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Patent code US9353083

Compile Data Set for Download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM232950
PNG
(US9353083, 1)
Show SMILES COc1ccc(C[C@@H](NC(=O)CCc2c[nH]cn2)C(=O)N2CC(C2)(OCCCCO)c2ccccc2C)cc1
Show InChI InChI=1S/C30H38N4O5/c1-22-7-3-4-8-26(22)30(39-16-6-5-15-35)19-34(20-30)29(37)27(17-23-9-12-25(38-2)13-10-23)33-28(36)14-11-24-18-31-21-32-24/h3-4,7-10,12-13,18,21,27,35H,5-6,11,14-17,19-20H2,1-2H3,(H,31,32)(H,33,36)/t27-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.00E+3n/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The products are dissolved at 10 mM in DMSO. They are tested as a response dose at 0.1% of DMSO final. The range comprising 10 points and a zero star...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM232951
PNG
(US9353083, 6)
Show SMILES COc1ccc(C[C@@H](NC(=O)CCc2nc[nH]c2C)C(=O)N2CC(C2)(OCC2CC2)c2ccccc2C)cc1
Show InChI InChI=1S/C31H38N4O4/c1-21-6-4-5-7-26(21)31(39-17-24-8-9-24)18-35(19-31)30(37)28(16-23-10-12-25(38-3)13-11-23)34-29(36)15-14-27-22(2)32-20-33-27/h4-7,10-13,20,24,28H,8-9,14-19H2,1-3H3,(H,32,33)(H,34,36)/t28-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.50E+3n/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The products are dissolved at 10 mM in DMSO. They are tested as a response dose at 0.1% of DMSO final. The range comprising 10 points and a zero star...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM232950
PNG
(US9353083, 1)
Show SMILES COc1ccc(C[C@@H](NC(=O)CCc2c[nH]cn2)C(=O)N2CC(C2)(OCCCCO)c2ccccc2C)cc1
Show InChI InChI=1S/C30H38N4O5/c1-22-7-3-4-8-26(22)30(39-16-6-5-15-35)19-34(20-30)29(37)27(17-23-9-12-25(38-2)13-10-23)33-28(36)14-11-24-18-31-21-32-24/h3-4,7-10,12-13,18,21,27,35H,5-6,11,14-17,19-20H2,1-2H3,(H,31,32)(H,33,36)/t27-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 250n/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The products are dissolved at 10 mM in DMSO. They are tested as a response dose at 0.1% of DMSO final. The range comprising 10 points and a zero star...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM232951
PNG
(US9353083, 6)
Show SMILES COc1ccc(C[C@@H](NC(=O)CCc2nc[nH]c2C)C(=O)N2CC(C2)(OCC2CC2)c2ccccc2C)cc1
Show InChI InChI=1S/C31H38N4O4/c1-21-6-4-5-7-26(21)31(39-17-24-8-9-24)18-35(19-31)30(37)28(16-23-10-12-25(38-3)13-11-23)34-29(36)15-14-27-22(2)32-20-33-27/h4-7,10-13,20,24,28H,8-9,14-19H2,1-3H3,(H,32,33)(H,34,36)/t28-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 70n/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The products are dissolved at 10 mM in DMSO. They are tested as a response dose at 0.1% of DMSO final. The range comprising 10 points and a zero star...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%