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Patent code US9359348

Compile Data Set for Download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235175
PNG
(US9359348, 9)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1nc2ccccn2c1C
Show InChI InChI=1S/C20H21N7/c1-11-20(24-18-7-5-6-8-26(11)18)16-9-15(16)17-10-19(23-12(2)22-17)27-14(4)21-13(3)25-27/h5-8,10,15-16H,9H2,1-4H3/t15-,16-/m1/s1
PDB

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US Patent
2.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235176
PNG
(US9359348, 10)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1nc2ccccn2c1C=C
Show InChI InChI=1S/C21H21N7/c1-5-18-21(25-19-8-6-7-9-27(18)19)16-10-15(16)17-11-20(24-12(2)23-17)28-14(4)22-13(3)26-28/h5-9,11,15-16H,1,10H2,2-4H3/t15-,16-/m1/s1
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US Patent
3.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235167
PNG
(US9359348, 1)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)C1C[C@H]1c1cn2ccccc2n1
Show InChI InChI=1S/C19H19N7/c1-11-21-16(9-19(22-11)26-13(3)20-12(2)24-26)14-8-15(14)17-10-25-7-5-4-6-18(25)23-17/h4-7,9-10,14-15H,8H2,1-3H3/t14?,15-/m1/s1
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US Patent
5.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235168
PNG
(US9359348, 2)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1cn2c(C)cccc2n1
Show InChI InChI=1S/C20H21N7/c1-11-6-5-7-19-24-18(10-26(11)19)16-8-15(16)17-9-20(23-12(2)22-17)27-14(4)21-13(3)25-27/h5-7,9-10,15-16H,8H2,1-4H3/t15-,16-/m1/s1
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US Patent
8.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235174
PNG
(US9359348, 8)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1nc2ccccn2c1I
Show InChI InChI=1S/C19H18IN7/c1-10-22-15(9-17(23-10)27-12(3)21-11(2)25-27)13-8-14(13)18-19(20)26-7-5-4-6-16(26)24-18/h4-7,9,13-14H,8H2,1-3H3/t13-,14-/m1/s1
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9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235173
PNG
(US9359348, 7)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1cn2ccc(F)cc2n1
Show InChI InChI=1S/C19H18FN7/c1-10-22-16(8-19(23-10)27-12(3)21-11(2)25-27)14-7-15(14)17-9-26-5-4-13(20)6-18(26)24-17/h4-6,8-9,14-15H,7H2,1-3H3/t14-,15-/m1/s1
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13n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235169
PNG
(US9359348, 3)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1cn2cc(C)ccc2n1
Show InChI InChI=1S/C20H21N7/c1-11-5-6-19-24-18(10-26(19)9-11)16-7-15(16)17-8-20(23-12(2)22-17)27-14(4)21-13(3)25-27/h5-6,8-10,15-16H,7H2,1-4H3/t15-,16-/m1/s1
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24n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235170
PNG
(US9359348, 4)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1cn2ccc(C)cc2n1
Show InChI InChI=1S/C20H21N7/c1-11-5-6-26-10-18(24-19(26)7-11)16-8-15(16)17-9-20(23-12(2)22-17)27-14(4)21-13(3)25-27/h5-7,9-10,15-16H,8H2,1-4H3/t15-,16-/m1/s1
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44n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235177
PNG
(US9359348, 11)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1nc2ccccn2c1C#N
Show InChI InChI=1S/C20H18N8/c1-11-23-16(9-19(24-11)28-13(3)22-12(2)26-28)14-8-15(14)20-17(10-21)27-7-5-4-6-18(27)25-20/h4-7,9,14-15H,8H2,1-3H3/t14-,15-/m1/s1
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>75n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235172
PNG
(US9359348, 6)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1cn2cccc(F)c2n1
Show InChI InChI=1S/C19H18FN7/c1-10-22-16(8-18(23-10)27-12(3)21-11(2)25-27)13-7-14(13)17-9-26-6-4-5-15(20)19(26)24-17/h4-6,8-9,13-14H,7H2,1-3H3/t13-,14-/m1/s1
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US Patent
>75n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235171
PNG
(US9359348, 5)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1cn2cccc(C)c2n1
Show InChI InChI=1S/C20H21N7/c1-11-6-5-7-26-10-18(24-20(11)26)16-8-15(16)17-9-19(23-12(2)22-17)27-14(4)21-13(3)25-27/h5-7,9-10,15-16H,8H2,1-4H3/t15-,16-/m1/s1
PDB

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US Patent
>75n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%