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Patent code US9353062

Compile Data Set for Download or QSAR
Found 2 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM230880
PNG
(US9353062, 1)
Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2cc1NC(=O)\C=C\CN(C)C
Show InChI InChI=1S/C30H29N5O3/c1-4-37-28-18-26-25(17-27(28)34-29(36)11-8-16-35(2)3)30(21(19-31)20-32-26)33-22-12-14-24(15-13-22)38-23-9-6-5-7-10-23/h5-15,17-18,20H,4,16H2,1-3H3,(H,32,33)(H,34,36)/b11-8+
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



HangzhouDeRenYuCheng Biotechnology Ltd

US Patent


Assay Description
Method B conducts the kinase assay with the following condition and procedure: The assay was performed using Kinase-Glo Plus luminescence kinase assa...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM230881
PNG
(US9353062, 2)
Show SMILES CN(C)C\C=C\C(=O)Nc1ccc2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1
Show InChI InChI=1S/C28H25N5O2/c1-33(2)16-6-9-27(34)31-22-12-15-26-25(17-22)28(20(18-29)19-30-26)32-21-10-13-24(14-11-21)35-23-7-4-3-5-8-23/h3-15,17,19H,16H2,1-2H3,(H,30,32)(H,31,34)/b9-6+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



HangzhouDeRenYuCheng Biotechnology Ltd

US Patent


Assay Description
Method B conducts the kinase assay with the following condition and procedure: The assay was performed using Kinase-Glo Plus luminescence kinase assa...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%