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Patent code US9365562

Compile Data Set for Download or QSAR
Found 126 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236019
PNG
(US9365562, 57)
Show SMILES Cc1nc(Cc2cc(F)ccc2F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C26H24F2N8/c1-15-29-23(35-13-18(14-35)26-32-21-6-4-5-7-22(21)34(26)3)12-25(30-15)36-24(31-16(2)33-36)11-17-10-19(27)8-9-20(17)28/h4-10,12,18H,11,13-14H2,1-3H3
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US Patent
0.0650n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236020
PNG
(US9365562, 58)
Show SMILES Cc1nc(Cc2ccc(F)cc2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C26H25FN8/c1-16-28-23(34-14-19(15-34)26-31-21-6-4-5-7-22(21)33(26)3)13-25(29-16)35-24(30-17(2)32-35)12-18-8-10-20(27)11-9-18/h4-11,13,19H,12,14-15H2,1-3H3
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US Patent
0.120n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236035
PNG
(US9365562, 73)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2ccnn2C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C24H26N10O/c1-15-26-16(2)34(30-15)22-11-21(28-24(29-22)35-14-18-9-10-25-32(18)4)33-12-17(13-33)23-27-19-7-5-6-8-20(19)31(23)3/h5-11,17H,12-14H2,1-4H3
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0.130n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235985
PNG
(US9365562, 23)
Show SMILES CSc1nc(cc(n1)-n1nc(C)nc1C)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H22N8S/c1-12-21-13(2)28(25-12)18-9-17(23-20(24-18)29-4)27-10-14(11-27)19-22-15-7-5-6-8-16(15)26(19)3/h5-9,14H,10-11H2,1-4H3
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0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236018
PNG
(US9365562, 56)
Show SMILES Cc1nc(-c2c(F)cccc2F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C25H22F2N8/c1-14-28-21(34-12-16(13-34)24-31-19-9-4-5-10-20(19)33(24)3)11-22(29-14)35-25(30-15(2)32-35)23-17(26)7-6-8-18(23)27/h4-11,16H,12-13H2,1-3H3
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0.240n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236010
PNG
(US9365562, 48)
Show SMILES Cc1nc(CN2CCCC2=O)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C24H27N9O/c1-15-25-20(32-12-17(13-32)24-28-18-7-4-5-8-19(18)30(24)3)11-21(26-15)33-22(27-16(2)29-33)14-31-10-6-9-23(31)34/h4-5,7-8,11,17H,6,9-10,12-14H2,1-3H3
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0.260n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236039
PNG
(US9365562, 77)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)-n1ccnc1C)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H24N10/c1-14-25-16(3)33(29-14)21-11-20(27-23(28-21)32-10-9-24-15(32)2)31-12-17(13-31)22-26-18-7-5-6-8-19(18)30(22)4/h5-11,17H,12-13H2,1-4H3
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0.260n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236029
PNG
(US9365562, 67)
Show SMILES CCc1nc(C)nn1-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H21F3N8/c1-4-16-25-12(2)29-32(16)18-9-17(27-20(28-18)21(22,23)24)31-10-13(11-31)19-26-14-7-5-6-8-15(14)30(19)3/h5-9,13H,4,10-11H2,1-3H3
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0.280n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236034
PNG
(US9365562, 72)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2nccs2)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H23N9OS/c1-14-25-15(2)32(29-14)20-10-19(27-23(28-20)33-13-21-24-8-9-34-21)31-11-16(12-31)22-26-17-6-4-5-7-18(17)30(22)3/h4-10,16H,11-13H2,1-3H3
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0.280n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236041
PNG
(US9365562, 79)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)C#N)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H19N9/c1-12-22-13(2)29(26-12)19-8-18(24-17(9-21)25-19)28-10-14(11-28)20-23-15-6-4-5-7-16(15)27(20)3/h4-8,14H,10-11H2,1-3H3
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0.280n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236040
PNG
(US9365562, 78)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)N1CCCC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H27N9/c1-15-24-16(2)32(28-15)21-12-20(26-23(27-21)30-10-6-7-11-30)31-13-17(14-31)22-25-18-8-4-5-9-19(18)29(22)3/h4-5,8-9,12,17H,6-7,10-11,13-14H2,1-3H3
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0.290n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236012
PNG
(US9365562, 50)
Show SMILES Cc1nc(-c2ccccc2Cl)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C25H23ClN8/c1-15-27-22(33-13-17(14-33)24-30-20-10-6-7-11-21(20)32(24)3)12-23(28-15)34-25(29-16(2)31-34)18-8-4-5-9-19(18)26/h4-12,17H,13-14H2,1-3H3
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0.350n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236032
PNG
(US9365562, 70)
Show SMILES CC(C)Oc1nc(cc(n1)-n1nc(C)nc1C)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H26N8O/c1-13(2)31-22-25-19(10-20(26-22)30-15(4)23-14(3)27-30)29-11-16(12-29)21-24-17-8-6-7-9-18(17)28(21)5/h6-10,13,16H,11-12H2,1-5H3
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0.380n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236026
PNG
(US9365562, 64)
Show SMILES CCc1nc(C)nn1-c1cc(nc(OC)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H24N8O/c1-5-17-22-13(2)26-29(17)19-10-18(24-21(25-19)30-4)28-11-14(12-28)20-23-15-8-6-7-9-16(15)27(20)3/h6-10,14H,5,11-12H2,1-4H3
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0.400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236033
PNG
(US9365562, 71)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2ccno2)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H23N9O2/c1-14-25-15(2)32(29-14)21-10-20(27-23(28-21)33-13-17-8-9-24-34-17)31-11-16(12-31)22-26-18-6-4-5-7-19(18)30(22)3/h4-10,16H,11-13H2,1-3H3
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0.400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236000
PNG
(US9365562, 38)
Show SMILES CCCc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H26N8/c1-5-8-19-25-15(3)27-30(19)21-11-20(23-14(2)24-21)29-12-16(13-29)22-26-17-9-6-7-10-18(17)28(22)4/h6-7,9-11,16H,5,8,12-13H2,1-4H3
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0.410n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236023
PNG
(US9365562, 61)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H24N8/c1-13-23-14(2)30(27-13)20-10-19(25-21(26-20)15-8-9-15)29-11-16(12-29)22-24-17-6-4-5-7-18(17)28(22)3/h4-7,10,15-16H,8-9,11-12H2,1-3H3
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0.460n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236036
PNG
(US9365562, 74)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2ccon2)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H23N9O2/c1-14-24-15(2)32(28-14)21-10-20(26-23(27-21)33-13-17-8-9-34-29-17)31-11-16(12-31)22-25-18-6-4-5-7-19(18)30(22)3/h4-10,16H,11-13H2,1-3H3
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0.490n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236005
PNG
(US9365562, 43)
Show SMILES COC(=O)CCc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H26N8O2/c1-14-24-20(11-21(25-14)31-19(26-15(2)28-31)9-10-22(32)33-4)30-12-16(13-30)23-27-17-7-5-6-8-18(17)29(23)3/h5-8,11,16H,9-10,12-13H2,1-4H3
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0.490n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235968
PNG
(US9365562, 6)
Show SMILES Cc1cnn(c1)-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H23N7/c1-14-10-23-29(11-14)20-9-19(25-21(26-20)15-7-8-15)28-12-16(13-28)22-24-17-5-3-4-6-18(17)27(22)2/h3-6,9-11,15-16H,7-8,12-13H2,1-2H3
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0.530n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235995
PNG
(US9365562, 33)
Show SMILES Cc1cnn(n1)-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H22N8/c1-13-10-22-29(26-13)19-9-18(24-20(25-19)14-7-8-14)28-11-15(12-28)21-23-16-5-3-4-6-17(16)27(21)2/h3-6,9-10,14-15H,7-8,11-12H2,1-2H3
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0.540n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236038
PNG
(US9365562, 76)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)-n1cccn1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H22N10/c1-14-24-15(2)32(28-14)20-11-19(26-22(27-20)31-10-6-9-23-31)30-12-16(13-30)21-25-17-7-4-5-8-18(17)29(21)3/h4-11,16H,12-13H2,1-3H3
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0.610n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235964
PNG
(US9365562, 2)
Show SMILES Cc1cnn(c1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H21N7/c1-13-9-21-27(10-13)19-8-18(22-14(2)23-19)26-11-15(12-26)20-24-16-6-4-5-7-17(16)25(20)3/h4-10,15H,11-12H2,1-3H3
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0.610n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235970
PNG
(US9365562, 8)
Show SMILES Cc1cn(nc1C)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H23N7/c1-13-10-28(25-14(13)2)20-9-19(22-15(3)23-20)27-11-16(12-27)21-24-17-7-5-6-8-18(17)26(21)4/h5-10,16H,11-12H2,1-4H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235976
PNG
(US9365562, 14)
Show SMILES CC(C)c1ccn(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H25N7/c1-14(2)17-9-10-29(26-17)21-11-20(23-15(3)24-21)28-12-16(13-28)22-25-18-7-5-6-8-19(18)27(22)4/h5-11,14,16H,12-13H2,1-4H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236037
PNG
(US9365562, 75)
Show SMILES Cc1noc(COc2nc(cc(n2)-n2nc(C)nc2C)N2CC(C2)c2nc3ccccc3n2C)n1
Show InChI InChI=1S/C23H24N10O2/c1-13-24-15(3)33(29-13)20-9-19(27-23(28-20)34-12-21-25-14(2)30-35-21)32-10-16(11-32)22-26-17-7-5-6-8-18(17)31(22)4/h5-9,16H,10-12H2,1-4H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235975
PNG
(US9365562, 13)
Show SMILES Cc1nc(cc(n1)-n1ccc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H23N7/c1-14-23-20(11-21(24-14)29-10-9-17(26-29)15-7-8-15)28-12-16(13-28)22-25-18-5-3-4-6-19(18)27(22)2/h3-6,9-11,15-16H,7-8,12-13H2,1-2H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236024
PNG
(US9365562, 62)
Show SMILES COc1nc(cc(n1)-n1nc(C)nc1C)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H22N8O/c1-12-21-13(2)28(25-12)18-9-17(23-20(24-18)29-4)27-10-14(11-27)19-22-15-7-5-6-8-16(15)26(19)3/h5-9,14H,10-11H2,1-4H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235973
PNG
(US9365562, 11)
Show SMILES Cc1nc(cc(n1)-n1ccc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H18F3N7/c1-12-24-17(9-18(25-12)30-8-7-16(27-30)20(21,22)23)29-10-13(11-29)19-26-14-5-3-4-6-15(14)28(19)2/h3-9,13H,10-11H2,1-2H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235997
PNG
(US9365562, 35)
Show SMILES CCc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H24N8/c1-5-18-24-14(3)26-29(18)20-10-19(22-13(2)23-20)28-11-15(12-28)21-25-16-8-6-7-9-17(16)27(21)4/h6-10,15H,5,11-12H2,1-4H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235966
PNG
(US9365562, 4)
Show SMILES COc1nc(cc(n1)-n1cc(C)cn1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H21N7O/c1-13-9-21-27(10-13)18-8-17(23-20(24-18)28-3)26-11-14(12-26)19-22-15-6-4-5-7-16(15)25(19)2/h4-10,14H,11-12H2,1-3H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236059
PNG
(US9365562, 97)
Show SMILES Cc1ccc(nc1)-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H19F3N6/c1-13-7-8-15(26-10-13)17-9-19(29-21(28-17)22(23,24)25)31-11-14(12-31)20-27-16-5-3-4-6-18(16)30(20)2/h3-10,14H,11-12H2,1-2H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235971
PNG
(US9365562, 9)
Show SMILES Cc1nn(c(C)c1C)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H25N7/c1-13-14(2)26-29(15(13)3)21-10-20(23-16(4)24-21)28-11-17(12-28)22-25-18-8-6-7-9-19(18)27(22)5/h6-10,17H,11-12H2,1-5H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236028
PNG
(US9365562, 66)
Show SMILES COCc1nc(C)nn1-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H21F3N8O/c1-12-25-18(11-33-3)32(29-12)17-8-16(27-20(28-17)21(22,23)24)31-9-13(10-31)19-26-14-6-4-5-7-15(14)30(19)2/h4-8,13H,9-11H2,1-3H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236003
PNG
(US9365562, 41)
Show SMILES C[C@@H](O)Cc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H26N8O/c1-13(31)9-20-25-15(3)27-30(20)21-10-19(23-14(2)24-21)29-11-16(12-29)22-26-17-7-5-6-8-18(17)28(22)4/h5-8,10,13,16,31H,9,11-12H2,1-4H3/t13-/m1/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236056
PNG
(US9365562, 94)
Show SMILES Cc1ccc(nc1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H22N6/c1-14-8-9-17(23-11-14)19-10-21(25-15(2)24-19)28-12-16(13-28)22-26-18-6-4-5-7-20(18)27(22)3/h4-11,16H,12-13H2,1-3H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236022
PNG
(US9365562, 60)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H19F3N8/c1-11-24-12(2)31(28-11)17-8-16(26-19(27-17)20(21,22)23)30-9-13(10-30)18-25-14-6-4-5-7-15(14)29(18)3/h4-8,13H,9-10H2,1-3H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235994
PNG
(US9365562, 32)
Show SMILES Cc1cn(nn1)-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H22N8/c1-13-10-29(26-25-13)19-9-18(23-20(24-19)14-7-8-14)28-11-15(12-28)21-22-16-5-3-4-6-17(16)27(21)2/h3-6,9-10,14-15H,7-8,11-12H2,1-2H3
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Merck Sharp & Dohme Corp.

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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236061
PNG
(US9365562, 99)
Show SMILES Cc1nc(cc(n1)-c1ccc(Cl)cn1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H19ClN6/c1-13-24-18(16-8-7-15(22)10-23-16)9-20(25-13)28-11-14(12-28)21-26-17-5-3-4-6-19(17)27(21)2/h3-10,14H,11-12H2,1-2H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236013
PNG
(US9365562, 51)
Show SMILES Cc1nc(-c2ccccc2F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C25H23FN8/c1-15-27-22(33-13-17(14-33)24-30-20-10-6-7-11-21(20)32(24)3)12-23(28-15)34-25(29-16(2)31-34)18-8-4-5-9-19(18)26/h4-12,17H,13-14H2,1-3H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235967
PNG
(US9365562, 5)
Show SMILES Cc1cnn(c1)-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H18F3N7/c1-12-8-24-30(9-12)17-7-16(26-19(27-17)20(21,22)23)29-10-13(11-29)18-25-14-5-3-4-6-15(14)28(18)2/h3-9,13H,10-11H2,1-2H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236008
PNG
(US9365562, 46)
Show SMILES Cc1nc(COc2ccccc2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C26H26N8O/c1-17-27-23(33-14-19(15-33)26-30-21-11-7-8-12-22(21)32(26)3)13-24(28-17)34-25(29-18(2)31-34)16-35-20-9-5-4-6-10-20/h4-13,19H,14-16H2,1-3H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235993
PNG
(US9365562, 31)
Show SMILES Cc1cnn(n1)-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C19H17F3N8/c1-11-8-23-30(27-11)16-7-15(25-18(26-16)19(20,21)22)29-9-12(10-29)17-24-13-5-3-4-6-14(13)28(17)2/h3-8,12H,9-10H2,1-2H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236049
PNG
(US9365562, 87)
Show SMILES Cc1nc(cc(n1)-c1cccc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H19F3N6/c1-13-26-17(15-7-5-9-19(28-15)22(23,24)25)10-20(27-13)31-11-14(12-31)21-29-16-6-3-4-8-18(16)30(21)2/h3-10,14H,11-12H2,1-2H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235987
PNG
(US9365562, 25)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(CC#N)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H21N9/c1-13-23-14(2)30(27-13)20-10-19(25-18(26-20)8-9-22)29-11-15(12-29)21-24-16-6-4-5-7-17(16)28(21)3/h4-7,10,15H,8,11-12H2,1-3H3
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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236058
PNG
(US9365562, 96)
Show SMILES COc1nc(cc(n1)-c1ccc(C)cn1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H22N6O/c1-14-8-9-16(23-11-14)18-10-20(26-22(25-18)29-3)28-12-15(13-28)21-24-17-6-4-5-7-19(17)27(21)2/h4-11,15H,12-13H2,1-3H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235996
PNG
(US9365562, 34)
Show SMILES COc1nc(cc(n1)-n1ncc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C19H20N8O/c1-12-9-20-27(24-12)17-8-16(22-19(23-17)28-3)26-10-13(11-26)18-21-14-6-4-5-7-15(14)25(18)2/h4-9,13H,10-11H2,1-3H3
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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236030
PNG
(US9365562, 68)
Show SMILES Cc1nc(C2CC2)n(n1)-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H21F3N8/c1-12-26-20(13-7-8-13)33(30-12)18-9-17(28-21(29-18)22(23,24)25)32-10-14(11-32)19-27-15-5-3-4-6-16(15)31(19)2/h3-6,9,13-14H,7-8,10-11H2,1-2H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236021
PNG
(US9365562, 59)
Show SMILES COCc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H24N8O/c1-13-22-18(9-19(23-13)29-20(12-30-4)24-14(2)26-29)28-10-15(11-28)21-25-16-7-5-6-8-17(16)27(21)3/h5-9,15H,10-12H2,1-4H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235990
PNG
(US9365562, 28)
Show SMILES Cc1cnn(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C19H20N8/c1-12-9-20-27(24-12)18-8-17(21-13(2)22-18)26-10-14(11-26)19-23-15-6-4-5-7-16(15)25(19)3/h4-9,14H,10-11H2,1-3H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235986
PNG
(US9365562, 24)
Show SMILES COC(=O)c1nc(cc(n1)-n1nc(C)nc1C)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H22N8O2/c1-12-22-13(2)29(26-12)18-9-17(24-19(25-18)21(30)31-4)28-10-14(11-28)20-23-15-7-5-6-8-16(15)27(20)3/h5-9,14H,10-11H2,1-4H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236031
PNG
(US9365562, 69)
Show SMILES Cc1nc(C2CCOCC2)n(n1)-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C24H25F3N8O/c1-14-28-22(15-7-9-36-10-8-15)35(32-14)20-11-19(30-23(31-20)24(25,26)27)34-12-16(13-34)21-29-17-5-3-4-6-18(17)33(21)2/h3-6,11,15-16H,7-10,12-13H2,1-2H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236025
PNG
(US9365562, 63)
Show SMILES COc1nc(cc(n1)-n1nc(C)nc1C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H24N8O/c1-13-23-21(14-8-9-14)30(27-13)19-10-18(25-22(26-19)31-3)29-11-15(12-29)20-24-16-6-4-5-7-17(16)28(20)2/h4-7,10,14-15H,8-9,11-12H2,1-3H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236057
PNG
(US9365562, 95)
Show SMILES Cc1nc(cc(n1)-c1ccccn1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H20N6/c1-14-23-18(16-7-5-6-10-22-16)11-20(24-14)27-12-15(13-27)21-25-17-8-3-4-9-19(17)26(21)2/h3-11,15H,12-13H2,1-2H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236004
PNG
(US9365562, 42)
Show SMILES COCCc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H26N8O/c1-14-23-20(11-21(24-14)30-19(9-10-31-4)25-15(2)27-30)29-12-16(13-29)22-26-17-7-5-6-8-18(17)28(22)3/h5-8,11,16H,9-10,12-13H2,1-4H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236002
PNG
(US9365562, 40)
Show SMILES C[C@H](O)Cc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H26N8O/c1-13(31)9-20-25-15(3)27-30(20)21-10-19(23-14(2)24-21)29-11-16(12-29)22-26-17-7-5-6-8-18(17)28(22)4/h5-8,10,13,16,31H,9,11-12H2,1-4H3/t13-/m0/s1
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236007
PNG
(US9365562, 45)
Show SMILES Cc1nc(C2CCCCC2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C25H30N8/c1-16-26-22(32-14-19(15-32)24-29-20-11-7-8-12-21(20)31(24)3)13-23(27-16)33-25(28-17(2)30-33)18-9-5-4-6-10-18/h7-8,11-13,18-19H,4-6,9-10,14-15H2,1-3H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235963
PNG
(US9365562, 1)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H22N8/c1-12-22-18(9-19(23-12)28-14(3)21-13(2)25-28)27-10-15(11-27)20-24-16-7-5-6-8-17(16)26(20)4/h5-9,15H,10-11H2,1-4H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235999
PNG
(US9365562, 37)
Show SMILES Cc1nc(C2CCOCC2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C24H28N8O/c1-15-25-21(31-13-18(14-31)23-28-19-6-4-5-7-20(19)30(23)3)12-22(26-15)32-24(27-16(2)29-32)17-8-10-33-11-9-17/h4-7,12,17-18H,8-11,13-14H2,1-3H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236067
PNG
(US9365562, 105)
Show SMILES Cc1nc(cc(n1)-c1nccs1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C19H18N6S/c1-12-21-15(19-20-7-8-26-19)9-17(22-12)25-10-13(11-25)18-23-14-5-3-4-6-16(14)24(18)2/h3-9,13H,10-11H2,1-2H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236065
PNG
(US9365562, 103)
Show SMILES Cc1nc(cc(n1)-c1ccc(cn1)C#N)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H19N7/c1-14-25-19(17-8-7-15(10-23)11-24-17)9-21(26-14)29-12-16(13-29)22-27-18-5-3-4-6-20(18)28(22)2/h3-9,11,16H,12-13H2,1-2H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235965
PNG
(US9365562, 3)
Show SMILES Cc1nc(cc(n1)-n1cccn1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C19H19N7/c1-13-21-17(10-18(22-13)26-9-5-8-20-26)25-11-14(12-25)19-23-15-6-3-4-7-16(15)24(19)2/h3-10,14H,11-12H2,1-2H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236027
PNG
(US9365562, 65)
Show SMILES COCc1nc(C)nn1-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H26N8O/c1-14-24-21(13-32-3)31(28-14)20-10-19(26-22(27-20)15-8-9-15)30-11-16(12-30)23-25-17-6-4-5-7-18(17)29(23)2/h4-7,10,15-16H,8-9,11-13H2,1-3H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236006
PNG
(US9365562, 44)
Show SMILES CCOC(=O)Cc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H26N8O2/c1-5-33-22(32)11-21-26-15(3)28-31(21)20-10-19(24-14(2)25-20)30-12-16(13-30)23-27-17-8-6-7-9-18(17)29(23)4/h6-10,16H,5,11-13H2,1-4H3
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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235978
PNG
(US9365562, 16)
Show SMILES Cc1nc(cc(n1)-n1cc(cn1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H18F3N7/c1-12-25-17(7-18(26-12)30-11-14(8-24-30)20(21,22)23)29-9-13(10-29)19-27-15-5-3-4-6-16(15)28(19)2/h3-8,11,13H,9-10H2,1-2H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236001
PNG
(US9365562, 39)
Show SMILES CC(C)c1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H26N8/c1-13(2)21-25-15(4)27-30(21)20-10-19(23-14(3)24-20)29-11-16(12-29)22-26-17-8-6-7-9-18(17)28(22)5/h6-10,13,16H,11-12H2,1-5H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235988
PNG
(US9365562, 26)
Show SMILES CCOC(=O)Cc1nc(cc(n1)-n1nc(C)nc1C)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H26N8O2/c1-5-33-22(32)10-19-26-20(11-21(27-19)31-15(3)24-14(2)28-31)30-12-16(13-30)23-25-17-8-6-7-9-18(17)29(23)4/h6-9,11,16H,5,10,12-13H2,1-4H3
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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235991
PNG
(US9365562, 29)
Show SMILES Cc1cn(nn1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C19H20N8/c1-12-9-27(24-23-12)18-8-17(20-13(2)21-18)26-10-14(11-26)19-22-15-6-4-5-7-16(15)25(19)3/h4-9,14H,10-11H2,1-3H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235980
PNG
(US9365562, 18)
Show SMILES COc1cnn(c1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H21N7O/c1-13-22-18(8-19(23-13)27-12-15(28-3)9-21-27)26-10-14(11-26)20-24-16-6-4-5-7-17(16)25(20)2/h4-9,12,14H,10-11H2,1-3H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235984
PNG
(US9365562, 22)
Show SMILES CCc1nc(CC)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H26N8/c1-5-18-26-19(6-2)30(27-18)21-11-20(23-14(3)24-21)29-12-15(13-29)22-25-16-9-7-8-10-17(16)28(22)4/h7-11,15H,5-6,12-13H2,1-4H3
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The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235977
PNG
(US9365562, 15)
Show SMILES CCc1cnn(c1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H23N7/c1-4-15-10-22-28(11-15)20-9-19(23-14(2)24-20)27-12-16(13-27)21-25-17-7-5-6-8-18(17)26(21)3/h5-11,16H,4,12-13H2,1-3H3
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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236009
PNG
(US9365562, 47)
Show SMILES CN1CC(CC1=O)c1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C24H27N9O/c1-14-25-20(32-12-17(13-32)23-28-18-7-5-6-8-19(18)31(23)4)10-21(26-14)33-24(27-15(2)29-33)16-9-22(34)30(3)11-16/h5-8,10,16-17H,9,11-13H2,1-4H3
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3.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235972
PNG
(US9365562, 10)
Show SMILES Cc1cc(n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C)C(F)(F)F
Show InChI InChI=1S/C21H20F3N7/c1-12-8-17(21(22,23)24)31(28-12)19-9-18(25-13(2)26-19)30-10-14(11-30)20-27-15-6-4-5-7-16(15)29(20)3/h4-9,14H,10-11H2,1-3H3
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4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235979
PNG
(US9365562, 17)
Show SMILES Cc1nc(cc(n1)-n1cc(cn1)C#N)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H18N8/c1-13-23-18(7-19(24-13)28-10-14(8-21)9-22-28)27-11-15(12-27)20-25-16-5-3-4-6-17(16)26(20)2/h3-7,9-10,15H,11-12H2,1-2H3
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4.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235998
PNG
(US9365562, 36)
Show SMILES Cc1nc(C2CC2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H24N8/c1-13-23-19(10-20(24-13)30-22(15-8-9-15)25-14(2)27-30)29-11-16(12-29)21-26-17-6-4-5-7-18(17)28(21)3/h4-7,10,15-16H,8-9,11-12H2,1-3H3
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4.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235974
PNG
(US9365562, 12)
Show SMILES COc1ccn(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H21N7O/c1-13-21-17(10-18(22-13)27-9-8-19(24-27)28-3)26-11-14(12-26)20-23-15-6-4-5-7-16(15)25(20)2/h4-10,14H,11-12H2,1-3H3
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4.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236081
PNG
(US9365562, 119)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1CCC#N
Show InChI InChI=1S/C22H23N9/c1-14-25-20(11-21(26-14)31-16(3)24-15(2)28-31)29-12-17(13-29)22-27-18-7-4-5-8-19(18)30(22)10-6-9-23/h4-5,7-8,11,17H,6,10,12-13H2,1-3H3
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5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236060
PNG
(US9365562, 98)
Show SMILES Cc1cccc(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H22N6/c1-14-7-6-9-17(23-14)19-11-21(25-15(2)24-19)28-12-16(13-28)22-26-18-8-4-5-10-20(18)27(22)3/h4-11,16H,12-13H2,1-3H3
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5.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235992
PNG
(US9365562, 30)
Show SMILES Cc1cn(nn1)-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C19H17F3N8/c1-11-8-30(27-26-11)16-7-15(24-18(25-16)19(20,21)22)29-9-12(10-29)17-23-13-5-3-4-6-14(13)28(17)2/h3-8,12H,9-10H2,1-2H3
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5.60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236069
PNG
(US9365562, 107)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C19H20N8/c1-11-21-17(8-18(22-11)27-13(3)20-12(2)25-27)26-9-14(10-26)19-23-15-6-4-5-7-16(15)24-19/h4-8,14H,9-10H2,1-3H3,(H,23,24)
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5.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236076
PNG
(US9365562, 114)
Show SMILES CCn1c(nc2ccccc12)C1CN(C1)c1cc(nc(C)n1)-n1nc(C)nc1C
Show InChI InChI=1S/C21H24N8/c1-5-28-18-9-7-6-8-17(18)25-21(28)16-11-27(12-16)19-10-20(24-13(2)23-19)29-15(4)22-14(3)26-29/h6-10,16H,5,11-12H2,1-4H3
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5.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236078
PNG
(US9365562, 116)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1CCF
Show InChI InChI=1S/C21H23FN8/c1-13-24-19(10-20(25-13)30-15(3)23-14(2)27-30)28-11-16(12-28)21-26-17-6-4-5-7-18(17)29(21)9-8-22/h4-7,10,16H,8-9,11-12H2,1-3H3
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6.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236079
PNG
(US9365562, 117)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1CCO
Show InChI InChI=1S/C21H24N8O/c1-13-23-19(10-20(24-13)29-15(3)22-14(2)26-29)27-11-16(12-27)21-25-17-6-4-5-7-18(17)28(21)8-9-30/h4-7,10,16,30H,8-9,11-12H2,1-3H3
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6.60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236011
PNG
(US9365562, 49)
Show SMILES Cc1nc(-c2ccccc2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C25H24N8/c1-16-26-22(32-14-19(15-32)24-29-20-11-7-8-12-21(20)31(24)3)13-23(27-16)33-25(28-17(2)30-33)18-9-5-4-6-10-18/h4-13,19H,14-15H2,1-3H3
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6.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235983
PNG
(US9365562, 21)
Show SMILES Cc1nc(nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C)C(F)(F)F
Show InChI InChI=1S/C20H19F3N8/c1-11-24-16(8-17(25-11)31-12(2)26-19(28-31)20(21,22)23)30-9-13(10-30)18-27-14-6-4-5-7-15(14)29(18)3/h4-8,13H,9-10H2,1-3H3
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7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236085
PNG
(US9365562, 123)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2cccc(F)c2n1C
Show InChI InChI=1S/C20H21FN8/c1-11-23-17(8-18(24-11)29-13(3)22-12(2)26-29)28-9-14(10-28)20-25-16-7-5-6-15(21)19(16)27(20)4/h5-8,14H,9-10H2,1-4H3
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7.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236014
PNG
(US9365562, 52)
Show SMILES Cc1nc(-c2cccnc2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C24H23N9/c1-15-26-21(32-13-18(14-32)23-29-19-8-4-5-9-20(19)31(23)3)11-22(27-15)33-24(28-16(2)30-33)17-7-6-10-25-12-17/h4-12,18H,13-14H2,1-3H3
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7.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236071
PNG
(US9365562, 109)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccc(F)cc2[nH]1
Show InChI InChI=1S/C19H19FN8/c1-10-22-17(7-18(23-10)28-12(3)21-11(2)26-28)27-8-13(9-27)19-24-15-5-4-14(20)6-16(15)25-19/h4-7,13H,8-9H2,1-3H3,(H,24,25)
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8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236047
PNG
(US9365562, 85)
Show SMILES Cc1ccc(c(F)n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H21FN6/c1-13-8-9-16(21(23)24-13)18-10-20(26-14(2)25-18)29-11-15(12-29)22-27-17-6-4-5-7-19(17)28(22)3/h4-10,15H,11-12H2,1-3H3
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8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235981
PNG
(US9365562, 19)
Show SMILES Cc1nc(cc(n1)-n1cc(CO)cn1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H21N7O/c1-13-22-18(7-19(23-13)27-9-14(12-28)8-21-27)26-10-15(11-26)20-24-16-5-3-4-6-17(16)25(20)2/h3-9,15,28H,10-12H2,1-2H3
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8.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235989
PNG
(US9365562, 27)
Show SMILES Cc1cnnn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C19H20N8/c1-12-9-20-24-27(12)18-8-17(21-13(2)22-18)26-10-14(11-26)19-23-15-6-4-5-7-16(15)25(19)3/h4-9,14H,10-11H2,1-3H3
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8.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236082
PNG
(US9365562, 120)
Show SMILES CCOCCn1c(nc2ccccc12)C1CN(C1)c1cc(nc(C)n1)-n1nc(C)nc1C
Show InChI InChI=1S/C23H28N8O/c1-5-32-11-10-30-20-9-7-6-8-19(20)27-23(30)18-13-29(14-18)21-12-22(26-15(2)25-21)31-17(4)24-16(3)28-31/h6-9,12,18H,5,10-11,13-14H2,1-4H3
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8.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235969
PNG
(US9365562, 7)
Show SMILES Cc1cc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H23N7/c1-13-9-14(2)28(25-13)20-10-19(22-15(3)23-20)27-11-16(12-27)21-24-17-7-5-6-8-18(17)26(21)4/h5-10,16H,11-12H2,1-4H3
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8.60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236064
PNG
(US9365562, 102)
Show SMILES CC(=O)c1ccc(nc1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H22N6O/c1-14(30)16-8-9-18(24-11-16)20-10-22(26-15(2)25-20)29-12-17(13-29)23-27-19-6-4-5-7-21(19)28(23)3/h4-11,17H,12-13H2,1-3H3
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9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236083
PNG
(US9365562, 121)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1CCCC#N
Show InChI InChI=1S/C23H25N9/c1-15-26-21(12-22(27-15)32-17(3)25-16(2)29-32)30-13-18(14-30)23-28-19-8-4-5-9-20(19)31(23)11-7-6-10-24/h4-5,8-9,12,18H,6-7,11,13-14H2,1-3H3
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9.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236017
PNG
(US9365562, 55)
Show SMILES Cc1nc(-c2ccc(C)nc2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C25H25N9/c1-15-9-10-18(12-26-15)25-29-17(3)31-34(25)23-11-22(27-16(2)28-23)33-13-19(14-33)24-30-20-7-5-6-8-21(20)32(24)4/h5-12,19H,13-14H2,1-4H3
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10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236068
PNG
(US9365562, 106)
Show SMILES Cc1nc(cc(n1)-c1cccnn1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H19N7/c1-13-22-17(15-7-5-9-21-25-15)10-19(23-13)27-11-14(12-27)20-24-16-6-3-4-8-18(16)26(20)2/h3-10,14H,11-12H2,1-2H3
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11n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236080
PNG
(US9365562, 118)
Show SMILES CCCn1c(nc2ccccc12)C1CN(C1)c1cc(nc(C)n1)-n1nc(C)nc1C
Show InChI InChI=1S/C22H26N8/c1-5-10-29-19-9-7-6-8-18(19)26-22(29)17-12-28(13-17)20-11-21(25-14(2)24-20)30-16(4)23-15(3)27-30/h6-9,11,17H,5,10,12-13H2,1-4H3
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13n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236077
PNG
(US9365562, 115)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1CC#N
Show InChI InChI=1S/C21H21N9/c1-13-24-19(10-20(25-13)30-15(3)23-14(2)27-30)28-11-16(12-28)21-26-17-6-4-5-7-18(17)29(21)9-8-22/h4-7,10,16H,9,11-12H2,1-3H3
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14n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236052
PNG
(US9365562, 90)
Show SMILES Cc1nc(cc(n1)-c1ccccc1F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H20FN5/c1-14-24-19(16-7-3-4-8-17(16)23)11-21(25-14)28-12-15(13-28)22-26-18-9-5-6-10-20(18)27(22)2/h3-11,15H,12-13H2,1-2H3
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15n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236016
PNG
(US9365562, 54)
Show SMILES Cc1nc(-c2ccc(cc2)C#N)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C26H23N9/c1-16-28-23(34-14-20(15-34)25-31-21-6-4-5-7-22(21)33(25)3)12-24(29-16)35-26(30-17(2)32-35)19-10-8-18(13-27)9-11-19/h4-12,20H,14-15H2,1-3H3
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16n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236084
PNG
(US9365562, 122)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2c(F)cccc2n1C
Show InChI InChI=1S/C20H21FN8/c1-11-23-17(8-18(24-11)29-13(3)22-12(2)26-29)28-9-14(10-28)20-25-19-15(21)6-5-7-16(19)27(20)4/h5-8,14H,9-10H2,1-4H3
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17n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236072
PNG
(US9365562, 110)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2cccc(C)c2[nH]1
Show InChI InChI=1S/C20H22N8/c1-11-6-5-7-16-19(11)25-20(24-16)15-9-27(10-15)17-8-18(23-12(2)22-17)28-14(4)21-13(3)26-28/h5-8,15H,9-10H2,1-4H3,(H,24,25)
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17n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236055
PNG
(US9365562, 93)
Show SMILES Cc1nc(cc(n1)-c1ccccc1C(O)=O)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H21N5O2/c1-14-24-19(16-7-3-4-8-17(16)23(29)30)11-21(25-14)28-12-15(13-28)22-26-18-9-5-6-10-20(18)27(22)2/h3-11,15H,12-13H2,1-2H3,(H,29,30)
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19n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236070
PNG
(US9365562, 108)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2cccc(F)c2[nH]1
Show InChI InChI=1S/C19H19FN8/c1-10-22-16(7-17(23-10)28-12(3)21-11(2)26-28)27-8-13(9-27)19-24-15-6-4-5-14(20)18(15)25-19/h4-7,13H,8-9H2,1-3H3,(H,24,25)
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19n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236066
PNG
(US9365562, 104)
Show SMILES Cc1nc(cc(n1)-c1ncco1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C19H18N6O/c1-12-21-15(19-20-7-8-26-19)9-17(22-12)25-10-13(11-25)18-23-14-5-3-4-6-16(14)24(18)2/h3-9,13H,10-11H2,1-2H3
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20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236053
PNG
(US9365562, 91)
Show SMILES Cc1nc(cc(n1)-c1ccccc1OC(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H21F2N5O/c1-14-26-18(16-7-3-6-10-20(16)31-23(24)25)11-21(27-14)30-12-15(13-30)22-28-17-8-4-5-9-19(17)29(22)2/h3-11,15,23H,12-13H2,1-2H3
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22n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236086
PNG
(US9365562, 124)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2c(C)cccc2n1C
Show InChI InChI=1S/C21H24N8/c1-12-7-6-8-17-20(12)25-21(27(17)5)16-10-28(11-16)18-9-19(24-13(2)23-18)29-15(4)22-14(3)26-29/h6-9,16H,10-11H2,1-5H3
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22n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236015
PNG
(US9365562, 53)
Show SMILES Cc1nc(-c2cnc(C)cn2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C24H24N10/c1-14-10-26-19(11-25-14)24-29-16(3)31-34(24)22-9-21(27-15(2)28-22)33-12-17(13-33)23-30-18-7-5-6-8-20(18)32(23)4/h5-11,17H,12-13H2,1-4H3
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26n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236046
PNG
(US9365562, 84)
Show SMILES COc1nc(C)ccc1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H24N6O/c1-14-9-10-17(23(24-14)30-4)19-11-21(26-15(2)25-19)29-12-16(13-29)22-27-18-7-5-6-8-20(18)28(22)3/h5-11,16H,12-13H2,1-4H3
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27n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236044
PNG
(US9365562, 82)
Show SMILES COc1ncccc1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H22N6O/c1-14-24-18(16-7-6-10-23-22(16)29-3)11-20(25-14)28-12-15(13-28)21-26-17-8-4-5-9-19(17)27(21)2/h4-11,15H,12-13H2,1-3H3
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27n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236054
PNG
(US9365562, 92)
Show SMILES Cc1nc(cc(n1)-c1ccccc1O)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H21N5O/c1-14-23-18(16-7-3-6-10-20(16)28)11-21(24-14)27-12-15(13-27)22-25-17-8-4-5-9-19(17)26(22)2/h3-11,15,28H,12-13H2,1-2H3
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30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236063
PNG
(US9365562, 101)
Show SMILES CC(=O)c1ccnc(c1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H22N6O/c1-14(30)16-8-9-24-19(10-16)20-11-22(26-15(2)25-20)29-12-17(13-29)23-27-18-6-4-5-7-21(18)28(23)3/h4-11,17H,12-13H2,1-3H3
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31n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236087
PNG
(US9365562, 125)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2c(cccc2n1C)C(F)(F)F
Show InChI InChI=1S/C21H21F3N8/c1-11-26-17(8-18(27-11)32-13(3)25-12(2)29-32)31-9-14(10-31)20-28-19-15(21(22,23)24)6-5-7-16(19)30(20)4/h5-8,14H,9-10H2,1-4H3
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37n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235982
PNG
(US9365562, 20)
Show SMILES COc1nc(cc(n1)-n1cc(cn1)C(C)O)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H23N7O2/c1-13(29)14-9-22-28(12-14)19-8-18(24-21(25-19)30-3)27-10-15(11-27)20-23-16-6-4-5-7-17(16)26(20)2/h4-9,12-13,15,29H,10-11H2,1-3H3
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37n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236073
PNG
(US9365562, 111)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccc(C)cc2[nH]1
Show InChI InChI=1S/C20H22N8/c1-11-5-6-16-17(7-11)25-20(24-16)15-9-27(10-15)18-8-19(23-12(2)22-18)28-14(4)21-13(3)26-28/h5-8,15H,9-10H2,1-4H3,(H,24,25)
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39n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236062
PNG
(US9365562, 100)
Show SMILES COc1cccnc1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H22N6O/c1-14-24-17(21-19(29-3)9-6-10-23-21)11-20(25-14)28-12-15(13-28)22-26-16-7-4-5-8-18(16)27(22)2/h4-11,15H,12-13H2,1-3H3
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41n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236048
PNG
(US9365562, 86)
Show SMILES Cc1nc(cc(n1)-c1ccncc1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H20N6/c1-14-23-18(15-7-9-22-10-8-15)11-20(24-14)27-12-16(13-27)21-25-17-5-3-4-6-19(17)26(21)2/h3-11,16H,12-13H2,1-2H3
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46n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236051
PNG
(US9365562, 89)
Show SMILES COc1ccccc1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H23N5O/c1-15-24-19(17-8-4-7-11-21(17)29-3)12-22(25-15)28-13-16(14-28)23-26-18-9-5-6-10-20(18)27(23)2/h4-12,16H,13-14H2,1-3H3
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63n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236050
PNG
(US9365562, 88)
Show SMILES Cc1nc(cc(n1)-c1ccccc1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H21N5/c1-15-23-19(16-8-4-3-5-9-16)12-21(24-15)27-13-17(14-27)22-25-18-10-6-7-11-20(18)26(22)2/h3-12,17H,13-14H2,1-2H3
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63n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236075
PNG
(US9365562, 113)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccc(cc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N8/c1-10-25-17(7-18(26-10)31-12(3)24-11(2)29-31)30-8-13(9-30)19-27-15-5-4-14(20(21,22)23)6-16(15)28-19/h4-7,13H,8-9H2,1-3H3,(H,27,28)
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>75n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


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Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236074
PNG
(US9365562, 112)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2cccc(c2[nH]1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N8/c1-10-25-16(7-17(26-10)31-12(3)24-11(2)29-31)30-8-13(9-30)19-27-15-6-4-5-14(18(15)28-19)20(21,22)23/h4-7,13H,8-9H2,1-3H3,(H,27,28)
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>75n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236045
PNG
(US9365562, 83)
Show SMILES CC(=O)Nc1ncccc1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H23N7O/c1-14-25-19(17-7-6-10-24-22(17)27-15(2)31)11-21(26-14)30-12-16(13-30)23-28-18-8-4-5-9-20(18)29(23)3/h4-11,16H,12-13H2,1-3H3,(H,24,27,31)
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75n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236043
PNG
(US9365562, 81)
Show SMILES Cc1nc(cc(n1)-c1cccnc1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H20N6/c1-14-23-18(15-6-5-9-22-11-15)10-20(24-14)27-12-16(13-27)21-25-17-7-3-4-8-19(17)26(21)2/h3-11,16H,12-13H2,1-2H3
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76n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236042
PNG
(US9365562, 80)
Show SMILES Cc1nc(cc(n1)-c1cccnc1C)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H22N6/c1-14-17(7-6-10-23-14)19-11-21(25-15(2)24-19)28-12-16(13-28)22-26-18-8-4-5-9-20(18)27(22)3/h4-11,16H,12-13H2,1-3H3
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>100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236088
PNG
(US9365562, 126)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1ccc(C)cn1
Show InChI InChI=1S/C18H21N7/c1-11-5-6-16(19-8-11)15-9-24(10-15)17-7-18(22-12(2)21-17)25-14(4)20-13(3)23-25/h5-8,15H,9-10H2,1-4H3
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407n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%