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Patent code US9353090

Compile Data Set for Download or QSAR

Found 331 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234195
PNG
(US9353090, 328 | US9353090, 330)
Show SMILES CO[C@@H]1CN(CC[C@@H]1C(O)=O)c1nc(cs1)-c1cc(F)cc(C)c1OCc1ccc2CCN(C[C@H](C)c2c1)C1CCOCC1
Show InChI InChI=1S/C34H42FN3O5S/c1-21-14-25(35)16-29(30-20-44-34(36-30)38-11-7-27(33(39)40)31(18-38)41-3)32(21)43-19-23-4-5-24-6-10-37(17-22(2)28(24)15-23)26-8-12-42-13-9-26/h4-5,14-16,20,22,26-27,31H,6-13,17-19H2,1-3H3,(H,39,40)/t22-,27-,31+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233886
PNG
(US9353090, 14)
Show SMILES Cc1cccc(-c2cccc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1ccc2CN(CCc2c1C)C1CCOCC1
Show InChI InChI=1S/C35H41N3O4/c1-23-5-3-6-30(31-7-4-8-32(36-31)38-16-14-35(34(39)40)19-27(35)21-38)33(23)42-22-26-10-9-25-20-37(15-11-29(25)24(26)2)28-12-17-41-18-13-28/h3-10,27-28H,11-22H2,1-2H3,(H,39,40)/t27-,35+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233887
PNG
(US9353090, 15)
Show SMILES Cc1cccc(-c2cccc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1cc(C)c2CN(CCc2c1)C1CCOCC1
Show InChI InChI=1S/C35H41N3O4/c1-23-5-3-6-29(31-7-4-8-32(36-31)38-14-12-35(34(39)40)19-27(35)20-38)33(23)42-22-25-17-24(2)30-21-37(13-9-26(30)18-25)28-10-15-41-16-11-28/h3-8,17-18,27-28H,9-16,19-22H2,1-2H3,(H,39,40)/t27-,35+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233893
PNG
(US9353090, 21)
Show SMILES Cc1cccc(-c2cccc(n2)N2C[C@@H]3C[C@@]3(C2)C(O)=O)c1OCc1ccc2CN(CCc2c1C)C1CCOCC1
Show InChI InChI=1S/C34H39N3O4/c1-22-5-3-6-29(30-7-4-8-31(35-30)37-19-26-17-34(26,21-37)33(38)39)32(22)41-20-25-10-9-24-18-36(14-11-28(24)23(25)2)27-12-15-40-16-13-27/h3-10,26-27H,11-21H2,1-2H3,(H,38,39)/t26-,34-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233904
PNG
(US9353090, 32)
Show SMILES Cc1cccc(-c2cccc(n2)N2C[C@@H]3C[C@@]3(C2)C(O)=O)c1OCc1ccc2CCN(CCc2c1)C1COC1
Show InChI InChI=1S/C32H35N3O4/c1-21-4-2-5-27(28-6-3-7-29(33-28)35-16-25-15-32(25,20-35)31(36)37)30(21)39-17-22-8-9-23-10-12-34(26-18-38-19-26)13-11-24(23)14-22/h2-9,14,25-26H,10-13,15-20H2,1H3,(H,36,37)/t25-,32-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233917
PNG
(US9353090, 45)
Show SMILES COC[C@H]1N(C[C@@H]2C[C@]12C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1ccc2CN(CCc2c1)C1CCOC1
Show InChI InChI=1S/C34H39N3O5/c1-22-5-3-6-28(29-7-4-8-31(35-29)37-18-26-16-34(26,33(38)39)30(37)21-40-2)32(22)42-19-23-9-10-25-17-36(13-11-24(25)15-23)27-12-14-41-20-27/h3-10,15,26-27,30H,11-14,16-21H2,1-2H3,(H,38,39)/t26-,27?,30+,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233919
PNG
(US9353090, 47)
Show SMILES COC[C@H]1N(C[C@@H]2C[C@]12C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1ccc2CN(CCc2c1C)C1COC1
Show InChI InChI=1S/C34H39N3O5/c1-21-6-4-7-28(29-8-5-9-31(35-29)37-16-25-14-34(25,33(38)39)30(37)20-40-3)32(21)42-17-24-11-10-23-15-36(26-18-41-19-26)13-12-27(23)22(24)2/h4-11,25-26,30H,12-20H2,1-3H3,(H,38,39)/t25-,30+,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233929
PNG
(US9353090, 57)
Show SMILES COC[C@H]1N(C[C@@H]2C[C@]12C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1cc2CCN(Cc2c(OC)c1)C1CCOCC1
Show InChI InChI=1S/C36H43N3O6/c1-23-6-4-7-28(30-8-5-9-33(37-30)39-19-26-18-36(26,35(40)41)32(39)22-42-2)34(23)45-21-24-16-25-10-13-38(27-11-14-44-15-12-27)20-29(25)31(17-24)43-3/h4-9,16-17,26-27,32H,10-15,18-22H2,1-3H3,(H,40,41)/t26-,32+,36+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233943
PNG
(US9353090, 71)
Show SMILES CO[C@H]1CN(CC[C@H]1C(O)=O)c1cccc(n1)-c1cc(C)ccc1OCc1ccc2CN(CCc2c1C)C1CCOCC1
Show InChI InChI=1S/C35H43N3O5/c1-23-7-10-32(30(19-23)31-5-4-6-34(36-31)38-16-12-29(35(39)40)33(21-38)41-3)43-22-26-9-8-25-20-37(15-11-28(25)24(26)2)27-13-17-42-18-14-27/h4-10,19,27,29,33H,11-18,20-22H2,1-3H3,(H,39,40)/t29-,33+/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233953
PNG
(US9353090, 81)
Show SMILES CO[C@@H]1CN(CC[C@@H]1C(O)=O)c1cccc(n1)-c1cc(C)ccc1OCc1ccc2CCN(CCc2c1C)C1CCOCC1
Show InChI InChI=1S/C36H45N3O5/c1-24-7-10-33(31(21-24)32-5-4-6-35(37-32)39-18-13-30(36(40)41)34(22-39)42-3)44-23-27-9-8-26-11-16-38(17-12-29(26)25(27)2)28-14-19-43-20-15-28/h4-10,21,28,30,34H,11-20,22-23H2,1-3H3,(H,40,41)/t30-,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233956
PNG
(US9353090, 84)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1ccc2CN(CCc2c1)C1CCOCC1
Show InChI InChI=1S/C32H37N3O4S/c1-21-3-2-4-27(28-20-40-31(33-28)35-12-10-32(30(36)37)16-25(32)18-35)29(21)39-19-22-5-6-24-17-34(11-7-23(24)15-22)26-8-13-38-14-9-26/h2-6,15,20,25-26H,7-14,16-19H2,1H3,(H,36,37)/t25-,32+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233958
PNG
(US9353090, 86)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1ccc2CN(CC3COCCO3)CCc2c1C
Show InChI InChI=1S/C33H39N3O5S/c1-21-4-3-5-28(29-20-42-32(34-29)36-11-9-33(31(37)38)14-25(33)16-36)30(21)41-18-24-7-6-23-15-35(10-8-27(23)22(24)2)17-26-19-39-12-13-40-26/h3-7,20,25-26H,8-19H2,1-2H3,(H,37,38)/t25-,26?,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233983
PNG
(US9353090, 111)
Show SMILES Cc1ccc(OCc2ccc3CN(CCc3c2)C2COC2)c(c1)-c1csc(n1)N1CC[C@]2(C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C30H33N3O4S/c1-19-2-5-27(37-15-20-3-4-22-13-32(24-16-36-17-24)8-6-21(22)11-20)25(10-19)26-18-38-29(31-26)33-9-7-30(28(34)35)12-23(30)14-33/h2-5,10-11,18,23-24H,6-9,12-17H2,1H3,(H,34,35)/t23-,30+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233994
PNG
(US9353090, 122)
Show SMILES Cc1ccc(OCc2cc(C)c3CN(CCc3c2)C2CCOC2)c(c1)-c1csc(n1)N1CC[C@]2(C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C32H37N3O4S/c1-20-3-4-29(26(11-20)28-19-40-31(33-28)35-9-7-32(30(36)37)14-24(32)15-35)39-17-22-12-21(2)27-16-34(8-5-23(27)13-22)25-6-10-38-18-25/h3-4,11-13,19,24-25H,5-10,14-18H2,1-2H3,(H,36,37)/t24-,25?,32+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233995
PNG
(US9353090, 123)
Show SMILES Cc1ccc(OCc2cc(C)c3CN(CCc3c2)C2CCOCC2)c(c1)-c1csc(n1)N1CC[C@]2(C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C33H39N3O4S/c1-21-3-4-30(27(13-21)29-20-41-32(34-29)36-10-8-33(31(37)38)16-25(33)17-36)40-19-23-14-22(2)28-18-35(9-5-24(28)15-23)26-6-11-39-12-7-26/h3-4,13-15,20,25-26H,5-12,16-19H2,1-2H3,(H,37,38)/t25-,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233999
PNG
(US9353090, 127)
Show SMILES Cc1ccc(OCc2cc(C)c3CN(CC4COCCO4)CCc3c2C)c(c1)-c1csc(n1)N1CC[C@]2(C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C34H41N3O5S/c1-21-4-5-31(28(12-21)30-20-43-33(35-30)37-9-7-34(32(38)39)14-25(34)15-37)42-18-24-13-22(2)29-17-36(8-6-27(29)23(24)3)16-26-19-40-10-11-41-26/h4-5,12-13,20,25-26H,6-11,14-19H2,1-3H3,(H,38,39)/t25-,26?,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234001
PNG
(US9353090, 129)
Show SMILES Cc1ccc(OCc2cc(C)c3CN(CCc3c2C)C2CCOC2)c(c1)-c1csc(n1)N1CC[C@]2(C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C33H39N3O4S/c1-20-4-5-30(27(12-20)29-19-41-32(34-29)36-10-8-33(31(37)38)14-24(33)15-36)40-17-23-13-21(2)28-16-35(25-7-11-39-18-25)9-6-26(28)22(23)3/h4-5,12-13,19,24-25H,6-11,14-18H2,1-3H3,(H,37,38)/t24-,25?,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234012
PNG
(US9353090, 140)
Show SMILES Cc1cc(COc2c(C)cccc2-c2csc(n2)N2C[C@@H]3C[C@@]3(C2)C(O)=O)cc2CCN(Cc12)C1CCOCC1
Show InChI InChI=1S/C32H37N3O4S/c1-20-4-3-5-26(28-18-40-31(33-28)35-15-24-14-32(24,19-35)30(36)37)29(20)39-17-22-12-21(2)27-16-34(9-6-23(27)13-22)25-7-10-38-11-8-25/h3-5,12-13,18,24-25H,6-11,14-17,19H2,1-2H3,(H,36,37)/t24-,32-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234019
PNG
(US9353090, 147)
Show SMILES Cc1ccc(OCc2ccc3CCN(CCc3c2)C2CCOCC2)c(c1)-c1csc(n1)N1C[C@@H]2C[C@@]2(C1)C(O)=O
Show InChI InChI=1S/C32H37N3O4S/c1-21-2-5-29(27(14-21)28-19-40-31(33-28)35-17-25-16-32(25,20-35)30(36)37)39-18-22-3-4-23-6-10-34(11-7-24(23)15-22)26-8-12-38-13-9-26/h2-5,14-15,19,25-26H,6-13,16-18,20H2,1H3,(H,36,37)/t25-,32-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234035
PNG
(US9353090, 163)
Show SMILES COC[C@H]1N(C[C@@H]2C[C@]12C(O)=O)c1nc(cs1)-c1cc(C)ccc1OCc1ccc2CN(CCc2c1)C1CCOCC1
Show InChI InChI=1S/C33H39N3O5S/c1-21-3-6-29(41-18-22-4-5-24-16-35(10-7-23(24)14-22)26-8-11-40-12-9-26)27(13-21)28-20-42-32(34-28)36-17-25-15-33(25,31(37)38)30(36)19-39-2/h3-6,13-14,20,25-26,30H,7-12,15-19H2,1-2H3,(H,37,38)/t25-,30+,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234043
PNG
(US9353090, 171)
Show SMILES CO[C@H]1CN(CC[C@H]1C(O)=O)c1nc(cs1)-c1cccc(C)c1OCc1cc2CCN(Cc2c(OC)c1)C1CCOCC1
Show InChI InChI=1S/C33H41N3O6S/c1-21-5-4-6-25(28-20-43-33(34-28)36-12-8-26(32(37)38)30(18-36)40-3)31(21)42-19-22-15-23-7-11-35(24-9-13-41-14-10-24)17-27(23)29(16-22)39-2/h4-6,15-16,20,24,26,30H,7-14,17-19H2,1-3H3,(H,37,38)/t26-,30+/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234071
PNG
(US9353090, 199)
Show SMILES Cc1ccc(OCc2ccc3CN(CCCc3c2)C2CCOCC2)c(c1)-c1csc(n1)N1CC[C@]2(C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C33H39N3O4S/c1-22-4-7-30(28(15-22)29-21-41-32(34-29)36-12-10-33(31(37)38)17-26(33)19-36)40-20-23-5-6-25-18-35(11-2-3-24(25)16-23)27-8-13-39-14-9-27/h4-7,15-16,21,26-27H,2-3,8-14,17-20H2,1H3,(H,37,38)/t26-,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234074
PNG
(US9353090, 202)
Show SMILES Cc1ccc(OCc2ccc3C(=O)N(CCc3c2C)C2CCOCC2)c(c1)-c1cccc(n1)N1CC[C@]2(C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C35H39N3O5/c1-22-6-9-31(29(18-22)30-4-3-5-32(36-30)37-15-13-35(34(40)41)19-25(35)20-37)43-21-24-7-8-28-27(23(24)2)10-14-38(33(28)39)26-11-16-42-17-12-26/h3-9,18,25-26H,10-17,19-21H2,1-2H3,(H,40,41)/t25-,35+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234087
PNG
(US9353090, 217)
Show SMILES COC[C@H]1N(C[C@@H]2C[C@]12C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1cc2CCN(Cc2c(c1)C#N)C1CCOCC1
Show InChI InChI=1S/C36H40N4O5/c1-23-5-3-6-29(31-7-4-8-33(38-31)40-19-27-17-36(27,35(41)42)32(40)22-43-2)34(23)45-21-24-15-25-9-12-39(28-10-13-44-14-11-28)20-30(25)26(16-24)18-37/h3-8,15-16,27-28,32H,9-14,17,19-22H2,1-2H3,(H,41,42)/t27-,32+,36+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234117
PNG
(US9353090, 247)
Show SMILES CCO[C@@H]1CN(CC[C@@H]1C(O)=O)c1nccc(n1)-c1cccc(C)c1OCc1cc(C)c2CN(CCc2c1)C1CCOCC1
Show InChI InChI=1S/C35H44N4O5/c1-4-43-32-21-39(15-10-29(32)34(40)41)35-36-13-8-31(37-35)28-7-5-6-23(2)33(28)44-22-25-18-24(3)30-20-38(14-9-26(30)19-25)27-11-16-42-17-12-27/h5-8,13,18-19,27,29,32H,4,9-12,14-17,20-22H2,1-3H3,(H,40,41)/t29-,32+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234119
PNG
(US9353090, 249)
Show SMILES CO[C@@H]1CN(CC[C@@H]1C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1cc2CCN(Cc2c(OC)c1)C1CCOCC1
Show InChI InChI=1S/C35H43N3O6/c1-23-6-4-7-27(30-8-5-9-33(36-30)38-15-11-28(35(39)40)32(21-38)42-3)34(23)44-22-24-18-25-10-14-37(26-12-16-43-17-13-26)20-29(25)31(19-24)41-2/h4-9,18-19,26,28,32H,10-17,20-22H2,1-3H3,(H,39,40)/t28-,32+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234129
PNG
(US9353090, 260)
Show SMILES CCO[C@@H]1CN(CC[C@@H]1C(O)=O)c1cccc(n1)-c1cccc(Cl)c1OCc1cc2CCN(Cc2c(OC)c1)C1CCOCC1
Show InChI InChI=1S/C35H42ClN3O6/c1-3-44-32-21-39(15-11-27(32)35(40)41)33-9-5-8-30(37-33)26-6-4-7-29(36)34(26)45-22-23-18-24-10-14-38(25-12-16-43-17-13-25)20-28(24)31(19-23)42-2/h4-9,18-19,25,27,32H,3,10-17,20-22H2,1-2H3,(H,40,41)/t27-,32+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234130
PNG
(US9353090, 261)
Show SMILES CCO[C@H]1CN(CC[C@H]1C(O)=O)c1nc(cs1)-c1cccc(Cl)c1OCc1cc2CCN(Cc2c(OC)c1)C1CCOCC1
Show InChI InChI=1S/C33H40ClN3O6S/c1-3-42-30-18-37(12-8-25(30)32(38)39)33-35-28(20-44-33)24-5-4-6-27(34)31(24)43-19-21-15-22-7-11-36(23-9-13-41-14-10-23)17-26(22)29(16-21)40-2/h4-6,15-16,20,23,25,30H,3,7-14,17-19H2,1-2H3,(H,38,39)/t25-,30+/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234155
PNG
(US9353090, 286)
Show SMILES COCc1cc(COc2c(C)cccc2-c2cccc(n2)N2CC[C@@H]([C@@H](C2)OC)C(O)=O)cc2CCN(Cc12)C1CCOCC1
Show InChI InChI=1S/C36H45N3O6/c1-24-6-4-7-29(32-8-5-9-34(37-32)39-15-11-30(36(40)41)33(21-39)43-3)35(24)45-22-25-18-26-10-14-38(28-12-16-44-17-13-28)20-31(26)27(19-25)23-42-2/h4-9,18-19,28,30,33H,10-17,20-23H2,1-3H3,(H,40,41)/t30-,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234173
PNG
(US9353090, 306)
Show SMILES CC(N1CCc2c(C)c(COc3ccccc3-c3cccc(n3)N3CC[C@]4(C[C@H]4C3)C(O)=O)ccc2C1)c1ccccn1
Show InChI InChI=1S/C36H38N4O3/c1-24-27(14-13-26-21-39(18-15-29(24)26)25(2)31-9-5-6-17-37-31)23-43-33-11-4-3-8-30(33)32-10-7-12-34(38-32)40-19-16-36(35(41)42)20-28(36)22-40/h3-14,17,25,28H,15-16,18-23H2,1-2H3,(H,41,42)/t25?,28-,36+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234175
PNG
(US9353090, 308)
Show SMILES Cc1c(COc2ccccc2-c2cccc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)ccc2CN(Cc3cncn3C)CCc12
Show InChI InChI=1S/C34H37N5O3/c1-23-25(11-10-24-18-38(14-12-28(23)24)20-27-17-35-22-37(27)2)21-42-31-8-4-3-6-29(31)30-7-5-9-32(36-30)39-15-13-34(33(40)41)16-26(34)19-39/h3-11,17,22,26H,12-16,18-21H2,1-2H3,(H,40,41)/t26-,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234192
PNG
(US9353090, 325)
Show SMILES CO[C@H]1CN(CC[C@H]1C(O)=O)c1nc(cs1)-c1cccc(C)c1OCc1ccc2CCN(C[C@H](C)c2c1)C1COC1
Show InChI InChI=1S/C32H39N3O5S/c1-20-5-4-6-25(28-19-41-32(33-28)35-12-10-26(31(36)37)29(15-35)38-3)30(20)40-16-22-7-8-23-9-11-34(24-17-39-18-24)14-21(2)27(23)13-22/h4-8,13,19,21,24,26,29H,9-12,14-18H2,1-3H3,(H,36,37)/t21-,26+,29-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233874
PNG
(US9353090, 2)
Show SMILES OC(=O)[C@]12C[C@H]1CN(CC2)c1cccc(n1)-c1ccccc1OCc1ccc2CN(CCc2c1)C1COC1
Show InChI InChI=1S/C31H33N3O4/c35-30(36)31-11-13-34(17-24(31)15-31)29-7-3-5-27(32-29)26-4-1-2-6-28(26)38-18-21-8-9-23-16-33(25-19-37-20-25)12-10-22(23)14-21/h1-9,14,24-25H,10-13,15-20H2,(H,35,36)/t24-,31+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233875
PNG
(US9353090, 3)
Show SMILES Cc1c(COc2ccccc2-c2cccc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)ccc2CN(CCc12)C1CCOCC1
Show InChI InChI=1S/C34H39N3O4/c1-23-25(10-9-24-20-36(15-11-28(23)24)27-12-17-40-18-13-27)22-41-31-7-3-2-5-29(31)30-6-4-8-32(35-30)37-16-14-34(33(38)39)19-26(34)21-37/h2-10,26-27H,11-22H2,1H3,(H,38,39)/t26-,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233878
PNG
(US9353090, 6)
Show SMILES Cc1c(COc2ccccc2-c2cccc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)ccc2CN(CCc12)C1CCOCC1
Show InChI InChI=1S/C34H39N3O4/c1-23-25(10-9-24-20-36(15-11-28(23)24)27-12-17-40-18-13-27)22-41-31-7-3-2-5-29(31)30-6-4-8-32(35-30)37-16-14-34(33(38)39)19-26(34)21-37/h2-10,26-27H,11-22H2,1H3,(H,38,39)/t26-,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233891
PNG
(US9353090, 19)
Show SMILES Cc1ccc(OCc2ccc3CN(CCc3c2C)C2COC2)c(c1)-c1cccc(n1)N1CC[C@]2(C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C33H37N3O4/c1-21-6-9-30(40-18-24-8-7-23-16-35(26-19-39-20-26)12-10-27(23)22(24)2)28(14-21)29-4-3-5-31(34-29)36-13-11-33(32(37)38)15-25(33)17-36/h3-9,14,25-26H,10-13,15-20H2,1-2H3,(H,37,38)/t25-,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233926
PNG
(US9353090, 54)
Show SMILES CCc1cc(COc2c(C)cccc2-c2cccc(n2)N2C[C@@H]3C[C@@]3([C@H]2COC)C(O)=O)cc2CCN(Cc12)C1COC1
Show InChI InChI=1S/C35H41N3O5/c1-4-24-13-23(14-25-11-12-37(17-29(24)25)27-19-42-20-27)18-43-33-22(2)7-5-8-28(33)30-9-6-10-32(36-30)38-16-26-15-35(26,34(39)40)31(38)21-41-3/h5-10,13-14,26-27,31H,4,11-12,15-21H2,1-3H3,(H,39,40)/t26-,31+,35+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233935
PNG
(US9353090, 63)
Show SMILES COC[C@@H]1N(C[C@H]2C[C@@]12C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1cc(C)c2CN(CCc2c1)C1CCOCC1
Show InChI InChI=1S/C36H43N3O5/c1-23-6-4-7-29(31-8-5-9-33(37-31)39-19-27-18-36(27,35(40)41)32(39)22-42-3)34(23)44-21-25-16-24(2)30-20-38(13-10-26(30)17-25)28-11-14-43-15-12-28/h4-9,16-17,27-28,32H,10-15,18-22H2,1-3H3,(H,40,41)/t27-,32+,36+/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233939
PNG
(US9353090, 67)
Show SMILES CO[C@@H]1CN(CC[C@@H]1C(O)=O)c1cccc(n1)-c1cccc(C)c1OCc1ccc2CN(CCc2c1)C1CCOCC1
Show InChI InChI=1S/C34H41N3O5/c1-23-5-3-6-28(30-7-4-8-32(35-30)37-16-12-29(34(38)39)31(21-37)40-2)33(23)42-22-24-9-10-26-20-36(15-11-25(26)19-24)27-13-17-41-18-14-27/h3-10,19,27,29,31H,11-18,20-22H2,1-2H3,(H,38,39)/t29-,31+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


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More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233949
PNG
(US9353090, 77 | US9353090, 78)
Show SMILES CO[C@@H]1CN(CC[C@@H]1C(O)=O)c1cccc(n1)-c1cc(C)ccc1OCc1cc(C)c2CN(CCc2c1)C1CCOC1
Show InChI InChI=1S/C34H41N3O5/c1-22-7-8-31(42-20-24-16-23(2)29-18-36(12-9-25(29)17-24)26-11-14-41-21-26)28(15-22)30-5-4-6-33(35-30)37-13-10-27(34(38)39)32(19-37)40-3/h4-8,15-17,26-27,32H,9-14,18-21H2,1-3H3,(H,38,39)/t26?,27-,32+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233961
PNG
(US9353090, 89)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1ccc2CN(CCc2c1C)C1CCOCC1
Show InChI InChI=1S/C33H39N3O4S/c1-21-4-3-5-28(29-20-41-32(34-29)36-13-11-33(31(37)38)16-25(33)18-36)30(21)40-19-24-7-6-23-17-35(12-8-27(23)22(24)2)26-9-14-39-15-10-26/h3-7,20,25-26H,8-19H2,1-2H3,(H,37,38)/t25-,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233974
PNG
(US9353090, 102)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1cc(C)c2CN(CCc2c1C)C1COC1
Show InChI InChI=1S/C32H37N3O4S/c1-19-5-4-6-26(28-18-40-31(33-28)35-10-8-32(30(36)37)12-23(32)13-35)29(19)39-15-22-11-20(2)27-14-34(24-16-38-17-24)9-7-25(27)21(22)3/h4-6,11,18,23-24H,7-10,12-17H2,1-3H3,(H,36,37)/t23-,32+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233977
PNG
(US9353090, 105)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1ccc2CCN(CCc2c1C)C1CCOCC1
Show InChI InChI=1S/C34H41N3O4S/c1-22-4-3-5-29(30-21-42-33(35-30)37-15-12-34(32(38)39)18-26(34)19-37)31(22)41-20-25-7-6-24-8-13-36(14-9-28(24)23(25)2)27-10-16-40-17-11-27/h3-7,21,26-27H,8-20H2,1-2H3,(H,38,39)/t26-,34+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233978
PNG
(US9353090, 106)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1ccc2CCN(CCc2c1C)C1CCOC1
Show InChI InChI=1S/C33H39N3O4S/c1-21-4-3-5-28(29-20-41-32(34-29)36-14-11-33(31(37)38)16-25(33)17-36)30(21)40-18-24-7-6-23-8-12-35(26-10-15-39-19-26)13-9-27(23)22(24)2/h3-7,20,25-26H,8-19H2,1-2H3,(H,37,38)/t25-,26?,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233981
PNG
(US9353090, 109)
Show SMILES Cc1cccc(-c2csc(n2)N2CC[C@]3(C[C@H]3C2)C(O)=O)c1OCc1cnc2CN(CCc2c1)C1CCOC1
Show InChI InChI=1S/C30H34N4O4S/c1-19-3-2-4-24(26-18-39-29(32-26)34-9-7-30(28(35)36)12-22(30)14-34)27(19)38-16-20-11-21-5-8-33(15-25(21)31-13-20)23-6-10-37-17-23/h2-4,11,13,18,22-23H,5-10,12,14-17H2,1H3,(H,35,36)/t22-,23?,30+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233985
PNG
(US9353090, 113)
Show SMILES Cc1ccc(OCc2ccc3CN(CCc3c2)C2CCCOC2)c(c1)-c1csc(n1)N1CC[C@]2(C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C32H37N3O4S/c1-21-4-7-29(27(13-21)28-20-40-31(33-28)35-11-9-32(30(36)37)15-25(32)17-35)39-18-22-5-6-24-16-34(10-8-23(24)14-22)26-3-2-12-38-19-26/h4-7,13-14,20,25-26H,2-3,8-12,15-19H2,1H3,(H,36,37)/t25-,26?,32+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM233993
PNG
(US9353090, 121)
Show SMILES Cc1ccc(OCc2cc(C)c3CN(CCc3c2)C2CCCOC2)c(c1)-c1csc(n1)N1CC[C@]2(C[C@H]2C1)C(O)=O
Show InChI InChI=1S/C33H39N3O4S/c1-21-5-6-30(27(12-21)29-20-41-32(34-29)36-10-8-33(31(37)38)15-25(33)16-36)40-18-23-13-22(2)28-17-35(9-7-24(28)14-23)26-4-3-11-39-19-26/h5-6,12-14,20,25-26H,3-4,7-11,15-19H2,1-2H3,(H,37,38)/t25-,26?,33+/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234016
PNG
(US9353090, 144)
Show SMILES Cc1cccc(-c2csc(n2)N2C[C@@H]3C[C@@]3(C2)C(O)=O)c1OCc1ccc2CCN(CCc2c1C)C1CCOCC1
Show InChI InChI=1S/C33H39N3O4S/c1-21-4-3-5-28(29-19-41-32(34-29)36-17-25-16-33(25,20-36)31(37)38)30(21)40-18-24-7-6-23-8-12-35(13-9-27(23)22(24)2)26-10-14-39-15-11-26/h3-7,19,25-26H,8-18,20H2,1-2H3,(H,37,38)/t25-,33-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234021
PNG
(US9353090, 149)
Show SMILES Cc1ccc(OCc2ccc3CCN(CCc3c2C)C2COC2)c(c1)-c1csc(n1)N1C[C@@H]2C[C@@]2(C1)C(O)=O
Show InChI InChI=1S/C31H35N3O4S/c1-19-3-6-28(26(11-19)27-17-39-30(32-27)34-13-23-12-31(23,18-34)29(35)36)38-14-22-5-4-21-7-9-33(24-15-37-16-24)10-8-25(21)20(22)2/h3-6,11,17,23-24H,7-10,12-16,18H2,1-2H3,(H,35,36)/t23-,31-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM234038
PNG
(US9353090, 166)
Show SMILES CO[C@H]1CN(CC[C@H]1C(O)=O)c1nc(cs1)-c1cccc(C)c1OCc1ccc2CN(CCc2c1C)C1COC1
Show InChI InChI=1S/C31H37N3O5S/c1-19-5-4-6-25(27-18-40-31(32-27)34-12-10-26(30(35)36)28(14-34)37-3)29(19)39-15-22-8-7-21-13-33(23-16-38-17-23)11-9-24(21)20(22)2/h4-8,18,23,26,28H,9-17H2,1-3H3,(H,35,36)/t26-,28+/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The sGC cellular activator assay is performed in the presence and absence of 50% human serum (HS) using Chinese hamster ovary cells that have been st...


Citation and Details
More data for this
Ligand-Target Pair
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