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Patent code US9388136

Compile Data Set for Download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236625
PNG
(US9388136, Table 1, Compound 17:cyclopentyl N-(2- ...)
Show SMILES CC(C)C[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC1CCCC1
Show InChI InChI=1S/C31H33F4N3O4/c1-17(2)13-26(31(41)42-20-5-3-4-6-20)37-12-11-18-14-24(34)28(25(35)15-18)38-27(39)10-9-22(30(38)36)29(40)21-8-7-19(32)16-23(21)33/h7-10,14-17,20,26,37H,3-6,11-13,36H2,1-2H3/t26-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236615
PNG
(US9388136, Table 1, Compound 1:tert-Butyl N-(2-{4-...)
Show SMILES C[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C27H27F4N3O4/c1-14(26(37)38-27(2,3)4)33-10-9-15-11-20(30)23(21(31)12-15)34-22(35)8-7-18(25(34)32)24(36)17-6-5-16(28)13-19(17)29/h5-8,11-14,33H,9-10,32H2,1-4H3/t14-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236630
PNG
(US9388136, Table 1, Compound 22:tert-butyl (2S)- [...)
Show SMILES CC(C)(C)OC(=O)[C@@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)c1ccccc1
Show InChI InChI=1S/C32H29F4N3O4/c1-32(2,3)43-31(42)27(19-7-5-4-6-8-19)38-14-13-18-15-24(35)28(25(36)16-18)39-26(40)12-11-22(30(39)37)29(41)21-10-9-20(33)17-23(21)34/h4-12,15-17,27,38H,13-14,37H2,1-3H3/t27-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236629
PNG
(US9388136, Table 1, Compound 21:Cyclopentyl (2S)- ...)
Show SMILES Nc1c(ccc(=O)n1-c1c(F)cc(CCN[C@H](C(=O)OC2CCCC2)c2ccccc2)cc1F)C(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C33H29F4N3O4/c34-21-10-11-23(25(35)18-21)31(42)24-12-13-28(41)40(32(24)38)30-26(36)16-19(17-27(30)37)14-15-39-29(20-6-2-1-3-7-20)33(43)44-22-8-4-5-9-22/h1-3,6-7,10-13,16-18,22,29,39H,4-5,8-9,14-15,38H2/t29-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236628
PNG
(US9388136, Table 1, Compound 20:Cyclopentyl N- (2-...)
Show SMILES CC(C)C[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1)C(=O)OC1CCCC1
Show InChI InChI=1S/C31H34F3N3O4/c1-18(2)15-26(31(40)41-22-5-3-4-6-22)36-14-13-19-16-24(33)28(25(34)17-19)37-27(38)12-11-23(30(37)35)29(39)20-7-9-21(32)10-8-20/h7-12,16-18,22,26,36H,3-6,13-15,35H2,1-2H3/t26-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236623
PNG
(US9388136, Table 1, Compound 15:tert-butyl N-(2- {...)
Show SMILES CC(C)C[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H33F4N3O4/c1-16(2)12-24(29(40)41-30(3,4)5)36-11-10-17-13-22(33)26(23(34)14-17)37-25(38)9-8-20(28(37)35)27(39)19-7-6-18(31)15-21(19)32/h6-9,13-16,24,36H,10-12,35H2,1-5H3/t24-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236631
PNG
(US9388136, Table 1, Compound 23:Cyclopentyl N- (2-...)
Show SMILES CC(C)(C)OC[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC1CCCC1
Show InChI InChI=1S/C32H35F4N3O5/c1-32(2,3)43-17-26(31(42)44-20-6-4-5-7-20)38-13-12-18-14-24(35)28(25(36)15-18)39-27(40)11-10-22(30(39)37)29(41)21-9-8-19(33)16-23(21)34/h8-11,14-16,20,26,38H,4-7,12-13,17,37H2,1-3H3/t26-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236632
PNG
(US9388136, Table 1, Compound 24:tert-butyl N-(2- {...)
Show SMILES CC(C)(C)OC[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C31H35F4N3O5/c1-30(2,3)42-16-24(29(41)43-31(4,5)6)37-12-11-17-13-22(34)26(23(35)14-17)38-25(39)10-9-20(28(38)36)27(40)19-8-7-18(32)15-21(19)33/h7-10,13-15,24,37H,11-12,16,36H2,1-6H3/t24-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236619
PNG
(US9388136, Table 1, Compound 11:Cyclopentyl (2S)-4...)
Show SMILES NCC[C@H](NCCCOc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC1CCCC1
Show InChI InChI=1S/C30H32F4N4O5/c31-17-6-7-20(22(32)14-17)28(40)21-8-9-26(39)38(29(21)36)27-23(33)15-19(16-24(27)34)42-13-3-12-37-25(10-11-35)30(41)43-18-4-1-2-5-18/h6-9,14-16,18,25,37H,1-5,10-13,35-36H2/t25-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236624
PNG
(US9388136, Table 1, Compound 16:tert-butyl N-(2- {...)
Show SMILES CC(C)C[C@@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H33F4N3O4/c1-16(2)12-24(29(40)41-30(3,4)5)36-11-10-17-13-22(33)26(23(34)14-17)37-25(38)9-8-20(28(37)35)27(39)19-7-6-18(31)15-21(19)32/h6-9,13-16,24,36H,10-12,35H2,1-5H3/t24-/m1/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236620
PNG
(US9388136, Table 1, Compound 12:Cyclopentyl N-(5-{...)
Show SMILES CC(C)C[C@H](NCCCCCOc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC1CCCC1
Show InChI InChI=1S/C34H39F4N3O5/c1-20(2)16-29(34(44)46-22-8-4-5-9-22)40-14-6-3-7-15-45-23-18-27(37)31(28(38)19-23)41-30(42)13-12-25(33(41)39)32(43)24-11-10-21(35)17-26(24)36/h10-13,17-20,22,29,40H,3-9,14-16,39H2,1-2H3/t29-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236618
PNG
(US9388136, Table 1, Compound 5:tert-Butyl N-(5- {4...)
Show SMILES CC(C)C[C@H](NCCCCCOc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C33H39F4N3O5/c1-19(2)15-27(32(43)45-33(3,4)5)39-13-7-6-8-14-44-21-17-25(36)29(26(37)18-21)40-28(41)12-11-23(31(40)38)30(42)22-10-9-20(34)16-24(22)35/h9-12,16-19,27,39H,6-8,13-15,38H2,1-5H3/t27-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236619
PNG
(US9388136, Table 1, Compound 11:Cyclopentyl (2S)-4...)
Show SMILES NCC[C@H](NCCCOc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC1CCCC1
Show InChI InChI=1S/C30H32F4N4O5/c31-17-6-7-20(22(32)14-17)28(40)21-8-9-26(39)38(29(21)36)27-23(33)15-19(16-24(27)34)42-13-3-12-37-25(10-11-35)30(41)43-18-4-1-2-5-18/h6-9,14-16,18,25,37H,1-5,10-13,35-36H2/t25-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236628
PNG
(US9388136, Table 1, Compound 20:Cyclopentyl N- (2-...)
Show SMILES CC(C)C[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1)C(=O)OC1CCCC1
Show InChI InChI=1S/C31H34F3N3O4/c1-18(2)15-26(31(40)41-22-5-3-4-6-22)36-14-13-19-16-24(33)28(25(34)17-19)37-27(38)12-11-23(30(37)35)29(39)20-7-9-21(32)10-8-20/h7-12,16-18,22,26,36H,3-6,13-15,35H2,1-2H3/t26-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236615
PNG
(US9388136, Table 1, Compound 1:tert-Butyl N-(2-{4-...)
Show SMILES C[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C27H27F4N3O4/c1-14(26(37)38-27(2,3)4)33-10-9-15-11-20(30)23(21(31)12-15)34-22(35)8-7-18(25(34)32)24(36)17-6-5-16(28)13-19(17)29/h5-8,11-14,33H,9-10,32H2,1-4H3/t14-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236626
PNG
(US9388136, Table 1, Compound 18:Cyclopentyl N- [2-...)
Show SMILES CC(C)[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC1CCCC1
Show InChI InChI=1S/C30H31F4N3O4/c1-16(2)26(30(40)41-19-5-3-4-6-19)36-12-11-17-13-23(33)27(24(34)14-17)37-25(38)10-9-21(29(37)35)28(39)20-8-7-18(31)15-22(20)32/h7-10,13-16,19,26,36H,3-6,11-12,35H2,1-2H3/t26-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236621
PNG
(US9388136, Table 1, Compound 13:Ethyl N-(3- {4-[6-...)
Show SMILES CCOC(=O)[C@H](CC(C)C)NCCCOc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H32F3N3O5/c1-4-39-29(38)24(14-17(2)3)34-12-5-13-40-20-15-22(31)26(23(32)16-20)35-25(36)11-10-21(28(35)33)27(37)18-6-8-19(30)9-7-18/h6-11,15-17,24,34H,4-5,12-14,33H2,1-3H3/t24-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236630
PNG
(US9388136, Table 1, Compound 22:tert-butyl (2S)- [...)
Show SMILES CC(C)(C)OC(=O)[C@@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)c1ccccc1
Show InChI InChI=1S/C32H29F4N3O4/c1-32(2,3)43-31(42)27(19-7-5-4-6-8-19)38-14-13-18-15-24(35)28(25(36)16-18)39-26(40)12-11-22(30(39)37)29(41)21-10-9-20(33)17-23(21)34/h4-12,15-17,27,38H,13-14,37H2,1-3H3/t27-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236633
PNG
(US9388136, Table 1, Compound 25:Cyclopentyl (2R)- ...)
Show SMILES Nc1c(ccc(=O)n1-c1c(F)cc(CCN[C@@H](C(=O)OC2CCCC2)c2ccccc2)cc1F)C(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C33H29F4N3O4/c34-21-10-11-23(25(35)18-21)31(42)24-12-13-28(41)40(32(24)38)30-26(36)16-19(17-27(30)37)14-15-39-29(20-6-2-1-3-7-20)33(43)44-22-8-4-5-9-22/h1-3,6-7,10-13,16-18,22,29,39H,4-5,8-9,14-15,38H2/t29-/m1/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236627
PNG
(US9388136, Table 1, Compound 19:Cyclopentyl N- [2-...)
Show SMILES C[C@@H](O)C(NCCc1ccc(cc1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC1CCCC1
Show InChI InChI=1S/C29H31F2N3O5/c1-17(35)26(29(38)39-21-4-2-3-5-21)33-15-14-18-6-9-20(10-7-18)34-25(36)13-12-23(28(34)32)27(37)22-11-8-19(30)16-24(22)31/h6-13,16-17,21,26,33,35H,2-5,14-15,32H2,1H3/t17-,26?/m1/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236631
PNG
(US9388136, Table 1, Compound 23:Cyclopentyl N- (2-...)
Show SMILES CC(C)(C)OC[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC1CCCC1
Show InChI InChI=1S/C32H35F4N3O5/c1-32(2,3)43-17-26(31(42)44-20-6-4-5-7-20)38-13-12-18-14-24(35)28(25(36)15-18)39-27(40)11-10-22(30(39)37)29(41)21-9-8-19(33)16-23(21)34/h8-11,14-16,20,26,38H,4-7,12-13,17,37H2,1-3H3/t26-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236622
PNG
(US9388136, Table 1, Compound 14:tert-butyl N- [2-(...)
Show SMILES C[C@H](NCCc1ccc(cc1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C27H29F2N3O4/c1-16(26(35)36-27(2,3)4)31-14-13-17-5-8-19(9-6-17)32-23(33)12-11-21(25(32)30)24(34)20-10-7-18(28)15-22(20)29/h5-12,15-16,31H,13-14,30H2,1-4H3/t16-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236617
PNG
(US9388136, Table 1, Compound 3:tert-Butyl N-[2-(4-...)
Show SMILES CC(C)C[C@H](NCCc1ccc(cc1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H35F2N3O4/c1-18(2)16-25(29(38)39-30(3,4)5)34-15-14-19-6-9-21(10-7-19)35-26(36)13-12-23(28(35)33)27(37)22-11-8-20(31)17-24(22)32/h6-13,17-18,25,34H,14-16,33H2,1-5H3/t25-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236622
PNG
(US9388136, Table 1, Compound 14:tert-butyl N- [2-(...)
Show SMILES C[C@H](NCCc1ccc(cc1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C27H29F2N3O4/c1-16(26(35)36-27(2,3)4)31-14-13-17-5-8-19(9-6-17)32-23(33)12-11-21(25(32)30)24(34)20-10-7-18(28)15-22(20)29/h5-12,15-16,31H,13-14,30H2,1-4H3/t16-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236629
PNG
(US9388136, Table 1, Compound 21:Cyclopentyl (2S)- ...)
Show SMILES Nc1c(ccc(=O)n1-c1c(F)cc(CCN[C@H](C(=O)OC2CCCC2)c2ccccc2)cc1F)C(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C33H29F4N3O4/c34-21-10-11-23(25(35)18-21)31(42)24-12-13-28(41)40(32(24)38)30-26(36)16-19(17-27(30)37)14-15-39-29(20-6-2-1-3-7-20)33(43)44-22-8-4-5-9-22/h1-3,6-7,10-13,16-18,22,29,39H,4-5,8-9,14-15,38H2/t29-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236627
PNG
(US9388136, Table 1, Compound 19:Cyclopentyl N- [2-...)
Show SMILES C[C@@H](O)C(NCCc1ccc(cc1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC1CCCC1
Show InChI InChI=1S/C29H31F2N3O5/c1-17(35)26(29(38)39-21-4-2-3-5-21)33-15-14-18-6-9-20(10-7-18)34-25(36)13-12-23(28(34)32)27(37)22-11-8-19(30)16-24(22)31/h6-13,16-17,21,26,33,35H,2-5,14-15,32H2,1H3/t17-,26?/m1/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236632
PNG
(US9388136, Table 1, Compound 24:tert-butyl N-(2- {...)
Show SMILES CC(C)(C)OC[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C31H35F4N3O5/c1-30(2,3)42-16-24(29(41)43-31(4,5)6)37-12-11-17-13-22(34)26(23(35)14-17)38-25(39)10-9-20(28(38)36)27(40)19-8-7-18(32)15-21(19)33/h7-10,13-15,24,37H,11-12,16,36H2,1-6H3/t24-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236618
PNG
(US9388136, Table 1, Compound 5:tert-Butyl N-(5- {4...)
Show SMILES CC(C)C[C@H](NCCCCCOc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C33H39F4N3O5/c1-19(2)15-27(32(43)45-33(3,4)5)39-13-7-6-8-14-44-21-17-25(36)29(26(37)18-21)40-28(41)12-11-23(31(40)38)30(42)22-10-9-20(34)16-24(22)35/h9-12,16-19,27,39H,6-8,13-15,38H2,1-5H3/t27-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236620
PNG
(US9388136, Table 1, Compound 12:Cyclopentyl N-(5-{...)
Show SMILES CC(C)C[C@H](NCCCCCOc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC1CCCC1
Show InChI InChI=1S/C34H39F4N3O5/c1-20(2)16-29(34(44)46-22-8-4-5-9-22)40-14-6-3-7-15-45-23-18-27(37)31(28(38)19-23)41-30(42)13-12-25(33(41)39)32(43)24-11-10-21(35)17-26(24)36/h10-13,17-20,22,29,40H,3-9,14-16,39H2,1-2H3/t29-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236616
PNG
(US9388136, Table 1, Compound 2:tert-Butyl N-[2-(4-...)
Show SMILES CC(C)C[C@H](NCCc1ccc(cc1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H36FN3O4/c1-19(2)18-25(29(37)38-30(3,4)5)33-17-16-20-6-12-23(13-7-20)34-26(35)15-14-24(28(34)32)27(36)21-8-10-22(31)11-9-21/h6-15,19,25,33H,16-18,32H2,1-5H3/t25-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236623
PNG
(US9388136, Table 1, Compound 15:tert-butyl N-(2- {...)
Show SMILES CC(C)C[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H33F4N3O4/c1-16(2)12-24(29(40)41-30(3,4)5)36-11-10-17-13-22(33)26(23(34)14-17)37-25(38)9-8-20(28(37)35)27(39)19-7-6-18(31)15-21(19)32/h6-9,13-16,24,36H,10-12,35H2,1-5H3/t24-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236624
PNG
(US9388136, Table 1, Compound 16:tert-butyl N-(2- {...)
Show SMILES CC(C)C[C@@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H33F4N3O4/c1-16(2)12-24(29(40)41-30(3,4)5)36-11-10-17-13-22(33)26(23(34)14-17)37-25(38)9-8-20(28(37)35)27(39)19-7-6-18(31)15-21(19)32/h6-9,13-16,24,36H,10-12,35H2,1-5H3/t24-/m1/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236625
PNG
(US9388136, Table 1, Compound 17:cyclopentyl N-(2- ...)
Show SMILES CC(C)C[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC1CCCC1
Show InChI InChI=1S/C31H33F4N3O4/c1-17(2)13-26(31(41)42-20-5-3-4-6-20)37-12-11-18-14-24(34)28(25(35)15-18)38-27(39)10-9-22(30(38)36)29(40)21-8-7-19(32)16-23(21)33/h7-10,14-17,20,26,37H,3-6,11-13,36H2,1-2H3/t26-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236617
PNG
(US9388136, Table 1, Compound 3:tert-Butyl N-[2-(4-...)
Show SMILES CC(C)C[C@H](NCCc1ccc(cc1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H35F2N3O4/c1-18(2)16-25(29(38)39-30(3,4)5)34-15-14-19-6-9-21(10-7-19)35-26(36)13-12-23(28(35)33)27(37)22-11-8-20(31)17-24(22)32/h6-13,17-18,25,34H,14-16,33H2,1-5H3/t25-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM236616
PNG
(US9388136, Table 1, Compound 2:tert-Butyl N-[2-(4-...)
Show SMILES CC(C)C[C@H](NCCc1ccc(cc1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H36FN3O4/c1-19(2)18-25(29(37)38-30(3,4)5)33-17-16-20-6-12-23(13-7-20)34-26(35)15-14-24(28(34)32)27(36)21-8-10-22(31)11-9-21/h6-15,19,25,33H,16-18,32H2,1-5H3/t25-/m0/s1
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Chroma Therapeutics Ltd

US Patent


Assay Description
The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%