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Patent code US9388165

Compile Data Set for Download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D)


(Homo sapiens (Human))
BDBM238347
PNG
(US9388165, 3)
Show SMILES Cc1ccc(cc1NC(=O)c1cccc2c(N)nccc12)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-15(23(33)31-17-5-2-4-16(13-17)25(26,27)28)12-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
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n/an/a 2.80n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D)


(Homo sapiens (Human))
BDBM238345
PNG
(US9388165, 1)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
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n/an/a 6.10n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D)


(Homo sapiens (Human))
BDBM238349
PNG
(US9388165, 6)
Show SMILES CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(NC(=O)c4cccc5c(NC(C)(C)C)nccc45)c3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C36H41F3N6O2/c1-6-44-16-18-45(19-17-44)22-25-12-13-26(21-30(25)36(37,38)39)41-33(46)24-11-10-23(2)31(20-24)42-34(47)29-9-7-8-28-27(29)14-15-40-32(28)43-35(3,4)5/h7-15,20-21H,6,16-19,22H2,1-5H3,(H,40,43)(H,41,46)(H,42,47)
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n/an/a 6.40n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D)


(Homo sapiens (Human))
BDBM238348
PNG
(US9388165, 4)
Show SMILES Cc1ccc(cc1NC(=O)c1cccc2c(N)nccc12)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H18ClF3N4O2/c1-13-5-6-14(23(34)32-15-7-8-20(26)19(12-15)25(27,28)29)11-21(13)33-24(35)18-4-2-3-17-16(18)9-10-31-22(17)30/h2-12H,1H3,(H2,30,31)(H,32,34)(H,33,35)
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n/an/a 10.7n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D)


(Homo sapiens (Human))
BDBM238346
PNG
(US9388165, 2)
Show SMILES Cc1ccc(cc1NC(=O)c1cccc2c(NC(C)(C)C)nccc12)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C29H27F3N4O2/c1-17-11-12-18(26(37)34-20-8-5-7-19(16-20)29(30,31)32)15-24(17)35-27(38)23-10-6-9-22-21(23)13-14-33-25(22)36-28(2,3)4/h5-16H,1-4H3,(H,33,36)(H,34,37)(H,35,38)
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n/an/a 11n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D)


(Homo sapiens (Human))
BDBM238350
PNG
(US9388165, 8)
Show SMILES Cc1ccc(cc1NC(=O)c1cccc2c(NC(C)(C)C)nccc12)C(=O)Nc1ccccc1
Show InChI InChI=1S/C28H28N4O2/c1-18-13-14-19(26(33)30-20-9-6-5-7-10-20)17-24(18)31-27(34)23-12-8-11-22-21(23)15-16-29-25(22)32-28(2,3)4/h5-17H,1-4H3,(H,29,32)(H,30,33)(H,31,34)
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HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM238345
PNG
(US9388165, 1)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
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HANMI PHARM. CO., LTD.

US Patent


Assay Description
In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM238345
PNG
(US9388165, 1)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
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HANMI PHARM. CO., LTD.

US Patent


Assay Description
In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...


Citation and Details
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM238345
PNG
(US9388165, 1)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
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HANMI PHARM. CO., LTD.

US Patent


Assay Description
In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...


Citation and Details
More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D)


(Homo sapiens (Human))
BDBM238351
PNG
(US9388165, 11)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(NC(=O)c3cccc4c(N)nccc34)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H23F3N6O2/c1-16-6-7-18(10-25(16)37-28(40)24-5-3-4-23-22(24)8-9-34-26(23)33)27(39)36-20-11-19(29(30,31)32)12-21(13-20)38-14-17(2)35-15-38/h3-15H,1-2H3,(H2,33,34)(H,36,39)(H,37,40)
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n/an/a 94.8n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D)


(Homo sapiens (Human))
BDBM238352
PNG
(US9388165, 14)
Show SMILES Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H20F3N5O2/c1-14-8-9-17(32-24(35)31-16-5-2-4-15(12-16)25(26,27)28)13-21(14)33-23(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,33,34)(H2,31,32,35)
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n/an/a 108n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D)


(Homo sapiens (Human))
BDBM50396483
PNG
(PLX-4032 | RG 7204 | Ro 5185426 | US9388165, Refer...)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
Show InChI InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
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n/an/a 128n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM238345
PNG
(US9388165, 1)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
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HANMI PHARM. CO., LTD.

US Patent


Assay Description
In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM238345
PNG
(US9388165, 1)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
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HANMI PHARM. CO., LTD.

US Patent


Assay Description
In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM238345
PNG
(US9388165, 1)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
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n/an/a>2.50E+3n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM238345
PNG
(US9388165, 1)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
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n/an/a>2.50E+3n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM238345
PNG
(US9388165, 1)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
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HANMI PHARM. CO., LTD.

US Patent


Assay Description
In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM238345
PNG
(US9388165, 1)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
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HANMI PHARM. CO., LTD.

US Patent


Assay Description
In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...


Citation and Details
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM238345
PNG
(US9388165, 1)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
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HANMI PHARM. CO., LTD.

US Patent


Assay Description
In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...


Citation and Details
More data for this
Ligand-Target Pair
Epidermal growth factor receptor and ErbB2 (HER1 and HER2)


(Homo sapiens (human))
BDBM238345
PNG
(US9388165, 1)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
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HANMI PHARM. CO., LTD.

US Patent


Assay Description
In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...


Citation and Details
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM238345
PNG
(US9388165, 1)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
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UniChem
US Patent
n/an/a>2.50E+3n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM238345
PNG
(US9388165, 1)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>2.50E+3n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%