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Patent code US9388162

Compile Data Set for Download or QSAR
Found 146 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236866
PNG
(US9388162, 73)
Show SMILES CC(C)[C@@H]1C[C@H]2[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C23H31NO2/c1-14(2)18-11-20-21-9-16-5-6-17(25)10-19(16)23(20,12-22(18)26)7-8-24(21)13-15-3-4-15/h5-6,10,14-15,18,20-21,25H,3-4,7-9,11-13H2,1-2H3/t18-,20-,21+,23+/m0/s1
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US Patent
0.320n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236867
PNG
(US9388162, 74)
Show SMILES CC(C)[C@H]1C[C@H]2[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C23H31NO2/c1-14(2)18-11-20-21-9-16-5-6-17(25)10-19(16)23(20,12-22(18)26)7-8-24(21)13-15-3-4-15/h5-6,10,14-15,18,20-21,25H,3-4,7-9,11-13H2,1-2H3/t18-,20+,21-,23-/m1/s1
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0.330n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236819
PNG
(US9388162, 9)
Show SMILES OC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C22H27NO5/c24-16-4-3-14-7-19-22(28)10-15(8-20(26)27)18(25)11-21(22,17(14)9-16)5-6-23(19)12-13-1-2-13/h3-4,9,13,15,19,24,28H,1-2,5-8,10-12H2,(H,26,27)/t15-,19+,21+,22+/m0/s1
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0.970n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236866
PNG
(US9388162, 73)
Show SMILES CC(C)[C@@H]1C[C@H]2[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C23H31NO2/c1-14(2)18-11-20-21-9-16-5-6-17(25)10-19(16)23(20,12-22(18)26)7-8-24(21)13-15-3-4-15/h5-6,10,14-15,18,20-21,25H,3-4,7-9,11-13H2,1-2H3/t18-,20-,21+,23+/m0/s1
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1.98n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membr...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236819
PNG
(US9388162, 9)
Show SMILES OC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C22H27NO5/c24-16-4-3-14-7-19-22(28)10-15(8-20(26)27)18(25)11-21(22,17(14)9-16)5-6-23(19)12-13-1-2-13/h3-4,9,13,15,19,24,28H,1-2,5-8,10-12H2,(H,26,27)/t15-,19+,21+,22+/m0/s1
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6.18n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membr...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236867
PNG
(US9388162, 74)
Show SMILES CC(C)[C@H]1C[C@H]2[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C23H31NO2/c1-14(2)18-11-20-21-9-16-5-6-17(25)10-19(16)23(20,12-22(18)26)7-8-24(21)13-15-3-4-15/h5-6,10,14-15,18,20-21,25H,3-4,7-9,11-13H2,1-2H3/t18-,20+,21-,23-/m1/s1
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7.42n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membr...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236829
PNG
(US9388162, 48)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CCOCc5ccccc5)C[C@@]34O)c2c1
Show InChI InChI=1S/C30H37NO4/c1-34-25-10-9-23-15-28-30(33)17-24(11-14-35-20-22-5-3-2-4-6-22)27(32)18-29(30,26(23)16-25)12-13-31(28)19-21-7-8-21/h2-6,9-10,16,21,24,28,33H,7-8,11-15,17-20H2,1H3/t24-,28+,29+,30+/m0/s1
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65.3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236865
PNG
(US9388162, 72)
Show SMILES COc1ccc2C[C@@H]3[C@@H]4C[C@@H](C(C)C)C(=O)C[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C24H33NO2/c1-15(2)19-12-21-22-10-17-6-7-18(27-3)11-20(17)24(21,13-23(19)26)8-9-25(22)14-16-4-5-16/h6-7,11,15-16,19,21-22H,4-5,8-10,12-14H2,1-3H3/t19-,21-,22+,24+/m0/s1
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82.9n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236825
PNG
(US9388162, 17)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C27H34N2O6/c30-19-6-5-17-10-23-27(35)13-18(11-24(32)29-8-1-2-21(29)25(33)34)22(31)14-26(27,20(17)12-19)7-9-28(23)15-16-3-4-16/h5-6,12,16,18,21,23,30,35H,1-4,7-11,13-15H2,(H,33,34)/t18-,21-,23+,26+,27+/m0/s1
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128n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236827
PNG
(US9388162, 19)
Show SMILES CC(C)C[C@H](NC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O)C(O)=O
Show InChI InChI=1S/C28H38N2O6/c1-16(2)9-22(26(34)35)29-25(33)11-19-13-28(36)24-10-18-5-6-20(31)12-21(18)27(28,14-23(19)32)7-8-30(24)15-17-3-4-17/h5-6,12,16-17,19,22,24,31,36H,3-4,7-11,13-15H2,1-2H3,(H,29,33)(H,34,35)/t19-,22-,24+,27+,28+/m0/s1
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146n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236823
PNG
(US9388162, 15)
Show SMILES C[C@H](NC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O)C(O)=O
Show InChI InChI=1S/C25H32N2O6/c1-14(23(31)32)26-22(30)9-17-11-25(33)21-8-16-4-5-18(28)10-19(16)24(25,12-20(17)29)6-7-27(21)13-15-2-3-15/h4-5,10,14-15,17,21,28,33H,2-3,6-9,11-13H2,1H3,(H,26,30)(H,31,32)/t14-,17-,21+,24+,25+/m0/s1
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191n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236829
PNG
(US9388162, 48)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CCOCc5ccccc5)C[C@@]34O)c2c1
Show InChI InChI=1S/C30H37NO4/c1-34-25-10-9-23-15-28-30(33)17-24(11-14-35-20-22-5-3-2-4-6-22)27(32)18-29(30,26(23)16-25)12-13-31(28)19-21-7-8-21/h2-6,9-10,16,21,24,28,33H,7-8,11-15,17-20H2,1H3/t24-,28+,29+,30+/m0/s1
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223n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membr...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236839
PNG
(US9388162, 24)
Show SMILES COc1ccc2C[C@@H]3C4[C@@H](O)[C@H](OCc5ccccc5)C(=O)C[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C28H33NO4/c1-32-21-10-9-20-13-23-25-26(31)27(33-17-19-5-3-2-4-6-19)24(30)15-28(25,22(20)14-21)11-12-29(23)16-18-7-8-18/h2-6,9-10,14,18,23,25-27,31H,7-8,11-13,15-17H2,1H3/t23-,25?,26-,27-,28-/m1/s1
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249n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236818
PNG
(US9388162, 8)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CC(O)=O)C[C@@]34O)c2c1
Show InChI InChI=1S/C23H29NO5/c1-29-17-5-4-15-8-20-23(28)11-16(9-21(26)27)19(25)12-22(23,18(15)10-17)6-7-24(20)13-14-2-3-14/h4-5,10,14,16,20,28H,2-3,6-9,11-13H2,1H3,(H,26,27)/t16-,20+,22+,23+/m0/s1
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261n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236830
PNG
(US9388162, 49)
Show SMILES COCC[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(OC)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C24H33NO4/c1-28-10-7-18-13-24(27)22-11-17-5-6-19(29-2)12-20(17)23(24,14-21(18)26)8-9-25(22)15-16-3-4-16/h5-6,12,16,18,22,27H,3-4,7-11,13-15H2,1-2H3/t18-,22+,23+,24+/m0/s1
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324n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236828
PNG
(US9388162, 46)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CCO)C[C@@]34O)c2c1
Show InChI InChI=1S/C23H31NO4/c1-28-18-5-4-16-10-21-23(27)12-17(6-9-25)20(26)13-22(23,19(16)11-18)7-8-24(21)14-15-2-3-15/h4-5,11,15,17,21,25,27H,2-3,6-10,12-14H2,1H3/t17-,21+,22+,23+/m0/s1
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394n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236817
PNG
(US9388162, 1)
Show SMILES CCOC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(OC)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H33NO5/c1-3-31-23(28)11-18-13-25(29)22-10-17-6-7-19(30-2)12-20(17)24(25,14-21(18)27)8-9-26(22)15-16-4-5-16/h6-7,12,16,18,22,29H,3-5,8-11,13-15H2,1-2H3/t18-,22+,24+,25+/m0/s1
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408n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236865
PNG
(US9388162, 72)
Show SMILES COc1ccc2C[C@@H]3[C@@H]4C[C@@H](C(C)C)C(=O)C[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C24H33NO2/c1-15(2)19-12-21-22-10-17-6-7-18(27-3)11-20(17)24(21,13-23(19)26)8-9-25(22)14-16-4-5-16/h6-7,11,15-16,19,21-22H,4-5,8-10,12-14H2,1-3H3/t19-,21-,22+,24+/m0/s1
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476n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membr...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236828
PNG
(US9388162, 46)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CCO)C[C@@]34O)c2c1
Show InChI InChI=1S/C23H31NO4/c1-28-18-5-4-16-10-21-23(27)12-17(6-9-25)20(26)13-22(23,19(16)11-18)7-8-24(21)14-15-2-3-15/h4-5,11,15,17,21,25,27H,2-3,6-10,12-14H2,1H3/t17-,21+,22+,23+/m0/s1
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591n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membr...


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More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236839
PNG
(US9388162, 24)
Show SMILES COc1ccc2C[C@@H]3C4[C@@H](O)[C@H](OCc5ccccc5)C(=O)C[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C28H33NO4/c1-32-21-10-9-20-13-23-25-26(31)27(33-17-19-5-3-2-4-6-19)24(30)15-28(25,22(20)14-21)11-12-29(23)16-18-7-8-18/h2-6,9-10,14,18,23,25-27,31H,7-8,11-13,15-17H2,1H3/t23-,25?,26-,27-,28-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membr...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236830
PNG
(US9388162, 49)
Show SMILES COCC[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(OC)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C24H33NO4/c1-28-10-7-18-13-24(27)22-11-17-5-6-19(29-2)12-20(17)23(24,14-21(18)26)8-9-25(22)15-16-3-4-16/h5-6,12,16,18,22,27H,3-4,7-11,13-15H2,1-2H3/t18-,22+,23+,24+/m0/s1
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1.96E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membr...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236821
PNG
(US9388162, 12)
Show SMILES OC(=O)CC1(CC(O)=O)C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C24H29NO7/c26-16-4-3-15-7-18-24(32)13-22(10-20(28)29,11-21(30)31)19(27)9-23(24,17(15)8-16)5-6-25(18)12-14-1-2-14/h3-4,8,14,18,26,32H,1-2,5-7,9-13H2,(H,28,29)(H,30,31)/t18-,23-,24-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236826
PNG
(US9388162, 18)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CC(=O)N[C@@H](CC(C)C)C(O)=O)C[C@@]34O)c2c1
Show InChI InChI=1S/C29H40N2O6/c1-17(2)10-23(27(34)35)30-26(33)12-20-14-29(36)25-11-19-6-7-21(37-3)13-22(19)28(29,15-24(20)32)8-9-31(25)16-18-4-5-18/h6-7,13,17-18,20,23,25,36H,4-5,8-12,14-16H2,1-3H3,(H,30,33)(H,34,35)/t20-,23-,25+,28+,29+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236820
PNG
(US9388162, 10)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)C(CC(O)=O)(CC(O)=O)C[C@@]34O)c2c1
Show InChI InChI=1S/C25H31NO7/c1-33-17-5-4-16-8-19-25(32)14-23(11-21(28)29,12-22(30)31)20(27)10-24(25,18(16)9-17)6-7-26(19)13-15-2-3-15/h4-5,9,15,19,32H,2-3,6-8,10-14H2,1H3,(H,28,29)(H,30,31)/t19-,24-,25-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236822
PNG
(US9388162, 13)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CC(=O)N[C@@H](C)C(O)=O)C[C@@]34O)c2c1
Show InChI InChI=1S/C26H34N2O6/c1-15(24(31)32)27-23(30)10-18-12-26(33)22-9-17-5-6-19(34-2)11-20(17)25(26,13-21(18)29)7-8-28(22)14-16-3-4-16/h5-6,11,15-16,18,22,33H,3-4,7-10,12-14H2,1-2H3,(H,27,30)(H,31,32)/t15-,18-,22+,25+,26+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236824
PNG
(US9388162, 16)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CC(=O)N5CCC[C@H]5C(O)=O)C[C@@]34O)c2c1
Show InChI InChI=1S/C28H36N2O6/c1-36-20-7-6-18-11-24-28(35)14-19(12-25(32)30-9-2-3-22(30)26(33)34)23(31)15-27(28,21(18)13-20)8-10-29(24)16-17-4-5-17/h6-7,13,17,19,22,24,35H,2-5,8-12,14-16H2,1H3,(H,33,34)/t19-,22-,24+,27+,28+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236822
PNG
(US9388162, 13)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CC(=O)N[C@@H](C)C(O)=O)C[C@@]34O)c2c1
Show InChI InChI=1S/C26H34N2O6/c1-15(24(31)32)27-23(30)10-18-12-26(33)22-9-17-5-6-19(34-2)11-20(17)25(26,13-21(18)29)7-8-28(22)14-16-3-4-16/h5-6,11,15-16,18,22,33H,3-4,7-10,12-14H2,1-2H3,(H,27,30)(H,31,32)/t15-,18-,22+,25+,26+/m0/s1
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n/an/an/an/a 4.60E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236825
PNG
(US9388162, 17)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C27H34N2O6/c30-19-6-5-17-10-23-27(35)13-18(11-24(32)29-8-1-2-21(29)25(33)34)22(31)14-26(27,20(17)12-19)7-9-28(23)15-16-3-4-16/h5-6,12,16,18,21,23,30,35H,1-4,7-11,13-15H2,(H,33,34)/t18-,21-,23+,26+,27+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236857
PNG
(US9388162, 64)
Show SMILES CC(C)CC[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H35NO3/c1-16(2)3-6-19-13-25(29)23-11-18-7-8-20(27)12-21(18)24(25,14-22(19)28)9-10-26(23)15-17-4-5-17/h7-8,12,16-17,19,23,27,29H,3-6,9-11,13-15H2,1-2H3/t19-,23+,24+,25+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236859
PNG
(US9388162, 66)
Show SMILES CCC(C)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H35NO3/c1-3-16(2)10-19-13-25(29)23-11-18-6-7-20(27)12-21(18)24(25,14-22(19)28)8-9-26(23)15-17-4-5-17/h6-7,12,16-17,19,23,27,29H,3-5,8-11,13-15H2,1-2H3/t16?,19-,23+,24+,25+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236865
PNG
(US9388162, 72)
Show SMILES COc1ccc2C[C@@H]3[C@@H]4C[C@@H](C(C)C)C(=O)C[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C24H33NO2/c1-15(2)19-12-21-22-10-17-6-7-18(27-3)11-20(17)24(21,13-23(19)26)8-9-25(22)14-16-4-5-16/h6-7,11,15-16,19,21-22H,4-5,8-10,12-14H2,1-3H3/t19-,21-,22+,24+/m0/s1
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n/an/an/an/a 270n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236819
PNG
(US9388162, 9)
Show SMILES OC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C22H27NO5/c24-16-4-3-14-7-19-22(28)10-15(8-20(26)27)18(25)11-21(22,17(14)9-16)5-6-23(19)12-13-1-2-13/h3-4,9,13,15,19,24,28H,1-2,5-8,10-12H2,(H,26,27)/t15-,19+,21+,22+/m0/s1
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n/an/an/an/a 17.3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236825
PNG
(US9388162, 17)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C27H34N2O6/c30-19-6-5-17-10-23-27(35)13-18(11-24(32)29-8-1-2-21(29)25(33)34)22(31)14-26(27,20(17)12-19)7-9-28(23)15-16-3-4-16/h5-6,12,16,18,21,23,30,35H,1-4,7-11,13-15H2,(H,33,34)/t18-,21-,23+,26+,27+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236829
PNG
(US9388162, 48)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CCOCc5ccccc5)C[C@@]34O)c2c1
Show InChI InChI=1S/C30H37NO4/c1-34-25-10-9-23-15-28-30(33)17-24(11-14-35-20-22-5-3-2-4-6-22)27(32)18-29(30,26(23)16-25)12-13-31(28)19-21-7-8-21/h2-6,9-10,16,21,24,28,33H,7-8,11-15,17-20H2,1H3/t24-,28+,29+,30+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236856
PNG
(US9388162, 62)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)\C(C[C@@]34O)=C\CC(C)C)c2c1
Show InChI InChI=1S/C26H35NO3/c1-17(2)4-7-20-14-26(29)24-12-19-8-9-21(30-3)13-22(19)25(26,15-23(20)28)10-11-27(24)16-18-5-6-18/h7-9,13,17-18,24,29H,4-6,10-12,14-16H2,1-3H3/b20-7+/t24-,25-,26-/m1/s1
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n/an/an/an/a 3.07E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236861
PNG
(US9388162, 68)
Show SMILES CC(C)(C)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H35NO3/c1-23(2,3)12-18-13-25(29)22-10-17-6-7-19(27)11-20(17)24(25,14-21(18)28)8-9-26(22)15-16-4-5-16/h6-7,11,16,18,22,27,29H,4-5,8-10,12-15H2,1-3H3/t18-,22+,24+,25+/m0/s1
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n/an/an/an/a 20.5n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236867
PNG
(US9388162, 74)
Show SMILES CC(C)[C@H]1C[C@H]2[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C23H31NO2/c1-14(2)18-11-20-21-9-16-5-6-17(25)10-19(16)23(20,12-22(18)26)7-8-24(21)13-15-3-4-15/h5-6,10,14-15,18,20-21,25H,3-4,7-9,11-13H2,1-2H3/t18-,20+,21-,23-/m1/s1
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n/an/an/an/a 1.42n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236820
PNG
(US9388162, 10)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)C(CC(O)=O)(CC(O)=O)C[C@@]34O)c2c1
Show InChI InChI=1S/C25H31NO7/c1-33-17-5-4-16-8-19-25(32)14-23(11-21(28)29,12-22(30)31)20(27)10-24(25,18(16)9-17)6-7-26(19)13-15-2-3-15/h4-5,9,15,19,32H,2-3,6-8,10-14H2,1H3,(H,28,29)(H,30,31)/t19-,24-,25-/m1/s1
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n/an/an/an/a 1.47E+4n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236876
PNG
(US9388162, 84)
Show SMILES CN1CC[C@]23CC(=O)[C@@H](CC(=O)NCC4CC4)C[C@@]2(O)[C@H]1Cc1ccc(O)cc31
Show InChI InChI=1S/C23H30N2O4/c1-25-7-6-22-12-19(27)16(9-21(28)24-13-14-2-3-14)11-23(22,29)20(25)8-15-4-5-17(26)10-18(15)22/h4-5,10,14,16,20,26,29H,2-3,6-9,11-13H2,1H3,(H,24,28)/t16-,20+,22+,23+/m0/s1
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n/an/an/an/a 1.26E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236839
PNG
(US9388162, 24)
Show SMILES COc1ccc2C[C@@H]3C4[C@@H](O)[C@H](OCc5ccccc5)C(=O)C[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C28H33NO4/c1-32-21-10-9-20-13-23-25-26(31)27(33-17-19-5-3-2-4-6-19)24(30)15-28(25,22(20)14-21)11-12-29(23)16-18-7-8-18/h2-6,9-10,14,18,23,25-27,31H,7-8,11-13,15-17H2,1H3/t23-,25?,26-,27-,28-/m1/s1
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n/an/an/an/a 463n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236832
PNG
(US9388162, 54)
Show SMILES OCC[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C22H29NO4/c24-8-5-16-11-22(27)20-9-15-3-4-17(25)10-18(15)21(22,12-19(16)26)6-7-23(20)13-14-1-2-14/h3-4,10,14,16,20,24-25,27H,1-2,5-9,11-13H2/t16-,20+,21+,22+/m0/s1
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n/an/an/an/a 1.81n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236867
PNG
(US9388162, 74)
Show SMILES CC(C)[C@H]1C[C@H]2[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C23H31NO2/c1-14(2)18-11-20-21-9-16-5-6-17(25)10-19(16)23(20,12-22(18)26)7-8-24(21)13-15-3-4-15/h5-6,10,14-15,18,20-21,25H,3-4,7-9,11-13H2,1-2H3/t18-,20+,21-,23-/m1/s1
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n/an/an/an/a 3.66n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236829
PNG
(US9388162, 48)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CCOCc5ccccc5)C[C@@]34O)c2c1
Show InChI InChI=1S/C30H37NO4/c1-34-25-10-9-23-15-28-30(33)17-24(11-14-35-20-22-5-3-2-4-6-22)27(32)18-29(30,26(23)16-25)12-13-31(28)19-21-7-8-21/h2-6,9-10,16,21,24,28,33H,7-8,11-15,17-20H2,1H3/t24-,28+,29+,30+/m0/s1
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n/an/an/an/a 362n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236866
PNG
(US9388162, 73)
Show SMILES CC(C)[C@@H]1C[C@H]2[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C23H31NO2/c1-14(2)18-11-20-21-9-16-5-6-17(25)10-19(16)23(20,12-22(18)26)7-8-24(21)13-15-3-4-15/h5-6,10,14-15,18,20-21,25H,3-4,7-9,11-13H2,1-2H3/t18-,20-,21+,23+/m0/s1
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n/an/an/an/a 6.07n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236867
PNG
(US9388162, 74)
Show SMILES CC(C)[C@H]1C[C@H]2[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C23H31NO2/c1-14(2)18-11-20-21-9-16-5-6-17(25)10-19(16)23(20,12-22(18)26)7-8-24(21)13-15-3-4-15/h5-6,10,14-15,18,20-21,25H,3-4,7-9,11-13H2,1-2H3/t18-,20+,21-,23-/m1/s1
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n/an/an/an/a 3.52n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236839
PNG
(US9388162, 24)
Show SMILES COc1ccc2C[C@@H]3C4[C@@H](O)[C@H](OCc5ccccc5)C(=O)C[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C28H33NO4/c1-32-21-10-9-20-13-23-25-26(31)27(33-17-19-5-3-2-4-6-19)24(30)15-28(25,22(20)14-21)11-12-29(23)16-18-7-8-18/h2-6,9-10,14,18,23,25-27,31H,7-8,11-13,15-17H2,1H3/t23-,25?,26-,27-,28-/m1/s1
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n/an/an/an/a 317n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236849
PNG
(US9388162, 34)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@H](C[C@@]34O)NC(=O)C3CC3)c2c1
Show InChI InChI=1S/C24H30N2O4/c27-17-6-5-16-9-21-24(30)11-19(25-22(29)15-3-4-15)20(28)12-23(24,18(16)10-17)7-8-26(21)13-14-1-2-14/h5-6,10,14-15,19,21,27,30H,1-4,7-9,11-13H2,(H,25,29)/t19-,21+,23+,24+/m0/s1
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n/an/an/an/a 12.6n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236866
PNG
(US9388162, 73)
Show SMILES CC(C)[C@@H]1C[C@H]2[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C23H31NO2/c1-14(2)18-11-20-21-9-16-5-6-17(25)10-19(16)23(20,12-22(18)26)7-8-24(21)13-15-3-4-15/h5-6,10,14-15,18,20-21,25H,3-4,7-9,11-13H2,1-2H3/t18-,20-,21+,23+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236818
PNG
(US9388162, 8)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CC(O)=O)C[C@@]34O)c2c1
Show InChI InChI=1S/C23H29NO5/c1-29-17-5-4-15-8-20-23(28)11-16(9-21(26)27)19(25)12-22(23,18(15)10-17)6-7-24(20)13-14-2-3-14/h4-5,10,14,16,20,28H,2-3,6-9,11-13H2,1H3,(H,26,27)/t16-,20+,22+,23+/m0/s1
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n/an/an/an/a 703n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236826
PNG
(US9388162, 18)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CC(=O)N[C@@H](CC(C)C)C(O)=O)C[C@@]34O)c2c1
Show InChI InChI=1S/C29H40N2O6/c1-17(2)10-23(27(34)35)30-26(33)12-20-14-29(36)25-11-19-6-7-21(37-3)13-22(19)28(29,15-24(20)32)8-9-31(25)16-18-4-5-18/h6-7,13,17-18,20,23,25,36H,4-5,8-12,14-16H2,1-3H3,(H,30,33)(H,34,35)/t20-,23-,25+,28+,29+/m0/s1
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n/an/an/an/a 2.75E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236829
PNG
(US9388162, 48)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CCOCc5ccccc5)C[C@@]34O)c2c1
Show InChI InChI=1S/C30H37NO4/c1-34-25-10-9-23-15-28-30(33)17-24(11-14-35-20-22-5-3-2-4-6-22)27(32)18-29(30,26(23)16-25)12-13-31(28)19-21-7-8-21/h2-6,9-10,16,21,24,28,33H,7-8,11-15,17-20H2,1H3/t24-,28+,29+,30+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236875
PNG
(US9388162, 83)
Show SMILES CN1CC[C@]23CC(=O)[C@@H](CC(=O)NCc4ccccc4)C[C@@]2(O)[C@H]1Cc1ccc(O)cc31
Show InChI InChI=1S/C26H30N2O4/c1-28-10-9-25-15-22(30)19(12-24(31)27-16-17-5-3-2-4-6-17)14-26(25,32)23(28)11-18-7-8-20(29)13-21(18)25/h2-8,13,19,23,29,32H,9-12,14-16H2,1H3,(H,27,31)/t19-,23+,25+,26+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236850
PNG
(US9388162, 35)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@H](C[C@@]34O)NC(=O)C3CCCC3)c2c1
Show InChI InChI=1S/C26H34N2O4/c29-19-8-7-18-11-23-26(32)13-21(27-24(31)17-3-1-2-4-17)22(30)14-25(26,20(18)12-19)9-10-28(23)15-16-5-6-16/h7-8,12,16-17,21,23,29,32H,1-6,9-11,13-15H2,(H,27,31)/t21-,23+,25+,26+/m0/s1
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n/an/an/an/a>2.00E+5n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236853
PNG
(US9388162, 38)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@H](C[C@@]34O)NC(=O)C3CCCCC3)c2c1
Show InChI InChI=1S/C27H36N2O4/c30-20-9-8-19-12-24-27(33)14-22(28-25(32)18-4-2-1-3-5-18)23(31)15-26(27,21(19)13-20)10-11-29(24)16-17-6-7-17/h8-9,13,17-18,22,24,30,33H,1-7,10-12,14-16H2,(H,28,32)/t22-,24+,26+,27+/m0/s1
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n/an/an/an/a 10.3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236861
PNG
(US9388162, 68)
Show SMILES CC(C)(C)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H35NO3/c1-23(2,3)12-18-13-25(29)22-10-17-6-7-19(27)11-20(17)24(25,14-21(18)28)8-9-26(22)15-16-4-5-16/h6-7,11,16,18,22,27,29H,4-5,8-10,12-15H2,1-3H3/t18-,22+,24+,25+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236870
PNG
(US9388162, 78)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]4(CC(=O)[C@@H](CC(=O)N5CCC(O)CC5)C[C@@]34O)c2c1
Show InChI InChI=1S/C25H34N2O5/c1-26-10-7-24-15-21(29)17(12-23(30)27-8-5-18(28)6-9-27)14-25(24,31)22(26)11-16-3-4-19(32-2)13-20(16)24/h3-4,13,17-18,22,28,31H,5-12,14-15H2,1-2H3/t17-,22+,24+,25+/m0/s1
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n/an/an/an/a 1.04E+4n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236871
PNG
(US9388162, 79)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]4(CC(=O)[C@@H](CC(=O)N5CCOCC5)C[C@@]34O)c2c1
Show InChI InChI=1S/C24H32N2O5/c1-25-6-5-23-15-20(27)17(12-22(28)26-7-9-31-10-8-26)14-24(23,29)21(25)11-16-3-4-18(30-2)13-19(16)23/h3-4,13,17,21,29H,5-12,14-15H2,1-2H3/t17-,21+,23+,24+/m0/s1
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n/an/an/an/a 1.17E+4n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236873
PNG
(US9388162, 81)
Show SMILES CN1CC[C@]23CC(=O)[C@@H](CC(=O)N4CCC(O)CC4)C[C@@]2(O)[C@H]1Cc1ccc(O)cc31
Show InChI InChI=1S/C24H32N2O5/c1-25-9-6-23-14-20(29)16(11-22(30)26-7-4-17(27)5-8-26)13-24(23,31)21(25)10-15-2-3-18(28)12-19(15)23/h2-3,12,16-17,21,27-28,31H,4-11,13-14H2,1H3/t16-,21+,23+,24+/m0/s1
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n/an/an/an/a 1.01E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236817
PNG
(US9388162, 1)
Show SMILES CCOC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(OC)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H33NO5/c1-3-31-23(28)11-18-13-25(29)22-10-17-6-7-19(30-2)12-20(17)24(25,14-21(18)27)8-9-26(22)15-16-4-5-16/h6-7,12,16,18,22,29H,3-5,8-11,13-15H2,1-2H3/t18-,22+,24+,25+/m0/s1
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n/an/an/an/a 5.11E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236823
PNG
(US9388162, 15)
Show SMILES C[C@H](NC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O)C(O)=O
Show InChI InChI=1S/C25H32N2O6/c1-14(23(31)32)26-22(30)9-17-11-25(33)21-8-16-4-5-18(28)10-19(16)24(25,12-20(17)29)6-7-27(21)13-15-2-3-15/h4-5,10,14-15,17,21,28,33H,2-3,6-9,11-13H2,1H3,(H,26,30)(H,31,32)/t14-,17-,21+,24+,25+/m0/s1
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n/an/an/an/a 221n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236827
PNG
(US9388162, 19)
Show SMILES CC(C)C[C@H](NC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O)C(O)=O
Show InChI InChI=1S/C28H38N2O6/c1-16(2)9-22(26(34)35)29-25(33)11-19-13-28(36)24-10-18-5-6-20(31)12-21(18)27(28,14-23(19)32)7-8-30(24)15-17-3-4-17/h5-6,12,16-17,19,22,24,31,36H,3-4,7-11,13-15H2,1-2H3,(H,29,33)(H,34,35)/t19-,22-,24+,27+,28+/m0/s1
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n/an/an/an/a 201n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236857
PNG
(US9388162, 64)
Show SMILES CC(C)CC[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H35NO3/c1-16(2)3-6-19-13-25(29)23-11-18-7-8-20(27)12-21(18)24(25,14-22(19)28)9-10-26(23)15-17-4-5-17/h7-8,12,16-17,19,23,27,29H,3-6,9-11,13-15H2,1-2H3/t19-,23+,24+,25+/m0/s1
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n/an/an/an/a 4.30n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236844
PNG
(US9388162, 29)
Show SMILES CCC(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C23H30N2O4/c1-2-21(28)24-18-11-23(29)20-9-15-5-6-16(26)10-17(15)22(23,12-19(18)27)7-8-25(20)13-14-3-4-14/h5-6,10,14,18,20,26,29H,2-4,7-9,11-13H2,1H3,(H,24,28)/t18-,20+,22+,23+/m0/s1
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n/an/an/an/a 14.6n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236850
PNG
(US9388162, 35)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@H](C[C@@]34O)NC(=O)C3CCCC3)c2c1
Show InChI InChI=1S/C26H34N2O4/c29-19-8-7-18-11-23-26(32)13-21(27-24(31)17-3-1-2-4-17)22(30)14-25(26,20(18)12-19)9-10-28(23)15-16-5-6-16/h7-8,12,16-17,21,23,29,32H,1-6,9-11,13-15H2,(H,27,31)/t21-,23+,25+,26+/m0/s1
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n/an/an/an/a 13.6n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236833
PNG
(US9388162, 58)
Show SMILES OCC[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(OCc5ccccc5)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C29H35NO4/c31-13-10-23-16-29(33)27-14-22-8-9-24(34-19-21-4-2-1-3-5-21)15-25(22)28(29,17-26(23)32)11-12-30(27)18-20-6-7-20/h1-5,8-9,15,20,23,27,31,33H,6-7,10-14,16-19H2/t23-,27+,28+,29+/m0/s1
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n/an/an/an/a 839n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236858
PNG
(US9388162, 65)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CC5CCCC5)C[C@@]34O)c2c1
Show InChI InChI=1S/C26H35NO3/c28-21-8-7-19-12-24-26(30)14-20(11-17-3-1-2-4-17)23(29)15-25(26,22(19)13-21)9-10-27(24)16-18-5-6-18/h7-8,13,17-18,20,24,28,30H,1-6,9-12,14-16H2/t20-,24+,25+,26+/m0/s1
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n/an/an/an/a 2.57n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236817
PNG
(US9388162, 1)
Show SMILES CCOC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(OC)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H33NO5/c1-3-31-23(28)11-18-13-25(29)22-10-17-6-7-19(30-2)12-20(17)24(25,14-21(18)27)8-9-26(22)15-16-4-5-16/h6-7,12,16,18,22,29H,3-5,8-11,13-15H2,1-2H3/t18-,22+,24+,25+/m0/s1
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n/an/an/an/a 3.40E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236865
PNG
(US9388162, 72)
Show SMILES COc1ccc2C[C@@H]3[C@@H]4C[C@@H](C(C)C)C(=O)C[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C24H33NO2/c1-15(2)19-12-21-22-10-17-6-7-18(27-3)11-20(17)24(21,13-23(19)26)8-9-25(22)14-16-4-5-16/h6-7,11,15-16,19,21-22H,4-5,8-10,12-14H2,1-3H3/t19-,21-,22+,24+/m0/s1
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n/an/an/an/a 212n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236866
PNG
(US9388162, 73)
Show SMILES CC(C)[C@@H]1C[C@H]2[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C23H31NO2/c1-14(2)18-11-20-21-9-16-5-6-17(25)10-19(16)23(20,12-22(18)26)7-8-24(21)13-15-3-4-15/h5-6,10,14-15,18,20-21,25H,3-4,7-9,11-13H2,1-2H3/t18-,20-,21+,23+/m0/s1
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n/an/an/an/a 2.85n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236874
PNG
(US9388162, 82)
Show SMILES CC(C)CNC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3C)CC1=O
Show InChI InChI=1S/C23H32N2O4/c1-14(2)13-24-21(28)9-16-11-23(29)20-8-15-4-5-17(26)10-18(15)22(23,12-19(16)27)6-7-25(20)3/h4-5,10,14,16,20,26,29H,6-9,11-13H2,1-3H3,(H,24,28)/t16-,20+,22+,23+/m0/s1
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n/an/an/an/a 2.33E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236846
PNG
(US9388162, 31)
Show SMILES CC(C)CCCC(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C27H38N2O4/c1-17(2)4-3-5-25(32)28-22-14-27(33)24-12-19-8-9-20(30)13-21(19)26(27,15-23(22)31)10-11-29(24)16-18-6-7-18/h8-9,13,17-18,22,24,30,33H,3-7,10-12,14-16H2,1-2H3,(H,28,32)/t22-,24+,26+,27+/m0/s1
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n/an/an/an/a 9.65n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236851
PNG
(US9388162, 36)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@H](C[C@@]34O)NC(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C27H30N2O4/c30-20-9-8-19-12-24-27(33)14-22(28-25(32)18-4-2-1-3-5-18)23(31)15-26(27,21(19)13-20)10-11-29(24)16-17-6-7-17/h1-5,8-9,13,17,22,24,30,33H,6-7,10-12,14-16H2,(H,28,32)/t22-,24+,26+,27+/m0/s1
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n/an/an/an/a 12.7n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236829
PNG
(US9388162, 48)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CCOCc5ccccc5)C[C@@]34O)c2c1
Show InChI InChI=1S/C30H37NO4/c1-34-25-10-9-23-15-28-30(33)17-24(11-14-35-20-22-5-3-2-4-6-22)27(32)18-29(30,26(23)16-25)12-13-31(28)19-21-7-8-21/h2-6,9-10,16,21,24,28,33H,7-8,11-15,17-20H2,1H3/t24-,28+,29+,30+/m0/s1
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n/an/an/an/a 38.6n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236833
PNG
(US9388162, 58)
Show SMILES OCC[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(OCc5ccccc5)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C29H35NO4/c31-13-10-23-16-29(33)27-14-22-8-9-24(34-19-21-4-2-1-3-5-21)15-25(22)28(29,17-26(23)32)11-12-30(27)18-20-6-7-20/h1-5,8-9,15,20,23,27,31,33H,6-7,10-14,16-19H2/t23-,27+,28+,29+/m0/s1
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n/an/an/an/a 787n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236858
PNG
(US9388162, 65)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CC5CCCC5)C[C@@]34O)c2c1
Show InChI InChI=1S/C26H35NO3/c28-21-8-7-19-12-24-26(30)14-20(11-17-3-1-2-4-17)23(29)15-25(26,22(19)13-21)9-10-27(24)16-18-5-6-18/h7-8,13,17-18,20,24,28,30H,1-6,9-12,14-16H2/t20-,24+,25+,26+/m0/s1
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n/an/an/an/a>2.00E+5n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236869
PNG
(US9388162, 77)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]4(CC(=O)[C@@H](CC(=O)N5CCCC5)C[C@@]34O)c2c1
Show InChI InChI=1S/C24H32N2O4/c1-25-10-7-23-15-20(27)17(12-22(28)26-8-3-4-9-26)14-24(23,29)21(25)11-16-5-6-18(30-2)13-19(16)23/h5-6,13,17,21,29H,3-4,7-12,14-15H2,1-2H3/t17-,21+,23+,24+/m0/s1
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n/an/an/an/a 1.76E+4n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236872
PNG
(US9388162, 80)
Show SMILES CN1CC[C@]23CC(=O)[C@@H](CC(=O)N4CCCCC4)C[C@@]2(O)[C@H]1Cc1ccc(O)cc31
Show InChI InChI=1S/C24H32N2O4/c1-25-10-7-23-15-20(28)17(12-22(29)26-8-3-2-4-9-26)14-24(23,30)21(25)11-16-5-6-18(27)13-19(16)23/h5-6,13,17,21,27,30H,2-4,7-12,14-15H2,1H3/t17-,21+,23+,24+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236832
PNG
(US9388162, 54)
Show SMILES OCC[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C22H29NO4/c24-8-5-16-11-22(27)20-9-15-3-4-17(25)10-18(15)21(22,12-19(16)26)6-7-23(20)13-14-1-2-14/h3-4,10,14,16,20,24-25,27H,1-2,5-9,11-13H2/t16-,20+,21+,22+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236851
PNG
(US9388162, 36)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@H](C[C@@]34O)NC(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C27H30N2O4/c30-20-9-8-19-12-24-27(33)14-22(28-25(32)18-4-2-1-3-5-18)23(31)15-26(27,21(19)13-20)10-11-29(24)16-17-6-7-17/h1-5,8-9,13,17,22,24,30,33H,6-7,10-12,14-16H2,(H,28,32)/t22-,24+,26+,27+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236853
PNG
(US9388162, 38)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@H](C[C@@]34O)NC(=O)C3CCCCC3)c2c1
Show InChI InChI=1S/C27H36N2O4/c30-20-9-8-19-12-24-27(33)14-22(28-25(32)18-4-2-1-3-5-18)23(31)15-26(27,21(19)13-20)10-11-29(24)16-17-6-7-17/h8-9,13,17-18,22,24,30,33H,1-7,10-12,14-16H2,(H,28,32)/t22-,24+,26+,27+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236832
PNG
(US9388162, 54)
Show SMILES OCC[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C22H29NO4/c24-8-5-16-11-22(27)20-9-15-3-4-17(25)10-18(15)21(22,12-19(16)26)6-7-23(20)13-14-1-2-14/h3-4,10,14,16,20,24-25,27H,1-2,5-9,11-13H2/t16-,20+,21+,22+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236857
PNG
(US9388162, 64)
Show SMILES CC(C)CC[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H35NO3/c1-16(2)3-6-19-13-25(29)23-11-18-7-8-20(27)12-21(18)24(25,14-22(19)28)9-10-26(23)15-17-4-5-17/h7-8,12,16-17,19,23,27,29H,3-6,9-11,13-15H2,1-2H3/t19-,23+,24+,25+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236859
PNG
(US9388162, 66)
Show SMILES CCC(C)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H35NO3/c1-3-16(2)10-19-13-25(29)23-11-18-6-7-20(27)12-21(18)24(25,14-22(19)28)8-9-26(23)15-17-4-5-17/h6-7,12,16-17,19,23,27,29H,3-5,8-11,13-15H2,1-2H3/t16?,19-,23+,24+,25+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236862
PNG
(US9388162, 69)
Show SMILES CC(C)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C24H33NO3/c1-15(2)9-18-12-24(28)22-10-17-5-6-19(26)11-20(17)23(24,13-21(18)27)7-8-25(22)14-16-3-4-16/h5-6,11,15-16,18,22,26,28H,3-4,7-10,12-14H2,1-2H3/t18-,22+,23+,24+/m0/s1
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n/an/an/an/a 9.52n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236864
PNG
(US9388162, 71)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](Cc5ccccc5)C[C@@]34O)c2c1
Show InChI InChI=1S/C27H31NO3/c29-22-9-8-20-13-25-27(31)15-21(12-18-4-2-1-3-5-18)24(30)16-26(27,23(20)14-22)10-11-28(25)17-19-6-7-19/h1-5,8-9,14,19,21,25,29,31H,6-7,10-13,15-17H2/t21-,25+,26+,27+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236865
PNG
(US9388162, 72)
Show SMILES COc1ccc2C[C@@H]3[C@@H]4C[C@@H](C(C)C)C(=O)C[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C24H33NO2/c1-15(2)19-12-21-22-10-17-6-7-18(27-3)11-20(17)24(21,13-23(19)26)8-9-25(22)14-16-4-5-16/h6-7,11,15-16,19,21-22H,4-5,8-10,12-14H2,1-3H3/t19-,21-,22+,24+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236869
PNG
(US9388162, 77)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]4(CC(=O)[C@@H](CC(=O)N5CCCC5)C[C@@]34O)c2c1
Show InChI InChI=1S/C24H32N2O4/c1-25-10-7-23-15-20(27)17(12-22(28)26-8-3-4-9-26)14-24(23,29)21(25)11-16-5-6-18(30-2)13-19(16)23/h5-6,13,17,21,29H,3-4,7-12,14-15H2,1-2H3/t17-,21+,23+,24+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236855
PNG
(US9388162, 43)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@H](C[C@@]34O)NS(=O)(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C26H30N2O5S/c29-19-9-8-18-12-24-26(31)14-22(27-34(32,33)20-4-2-1-3-5-20)23(30)15-25(26,21(18)13-19)10-11-28(24)16-17-6-7-17/h1-5,8-9,13,17,22,24,27,29,31H,6-7,10-12,14-16H2/t22-,24+,25+,26+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236832
PNG
(US9388162, 54)
Show SMILES OCC[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C22H29NO4/c24-8-5-16-11-22(27)20-9-15-3-4-17(25)10-18(15)21(22,12-19(16)26)6-7-23(20)13-14-1-2-14/h3-4,10,14,16,20,24-25,27H,1-2,5-9,11-13H2/t16-,20+,21+,22+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236867
PNG
(US9388162, 74)
Show SMILES CC(C)[C@H]1C[C@H]2[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C23H31NO2/c1-14(2)18-11-20-21-9-16-5-6-17(25)10-19(16)23(20,12-22(18)26)7-8-24(21)13-15-3-4-15/h5-6,10,14-15,18,20-21,25H,3-4,7-9,11-13H2,1-2H3/t18-,20+,21-,23-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236838
PNG
(US9388162, 23)
Show SMILES COc1ccc2C[C@@H]3C4C[C@H](OCC(C)C)C(=O)C[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C25H35NO3/c1-16(2)15-29-24-12-21-22-10-18-6-7-19(28-3)11-20(18)25(21,13-23(24)27)8-9-26(22)14-17-4-5-17/h6-7,11,16-17,21-22,24H,4-5,8-10,12-15H2,1-3H3/t21?,22-,24+,25-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236848
PNG
(US9388162, 33)
Show SMILES CC(C)CC(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H34N2O4/c1-15(2)9-23(30)26-20-12-25(31)22-10-17-5-6-18(28)11-19(17)24(25,13-21(20)29)7-8-27(22)14-16-3-4-16/h5-6,11,15-16,20,22,28,31H,3-4,7-10,12-14H2,1-2H3,(H,26,30)/t20-,22+,24+,25+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236834
PNG
(US9388162, 59)
Show SMILES CCOC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(OC)cc4[C@@]2(CCN3C)CC1=O
Show InChI InChI=1S/C22H29NO5/c1-4-28-20(25)10-15-12-22(26)19-9-14-5-6-16(27-3)11-17(14)21(22,13-18(15)24)7-8-23(19)2/h5-6,11,15,19,26H,4,7-10,12-13H2,1-3H3/t15-,19+,21+,22+/m0/s1
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n/an/an/an/a 1.15E+4n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236863
PNG
(US9388162, 70)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CC5CCCCC5)C[C@@]34O)c2c1
Show InChI InChI=1S/C27H37NO3/c29-22-9-8-20-13-25-27(31)15-21(12-18-4-2-1-3-5-18)24(30)16-26(27,23(20)14-22)10-11-28(25)17-19-6-7-19/h8-9,14,18-19,21,25,29,31H,1-7,10-13,15-17H2/t21-,25+,26+,27+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236818
PNG
(US9388162, 8)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CC(O)=O)C[C@@]34O)c2c1
Show InChI InChI=1S/C23H29NO5/c1-29-17-5-4-15-8-20-23(28)11-16(9-21(26)27)19(25)12-22(23,18(15)10-17)6-7-24(20)13-14-2-3-14/h4-5,10,14,16,20,28H,2-3,6-9,11-13H2,1H3,(H,26,27)/t16-,20+,22+,23+/m0/s1
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n/an/an/an/a 4.44E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236838
PNG
(US9388162, 23)
Show SMILES COc1ccc2C[C@@H]3C4C[C@H](OCC(C)C)C(=O)C[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C25H35NO3/c1-16(2)15-29-24-12-21-22-10-18-6-7-19(28-3)11-20(18)25(21,13-23(24)27)8-9-26(22)14-17-4-5-17/h6-7,11,16-17,21-22,24H,4-5,8-10,12-15H2,1-3H3/t21?,22-,24+,25-/m1/s1
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n/an/an/an/a 5.56E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236842
PNG
(US9388162, 27)
Show SMILES CC(C)C(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C24H32N2O4/c1-14(2)22(29)25-19-11-24(30)21-9-16-5-6-17(27)10-18(16)23(24,12-20(19)28)7-8-26(21)13-15-3-4-15/h5-6,10,14-15,19,21,27,30H,3-4,7-9,11-13H2,1-2H3,(H,25,29)/t19-,21+,23+,24+/m0/s1
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n/an/an/an/a 24.7n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236843
PNG
(US9388162, 28)
Show SMILES CC(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C22H28N2O4/c1-13(25)23-18-10-22(28)20-8-15-4-5-16(26)9-17(15)21(22,11-19(18)27)6-7-24(20)12-14-2-3-14/h4-5,9,14,18,20,26,28H,2-3,6-8,10-12H2,1H3,(H,23,25)/t18-,20+,21+,22+/m0/s1
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n/an/an/an/a 27.1n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236848
PNG
(US9388162, 33)
Show SMILES CC(C)CC(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H34N2O4/c1-15(2)9-23(30)26-20-12-25(31)22-10-17-5-6-18(28)11-19(17)24(25,13-21(20)29)7-8-27(22)14-16-3-4-16/h5-6,11,15-16,20,22,28,31H,3-4,7-10,12-14H2,1-2H3,(H,26,30)/t20-,22+,24+,25+/m0/s1
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n/an/an/an/a 36.1n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236831
PNG
(US9388162, 50)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]4(CC(=O)[C@@H](CCOCc5ccccc5)C[C@@]34O)c2c1
Show InChI InChI=1S/C27H33NO4/c1-28-12-11-26-17-24(29)21(10-13-32-18-19-6-4-3-5-7-19)16-27(26,30)25(28)14-20-8-9-22(31-2)15-23(20)26/h3-9,15,21,25,30H,10-14,16-18H2,1-2H3/t21-,25+,26+,27+/m0/s1
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n/an/an/an/a 7.90E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236835
PNG
(US9388162, 60)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]4(CC(=O)[C@@H](CC(O)=O)C[C@@]34O)c2c1
Show InChI InChI=1S/C20H25NO5/c1-21-6-5-19-11-16(22)13(8-18(23)24)10-20(19,25)17(21)7-12-3-4-14(26-2)9-15(12)19/h3-4,9,13,17,25H,5-8,10-11H2,1-2H3,(H,23,24)/t13-,17+,19+,20+/m0/s1
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n/an/an/an/a 1.49E+4n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236860
PNG
(US9388162, 67)
Show SMILES CCCC[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C24H33NO3/c1-2-3-4-18-13-24(28)22-11-17-7-8-19(26)12-20(17)23(24,14-21(18)27)9-10-25(22)15-16-5-6-16/h7-8,12,16,18,22,26,28H,2-6,9-11,13-15H2,1H3/t18-,22+,23+,24+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236819
PNG
(US9388162, 9)
Show SMILES OC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C22H27NO5/c24-16-4-3-14-7-19-22(28)10-15(8-20(26)27)18(25)11-21(22,17(14)9-16)5-6-23(19)12-13-1-2-13/h3-4,9,13,15,19,24,28H,1-2,5-8,10-12H2,(H,26,27)/t15-,19+,21+,22+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236824
PNG
(US9388162, 16)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CC(=O)N5CCC[C@H]5C(O)=O)C[C@@]34O)c2c1
Show InChI InChI=1S/C28H36N2O6/c1-36-20-7-6-18-11-24-28(35)14-19(12-25(32)30-9-2-3-22(30)26(33)34)23(31)15-27(28,21(18)13-20)8-10-29(24)16-17-4-5-17/h6-7,13,17,19,22,24,35H,2-5,8-12,14-16H2,1H3,(H,33,34)/t19-,22-,24+,27+,28+/m0/s1
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n/an/an/an/a 6.77E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236827
PNG
(US9388162, 19)
Show SMILES CC(C)C[C@H](NC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O)C(O)=O
Show InChI InChI=1S/C28H38N2O6/c1-16(2)9-22(26(34)35)29-25(33)11-19-13-28(36)24-10-18-5-6-20(31)12-21(18)27(28,14-23(19)32)7-8-30(24)15-17-3-4-17/h5-6,12,16-17,19,22,24,31,36H,3-4,7-11,13-15H2,1-2H3,(H,29,33)(H,34,35)/t19-,22-,24+,27+,28+/m0/s1
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n/an/an/an/a 49.7n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236847
PNG
(US9388162, 32)
Show SMILES CC(C)(C)C(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H34N2O4/c1-23(2,3)22(30)26-19-12-25(31)21-10-16-6-7-17(28)11-18(16)24(25,13-20(19)29)8-9-27(21)14-15-4-5-15/h6-7,11,15,19,21,28,31H,4-5,8-10,12-14H2,1-3H3,(H,26,30)/t19-,21+,24+,25+/m0/s1
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n/an/an/an/a 18.6n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236849
PNG
(US9388162, 34)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@H](C[C@@]34O)NC(=O)C3CC3)c2c1
Show InChI InChI=1S/C24H30N2O4/c27-17-6-5-16-9-21-24(30)11-19(25-22(29)15-3-4-15)20(28)12-23(24,18(16)10-17)7-8-26(21)13-14-1-2-14/h5-6,10,14-15,19,21,27,30H,1-4,7-9,11-13H2,(H,25,29)/t19-,21+,23+,24+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236852
PNG
(US9388162, 37)
Show SMILES CC[C@H](C)C(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H34N2O4/c1-3-15(2)23(30)26-20-12-25(31)22-10-17-6-7-18(28)11-19(17)24(25,13-21(20)29)8-9-27(22)14-16-4-5-16/h6-7,11,15-16,20,22,28,31H,3-5,8-10,12-14H2,1-2H3,(H,26,30)/t15-,20-,22+,24+,25+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236831
PNG
(US9388162, 50)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]4(CC(=O)[C@@H](CCOCc5ccccc5)C[C@@]34O)c2c1
Show InChI InChI=1S/C27H33NO4/c1-28-12-11-26-17-24(29)21(10-13-32-18-19-6-4-3-5-7-19)16-27(26,30)25(28)14-20-8-9-22(31-2)15-23(20)26/h3-9,15,21,25,30H,10-14,16-18H2,1-2H3/t21-,25+,26+,27+/m0/s1
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n/an/an/an/a 148n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236856
PNG
(US9388162, 62)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)\C(C[C@@]34O)=C\CC(C)C)c2c1
Show InChI InChI=1S/C26H35NO3/c1-17(2)4-7-20-14-26(29)24-12-19-8-9-21(30-3)13-22(19)25(26,15-23(20)28)10-11-27(24)16-18-5-6-18/h7-9,13,17-18,24,29H,4-6,10-12,14-16H2,1-3H3/b20-7+/t24-,25-,26-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236860
PNG
(US9388162, 67)
Show SMILES CCCC[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C24H33NO3/c1-2-3-4-18-13-24(28)22-11-17-7-8-19(26)12-20(17)23(24,14-21(18)27)9-10-25(22)15-16-5-6-16/h7-8,12,16,18,22,26,28H,2-6,9-11,13-15H2,1H3/t18-,22+,23+,24+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236864
PNG
(US9388162, 71)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](Cc5ccccc5)C[C@@]34O)c2c1
Show InChI InChI=1S/C27H31NO3/c29-22-9-8-20-13-25-27(31)15-21(12-18-4-2-1-3-5-18)24(30)16-26(27,23(20)14-22)10-11-28(25)17-19-6-7-19/h1-5,8-9,14,19,21,25,29,31H,6-7,10-13,15-17H2/t21-,25+,26+,27+/m0/s1
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n/an/an/an/a 6.76n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236845
PNG
(US9388162, 30)
Show SMILES CC(C)CCC(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C26H36N2O4/c1-16(2)3-8-24(31)27-21-13-26(32)23-11-18-6-7-19(29)12-20(18)25(26,14-22(21)30)9-10-28(23)15-17-4-5-17/h6-7,12,16-17,21,23,29,32H,3-5,8-11,13-15H2,1-2H3,(H,27,31)/t21-,23+,25+,26+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236846
PNG
(US9388162, 31)
Show SMILES CC(C)CCCC(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C27H38N2O4/c1-17(2)4-3-5-25(32)28-22-14-27(33)24-12-19-8-9-20(30)13-21(19)26(27,15-23(22)31)10-11-29(24)16-18-6-7-18/h8-9,13,17-18,22,24,30,33H,3-7,10-12,14-16H2,1-2H3,(H,28,32)/t22-,24+,26+,27+/m0/s1
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n/an/an/an/a 2.59n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236847
PNG
(US9388162, 32)
Show SMILES CC(C)(C)C(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H34N2O4/c1-23(2,3)22(30)26-19-12-25(31)21-10-16-6-7-17(28)11-18(16)24(25,13-20(19)29)8-9-27(21)14-15-4-5-15/h6-7,11,15,19,21,28,31H,4-5,8-10,12-14H2,1-3H3,(H,26,30)/t19-,21+,24+,25+/m0/s1
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n/an/an/an/a 17.5n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236852
PNG
(US9388162, 37)
Show SMILES CC[C@H](C)C(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H34N2O4/c1-3-15(2)23(30)26-20-12-25(31)22-10-17-6-7-18(28)11-19(17)24(25,13-21(20)29)8-9-27(22)14-16-4-5-16/h6-7,11,15-16,20,22,28,31H,3-5,8-10,12-14H2,1-2H3,(H,26,30)/t15-,20-,22+,24+,25+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236837
PNG
(US9388162, 75)
Show SMILES C[C@H](NC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3C)CC1=O)C(O)=O
Show InChI InChI=1S/C22H28N2O6/c1-12(20(28)29)23-19(27)8-14-10-22(30)18-7-13-3-4-15(25)9-16(13)21(22,11-17(14)26)5-6-24(18)2/h3-4,9,12,14,18,25,30H,5-8,10-11H2,1-2H3,(H,23,27)(H,28,29)/t12-,14-,18+,21+,22+/m0/s1
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UniChem
US Patent
n/an/an/an/a 1.66E+4n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236823
PNG
(US9388162, 15)
Show SMILES C[C@H](NC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O)C(O)=O
Show InChI InChI=1S/C25H32N2O6/c1-14(23(31)32)26-22(30)9-17-11-25(33)21-8-16-4-5-18(28)10-19(16)24(25,12-20(17)29)6-7-27(21)13-15-2-3-15/h4-5,10,14-15,17,21,28,33H,2-3,6-9,11-13H2,1H3,(H,26,30)(H,31,32)/t14-,17-,21+,24+,25+/m0/s1
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n/an/an/an/a 43.8n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236854
PNG
(US9388162, 42)
Show SMILES CCS(=O)(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C22H30N2O5S/c1-2-30(28,29)23-18-11-22(27)20-9-15-5-6-16(25)10-17(15)21(22,12-19(18)26)7-8-24(20)13-14-3-4-14/h5-6,10,14,18,20,23,25,27H,2-4,7-9,11-13H2,1H3/t18-,20+,21+,22+/m0/s1
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n/an/an/an/a>2.00E+5n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236857
PNG
(US9388162, 64)
Show SMILES CC(C)CC[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C25H35NO3/c1-16(2)3-6-19-13-25(29)23-11-18-7-8-20(27)12-21(18)24(25,14-22(19)28)9-10-26(23)15-17-4-5-17/h7-8,12,16-17,19,23,27,29H,3-6,9-11,13-15H2,1-2H3/t19-,23+,24+,25+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236842
PNG
(US9388162, 27)
Show SMILES CC(C)C(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C24H32N2O4/c1-14(2)22(29)25-19-11-24(30)21-9-16-5-6-17(27)10-18(16)23(24,12-20(19)28)7-8-26(21)13-15-3-4-15/h5-6,10,14-15,19,21,27,30H,3-4,7-9,11-13H2,1-2H3,(H,25,29)/t19-,21+,23+,24+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236843
PNG
(US9388162, 28)
Show SMILES CC(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C22H28N2O4/c1-13(25)23-18-10-22(28)20-8-15-4-5-16(26)9-17(15)21(22,11-19(18)27)6-7-24(20)12-14-2-3-14/h4-5,9,14,18,20,26,28H,2-3,6-8,10-12H2,1H3,(H,23,25)/t18-,20+,21+,22+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236845
PNG
(US9388162, 30)
Show SMILES CC(C)CCC(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C26H36N2O4/c1-16(2)3-8-24(31)27-21-13-26(32)23-11-18-6-7-19(29)12-20(18)25(26,14-22(21)30)9-10-28(23)15-17-4-5-17/h6-7,12,16-17,21,23,29,32H,3-5,8-11,13-15H2,1-2H3,(H,27,31)/t21-,23+,25+,26+/m0/s1
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n/an/an/an/a 9.61n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236828
PNG
(US9388162, 46)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CCO)C[C@@]34O)c2c1
Show InChI InChI=1S/C23H31NO4/c1-28-18-5-4-16-10-21-23(27)12-17(6-9-25)20(26)13-22(23,19(16)11-18)7-8-24(21)14-15-2-3-15/h4-5,11,15,17,21,25,27H,2-3,6-10,12-14H2,1H3/t17-,21+,22+,23+/m0/s1
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n/an/an/an/a 409n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236836
PNG
(US9388162, 61)
Show SMILES CN1CC[C@]23CC(=O)[C@@H](CC(O)=O)C[C@@]2(O)[C@H]1Cc1ccc(O)cc31
Show InChI InChI=1S/C19H23NO5/c1-20-5-4-18-10-15(22)12(7-17(23)24)9-19(18,25)16(20)6-11-2-3-13(21)8-14(11)18/h2-3,8,12,16,21,25H,4-7,9-10H2,1H3,(H,23,24)/t12-,16+,18+,19+/m0/s1
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n/an/an/an/a 466n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236866
PNG
(US9388162, 73)
Show SMILES CC(C)[C@@H]1C[C@H]2[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C23H31NO2/c1-14(2)18-11-20-21-9-16-5-6-17(25)10-19(16)23(20,12-22(18)26)7-8-24(21)13-15-3-4-15/h5-6,10,14-15,18,20-21,25H,3-4,7-9,11-13H2,1-2H3/t18-,20-,21+,23+/m0/s1
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n/an/an/an/a 0.840n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236865
PNG
(US9388162, 72)
Show SMILES COc1ccc2C[C@@H]3[C@@H]4C[C@@H](C(C)C)C(=O)C[C@]4(CCN3CC3CC3)c2c1
Show InChI InChI=1S/C24H33NO2/c1-15(2)19-12-21-22-10-17-6-7-18(27-3)11-20(17)24(21,13-23(19)26)8-9-25(22)14-16-4-5-16/h6-7,11,15-16,19,21-22H,4-5,8-10,12-14H2,1-3H3/t19-,21-,22+,24+/m0/s1
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n/an/an/an/a 1.05E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236840
PNG
(US9388162, 25)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](O)C[C@@]34O)c2c1
Show InChI InChI=1S/C21H27NO4/c1-26-15-5-4-14-8-19-21(25)11-18(24)17(23)10-20(21,16(14)9-15)6-7-22(19)12-13-2-3-13/h4-5,9,13,18-19,24-25H,2-3,6-8,10-12H2,1H3/t18-,19+,20+,21+/m0/s1
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n/an/an/an/a 877n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236841
PNG
(US9388162, 26)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@H](C[C@@]34O)NC(=O)C(C)C)c2c1
Show InChI InChI=1S/C25H34N2O4/c1-15(2)23(29)26-20-12-25(30)22-10-17-6-7-18(31-3)11-19(17)24(25,13-21(20)28)8-9-27(22)14-16-4-5-16/h6-7,11,15-16,20,22,30H,4-5,8-10,12-14H2,1-3H3,(H,26,29)/t20-,22+,24+,25+/m0/s1
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n/an/an/an/a 7.21E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236828
PNG
(US9388162, 46)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CCO)C[C@@]34O)c2c1
Show InChI InChI=1S/C23H31NO4/c1-28-18-5-4-16-10-21-23(27)12-17(6-9-25)20(26)13-22(23,19(16)11-18)7-8-24(21)14-15-2-3-15/h4-5,11,15,17,21,25,27H,2-3,6-10,12-14H2,1H3/t17-,21+,22+,23+/m0/s1
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n/an/an/an/a 1.02E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236830
PNG
(US9388162, 49)
Show SMILES COCC[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(OC)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C24H33NO4/c1-28-10-7-18-13-24(27)22-11-17-5-6-19(29-2)12-20(17)23(24,14-21(18)26)8-9-25(22)15-16-3-4-16/h5-6,12,16,18,22,27H,3-4,7-11,13-15H2,1-2H3/t18-,22+,23+,24+/m0/s1
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n/an/an/an/a 1.28E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236834
PNG
(US9388162, 59)
Show SMILES CCOC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(OC)cc4[C@@]2(CCN3C)CC1=O
Show InChI InChI=1S/C22H29NO5/c1-4-28-20(25)10-15-12-22(26)19-9-14-5-6-16(27-3)11-17(14)21(22,13-18(15)24)7-8-23(19)2/h5-6,11,15,19,26H,4,7-10,12-13H2,1-3H3/t15-,19+,21+,22+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236871
PNG
(US9388162, 79)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]4(CC(=O)[C@@H](CC(=O)N5CCOCC5)C[C@@]34O)c2c1
Show InChI InChI=1S/C24H32N2O5/c1-25-6-5-23-15-20(27)17(12-22(28)26-7-9-31-10-8-26)14-24(23,29)21(25)11-16-3-4-18(30-2)13-19(16)23/h3-4,13,17,21,29H,5-12,14-15H2,1-2H3/t17-,21+,23+,24+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236872
PNG
(US9388162, 80)
Show SMILES CN1CC[C@]23CC(=O)[C@@H](CC(=O)N4CCCCC4)C[C@@]2(O)[C@H]1Cc1ccc(O)cc31
Show InChI InChI=1S/C24H32N2O4/c1-25-10-7-23-15-20(28)17(12-22(29)26-8-3-2-4-9-26)14-24(23,30)21(25)11-16-5-6-18(27)13-19(16)23/h5-6,13,17,21,27,30H,2-4,7-12,14-15H2,1H3/t17-,21+,23+,24+/m0/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236821
PNG
(US9388162, 12)
Show SMILES OC(=O)CC1(CC(O)=O)C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C24H29NO7/c26-16-4-3-15-7-18-24(32)13-22(10-20(28)29,11-21(30)31)19(27)9-23(24,17(15)8-16)5-6-25(18)12-14-1-2-14/h3-4,8,14,18,26,32H,1-2,5-7,9-13H2,(H,28,29)(H,30,31)/t18-,23-,24-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236840
PNG
(US9388162, 25)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](O)C[C@@]34O)c2c1
Show InChI InChI=1S/C21H27NO4/c1-26-15-5-4-14-8-19-21(25)11-18(24)17(23)10-20(21,16(14)9-15)6-7-22(19)12-13-2-3-13/h4-5,9,13,18-19,24-25H,2-3,6-8,10-12H2,1H3/t18-,19+,20+,21+/m0/s1
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n/an/an/an/a 578n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236841
PNG
(US9388162, 26)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@H](C[C@@]34O)NC(=O)C(C)C)c2c1
Show InChI InChI=1S/C25H34N2O4/c1-15(2)23(29)26-20-12-25(30)22-10-17-6-7-18(31-3)11-19(17)24(25,13-21(20)28)8-9-27(22)14-16-4-5-16/h6-7,11,15-16,20,22,30H,4-5,8-10,12-14H2,1-3H3,(H,26,29)/t20-,22+,24+,25+/m0/s1
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n/an/an/an/a 7.11E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236844
PNG
(US9388162, 29)
Show SMILES CCC(=O)N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C23H30N2O4/c1-2-21(28)24-18-11-23(29)20-9-15-5-6-16(26)10-17(15)22(23,12-19(18)27)7-8-25(20)13-14-3-4-14/h5-6,10,14,18,20,26,29H,2-4,7-9,11-13H2,1H3,(H,24,28)/t18-,20+,22+,23+/m0/s1
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UniChem
US Patent
n/an/an/an/a>2.00E+5n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236862
PNG
(US9388162, 69)
Show SMILES CC(C)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CC1=O
Show InChI InChI=1S/C24H33NO3/c1-15(2)9-18-12-24(28)22-10-17-5-6-19(26)11-20(17)23(24,13-21(18)27)7-8-25(22)14-16-3-4-16/h5-6,11,15-16,18,22,26,28H,3-4,7-10,12-14H2,1-2H3/t18-,22+,23+,24+/m0/s1
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US Patent
n/an/an/an/a>2.00E+5n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236837
PNG
(US9388162, 75)
Show SMILES C[C@H](NC(=O)C[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3C)CC1=O)C(O)=O
Show InChI InChI=1S/C22H28N2O6/c1-12(20(28)29)23-19(27)8-14-10-22(30)18-7-13-3-4-15(25)9-16(13)21(22,11-17(14)26)5-6-24(18)2/h3-4,9,12,14,18,25,30H,5-8,10-11H2,1-2H3,(H,23,27)(H,28,29)/t12-,14-,18+,21+,22+/m0/s1
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US Patent
n/an/an/an/a 1.15E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM236868
PNG
(US9388162, 76)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]4(CC(=O)[C@@H](CC(=O)N5CCCCC5)C[C@@]34O)c2c1
Show InChI InChI=1S/C25H34N2O4/c1-26-11-8-24-16-21(28)18(13-23(29)27-9-4-3-5-10-27)15-25(24,30)22(26)12-17-6-7-19(31-2)14-20(17)24/h6-7,14,18,22,30H,3-5,8-13,15-16H2,1-2H3/t18-,22+,24+,25+/m0/s1
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US Patent
n/an/an/an/a 1.67E+4n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
[35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared from a cell line expressing recombinant μ ...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236836
PNG
(US9388162, 61)
Show SMILES CN1CC[C@]23CC(=O)[C@@H](CC(O)=O)C[C@@]2(O)[C@H]1Cc1ccc(O)cc31
Show InChI InChI=1S/C19H23NO5/c1-20-5-4-18-10-15(22)12(7-17(23)24)9-19(18,25)16(20)6-11-2-3-13(21)8-14(11)18/h2-3,8,12,16,21,25H,4-7,9-10H2,1H3,(H,23,24)/t12-,16+,18+,19+/m0/s1
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US Patent
n/an/an/an/a 963n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236863
PNG
(US9388162, 70)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)[C@@H](CC5CCCCC5)C[C@@]34O)c2c1
Show InChI InChI=1S/C27H37NO3/c29-22-9-8-20-13-25-27(31)15-21(12-18-4-2-1-3-5-18)24(30)16-26(27,23(20)14-22)10-11-28(25)17-19-6-7-19/h8-9,14,18-19,21,25,29,31H,1-7,10-13,15-17H2/t21-,25+,26+,27+/m0/s1
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US Patent
n/an/an/an/a 4.01n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236868
PNG
(US9388162, 76)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]4(CC(=O)[C@@H](CC(=O)N5CCCCC5)C[C@@]34O)c2c1
Show InChI InChI=1S/C25H34N2O4/c1-26-11-8-24-16-21(28)18(13-23(29)27-9-4-3-5-10-27)15-25(24,30)22(26)12-17-6-7-19(31-2)14-20(17)24/h6-7,14,18,22,30H,3-5,8-13,15-16H2,1-2H3/t18-,22+,24+,25+/m0/s1
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US Patent
n/an/an/an/a>2.00E+5n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236870
PNG
(US9388162, 78)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]4(CC(=O)[C@@H](CC(=O)N5CCC(O)CC5)C[C@@]34O)c2c1
Show InChI InChI=1S/C25H34N2O5/c1-26-10-7-24-15-21(29)17(12-23(30)27-8-5-18(28)6-9-27)14-25(24,31)22(26)11-16-3-4-19(32-2)13-20(16)24/h3-4,13,17-18,22,28,31H,5-12,14-15H2,1-2H3/t17-,22+,24+,25+/m0/s1
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n/an/an/an/a>2.00E+5n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM236873
PNG
(US9388162, 81)
Show SMILES CN1CC[C@]23CC(=O)[C@@H](CC(=O)N4CCC(O)CC4)C[C@@]2(O)[C@H]1Cc1ccc(O)cc31
Show InChI InChI=1S/C24H32N2O5/c1-25-9-6-23-14-20(29)16(11-22(30)26-7-4-17(27)5-8-26)13-24(23,31)21(25)10-15-2-3-18(28)12-19(15)23/h2-3,12,16-17,21,27-28,31H,4-11,13-14H2,1H3/t16-,21+,23+,24+/m0/s1
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US Patent
n/an/an/an/a 6.51E+3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%