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Patent code US9359338

Compile Data Set for Download or QSAR

Found 366 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM235541
PNG
(US9359338, Exe. 151)
Show SMILES FC1(F)CCOc2ccc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3)cc12
Show InChI InChI=1S/C25H22F2N4O4/c26-25(27)10-12-34-21-8-5-17(13-20(21)25)30-24(33)29-16-3-6-18(7-4-16)35-19-9-11-28-22(14-19)31-23(32)15-1-2-15/h3-9,11,13-15H,1-2,10,12H2,(H,28,31,32)(H2,29,30,33)
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n/an/a 3.30n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use ADP-GLO™ assay kit from Promega to evaluate the inhibitory activity of compounds at B-Raf. [Instrument]: PerKinElmer...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM235412
PNG
(US9359338, Exe. 022 | US9359338, Exe. 027)
Show SMILES Fc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C23H17ClF4N4O3/c24-17-5-3-13(9-16(17)23(26,27)28)30-22(34)31-14-4-6-19(18(25)10-14)35-15-7-8-29-20(11-15)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34)
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n/an/a 3.60n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use ADP-GLO™ assay kit from Promega to evaluate the inhibitory activity of compounds at B-Raf. [Instrument]: PerKinElmer...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM235627
PNG
(US9359338, Exe. 237)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)cc(OCC2CNC2)c1
Show InChI InChI=1S/C27H26F3N5O4/c28-27(29,30)18-9-20(11-23(10-18)38-15-16-13-31-14-16)34-26(37)33-19-3-5-21(6-4-19)39-22-7-8-32-24(12-22)35-25(36)17-1-2-17/h3-12,16-17,31H,1-2,13-15H2,(H,32,35,36)(H2,33,34,37)
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n/an/a 3.70n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use ADP-GLO™ assay kit from Promega to evaluate the inhibitory activity of compounds at B-Raf. [Instrument]: PerKinElmer...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235451
PNG
(US9359338, Exe. 061)
Show SMILES Fc1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C23H18F4N4O3/c24-18-11-16(30-22(33)29-15-3-1-2-14(10-15)23(25,26)27)6-7-19(18)34-17-8-9-28-20(12-17)31-21(32)13-4-5-13/h1-3,6-13H,4-5H2,(H,28,31,32)(H2,29,30,33)
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n/an/a 3.73n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235419
PNG
(US9359338, Exe. 029)
Show SMILES Fc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H17ClF4N4O3/c24-17-5-3-13(9-16(17)23(26,27)28)30-22(34)31-19-6-4-14(10-18(19)25)35-15-7-8-29-20(11-15)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34)
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n/an/a 3.90n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235431
PNG
(US9359338, Exe. 041)
Show SMILES CC1CN(C(=O)O1)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C27H23F4N5O5/c1-14-13-36(26(39)40-14)19-9-16(27(29,30)31)8-18(10-19)34-25(38)33-17-4-5-22(21(28)11-17)41-20-6-7-32-23(12-20)35-24(37)15-2-3-15/h4-12,14-15H,2-3,13H2,1H3,(H,32,35,37)(H2,33,34,38)
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n/an/a 4.20n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235405
PNG
(US9359338, Exe. 015)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3cc(NC(=O)C4CC4)ncn3)nc2)ccc1Cl
Show InChI InChI=1S/C21H16ClF3N6O3/c22-15-5-3-12(7-14(15)21(23,24)25)29-20(33)30-13-4-6-17(26-9-13)34-18-8-16(27-10-28-18)31-19(32)11-1-2-11/h3-11H,1-2H2,(H2,29,30,33)(H,27,28,31,32)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235412
PNG
(US9359338, Exe. 022 | US9359338, Exe. 027)
Show SMILES Fc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C23H17ClF4N4O3/c24-17-5-3-13(9-16(17)23(26,27)28)30-22(34)31-14-4-6-19(18(25)10-14)35-15-7-8-29-20(11-15)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34)
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n/an/a 4.30n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235541
PNG
(US9359338, Exe. 151)
Show SMILES FC1(F)CCOc2ccc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3)cc12
Show InChI InChI=1S/C25H22F2N4O4/c26-25(27)10-12-34-21-8-5-17(13-20(21)25)30-24(33)29-16-3-6-18(7-4-16)35-19-9-11-28-22(14-19)31-23(32)15-1-2-15/h3-9,11,13-15H,1-2,10,12H2,(H,28,31,32)(H2,29,30,33)
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n/an/a 4.5n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM235454
PNG
(US9359338, Exe. 064)
Show SMILES CN1CCN(Cc2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C29H31F3N6O3/c1-37-10-12-38(13-11-37)18-19-14-21(29(30,31)32)16-23(15-19)35-28(40)34-22-4-6-24(7-5-22)41-25-8-9-33-26(17-25)36-27(39)20-2-3-20/h4-9,14-17,20H,2-3,10-13,18H2,1H3,(H,33,36,39)(H2,34,35,40)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use ADP-GLO™ assay kit from Promega to evaluate the inhibitory activity of compounds at B-Raf. [Instrument]: PerKinElmer...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235520
PNG
(US9359338, Exe. 130)
Show SMILES CS(=O)(=O)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)nc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N5O5S/c1-37(34,35)18-9-14(23(24,25)26)8-16(10-18)30-22(33)29-15-4-5-20(28-12-15)36-17-6-7-27-19(11-17)31-21(32)13-2-3-13/h4-13H,2-3H2,1H3,(H,27,31,32)(H2,29,30,33)
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n/an/a 4.60n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM235571
PNG
(US9359338, Exe. 181)
Show SMILES CC(F)(F)c1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c1
Show InChI InChI=1S/C24H20F4N4O3/c1-24(27,28)14-4-6-17(25)19(10-14)31-23(34)30-15-5-7-20(18(26)11-15)35-16-8-9-29-21(12-16)32-22(33)13-2-3-13/h4-13H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use ADP-GLO™ assay kit from Promega to evaluate the inhibitory activity of compounds at B-Raf. [Instrument]: PerKinElmer...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235565
PNG
(US9359338, Exe. 175)
Show SMILES Fc1cc(NC(=O)Nc2cccc(OC(F)(F)F)c2)ccc1Oc1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C23H18F4N4O4/c24-18-11-15(30-22(33)29-14-2-1-3-17(10-14)35-23(25,26)27)6-7-19(18)34-16-8-9-28-20(12-16)31-21(32)13-4-5-13/h1-3,6-13H,4-5H2,(H,28,31,32)(H2,29,30,33)
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n/an/a 4.90n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235576
PNG
(US9359338, Exe. 186)
Show SMILES Fc1cc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)-c2cccnc2)ccc1Oc1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C28H21F4N5O3/c29-23-13-20(5-6-24(23)40-22-7-9-34-25(14-22)37-26(38)16-3-4-16)35-27(39)36-21-11-18(17-2-1-8-33-15-17)10-19(12-21)28(30,31)32/h1-2,5-16H,3-4H2,(H,34,37,38)(H2,35,36,39)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM235414
PNG
(US9359338, Exe. 024)
Show SMILES Fc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cc(Oc2ccnc(NC(=O)C3CC3)c2)c1
Show InChI InChI=1S/C23H17ClF4N4O3/c24-19-4-3-14(10-18(19)23(26,27)28)30-22(34)31-15-7-13(25)8-17(9-15)35-16-5-6-29-20(11-16)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use ADP-GLO™ assay kit from Promega to evaluate the inhibitory activity of compounds at B-Raf. [Instrument]: PerKinElmer...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM235535
PNG
(US9359338, Exe. 145)
Show SMILES CS(=O)(=O)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C24H21F3N4O5S/c1-37(34,35)20-11-15(24(25,26)27)10-17(12-20)30-23(33)29-16-4-6-18(7-5-16)36-19-8-9-28-21(13-19)31-22(32)14-2-3-14/h4-14H,2-3H2,1H3,(H,28,31,32)(H2,29,30,33)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use ADP-GLO™ assay kit from Promega to evaluate the inhibitory activity of compounds at B-Raf. [Instrument]: PerKinElmer...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235441
PNG
(US9359338, Exe. 051)
Show SMILES OC1CCN(CC1)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H27F4N5O4/c29-23-14-18(3-4-24(23)41-22-5-8-33-25(15-22)36-26(39)16-1-2-16)34-27(40)35-19-11-17(28(30,31)32)12-20(13-19)37-9-6-21(38)7-10-37/h3-5,8,11-16,21,38H,1-2,6-7,9-10H2,(H,33,36,39)(H2,34,35,40)
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n/an/a 5.20n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM235428
PNG
(US9359338, Exe. 038)
Show SMILES CN1CCC(C1)Oc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H27F4N5O4/c1-37-9-7-21(15-37)40-22-11-17(28(30,31)32)10-19(12-22)35-27(39)34-18-4-5-24(23(29)13-18)41-20-6-8-33-25(14-20)36-26(38)16-2-3-16/h4-6,8,10-14,16,21H,2-3,7,9,15H2,1H3,(H,33,36,38)(H2,34,35,39)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use ADP-GLO™ assay kit from Promega to evaluate the inhibitory activity of compounds at B-Raf. [Instrument]: PerKinElmer...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235568
PNG
(US9359338, Exe. 178)
Show SMILES Fc1cc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)ccc1Oc1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C23H18F4N4O4/c24-18-11-15(30-22(33)29-14-3-6-16(7-4-14)35-23(25,26)27)5-8-19(18)34-17-9-10-28-20(12-17)31-21(32)13-1-2-13/h3-13H,1-2H2,(H,28,31,32)(H2,29,30,33)
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n/an/a 5.30n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235392
PNG
(US9359338, Exe. 002)
Show SMILES Fc1ccc(Oc2cc(NC(=O)C3CC3)ncn2)cc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C22H16ClF4N5O3/c23-15-5-3-12(7-14(15)22(25,26)27)30-21(34)31-17-8-13(4-6-16(17)24)35-19-9-18(28-10-29-19)32-20(33)11-1-2-11/h3-11H,1-2H2,(H2,30,31,34)(H,28,29,32,33)
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n/an/a 5.40n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235564
PNG
(US9359338, Exe. 174)
Show SMILES Fc1cc(NC(=O)Nc2cc(cc(n2)N2CCOCC2)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C26H24F4N6O4/c27-19-13-17(3-4-20(19)40-18-5-6-31-21(14-18)34-24(37)15-1-2-15)32-25(38)35-22-11-16(26(28,29)30)12-23(33-22)36-7-9-39-10-8-36/h3-6,11-15H,1-2,7-10H2,(H,31,34,37)(H2,32,33,35,38)
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n/an/a 5.40n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM235533
PNG
(US9359338, Exe. 143)
Show SMILES CN1CCC(CC1)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H30F3N5O3/c1-37-12-9-18(10-13-37)20-14-21(29(30,31)32)16-23(15-20)35-28(39)34-22-4-6-24(7-5-22)40-25-8-11-33-26(17-25)36-27(38)19-2-3-19/h4-8,11,14-19H,2-3,9-10,12-13H2,1H3,(H,33,36,38)(H2,34,35,39)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use ADP-GLO™ assay kit from Promega to evaluate the inhibitory activity of compounds at B-Raf. [Instrument]: PerKinElmer...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235555
PNG
(US9359338, Exe. 165)
Show SMILES CS(=O)(=O)Nc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C24H21F4N5O5S/c1-39(36,37)33-17-9-14(24(26,27)28)8-16(10-17)31-23(35)30-15-4-5-20(19(25)11-15)38-18-6-7-29-21(12-18)32-22(34)13-2-3-13/h4-13,33H,2-3H2,1H3,(H,29,32,34)(H2,30,31,35)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235453
PNG
(US9359338, Exe. 063)
Show SMILES Fc1cc(NC(=O)Nc2ccc(Cl)c(OC(F)(F)F)c2)ccc1Oc1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C23H17ClF4N4O4/c24-16-5-3-14(10-19(16)36-23(26,27)28)31-22(34)30-13-4-6-18(17(25)9-13)35-15-7-8-29-20(11-15)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235602
PNG
(US9359338, Exe. 212)
Show SMILES Fc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cc(cc(c1)C(F)(F)F)N1CC(F)(F)C1
Show InChI InChI=1S/C26H21F6N5O3/c27-20-10-18(40-19-5-6-33-22(11-19)36-23(38)14-1-2-14)3-4-21(20)35-24(39)34-16-7-15(26(30,31)32)8-17(9-16)37-12-25(28,29)13-37/h3-11,14H,1-2,12-13H2,(H,33,36,38)(H2,34,35,39)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235560
PNG
(US9359338, Exe. 170)
Show SMILES Fc1cc(NC(=O)Nc2cc(ncn2)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C21H16F4N6O3/c22-14-7-12(29-20(33)31-18-9-16(21(23,24)25)27-10-28-18)3-4-15(14)34-13-5-6-26-17(8-13)30-19(32)11-1-2-11/h3-11H,1-2H2,(H,26,30,32)(H2,27,28,29,31,33)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235423
PNG
(US9359338, Exe. 033)
Show SMILES CC(F)(F)c1cncc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)c1
Show InChI InChI=1S/C23H20F3N5O3/c1-23(25,26)14-8-15(12-27-11-14)29-22(33)30-19-5-4-16(9-18(19)24)34-17-6-7-28-20(10-17)31-21(32)13-2-3-13/h4-13H,2-3H2,1H3,(H,28,31,32)(H2,29,30,33)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235397
PNG
(US9359338, Exe. 007)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3cc(NC(=O)C4CC4)ncn3)cc2)ccc1Cl
Show InChI InChI=1S/C22H17ClF3N5O3/c23-17-8-5-14(9-16(17)22(24,25)26)30-21(33)29-13-3-6-15(7-4-13)34-19-10-18(27-11-28-19)31-20(32)12-1-2-12/h3-12H,1-2H2,(H2,29,30,33)(H,27,28,31,32)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235587
PNG
(US9359338, Exe. 197)
Show SMILES Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cc(F)cc(c1)C(C)(F)F
Show InChI InChI=1S/C25H23F3N4O3/c1-14-9-19(35-20-7-8-29-22(13-20)32-23(33)15-3-4-15)5-6-21(14)31-24(34)30-18-11-16(25(2,27)28)10-17(26)12-18/h5-13,15H,3-4H2,1-2H3,(H,29,32,33)(H2,30,31,34)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235398
PNG
(US9359338, Exe. 008)
Show SMILES Fc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)ccc1Oc1cc(NC(=O)C2CC2)ncn1
Show InChI InChI=1S/C22H16ClF4N5O3/c23-15-5-3-12(7-14(15)22(25,26)27)30-21(34)31-13-4-6-17(16(24)8-13)35-19-9-18(28-10-29-19)32-20(33)11-1-2-11/h3-11H,1-2H2,(H2,30,31,34)(H,28,29,32,33)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235566
PNG
(US9359338, Exe. 176)
Show SMILES Fc1ccc(OC(F)(F)F)cc1NC(=O)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1
Show InChI InChI=1S/C23H17F5N4O4/c24-16-5-4-15(36-23(26,27)28)10-18(16)31-22(34)30-13-3-6-19(17(25)9-13)35-14-7-8-29-20(11-14)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235410
PNG
(US9359338, Exe. 020)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)nc2)ccc1Cl
Show InChI InChI=1S/C22H17ClF3N5O3/c23-17-5-3-13(9-16(17)22(24,25)26)29-21(33)30-14-4-6-19(28-11-14)34-15-7-8-27-18(10-15)31-20(32)12-1-2-12/h3-12H,1-2H2,(H,27,31,32)(H2,29,30,33)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235525
PNG
(US9359338, Exe. 135)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cn2)c1
Show InChI InChI=1S/C22H18F3N5O3/c23-22(24,25)14-2-1-3-15(10-14)28-21(32)30-18-7-6-17(12-27-18)33-16-8-9-26-19(11-16)29-20(31)13-4-5-13/h1-3,6-13H,4-5H2,(H,26,29,31)(H2,27,28,30,32)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235547
PNG
(US9359338, Exe. 157)
Show SMILES Fc1cc(NC(=O)Nc2cc(ccc2Cl)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C23H17ClF4N4O3/c24-16-5-3-13(23(26,27)28)9-18(16)31-22(34)30-14-4-6-19(17(25)10-14)35-15-7-8-29-20(11-15)32-21(33)12-1-2-12/h3-12H,1-2H2,(H,29,32,33)(H2,30,31,34)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235585
PNG
(US9359338, Exe. 195)
Show SMILES Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C24H20F4N4O4/c1-13-10-15(35-16-8-9-29-21(12-16)32-22(33)14-2-3-14)5-7-19(13)30-23(34)31-20-11-17(4-6-18(20)25)36-24(26,27)28/h4-12,14H,2-3H2,1H3,(H,29,32,33)(H2,30,31,34)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235521
PNG
(US9359338, Exe. 131)
Show SMILES CN1CCC(CC1)Nc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)nc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H30F3N7O3/c1-38-10-7-19(8-11-38)34-21-12-18(28(29,30)31)13-22(14-21)36-27(40)35-20-4-5-25(33-16-20)41-23-6-9-32-24(15-23)37-26(39)17-2-3-17/h4-6,9,12-17,19,34H,2-3,7-8,10-11H2,1H3,(H,32,37,39)(H2,35,36,40)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM235518
PNG
(US9359338, Exe. 128)
Show SMILES Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ncc1NC(=O)Nc1cc(ccc1F)C(C)(F)F
Show InChI InChI=1S/C24H22F3N5O3/c1-13-9-21(35-16-7-8-28-20(11-16)32-22(33)14-3-4-14)29-12-19(13)31-23(34)30-18-10-15(24(2,26)27)5-6-17(18)25/h5-12,14H,3-4H2,1-2H3,(H,28,32,33)(H2,30,31,34)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use ADP-GLO™ assay kit from Promega to evaluate the inhibitory activity of compounds at B-Raf. [Instrument]: PerKinElmer...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235437
PNG
(US9359338, Exe. 047)
Show SMILES CC1CN(CC(C)O1)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H29F4N5O4/c1-16-14-38(15-17(2)41-16)22-10-19(29(31,32)33)9-21(11-22)36-28(40)35-20-5-6-25(24(30)12-20)42-23-7-8-34-26(13-23)37-27(39)18-3-4-18/h5-13,16-18H,3-4,14-15H2,1-2H3,(H,34,37,39)(H2,35,36,40)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235538
PNG
(US9359338, Exe. 148)
Show SMILES CC(F)(F)c1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)c1
Show InChI InChI=1S/C24H21F3N4O3/c1-24(26,27)15-4-9-19(25)20(12-15)30-23(33)29-16-5-7-17(8-6-16)34-18-10-11-28-21(13-18)31-22(32)14-2-3-14/h4-14H,2-3H2,1H3,(H,28,31,32)(H2,29,30,33)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM235451
PNG
(US9359338, Exe. 061)
Show SMILES Fc1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)ccc1Oc1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C23H18F4N4O3/c24-18-11-16(30-22(33)29-15-3-1-2-14(10-15)23(25,26)27)6-7-19(18)34-17-8-9-28-20(12-17)31-21(32)13-4-5-13/h1-3,6-13H,4-5H2,(H,28,31,32)(H2,29,30,33)
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CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use ADP-GLO™ assay kit from Promega to evaluate the inhibitory activity of compounds at B-Raf. [Instrument]: PerKinElmer...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM235601
PNG
(US9359338, Exe. 211)
Show SMILES Fc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H18F4N4O3/c24-18-11-16(34-17-8-9-28-20(12-17)31-21(32)13-4-5-13)6-7-19(18)30-22(33)29-15-3-1-2-14(10-15)23(25,26)27/h1-3,6-13H,4-5H2,(H,28,31,32)(H2,29,30,33)
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n/an/a 6.40n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use ADP-GLO™ assay kit from Promega to evaluate the inhibitory activity of compounds at B-Raf. [Instrument]: PerKinElmer...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235455
PNG
(US9359338, Exe. 065)
Show SMILES CC(F)(F)c1cncc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)c1
Show InChI InChI=1S/C23H21F2N5O3/c1-23(24,25)15-10-17(13-26-12-15)29-22(32)28-16-4-6-18(7-5-16)33-19-8-9-27-20(11-19)30-21(31)14-2-3-14/h4-14H,2-3H2,1H3,(H,27,30,31)(H2,28,29,32)
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n/an/a 6.5n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM235555
PNG
(US9359338, Exe. 165)
Show SMILES CS(=O)(=O)Nc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C24H21F4N5O5S/c1-39(36,37)33-17-9-14(24(26,27)28)8-16(10-17)31-23(35)30-15-4-5-20(19(25)11-15)38-18-6-7-29-21(12-18)32-22(34)13-2-3-13/h4-13,33H,2-3H2,1H3,(H,29,32,34)(H2,30,31,35)
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n/an/a 6.60n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use ADP-GLO™ assay kit from Promega to evaluate the inhibitory activity of compounds at B-Raf. [Instrument]: PerKinElmer...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235526
PNG
(US9359338, Exe. 136)
Show SMILES CS(=O)(=O)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cn2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N5O5S/c1-37(34,35)18-9-14(23(24,25)26)8-15(10-18)29-22(33)31-19-5-4-17(12-28-19)36-16-6-7-27-20(11-16)30-21(32)13-2-3-13/h4-13H,2-3H2,1H3,(H,27,30,32)(H2,28,29,31,33)
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n/an/a 6.60n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235611
PNG
(US9359338, Exe. 221)
Show SMILES Fc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C23H17ClFN5O3/c24-18-9-15(4-3-14(18)12-26)28-23(32)29-20-6-5-16(10-19(20)25)33-17-7-8-27-21(11-17)30-22(31)13-1-2-13/h3-11,13H,1-2H2,(H,27,30,31)(H2,28,29,32)
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n/an/a 6.70n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235552
PNG
(US9359338, Exe. 162)
Show SMILES CC1CN(CCO1)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H27F4N5O4/c1-16-15-37(8-9-40-16)21-11-18(28(30,31)32)10-20(12-21)35-27(39)34-19-4-5-24(23(29)13-19)41-22-6-7-33-25(14-22)36-26(38)17-2-3-17/h4-7,10-14,16-17H,2-3,8-9,15H2,1H3,(H,33,36,38)(H2,34,35,39)
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n/an/a 6.80n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM235583
PNG
(US9359338, Exe. 193)
Show SMILES Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H21F3N4O3/c1-14-11-18(34-19-9-10-28-21(13-19)31-22(32)15-5-6-15)7-8-20(14)30-23(33)29-17-4-2-3-16(12-17)24(25,26)27/h2-4,7-13,15H,5-6H2,1H3,(H,28,31,32)(H2,29,30,33)
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n/an/a 6.80n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use ADP-GLO™ assay kit from Promega to evaluate the inhibitory activity of compounds at B-Raf. [Instrument]: PerKinElmer...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235472
PNG
(US9359338, Exe. 082)
Show SMILES Cc1cc(Oc2cc(NC(=O)C3CC3)ncn2)ccc1NC(=O)Nc1ccc(Cl)c(OC(F)(F)F)c1
Show InChI InChI=1S/C23H19ClF3N5O4/c1-12-8-15(35-20-10-19(28-11-29-20)32-21(33)13-2-3-13)5-7-17(12)31-22(34)30-14-4-6-16(24)18(9-14)36-23(25,26)27/h4-11,13H,2-3H2,1H3,(H2,30,31,34)(H,28,29,32,33)
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n/an/a 6.80n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235577
PNG
(US9359338, Exe. 187)
Show SMILES CC(C)Nc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C26H25F4N5O3/c1-14(2)32-18-9-16(26(28,29)30)10-19(11-18)34-25(37)33-17-5-6-22(21(27)12-17)38-20-7-8-31-23(13-20)35-24(36)15-3-4-15/h5-15,32H,3-4H2,1-2H3,(H,31,35,36)(H2,33,34,37)
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n/an/a 6.80n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (VEGFR2)


(Homo sapiens (Human))
BDBM235613
PNG
(US9359338, Exe. 223)
Show SMILES Cc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1NC(=O)Nc1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H20F4N4O3/c1-13-2-6-16(35-17-8-9-29-21(12-17)32-22(33)14-3-4-14)11-20(13)31-23(34)30-15-5-7-19(25)18(10-15)24(26,27)28/h2,5-12,14H,3-4H2,1H3,(H,29,32,33)(H2,30,31,34)
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n/an/a 6.90n/an/an/an/an/an/a



CROWN BIOSCIENCE INC. (Taiwan)

US Patent


Assay Description
[Experimental method]: Use Lance@Ultra Ulight™-TK assay kit from PerKinElmer to evaluate the inhibitory activity of compounds at KDR kinase. [I...


Citation and Details
More data for this
Ligand-Target Pair
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