5O2/c1-19(2)35-26-18-21(14-15-29-26)27-24-17-22(11-13-25(24)30-31-27)28(34)32-33-16-6-9-23(33)12-10-20-7-4-3-5-8-20/h3-5,7-8,11,13-15,17-19,23H,6,9-10,12,16H2,1-2H3,(H,30,31)(H,32,34)
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US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233398
PNG
(US9351965, 5 | US9351965, 6 | US9351965, 7 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2c(F)cccc2F)C1
Show InChI InChI=1S/C27H26F2N4O2/c1-16-12-17(9-11-30-16)25-20-13-18(7-8-24(20)32-33-25)26(34)31-19-4-3-10-27(35,14-19)15-21-22(28)5-2-6-23(21)29/h2,5-9,11-13,19,35H,3-4,10,14-15H2,1H3,(H,31,34)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233476
PNG
(US9351965, 83)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2ncccc2=O)C1
Show InChI InChI=1S/C25H26N6O3/c1-16-12-17(8-11-26-16)23-20-13-18(6-7-21(20)29-30-23)24(33)28-19-4-2-9-25(34,14-19)15-31-22(32)5-3-10-27-31/h3,5-8,10-13,19,34H,2,4,9,14-15H2,1H3,(H,28,33)(H,29,30)/t19-,25-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233521
PNG
(US9351965, 128)
Show SMILES CCOC(=O)C1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1S/C30H31FN4O3/c1-3-38-29(37)30(17-22-7-4-5-9-25(22)31)13-6-8-23(18-30)33-28(36)21-10-11-26-24(16-21)27(35-34-26)20-12-14-32-19(2)15-20/h4-5,7,9-12,14-16,23H,3,6,8,13,17-18H2,1-2H3,(H,33,36)(H,34,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233491
PNG
(US9351965, 98)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2ncc3cc(F)ccc23)C1
Show InChI InChI=1S/C28H27FN6O2/c1-17-11-18(8-10-30-17)26-23-13-19(4-6-24(23)33-34-26)27(36)32-22-3-2-9-28(37,14-22)16-35-25-7-5-21(29)12-20(25)15-31-35/h4-8,10-13,15,22,37H,2-3,9,14,16H2,1H3,(H,32,36)(H,33,34)/t22-,28-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233448
PNG
(US9351965, 55)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCC(F)(Cc2ccccc2F)C1
Show InChI InChI=1S/C27H26F2N4O/c1-17-13-18(10-12-30-17)25-22-14-19(8-9-24(22)32-33-25)26(34)31-21-6-4-11-27(29,16-21)15-20-5-2-3-7-23(20)28/h2-3,5,7-10,12-14,21H,4,6,11,15-16H2,1H3,(H,31,34)(H,32,33)/t21-,27?/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233493
PNG
(US9351965, 100)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2ncc3ccc(F)cc23)C1
Show InChI InChI=1S/C28H27FN6O2/c1-17-11-18(8-10-30-17)26-23-12-19(5-7-24(23)33-34-26)27(36)32-22-3-2-9-28(37,14-22)16-35-25-13-21(29)6-4-20(25)15-31-35/h4-8,10-13,15,22,37H,2-3,9,14,16H2,1H3,(H,32,36)(H,33,34)/t22-,28-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233478
PNG
(US9351965, 85)
Show SMILES O[C@]1(Cn2ccccc2=O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1
Show InChI InChI=1S/C27H26N6O3/c34-24-5-1-2-12-33(24)17-27(36)10-3-4-20(15-27)29-26(35)18-6-8-22-21(14-18)25(31-30-22)19-7-9-23-28-11-13-32(23)16-19/h1-2,5-9,11-14,16,20,36H,3-4,10,15,17H2,(H,29,35)(H,30,31)/t20-,27-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233447
PNG
(US9351965, 54)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(F)(Cc2ccccc2F)C1
Show InChI InChI=1S/C27H26F2N4O/c1-17-13-18(10-12-30-17)25-22-14-19(8-9-24(22)32-33-25)26(34)31-21-6-4-11-27(29,16-21)15-20-5-2-3-7-23(20)28/h2-3,5,7-10,12-14,21H,4,6,11,15-16H2,1H3,(H,31,34)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233398
PNG
(US9351965, 5 | US9351965, 6 | US9351965, 7 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2c(F)cccc2F)C1
Show InChI InChI=1S/C27H26F2N4O2/c1-16-12-17(9-11-30-16)25-20-13-18(7-8-24(20)32-33-25)26(34)31-19-4-3-10-27(35,14-19)15-21-22(28)5-2-6-23(21)29/h2,5-9,11-13,19,35H,3-4,10,14-15H2,1H3,(H,31,34)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233498
PNG
(US9351965, 105)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc3ccc(cc3n2)C(F)(F)F)C1
Show InChI InChI=1S/C29H27F3N6O2/c1-17-11-18(8-10-33-17)26-23-12-19(5-7-24(23)35-36-26)27(39)34-22-3-2-9-28(40,14-22)16-38-15-20-4-6-21(29(30,31)32)13-25(20)37-38/h4-8,10-13,15,22,40H,2-3,9,14,16H2,1H3,(H,34,39)(H,35,36)/t22-,28-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233492
PNG
(US9351965, 101 | US9351965, 99)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc3cc(F)ccc3n2)C1
Show InChI InChI=1S/C28H27FN6O2/c1-17-11-18(8-10-30-17)26-23-13-19(4-6-25(23)32-33-26)27(36)31-22-3-2-9-28(37,14-22)16-35-15-20-12-21(29)5-7-24(20)34-35/h4-8,10-13,15,22,37H,2-3,9,14,16H2,1H3,(H,31,36)(H,32,33)/t22-,28-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233523
PNG
(US9351965, 130 | US9351965, 133)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2ccccc2F)C1
Show InChI InChI=1S/C28H29FN4O2/c1-18-13-19(10-12-30-18)26-23-14-20(8-9-25(23)32-33-26)27(35)31-22-6-4-11-28(16-22,17-34)15-21-5-2-3-7-24(21)29/h2-3,5,7-10,12-14,22,34H,4,6,11,15-17H2,1H3,(H,31,35)(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233518
PNG
(US9351965, 125)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3ccc(cc23)C(F)(F)F)C1
Show InChI InChI=1S/C29H27F3N6O/c1-17-11-19(9-10-33-17)27-24-13-20(6-8-25(24)36-37-27)28(39)35-23-4-2-3-18(12-23)16-38-26-14-22(29(30,31)32)7-5-21(26)15-34-38/h5-11,13-15,18,23H,2-4,12,16H2,1H3,(H,35,39)(H,36,37)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233477
PNG
(US9351965, 84)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ncccc2=O)C1
Show InChI InChI=1S/C25H26N6O3/c1-16-12-17(8-11-26-16)23-20-13-18(6-7-21(20)29-30-23)24(33)28-19-4-2-9-25(34,14-19)15-31-22(32)5-3-10-27-31/h3,5-8,10-13,19,34H,2,4,9,14-15H2,1H3,(H,28,33)(H,29,30)/t19-,25+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233505
PNG
(US9351965, 112)
Show SMILES Cc1nc2ccc(cc2s1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cc(C#N)c3ccccc23)C1
Show InChI InChI=1S/C32H28N6OS/c1-19-34-28-12-9-21(15-30(28)40-19)31-26-14-22(10-11-27(26)36-37-31)32(39)35-24-6-4-5-20(13-24)17-38-18-23(16-33)25-7-2-3-8-29(25)38/h2-3,7-12,14-15,18,20,24H,4-6,13,17H2,1H3,(H,35,39)(H,36,37)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233509
PNG
(US9351965, 116)
Show SMILES Cc1nc2cnccc2n1CC1CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1S/C28H29N7O/c1-17-12-20(8-11-30-17)27-23-14-21(6-7-24(23)33-34-27)28(36)32-22-5-3-4-19(13-22)16-35-18(2)31-25-15-29-10-9-26(25)35/h6-12,14-15,19,22H,3-5,13,16H2,1-2H3,(H,32,36)(H,33,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%