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Patent code US9359371

Compile Data Set for Download or QSAR
Found 77 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235762
PNG
(US9359371, 46)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCN2CCN(C)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C26H36ClN7O2/c1-32-11-13-33(14-12-32)10-8-28-24(35)20-17-30-25(34-9-7-26(18-34)5-6-26)31-23(20)29-16-19-3-4-22(36-2)21(27)15-19/h3-4,15,17H,5-14,16,18H2,1-2H3,(H,28,35)(H,29,30,31)
PDB

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US Patent
n/an/a 0.310n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235742
PNG
(US9359371, 11)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H30ClN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18-
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US Patent
n/an/a 0.410n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235755
PNG
(US9359371, 38)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C25H32ClN5O3/c1-34-21-7-2-16(12-20(21)26)13-27-22-19(23(33)29-17-3-5-18(32)6-4-17)14-28-24(30-22)31-11-10-25(15-31)8-9-25/h2,7,12,14,17-18,32H,3-6,8-11,13,15H2,1H3,(H,29,33)(H,27,28,30)/t17-,18-
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n/an/a 0.800n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235735
PNG
(US9359371, 3)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccc2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C25H26ClN5O2/c1-33-22-8-7-17(9-21(22)26)12-27-23-20(24(32)28-11-16-5-3-2-4-6-16)13-29-25(30-23)31-14-18-10-19(18)15-31/h2-9,13,18-19H,10-12,14-15H2,1H3,(H,28,32)(H,27,29,30)
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n/an/a 0.910n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235742
PNG
(US9359371, 11)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H30ClN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18-
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US Patent
n/an/a 1.31n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235734
PNG
(US9359371, 2)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccn2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H25ClN6O2/c1-33-21-6-5-15(8-20(21)25)10-27-22-19(23(32)28-11-18-4-2-3-7-26-18)12-29-24(30-22)31-13-16-9-17(16)14-31/h2-8,12,16-17H,9-11,13-14H2,1H3,(H,28,32)(H,27,29,30)
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n/an/a 2.12n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235742
PNG
(US9359371, 11)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H30ClN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18-
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US Patent
n/an/a 4.02n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235738
PNG
(US9359371, 6)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCN2CCOCC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H31ClN6O3/c1-33-21-3-2-16(10-20(21)25)12-27-22-19(23(32)26-4-5-30-6-8-34-9-7-30)13-28-24(29-22)31-14-17-11-18(17)15-31/h2-3,10,13,17-18H,4-9,11-12,14-15H2,1H3,(H,26,32)(H,27,28,29)
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n/an/a 4.25n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235750
PNG
(US9359371, 32)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccc2)N2CC3CC3C2CO)cc1Cl
Show InChI InChI=1S/C26H28ClN5O3/c1-35-23-8-7-17(9-21(23)27)12-28-24-20(25(34)29-11-16-5-3-2-4-6-16)13-30-26(31-24)32-14-18-10-19(18)22(32)15-33/h2-9,13,18-19,22,33H,10-12,14-15H2,1H3,(H,29,34)(H,28,30,31)
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n/an/a 4.63n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235736
PNG
(US9359371, 4)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2cnc(C)cn2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H26ClN7O2/c1-14-7-27-18(9-26-14)10-29-23(33)19-11-30-24(32-12-16-6-17(16)13-32)31-22(19)28-8-15-3-4-21(34-2)20(25)5-15/h3-5,7,9,11,16-17H,6,8,10,12-13H2,1-2H3,(H,29,33)(H,28,30,31)
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US Patent
n/an/a 4.63n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235733
PNG
(US9359371, 1)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C23H24ClN7O2/c1-33-19-4-3-14(7-18(19)24)9-27-21-17(22(32)28-11-20-25-5-2-6-26-20)10-29-23(30-21)31-12-15-8-16(15)13-31/h2-7,10,15-16H,8-9,11-13H2,1H3,(H,28,32)(H,27,29,30)
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n/an/a 6.04n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235733
PNG
(US9359371, 1)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C23H24ClN7O2/c1-33-19-4-3-14(7-18(19)24)9-27-21-17(22(32)28-11-20-25-5-2-6-26-20)10-29-23(30-21)31-12-15-8-16(15)13-31/h2-7,10,15-16H,8-9,11-13H2,1H3,(H,28,32)(H,27,29,30)
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n/an/a 6.04n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
PDB

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n/an/a 6.99n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235765
PNG
(US9359371, 50)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1C
Show InChI InChI=1S/C25H33N5O3/c1-15-9-16(3-8-22(15)33-2)11-26-23-21(24(32)28-19-4-6-20(31)7-5-19)12-27-25(29-23)30-13-17-10-18(17)14-30/h3,8-9,12,17-20,31H,4-7,10-11,13-14H2,1-2H3,(H,28,32)(H,26,27,29)/t17?,18?,19-,20-
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n/an/a 7.72n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235764
PNG
(US9359371, 48)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1F
Show InChI InChI=1S/C24H30FN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18-
PDB

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n/an/a 7.99n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
PDB

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n/an/a 8.56n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235735
PNG
(US9359371, 3)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccc2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C25H26ClN5O2/c1-33-22-8-7-17(9-21(22)26)12-27-23-20(24(32)28-11-16-5-3-2-4-6-16)13-29-25(30-23)31-14-18-10-19(18)15-31/h2-9,13,18-19H,10-12,14-15H2,1H3,(H,28,32)(H,27,29,30)
UniProtKB/SwissProt

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n/an/a 8.89n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
PDB

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n/an/a 9.29n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235748
PNG
(US9359371, 27)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CC3CC3C2CO)cc1Cl
Show InChI InChI=1S/C24H26ClN7O3/c1-35-20-4-3-14(7-18(20)25)9-28-22-17(23(34)29-11-21-26-5-2-6-27-21)10-30-24(31-22)32-12-15-8-16(15)19(32)13-33/h2-7,10,15-16,19,33H,8-9,11-13H2,1H3,(H,29,34)(H,28,30,31)
PDB

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n/an/a 10.4n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
PDB

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US Patent
n/an/a 10.8n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
PDB

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US Patent
n/an/a 10.8n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235757
PNG
(US9359371, 40)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccn2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C25H27ClN6O2/c1-34-21-6-5-17(12-20(21)26)13-28-22-19(23(33)29-14-18-4-2-3-10-27-18)15-30-24(31-22)32-11-9-25(16-32)7-8-25/h2-6,10,12,15H,7-9,11,13-14,16H2,1H3,(H,29,33)(H,28,30,31)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235735
PNG
(US9359371, 3)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccc2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C25H26ClN5O2/c1-33-22-8-7-17(9-21(22)26)12-27-23-20(24(32)28-11-16-5-3-2-4-6-16)13-29-25(30-23)31-14-18-10-19(18)15-31/h2-9,13,18-19H,10-12,14-15H2,1H3,(H,28,32)(H,27,29,30)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235740
PNG
(US9359371, 8)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CCCCNC2=O)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H29ClN6O3/c1-34-20-6-5-14(8-18(20)25)10-27-21-17(22(32)29-19-4-2-3-7-26-23(19)33)11-28-24(30-21)31-12-15-9-16(15)13-31/h5-6,8,11,15-16,19H,2-4,7,9-10,12-13H2,1H3,(H,26,33)(H,29,32)(H,27,28,30)/t15?,16?,19-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235762
PNG
(US9359371, 46)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCN2CCN(C)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C26H36ClN7O2/c1-32-11-13-33(14-12-32)10-8-28-24(35)20-17-30-25(34-9-7-26(18-34)5-6-26)31-23(20)29-16-19-3-4-22(36-2)21(27)15-19/h3-4,15,17H,5-14,16,18H2,1-2H3,(H,28,35)(H,29,30,31)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235760
PNG
(US9359371, 43)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@@H]2CC[C@H](O)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C25H32ClN5O3/c1-34-21-7-2-16(12-20(21)26)13-27-22-19(23(33)29-17-3-5-18(32)6-4-17)14-28-24(30-22)31-11-10-25(15-31)8-9-25/h2,7,12,14,17-18,32H,3-6,8-11,13,15H2,1H3,(H,29,33)(H,27,28,30)/t17-,18+
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235746
PNG
(US9359371, 21)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccc2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C26H28ClN5O2/c1-34-22-8-7-19(13-21(22)27)15-28-23-20(24(33)29-14-18-5-3-2-4-6-18)16-30-25(31-23)32-12-11-26(17-32)9-10-26/h2-8,13,16H,9-12,14-15,17H2,1H3,(H,29,33)(H,28,30,31)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235737
PNG
(US9359371, 5)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccc(F)cc2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C25H25ClFN5O2/c1-34-22-7-4-16(8-21(22)26)11-28-23-20(24(33)29-10-15-2-5-19(27)6-3-15)12-30-25(31-23)32-13-17-9-18(17)14-32/h2-8,12,17-18H,9-11,13-14H2,1H3,(H,29,33)(H,28,30,31)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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n/an/a 20.9n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235756
PNG
(US9359371, 39)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCN2CCOCC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C25H33ClN6O3/c1-34-21-3-2-18(14-20(21)26)15-28-22-19(23(33)27-7-9-31-10-12-35-13-11-31)16-29-24(30-22)32-8-6-25(17-32)4-5-25/h2-3,14,16H,4-13,15,17H2,1H3,(H,27,33)(H,28,29,30)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235749
PNG
(US9359371, 28)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccc2)N2CCC3(CCC3)C2)cc1Cl
Show InChI InChI=1S/C27H30ClN5O2/c1-35-23-9-8-20(14-22(23)28)16-29-24-21(25(34)30-15-19-6-3-2-4-7-19)17-31-26(32-24)33-13-12-27(18-33)10-5-11-27/h2-4,6-9,14,17H,5,10-13,15-16,18H2,1H3,(H,30,34)(H,29,31,32)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235758
PNG
(US9359371, 41)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C24H26ClN7O2/c1-34-19-4-3-16(11-18(19)25)12-28-21-17(22(33)29-14-20-26-8-2-9-27-20)13-30-23(31-21)32-10-7-24(15-32)5-6-24/h2-4,8-9,11,13H,5-7,10,12,14-15H2,1H3,(H,29,33)(H,28,30,31)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235741
PNG
(US9359371, 9)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NC2CCCCCC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C25H32ClN5O2/c1-33-22-9-8-16(10-21(22)26)12-27-23-20(24(32)29-19-6-4-2-3-5-7-19)13-28-25(30-23)31-14-17-11-18(17)15-31/h8-10,13,17-19H,2-7,11-12,14-15H2,1H3,(H,29,32)(H,27,28,30)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235766
PNG
(US9359371, Avanafil)
Show SMILES COc1ccc(CN=c2[nH]c(ncc2C(O)=NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235744
PNG
(US9359371, 15)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CCC3(CC3)CC2)cc1Cl
Show InChI InChI=1S/C25H28ClN7O2/c1-35-20-4-3-17(13-19(20)26)14-29-22-18(23(34)30-16-21-27-9-2-10-28-21)15-31-24(32-22)33-11-7-25(5-6-25)8-12-33/h2-4,9-10,13,15H,5-8,11-12,14,16H2,1H3,(H,30,34)(H,29,31,32)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235754
PNG
(US9359371, 37)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccn2)N2CC3CC3C2CO)cc1Cl
Show InChI InChI=1S/C25H27ClN6O3/c1-35-22-6-5-15(8-20(22)26)10-28-23-19(24(34)29-11-17-4-2-3-7-27-17)12-30-25(31-23)32-13-16-9-18(16)21(32)14-33/h2-8,12,16,18,21,33H,9-11,13-14H2,1H3,(H,29,34)(H,28,30,31)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235751
PNG
(US9359371, 34)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCN2CCOCC2)N2CC3CC3C2CO)cc1Cl
Show InChI InChI=1S/C25H33ClN6O4/c1-35-22-3-2-16(10-20(22)26)12-28-23-19(24(34)27-4-5-31-6-8-36-9-7-31)13-29-25(30-23)32-14-17-11-18(17)21(32)15-33/h2-3,10,13,17-18,21,33H,4-9,11-12,14-15H2,1H3,(H,27,34)(H,28,29,30)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235747
PNG
(US9359371, 25)
Show SMILES COc1ncc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C22H23ClN8O2/c1-33-21-17(23)5-13(8-28-21)7-26-19-16(20(32)27-10-18-24-3-2-4-25-18)9-29-22(30-19)31-11-14-6-15(14)12-31/h2-5,8-9,14-15H,6-7,10-12H2,1H3,(H,27,32)(H,26,29,30)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235752
PNG
(US9359371, 35)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2CO)cc1Cl
Show InChI InChI=1S/C25H32ClN5O4/c1-35-22-7-2-14(8-20(22)26)10-27-23-19(24(34)29-16-3-5-17(33)6-4-16)11-28-25(30-23)31-12-15-9-18(15)21(31)13-32/h2,7-8,11,15-18,21,32-33H,3-6,9-10,12-13H2,1H3,(H,29,34)(H,27,28,30)/t15?,16-,17-,18?,21?
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Homo sapiens (Human))
BDBM235753
PNG
(US9359371, 36)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CCC3(CC3)CC2)cc1Cl
Show InChI InChI=1S/C26H34ClN5O3/c1-35-22-7-2-17(14-21(22)27)15-28-23-20(24(34)30-18-3-5-19(33)6-4-18)16-29-25(31-23)32-12-10-26(8-9-26)11-13-32/h2,7,14,16,18-19,33H,3-6,8-13,15H2,1H3,(H,30,34)(H,28,29,31)/t18-,19-
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n/an/a 52.4n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235755
PNG
(US9359371, 38)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C25H32ClN5O3/c1-34-21-7-2-16(12-20(21)26)13-27-22-19(23(33)29-17-3-5-18(32)6-4-17)14-28-24(30-22)31-11-10-25(15-31)8-9-25/h2,7,12,14,17-18,32H,3-6,8-11,13,15H2,1H3,(H,29,33)(H,27,28,30)/t17-,18-
UniProtKB/SwissProt

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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235742
PNG
(US9359371, 11)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H30ClN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18-
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235762
PNG
(US9359371, 46)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCN2CCN(C)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C26H36ClN7O2/c1-32-11-13-33(14-12-32)10-8-28-24(35)20-17-30-25(34-9-7-26(18-34)5-6-26)31-23(20)29-16-19-3-4-22(36-2)21(27)15-19/h3-4,15,17H,5-14,16,18H2,1-2H3,(H,28,35)(H,29,30,31)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235765
PNG
(US9359371, 50)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1C
Show InChI InChI=1S/C25H33N5O3/c1-15-9-16(3-8-22(15)33-2)11-26-23-21(24(32)28-19-4-6-20(31)7-5-19)12-27-25(29-23)30-13-17-10-18(17)14-30/h3,8-9,12,17-20,31H,4-7,10-11,13-14H2,1-2H3,(H,28,32)(H,26,27,29)/t17?,18?,19-,20-
UniProtKB/SwissProt

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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235764
PNG
(US9359371, 48)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1F
Show InChI InChI=1S/C24H30FN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18-
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n/an/a 1.11E+3n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235740
PNG
(US9359371, 8)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CCCCNC2=O)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H29ClN6O3/c1-34-20-6-5-14(8-18(20)25)10-27-21-17(22(32)29-19-4-2-3-7-26-23(19)33)11-28-24(30-21)31-12-15-9-16(15)13-31/h5-6,8,11,15-16,19H,2-4,7,9-10,12-13H2,1H3,(H,26,33)(H,29,32)(H,27,28,30)/t15?,16?,19-/m0/s1
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235738
PNG
(US9359371, 6)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCN2CCOCC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H31ClN6O3/c1-33-21-3-2-16(10-20(21)25)12-27-22-19(23(32)26-4-5-30-6-8-34-9-7-30)13-28-24(29-22)31-14-17-11-18(17)15-31/h2-3,10,13,17-18H,4-9,11-12,14-15H2,1H3,(H,26,32)(H,27,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235739
PNG
(US9359371, 7)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCC2CCNCC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H31ClN6O2/c1-33-21-3-2-16(8-20(21)25)11-27-22-19(23(32)28-10-15-4-6-26-7-5-15)12-29-24(30-22)31-13-17-9-18(17)14-31/h2-3,8,12,15,17-18,26H,4-7,9-11,13-14H2,1H3,(H,28,32)(H,27,29,30)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235741
PNG
(US9359371, 9)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NC2CCCCCC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C25H32ClN5O2/c1-33-22-9-8-16(10-21(22)26)12-27-23-20(24(32)29-19-6-4-2-3-5-7-19)13-28-25(30-23)31-14-17-11-18(17)15-31/h8-10,13,17-19H,2-7,11-12,14-15H2,1H3,(H,29,32)(H,27,28,30)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235759
PNG
(US9359371, 42)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCN2CCNCC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C25H34ClN7O2/c1-35-21-3-2-18(14-20(21)26)15-29-22-19(23(34)28-9-13-32-11-7-27-8-12-32)16-30-24(31-22)33-10-6-25(17-33)4-5-25/h2-3,14,16,27H,4-13,15,17H2,1H3,(H,28,34)(H,29,30,31)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235763
PNG
(US9359371, 47)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCC2CCC(O)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C26H34ClN5O3/c1-35-22-7-4-18(12-21(22)27)14-28-23-20(24(34)29-13-17-2-5-19(33)6-3-17)15-30-25(31-23)32-11-10-26(16-32)8-9-26/h4,7,12,15,17,19,33H,2-3,5-6,8-11,13-14,16H2,1H3,(H,29,34)(H,28,30,31)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235733
PNG
(US9359371, 1)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C23H24ClN7O2/c1-33-19-4-3-14(7-18(19)24)9-27-21-17(22(32)28-11-20-25-5-2-6-26-20)10-29-23(30-21)31-12-15-8-16(15)13-31/h2-7,10,15-16H,8-9,11-13H2,1H3,(H,28,32)(H,27,29,30)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235734
PNG
(US9359371, 2)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccn2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H25ClN6O2/c1-33-21-6-5-15(8-20(21)25)10-27-22-19(23(32)28-11-18-4-2-3-7-26-18)12-29-24(30-22)31-13-16-9-17(16)14-31/h2-8,12,16-17H,9-11,13-14H2,1H3,(H,28,32)(H,27,29,30)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235736
PNG
(US9359371, 4)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2cnc(C)cn2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H26ClN7O2/c1-14-7-27-18(9-26-14)10-29-23(33)19-11-30-24(32-12-16-6-17(16)13-32)31-22(19)28-8-15-3-4-21(34-2)20(25)5-15/h3-5,7,9,11,16-17H,6,8,10,12-13H2,1-2H3,(H,29,33)(H,28,30,31)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235743
PNG
(US9359371, 14)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CCC3(CCC3)CC2)cc1Cl
Show InChI InChI=1S/C26H30ClN7O2/c1-36-21-5-4-18(14-20(21)27)15-30-23-19(24(35)31-17-22-28-10-3-11-29-22)16-32-25(33-23)34-12-8-26(9-13-34)6-2-7-26/h3-5,10-11,14,16H,2,6-9,12-13,15,17H2,1H3,(H,31,35)(H,30,32,33)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235762
PNG
(US9359371, 46)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCN2CCN(C)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C26H36ClN7O2/c1-32-11-13-33(14-12-32)10-8-28-24(35)20-17-30-25(34-9-7-26(18-34)5-6-26)31-23(20)29-16-19-3-4-22(36-2)21(27)15-19/h3-4,15,17H,5-14,16,18H2,1-2H3,(H,28,35)(H,29,30,31)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235742
PNG
(US9359371, 11)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H30ClN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18-
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235745
PNG
(US9359371, 18)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CCC3(CCN(C)C3)C2)cc1Cl
Show InChI InChI=1S/C26H31ClN8O2/c1-34-10-6-26(16-34)7-11-35(17-26)25-32-14-19(24(36)31-15-22-28-8-3-9-29-22)23(33-25)30-13-18-4-5-21(37-2)20(27)12-18/h3-5,8-9,12,14H,6-7,10-11,13,15-17H2,1-2H3,(H,31,36)(H,30,32,33)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235737
PNG
(US9359371, 5)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccc(F)cc2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C25H25ClFN5O2/c1-34-22-7-4-16(8-21(22)26)11-28-23-20(24(33)29-10-15-2-5-19(27)6-3-15)12-30-25(31-23)32-13-17-9-18(17)14-32/h2-8,12,17-18H,9-11,13-14H2,1H3,(H,29,33)(H,28,30,31)
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235761
PNG
(US9359371, 44)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](N)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C25H33ClN6O2/c1-34-21-7-2-16(12-20(21)26)13-28-22-19(23(33)30-18-5-3-17(27)4-6-18)14-29-24(31-22)32-11-10-25(15-32)8-9-25/h2,7,12,14,17-18H,3-6,8-11,13,15,27H2,1H3,(H,30,33)(H,28,29,31)/t17-,18-
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XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%