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Patent code US9365529

Compile Data Set for Download or QSAR
Found 68 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ADAM17


(Homo sapiens (Human))
BDBM50181008
PNG
((S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynyloxy)phenyls...)
Show SMILES CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCC#CCO)cc1
Show InChI InChI=1S/C17H22N2O6S2/c1-17(2)15(16(21)18-22)19(9-12-26-17)27(23,24)14-7-5-13(6-8-14)25-11-4-3-10-20/h5-8,15,20,22H,9-12H2,1-2H3,(H,18,21)/t15-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM50181008
PNG
((S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynyloxy)phenyls...)
Show SMILES CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCC#CCO)cc1
Show InChI InChI=1S/C17H22N2O6S2/c1-17(2)15(16(21)18-22)19(9-12-26-17)27(23,24)14-7-5-13(6-8-14)25-11-4-3-10-20/h5-8,15,20,22H,9-12H2,1-2H3,(H,18,21)/t15-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113593
PNG
(US8633196, 26 | US9365529, 26)
Show SMILES CC(C)S(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C27H35N5O7S2/c1-19(2)41(37,38)32-14-12-31(13-15-32)26(27(33)30-34)17-28-40(35,36)23-10-8-22(9-11-23)39-18-21-16-20(3)29-25-7-5-4-6-24(21)25/h4-11,16,19,26,28,34H,12-15,17-18H2,1-3H3,(H,30,33)/t26-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113592
PNG
(US8633196, 24 | US9365529, 24)
Show SMILES CC(C)CS(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C28H37N5O7S2/c1-20(2)19-41(36,37)33-14-12-32(13-15-33)27(28(34)31-35)17-29-42(38,39)24-10-8-23(9-11-24)40-18-22-16-21(3)30-26-7-5-4-6-25(22)26/h4-11,16,20,27,29,35H,12-15,17-19H2,1-3H3,(H,31,34)/t27-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113577
PNG
(US8633196, 14 | US8633196, 5 | US9365529, 5)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(CC2)S(C)(=O)=O)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C25H31N5O7S2/c1-18-15-19(22-5-3-4-6-23(22)27-18)17-37-20-7-9-21(10-8-20)39(35,36)26-16-24(25(31)28-32)29-11-13-30(14-12-29)38(2,33)34/h3-10,15,24,26,32H,11-14,16-17H2,1-2H3,(H,28,31)/t24-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113583
PNG
(US8633196, 11 | US9365529, 11)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2ccnc(c2)-c2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C26H31N5O7S2/c1-39(34,35)31-15-13-30(14-16-31)25(26(32)29-33)18-28-40(36,37)23-9-7-22(8-10-23)38-19-20-11-12-27-24(17-20)21-5-3-2-4-6-21/h2-12,17,25,28,33H,13-16,18-19H2,1H3,(H,29,32)/t25-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113574
PNG
(US8633196, 2 | US9365529, 2)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)NC[C@H](N1CCN(CC1)S(C)(=O)=O)C(=O)NO
Show InChI InChI=1S/C18H26N4O7S2/c1-3-4-13-29-15-5-7-16(8-6-15)31(27,28)19-14-17(18(23)20-24)21-9-11-22(12-10-21)30(2,25)26/h5-8,17,19,24H,9-14H2,1-2H3,(H,20,23)/t17-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113593
PNG
(US8633196, 26 | US9365529, 26)
Show SMILES CC(C)S(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C27H35N5O7S2/c1-19(2)41(37,38)32-14-12-31(13-15-32)26(27(33)30-34)17-28-40(35,36)23-10-8-22(9-11-23)39-18-21-16-20(3)29-25-7-5-4-6-24(21)25/h4-11,16,19,26,28,34H,12-15,17-18H2,1-3H3,(H,30,33)/t26-/m0/s1
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n/an/a 33n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113589
PNG
(US8633196, 19 | US9365529, 19)
Show SMILES CCN1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C26H33N5O5S/c1-3-30-12-14-31(15-13-30)25(26(32)29-33)17-27-37(34,35)22-10-8-21(9-11-22)36-18-20-16-19(2)28-24-7-5-4-6-23(20)24/h4-11,16,25,27,33H,3,12-15,17-18H2,1-2H3,(H,29,32)/t25-/m0/s1
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n/an/a 41n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113582
PNG
(US8633196, 10 | US9365529, 10)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(CC2)C(=O)OCc2ccccc2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C32H35N5O7S/c1-23-19-25(28-9-5-6-10-29(28)34-23)22-43-26-11-13-27(14-12-26)45(41,42)33-20-30(31(38)35-40)36-15-17-37(18-16-36)32(39)44-21-24-7-3-2-4-8-24/h2-14,19,30,33,40H,15-18,20-22H2,1H3,(H,35,38)/t30-/m0/s1
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n/an/a 47n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113578
PNG
(US8633196, 6 | US9365529, 6)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cccc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C25H30N4O7S2/c1-37(32,33)29-15-13-28(14-16-29)24(25(30)27-31)17-26-38(34,35)22-11-9-21(10-12-22)36-18-20-7-4-6-19-5-2-3-8-23(19)20/h2-12,24,26,31H,13-18H2,1H3,(H,27,30)/t24-/m0/s1
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n/an/a 52n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113591
PNG
(US8633196, 23 | US9365529, 23)
Show SMILES CC(C)C(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C28H35N5O6S/c1-19(2)28(35)33-14-12-32(13-15-33)26(27(34)31-36)17-29-40(37,38)23-10-8-22(9-11-23)39-18-21-16-20(3)30-25-7-5-4-6-24(21)25/h4-11,16,19,26,29,36H,12-15,17-18H2,1-3H3,(H,31,34)/t26-/m0/s1
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n/an/a 53n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113587
PNG
(US8633196, 17 | US9365529, 17)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(Cc3ccccc3)CC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C31H35N5O5S/c1-23-19-25(28-9-5-6-10-29(28)33-23)22-41-26-11-13-27(14-12-26)42(39,40)32-20-30(31(37)34-38)36-17-15-35(16-18-36)21-24-7-3-2-4-8-24/h2-14,19,30,32,38H,15-18,20-22H2,1H3,(H,34,37)/t30-/m0/s1
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n/an/a 62n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113590
PNG
(US8633196, 21 | US9365529, 21)
Show SMILES Cc1ccc(CN2CCN(CC2)[C@@H](CNS(=O)(=O)c2ccc(OCc3cc(C)nc4ccccc34)cc2)C(=O)NO)cc1
Show InChI InChI=1S/C32H37N5O5S/c1-23-7-9-25(10-8-23)21-36-15-17-37(18-16-36)31(32(38)35-39)20-33-43(40,41)28-13-11-27(12-14-28)42-22-26-19-24(2)34-30-6-4-3-5-29(26)30/h3-14,19,31,33,39H,15-18,20-22H2,1-2H3,(H,35,38)/t31-/m0/s1
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n/an/a 63n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113577
PNG
(US8633196, 14 | US8633196, 5 | US9365529, 5)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(CC2)S(C)(=O)=O)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C25H31N5O7S2/c1-18-15-19(22-5-3-4-6-23(22)27-18)17-37-20-7-9-21(10-8-20)39(35,36)26-16-24(25(31)28-32)29-11-13-30(14-12-29)38(2,33)34/h3-10,15,24,26,32H,11-14,16-17H2,1-2H3,(H,28,31)/t24-/m0/s1
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n/an/a 64n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113588
PNG
(US8633196, 18 | US9365529, 18)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(Cc3ccc(F)cc3)CC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C31H34FN5O5S/c1-22-18-24(28-4-2-3-5-29(28)34-22)21-42-26-10-12-27(13-11-26)43(40,41)33-19-30(31(38)35-39)37-16-14-36(15-17-37)20-23-6-8-25(32)9-7-23/h2-13,18,30,33,39H,14-17,19-21H2,1H3,(H,35,38)/t30-/m0/s1
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n/an/a 67n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)


(Homo sapiens (Human))
BDBM50181008
PNG
((S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynyloxy)phenyls...)
Show SMILES CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCC#CCO)cc1
Show InChI InChI=1S/C17H22N2O6S2/c1-17(2)15(16(21)18-22)19(9-12-26-17)27(23,24)14-7-5-13(6-8-14)25-11-4-3-10-20/h5-8,15,20,22H,9-12H2,1-2H3,(H,18,21)/t15-/m0/s1
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n/an/a 71n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50181008
PNG
((S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynyloxy)phenyls...)
Show SMILES CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCC#CCO)cc1
Show InChI InChI=1S/C17H22N2O6S2/c1-17(2)15(16(21)18-22)19(9-12-26-17)27(23,24)14-7-5-13(6-8-14)25-11-4-3-10-20/h5-8,15,20,22H,9-12H2,1-2H3,(H,18,21)/t15-/m0/s1
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n/an/a 82n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM50181008
PNG
((S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynyloxy)phenyls...)
Show SMILES CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCC#CCO)cc1
Show InChI InChI=1S/C17H22N2O6S2/c1-17(2)15(16(21)18-22)19(9-12-26-17)27(23,24)14-7-5-13(6-8-14)25-11-4-3-10-20/h5-8,15,20,22H,9-12H2,1-2H3,(H,18,21)/t15-/m0/s1
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n/an/a 85n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113592
PNG
(US8633196, 24 | US9365529, 24)
Show SMILES CC(C)CS(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C28H37N5O7S2/c1-20(2)19-41(36,37)33-14-12-32(13-15-33)27(28(34)31-35)17-29-42(38,39)24-10-8-23(9-11-24)40-18-22-16-21(3)30-26-7-5-4-6-25(22)26/h4-11,16,20,27,29,35H,12-15,17-19H2,1-3H3,(H,31,34)/t27-/m0/s1
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n/an/a 86n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113573
PNG
(US8633196, 1 | US9365529, 1)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)CNCC(N1CCN(CC1)S(C)(=O)=O)C(=O)NO
Show InChI InChI=1S/C19H28N4O7S2/c1-3-4-13-30-16-5-7-17(8-6-16)32(28,29)15-20-14-18(19(24)21-25)22-9-11-23(12-10-22)31(2,26)27/h5-8,18,20,25H,9-15H2,1-2H3,(H,21,24)
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n/an/a 87n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113584
PNG
(US8633196, 13 | US9365529, 13)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCNCC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C24H29N5O5S/c1-17-14-18(21-4-2-3-5-22(21)27-17)16-34-19-6-8-20(9-7-19)35(32,33)26-15-23(24(30)28-31)29-12-10-25-11-13-29/h2-9,14,23,25-26,31H,10-13,15-16H2,1H3,(H,28,30)/t23-/m0/s1
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n/an/a 108n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113580
PNG
(US8633196, 8 | US9365529, 8)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cccc(c2)C#N)cc1)C(=O)NO
Show InChI InChI=1S/C22H27N5O7S2/c1-35(30,31)27-11-9-26(10-12-27)21(22(28)25-29)15-24-36(32,33)20-7-5-19(6-8-20)34-16-18-4-2-3-17(13-18)14-23/h2-8,13,21,24,29H,9-12,15-16H2,1H3,(H,25,28)/t21-/m0/s1
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n/an/a 127n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM235932
PNG
(US9365529, 20)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C32H34F3N5O5S/c1-22-18-24(28-4-2-3-5-29(28)37-22)21-45-26-10-12-27(13-11-26)46(43,44)36-19-30(31(41)38-42)40-16-14-39(15-17-40)20-23-6-8-25(9-7-23)32(33,34)35/h2-13,18,30,36,42H,14-17,19-21H2,1H3,(H,38,41)/t30-/m0/s1
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n/an/a 140n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50181008
PNG
((S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynyloxy)phenyls...)
Show SMILES CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCC#CCO)cc1
Show InChI InChI=1S/C17H22N2O6S2/c1-17(2)15(16(21)18-22)19(9-12-26-17)27(23,24)14-7-5-13(6-8-14)25-11-4-3-10-20/h5-8,15,20,22H,9-12H2,1-2H3,(H,18,21)/t15-/m0/s1
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n/an/a 145n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113581
PNG
(US8633196, 9 | US9365529, 9)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2ccc(cc2)C#N)cc1)C(=O)NO
Show InChI InChI=1S/C22H27N5O7S2/c1-35(30,31)27-12-10-26(11-13-27)21(22(28)25-29)15-24-36(32,33)20-8-6-19(7-9-20)34-16-18-4-2-17(14-23)3-5-18/h2-9,21,24,29H,10-13,15-16H2,1H3,(H,25,28)/t21-/m0/s1
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n/an/a 147n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113586
PNG
(US8633196, 16 | US9365529, 16)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2ccnc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C24H29N5O7S2/c1-37(32,33)29-14-12-28(13-15-29)23(24(30)27-31)16-26-38(34,35)20-8-6-19(7-9-20)36-17-18-10-11-25-22-5-3-2-4-21(18)22/h2-11,23,26,31H,12-17H2,1H3,(H,27,30)/t23-/m0/s1
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n/an/a 168n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM113576
PNG
(US8633196, 4 | US9365529, 4)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@@H](CNCS(=O)(=O)c1ccc(OCc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C22H30N4O7S2/c1-34(29,30)26-13-11-25(12-14-26)21(22(27)24-28)15-23-17-35(31,32)20-9-7-19(8-10-20)33-16-18-5-3-2-4-6-18/h2-10,21,23,28H,11-17H2,1H3,(H,24,27)/t21-/m0/s1
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n/an/a 497n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The TACE enzyme is an internal production (carried out according to the publication protein Eng Des Sel 2006, 19, 155-161) and is added so as to have...


Citation and Details
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM113593
PNG
(US8633196, 26 | US9365529, 26)
Show SMILES CC(C)S(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C27H35N5O7S2/c1-19(2)41(37,38)32-14-12-31(13-15-32)26(27(33)30-34)17-28-40(35,36)23-10-8-22(9-11-23)39-18-21-16-20(3)29-25-7-5-4-6-24(21)25/h4-11,16,19,26,28,34H,12-15,17-18H2,1-3H3,(H,30,33)/t26-/m0/s1
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n/an/a 574n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM113588
PNG
(US8633196, 18 | US9365529, 18)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(Cc3ccc(F)cc3)CC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C31H34FN5O5S/c1-22-18-24(28-4-2-3-5-29(28)34-22)21-42-26-10-12-27(13-11-26)43(40,41)33-19-30(31(38)35-39)37-16-14-36(15-17-37)20-23-6-8-25(32)9-7-23/h2-13,18,30,33,39H,14-17,19-21H2,1H3,(H,35,38)/t30-/m0/s1
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n/an/a 670n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM113588
PNG
(US8633196, 18 | US9365529, 18)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(Cc3ccc(F)cc3)CC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C31H34FN5O5S/c1-22-18-24(28-4-2-3-5-29(28)34-22)21-42-26-10-12-27(13-11-26)43(40,41)33-19-30(31(38)35-39)37-16-14-36(15-17-37)20-23-6-8-25(32)9-7-23/h2-13,18,30,33,39H,14-17,19-21H2,1H3,(H,35,38)/t30-/m0/s1
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n/an/a 849n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM113590
PNG
(US8633196, 21 | US9365529, 21)
Show SMILES Cc1ccc(CN2CCN(CC2)[C@@H](CNS(=O)(=O)c2ccc(OCc3cc(C)nc4ccccc34)cc2)C(=O)NO)cc1
Show InChI InChI=1S/C32H37N5O5S/c1-23-7-9-25(10-8-23)21-36-15-17-37(18-16-36)31(32(38)35-39)20-33-43(40,41)28-13-11-27(12-14-28)42-22-26-19-24(2)34-30-6-4-3-5-29(26)30/h3-14,19,31,33,39H,15-18,20-22H2,1-2H3,(H,35,38)/t31-/m0/s1
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n/an/a 887n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM113593
PNG
(US8633196, 26 | US9365529, 26)
Show SMILES CC(C)S(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C27H35N5O7S2/c1-19(2)41(37,38)32-14-12-31(13-15-32)26(27(33)30-34)17-28-40(35,36)23-10-8-22(9-11-23)39-18-21-16-20(3)29-25-7-5-4-6-24(21)25/h4-11,16,19,26,28,34H,12-15,17-18H2,1-3H3,(H,30,33)/t26-/m0/s1
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n/an/a 969n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM113591
PNG
(US8633196, 23 | US9365529, 23)
Show SMILES CC(C)C(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C28H35N5O6S/c1-19(2)28(35)33-14-12-32(13-15-33)26(27(34)31-36)17-29-40(37,38)23-10-8-22(9-11-23)39-18-21-16-20(3)30-25-7-5-4-6-24(21)25/h4-11,16,19,26,29,36H,12-15,17-18H2,1-3H3,(H,31,34)/t26-/m0/s1
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n/an/a 1.07E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM113590
PNG
(US8633196, 21 | US9365529, 21)
Show SMILES Cc1ccc(CN2CCN(CC2)[C@@H](CNS(=O)(=O)c2ccc(OCc3cc(C)nc4ccccc34)cc2)C(=O)NO)cc1
Show InChI InChI=1S/C32H37N5O5S/c1-23-7-9-25(10-8-23)21-36-15-17-37(18-16-36)31(32(38)35-39)20-33-43(40,41)28-13-11-27(12-14-28)42-22-26-19-24(2)34-30-6-4-3-5-29(26)30/h3-14,19,31,33,39H,15-18,20-22H2,1-2H3,(H,35,38)/t31-/m0/s1
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n/an/a 1.17E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM113589
PNG
(US8633196, 19 | US9365529, 19)
Show SMILES CCN1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C26H33N5O5S/c1-3-30-12-14-31(15-13-30)25(26(32)29-33)17-27-37(34,35)22-10-8-21(9-11-22)36-18-20-16-19(2)28-24-7-5-4-6-23(20)24/h4-11,16,25,27,33H,3,12-15,17-18H2,1-2H3,(H,29,32)/t25-/m0/s1
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n/an/a 1.77E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM113592
PNG
(US8633196, 24 | US9365529, 24)
Show SMILES CC(C)CS(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C28H37N5O7S2/c1-20(2)19-41(36,37)33-14-12-32(13-15-33)27(28(34)31-35)17-29-42(38,39)24-10-8-23(9-11-24)40-18-22-16-21(3)30-26-7-5-4-6-25(22)26/h4-11,16,20,27,29,35H,12-15,17-19H2,1-3H3,(H,31,34)/t27-/m0/s1
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n/an/a 1.88E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM113592
PNG
(US8633196, 24 | US9365529, 24)
Show SMILES CC(C)CS(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C28H37N5O7S2/c1-20(2)19-41(36,37)33-14-12-32(13-15-33)27(28(34)31-35)17-29-42(38,39)24-10-8-23(9-11-24)40-18-22-16-21(3)30-26-7-5-4-6-25(22)26/h4-11,16,20,27,29,35H,12-15,17-19H2,1-3H3,(H,31,34)/t27-/m0/s1
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n/an/a 2.06E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM113591
PNG
(US8633196, 23 | US9365529, 23)
Show SMILES CC(C)C(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C28H35N5O6S/c1-19(2)28(35)33-14-12-32(13-15-33)26(27(34)31-36)17-29-40(37,38)23-10-8-22(9-11-23)39-18-21-16-20(3)30-25-7-5-4-6-24(21)25/h4-11,16,19,26,29,36H,12-15,17-18H2,1-3H3,(H,31,34)/t26-/m0/s1
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n/an/a 2.22E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM113589
PNG
(US8633196, 19 | US9365529, 19)
Show SMILES CCN1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C26H33N5O5S/c1-3-30-12-14-31(15-13-30)25(26(32)29-33)17-27-37(34,35)22-10-8-21(9-11-22)36-18-20-16-19(2)28-24-7-5-4-6-23(20)24/h4-11,16,25,27,33H,3,12-15,17-18H2,1-2H3,(H,29,32)/t25-/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM113589
PNG
(US8633196, 19 | US9365529, 19)
Show SMILES CCN1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C26H33N5O5S/c1-3-30-12-14-31(15-13-30)25(26(32)29-33)17-27-37(34,35)22-10-8-21(9-11-22)36-18-20-16-19(2)28-24-7-5-4-6-23(20)24/h4-11,16,25,27,33H,3,12-15,17-18H2,1-2H3,(H,29,32)/t25-/m0/s1
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n/an/a 3.05E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM113577
PNG
(US8633196, 14 | US8633196, 5 | US9365529, 5)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(CC2)S(C)(=O)=O)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C25H31N5O7S2/c1-18-15-19(22-5-3-4-6-23(22)27-18)17-37-20-7-9-21(10-8-20)39(35,36)26-16-24(25(31)28-32)29-11-13-30(14-12-29)38(2,33)34/h3-10,15,24,26,32H,11-14,16-17H2,1-2H3,(H,28,31)/t24-/m0/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM235932
PNG
(US9365529, 20)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C32H34F3N5O5S/c1-22-18-24(28-4-2-3-5-29(28)37-22)21-45-26-10-12-27(13-11-26)46(43,44)36-19-30(31(41)38-42)40-16-14-39(15-17-40)20-23-6-8-25(9-7-23)32(33,34)35/h2-13,18,30,36,42H,14-17,19-21H2,1H3,(H,38,41)/t30-/m0/s1
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n/an/a 3.94E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM235932
PNG
(US9365529, 20)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C32H34F3N5O5S/c1-22-18-24(28-4-2-3-5-29(28)37-22)21-45-26-10-12-27(13-11-26)46(43,44)36-19-30(31(41)38-42)40-16-14-39(15-17-40)20-23-6-8-25(9-7-23)32(33,34)35/h2-13,18,30,36,42H,14-17,19-21H2,1H3,(H,38,41)/t30-/m0/s1
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n/an/a 4.78E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM113577
PNG
(US8633196, 14 | US8633196, 5 | US9365529, 5)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(CC2)S(C)(=O)=O)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C25H31N5O7S2/c1-18-15-19(22-5-3-4-6-23(22)27-18)17-37-20-7-9-21(10-8-20)39(35,36)26-16-24(25(31)28-32)29-11-13-30(14-12-29)38(2,33)34/h3-10,15,24,26,32H,11-14,16-17H2,1-2H3,(H,28,31)/t24-/m0/s1
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n/an/a 5.10E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM113588
PNG
(US8633196, 18 | US9365529, 18)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(Cc3ccc(F)cc3)CC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C31H34FN5O5S/c1-22-18-24(28-4-2-3-5-29(28)34-22)21-42-26-10-12-27(13-11-26)43(40,41)33-19-30(31(38)35-39)37-16-14-36(15-17-37)20-23-6-8-25(32)9-7-23/h2-13,18,30,33,39H,14-17,19-21H2,1H3,(H,35,38)/t30-/m0/s1
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n/an/a 9.25E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM113592
PNG
(US8633196, 24 | US9365529, 24)
Show SMILES CC(C)CS(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C28H37N5O7S2/c1-20(2)19-41(36,37)33-14-12-32(13-15-33)27(28(34)31-35)17-29-42(38,39)24-10-8-23(9-11-24)40-18-22-16-21(3)30-26-7-5-4-6-25(22)26/h4-11,16,20,27,29,35H,12-15,17-19H2,1-3H3,(H,31,34)/t27-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)


(Homo sapiens (Human))
BDBM113593
PNG
(US8633196, 26 | US9365529, 26)
Show SMILES CC(C)S(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C27H35N5O7S2/c1-19(2)41(37,38)32-14-12-31(13-15-32)26(27(33)30-34)17-28-40(35,36)23-10-8-22(9-11-23)39-18-21-16-20(3)29-25-7-5-4-6-24(21)25/h4-11,16,19,26,28,34H,12-15,17-18H2,1-3H3,(H,30,33)/t26-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)


(Homo sapiens (Human))
BDBM113590
PNG
(US8633196, 21 | US9365529, 21)
Show SMILES Cc1ccc(CN2CCN(CC2)[C@@H](CNS(=O)(=O)c2ccc(OCc3cc(C)nc4ccccc34)cc2)C(=O)NO)cc1
Show InChI InChI=1S/C32H37N5O5S/c1-23-7-9-25(10-8-23)21-36-15-17-37(18-16-36)31(32(38)35-39)20-33-43(40,41)28-13-11-27(12-14-28)42-22-26-19-24(2)34-30-6-4-3-5-29(26)30/h3-14,19,31,33,39H,15-18,20-22H2,1-2H3,(H,35,38)/t31-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM113591
PNG
(US8633196, 23 | US9365529, 23)
Show SMILES CC(C)C(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C28H35N5O6S/c1-19(2)28(35)33-14-12-32(13-15-33)26(27(34)31-36)17-29-40(37,38)23-10-8-22(9-11-23)39-18-21-16-20(3)30-25-7-5-4-6-24(21)25/h4-11,16,19,26,29,36H,12-15,17-18H2,1-3H3,(H,31,34)/t26-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM113590
PNG
(US8633196, 21 | US9365529, 21)
Show SMILES Cc1ccc(CN2CCN(CC2)[C@@H](CNS(=O)(=O)c2ccc(OCc3cc(C)nc4ccccc34)cc2)C(=O)NO)cc1
Show InChI InChI=1S/C32H37N5O5S/c1-23-7-9-25(10-8-23)21-36-15-17-37(18-16-36)31(32(38)35-39)20-33-43(40,41)28-13-11-27(12-14-28)42-22-26-19-24(2)34-30-6-4-3-5-29(26)30/h3-14,19,31,33,39H,15-18,20-22H2,1-2H3,(H,35,38)/t31-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM113593
PNG
(US8633196, 26 | US9365529, 26)
Show SMILES CC(C)S(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C27H35N5O7S2/c1-19(2)41(37,38)32-14-12-31(13-15-32)26(27(33)30-34)17-28-40(35,36)23-10-8-22(9-11-23)39-18-21-16-20(3)29-25-7-5-4-6-24(21)25/h4-11,16,19,26,28,34H,12-15,17-18H2,1-3H3,(H,30,33)/t26-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM113592
PNG
(US8633196, 24 | US9365529, 24)
Show SMILES CC(C)CS(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C28H37N5O7S2/c1-20(2)19-41(36,37)33-14-12-32(13-15-33)27(28(34)31-35)17-29-42(38,39)24-10-8-23(9-11-24)40-18-22-16-21(3)30-26-7-5-4-6-25(22)26/h4-11,16,20,27,29,35H,12-15,17-19H2,1-3H3,(H,31,34)/t27-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)


(Homo sapiens (Human))
BDBM113577
PNG
(US8633196, 14 | US8633196, 5 | US9365529, 5)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(CC2)S(C)(=O)=O)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C25H31N5O7S2/c1-18-15-19(22-5-3-4-6-23(22)27-18)17-37-20-7-9-21(10-8-20)39(35,36)26-16-24(25(31)28-32)29-11-13-30(14-12-29)38(2,33)34/h3-10,15,24,26,32H,11-14,16-17H2,1-2H3,(H,28,31)/t24-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM113591
PNG
(US8633196, 23 | US9365529, 23)
Show SMILES CC(C)C(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C28H35N5O6S/c1-19(2)28(35)33-14-12-32(13-15-33)26(27(34)31-36)17-29-40(37,38)23-10-8-22(9-11-23)39-18-21-16-20(3)30-25-7-5-4-6-24(21)25/h4-11,16,19,26,29,36H,12-15,17-18H2,1-3H3,(H,31,34)/t26-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM235932
PNG
(US9365529, 20)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C32H34F3N5O5S/c1-22-18-24(28-4-2-3-5-29(28)37-22)21-45-26-10-12-27(13-11-26)46(43,44)36-19-30(31(41)38-42)40-16-14-39(15-17-40)20-23-6-8-25(9-7-23)32(33,34)35/h2-13,18,30,36,42H,14-17,19-21H2,1H3,(H,38,41)/t30-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM113588
PNG
(US8633196, 18 | US9365529, 18)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(Cc3ccc(F)cc3)CC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C31H34FN5O5S/c1-22-18-24(28-4-2-3-5-29(28)34-22)21-42-26-10-12-27(13-11-26)43(40,41)33-19-30(31(38)35-39)37-16-14-36(15-17-37)20-23-6-8-25(32)9-7-23/h2-13,18,30,33,39H,14-17,19-21H2,1H3,(H,35,38)/t30-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)


(Homo sapiens (Human))
BDBM113592
PNG
(US8633196, 24 | US9365529, 24)
Show SMILES CC(C)CS(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C28H37N5O7S2/c1-20(2)19-41(36,37)33-14-12-32(13-15-33)27(28(34)31-35)17-29-42(38,39)24-10-8-23(9-11-24)40-18-22-16-21(3)30-26-7-5-4-6-25(22)26/h4-11,16,20,27,29,35H,12-15,17-19H2,1-3H3,(H,31,34)/t27-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)


(Homo sapiens (Human))
BDBM113591
PNG
(US8633196, 23 | US9365529, 23)
Show SMILES CC(C)C(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C28H35N5O6S/c1-19(2)28(35)33-14-12-32(13-15-33)26(27(34)31-36)17-29-40(37,38)23-10-8-22(9-11-23)39-18-21-16-20(3)30-25-7-5-4-6-24(21)25/h4-11,16,19,26,29,36H,12-15,17-18H2,1-3H3,(H,31,34)/t26-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM113577
PNG
(US8633196, 14 | US8633196, 5 | US9365529, 5)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(CC2)S(C)(=O)=O)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C25H31N5O7S2/c1-18-15-19(22-5-3-4-6-23(22)27-18)17-37-20-7-9-21(10-8-20)39(35,36)26-16-24(25(31)28-32)29-11-13-30(14-12-29)38(2,33)34/h3-10,15,24,26,32H,11-14,16-17H2,1-2H3,(H,28,31)/t24-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)


(Homo sapiens (Human))
BDBM235932
PNG
(US9365529, 20)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C32H34F3N5O5S/c1-22-18-24(28-4-2-3-5-29(28)37-22)21-45-26-10-12-27(13-11-26)46(43,44)36-19-30(31(41)38-42)40-16-14-39(15-17-40)20-23-6-8-25(9-7-23)32(33,34)35/h2-13,18,30,36,42H,14-17,19-21H2,1H3,(H,38,41)/t30-/m0/s1
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GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM113593
PNG
(US8633196, 26 | US9365529, 26)
Show SMILES CC(C)S(=O)(=O)N1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C27H35N5O7S2/c1-19(2)41(37,38)32-14-12-31(13-15-32)26(27(33)30-34)17-28-40(35,36)23-10-8-22(9-11-23)39-18-21-16-20(3)29-25-7-5-4-6-24(21)25/h4-11,16,19,26,28,34H,12-15,17-18H2,1-3H3,(H,30,33)/t26-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM113577
PNG
(US8633196, 14 | US8633196, 5 | US9365529, 5)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(CC2)S(C)(=O)=O)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C25H31N5O7S2/c1-18-15-19(22-5-3-4-6-23(22)27-18)17-37-20-7-9-21(10-8-20)39(35,36)26-16-24(25(31)28-32)29-11-13-30(14-12-29)38(2,33)34/h3-10,15,24,26,32H,11-14,16-17H2,1-2H3,(H,28,31)/t24-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM113589
PNG
(US8633196, 19 | US9365529, 19)
Show SMILES CCN1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C26H33N5O5S/c1-3-30-12-14-31(15-13-30)25(26(32)29-33)17-27-37(34,35)22-10-8-21(9-11-22)36-18-20-16-19(2)28-24-7-5-4-6-23(20)24/h4-11,16,25,27,33H,3,12-15,17-18H2,1-2H3,(H,29,32)/t25-/m0/s1
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GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)


(Homo sapiens (Human))
BDBM113589
PNG
(US8633196, 19 | US9365529, 19)
Show SMILES CCN1CCN(CC1)[C@@H](CNS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO
Show InChI InChI=1S/C26H33N5O5S/c1-3-30-12-14-31(15-13-30)25(26(32)29-33)17-27-37(34,35)22-10-8-21(9-11-22)36-18-20-16-19(2)28-24-7-5-4-6-23(20)24/h4-11,16,25,27,33H,3,12-15,17-18H2,1-2H3,(H,29,32)/t25-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)


(Homo sapiens (Human))
BDBM113588
PNG
(US8633196, 18 | US9365529, 18)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(Cc3ccc(F)cc3)CC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C31H34FN5O5S/c1-22-18-24(28-4-2-3-5-29(28)34-22)21-42-26-10-12-27(13-11-26)43(40,41)33-19-30(31(38)35-39)37-16-14-36(15-17-37)20-23-6-8-25(32)9-7-23/h2-13,18,30,33,39H,14-17,19-21H2,1H3,(H,35,38)/t30-/m0/s1
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GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM113590
PNG
(US8633196, 21 | US9365529, 21)
Show SMILES Cc1ccc(CN2CCN(CC2)[C@@H](CNS(=O)(=O)c2ccc(OCc3cc(C)nc4ccccc34)cc2)C(=O)NO)cc1
Show InChI InChI=1S/C32H37N5O5S/c1-23-7-9-25(10-8-23)21-36-15-17-37(18-16-36)31(32(38)35-39)20-33-43(40,41)28-13-11-27(12-14-28)42-22-26-19-24(2)34-30-6-4-3-5-29(26)30/h3-14,19,31,33,39H,15-18,20-22H2,1-2H3,(H,35,38)/t31-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)


(Homo sapiens (Human))
BDBM235932
PNG
(US9365529, 20)
Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C32H34F3N5O5S/c1-22-18-24(28-4-2-3-5-29(28)37-22)21-45-26-10-12-27(13-11-26)46(43,44)36-19-30(31(41)38-42)40-16-14-39(15-17-40)20-23-6-8-25(9-7-23)32(33,34)35/h2-13,18,30,36,42H,14-17,19-21H2,1H3,(H,38,41)/t30-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVLOPMENT

US Patent


Assay Description
The molecules are dose-response tested on the following enzymes: MMP1, MMP3, MMP9, ADAM9 and ADAM10, according to the same protocol as that described...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%