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Patent code US9388149

Compile Data Set for Download or QSAR
Found 69 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236795
PNG
(US9388149, 2 (Diastereoisomer 1) | US9388149, 2 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3
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n/an/a 15n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236787
PNG
(US9388149, 18)
Show SMILES CN(CC(F)(F)F)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C24H24F3N3O5S/c1-12-8-9-15(35-12)17(16-7-4-10-36-16)29-19-18(21(32)22(19)33)28-14-6-3-5-13(20(14)31)23(34)30(2)11-24(25,26)27/h3,5-6,8-9,16-17,28-29,31H,4,7,10-11H2,1-2H3/t16?,17-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236813
PNG
(US9388149, 10 (Diastereoisomer 1) | US9388149, 10 ...)
Show SMILES CN(C)S(=O)(=O)c1c(Cl)ccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C22H24ClN3O6S2/c1-11-6-9-14(32-11)16(15-5-4-10-33-15)25-18-17(20(28)21(18)29)24-13-8-7-12(23)22(19(13)27)34(30,31)26(2)3/h6-9,15-16,24-25,27H,4-5,10H2,1-3H3
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n/an/a 16n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236791
PNG
(US9388149, 22)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1c(Cl)ccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C25H29ClN4O6S2/c1-14-5-8-17(36-14)19(18-4-3-13-37-18)28-21-20(23(32)24(21)33)27-16-7-6-15(26)25(22(16)31)38(34,35)30-11-9-29(2)10-12-30/h5-8,18-19,27-28,31H,3-4,9-13H2,1-2H3
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n/an/a 17n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236788
PNG
(US9388149, 19)
Show SMILES COC(=O)CN(C)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C25H27N3O7S/c1-13-9-10-16(35-13)19(17-8-5-11-36-17)27-21-20(23(31)24(21)32)26-15-7-4-6-14(22(15)30)25(33)28(2)12-18(29)34-3/h4,6-7,9-10,17,19,26-27,30H,5,8,11-12H2,1-3H3/t17?,19-/m0/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236813
PNG
(US9388149, 10 (Diastereoisomer 1) | US9388149, 10 ...)
Show SMILES CN(C)S(=O)(=O)c1c(Cl)ccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C22H24ClN3O6S2/c1-11-6-9-14(32-11)16(15-5-4-10-33-15)25-18-17(20(28)21(18)29)24-13-8-7-12(23)22(19(13)27)34(30,31)26(2)3/h6-9,15-16,24-25,27H,4-5,10H2,1-3H3
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n/an/a 20n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236789
PNG
(US9388149, 20)
Show SMILES COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3/t17-,19?,20?/m1/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236785
PNG
(US9388149, 16)
Show SMILES Cc1ccc(o1)C(Nc1c(Nc2cccnc2O)c(=O)c1=O)C1CCCS1
Show InChI InChI=1S/C19H19N3O4S/c1-10-6-7-12(26-10)14(13-5-3-9-27-13)22-16-15(17(23)18(16)24)21-11-4-2-8-20-19(11)25/h2,4,6-8,13-14,21-22H,3,5,9H2,1H3,(H,20,25)
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236806
PNG
(US9388149, 6 | US9388149, 7 (Diastereoisomer 1))
Show SMILES COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3/t17-,19?,20?/m1/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236791
PNG
(US9388149, 22)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1c(Cl)ccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C25H29ClN4O6S2/c1-14-5-8-17(36-14)19(18-4-3-13-37-18)28-21-20(23(32)24(21)33)27-16-7-6-15(26)25(22(16)31)38(34,35)30-11-9-29(2)10-12-30/h5-8,18-19,27-28,31H,3-4,9-13H2,1-2H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236795
PNG
(US9388149, 2 (Diastereoisomer 1) | US9388149, 2 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236787
PNG
(US9388149, 18)
Show SMILES CN(CC(F)(F)F)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C24H24F3N3O5S/c1-12-8-9-15(35-12)17(16-7-4-10-36-16)29-19-18(21(32)22(19)33)28-14-6-3-5-13(20(14)31)23(34)30(2)11-24(25,26)27/h3,5-6,8-9,16-17,28-29,31H,4,7,10-11H2,1-2H3/t16?,17-/m0/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236807
PNG
(US9388149, 7 (Diastereoisomer 2))
Show SMILES COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3/t17-,19?,20?/m0/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236788
PNG
(US9388149, 19)
Show SMILES COC(=O)CN(C)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C25H27N3O7S/c1-13-9-10-16(35-13)19(17-8-5-11-36-17)27-21-20(23(31)24(21)32)26-15-7-4-6-14(22(15)30)25(33)28(2)12-18(29)34-3/h4,6-7,9-10,17,19,26-27,30H,5,8,11-12H2,1-3H3/t17?,19-/m0/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236789
PNG
(US9388149, 20)
Show SMILES COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3/t17-,19?,20?/m1/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236795
PNG
(US9388149, 2 (Diastereoisomer 1) | US9388149, 2 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236786
PNG
(US9388149, 17)
Show SMILES CN1C=CC=C(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)C1O
Show InChI InChI=1S/C20H23N3O4S/c1-11-7-8-13(27-11)15(14-6-4-10-28-14)22-17-16(18(24)19(17)25)21-12-5-3-9-23(2)20(12)26/h3,5,7-9,14-15,20-22,26H,4,6,10H2,1-2H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236809
PNG
(US9388149, 8 (Diastereoisomer 2))
Show SMILES CN(CC(F)(F)F)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C24H24F3N3O5S/c1-12-8-9-15(35-12)17(16-7-4-10-36-16)29-19-18(21(32)22(19)33)28-14-6-3-5-13(20(14)31)23(34)30(2)11-24(25,26)27/h3,5-6,8-9,16-17,28-29,31H,4,7,10-11H2,1-2H3/t16?,17-/m0/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236792
PNG
(US9388149, 1 (Diastereoisomer 1) | US9388149, 1 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(c3ccc(C)o3)C3(C)CCCO3)c(=O)c2=O)c1O
Show InChI InChI=1S/C24H27N3O6/c1-13-9-10-16(33-13)22(24(2)11-6-12-32-24)26-18-17(20(29)21(18)30)25-15-8-5-7-14(19(15)28)23(31)27(3)4/h5,7-10,22,25-26,28H,6,11-12H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236795
PNG
(US9388149, 2 (Diastereoisomer 1) | US9388149, 2 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236790
PNG
(US9388149, 21)
Show SMILES CN(C)C(=O)c1c(Cl)ccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H24ClN3O5S/c1-11-6-9-14(32-11)17(15-5-4-10-33-15)26-19-18(21(29)22(19)30)25-13-8-7-12(24)16(20(13)28)23(31)27(2)3/h6-9,15,17,25-26,28H,4-5,10H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236795
PNG
(US9388149, 2 (Diastereoisomer 1) | US9388149, 2 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236811
PNG
(US9388149, 9 (Diastereoisomer 1) | US9388149, 9 (D...)
Show SMILES COC(=O)CNCC(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C25H27N3O7S/c1-13-8-9-17(35-13)20(18-7-4-10-36-18)28-22-21(24(32)25(22)33)27-15-6-3-5-14(23(15)31)16(29)11-26-12-19(30)34-2/h3,5-6,8-9,18,20,26-28,31H,4,7,10-12H2,1-2H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236781
PNG
(US9388149, 12)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC([C@@H]3CCCO3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O6/c1-12-9-10-16(32-12)17(15-8-5-11-31-15)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,15,17,24-25,27H,5,8,11H2,1-3H3/t15-,17?/m0/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236809
PNG
(US9388149, 8 (Diastereoisomer 2))
Show SMILES CN(CC(F)(F)F)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C24H24F3N3O5S/c1-12-8-9-15(35-12)17(16-7-4-10-36-16)29-19-18(21(32)22(19)33)28-14-6-3-5-13(20(14)31)23(34)30(2)11-24(25,26)27/h3,5-6,8-9,16-17,28-29,31H,4,7,10-11H2,1-2H3/t16?,17-/m0/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236806
PNG
(US9388149, 6 | US9388149, 7 (Diastereoisomer 1))
Show SMILES COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3/t17-,19?,20?/m1/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236811
PNG
(US9388149, 9 (Diastereoisomer 1) | US9388149, 9 (D...)
Show SMILES COC(=O)CNCC(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C25H27N3O7S/c1-13-8-9-17(35-13)20(18-7-4-10-36-18)28-22-21(24(32)25(22)33)27-15-6-3-5-14(23(15)31)16(29)11-26-12-19(30)34-2/h3,5-6,8-9,18,20,26-28,31H,4,7,10-12H2,1-2H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236792
PNG
(US9388149, 1 (Diastereoisomer 1) | US9388149, 1 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(c3ccc(C)o3)C3(C)CCCO3)c(=O)c2=O)c1O
Show InChI InChI=1S/C24H27N3O6/c1-13-9-10-16(33-13)22(24(2)11-6-12-32-24)26-18-17(20(29)21(18)30)25-15-8-5-7-14(19(15)28)23(31)27(3)4/h5,7-10,22,25-26,28H,6,11-12H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236792
PNG
(US9388149, 1 (Diastereoisomer 1) | US9388149, 1 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(c3ccc(C)o3)C3(C)CCCO3)c(=O)c2=O)c1O
Show InChI InChI=1S/C24H27N3O6/c1-13-9-10-16(33-13)22(24(2)11-6-12-32-24)26-18-17(20(29)21(18)30)25-15-8-5-7-14(19(15)28)23(31)27(3)4/h5,7-10,22,25-26,28H,6,11-12H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236805
PNG
(US9388149, 5)
Show SMILES CCOC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F
Show InChI InChI=1S/C28H30FN3O6S/c1-3-37-28(36)18-9-5-13-32(18)27(35)16-7-4-8-17(21(16)29)30-23-24(26(34)25(23)33)31-22(20-10-6-14-39-20)19-12-11-15(2)38-19/h4,7-8,11-12,18,20,22,30-31H,3,5-6,9-10,13-14H2,1-2H3/t18-,20?,22?/m0/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236806
PNG
(US9388149, 6 | US9388149, 7 (Diastereoisomer 1))
Show SMILES COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3/t17-,19?,20?/m1/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236804
PNG
(US9388149, 4)
Show SMILES CC(C)OC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F
Show InChI InChI=1S/C29H32FN3O6S/c1-15(2)38-29(37)19-9-5-13-33(19)28(36)17-7-4-8-18(22(17)30)31-24-25(27(35)26(24)34)32-23(21-10-6-14-40-21)20-12-11-16(3)39-20/h4,7-8,11-12,15,19,21,23,31-32H,5-6,9-10,13-14H2,1-3H3/t19-,21?,23?/m0/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236790
PNG
(US9388149, 21)
Show SMILES CN(C)C(=O)c1c(Cl)ccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H24ClN3O5S/c1-11-6-9-14(32-11)17(15-5-4-10-33-15)26-19-18(21(29)22(19)30)25-13-8-7-12(24)16(20(13)28)23(31)27(2)3/h6-9,15,17,25-26,28H,4-5,10H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236810
PNG
(US9388149, 8 (Diastereoisomer 1))
Show SMILES CN(CC(F)(F)F)C(=O)c1cccc(Nc2c(N[C@@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C24H24F3N3O5S/c1-12-8-9-15(35-12)17(16-7-4-10-36-16)29-19-18(21(32)22(19)33)28-14-6-3-5-13(20(14)31)23(34)30(2)11-24(25,26)27/h3,5-6,8-9,16-17,28-29,31H,4,7,10-11H2,1-2H3/t16?,17-/m1/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236795
PNG
(US9388149, 2 (Diastereoisomer 1) | US9388149, 2 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236795
PNG
(US9388149, 2 (Diastereoisomer 1) | US9388149, 2 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236811
PNG
(US9388149, 9 (Diastereoisomer 1) | US9388149, 9 (D...)
Show SMILES COC(=O)CNCC(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C25H27N3O7S/c1-13-8-9-17(35-13)20(18-7-4-10-36-18)28-22-21(24(32)25(22)33)27-15-6-3-5-14(23(15)31)16(29)11-26-12-19(30)34-2/h3,5-6,8-9,18,20,26-28,31H,4,7,10-12H2,1-2H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236782
PNG
(US9388149, 13)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCO3)c3ccccc3)c(=O)c2=O)c1O
Show InChI InChI=1S/C24H25N3O5/c1-27(2)24(31)15-10-6-11-16(21(15)28)25-19-20(23(30)22(19)29)26-18(17-12-7-13-32-17)14-8-4-3-5-9-14/h3-6,8-11,17-18,25-26,28H,7,12-13H2,1-2H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236807
PNG
(US9388149, 7 (Diastereoisomer 2))
Show SMILES COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3/t17-,19?,20?/m0/s1
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n/an/a 171n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236780
PNG
(US9388149, 11)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC([C@H]3CCCO3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O6/c1-12-9-10-16(32-12)17(15-8-5-11-31-15)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,15,17,24-25,27H,5,8,11H2,1-3H3/t15-,17?/m1/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236801
PNG
(US9388149, 3 (Enantiomer 1))
Show SMILES COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC([C@H]3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F
Show InChI InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3/t17-,19+,21?/m0/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236803
PNG
(US9388149, 3 (Mixture of enantiomers 1 and 2))
Show SMILES COC(=O)C1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F
Show InChI InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236792
PNG
(US9388149, 1 (Diastereoisomer 1) | US9388149, 1 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(c3ccc(C)o3)C3(C)CCCO3)c(=O)c2=O)c1O
Show InChI InChI=1S/C24H27N3O6/c1-13-9-10-16(33-13)22(24(2)11-6-12-32-24)26-18-17(20(29)21(18)30)25-15-8-5-7-14(19(15)28)23(31)27(3)4/h5,7-10,22,25-26,28H,6,11-12H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236813
PNG
(US9388149, 10 (Diastereoisomer 1) | US9388149, 10 ...)
Show SMILES CN(C)S(=O)(=O)c1c(Cl)ccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C22H24ClN3O6S2/c1-11-6-9-14(32-11)16(15-5-4-10-33-15)25-18-17(20(28)21(18)29)24-13-8-7-12(23)22(19(13)27)34(30,31)26(2)3/h6-9,15-16,24-25,27H,4-5,10H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236795
PNG
(US9388149, 2 (Diastereoisomer 1) | US9388149, 2 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236784
PNG
(US9388149, 15)
Show SMILES COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F
Show InChI InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3/t17-,19?,21?/m0/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236786
PNG
(US9388149, 17)
Show SMILES CN1C=CC=C(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)C1O
Show InChI InChI=1S/C20H23N3O4S/c1-11-7-8-13(27-11)15(14-6-4-10-28-14)22-17-16(18(24)19(17)25)21-12-5-3-9-23(2)20(12)26/h3,5,7-9,14-15,20-22,26H,4,6,10H2,1-2H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236781
PNG
(US9388149, 12)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC([C@@H]3CCCO3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O6/c1-12-9-10-16(32-12)17(15-8-5-11-31-15)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,15,17,24-25,27H,5,8,11H2,1-3H3/t15-,17?/m0/s1
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n/an/a 483n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236810
PNG
(US9388149, 8 (Diastereoisomer 1))
Show SMILES CN(CC(F)(F)F)C(=O)c1cccc(Nc2c(N[C@@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C24H24F3N3O5S/c1-12-8-9-15(35-12)17(16-7-4-10-36-16)29-19-18(21(32)22(19)33)28-14-6-3-5-13(20(14)31)23(34)30(2)11-24(25,26)27/h3,5-6,8-9,16-17,28-29,31H,4,7,10-11H2,1-2H3/t16?,17-/m1/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236801
PNG
(US9388149, 3 (Enantiomer 1))
Show SMILES COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC([C@H]3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F
Show InChI InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3/t17-,19+,21?/m0/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236811
PNG
(US9388149, 9 (Diastereoisomer 1) | US9388149, 9 (D...)
Show SMILES COC(=O)CNCC(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C25H27N3O7S/c1-13-8-9-17(35-13)20(18-7-4-10-36-18)28-22-21(24(32)25(22)33)27-15-6-3-5-14(23(15)31)16(29)11-26-12-19(30)34-2/h3,5-6,8-9,18,20,26-28,31H,4,7,10-12H2,1-2H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236785
PNG
(US9388149, 16)
Show SMILES Cc1ccc(o1)C(Nc1c(Nc2cccnc2O)c(=O)c1=O)C1CCCS1
Show InChI InChI=1S/C19H19N3O4S/c1-10-6-7-12(26-10)14(13-5-3-9-27-13)22-16-15(17(23)18(16)24)21-11-4-2-8-20-19(11)25/h2,4,6-8,13-14,21-22H,3,5,9H2,1H3,(H,20,25)
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236795
PNG
(US9388149, 2 (Diastereoisomer 1) | US9388149, 2 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236795
PNG
(US9388149, 2 (Diastereoisomer 1) | US9388149, 2 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236805
PNG
(US9388149, 5)
Show SMILES CCOC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F
Show InChI InChI=1S/C28H30FN3O6S/c1-3-37-28(36)18-9-5-13-32(18)27(35)16-7-4-8-17(21(16)29)30-23-24(26(34)25(23)33)31-22(20-10-6-14-39-20)19-12-11-15(2)38-19/h4,7-8,11-12,18,20,22,30-31H,3,5-6,9-10,13-14H2,1-2H3/t18-,20?,22?/m0/s1
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236803
PNG
(US9388149, 3 (Mixture of enantiomers 1 and 2))
Show SMILES COC(=O)C1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F
Show InChI InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236792
PNG
(US9388149, 1 (Diastereoisomer 1) | US9388149, 1 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(c3ccc(C)o3)C3(C)CCCO3)c(=O)c2=O)c1O
Show InChI InChI=1S/C24H27N3O6/c1-13-9-10-16(33-13)22(24(2)11-6-12-32-24)26-18-17(20(29)21(18)30)25-15-8-5-7-14(19(15)28)23(31)27(3)4/h5,7-10,22,25-26,28H,6,11-12H2,1-4H3
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GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236806
PNG
(US9388149, 6 | US9388149, 7 (Diastereoisomer 1))
Show SMILES COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3/t17-,19?,20?/m1/s1
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n/an/a 859n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236802
PNG
(US9388149, 3 (Enantiomer 2))
Show SMILES COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(N[C@@H]([C@@H]3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F
Show InChI InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3/t17-,19-,21+/m0/s1
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n/an/a 982n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236813
PNG
(US9388149, 10 (Diastereoisomer 1) | US9388149, 10 ...)
Show SMILES CN(C)S(=O)(=O)c1c(Cl)ccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C22H24ClN3O6S2/c1-11-6-9-14(32-11)16(15-5-4-10-33-15)25-18-17(20(28)21(18)29)24-13-8-7-12(23)22(19(13)27)34(30,31)26(2)3/h6-9,15-16,24-25,27H,4-5,10H2,1-3H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236782
PNG
(US9388149, 13)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCO3)c3ccccc3)c(=O)c2=O)c1O
Show InChI InChI=1S/C24H25N3O5/c1-27(2)24(31)15-10-6-11-16(21(15)28)25-19-20(23(30)22(19)29)26-18(17-12-7-13-32-17)14-8-4-3-5-9-14/h3-6,8-11,17-18,25-26,28H,7,12-13H2,1-2H3
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n/an/a 1.15E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM236783
PNG
(US9388149, 14 (Diastereoisomer 2))
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC([C@@H]3COC(C)(C)O3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C24H27N3O7/c1-12-9-10-15(33-12)17(16-11-32-24(2,3)34-16)26-19-18(21(29)22(19)30)25-14-8-6-7-13(20(14)28)23(31)27(4)5/h6-10,16-17,25-26,28H,11H2,1-5H3/t16-,17?/m0/s1
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n/an/a 1.25E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236780
PNG
(US9388149, 11)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC([C@H]3CCCO3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O6/c1-12-9-10-16(32-12)17(15-8-5-11-31-15)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,15,17,24-25,27H,5,8,11H2,1-3H3/t15-,17?/m1/s1
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n/an/a 1.32E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236795
PNG
(US9388149, 2 (Diastereoisomer 1) | US9388149, 2 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3
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n/an/a 1.56E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236804
PNG
(US9388149, 4)
Show SMILES CC(C)OC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F
Show InChI InChI=1S/C29H32FN3O6S/c1-15(2)38-29(37)19-9-5-13-33(19)28(36)17-7-4-8-18(22(17)30)31-24-25(27(35)26(24)34)32-23(21-10-6-14-40-21)20-12-11-16(3)39-20/h4,7-8,11-12,15,19,21,23,31-32H,5-6,9-10,13-14H2,1-3H3/t19-,21?,23?/m0/s1
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n/an/a 1.89E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236792
PNG
(US9388149, 1 (Diastereoisomer 1) | US9388149, 1 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(c3ccc(C)o3)C3(C)CCCO3)c(=O)c2=O)c1O
Show InChI InChI=1S/C24H27N3O6/c1-13-9-10-16(33-13)22(24(2)11-6-12-32-24)26-18-17(20(29)21(18)30)25-15-8-5-7-14(19(15)28)23(31)27(3)4/h5,7-10,22,25-26,28H,6,11-12H2,1-4H3
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n/an/a 2.08E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236784
PNG
(US9388149, 15)
Show SMILES COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F
Show InChI InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3/t17-,19?,21?/m0/s1
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n/an/a 3.81E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236795
PNG
(US9388149, 2 (Diastereoisomer 1) | US9388149, 2 (D...)
Show SMILES CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O
Show InChI InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3
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n/an/a 4.55E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM236802
PNG
(US9388149, 3 (Enantiomer 2))
Show SMILES COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(N[C@@H]([C@@H]3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F
Show InChI InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3/t17-,19-,21+/m0/s1
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n/an/a 8.91E+3n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%