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Patent code US9353104

Compile Data Set for Download or QSAR
Found 130 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234817
PNG
(US9353104, 121)
Show SMILES Cc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc4CCCc4n3)nn(C)c2=O)n(C)n1
Show InChI InChI=1S/C23H28N6O2/c1-14-9-17(28(2)26-14)12-24-21-11-22(27-29(3)23(21)30)31-13-16-10-18(16)20-8-7-15-5-4-6-19(15)25-20/h7-9,11,16,18,24H,4-6,10,12-13H2,1-3H3/t16-,18+/m1/s1
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US Patent
0.00100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234715
PNG
(US9353104, 3)
Show SMILES Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc4ccccc4n3)nn(C)c2=O)s1
Show InChI InChI=1S/C22H22N6O2S/c1-13-25-26-21(31-13)11-23-19-10-20(27-28(2)22(19)29)30-12-15-9-16(15)18-8-7-14-5-3-4-6-17(14)24-18/h3-8,10,15-16,23H,9,11-12H2,1-2H3/t15-,16+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234827
PNG
(US9353104, 132)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cc(C)nn2C)c(=O)n(C)n1
Show InChI InChI=1S/C21H26N6O3/c1-13-7-15(26(2)24-13)10-22-19-9-20(25-27(3)21(19)28)30-12-14-8-17(14)18-6-5-16(29-4)11-23-18/h5-7,9,11,14,17,22H,8,10,12H2,1-4H3/t14-,17+/m1/s1
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US Patent
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234819
PNG
(US9353104, 124)
Show SMILES Cc1cnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc4CCCc4n3)nn(C)c2=O)s1
Show InChI InChI=1S/C22H25N5O2S/c1-13-10-24-21(30-13)11-23-19-9-20(26-27(2)22(19)28)29-12-15-8-16(15)18-7-6-14-4-3-5-17(14)25-18/h6-7,9-10,15-16,23H,3-5,8,11-12H2,1-2H3/t15-,16+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234818
PNG
(US9353104, 123)
Show SMILES Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc4CCCc4n3)nn(C)c2=O)s1
Show InChI InChI=1S/C21H24N6O2S/c1-12-24-25-20(30-12)10-22-18-9-19(26-27(2)21(18)28)29-11-14-8-15(14)17-7-6-13-4-3-5-16(13)23-17/h6-7,9,14-15,22H,3-5,8,10-11H2,1-2H3/t14-,15+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234762
PNG
(US9353104, 56)
Show SMILES Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc4CCCc4n3)nn(C)c2=O)c(C)n1
Show InChI InChI=1S/C25H29N5O2/c1-15-7-8-18(16(2)27-15)13-26-23-12-24(29-30(3)25(23)31)32-14-19-11-20(19)22-10-9-17-5-4-6-21(17)28-22/h7-10,12,19-20,26H,4-6,11,13-14H2,1-3H3/t19-,20+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234726
PNG
(US9353104, 14)
Show SMILES Cc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(C)cn3)nn(C)c2=O)n(C)n1
Show InChI InChI=1S/C21H26N6O2/c1-13-5-6-18(22-10-13)17-8-15(17)12-29-20-9-19(21(28)27(4)25-20)23-11-16-7-14(2)24-26(16)3/h5-7,9-10,15,17,23H,8,11-12H2,1-4H3/t15-,17+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234756
PNG
(US9353104, 50)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ccc(C)nc2C)c(=O)n(C)n1
Show InChI InChI=1S/C23H27N5O3/c1-14-5-6-16(15(2)26-14)11-24-21-10-22(27-28(3)23(21)29)31-13-17-9-19(17)20-8-7-18(30-4)12-25-20/h5-8,10,12,17,19,24H,9,11,13H2,1-4H3/t17-,19+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234825
PNG
(US9353104, 130)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ncc(C)s2)c(=O)n(C)n1
Show InChI InChI=1S/C20H23N5O3S/c1-12-8-23-19(29-12)10-22-17-7-18(24-25(2)20(17)26)28-11-13-6-15(13)16-5-4-14(27-3)9-21-16/h4-5,7-9,13,15,22H,6,10-11H2,1-3H3/t13-,15+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234835
PNG
(US9353104, 140)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nn(C)c(=O)c(NCc2nnc(C)s2)c1Br
Show InChI InChI=1S/C19H21BrN6O3S/c1-10-23-24-15(30-10)8-22-17-16(20)18(25-26(2)19(17)27)29-9-11-6-13(11)14-5-4-12(28-3)7-21-14/h4-5,7,11,13,22H,6,8-9H2,1-3H3/t11-,13+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234763
PNG
(US9353104, 57)
Show SMILES Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc4ccccc4n3)nn(C)c2=O)c(C)n1
Show InChI InChI=1S/C26H27N5O2/c1-16-8-9-19(17(2)28-16)14-27-24-13-25(30-31(3)26(24)32)33-15-20-12-21(20)23-11-10-18-6-4-5-7-22(18)29-23/h4-11,13,20-21,27H,12,14-15H2,1-3H3/t20-,21+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234836
PNG
(US9353104, 141)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nn(C)c(=O)c(NCc2nnc(C)s2)c1Cl
Show InChI InChI=1S/C19H21ClN6O3S/c1-10-23-24-15(30-10)8-22-17-16(20)18(25-26(2)19(17)27)29-9-11-6-13(11)14-5-4-12(28-3)7-21-14/h4-5,7,11,13,22H,6,8-9H2,1-3H3/t11-,13+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234812
PNG
(US9353104, 116)
Show SMILES Cc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3cccc(C)n3)nn(C)c2=O)n(C)n1
Show InChI InChI=1S/C21H26N6O2/c1-13-6-5-7-18(23-13)17-9-15(17)12-29-20-10-19(21(28)27(4)25-20)22-11-16-8-14(2)24-26(16)3/h5-8,10,15,17,22H,9,11-12H2,1-4H3/t15-,17+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234820
PNG
(US9353104, 125)
Show SMILES Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc4CCCc4n3)nn(C)c2=O)cn1
Show InChI InChI=1S/C22H26N6O2/c1-27-12-14(11-24-27)10-23-20-9-21(26-28(2)22(20)29)30-13-16-8-17(16)19-7-6-15-4-3-5-18(15)25-19/h6-7,9,11-12,16-17,23H,3-5,8,10,13H2,1-2H3/t16-,17+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234743
PNG
(US9353104, 31)
Show SMILES Cc1cnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(C)cn3)nn(C)c2=O)s1
Show InChI InChI=1S/C20H23N5O2S/c1-12-4-5-16(21-8-12)15-6-14(15)11-27-18-7-17(20(26)25(3)24-18)22-10-19-23-9-13(2)28-19/h4-5,7-9,14-15,22H,6,10-11H2,1-3H3/t14-,15+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234758
PNG
(US9353104, 52)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ccc(C)nc2C)c(=O)n(C)n1
Show InChI InChI=1S/C23H27N5O2/c1-14-5-8-20(24-11-14)19-9-18(19)13-30-22-10-21(23(29)28(4)27-22)25-12-17-7-6-15(2)26-16(17)3/h5-8,10-11,18-19,25H,9,12-13H2,1-4H3/t18-,19+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234789
PNG
(US9353104, 89)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cc(C)no2)c(=O)n(C)n1
Show InChI InChI=1S/C20H23N5O4/c1-12-6-15(29-24-12)10-22-18-8-19(23-25(2)20(18)26)28-11-13-7-16(13)17-5-4-14(27-3)9-21-17/h4-6,8-9,13,16,22H,7,10-11H2,1-3H3/t13-,16+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234749
PNG
(US9353104, 37)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cn(C)nc2C)c(=O)n(C)n1
Show InChI InChI=1S/C21H26N6O3/c1-13-15(11-26(2)24-13)9-22-19-8-20(25-27(3)21(19)28)30-12-14-7-17(14)18-6-5-16(29-4)10-23-18/h5-6,8,10-11,14,17,22H,7,9,12H2,1-4H3/t14-,17+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234787
PNG
(US9353104, 87)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cc(C)on2)c(=O)n(C)n1
Show InChI InChI=1S/C20H23N5O4/c1-12-6-14(24-29-12)9-21-18-8-19(23-25(2)20(18)26)28-11-13-7-16(13)17-5-4-15(27-3)10-22-17/h4-6,8,10,13,16,21H,7,9,11H2,1-3H3/t13-,16+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234725
PNG
(US9353104, 13)
Show SMILES Cc1ncc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(C)cn3)nn(C)c2=O)s1
Show InChI InChI=1S/C20H23N5O2S/c1-12-4-5-17(22-8-12)16-6-14(16)11-27-19-7-18(20(26)25(3)24-19)23-10-15-9-21-13(2)28-15/h4-5,7-9,14,16,23H,6,10-11H2,1-3H3/t14-,16+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234713
PNG
(US9353104, 1)
Show SMILES Cn1ccc(n1)[C@H]1C[C@@H]1COc1cc(Br)c(=O)n(C)n1
Show InChI InChI=1S/C13H15BrN4O2/c1-17-4-3-11(15-17)9-5-8(9)7-20-12-6-10(14)13(19)18(2)16-12/h3-4,6,8-9H,5,7H2,1-2H3/t8-,9+/m1/s1
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0.0130n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234826
PNG
(US9353104, 131)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cnn(C)c2)c(=O)n(C)n1
Show InChI InChI=1S/C20H24N6O3/c1-25-11-13(9-23-25)8-21-18-7-19(24-26(2)20(18)27)29-12-14-6-16(14)17-5-4-15(28-3)10-22-17/h4-5,7,9-11,14,16,21H,6,8,12H2,1-3H3/t14-,16+/m1/s1
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0.0140n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234716
PNG
(US9353104, 4)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2nnc(C)s2)c(=O)n(C)n1
Show InChI InChI=1S/C19H22N6O3S/c1-11-22-23-18(29-11)9-21-16-7-17(24-25(2)19(16)26)28-10-12-6-14(12)15-5-4-13(27-3)8-20-15/h4-5,7-8,12,14,21H,6,9-10H2,1-3H3/t12-,14+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234777
PNG
(US9353104, 72)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ccc(C)cn2)c(=O)n(C)n1
Show InChI InChI=1S/C22H25N5O3/c1-14-4-5-16(23-10-14)11-24-20-9-21(26-27(2)22(20)28)30-13-15-8-18(15)19-7-6-17(29-3)12-25-19/h4-7,9-10,12,15,18,24H,8,11,13H2,1-3H3/t15-,18+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234760
PNG
(US9353104, 54)
Show SMILES Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(Cl)cn3)nn(C)c2=O)c(C)n1
Show InChI InChI=1S/C22H24ClN5O2/c1-13-4-5-15(14(2)26-13)10-24-20-9-21(27-28(3)22(20)29)30-12-16-8-18(16)19-7-6-17(23)11-25-19/h4-7,9,11,16,18,24H,8,10,12H2,1-3H3/t16-,18+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234745
PNG
(US9353104, 33)
Show SMILES Cc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(Cl)cn3)nn(C)c2=O)n(C)n1
Show InChI InChI=1S/C20H23ClN6O2/c1-12-6-15(26(2)24-12)10-23-18-8-19(25-27(3)20(18)28)29-11-13-7-16(13)17-5-4-14(21)9-22-17/h4-6,8-9,13,16,23H,7,10-11H2,1-3H3/t13-,16+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234828
PNG
(US9353104, 133)
Show SMILES COc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC)cn3)nn(C)c2=O)cc1
Show InChI InChI=1S/C23H26N4O4/c1-27-23(28)21(24-12-15-4-6-17(29-2)7-5-15)11-22(26-27)31-14-16-10-19(16)20-9-8-18(30-3)13-25-20/h4-9,11,13,16,19,24H,10,12,14H2,1-3H3/t16-,19+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234761
PNG
(US9353104, 55)
Show SMILES Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccccn3)nn(C)c2=O)c(C)n1
Show InChI InChI=1S/C22H25N5O2/c1-14-7-8-16(15(2)25-14)12-24-20-11-21(26-27(3)22(20)28)29-13-17-10-18(17)19-6-4-5-9-23-19/h4-9,11,17-18,24H,10,12-13H2,1-3H3/t17-,18+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234757
PNG
(US9353104, 51)
Show SMILES Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)c(C)n1
Show InChI InChI=1S/C21H26N6O2/c1-13-5-6-15(14(2)23-13)11-22-19-10-20(25-27(4)21(19)28)29-12-16-9-17(16)18-7-8-26(3)24-18/h5-8,10,16-17,22H,9,11-12H2,1-4H3/t16-,17+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234769
PNG
(US9353104, 64)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ccc(C)nc2)c(=O)n(C)n1
Show InChI InChI=1S/C22H25N5O3/c1-14-4-5-15(10-23-14)11-24-20-9-21(26-27(2)22(20)28)30-13-16-8-18(16)19-7-6-17(29-3)12-25-19/h4-7,9-10,12,16,18,24H,8,11,13H2,1-3H3/t16-,18+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234833
PNG
(US9353104, 138)
Show SMILES CCc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(C)cn3)nn(C)c2=O)n(C)n1
Show InChI InChI=1S/C22H28N6O2/c1-5-16-9-17(27(3)25-16)12-24-20-10-21(26-28(4)22(20)29)30-13-15-8-18(15)19-7-6-14(2)11-23-19/h6-7,9-11,15,18,24H,5,8,12-13H2,1-4H3/t15-,18+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234764
PNG
(US9353104, 58)
Show SMILES Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC(F)F)cn3)nn(C)c2=O)c(C)n1
Show InChI InChI=1S/C23H25F2N5O3/c1-13-4-5-15(14(2)28-13)10-26-20-9-21(29-30(3)22(20)31)32-12-16-8-18(16)19-7-6-17(11-27-19)33-23(24)25/h4-7,9,11,16,18,23,26H,8,10,12H2,1-3H3/t16-,18+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234838
PNG
(US9353104, 144)
Show SMILES CCn1nc(OC[C@H]2C[C@@H]2c2ccc(OC)cn2)cc(NCc2nnc(C)s2)c1=O
Show InChI InChI=1S/C20H24N6O3S/c1-4-26-20(27)17(22-10-19-24-23-12(2)30-19)8-18(25-26)29-11-13-7-15(13)16-6-5-14(28-3)9-21-16/h5-6,8-9,13,15,22H,4,7,10-11H2,1-3H3/t13-,15+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234811
PNG
(US9353104, 115)
Show SMILES Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3cccc(C)n3)nn(C)c2=O)s1
Show InChI InChI=1S/C19H22N6O2S/c1-11-5-4-6-15(21-11)14-7-13(14)10-27-17-8-16(19(26)25(3)24-17)20-9-18-23-22-12(2)28-18/h4-6,8,13-14,20H,7,9-10H2,1-3H3/t13-,14+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234759
PNG
(US9353104, 53)
Show SMILES Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)c(C)n1
Show InChI InChI=1S/C22H24FN5O2/c1-13-4-5-15(14(2)26-13)10-24-20-9-21(27-28(3)22(20)29)30-12-16-8-18(16)19-7-6-17(23)11-25-19/h4-7,9,11,16,18,24H,8,10,12H2,1-3H3/t16-,18+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234814
PNG
(US9353104, 118)
Show SMILES Cc1cnc(CNc2cc(OC[C@H]3C[C@@H]3c3cccc(C)n3)nn(C)c2=O)s1
Show InChI InChI=1S/C20H23N5O2S/c1-12-5-4-6-16(23-12)15-7-14(15)11-27-18-8-17(20(26)25(3)24-18)21-10-19-22-9-13(2)28-19/h4-6,8-9,14-15,21H,7,10-11H2,1-3H3/t14-,15+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234781
PNG
(US9353104, 76)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ccc(C)nn2)c(=O)n(C)n1
Show InChI InChI=1S/C21H24N6O3/c1-13-4-5-15(25-24-13)10-22-19-9-20(26-27(2)21(19)28)30-12-14-8-17(14)18-7-6-16(29-3)11-23-18/h4-7,9,11,14,17,22H,8,10,12H2,1-3H3/t14-,17+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234733
PNG
(US9353104, 21)
Show SMILES Cc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)n(C)n1
Show InChI InChI=1S/C19H25N7O2/c1-12-7-14(25(3)21-12)10-20-17-9-18(23-26(4)19(17)27)28-11-13-8-15(13)16-5-6-24(2)22-16/h5-7,9,13,15,20H,8,10-11H2,1-4H3/t13-,15+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234822
PNG
(US9353104, 127)
Show SMILES Cc1nc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(C)cn3)nn(C)c2=O)sc1C
Show InChI InChI=1S/C21H25N5O2S/c1-12-5-6-17(22-9-12)16-7-15(16)11-28-19-8-18(21(27)26(4)25-19)23-10-20-24-13(2)14(3)29-20/h5-6,8-9,15-16,23H,7,10-11H2,1-4H3/t15-,16+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234740
PNG
(US9353104, 28)
Show SMILES Cc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC(F)F)cn3)nn(C)c2=O)n(C)n1
Show InChI InChI=1S/C21H24F2N6O3/c1-12-6-14(28(2)26-12)9-24-18-8-19(27-29(3)20(18)30)31-11-13-7-16(13)17-5-4-15(10-25-17)32-21(22)23/h4-6,8,10,13,16,21,24H,7,9,11H2,1-3H3/t13-,16+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234840
PNG
(US9353104, 146)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2c[nH]nn2)c(=O)n(C)n1
Show InChI InChI=1S/C18H21N7O3/c1-25-18(26)16(19-7-12-8-21-24-22-12)6-17(23-25)28-10-11-5-14(11)15-4-3-13(27-2)9-20-15/h3-4,6,8-9,11,14,19H,5,7,10H2,1-2H3,(H,21,22,24)/t11-,14+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234821
PNG
(US9353104, 126)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2nc(C)c(C)s2)c(=O)n(C)n1
Show InChI InChI=1S/C21H25N5O3S/c1-12-13(2)30-20(24-12)10-23-18-8-19(25-26(3)21(18)27)29-11-14-7-16(14)17-6-5-15(28-4)9-22-17/h5-6,8-9,14,16,23H,7,10-11H2,1-4H3/t14-,16+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234772
PNG
(US9353104, 67)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cncc(C)c2)c(=O)n(C)n1
Show InChI InChI=1S/C22H25N5O3/c1-14-6-15(10-23-9-14)11-24-20-8-21(26-27(2)22(20)28)30-13-16-7-18(16)19-5-4-17(29-3)12-25-19/h4-6,8-10,12,16,18,24H,7,11,13H2,1-3H3/t16-,18+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234721
PNG
(US9353104, 9)
Show SMILES Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(C)cn3)nn(C)c2=O)nc1
Show InChI InChI=1S/C22H25N5O2/c1-14-4-6-17(23-10-14)12-25-20-9-21(26-27(3)22(20)28)29-13-16-8-18(16)19-7-5-15(2)11-24-19/h4-7,9-11,16,18,25H,8,12-13H2,1-3H3/t16-,18+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234770
PNG
(US9353104, 65)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cccnc2C)c(=O)n(C)n1
Show InChI InChI=1S/C22H25N5O3/c1-14-15(5-4-8-23-14)11-24-20-10-21(26-27(2)22(20)28)30-13-16-9-18(16)19-7-6-17(29-3)12-25-19/h4-8,10,12,16,18,24H,9,11,13H2,1-3H3/t16-,18+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234800
PNG
(US9353104, 104)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cn(C)nc2C(F)(F)F)c(=O)n(C)n1
Show InChI InChI=1S/C21H23F3N6O2/c1-12-4-5-16(25-8-12)15-6-13(15)11-32-18-7-17(20(31)30(3)27-18)26-9-14-10-29(2)28-19(14)21(22,23)24/h4-5,7-8,10,13,15,26H,6,9,11H2,1-3H3/t13-,15+/m1/s1
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0.0560n/an/an/an/an/an/an/an/a



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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234832
PNG
(US9353104, 137)
Show SMILES CCc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC)cn3)nn(C)c2=O)n(C)n1
Show InChI InChI=1S/C22H28N6O3/c1-5-15-9-16(27(2)25-15)11-23-20-10-21(26-28(3)22(20)29)31-13-14-8-18(14)19-7-6-17(30-4)12-24-19/h6-7,9-10,12,14,18,23H,5,8,11,13H2,1-4H3/t14-,18+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234746
PNG
(US9353104, 34)
Show SMILES Cc1ncc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(Cl)cn3)nn(C)c2=O)s1
Show InChI InChI=1S/C19H20ClN5O2S/c1-11-21-8-14(28-11)9-23-17-6-18(24-25(2)19(17)26)27-10-12-5-15(12)16-4-3-13(20)7-22-16/h3-4,6-8,12,15,23H,5,9-10H2,1-2H3/t12-,15+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234841
PNG
(US9353104, 147)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cn(C)nn2)c(=O)n(C)n1
Show InChI InChI=1S/C19H23N7O3/c1-25-10-13(22-24-25)8-20-17-7-18(23-26(2)19(17)27)29-11-12-6-15(12)16-5-4-14(28-3)9-21-16/h4-5,7,9-10,12,15,20H,6,8,11H2,1-3H3/t12-,15+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234722
PNG
(US9353104, 10)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cnn(C)c2)c(=O)n(C)n1
Show InChI InChI=1S/C20H24N6O2/c1-13-4-5-17(21-8-13)16-6-15(16)12-28-19-7-18(20(27)26(3)24-19)22-9-14-10-23-25(2)11-14/h4-5,7-8,10-11,15-16,22H,6,9,12H2,1-3H3/t15-,16+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234720
PNG
(US9353104, 8)
Show SMILES COc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(C)cn3)nn(C)c2=O)cc1
Show InChI InChI=1S/C23H26N4O3/c1-15-4-9-20(24-12-15)19-10-17(19)14-30-22-11-21(23(28)27(2)26-22)25-13-16-5-7-18(29-3)8-6-16/h4-9,11-12,17,19,25H,10,13-14H2,1-3H3/t17-,19+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234806
PNG
(US9353104, 110)
Show SMILES Cc1ncc(CNc2cc(OC[C@@H]3C[C@H]3c3nn(C)c4ccccc34)nn(C)c2=O)s1
Show InChI InChI=1S/C22H24N6O2S/c1-13-23-10-15(31-13)11-24-18-9-20(25-28(3)22(18)29)30-12-14-8-17(14)21-16-6-4-5-7-19(16)27(2)26-21/h4-7,9-10,14,17,24H,8,11-12H2,1-3H3/t14-,17+/m0/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234737
PNG
(US9353104, 25)
Show SMILES Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(Cl)cn3)nn(C)c2=O)s1
Show InChI InChI=1S/C18H19ClN6O2S/c1-10-22-23-17(28-10)8-21-15-6-16(24-25(2)18(15)26)27-9-11-5-13(11)14-4-3-12(19)7-20-14/h3-4,6-7,11,13,21H,5,8-9H2,1-2H3/t11-,13+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234813
PNG
(US9353104, 117)
Show SMILES Cc1cccc(n1)[C@H]1C[C@@H]1COc1cc(NCc2cnn(C)c2)c(=O)n(C)n1
Show InChI InChI=1S/C20H24N6O2/c1-13-5-4-6-17(23-13)16-7-15(16)12-28-19-8-18(20(27)26(3)24-19)21-9-14-10-22-25(2)11-14/h4-6,8,10-11,15-16,21H,7,9,12H2,1-3H3/t15-,16+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234714
PNG
(US9353104, 2)
Show SMILES Cc1ncc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)s1
Show InChI InChI=1S/C18H22N6O2S/c1-11-19-8-13(27-11)9-20-16-7-17(22-24(3)18(16)25)26-10-12-6-14(12)15-4-5-23(2)21-15/h4-5,7-8,12,14,20H,6,9-10H2,1-3H3/t12-,14+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234738
PNG
(US9353104, 26)
Show SMILES Cc1cnc(CNc2cc(OC[C@H]3CC3c3ccn(C)n3)nn(C)c2=O)s1
Show InChI InChI=1S/C18H22N6O2S/c1-11-8-20-17(27-11)9-19-15-7-16(22-24(3)18(15)25)26-10-12-6-13(12)14-4-5-23(2)21-14/h4-5,7-8,12-13,19H,6,9-10H2,1-3H3/t12-,13?/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234730
PNG
(US9353104, 18)
Show SMILES Cc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)n(C)n1
Show InChI InChI=1S/C20H23FN6O2/c1-12-6-15(26(2)24-12)10-23-18-8-19(25-27(3)20(18)28)29-11-13-7-16(13)17-5-4-14(21)9-22-17/h4-6,8-9,13,16,23H,7,10-11H2,1-3H3/t13-,16+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234718
PNG
(US9353104, 6)
Show SMILES Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)s1
Show InChI InChI=1S/C17H21N7O2S/c1-10-19-20-16(27-10)8-18-14-7-15(22-24(3)17(14)25)26-9-11-6-12(11)13-4-5-23(2)21-13/h4-5,7,11-12,18H,6,8-9H2,1-3H3/t11-,12+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234741
PNG
(US9353104, 29)
Show SMILES Cc1ncc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC(F)F)cn3)nn(C)c2=O)s1
Show InChI InChI=1S/C20H21F2N5O3S/c1-11-23-8-14(31-11)9-25-17-6-18(26-27(2)19(17)28)29-10-12-5-15(12)16-4-3-13(7-24-16)30-20(21)22/h3-4,6-8,12,15,20,25H,5,9-10H2,1-2H3/t12-,15+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234810
PNG
(US9353104, 114)
Show SMILES Cc1cnc(CNc2cc(OC[C@@H]3C[C@H]3c3nn(C)c4ccccc34)nn(C)c2=O)s1
Show InChI InChI=1S/C22H24N6O2S/c1-13-10-24-20(31-13)11-23-17-9-19(25-28(3)22(17)29)30-12-14-8-16(14)21-15-6-4-5-7-18(15)27(2)26-21/h4-7,9-10,14,16,23H,8,11-12H2,1-3H3/t14-,16+/m0/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234723
PNG
(US9353104, 11)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ccc(C)nc2)c(=O)n(C)n1
Show InChI InChI=1S/C22H25N5O2/c1-14-4-7-19(24-10-14)18-8-17(18)13-29-21-9-20(22(28)27(3)26-21)25-12-16-6-5-15(2)23-11-16/h4-7,9-11,17-18,25H,8,12-13H2,1-3H3/t17-,18+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234767
PNG
(US9353104, 62)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ccnc(C)c2)c(=O)n(C)n1
Show InChI InChI=1S/C22H25N5O3/c1-14-8-15(6-7-23-14)11-24-20-10-21(26-27(2)22(20)28)30-13-16-9-18(16)19-5-4-17(29-3)12-25-19/h4-8,10,12,16,18,24H,9,11,13H2,1-3H3/t16-,18+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234795
PNG
(US9353104, 99)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ccnn2C)c(=O)n(C)n1
Show InChI InChI=1S/C20H24N6O2/c1-13-4-5-17(21-10-13)16-8-14(16)12-28-19-9-18(20(27)26(3)24-19)22-11-15-6-7-23-25(15)2/h4-7,9-10,14,16,22H,8,11-12H2,1-3H3/t14-,16+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234803
PNG
(US9353104, 107)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cnn(c2)C(F)F)c(=O)n(C)n1
Show InChI InChI=1S/C20H22F2N6O3/c1-27-19(29)17(23-7-12-8-25-28(10-12)20(21)22)6-18(26-27)31-11-13-5-15(13)16-4-3-14(30-2)9-24-16/h3-4,6,8-10,13,15,20,23H,5,7,11H2,1-2H3/t13-,15+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234717
PNG
(US9353104, 5)
Show SMILES Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC(F)F)cn3)nn(C)c2=O)s1
Show InChI InChI=1S/C19H20F2N6O3S/c1-10-24-25-17(31-10)8-23-15-6-16(26-27(2)18(15)28)29-9-11-5-13(11)14-4-3-12(7-22-14)30-19(20)21/h3-4,6-7,11,13,19,23H,5,8-9H2,1-2H3/t11-,13+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234734
PNG
(US9353104, 22)
Show SMILES Cc1ncc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)s1
Show InChI InChI=1S/C19H20FN5O2S/c1-11-21-8-14(28-11)9-23-17-6-18(24-25(2)19(17)26)27-10-12-5-15(12)16-4-3-13(20)7-22-16/h3-4,6-8,12,15,23H,5,9-10H2,1-2H3/t12-,15+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234744
PNG
(US9353104, 32)
Show SMILES Cc1cnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)s1
Show InChI InChI=1S/C19H20FN5O2S/c1-11-7-23-18(28-11)9-22-16-6-17(24-25(2)19(16)26)27-10-12-5-14(12)15-4-3-13(20)8-21-15/h3-4,6-8,12,14,22H,5,9-10H2,1-2H3/t12-,14+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234796
PNG
(US9353104, 100)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ccnn2C)c(=O)n(C)n1
Show InChI InChI=1S/C20H24N6O3/c1-25-14(6-7-23-25)10-21-18-9-19(24-26(2)20(18)27)29-12-13-8-16(13)17-5-4-15(28-3)11-22-17/h4-7,9,11,13,16,21H,8,10,12H2,1-3H3/t13-,16+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234809
PNG
(US9353104, 113)
Show SMILES Cn1cc(CNc2cc(OC[C@@H]3C[C@H]3c3nn(C)c4ccccc34)nn(C)c2=O)cn1
Show InChI InChI=1S/C22H25N7O2/c1-27-12-14(11-24-27)10-23-18-9-20(25-29(3)22(18)30)31-13-15-8-17(15)21-16-6-4-5-7-19(16)28(2)26-21/h4-7,9,11-12,15,17,23H,8,10,13H2,1-3H3/t15-,17+/m0/s1
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0.197n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234830
PNG
(US9353104, 135)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cccnc2)c(=O)n(C)n1
Show InChI InChI=1S/C21H23N5O3/c1-26-21(27)19(23-11-14-4-3-7-22-10-14)9-20(25-26)29-13-15-8-17(15)18-6-5-16(28-2)12-24-18/h3-7,9-10,12,15,17,23H,8,11,13H2,1-2H3/t15-,17+/m1/s1
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0.261n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234801
PNG
(US9353104, 105)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cc(C)ccn2)c(=O)n(C)n1
Show InChI InChI=1S/C22H25N5O3/c1-14-6-7-23-16(8-14)11-24-20-10-21(26-27(2)22(20)28)30-13-15-9-18(15)19-5-4-17(29-3)12-25-19/h4-8,10,12,15,18,24H,9,11,13H2,1-3H3/t15-,18+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234834
PNG
(US9353104, 139)
Show SMILES CCc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)n(C)n1
Show InChI InChI=1S/C20H27N7O2/c1-5-14-9-15(26(3)22-14)11-21-18-10-19(24-27(4)20(18)28)29-12-13-8-16(13)17-6-7-25(2)23-17/h6-7,9-10,13,16,21H,5,8,11-12H2,1-4H3/t13-,16+/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234739
PNG
(US9353104, 27)
Show SMILES Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(Cl)cn3)nn(C)c2=O)cn1
Show InChI InChI=1S/C19H21ClN6O2/c1-25-10-12(8-23-25)7-21-17-6-18(24-26(2)19(17)27)28-11-13-5-15(13)16-4-3-14(20)9-22-16/h3-4,6,8-10,13,15,21H,5,7,11H2,1-2H3/t13-,15+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234823
PNG
(US9353104, 128)
Show SMILES Cc1nc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)sc1C
Show InChI InChI=1S/C19H24N6O2S/c1-11-12(2)28-18(21-11)9-20-16-8-17(23-25(4)19(16)26)27-10-13-7-14(13)15-5-6-24(3)22-15/h5-6,8,13-14,20H,7,9-10H2,1-4H3/t13-,14+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234765
PNG
(US9353104, 59)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2c(C)noc2C)c(=O)n(C)n1
Show InChI InChI=1S/C21H25N5O4/c1-12-17(13(2)30-25-12)10-23-19-8-20(24-26(3)21(19)27)29-11-14-7-16(14)18-6-5-15(28-4)9-22-18/h5-6,8-9,14,16,23H,7,10-11H2,1-4H3/t14-,16+/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234774
PNG
(US9353104, 69)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ccc(C)c(C)n2)c(=O)n(C)n1
Show InChI InChI=1S/C23H27N5O3/c1-14-5-6-17(26-15(14)2)11-24-21-10-22(27-28(3)23(21)29)31-13-16-9-19(16)20-8-7-18(30-4)12-25-20/h5-8,10,12,16,19,24H,9,11,13H2,1-4H3/t16-,19+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234736
PNG
(US9353104, 24)
Show SMILES Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)nc1
Show InChI InChI=1S/C20H24N6O2/c1-13-4-5-15(21-10-13)11-22-18-9-19(24-26(3)20(18)27)28-12-14-8-16(14)17-6-7-25(2)23-17/h4-7,9-10,14,16,22H,8,11-12H2,1-3H3/t14-,16+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234747
PNG
(US9353104, 35)
Show SMILES Cc1nn(C)c(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(C)cn3)nn(C)c2=O)c1Cl
Show InChI InChI=1S/C21H25ClN6O2/c1-12-5-6-16(23-9-12)15-7-14(15)11-30-19-8-17(21(29)28(4)26-19)24-10-18-20(22)13(2)25-27(18)3/h5-6,8-9,14-15,24H,7,10-11H2,1-4H3/t14-,15+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234735
PNG
(US9353104, 23)
Show SMILES Cn1ccc(n1)[C@H]1C[C@@H]1COc1cc(NCc2cnn(C)c2)c(=O)n(C)n1
Show InChI InChI=1S/C18H23N7O2/c1-23-5-4-15(21-23)14-6-13(14)11-27-17-7-16(18(26)25(3)22-17)19-8-12-9-20-24(2)10-12/h4-5,7,9-10,13-14,19H,6,8,11H2,1-3H3/t13-,14+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234729
PNG
(US9353104, 17)
Show SMILES COc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)cc1
Show InChI InChI=1S/C21H25N5O3/c1-25-9-8-18(23-25)17-10-15(17)13-29-20-11-19(21(27)26(2)24-20)22-12-14-4-6-16(28-3)7-5-14/h4-9,11,15,17,22H,10,12-13H2,1-3H3/t15-,17+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234719
PNG
(US9353104, 7)
Show SMILES Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)s1
Show InChI InChI=1S/C18H19FN6O2S/c1-10-22-23-17(28-10)8-21-15-6-16(24-25(2)18(15)26)27-9-11-5-13(11)14-4-3-12(19)7-20-14/h3-4,6-7,11,13,21H,5,8-9H2,1-2H3/t11-,13+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234742
PNG
(US9353104, 30)
Show SMILES Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC(F)F)cn3)nn(C)c2=O)cn1
Show InChI InChI=1S/C20H22F2N6O3/c1-27-10-12(8-25-27)7-23-17-6-18(26-28(2)19(17)29)30-11-13-5-15(13)16-4-3-14(9-24-16)31-20(21)22/h3-4,6,8-10,13,15,20,23H,5,7,11H2,1-2H3/t13-,15+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234842
PNG
(US9353104, 148)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cnn(C)n2)c(=O)n(C)n1
Show InChI InChI=1S/C19H23N7O3/c1-25-19(27)17(20-8-13-9-22-26(2)23-13)7-18(24-25)29-11-12-6-15(12)16-5-4-14(28-3)10-21-16/h4-5,7,9-10,12,15,20H,6,8,11H2,1-3H3/t12-,15+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234829
PNG
(US9353104, 134)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ccccn2)c(=O)n(C)n1
Show InChI InChI=1S/C21H23N5O3/c1-26-21(27)19(23-11-15-5-3-4-8-22-15)10-20(25-26)29-13-14-9-17(14)18-7-6-16(28-2)12-24-18/h3-8,10,12,14,17,23H,9,11,13H2,1-2H3/t14-,17+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234728
PNG
(US9353104, 16)
Show SMILES Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)nc1
Show InChI InChI=1S/C21H22FN5O2/c1-13-3-5-16(23-9-13)11-25-19-8-20(26-27(2)21(19)28)29-12-14-7-17(14)18-6-4-15(22)10-24-18/h3-6,8-10,14,17,25H,7,11-12H2,1-2H3/t14-,17+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234732
PNG
(US9353104, 20)
Show SMILES Cc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)cn1
Show InChI InChI=1S/C20H24N6O2/c1-13-4-5-14(10-21-13)11-22-18-9-19(24-26(3)20(18)27)28-12-15-8-16(15)17-6-7-25(2)23-17/h4-7,9-10,15-16,22H,8,11-12H2,1-3H3/t15-,16+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234804
PNG
(US9353104, 108)
Show SMILES Cc1nnc(CNc2cc(OC[C@H]3C[C@@H]3c3nn(C)c4ccccc34)nn(C)c2=O)s1
Show InChI InChI=1S/C21H23N7O2S/c1-12-23-24-19(31-12)10-22-16-9-18(25-28(3)21(16)29)30-11-13-8-15(13)20-14-6-4-5-7-17(14)27(2)26-20/h4-7,9,13,15,22H,8,10-11H2,1-3H3/t13-,15+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234748
PNG
(US9353104, 36)
Show SMILES CN(Cc1nnc(C)s1)c1cc(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)nn(C)c1=O
Show InChI InChI=1S/C23H24N6O2S/c1-14-25-26-22(32-14)12-28(2)20-11-21(27-29(3)23(20)30)31-13-16-10-17(16)19-9-8-15-6-4-5-7-18(15)24-19/h4-9,11,16-17H,10,12-13H2,1-3H3/t16-,17+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234783
PNG
(US9353104, 79)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cnn3ccccc23)c(=O)n(C)n1
Show InChI InChI=1S/C23H24N6O2/c1-15-6-7-19(24-11-15)18-9-16(18)14-31-22-10-20(23(30)28(2)27-22)25-12-17-13-26-29-8-4-3-5-21(17)29/h3-8,10-11,13,16,18,25H,9,12,14H2,1-2H3/t16-,18+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234731
PNG
(US9353104, 19)
Show SMILES Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)cn1
Show InChI InChI=1S/C19H21FN6O2/c1-25-10-12(8-23-25)7-21-17-6-18(24-26(2)19(17)27)28-11-13-5-15(13)16-4-3-14(20)9-22-16/h3-4,6,8-10,13,15,21H,5,7,11H2,1-2H3/t13-,15+/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234792
PNG
(US9353104, 96)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cnn(C)c2Cl)c(=O)n(C)n1
Show InChI InChI=1S/C20H23ClN6O3/c1-26-19(21)13(9-24-26)8-22-17-7-18(25-27(2)20(17)28)30-11-12-6-15(12)16-5-4-14(29-3)10-23-16/h4-5,7,9-10,12,15,22H,6,8,11H2,1-3H3/t12-,15+/m1/s1
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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234727
PNG
(US9353104, 15)
Show SMILES COc1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(F)cn3)nn(C)c2=O)cc1
Show InChI InChI=1S/C22H23FN4O3/c1-27-22(28)20(24-11-14-3-6-17(29-2)7-4-14)10-21(26-27)30-13-15-9-18(15)19-8-5-16(23)12-25-19/h3-8,10,12,15,18,24H,9,11,13H2,1-2H3/t15-,18+/m1/s1
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1.29n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234816
PNG
(US9353104, 120)
Show SMILES Cc1cccc(n1)[C@H]1C[C@@H]1COc1cc(NCc2cccnc2)c(=O)n(C)n1
Show InChI InChI=1S/C21H23N5O2/c1-14-5-3-7-18(24-14)17-9-16(17)13-28-20-10-19(21(27)26(2)25-20)23-12-15-6-4-8-22-11-15/h3-8,10-11,16-17,23H,9,12-13H2,1-2H3/t16-,17+/m1/s1
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1.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234780
PNG
(US9353104, 75)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ccc(Cl)c(C)n2)c(=O)n(C)n1
Show InChI InChI=1S/C22H24ClN5O3/c1-13-18(23)6-4-15(26-13)10-24-20-9-21(27-28(2)22(20)29)31-12-14-8-17(14)19-7-5-16(30-3)11-25-19/h4-7,9,11,14,17,24H,8,10,12H2,1-3H3/t14-,17+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234808
PNG
(US9353104, 112)
Show SMILES Cc1cnc(CNc2cc(OC[C@H]3C[C@@H]3c3nn(C)c4ccccc34)nn(C)c2=O)s1
Show InChI InChI=1S/C22H24N6O2S/c1-13-10-24-20(31-13)11-23-17-9-19(25-28(3)22(17)29)30-12-14-8-16(14)21-15-6-4-5-7-18(15)27(2)26-21/h4-7,9-10,14,16,23H,8,11-12H2,1-3H3/t14-,16+/m1/s1
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1.40n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234794
PNG
(US9353104, 98)
Show SMILES Cn1ccc(n1)[C@H]1C[C@@H]1COc1cc(NCc2ccnn2C)c(=O)n(C)n1
Show InChI InChI=1S/C18H23N7O2/c1-23-7-5-15(21-23)14-8-12(14)11-27-17-9-16(18(26)25(3)22-17)19-10-13-4-6-20-24(13)2/h4-7,9,12,14,19H,8,10-11H2,1-3H3/t12-,14+/m1/s1
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1.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234750
PNG
(US9353104, 38)
Show SMILES Cc1nn(C)c(Cl)c1CNc1cc(OC[C@H]2C[C@@H]2c2ccc(C)cn2)nn(C)c1=O
Show InChI InChI=1S/C21H25ClN6O2/c1-12-5-6-17(23-9-12)15-7-14(15)11-30-19-8-18(21(29)28(4)26-19)24-10-16-13(2)25-27(3)20(16)22/h5-6,8-9,14-15,24H,7,10-11H2,1-4H3/t14-,15+/m1/s1
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1.53n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234751
PNG
(US9353104, 39)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2c(C)nn(C)c2Cl)c(=O)n(C)n1
Show InChI InChI=1S/C21H25ClN6O3/c1-12-16(20(22)27(2)25-12)10-24-18-8-19(26-28(3)21(18)29)31-11-13-7-15(13)17-6-5-14(30-4)9-23-17/h5-6,8-9,13,15,24H,7,10-11H2,1-4H3/t13-,15+/m1/s1
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1.58n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234768
PNG
(US9353104, 63)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cncnc2)c(=O)n(C)n1
Show InChI InChI=1S/C20H22N6O3/c1-26-20(27)18(23-9-13-7-21-12-22-8-13)6-19(25-26)29-11-14-5-16(14)17-4-3-15(28-2)10-24-17/h3-4,6-8,10,12,14,16,23H,5,9,11H2,1-2H3/t14-,16+/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234807
PNG
(US9353104, 111)
Show SMILES Cn1cc(CNc2cc(OC[C@H]3C[C@@H]3c3nn(C)c4ccccc34)nn(C)c2=O)cn1
Show InChI InChI=1S/C22H25N7O2/c1-27-12-14(11-24-27)10-23-18-9-20(25-29(3)22(18)30)31-13-15-8-17(15)21-16-6-4-5-7-19(16)28(2)26-21/h4-7,9,11-12,15,17,23H,8,10,13H2,1-3H3/t15-,17+/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234805
PNG
(US9353104, 109)
Show SMILES Cc1ncc(CNc2cc(OC[C@H]3C[C@@H]3c3nn(C)c4ccccc34)nn(C)c2=O)s1
Show InChI InChI=1S/C22H24N6O2S/c1-13-23-10-15(31-13)11-24-18-9-20(25-28(3)22(18)29)30-12-14-8-17(14)21-16-6-4-5-7-19(16)27(2)26-21/h4-7,9-10,14,17,24H,8,11-12H2,1-3H3/t14-,17+/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234793
PNG
(US9353104, 97)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cccc(C)n2)c(=O)n(C)n1
Show InChI InChI=1S/C22H25N5O3/c1-14-5-4-6-16(25-14)11-23-20-10-21(26-27(2)22(20)28)30-13-15-9-18(15)19-8-7-17(29-3)12-24-19/h4-8,10,12,15,18,23H,9,11,13H2,1-3H3/t15-,18+/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234788
PNG
(US9353104, 88)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2nc(C)nn2C)c(=O)n(C)n1
Show InChI InChI=1S/C20H25N7O3/c1-12-23-18(26(2)24-12)10-22-17-8-19(25-27(3)20(17)28)30-11-13-7-15(13)16-6-5-14(29-4)9-21-16/h5-6,8-9,13,15,22H,7,10-11H2,1-4H3/t13-,15+/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234815
PNG
(US9353104, 119)
Show SMILES Cc1cccc(n1)[C@H]1C[C@@H]1COc1cc(NCc2ccccn2)c(=O)n(C)n1
Show InChI InChI=1S/C21H23N5O2/c1-14-6-5-8-18(24-14)17-10-15(17)13-28-20-11-19(21(27)26(2)25-20)23-12-16-7-3-4-9-22-16/h3-9,11,15,17,23H,10,12-13H2,1-2H3/t15-,17+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234824
PNG
(US9353104, 129)
Show SMILES Cc1cc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)nn1C
Show InChI InChI=1S/C19H25N7O2/c1-12-7-14(21-25(12)3)10-20-17-9-18(23-26(4)19(17)27)28-11-13-8-15(13)16-5-6-24(2)22-16/h5-7,9,13,15,20H,8,10-11H2,1-4H3/t13-,15+/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234766
PNG
(US9353104, 61)
Show SMILES Cc1noc(C)c1CNc1cc(OC[C@H]2C[C@@H]2c2ccn(C)n2)nn(C)c1=O
Show InChI InChI=1S/C19H24N6O3/c1-11-15(12(2)28-23-11)9-20-17-8-18(22-25(4)19(17)26)27-10-13-7-14(13)16-5-6-24(3)21-16/h5-6,8,13-14,20H,7,9-10H2,1-4H3/t13-,14+/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234779
PNG
(US9353104, 74)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ccc(F)c(C)n2)c(=O)n(C)n1
Show InChI InChI=1S/C22H24FN5O3/c1-13-18(23)6-4-15(26-13)10-24-20-9-21(27-28(2)22(20)29)31-12-14-8-17(14)19-7-5-16(30-3)11-25-19/h4-7,9,11,14,17,24H,8,10,12H2,1-3H3/t14-,17+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234782
PNG
(US9353104, 77)
Show SMILES COc1ccc(Cn2cc(CNc3cc(OC[C@H]4C[C@@H]4c4ccc(OC)cn4)nn(C)c3=O)c(C)n2)cc1
Show InChI InChI=1S/C28H32N6O4/c1-18-21(16-34(31-18)15-19-5-7-22(36-3)8-6-19)13-29-26-12-27(32-33(2)28(26)35)38-17-20-11-24(20)25-10-9-23(37-4)14-30-25/h5-10,12,14,16,20,24,29H,11,13,15,17H2,1-4H3/t20-,24+/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234771
PNG
(US9353104, 66)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cnccn2)c(=O)n(C)n1
Show InChI InChI=1S/C20H22N6O3/c1-26-20(27)18(23-10-14-9-21-5-6-22-14)8-19(25-26)29-12-13-7-16(13)17-4-3-15(28-2)11-24-17/h3-6,8-9,11,13,16,23H,7,10,12H2,1-2H3/t13-,16+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234802
PNG
(US9353104, 106)
Show SMILES CCn1ccc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(OC)cn3)nn(C)c2=O)n1
Show InChI InChI=1S/C21H26N6O3/c1-4-27-8-7-15(24-27)11-22-19-10-20(25-26(2)21(19)28)30-13-14-9-17(14)18-6-5-16(29-3)12-23-18/h5-8,10,12,14,17,22H,4,9,11,13H2,1-3H3/t14-,17+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234790
PNG
(US9353104, 91)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(N(Cc2ccc(C)nc2C)Cc2ccc(C)nc2C)c(=O)n(C)n1
Show InChI InChI=1S/C31H36N6O3/c1-19-7-9-23(21(3)33-19)16-37(17-24-10-8-20(2)34-22(24)4)29-14-30(35-36(5)31(29)38)40-18-25-13-27(25)28-12-11-26(39-6)15-32-28/h7-12,14-15,25,27H,13,16-18H2,1-6H3/t25-,27+/m1/s1
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234839
PNG
(US9353104, 145)
Show SMILES COc1ccc(CN(CC#C)c2cc(OC[C@H]3C[C@@H]3c3ccc(OC)cn3)nn(C)c2=O)cc1
Show InChI InChI=1S/C26H28N4O4/c1-5-12-30(16-18-6-8-20(32-3)9-7-18)24-14-25(28-29(2)26(24)31)34-17-19-13-22(19)23-11-10-21(33-4)15-27-23/h1,6-11,14-15,19,22H,12-13,16-17H2,2-4H3/t19-,22+/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234753
PNG
(US9353104, 47)
Show SMILES Cn1ccc(n1)[C@H]1C[C@@H]1COc1cc(NCc2nccs2)c(=O)n(C)n1
Show InChI InChI=1S/C17H20N6O2S/c1-22-5-3-13(20-22)12-7-11(12)10-25-15-8-14(17(24)23(2)21-15)19-9-16-18-4-6-26-16/h3-6,8,11-12,19H,7,9-10H2,1-2H3/t11-,12+/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234786
PNG
(US9353104, 86)
Show SMILES Cc1cnn(C)c1CNc1cc(OC[C@H]2C[C@@H]2c2ccn(C)n2)nn(C)c1=O
Show InChI InChI=1S/C19H25N7O2/c1-12-9-21-25(3)17(12)10-20-16-8-18(23-26(4)19(16)27)28-11-13-7-14(13)15-5-6-24(2)22-15/h5-6,8-9,13-14,20H,7,10-11H2,1-4H3/t13-,14+/m1/s1
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9.40n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234724
PNG
(US9353104, 12)
Show SMILES Cc1csc(CNc2cc(OC[C@H]3C[C@@H]3c3ccc(C)cn3)nn(C)c2=O)n1
Show InChI InChI=1S/C20H23N5O2S/c1-12-4-5-16(21-8-12)15-6-14(15)10-27-18-7-17(20(26)25(3)24-18)22-9-19-23-13(2)11-28-19/h4-5,7-8,11,14-15,22H,6,9-10H2,1-3H3/t14-,15+/m1/s1
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9.89n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234831
PNG
(US9353104, 136)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCCc2nccs2)c(=O)n(C)n1
Show InChI InChI=1S/C20H23N5O3S/c1-25-20(26)17(21-6-5-19-22-7-8-29-19)10-18(24-25)28-12-13-9-15(13)16-4-3-14(27-2)11-23-16/h3-4,7-8,10-11,13,15,21H,5-6,9,12H2,1-2H3/t13-,15+/m1/s1
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10.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234773
PNG
(US9353104, 68)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cnccc2C)c(=O)n(C)n1
Show InChI InChI=1S/C22H25N5O3/c1-14-6-7-23-10-16(14)11-24-20-9-21(26-27(2)22(20)28)30-13-15-8-18(15)19-5-4-17(29-3)12-25-19/h4-7,9-10,12,15,18,24H,8,11,13H2,1-3H3/t15-,18+/m1/s1
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11.6n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234752
PNG
(US9353104, 40)
Show SMILES Cc1nn(C)c(Cl)c1CNc1cc(OC[C@H]2C[C@@H]2c2ccn(C)n2)nn(C)c1=O
Show InChI InChI=1S/C19H24ClN7O2/c1-11-14(18(20)26(3)22-11)9-21-16-8-17(24-27(4)19(16)28)29-10-12-7-13(12)15-5-6-25(2)23-15/h5-6,8,12-13,21H,7,9-10H2,1-4H3/t12-,13+/m1/s1
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11.8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234755
PNG
(US9353104, 49)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2csc(C)n2)c(=O)n(C)n1
Show InChI InChI=1S/C20H23N5O3S/c1-12-23-14(11-29-12)8-21-18-7-19(24-25(2)20(18)26)28-10-13-6-16(13)17-5-4-15(27-3)9-22-17/h4-5,7,9,11,13,16,21H,6,8,10H2,1-3H3/t13-,16+/m1/s1
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16.6n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234778
PNG
(US9353104, 73)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ncccc2C)c(=O)n(C)n1
Show InChI InChI=1S/C22H25N5O3/c1-14-5-4-8-23-20(14)12-25-19-10-21(26-27(2)22(19)28)30-13-15-9-17(15)18-7-6-16(29-3)11-24-18/h4-8,10-11,15,17,25H,9,12-13H2,1-3H3/t15-,17+/m1/s1
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32.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234785
PNG
(US9353104, 83)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2cnn(C)c2N(C)C)c(=O)n(C)n1
Show InChI InChI=1S/C22H29N7O3/c1-27(2)21-15(11-25-28(21)3)10-23-19-9-20(26-29(4)22(19)30)32-13-14-8-17(14)18-7-6-16(31-5)12-24-18/h6-7,9,11-12,14,17,23H,8,10,13H2,1-5H3/t14-,17+/m1/s1
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42.6n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234776
PNG
(US9353104, 71)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2nc(C)ccc2C)c(=O)n(C)n1
Show InChI InChI=1S/C23H27N5O3/c1-14-5-6-15(2)26-21(14)12-25-20-10-22(27-28(3)23(20)29)31-13-16-9-18(16)19-8-7-17(30-4)11-24-19/h5-8,10-11,16,18,25H,9,12-13H2,1-4H3/t16-,18+/m1/s1
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48.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234798
PNG
(US9353104, 102)
Show SMILES Cc1cc(C(=O)Nc2cc(OC[C@H]3C[C@@H]3c3ccc(C)cn3)nn(C)c2=O)n(C)n1
Show InChI InChI=1S/C21H24N6O3/c1-12-5-6-16(22-10-12)15-8-14(15)11-30-19-9-17(21(29)27(4)25-19)23-20(28)18-7-13(2)24-26(18)3/h5-7,9-10,14-15H,8,11H2,1-4H3,(H,23,28)/t14-,15+/m1/s1
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51.2n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234775
PNG
(US9353104, 70)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2nc(C)ccc2F)c(=O)n(C)n1
Show InChI InChI=1S/C22H24FN5O3/c1-13-4-6-17(23)20(26-13)11-25-19-9-21(27-28(2)22(19)29)31-12-14-8-16(14)18-7-5-15(30-3)10-24-18/h4-7,9-10,14,16,25H,8,11-12H2,1-3H3/t14-,16+/m1/s1
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55.1n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234799
PNG
(US9353104, 103)
Show SMILES Cc1cc(C(=O)Nc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)n(C)n1
Show InChI InChI=1S/C19H23N7O3/c1-11-7-16(25(3)21-11)18(27)20-15-9-17(23-26(4)19(15)28)29-10-12-8-13(12)14-5-6-24(2)22-14/h5-7,9,12-13H,8,10H2,1-4H3,(H,20,27)/t12-,13+/m1/s1
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75n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234784
PNG
(US9353104, 82)
Show SMILES CN(C)c1c(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)cnn1C
Show InChI InChI=1S/C20H28N8O2/c1-25(2)19-14(11-22-27(19)4)10-21-17-9-18(24-28(5)20(17)29)30-12-13-8-15(13)16-6-7-26(3)23-16/h6-7,9,11,13,15,21H,8,10,12H2,1-5H3/t13-,15+/m1/s1
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75n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234797
PNG
(US9353104, 101)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NC(=O)c2cc(C)nn2C)c(=O)n(C)n1
Show InChI InChI=1S/C21H24N6O4/c1-12-7-18(26(2)24-12)20(28)23-17-9-19(25-27(3)21(17)29)31-11-13-8-15(13)16-6-5-14(30-4)10-22-16/h5-7,9-10,13,15H,8,11H2,1-4H3,(H,23,28)/t13-,15+/m1/s1
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75n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234791
PNG
(US9353104, 95)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NC(=O)c2cnn(C)c2Cl)c(=O)n(C)n1
Show InChI InChI=1S/C20H21ClN6O4/c1-26-18(21)14(9-23-26)19(28)24-16-7-17(25-27(2)20(16)29)31-10-11-6-13(11)15-5-4-12(30-3)8-22-15/h4-5,7-9,11,13H,6,10H2,1-3H3,(H,24,28)/t11-,13+/m1/s1
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75n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234837
PNG
(US9353104, 142)
Show SMILES COc1ccc(Cn2nc(OC[C@H]3C[C@@H]3c3ccc(OC)cn3)cc(NCc3nnc(C)s3)c2=O)cc1
Show InChI InChI=1S/C26H28N6O4S/c1-16-29-30-25(37-16)13-28-23-11-24(31-32(26(23)33)14-17-4-6-19(34-2)7-5-17)36-15-18-10-21(18)22-9-8-20(35-3)12-27-22/h4-9,11-12,18,21,28H,10,13-15H2,1-3H3/t18-,21+/m1/s1
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75n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM234754
PNG
(US9353104, 48)
Show SMILES Cc1nc(CNc2cc(OC[C@H]3C[C@@H]3c3ccn(C)n3)nn(C)c2=O)cs1
Show InChI InChI=1S/C18H22N6O2S/c1-11-20-13(10-27-11)8-19-16-7-17(22-24(3)18(16)25)26-9-12-6-14(12)15-4-5-23(2)21-15/h4-5,7,10,12,14,19H,6,8-9H2,1-3H3/t12-,14+/m1/s1
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>100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%