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Patent code US9365511

Compile Data Set for Download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50088162
PNG
(CHEMBL3427228 | US9365511, 4)
Show SMILES CCOC(=O)COCc1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1
Show InChI InChI=1S/C24H31NO3/c1-3-28-24(26)18-27-17-21-8-12-23(13-9-21)22-10-6-20(7-11-22)14-16-25-15-4-5-19(25)2/h6-13,19H,3-5,14-18H2,1-2H3/t19-/m1/s1
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n/an/a 0.670n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50088061
PNG
(CHEMBL3427242 | US9365511, 37)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(Cc2nnn[nH]2)cc1
Show InChI InChI=1S/C21H25N5/c1-16-3-2-13-26(16)14-12-17-4-8-19(9-5-17)20-10-6-18(7-11-20)15-21-22-24-25-23-21/h4-11,16H,2-3,12-15H2,1H3,(H,22,23,24,25)/t16-/m1/s1
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n/an/a 0.780n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM235922
PNG
(US9365511, 18)
Show SMILES C[C@H](NC(=O)CCc1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1)C(O)=O
Show InChI InChI=1S/C25H32N2O3/c1-18-4-3-16-27(18)17-15-21-7-12-23(13-8-21)22-10-5-20(6-11-22)9-14-24(28)26-19(2)25(29)30/h5-8,10-13,18-19H,3-4,9,14-17H2,1-2H3,(H,26,28)(H,29,30)/t18-,19+/m1/s1
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n/an/a 0.790n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50088141
PNG
(CHEMBL3427230 | US9365511, 7)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(CCn2cnnn2)cc1
Show InChI InChI=1S/C22H27N5/c1-18-3-2-14-26(18)15-12-19-4-8-21(9-5-19)22-10-6-20(7-11-22)13-16-27-17-23-24-25-27/h4-11,17-18H,2-3,12-16H2,1H3/t18-/m1/s1
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n/an/a 0.930n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM235919
PNG
(US9365511, 12)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(CCC(=O)NC(C)(C)C(=O)OC(C)(C)C)cc1
Show InChI InChI=1S/C30H42N2O3/c1-22-8-7-20-32(22)21-19-24-11-16-26(17-12-24)25-14-9-23(10-15-25)13-18-27(33)31-30(5,6)28(34)35-29(2,3)4/h9-12,14-17,22H,7-8,13,18-21H2,1-6H3,(H,31,33)/t22-/m1/s1
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n/an/a 0.950n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM235928
PNG
(US9365511, 35)
Show SMILES CCOC(=O)C1CCN(CC1)C(=O)CCc1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1
Show InChI InChI=1S/C30H40N2O3/c1-3-35-30(34)28-17-21-32(22-18-28)29(33)15-10-24-6-11-26(12-7-24)27-13-8-25(9-14-27)16-20-31-19-4-5-23(31)2/h6-9,11-14,23,28H,3-5,10,15-22H2,1-2H3/t23-/m1/s1
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n/an/a 0.960n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50088058
PNG
(CHEMBL3427245 | US9365511, 45)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(CCCC(O)=O)cc1
Show InChI InChI=1S/C23H29NO2/c1-18-4-3-16-24(18)17-15-20-9-13-22(14-10-20)21-11-7-19(8-12-21)5-2-6-23(25)26/h7-14,18H,2-6,15-17H2,1H3,(H,25,26)/t18-/m1/s1
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ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM235924
PNG
(US9365511, 24)
Show SMILES COC(=O)CNC(=O)CCc1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1
Show InChI InChI=1S/C25H32N2O3/c1-19-4-3-16-27(19)17-15-21-7-12-23(13-8-21)22-10-5-20(6-11-22)9-14-24(28)26-18-25(29)30-2/h5-8,10-13,19H,3-4,9,14-18H2,1-2H3,(H,26,28)/t19-/m1/s1
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n/an/a 0.990n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50088139
PNG
(CHEMBL3427232 | US9365511, 9)
Show SMILES COC(=O)CCc1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1
Show InChI InChI=1S/C23H29NO2/c1-18-4-3-16-24(18)17-15-20-7-12-22(13-8-20)21-10-5-19(6-11-21)9-14-23(25)26-2/h5-8,10-13,18H,3-4,9,14-17H2,1-2H3/t18-/m1/s1
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ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM235929
PNG
(US9365511, 38)
Show SMILES COC(=O)C(C)(C)NC(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1
Show InChI InChI=1S/C25H32N2O3/c1-18-6-5-16-27(18)17-15-19-7-9-20(10-8-19)21-11-13-22(14-12-21)23(28)26-25(2,3)24(29)30-4/h7-14,18H,5-6,15-17H2,1-4H3,(H,26,28)/t18-/m1/s1
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ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50088140
PNG
(CHEMBL3427231 | US9365511, 8)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(CCn2ncnn2)cc1
Show InChI InChI=1S/C22H27N5/c1-18-3-2-14-26(18)15-12-19-4-8-21(9-5-19)22-10-6-20(7-11-22)13-16-27-24-17-23-25-27/h4-11,17-18H,2-3,12-16H2,1H3/t18-/m1/s1
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ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM235921
PNG
(US9365511, 16)
Show SMILES COC(=O)CCCNC(=O)C1(CCCC1)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1
Show InChI InChI=1S/C30H40N2O3/c1-23-7-6-21-32(23)22-17-24-9-11-25(12-10-24)26-13-15-27(16-14-26)30(18-3-4-19-30)29(34)31-20-5-8-28(33)35-2/h9-16,23H,3-8,17-22H2,1-2H3,(H,31,34)/t23-/m1/s1
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ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50088137
PNG
(CHEMBL3427234 | US9365511, 11)
Show SMILES CCOC(=O)CCc1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1
Show InChI InChI=1S/C24H31NO2/c1-3-27-24(26)15-10-20-6-11-22(12-7-20)23-13-8-21(9-14-23)16-18-25-17-4-5-19(25)2/h6-9,11-14,19H,3-5,10,15-18H2,1-2H3/t19-/m1/s1
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ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM235926
PNG
(US9365511, 27)
Show SMILES COC(=O)CNC(=O)C1(CCCC1)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1
Show InChI InChI=1S/C28H36N2O3/c1-21-6-5-18-30(21)19-15-22-7-9-23(10-8-22)24-11-13-25(14-12-24)28(16-3-4-17-28)27(32)29-20-26(31)33-2/h7-14,21H,3-6,15-20H2,1-2H3,(H,29,32)/t21-/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM235927
PNG
(US9365511, 33)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)C1(CCCC1)C(=O)NCCCC(O)=O
Show InChI InChI=1S/C29H38N2O3/c1-22-6-5-20-31(22)21-16-23-8-10-24(11-9-23)25-12-14-26(15-13-25)29(17-2-3-18-29)28(34)30-19-4-7-27(32)33/h8-15,22H,2-7,16-21H2,1H3,(H,30,34)(H,32,33)/t22-/m1/s1
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n/an/a 2.10n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM235920
PNG
(US9365511, 13)
Show SMILES C[C@H](NC(=O)CCc1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H40N2O3/c1-21-7-6-19-31(21)20-18-24-10-15-26(16-11-24)25-13-8-23(9-14-25)12-17-27(32)30-22(2)28(33)34-29(3,4)5/h8-11,13-16,21-22H,6-7,12,17-20H2,1-5H3,(H,30,32)/t21-,22+/m1/s1
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n/an/a 2.10n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50088163
PNG
(CHEMBL3427227 | US9365511, 3)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C22H27NO2/c1-17-3-2-15-23(17)16-14-19-6-11-21(12-7-19)20-9-4-18(5-10-20)8-13-22(24)25/h4-7,9-12,17H,2-3,8,13-16H2,1H3,(H,24,25)/t17-/m1/s1
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ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM235930
PNG
(US9365511, 43)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C23H28N2O3/c1-17-3-2-15-25(17)16-13-18-4-6-19(7-5-18)20-8-10-21(11-9-20)23(28)24-14-12-22(26)27/h4-11,17H,2-3,12-16H2,1H3,(H,24,28)(H,26,27)/t17-/m1/s1
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ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM235923
PNG
(US9365511, 20)
Show SMILES CCOC(=O)[C@H]1CCCC[C@H]1NC(=O)C1(CCCC1)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1
Show InChI InChI=1S/C34H46N2O3/c1-3-39-32(37)30-10-4-5-11-31(30)35-33(38)34(21-6-7-22-34)29-18-16-28(17-19-29)27-14-12-26(13-15-27)20-24-36-23-8-9-25(36)2/h12-19,25,30-31H,3-11,20-24H2,1-2H3,(H,35,38)/t25-,30+,31-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50088138
PNG
(CHEMBL3427233 | US9365511, 10)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)C(C)(C)C(O)=O
Show InChI InChI=1S/C23H29NO2/c1-17-5-4-15-24(17)16-14-18-6-8-19(9-7-18)20-10-12-21(13-11-20)23(2,3)22(25)26/h6-13,17H,4-5,14-16H2,1-3H3,(H,25,26)/t17-/m1/s1
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n/an/a 3.10n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50088132
PNG
(CHEMBL3427239 | US9365511, 25)
Show SMILES COC(=O)C1(CCCC1)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1
Show InChI InChI=1S/C26H33NO2/c1-20-6-5-18-27(20)19-15-21-7-9-22(10-8-21)23-11-13-24(14-12-23)26(25(28)29-2)16-3-4-17-26/h7-14,20H,3-6,15-19H2,1-2H3/t20-/m1/s1
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n/an/a 3.30n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50088166
PNG
(CHEMBL3427225 | US9365511, 1)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C20H23NO2/c1-15-3-2-13-21(15)14-12-16-4-6-17(7-5-16)18-8-10-19(11-9-18)20(22)23/h4-11,15H,2-3,12-14H2,1H3,(H,22,23)/t15-/m1/s1
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n/an/a 3.80n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


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More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM235925
PNG
(US9365511, 26)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(CCC(=O)NCC(=O)OC(C)(C)C)cc1
Show InChI InChI=1S/C28H38N2O3/c1-21-6-5-18-30(21)19-17-23-9-14-25(15-10-23)24-12-7-22(8-13-24)11-16-26(31)29-20-27(32)33-28(2,3)4/h7-10,12-15,21H,5-6,11,16-20H2,1-4H3,(H,29,31)/t21-/m1/s1
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n/an/a 3.80n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50088160
PNG
(CHEMBL3427229 | US9365511, 5)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(COCC(O)=O)cc1
Show InChI InChI=1S/C22H27NO3/c1-17-3-2-13-23(17)14-12-18-4-8-20(9-5-18)21-10-6-19(7-11-21)15-26-16-22(24)25/h4-11,17H,2-3,12-16H2,1H3,(H,24,25)/t17-/m1/s1
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n/an/a 5.5n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM235931
PNG
(US9365511, 44)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(CCc2nnn[nH]2)cc1
Show InChI InChI=1S/C22H27N5/c1-17-3-2-15-27(17)16-14-19-6-11-21(12-7-19)20-9-4-18(5-10-20)8-13-22-23-25-26-24-22/h4-7,9-12,17H,2-3,8,13-16H2,1H3,(H,23,24,25,26)/t17-/m1/s1
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n/an/a 6.90n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50088165
PNG
(CHEMBL3427226 | US9365511, 2)
Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C21H25NO2/c1-16-3-2-13-22(16)14-12-17-4-8-19(9-5-17)20-10-6-18(7-11-20)15-21(23)24/h4-11,16H,2-3,12-15H2,1H3,(H,23,24)/t16-/m1/s1
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n/an/a 8.10n/an/an/an/an/an/a



ARENA PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%