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Patent code US9353075

Compile Data Set for Download or QSAR
Found 66 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233790
PNG
(US9353075, 47)
Show SMILES CC[C@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C17H23NO4/c1-2-14-15(16(19)22-14)18-17(20)21-12-8-4-7-11-13-9-5-3-6-10-13/h3,5-6,9-10,14-15H,2,4,7-8,11-12H2,1H3,(H,18,20)/t14-,15-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM50439653
PNG
(CHEMBL2419830 | US9353075, 35)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCC1CCCCC1
Show InChI InChI=1S/C16H27NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h12-14H,2-11H2,1H3,(H,17,19)/t12-,14+/m0/s1
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n/an/a 5n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM50439649
PNG
(CHEMBL2419811 | US9353075, 7)
Show SMILES CCCCCCC[C@H](C)OC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C14H25NO4/c1-4-5-6-7-8-9-10(2)18-14(17)15-12-11(3)19-13(12)16/h10-12H,4-9H2,1-3H3,(H,15,17)/t10-,11-,12+/m0/s1
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n/an/a 5n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233791
PNG
(US9353075, 48)
Show SMILES CC[C@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H19NO4/c1-2-16-17(18(21)24-16)20-19(22)23-12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11,16-17H,2,12H2,1H3,(H,20,22)/t16-,17-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM50389023
PNG
(CHEMBL2064166 | US9353075, 6)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C16H21NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h2,4-5,8-9,12,14H,3,6-7,10-11H2,1H3,(H,17,19)/t12-,14+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032458
PNG
(CHEMBL3354144 | US9353075, 42)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)C1CCCCC1
Show InChI InChI=1S/C18H23NO4/c1-12-16(17(20)23-12)19-18(21)22-11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h7-10,12,14,16H,2-6,11H2,1H3,(H,19,21)/t12-,16+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM50439664
PNG
(CHEMBL2419814 | US9353075, 17)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H17NO4/c1-12-16(17(20)23-12)19-18(21)22-11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h2-10,12,16H,11H2,1H3,(H,19,21)/t12-,16+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439664
PNG
(CHEMBL2419814 | US9353075, 17)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H17NO4/c1-12-16(17(20)23-12)19-18(21)22-11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h2-10,12,16H,11H2,1H3,(H,19,21)/t12-,16+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM50032463
PNG
(CHEMBL3353547 | US9353075, 19)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCC1CCCCC1
Show InChI InChI=1S/C15H25NO4/c1-11-13(14(17)20-11)16-15(18)19-10-6-5-9-12-7-3-2-4-8-12/h11-13H,2-10H2,1H3,(H,16,18)/t11-,13+/m0/s1
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n/an/a 8n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM50032463
PNG
(CHEMBL3353547 | US9353075, 19)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCC1CCCCC1
Show InChI InChI=1S/C15H25NO4/c1-11-13(14(17)20-11)16-15(18)19-10-6-5-9-12-7-3-2-4-8-12/h11-13H,2-10H2,1H3,(H,16,18)/t11-,13+/m0/s1
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n/an/a 9n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233792
PNG
(US9353075, 49)
Show SMILES CC[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C17H23NO4/c1-2-14-15(16(19)22-14)18-17(20)21-12-8-4-7-11-13-9-5-3-6-10-13/h3,5-6,9-10,14-15H,2,4,7-8,11-12H2,1H3,(H,18,20)/t14-,15+/m0/s1
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n/an/a 9n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233776
PNG
(US9353075, 8)
Show SMILES CC(OC(=O)N[C@@H]1[C@H](C)OC1=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H19NO4/c1-12(24-19(22)20-17-13(2)23-18(17)21)14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-13,17H,1-2H3,(H,20,22)/t12?,13-,17+/m0/s1
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n/an/a 10n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233798
PNG
(US9353075, 55)
Show SMILES CC(C)[C@H]1OC(=O)[C@@H]1NC(=O)OC(C)(C)CCCCc1ccccc1
Show InChI InChI=1S/C20H29NO4/c1-14(2)17-16(18(22)24-17)21-19(23)25-20(3,4)13-9-8-12-15-10-6-5-7-11-15/h5-7,10-11,14,16-17H,8-9,12-13H2,1-4H3,(H,21,23)/t16-,17-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM50389023
PNG
(CHEMBL2064166 | US9353075, 6)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C16H21NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h2,4-5,8-9,12,14H,3,6-7,10-11H2,1H3,(H,17,19)/t12-,14+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233783
PNG
(US9353075, 22)
Show SMILES CC(CCCCc1ccccc1)OC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C17H23NO4/c1-12(8-6-7-11-14-9-4-3-5-10-14)21-17(20)18-15-13(2)22-16(15)19/h3-5,9-10,12-13,15H,6-8,11H2,1-2H3,(H,18,20)/t12?,13-,15+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233793
PNG
(US9353075, 50)
Show SMILES CC[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H19NO4/c1-2-16-17(18(21)24-16)20-19(22)23-12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11,16-17H,2,12H2,1H3,(H,20,22)/t16-,17+/m0/s1
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n/an/a 15n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439649
PNG
(CHEMBL2419811 | US9353075, 7)
Show SMILES CCCCCCC[C@H](C)OC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C14H25NO4/c1-4-5-6-7-8-9-10(2)18-14(17)15-12-11(3)19-13(12)16/h10-12H,4-9H2,1-3H3,(H,15,17)/t10-,11-,12+/m0/s1
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n/an/a 16n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439653
PNG
(CHEMBL2419830 | US9353075, 35)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCC1CCCCC1
Show InChI InChI=1S/C16H27NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h12-14H,2-11H2,1H3,(H,17,19)/t12-,14+/m0/s1
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n/an/a 16n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM50439655
PNG
(CHEMBL2419828 | US9353075, 18)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCOCc1ccccc1
Show InChI InChI=1S/C15H19NO5/c1-11-13(14(17)21-11)16-15(18)20-9-5-8-19-10-12-6-3-2-4-7-12/h2-4,6-7,11,13H,5,8-10H2,1H3,(H,16,18)/t11-,13+/m0/s1
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n/an/a 18n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439665
PNG
(CHEMBL2419819 | US9353075, 38)
Show SMILES C[C@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C16H21NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h2,4-5,8-9,12,14H,3,6-7,10-11H2,1H3,(H,17,19)/t12-,14-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233794
PNG
(US9353075, 51)
Show SMILES CC(C)[C@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C18H25NO4/c1-13(2)16-15(17(20)23-16)19-18(21)22-12-8-4-7-11-14-9-5-3-6-10-14/h3,5-6,9-10,13,15-16H,4,7-8,11-12H2,1-2H3,(H,19,21)/t15-,16-/m1/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032463
PNG
(CHEMBL3353547 | US9353075, 19)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCC1CCCCC1
Show InChI InChI=1S/C15H25NO4/c1-11-13(14(17)20-11)16-15(18)19-10-6-5-9-12-7-3-2-4-8-12/h11-13H,2-10H2,1H3,(H,16,18)/t11-,13+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032457
PNG
(CHEMBL3354143 | US9353075, 45)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccsc1
Show InChI InChI=1S/C16H15NO4S/c1-10-14(15(18)21-10)17-16(19)20-8-11-2-4-12(5-3-11)13-6-7-22-9-13/h2-7,9-10,14H,8H2,1H3,(H,17,19)/t10-,14+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233795
PNG
(US9353075, 52)
Show SMILES CC(C)[C@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H21NO4/c1-13(2)18-17(19(22)25-18)21-20(23)24-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,13,17-18H,12H2,1-2H3,(H,21,23)/t17-,18-/m1/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032453
PNG
(CHEMBL3354148 | US9353075, 46)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(OC2CCCCC2)cc1
Show InChI InChI=1S/C18H23NO5/c1-12-16(17(20)23-12)19-18(21)22-11-13-7-9-15(10-8-13)24-14-5-3-2-4-6-14/h7-10,12,14,16H,2-6,11H2,1H3,(H,19,21)/t12-,16+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032454
PNG
(CHEMBL3354147 | US9353075, 44)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H16F3NO4/c1-11-16(17(24)27-11)23-18(25)26-10-12-2-4-13(5-3-12)14-6-8-15(9-7-14)19(20,21)22/h2-9,11,16H,10H2,1H3,(H,23,25)/t11-,16+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM233783
PNG
(US9353075, 22)
Show SMILES CC(CCCCc1ccccc1)OC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C17H23NO4/c1-12(8-6-7-11-14-9-4-3-5-10-14)21-17(20)18-15-13(2)22-16(15)19/h3-5,9-10,12-13,15H,6-8,11H2,1-2H3,(H,18,20)/t12?,13-,15+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439656
PNG
(CHEMBL2419827 | US9353075, 2)
Show SMILES CCCCCCCCOC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C13H23NO4/c1-3-4-5-6-7-8-9-17-13(16)14-11-10(2)18-12(11)15/h10-11H,3-9H2,1-2H3,(H,14,16)/t10-,11+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233797
PNG
(US9353075, 54)
Show SMILES CC(C)[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H21NO4/c1-13(2)18-17(19(22)25-18)21-20(23)24-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,13,17-18H,12H2,1-2H3,(H,21,23)/t17-,18+/m1/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439657
PNG
(CHEMBL2419826 | US9353075, 40)
Show SMILES CCCCCCCOC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C12H21NO4/c1-3-4-5-6-7-8-16-12(15)13-10-9(2)17-11(10)14/h9-10H,3-8H2,1-2H3,(H,13,15)/t9-,10+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439655
PNG
(CHEMBL2419828 | US9353075, 18)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCOCc1ccccc1
Show InChI InChI=1S/C15H19NO5/c1-11-13(14(17)21-11)16-15(18)20-9-5-8-19-10-12-6-3-2-4-7-12/h2-4,6-7,11,13H,5,8-10H2,1H3,(H,16,18)/t11-,13+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM233776
PNG
(US9353075, 8)
Show SMILES CC(OC(=O)N[C@@H]1[C@H](C)OC1=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H19NO4/c1-12(24-19(22)20-17-13(2)23-18(17)21)14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-13,17H,1-2H3,(H,20,22)/t12?,13-,17+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50389023
PNG
(CHEMBL2064166 | US9353075, 6)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C16H21NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h2,4-5,8-9,12,14H,3,6-7,10-11H2,1H3,(H,17,19)/t12-,14+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233796
PNG
(US9353075, 53)
Show SMILES CC(C)[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C18H25NO4/c1-13(2)16-15(17(20)23-16)19-18(21)22-12-8-4-7-11-14-9-5-3-6-10-14/h3,5-6,9-10,13,15-16H,4,7-8,11-12H2,1-2H3,(H,19,21)/t15-,16+/m1/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439662
PNG
(CHEMBL2419821 | US9353075, 4)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCc1ccccc1
Show InChI InChI=1S/C14H17NO4/c1-10-12(13(16)19-10)15-14(17)18-9-5-8-11-6-3-2-4-7-11/h2-4,6-7,10,12H,5,8-9H2,1H3,(H,15,17)/t10-,12+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM233786
PNG
(US9353075, 28)
Show SMILES CC(C)C(CCCCc1ccccc1)OC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C19H27NO4/c1-13(2)16(12-8-7-11-15-9-5-4-6-10-15)24-19(22)20-17-14(3)23-18(17)21/h4-6,9-10,13-14,16-17H,7-8,11-12H2,1-3H3,(H,20,22)/t14-,16?,17+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032461
PNG
(CHEMBL3353549 | US9353075, 16)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCCCc1ccccc1
Show InChI InChI=1S/C18H25NO4/c1-14-16(17(20)23-14)19-18(21)22-13-9-4-2-3-6-10-15-11-7-5-8-12-15/h5,7-8,11-12,14,16H,2-4,6,9-10,13H2,1H3,(H,19,21)/t14-,16+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439654
PNG
(CHEMBL2419829 | US9353075, 36)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCOCCc1ccccc1
Show InChI InChI=1S/C15H19NO5/c1-11-13(14(17)21-11)16-15(18)20-10-9-19-8-7-12-5-3-2-4-6-12/h2-6,11,13H,7-10H2,1H3,(H,16,18)/t11-,13+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032452
PNG
(CHEMBL3354149 | US9353075, 43)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc2OCOc2c1
Show InChI InChI=1S/C13H13NO6/c1-7-11(12(15)20-7)14-13(16)17-5-8-2-3-9-10(4-8)19-6-18-9/h2-4,7,11H,5-6H2,1H3,(H,14,16)/t7-,11+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032446
PNG
(CHEMBL3353542 | US9353075, 15)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccc(F)cc1
Show InChI InChI=1S/C16H20FNO4/c1-11-14(15(19)22-11)18-16(20)21-10-4-2-3-5-12-6-8-13(17)9-7-12/h6-9,11,14H,2-5,10H2,1H3,(H,18,20)/t11-,14+/m0/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233799
PNG
(US9353075, 56)
Show SMILES CC(C)(C)[C@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C19H27NO4/c1-19(2,3)16-15(17(21)24-16)20-18(22)23-13-9-5-8-12-14-10-6-4-7-11-14/h4,6-7,10-11,15-16H,5,8-9,12-13H2,1-3H3,(H,20,22)/t15-,16+/m1/s1
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The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439658
PNG
(CHEMBL2419825 | US9353075, 39)
Show SMILES CCCCCCOC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C11H19NO4/c1-3-4-5-6-7-15-11(14)12-9-8(2)16-10(9)13/h8-9H,3-7H2,1-2H3,(H,12,14)/t8-,9+/m0/s1
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n/an/a 270n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233801
PNG
(US9353075, 58)
Show SMILES CC(C)(C)[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C19H27NO4/c1-19(2,3)16-15(17(21)24-16)20-18(22)23-13-9-5-8-12-14-10-6-4-7-11-14/h4,6-7,10-11,15-16H,5,8-9,12-13H2,1-3H3,(H,20,22)/t15-,16-/m1/s1
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n/an/a 278n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439668
PNG
(CHEMBL2417575 | US9353075, 26)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)Oc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C18H17NO5/c1-12-16(17(20)23-12)19-18(21)24-15-9-7-14(8-10-15)22-11-13-5-3-2-4-6-13/h2-10,12,16H,11H2,1H3,(H,19,21)/t12-,16+/m0/s1
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n/an/a 290n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM233787
PNG
(US9353075, 30)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OC1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C18H23NO4/c1-12-16(17(20)22-12)19-18(21)23-15-9-7-14(8-10-15)11-13-5-3-2-4-6-13/h2-6,12,14-16H,7-11H2,1H3,(H,19,21)/t12-,14?,15?,16+/m0/s1
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n/an/a 310n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439652
PNG
(CHEMBL2419809 | US9353075, 25)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OC(C)(C)CCCCc1ccccc1
Show InChI InChI=1S/C18H25NO4/c1-13-15(16(20)22-13)19-17(21)23-18(2,3)12-8-7-11-14-9-5-4-6-10-14/h4-6,9-10,13,15H,7-8,11-12H2,1-3H3,(H,19,21)/t13-,15+/m0/s1
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n/an/a 310n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439661
PNG
(CHEMBL2419822 | US9353075, 5)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCc1ccccc1
Show InChI InChI=1S/C15H19NO4/c1-11-13(14(17)20-11)16-15(18)19-10-6-5-9-12-7-3-2-4-8-12/h2-4,7-8,11,13H,5-6,9-10H2,1H3,(H,16,18)/t11-,13+/m0/s1
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n/an/a 390n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233800
PNG
(US9353075, 57)
Show SMILES CC(C)(C)[C@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H23NO4/c1-21(2,3)18-17(19(23)26-18)22-20(24)25-13-14-9-11-16(12-10-14)15-7-5-4-6-8-15/h4-12,17-18H,13H2,1-3H3,(H,22,24)/t17-,18+/m1/s1
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n/an/a 465n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439666
PNG
(CHEMBL2419818 | US9353075, 32)
Show SMILES C[C@@H]1OC(=O)[C@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C16H21NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h2,4-5,8-9,12,14H,3,6-7,10-11H2,1H3,(H,17,19)/t12-,14-/m0/s1
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n/an/a 480n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM233785
PNG
(US9353075, 27)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OC1(CCCc2ccccc2)COC1
Show InChI InChI=1S/C17H21NO5/c1-12-14(15(19)22-12)18-16(20)23-17(10-21-11-17)9-5-8-13-6-3-2-4-7-13/h2-4,6-7,12,14H,5,8-11H2,1H3,(H,18,20)/t12-,14+/m0/s1
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n/an/a 510n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233780
PNG
(US9353075, 12)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C15H21NO4/c1-8-12(13(17)19-8)16-14(18)20-15-5-9-2-10(6-15)4-11(3-9)7-15/h8-12H,2-7H2,1H3,(H,16,18)/t8-,9?,10?,11?,12+,15?/m0/s1
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n/an/a 540n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439659
PNG
(CHEMBL2419824 | US9353075, 1)
Show SMILES CCCCCOC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C10H17NO4/c1-3-4-5-6-14-10(13)11-8-7(2)15-9(8)12/h7-8H,3-6H2,1-2H3,(H,11,13)/t7-,8+/m0/s1
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n/an/a 670n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM233788
PNG
(US9353075, 31)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OC1CCC(CC1)=Cc1ccccc1
Show InChI InChI=1S/C18H21NO4/c1-12-16(17(20)22-12)19-18(21)23-15-9-7-14(8-10-15)11-13-5-3-2-4-6-13/h2-6,11-12,15-16H,7-10H2,1H3,(H,19,21)/b14-11-/t12-,15?,16+/m0/s1
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n/an/a 750n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM233778
PNG
(US9353075, 10)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OC1(C)CCCCC1
Show InChI InChI=1S/C12H19NO4/c1-8-9(10(14)16-8)13-11(15)17-12(2)6-4-3-5-7-12/h8-9H,3-7H2,1-2H3,(H,13,15)/t8-,9+/m0/s1
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n/an/a 840n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM233780
PNG
(US9353075, 12)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C15H21NO4/c1-8-12(13(17)19-8)16-14(18)20-15-5-9-2-10(6-15)4-11(3-9)7-15/h8-12H,2-7H2,1H3,(H,16,18)/t8-,9?,10?,11?,12+,15?/m0/s1
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n/an/a 870n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine acid amidase (NAAA)


(Homo sapiens (Human))
BDBM233802
PNG
(US9353075, 59)
Show SMILES CC(C)(C)[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H23NO4/c1-21(2,3)18-17(19(23)26-18)22-20(24)25-13-14-9-11-16(12-10-14)15-7-5-4-6-8-15/h4-12,17-18H,13H2,1-3H3,(H,22,24)/t17-,18-/m1/s1
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n/an/a 897n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439663
PNG
(CHEMBL2419823 | US9353075, 34)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCCc1ccccc1
Show InChI InChI=1S/C17H23NO4/c1-13-15(16(19)22-13)18-17(20)21-12-8-3-2-5-9-14-10-6-4-7-11-14/h4,6-7,10-11,13,15H,2-3,5,8-9,12H2,1H3,(H,18,20)/t13-,15+/m0/s1
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n/an/a 1.17E+3n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032460
PNG
(CHEMBL3353550 | US9353075, 3)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCc1ccc(C)cc1
Show InChI InChI=1S/C14H17NO4/c1-9-3-5-11(6-4-9)7-8-18-14(17)15-12-10(2)19-13(12)16/h3-6,10,12H,7-8H2,1-2H3,(H,15,17)/t10-,12+/m0/s1
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n/an/a 1.21E+3n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM233784
PNG
(US9353075, 23)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OC1(C)CCCC1
Show InChI InChI=1S/C11H17NO4/c1-7-8(9(13)15-7)12-10(14)16-11(2)5-3-4-6-11/h7-8H,3-6H2,1-2H3,(H,12,14)/t7-,8+/m0/s1
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n/an/a 1.23E+3n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM233777
PNG
(US9353075, 9)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OC1CCN(CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C17H20N2O5/c1-11-14(16(21)23-11)18-17(22)24-13-7-9-19(10-8-13)15(20)12-5-3-2-4-6-12/h2-6,11,13-14H,7-10H2,1H3,(H,18,22)/t11-,14+/m0/s1
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n/an/a 1.31E+3n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439660
PNG
(CHEMBL2419820 | US9353075, 33)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCc1ccccc1
Show InChI InChI=1S/C13H15NO4/c1-9-11(12(15)18-9)14-13(16)17-8-7-10-5-3-2-4-6-10/h2-6,9,11H,7-8H2,1H3,(H,14,16)/t9-,11+/m0/s1
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n/an/a 2.52E+3n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032464
PNG
(CHEMBL3353546 | US9353075, 20)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCC(C)(C)CCc1ccccc1
Show InChI InChI=1S/C17H23NO4/c1-12-14(15(19)22-12)18-16(20)21-11-17(2,3)10-9-13-7-5-4-6-8-13/h4-8,12,14H,9-11H2,1-3H3,(H,18,20)/t12-,14+/m0/s1
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n/an/a 3.43E+3n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439667
PNG
(CHEMBL2419817 | US9353075, 37)
Show SMILES C[C@H]1OC(=O)[C@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C16H21NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h2,4-5,8-9,12,14H,3,6-7,10-11H2,1H3,(H,17,19)/t12-,14+/m1/s1
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n/an/a 3.53E+3n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032466
PNG
(CHEMBL3353544 | US9353075, 24)
Show SMILES CCCCC1(COC1)OC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C12H19NO5/c1-3-4-5-12(6-16-7-12)18-11(15)13-9-8(2)17-10(9)14/h8-9H,3-7H2,1-2H3,(H,13,15)/t8-,9+/m0/s1
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n/an/a 3.76E+3n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032462
PNG
(CHEMBL3353548 | US9353075, 29)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OC1CCCCC1
Show InChI InChI=1S/C11H17NO4/c1-7-9(10(13)15-7)12-11(14)16-8-5-3-2-4-6-8/h7-9H,2-6H2,1H3,(H,12,14)/t7-,9+/m0/s1
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n/an/a 5.42E+3n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM233779
PNG
(US9353075, 11)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OC1(C)CCOCC1
Show InChI InChI=1S/C11H17NO5/c1-7-8(9(13)16-7)12-10(14)17-11(2)3-5-15-6-4-11/h7-8H,3-6H2,1-2H3,(H,12,14)/t7-,8+/m0/s1
PDB

UniProtKB/SwissProt

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n/an/a 4.00E+4n/an/an/an/an/an/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%