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Patent code US9365563

Compile Data Set for Download or QSAR

Found 228 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236215
PNG
(US9365563, K6)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncc(cc2Cl)[C@H](O)CO)cc1
Show InChI InChI=1S/C22H29ClN4O3/c1-22(2,3)16-4-6-17(7-5-16)25-21(30)27-10-8-26(9-11-27)20-18(23)12-15(13-24-20)19(29)14-28/h4-7,12-13,19,28-29H,8-11,14H2,1-3H3,(H,25,30)/t19-/m1/s1
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n/an/a 0.800n/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236092
PNG
(US9365563, D1)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCC(=CC2)c2ncc(cc2F)[C@H](O)CO)cc1
Show InChI InChI=1S/C23H28FN3O3/c1-23(2,3)17-4-6-18(7-5-17)26-22(30)27-10-8-15(9-11-27)21-19(24)12-16(13-25-21)20(29)14-28/h4-8,12-13,20,28-29H,9-11,14H2,1-3H3,(H,26,30)/t20-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236097
PNG
(US9365563, I1)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCC(=CC2)c2ncc(cc2Cl)[C@H](O)CO)cc1
Show InChI InChI=1S/C23H28ClN3O3/c1-23(2,3)17-4-6-18(7-5-17)26-22(30)27-10-8-15(9-11-27)21-19(24)12-16(13-25-21)20(29)14-28/h4-8,12-13,20,28-29H,9-11,14H2,1-3H3,(H,26,30)/t20-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236217
PNG
(US9365563, M6)
Show SMILES OC[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2ccc(cc2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C19H20ClF3N4O3/c20-15-9-12(16(29)11-28)10-24-17(15)26-5-7-27(8-6-26)18(30)25-14-3-1-13(2-4-14)19(21,22)23/h1-4,9-10,16,28-29H,5-8,11H2,(H,25,30)/t16-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236157
PNG
(US9365563, Q3)
Show SMILES OC[C@@H](O)c1cnc(c(F)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C20H19ClF5N3O3/c21-14-8-12(1-2-13(14)20(24,25)26)28-18(32)29-5-3-19(23,4-6-29)17-15(22)7-11(9-27-17)16(31)10-30/h1-2,7-9,16,30-31H,3-6,10H2,(H,28,32)/t16-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236101
PNG
(US9365563, M1)
Show SMILES OC[C@@H](O)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C20H19Cl2F4N3O4/c21-13-8-12(1-2-16(13)33-20(24,25)26)28-18(32)29-5-3-19(23,4-6-29)17-14(22)7-11(9-27-17)15(31)10-30/h1-2,7-9,15,30-31H,3-6,10H2,(H,28,32)/t15-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236216
PNG
(US9365563, L6)
Show SMILES OC[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)c(Cl)c1
Show InChI InChI=1S/C19H20ClF3N4O4/c20-15-9-12(16(29)11-28)10-24-17(15)26-5-7-27(8-6-26)18(30)25-13-1-3-14(4-2-13)31-19(21,22)23/h1-4,9-10,16,28-29H,5-8,11H2,(H,25,30)/t16-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236166
PNG
(US9365563, B4)
Show SMILES OC[C@H](O)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(cc1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C20H20ClF4N3O5S/c21-15-9-12(16(30)11-29)10-26-17(15)19(22)5-7-28(8-6-19)18(31)27-13-1-3-14(4-2-13)34(32,33)20(23,24)25/h1-4,9-10,16,29-30H,5-8,11H2,(H,27,31)/t16-/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236218
PNG
(US9365563, V6)
Show SMILES OC[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(F)cc3s2)c(Cl)c1
Show InChI InChI=1S/C19H19ClFN5O3S/c20-13-7-11(15(28)10-27)9-22-17(13)25-3-5-26(6-4-25)19(29)24-18-23-14-2-1-12(21)8-16(14)30-18/h1-2,7-9,15,27-28H,3-6,10H2,(H,23,24,29)/t15-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236102
PNG
(US9365563, N1)
Show SMILES OC[C@@H](O)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H20ClF4N3O3/c21-15-9-12(16(30)11-29)10-26-17(15)19(22)5-7-28(8-6-19)18(31)27-14-3-1-13(2-4-14)20(23,24)25/h1-4,9-10,16,29-30H,5-8,11H2,(H,27,31)/t16-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236217
PNG
(US9365563, M6)
Show SMILES OC[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2ccc(cc2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C19H20ClF3N4O3/c20-15-9-12(16(29)11-28)10-24-17(15)26-5-7-27(8-6-26)18(30)25-14-3-1-13(2-4-14)19(21,22)23/h1-4,9-10,16,28-29H,5-8,11H2,(H,25,30)/t16-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236089
PNG
(US9365563, A1)
Show SMILES OCC(O)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H20ClF4N3O3/c21-15-9-12(16(30)11-29)10-26-17(15)19(22)5-7-28(8-6-19)18(31)27-14-3-1-13(2-4-14)20(23,24)25/h1-4,9-10,16,29-30H,5-8,11H2,(H,27,31)
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236090
PNG
(US9365563, B1)
Show SMILES OC[C@H](O)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H20ClF4N3O3/c21-15-9-12(16(30)11-29)10-26-17(15)19(22)5-7-28(8-6-19)18(31)27-14-3-1-13(2-4-14)20(23,24)25/h1-4,9-10,16,29-30H,5-8,11H2,(H,27,31)/t16-/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236090
PNG
(US9365563, B1)
Show SMILES OC[C@H](O)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H20ClF4N3O3/c21-15-9-12(16(30)11-29)10-26-17(15)19(22)5-7-28(8-6-19)18(31)27-14-3-1-13(2-4-14)20(23,24)25/h1-4,9-10,16,29-30H,5-8,11H2,(H,27,31)/t16-/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236105
PNG
(US9365563, Q1)
Show SMILES OC[C@@H](O)c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cc2)S(=O)(=O)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C20H19ClF3N3O5S/c21-16-9-13(17(29)11-28)10-25-18(16)12-5-7-27(8-6-12)19(30)26-14-1-3-15(4-2-14)33(31,32)20(22,23)24/h1-5,9-10,17,28-29H,6-8,11H2,(H,26,30)/t17-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236207
PNG
(US9365563, A6)
Show SMILES OC[C@H](O)c1cnc(c(F)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1S/C20H19F6N3O3/c21-14-8-12(1-2-13(14)20(24,25)26)28-18(32)29-5-3-19(23,4-6-29)17-15(22)7-11(9-27-17)16(31)10-30/h1-2,7-9,16,30-31H,3-6,10H2,(H,28,32)/t16-/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236094
PNG
(US9365563, F1)
Show SMILES OC[C@@H](O)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1S/C20H19ClF5N3O3/c21-14-7-11(16(31)10-30)9-27-17(14)19(23)3-5-29(6-4-19)18(32)28-12-1-2-13(15(22)8-12)20(24,25)26/h1-2,7-9,16,30-31H,3-6,10H2,(H,28,32)/t16-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236159
PNG
(US9365563, S3)
Show SMILES Cc1cc(NC(=O)N2CCC(=CC2)c2ncc(cc2F)[C@H](O)CO)ccc1OC(F)(F)F
Show InChI InChI=1S/C21H21F4N3O4/c1-12-8-15(2-3-18(12)32-21(23,24)25)27-20(31)28-6-4-13(5-7-28)19-16(22)9-14(10-26-19)17(30)11-29/h2-4,8-10,17,29-30H,5-7,11H2,1H3,(H,27,31)/t17-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236111
PNG
(US9365563, W1)
Show SMILES OC[C@@H](O)c1cnc(C2=CCN(CC2)C(=O)Nc2nc3ccc(Cl)cc3s2)c(Cl)c1
Show InChI InChI=1S/C20H18Cl2N4O3S/c21-13-1-2-15-17(8-13)30-19(24-15)25-20(29)26-5-3-11(4-6-26)18-14(22)7-12(9-23-18)16(28)10-27/h1-3,7-9,16,27-28H,4-6,10H2,(H,24,25,29)/t16-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236215
PNG
(US9365563, K6)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncc(cc2Cl)[C@H](O)CO)cc1
Show InChI InChI=1S/C22H29ClN4O3/c1-22(2,3)16-4-6-17(7-5-16)25-21(30)27-10-8-26(9-11-27)20-18(23)12-15(13-24-20)19(29)14-28/h4-7,12-13,19,28-29H,8-11,14H2,1-3H3,(H,25,30)/t19-/m1/s1
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Purdue Pharma L.P.

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Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236202
PNG
(US9365563, V5)
Show SMILES Cc1cc(NC(=O)N2CCC(F)(CC2)c2ncc(cc2Cl)[C@@H](O)CO)ccc1OC(F)(F)F
Show InChI InChI=1S/C21H22ClF4N3O4/c1-12-8-14(2-3-17(12)33-21(24,25)26)28-19(32)29-6-4-20(23,5-7-29)18-15(22)9-13(10-27-18)16(31)11-30/h2-3,8-10,16,30-31H,4-7,11H2,1H3,(H,28,32)/t16-/m0/s1
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Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236118
PNG
(US9365563, D2)
Show SMILES OC[C@@H](O)c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C20H18Cl2F3N3O3/c21-15-8-13(1-2-14(15)20(23,24)25)27-19(31)28-5-3-11(4-6-28)18-16(22)7-12(9-26-18)17(30)10-29/h1-3,7-9,17,29-30H,4-6,10H2,(H,27,31)/t17-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236091
PNG
(US9365563, C1)
Show SMILES OC[C@@H](O)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C20H20ClF4N3O4/c21-15-9-12(16(30)11-29)10-26-17(15)19(22)5-7-28(8-6-19)18(31)27-13-1-3-14(4-2-13)32-20(23,24)25/h1-4,9-10,16,29-30H,5-8,11H2,(H,27,31)/t16-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236114
PNG
(US9365563, Z1)
Show SMILES OC[C@@H](O)c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cc2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C20H19ClF3N3O3/c21-16-9-13(17(29)11-28)10-25-18(16)12-5-7-27(8-6-12)19(30)26-15-3-1-14(2-4-15)20(22,23)24/h1-5,9-10,17,28-29H,6-8,11H2,(H,26,30)/t17-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236160
PNG
(US9365563, T3)
Show SMILES OC[C@H](O)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C20H19Cl2F4N3O3/c21-14-8-12(1-2-13(14)20(24,25)26)28-18(32)29-5-3-19(23,4-6-29)17-15(22)7-11(9-27-17)16(31)10-30/h1-2,7-9,16,30-31H,3-6,10H2,(H,28,32)/t16-/m0/s1
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Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236122
PNG
(US9365563, H2)
Show SMILES OC[C@@H](O)c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)c(Cl)c2)c(Cl)c1
Show InChI InChI=1S/C20H18Cl2F3N3O4/c21-14-8-13(1-2-17(14)32-20(23,24)25)27-19(31)28-5-3-11(4-6-28)18-15(22)7-12(9-26-18)16(30)10-29/h1-3,7-9,16,29-30H,4-6,10H2,(H,27,31)/t16-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236113
PNG
(US9365563, Y1)
Show SMILES OC[C@@H](O)c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)c(Cl)c2)c(F)c1
Show InChI InChI=1S/C20H18ClF4N3O4/c21-14-8-13(1-2-17(14)32-20(23,24)25)27-19(31)28-5-3-11(4-6-28)18-15(22)7-12(9-26-18)16(30)10-29/h1-3,7-9,16,29-30H,4-6,10H2,(H,27,31)/t16-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236161
PNG
(US9365563, U3)
Show SMILES OC[C@@H](O)c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C20H18ClF4N3O3/c21-15-8-13(1-2-14(15)20(23,24)25)27-19(31)28-5-3-11(4-6-28)18-16(22)7-12(9-26-18)17(30)10-29/h1-3,7-9,17,29-30H,4-6,10H2,(H,27,31)/t17-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236216
PNG
(US9365563, L6)
Show SMILES OC[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)c(Cl)c1
Show InChI InChI=1S/C19H20ClF3N4O4/c20-15-9-12(16(29)11-28)10-24-17(15)26-5-7-27(8-6-26)18(30)25-13-1-3-14(4-2-13)31-19(21,22)23/h1-4,9-10,16,28-29H,5-8,11H2,(H,25,30)/t16-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236157
PNG
(US9365563, Q3)
Show SMILES OC[C@@H](O)c1cnc(c(F)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C20H19ClF5N3O3/c21-14-8-12(1-2-13(14)20(24,25)26)28-18(32)29-5-3-19(23,4-6-29)17-15(22)7-11(9-27-17)16(31)10-30/h1-2,7-9,16,30-31H,3-6,10H2,(H,28,32)/t16-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236109
PNG
(US9365563, U1)
Show SMILES OC[C@@H](O)c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C20H19F4N3O3/c21-16-9-13(17(29)11-28)10-25-18(16)12-5-7-27(8-6-12)19(30)26-15-3-1-14(2-4-15)20(22,23)24/h1-5,9-10,17,28-29H,6-8,11H2,(H,26,30)/t17-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236219
PNG
(US9365563, W6)
Show SMILES OC[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C19H19Cl2F3N4O3/c20-14-2-1-12(8-13(14)19(22,23)24)26-18(31)28-5-3-27(4-6-28)17-15(21)7-11(9-25-17)16(30)10-29/h1-2,7-9,16,29-30H,3-6,10H2,(H,26,31)/t16-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236183
PNG
(US9365563, B5)
Show SMILES OC[C@@H](O)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(Br)c(c1)C(F)(F)F
Show InChI InChI=1S/C20H19BrClF4N3O3/c21-14-2-1-12(8-13(14)20(24,25)26)28-18(32)29-5-3-19(23,4-6-29)17-15(22)7-11(9-27-17)16(31)10-30/h1-2,7-9,16,30-31H,3-6,10H2,(H,28,32)/t16-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236091
PNG
(US9365563, C1)
Show SMILES OC[C@@H](O)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C20H20ClF4N3O4/c21-15-9-12(16(30)11-29)10-26-17(15)19(22)5-7-28(8-6-19)18(31)27-13-1-3-14(4-2-13)32-20(23,24)25/h1-4,9-10,16,29-30H,5-8,11H2,(H,27,31)/t16-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236158
PNG
(US9365563, R3)
Show SMILES Cc1cc(NC(=O)N2CCC(F)(CC2)c2ncc(cc2F)[C@H](O)CO)ccc1OC(F)(F)F
Show InChI InChI=1S/C21H22F5N3O4/c1-12-8-14(2-3-17(12)33-21(24,25)26)28-19(32)29-6-4-20(23,5-7-29)18-15(22)9-13(10-27-18)16(31)11-30/h2-3,8-10,16,30-31H,4-7,11H2,1H3,(H,28,32)/t16-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236218
PNG
(US9365563, V6)
Show SMILES OC[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(F)cc3s2)c(Cl)c1
Show InChI InChI=1S/C19H19ClFN5O3S/c20-13-7-11(15(28)10-27)9-22-17(13)25-3-5-26(6-4-25)19(29)24-18-23-14-2-1-12(21)8-16(14)30-18/h1-2,7-9,15,27-28H,3-6,10H2,(H,23,24,29)/t15-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236107
PNG
(US9365563, S1)
Show SMILES OC[C@@H](O)c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(F)c2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C20H18ClF4N3O3/c21-15-7-12(17(30)10-29)9-26-18(15)11-3-5-28(6-4-11)19(31)27-13-1-2-14(16(22)8-13)20(23,24)25/h1-3,7-9,17,29-30H,4-6,10H2,(H,27,31)/t17-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236095
PNG
(US9365563, G1)
Show SMILES OC[C@@H](O)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C19H19ClF4N4O3/c20-13-7-11(14(30)10-29)8-26-16(13)18(21)3-5-28(6-4-18)17(31)27-15-2-1-12(9-25-15)19(22,23)24/h1-2,7-9,14,29-30H,3-6,10H2,(H,25,27,31)/t14-/m1/s1
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Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236206
PNG
(US9365563, Z5)
Show SMILES OC[C@H](O)c1cnc(c(F)c1)C1(F)CCN(CC1)C(=O)Nc1nc2ccc(Cl)cc2s1
Show InChI InChI=1S/C20H19ClF2N4O3S/c21-12-1-2-14-16(8-12)31-18(25-14)26-19(30)27-5-3-20(23,4-6-27)17-13(22)7-11(9-24-17)15(29)10-28/h1-2,7-9,15,28-29H,3-6,10H2,(H,25,26,30)/t15-/m0/s1
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Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


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More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236182
PNG
(US9365563, Z4)
Show SMILES OC[C@@H](O)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1nc2ccc(Cl)cc2s1
Show InChI InChI=1S/C20H19Cl2FN4O3S/c21-12-1-2-14-16(8-12)31-18(25-14)26-19(30)27-5-3-20(23,4-6-27)17-13(22)7-11(9-24-17)15(29)10-28/h1-2,7-9,15,28-29H,3-6,10H2,(H,25,26,30)/t15-/m1/s1
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n/an/a 16.5n/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236092
PNG
(US9365563, D1)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCC(=CC2)c2ncc(cc2F)[C@H](O)CO)cc1
Show InChI InChI=1S/C23H28FN3O3/c1-23(2,3)17-4-6-18(7-5-17)26-22(30)27-10-8-15(9-11-27)21-19(24)12-16(13-25-21)20(29)14-28/h4-8,12-13,20,28-29H,9-11,14H2,1-3H3,(H,26,30)/t20-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236159
PNG
(US9365563, S3)
Show SMILES Cc1cc(NC(=O)N2CCC(=CC2)c2ncc(cc2F)[C@H](O)CO)ccc1OC(F)(F)F
Show InChI InChI=1S/C21H21F4N3O4/c1-12-8-15(2-3-18(12)32-21(23,24)25)27-20(31)28-6-4-13(5-7-28)19-16(22)9-14(10-26-19)17(30)11-29/h2-4,8-10,17,29-30H,5-7,11H2,1H3,(H,27,31)/t17-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236123
PNG
(US9365563, I2)
Show SMILES CC(C)Oc1ccc(NC(=O)N2CCC(=CC2)c2ncc(CO)cc2Cl)cc1C(F)(F)F
Show InChI InChI=1S/C22H23ClF3N3O3/c1-13(2)32-19-4-3-16(10-17(19)22(24,25)26)28-21(31)29-7-5-15(6-8-29)20-18(23)9-14(12-30)11-27-20/h3-5,9-11,13,30H,6-8,12H2,1-2H3,(H,28,31)
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236098
PNG
(US9365563, J1)
Show SMILES OC[C@@H](O)c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(F)c2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C20H18F5N3O3/c21-15-8-13(1-2-14(15)20(23,24)25)27-19(31)28-5-3-11(4-6-28)18-16(22)7-12(9-26-18)17(30)10-29/h1-3,7-9,17,29-30H,4-6,10H2,(H,27,31)/t17-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236093
PNG
(US9365563, E1)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCC(=CC2)c2ncc(cc2Cl)[C@@H](O)CO)cc1
Show InChI InChI=1S/C23H28ClN3O3/c1-23(2,3)17-4-6-18(7-5-17)26-22(30)27-10-8-15(9-11-27)21-19(24)12-16(13-25-21)20(29)14-28/h4-8,12-13,20,28-29H,9-11,14H2,1-3H3,(H,26,30)/t20-/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236167
PNG
(US9365563, C4)
Show SMILES OC[C@@H](O)c1cnc(C2=CCN(CC2)C(=O)Nc2nc3ccc(Cl)cc3s2)c(F)c1
Show InChI InChI=1S/C20H18ClFN4O3S/c21-13-1-2-15-17(8-13)30-19(24-15)25-20(29)26-5-3-11(4-6-26)18-14(22)7-12(9-23-18)16(28)10-27/h1-3,7-9,16,27-28H,4-6,10H2,(H,24,25,29)/t16-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236094
PNG
(US9365563, F1)
Show SMILES OC[C@@H](O)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1S/C20H19ClF5N3O3/c21-14-7-11(16(31)10-30)9-27-17(14)19(23)3-5-29(6-4-19)18(32)28-12-1-2-13(15(22)8-12)20(24,25)26/h1-2,7-9,16,30-31H,3-6,10H2,(H,28,32)/t16-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236112
PNG
(US9365563, X1)
Show SMILES CN(C)c1ccc(NC(=O)N2CCC(=CC2)c2ncc(CO)cc2Cl)cc1C(F)(F)F
Show InChI InChI=1S/C21H22ClF3N4O2/c1-28(2)18-4-3-15(10-16(18)21(23,24)25)27-20(31)29-7-5-14(6-8-29)19-17(22)9-13(12-30)11-26-19/h3-5,9-11,30H,6-8,12H2,1-2H3,(H,27,31)
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236129
PNG
(US9365563, O2)
Show SMILES CCCOc1cc(NC(=O)N2CCC(=CC2)c2ncc(CO)cc2Cl)ccc1C(F)(F)F
Show InChI InChI=1S/C22H23ClF3N3O3/c1-2-9-32-19-11-16(3-4-17(19)22(24,25)26)28-21(31)29-7-5-15(6-8-29)20-18(23)10-14(13-30)12-27-20/h3-5,10-12,30H,2,6-9,13H2,1H3,(H,28,31)
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM236201
PNG
(US9365563, U5)
Show SMILES OC[C@H](O)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1S/C20H19ClF5N3O3/c21-14-7-11(16(31)10-30)9-27-17(14)19(23)3-5-29(6-4-19)18(32)28-12-1-2-13(15(22)8-12)20(24,25)26/h1-2,7-9,16,30-31H,3-6,10H2,(H,28,32)/t16-/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%