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Patent code US9388176

Compile Data Set for Download or QSAR
Found 119 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139623
PNG
(US8889870, 171 | US9388176, 171)
Show SMILES COC(=O)c1cncc2CN(CCc12)c1cccc(c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H20F3N3O3/c1-33-23(32)21-13-28-12-16-14-30(9-8-20(16)21)19-7-2-4-15(10-19)22(31)29-18-6-3-5-17(11-18)24(25,26)27/h2-7,10-13H,8-9,14H2,1H3,(H,29,31)
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n/an/a 8n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236904
PNG
(US9388176, 139 | US9388176, 147)
Show SMILES CSc1ncc2CN(CCc2n1)c1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H21F3N4OS/c1-14-6-7-15(21(31)28-18-5-3-4-17(11-18)23(24,25)26)10-20(14)30-9-8-19-16(13-30)12-27-22(29-19)32-2/h3-7,10-12H,8-9,13H2,1-2H3,(H,28,31)
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n/an/a 8n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139608
PNG
(US8889870, 154 | US9388176, 154)
Show SMILES CC(C)c1cccc(NC(=O)c2ccc(C)c(c2)N2CCc3ncncc3C2)c1
Show InChI InChI=1S/C24H26N4O/c1-16(2)18-5-4-6-21(11-18)27-24(29)19-8-7-17(3)23(12-19)28-10-9-22-20(14-28)13-25-15-26-22/h4-8,11-13,15-16H,9-10,14H2,1-3H3,(H,27,29)
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n/an/a 11n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139542
PNG
(US8889870, 2 | US9388176, 2)
Show SMILES CC(C)c1cccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C23H25N5O/c1-15(2)16-5-3-7-19(11-16)26-22(29)17-6-4-8-20(12-17)28-10-9-21-18(14-28)13-25-23(24)27-21/h3-8,11-13,15H,9-10,14H2,1-2H3,(H,26,29)(H2,24,25,27)
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n/an/a 12n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139621
PNG
(US8889870, 169 | US9388176, 169)
Show SMILES COC(=O)c1cncc2CN(CCc12)c1cccc(c1)C(=O)Nc1cccc(c1)C(C)C
Show InChI InChI=1S/C26H27N3O3/c1-17(2)18-6-4-8-21(12-18)28-25(30)19-7-5-9-22(13-19)29-11-10-23-20(16-29)14-27-15-24(23)26(31)32-3/h4-9,12-15,17H,10-11,16H2,1-3H3,(H,28,30)
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n/an/a 12n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139545
PNG
(US8889870, 5 | US9388176, 5)
Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)15-4-2-5-16(10-15)27-19(30)13-3-1-6-17(9-13)29-8-7-18-14(12-29)11-26-20(25)28-18/h1-6,9-11H,7-8,12H2,(H,27,30)(H2,25,26,28)
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n/an/a 12n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139603
PNG
(US8889870, 149 | US9388176, 149)
Show SMILES CC(C)c1cccc(NC(=O)c2ccc(C)c(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C24H27N5O/c1-15(2)17-5-4-6-20(11-17)27-23(30)18-8-7-16(3)22(12-18)29-10-9-21-19(14-29)13-26-24(25)28-21/h4-8,11-13,15H,9-10,14H2,1-3H3,(H,27,30)(H2,25,26,28)
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n/an/a 14n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139621
PNG
(US8889870, 169 | US9388176, 169)
Show SMILES COC(=O)c1cncc2CN(CCc12)c1cccc(c1)C(=O)Nc1cccc(c1)C(C)C
Show InChI InChI=1S/C26H27N3O3/c1-17(2)18-6-4-8-21(12-18)28-25(30)19-7-5-9-22(13-19)29-11-10-23-20(16-29)14-27-15-24(23)26(31)32-3/h4-9,12-15,17H,10-11,16H2,1-3H3,(H,28,30)
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n/an/a 15n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139604
PNG
(US8889870, 150 | US9388176, 150)
Show SMILES CC(C)c1cccc(NC(=O)c2cc(C)cc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C24H27N5O/c1-15(2)17-5-4-6-20(11-17)27-23(30)18-9-16(3)10-21(12-18)29-8-7-22-19(14-29)13-26-24(25)28-22/h4-6,9-13,15H,7-8,14H2,1-3H3,(H,27,30)(H2,25,26,28)
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n/an/a 17n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139605
PNG
(US8889870, 151 | US9388176, 151)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2cccc(c2)N2CCc3ncncc3C2)c1
Show InChI InChI=1S/C21H17F3N4O/c22-21(23,24)16-4-2-5-17(10-16)27-20(29)14-3-1-6-18(9-14)28-8-7-19-15(12-28)11-25-13-26-19/h1-6,9-11,13H,7-8,12H2,(H,27,29)
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n/an/a 19n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM236904
PNG
(US9388176, 139 | US9388176, 147)
Show SMILES CSc1ncc2CN(CCc2n1)c1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H21F3N4OS/c1-14-6-7-15(21(31)28-18-5-3-4-17(11-18)23(24,25)26)10-20(14)30-9-8-19-16(13-30)12-27-22(29-19)32-2/h3-7,10-12H,8-9,13H2,1-2H3,(H,28,31)
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n/an/a 20n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139542
PNG
(US8889870, 2 | US9388176, 2)
Show SMILES CC(C)c1cccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C23H25N5O/c1-15(2)16-5-3-7-19(11-16)26-22(29)17-6-4-8-20(12-17)28-10-9-21-18(14-28)13-25-23(24)27-21/h3-8,11-13,15H,9-10,14H2,1-2H3,(H,26,29)(H2,24,25,27)
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n/an/a 21n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139549
PNG
(US8889870, 9 | US9388176, 9)
Show SMILES CCc1cccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C22H23N5O/c1-2-15-5-3-7-18(11-15)25-21(28)16-6-4-8-19(12-16)27-10-9-20-17(14-27)13-24-22(23)26-20/h3-8,11-13H,2,9-10,14H2,1H3,(H,25,28)(H2,23,24,26)
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n/an/a 22n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139552
PNG
(US8889870, 12 | US9388176, 12)
Show SMILES CC(C)c1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C23H25N5O/c1-15(2)16-6-8-19(9-7-16)26-22(29)17-4-3-5-20(12-17)28-11-10-21-18(14-28)13-25-23(24)27-21/h3-9,12-13,15H,10-11,14H2,1-2H3,(H,26,29)(H2,24,25,27)
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n/an/a 24n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139545
PNG
(US8889870, 5 | US9388176, 5)
Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)15-4-2-5-16(10-15)27-19(30)13-3-1-6-17(9-13)29-8-7-18-14(12-29)11-26-20(25)28-18/h1-6,9-11H,7-8,12H2,(H,27,30)(H2,25,26,28)
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n/an/a 26n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139602
PNG
(US8889870, 148 | US9388176, 148)
Show SMILES Cc1cc(cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C22H20F3N5O/c1-13-7-14(20(31)28-17-4-2-3-16(10-17)22(23,24)25)9-18(8-13)30-6-5-19-15(12-30)11-27-21(26)29-19/h2-4,7-11H,5-6,12H2,1H3,(H,28,31)(H2,26,27,29)
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n/an/a 27n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139552
PNG
(US8889870, 12 | US9388176, 12)
Show SMILES CC(C)c1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C23H25N5O/c1-15(2)16-6-8-19(9-7-16)26-22(29)17-4-3-5-20(12-17)28-11-10-21-18(14-28)13-25-23(24)27-21/h3-9,12-13,15H,10-11,14H2,1-2H3,(H,26,29)(H2,24,25,27)
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n/an/a 27n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139628
PNG
(US8889870, 176 | US9388176, 176)
Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)Nc1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C21H17F4N5O/c22-17-5-4-14(9-16(17)21(23,24)25)28-19(31)12-2-1-3-15(8-12)30-7-6-18-13(11-30)10-27-20(26)29-18/h1-5,8-10H,6-7,11H2,(H,28,31)(H2,26,27,29)
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n/an/a 27n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139603
PNG
(US8889870, 149 | US9388176, 149)
Show SMILES CC(C)c1cccc(NC(=O)c2ccc(C)c(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C24H27N5O/c1-15(2)17-5-4-6-20(11-17)27-23(30)18-8-7-16(3)22(12-18)29-10-9-21-19(14-29)13-26-24(25)28-21/h4-8,11-13,15H,9-10,14H2,1-3H3,(H,27,30)(H2,25,26,28)
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n/an/a 30n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236906
PNG
(US9388176, 141)
Show SMILES CSc1ncc2CN(CCc2n1)c1cc(ccc1C)C(=O)Nc1cccc(c1)C(C)C
Show InChI InChI=1S/C25H28N4OS/c1-16(2)18-6-5-7-21(12-18)27-24(30)19-9-8-17(3)23(13-19)29-11-10-22-20(15-29)14-26-25(28-22)31-4/h5-9,12-14,16H,10-11,15H2,1-4H3,(H,27,30)
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n/an/a 31n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139550
PNG
(US8889870, 10 | US9388176, 10)
Show SMILES CCCc1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C23H25N5O/c1-2-4-16-7-9-19(10-8-16)26-22(29)17-5-3-6-20(13-17)28-12-11-21-18(15-28)14-25-23(24)27-21/h3,5-10,13-14H,2,4,11-12,15H2,1H3,(H,26,29)(H2,24,25,27)
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n/an/a 32n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139618
PNG
(US8889870, 166 | US9388176, 166)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(N3CCc4ccncc4C3)c(C)c2)c1
Show InChI InChI=1S/C23H24N4O/c1-16-4-3-5-20(12-16)25-23(28)26-21-6-7-22(17(2)13-21)27-11-9-18-8-10-24-14-19(18)15-27/h3-8,10,12-14H,9,11,15H2,1-2H3,(H2,25,26,28)
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n/an/a 36n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139620
PNG
(US8889870, 168 | US9388176, 168)
Show SMILES CC(C)c1cccc(NC(=O)c2cccc(c2)N2CCc3ccncc3C2)c1
Show InChI InChI=1S/C24H25N3O/c1-17(2)19-5-3-7-22(13-19)26-24(28)20-6-4-8-23(14-20)27-12-10-18-9-11-25-15-21(18)16-27/h3-9,11,13-15,17H,10,12,16H2,1-2H3,(H,26,28)
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n/an/a 39n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139620
PNG
(US8889870, 168 | US9388176, 168)
Show SMILES CC(C)c1cccc(NC(=O)c2cccc(c2)N2CCc3ccncc3C2)c1
Show InChI InChI=1S/C24H25N3O/c1-17(2)19-5-3-7-22(13-19)26-24(28)20-6-4-8-23(14-20)27-12-10-18-9-11-25-15-21(18)16-27/h3-9,11,13-15,17H,10,12,16H2,1-2H3,(H,26,28)
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n/an/a 40n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139544
PNG
(US8889870, 4 | US9388176, 4)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C24H27N5O/c1-24(2,3)18-7-9-19(10-8-18)27-22(30)16-5-4-6-20(13-16)29-12-11-21-17(15-29)14-26-23(25)28-21/h4-10,13-14H,11-12,15H2,1-3H3,(H,27,30)(H2,25,26,28)
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n/an/a 41n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139626
PNG
(US8889870, 174 | US9388176, 174)
Show SMILES COC(=O)CNC(=O)c1cncc2CN(CCc12)c1cccc(c1)C(=O)Nc1cccc(c1)C(C)C
Show InChI InChI=1S/C28H30N4O4/c1-18(2)19-6-4-8-22(12-19)31-27(34)20-7-5-9-23(13-20)32-11-10-24-21(17-32)14-29-15-25(24)28(35)30-16-26(33)36-3/h4-9,12-15,18H,10-11,16-17H2,1-3H3,(H,30,35)(H,31,34)
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n/an/a 49n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139549
PNG
(US8889870, 9 | US9388176, 9)
Show SMILES CCc1cccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C22H23N5O/c1-2-15-5-3-7-18(11-15)25-21(28)16-6-4-8-19(12-16)27-10-9-20-17(14-27)13-24-22(23)26-20/h3-8,11-13H,2,9-10,14H2,1H3,(H,25,28)(H2,23,24,26)
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n/an/a 52n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139622
PNG
(US8889870, 170 | US9388176, 170)
Show SMILES CC(C)c1cccc(NC(=O)c2cccc(c2)N2CCc3c(C2)cncc3C(O)=O)c1
Show InChI InChI=1S/C25H25N3O3/c1-16(2)17-5-3-7-20(11-17)27-24(29)18-6-4-8-21(12-18)28-10-9-22-19(15-28)13-26-14-23(22)25(30)31/h3-8,11-14,16H,9-10,15H2,1-2H3,(H,27,29)(H,30,31)
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n/an/a 54n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139604
PNG
(US8889870, 150 | US9388176, 150)
Show SMILES CC(C)c1cccc(NC(=O)c2cc(C)cc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C24H27N5O/c1-15(2)17-5-4-6-20(11-17)27-23(30)18-9-16(3)10-21(12-18)29-8-7-22-19(14-29)13-26-24(25)28-22/h4-6,9-13,15H,7-8,14H2,1-3H3,(H,27,30)(H2,25,26,28)
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n/an/a 59n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139628
PNG
(US8889870, 176 | US9388176, 176)
Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)Nc1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C21H17F4N5O/c22-17-5-4-14(9-16(17)21(23,24)25)28-19(31)12-2-1-3-15(8-12)30-7-6-18-13(11-30)10-27-20(26)29-18/h1-5,8-10H,6-7,11H2,(H,28,31)(H2,26,27,29)
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n/an/a 61n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139550
PNG
(US8889870, 10 | US9388176, 10)
Show SMILES CCCc1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C23H25N5O/c1-2-4-16-7-9-19(10-8-16)26-22(29)17-5-3-6-20(13-17)28-12-11-21-18(15-28)14-25-23(24)27-21/h3,5-10,13-14H,2,4,11-12,15H2,1H3,(H,26,29)(H2,24,25,27)
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n/an/a 67n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236904
PNG
(US9388176, 139 | US9388176, 147)
Show SMILES CSc1ncc2CN(CCc2n1)c1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H21F3N4OS/c1-14-6-7-15(21(31)28-18-5-3-4-17(11-18)23(24,25)26)10-20(14)30-9-8-19-16(13-30)12-27-22(29-19)32-2/h3-7,10-12H,8-9,13H2,1-2H3,(H,28,31)
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n/an/a 71n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139546
PNG
(US8889870, 6 | US9388176, 6)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C21H21N5O/c1-14-5-7-17(8-6-14)24-20(27)15-3-2-4-18(11-15)26-10-9-19-16(13-26)12-23-21(22)25-19/h2-8,11-12H,9-10,13H2,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 90n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139547
PNG
(US8889870, 7 | US9388176, 7)
Show SMILES COc1cccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C21H21N5O2/c1-28-18-7-3-5-16(11-18)24-20(27)14-4-2-6-17(10-14)26-9-8-19-15(13-26)12-23-21(22)25-19/h2-7,10-12H,8-9,13H2,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 102n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139606
PNG
(US8889870, 152 | US9388176, 152)
Show SMILES Cc1ccc(cc1N1CCc2ncncc2C1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H19F3N4O/c1-14-5-6-15(21(30)28-18-4-2-3-17(10-18)22(23,24)25)9-20(14)29-8-7-19-16(12-29)11-26-13-27-19/h2-6,9-11,13H,7-8,12H2,1H3,(H,28,30)
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n/an/a 104n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139544
PNG
(US8889870, 4 | US9388176, 4)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C24H27N5O/c1-24(2,3)18-7-9-19(10-8-18)27-22(30)16-5-4-6-20(13-16)29-12-11-21-17(15-29)14-26-23(25)28-21/h4-10,13-14H,11-12,15H2,1-3H3,(H,27,30)(H2,25,26,28)
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n/an/a 109n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139543
PNG
(US8889870, 3 | US9388176, 3)
Show SMILES Cc1cccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C21H21N5O/c1-14-4-2-6-17(10-14)24-20(27)15-5-3-7-18(11-15)26-9-8-19-16(13-26)12-23-21(22)25-19/h2-7,10-12H,8-9,13H2,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 114n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139543
PNG
(US8889870, 3 | US9388176, 3)
Show SMILES Cc1cccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C21H21N5O/c1-14-4-2-6-17(10-14)24-20(27)15-5-3-7-18(11-15)26-9-8-19-16(13-26)12-23-21(22)25-19/h2-7,10-12H,8-9,13H2,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 116n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139548
PNG
(US8889870, 8 | US9388176, 8)
Show SMILES CCc1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C22H23N5O/c1-2-15-6-8-18(9-7-15)25-21(28)16-4-3-5-19(12-16)27-11-10-20-17(14-27)13-24-22(23)26-20/h3-9,12-13H,2,10-11,14H2,1H3,(H,25,28)(H2,23,24,26)
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n/an/a 134n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139548
PNG
(US8889870, 8 | US9388176, 8)
Show SMILES CCc1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C22H23N5O/c1-2-15-6-8-18(9-7-15)25-21(28)16-4-3-5-19(12-16)27-11-10-20-17(14-27)13-24-22(23)26-20/h3-9,12-13H,2,10-11,14H2,1H3,(H,25,28)(H2,23,24,26)
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n/an/a 145n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139613
PNG
(US8889870, 161 | US9388176, 161)
Show SMILES CC(C)c1cccc(NC(=O)c2cncc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C22H24N6O/c1-14(2)15-4-3-5-18(8-15)26-21(29)16-9-19(12-24-10-16)28-7-6-20-17(13-28)11-25-22(23)27-20/h3-5,8-12,14H,6-7,13H2,1-2H3,(H,26,29)(H2,23,25,27)
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n/an/a 149n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139609
PNG
(US8889870, 155 | US9388176, 155)
Show SMILES CC(C)c1cccc(NC(=O)c2cc(C)cc(c2)N2CCc3ncncc3C2)c1
Show InChI InChI=1S/C24H26N4O/c1-16(2)18-5-4-6-21(11-18)27-24(29)19-9-17(3)10-22(12-19)28-8-7-23-20(14-28)13-25-15-26-23/h4-6,9-13,15-16H,7-8,14H2,1-3H3,(H,27,29)
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n/an/a 159n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139560
PNG
(US8889870, 20 | US9388176, 20)
Show SMILES CC(C)(C)CCNC(=O)c1cccc(c1)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C20H27N5O/c1-20(2,3)8-9-22-18(26)14-5-4-6-16(11-14)25-10-7-17-15(13-25)12-23-19(21)24-17/h4-6,11-12H,7-10,13H2,1-3H3,(H,22,26)(H2,21,23,24)
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n/an/a 164n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139625
PNG
(US8889870, 173 | US9388176, 173)
Show SMILES CC(C)c1cccc(NC(=O)c2cccc(c2)N2CCc3c(C2)cncc3C(=O)NCCCO)c1
Show InChI InChI=1S/C28H32N4O3/c1-19(2)20-6-3-8-23(14-20)31-27(34)21-7-4-9-24(15-21)32-12-10-25-22(18-32)16-29-17-26(25)28(35)30-11-5-13-33/h3-4,6-9,14-17,19,33H,5,10-13,18H2,1-2H3,(H,30,35)(H,31,34)
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n/an/a 220n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139627
PNG
(US8889870, 175 | US9388176, 175)
Show SMILES CC(C)c1cccc(NC(=O)c2cccc(c2)N2CCc3c(C2)cncc3C(=O)NCCCN2CCCC2)c1
Show InChI InChI=1S/C32H39N5O2/c1-23(2)24-8-5-10-27(18-24)35-31(38)25-9-6-11-28(19-25)37-17-12-29-26(22-37)20-33-21-30(29)32(39)34-13-7-16-36-14-3-4-15-36/h5-6,8-11,18-21,23H,3-4,7,12-17,22H2,1-2H3,(H,34,39)(H,35,38)
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n/an/a 230n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139557
PNG
(US8889870, 17 | US9388176, 17)
Show SMILES CC(C)(C)C1CCC(CC1)NC(=O)c1cccc(c1)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C24H33N5O/c1-24(2,3)18-7-9-19(10-8-18)27-22(30)16-5-4-6-20(13-16)29-12-11-21-17(15-29)14-26-23(25)28-21/h4-6,13-14,18-19H,7-12,15H2,1-3H3,(H,27,30)(H2,25,26,28)
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n/an/a 246n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139602
PNG
(US8889870, 148 | US9388176, 148)
Show SMILES Cc1cc(cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C22H20F3N5O/c1-13-7-14(20(31)28-17-4-2-3-16(10-17)22(23,24)25)9-18(8-13)30-6-5-19-15(12-30)11-27-21(26)29-19/h2-4,7-11H,5-6,12H2,1H3,(H,28,31)(H2,26,27,29)
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n/an/a 273n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139557
PNG
(US8889870, 17 | US9388176, 17)
Show SMILES CC(C)(C)C1CCC(CC1)NC(=O)c1cccc(c1)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C24H33N5O/c1-24(2,3)18-7-9-19(10-8-18)27-22(30)16-5-4-6-20(13-16)29-12-11-21-17(15-29)14-26-23(25)28-21/h4-6,13-14,18-19H,7-12,15H2,1-3H3,(H,27,30)(H2,25,26,28)
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n/an/a 307n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139618
PNG
(US8889870, 166 | US9388176, 166)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(N3CCc4ccncc4C3)c(C)c2)c1
Show InChI InChI=1S/C23H24N4O/c1-16-4-3-5-20(12-16)25-23(28)26-21-6-7-22(17(2)13-21)27-11-9-18-8-10-24-14-19(18)15-27/h3-8,10,12-14H,9,11,15H2,1-2H3,(H2,25,26,28)
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n/an/a 308n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139624
PNG
(US8889870, 172 | US9388176, 172)
Show SMILES CC(C)c1cccc(NC(=O)c2cccc(c2)N2CCc3c(C2)cncc3C(=O)NCCCN2CCOCC2)c1
Show InChI InChI=1S/C32H39N5O3/c1-23(2)24-6-3-8-27(18-24)35-31(38)25-7-4-9-28(19-25)37-13-10-29-26(22-37)20-33-21-30(29)32(39)34-11-5-12-36-14-16-40-17-15-36/h3-4,6-9,18-21,23H,5,10-17,22H2,1-2H3,(H,34,39)(H,35,38)
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n/an/a 367n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139619
PNG
(US8889870, 167 | US9388176, 167)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2C)N2CCc3ccncc3C2)c1
Show InChI InChI=1S/C23H24N4O/c1-16-4-3-5-20(12-16)25-23(28)26-22-7-6-21(13-17(22)2)27-11-9-18-8-10-24-14-19(18)15-27/h3-8,10,12-14H,9,11,15H2,1-2H3,(H2,25,26,28)
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n/an/a 454n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139560
PNG
(US8889870, 20 | US9388176, 20)
Show SMILES CC(C)(C)CCNC(=O)c1cccc(c1)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C20H27N5O/c1-20(2,3)8-9-22-18(26)14-5-4-6-16(11-14)25-10-7-17-15(13-25)12-23-19(21)24-17/h4-6,11-12H,7-10,13H2,1-3H3,(H,22,26)(H2,21,23,24)
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n/an/a 566n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139612
PNG
(US8889870, 160 | US9388176, 160)
Show SMILES Nc1ncc2CN(CCc2n1)c1cncc(c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H17F3N6O/c21-20(22,23)14-2-1-3-15(7-14)27-18(30)12-6-16(10-25-8-12)29-5-4-17-13(11-29)9-26-19(24)28-17/h1-3,6-10H,4-5,11H2,(H,27,30)(H2,24,26,28)
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n/an/a 584n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139558
PNG
(US8889870, 18 | US9388176, 18)
Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)NCC1CCCCC1
Show InChI InChI=1S/C21H27N5O/c22-21-24-13-17-14-26(10-9-19(17)25-21)18-8-4-7-16(11-18)20(27)23-12-15-5-2-1-3-6-15/h4,7-8,11,13,15H,1-3,5-6,9-10,12,14H2,(H,23,27)(H2,22,24,25)
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n/an/a 602n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139607
PNG
(US8889870, 153 | US9388176, 153)
Show SMILES Cc1cc(cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F)N1CCc2ncncc2C1
Show InChI InChI=1S/C22H19F3N4O/c1-14-7-15(21(30)28-18-4-2-3-17(10-18)22(23,24)25)9-19(8-14)29-6-5-20-16(12-29)11-26-13-27-20/h2-4,7-11,13H,5-6,12H2,1H3,(H,28,30)
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n/an/a 638n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236903
PNG
(US9388176, 138)
Show SMILES CSc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H19F3N4OS/c1-31-21-26-12-15-13-29(9-8-19(15)28-21)18-7-2-4-14(10-18)20(30)27-17-6-3-5-16(11-17)22(23,24)25/h2-7,10-12H,8-9,13H2,1H3,(H,27,30)
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n/an/a 764n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139546
PNG
(US8889870, 6 | US9388176, 6)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C21H21N5O/c1-14-5-7-17(8-6-14)24-20(27)15-3-2-4-18(11-15)26-10-9-19-16(13-26)12-23-21(22)25-19/h2-8,11-12H,9-10,13H2,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 783n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139551
PNG
(US8889870, 11 | US9388176, 11)
Show SMILES CN1CCC(CC1)Oc1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C26H30N6O2/c1-31-12-9-23(10-13-31)34-22-7-5-20(6-8-22)29-25(33)18-3-2-4-21(15-18)32-14-11-24-19(17-32)16-28-26(27)30-24/h2-8,15-16,23H,9-14,17H2,1H3,(H,29,33)(H2,27,28,30)
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n/an/a>1.00E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236907
PNG
(US9388176, 142)
Show SMILES CSc1ncc2CN(CCc2n1)c1cc(C)cc(c1)C(=O)Nc1cccc(c1)C(C)C
Show InChI InChI=1S/C25H28N4OS/c1-16(2)18-6-5-7-21(12-18)27-24(30)19-10-17(3)11-22(13-19)29-9-8-23-20(15-29)14-26-25(28-23)31-4/h5-7,10-14,16H,8-9,15H2,1-4H3,(H,27,30)
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n/an/a>1.00E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139617
PNG
(US8889870, 165 | US9388176, 165)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)N2CCc3ccncc3C2)cc1
Show InChI InChI=1S/C22H22N4O/c1-16-2-4-19(5-3-16)24-22(27)25-20-6-8-21(9-7-20)26-13-11-17-10-12-23-14-18(17)15-26/h2-10,12,14H,11,13,15H2,1H3,(H2,24,25,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139561
PNG
(US8889870, 21 | US9388176, 21)
Show SMILES CCN(CC)C(=O)c1cccc(c1)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C18H23N5O/c1-3-22(4-2)17(24)13-6-5-7-15(10-13)23-9-8-16-14(12-23)11-20-18(19)21-16/h5-7,10-11H,3-4,8-9,12H2,1-2H3,(H2,19,20,21)
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n/an/a>1.00E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236905
PNG
(US9388176, 140)
Show SMILES CSc1ncc2CN(CCc2n1)c1cc(C)cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H21F3N4OS/c1-14-8-15(21(31)28-18-5-3-4-17(11-18)23(24,25)26)10-19(9-14)30-7-6-20-16(13-30)12-27-22(29-20)32-2/h3-5,8-12H,6-7,13H2,1-2H3,(H,28,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139617
PNG
(US8889870, 165 | US9388176, 165)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)N2CCc3ccncc3C2)cc1
Show InChI InChI=1S/C22H22N4O/c1-16-2-4-19(5-3-16)24-22(27)25-20-6-8-21(9-7-20)26-13-11-17-10-12-23-14-18(17)15-26/h2-10,12,14H,11,13,15H2,1H3,(H2,24,25,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139556
PNG
(US8889870, 16 | US9388176, 16)
Show SMILES CCCCNC(=O)c1cccc(c1)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C18H23N5O/c1-2-3-8-20-17(24)13-5-4-6-15(10-13)23-9-7-16-14(12-23)11-21-18(19)22-16/h4-6,10-11H,2-3,7-9,12H2,1H3,(H,20,24)(H2,19,21,22)
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n/an/a>1.00E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139619
PNG
(US8889870, 167 | US9388176, 167)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2C)N2CCc3ccncc3C2)c1
Show InChI InChI=1S/C23H24N4O/c1-16-4-3-5-20(12-16)25-23(28)26-22-7-6-21(13-17(22)2)27-11-9-18-8-10-24-14-19(18)15-27/h3-8,10,12-14H,9,11,15H2,1-2H3,(H2,25,26,28)
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n/an/a 1.05E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139551
PNG
(US8889870, 11 | US9388176, 11)
Show SMILES CN1CCC(CC1)Oc1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C26H30N6O2/c1-31-12-9-23(10-13-31)34-22-7-5-20(6-8-22)29-25(33)18-3-2-4-21(15-18)32-14-11-24-19(17-32)16-28-26(27)30-24/h2-8,15-16,23H,9-14,17H2,1H3,(H,29,33)(H2,27,28,30)
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n/an/a 1.18E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139547
PNG
(US8889870, 7 | US9388176, 7)
Show SMILES COc1cccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C21H21N5O2/c1-28-18-7-3-5-16(11-18)24-20(27)14-4-2-6-17(10-14)26-9-8-19-15(13-26)12-23-21(22)25-19/h2-7,10-12H,8-9,13H2,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 1.24E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139561
PNG
(US8889870, 21 | US9388176, 21)
Show SMILES CCN(CC)C(=O)c1cccc(c1)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C18H23N5O/c1-3-22(4-2)17(24)13-6-5-7-15(10-13)23-9-8-16-14(12-23)11-20-18(19)21-16/h5-7,10-11H,3-4,8-9,12H2,1-2H3,(H2,19,20,21)
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n/an/a 1.25E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139615
PNG
(US8889870, 163 | US9388176, 163)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)N2CCc3ccncc3C2)c1
Show InChI InChI=1S/C22H22N4O/c1-16-3-2-4-20(13-16)25-22(27)24-19-5-7-21(8-6-19)26-12-10-17-9-11-23-14-18(17)15-26/h2-9,11,13-14H,10,12,15H2,1H3,(H2,24,25,27)
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n/an/a 1.56E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139583
PNG
(US8889870, 107 | US9388176, 107)
Show SMILES Nc1ncc2CN(Cc2n1)c1cccc(c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H16F3N5O/c21-20(22,23)14-4-2-5-15(8-14)26-18(29)12-3-1-6-16(7-12)28-10-13-9-25-19(24)27-17(13)11-28/h1-9H,10-11H2,(H,26,29)(H2,24,25,27)
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n/an/a 2.13E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139558
PNG
(US8889870, 18 | US9388176, 18)
Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)NCC1CCCCC1
Show InChI InChI=1S/C21H27N5O/c22-21-24-13-17-14-26(10-9-19(17)25-21)18-8-4-7-16(11-18)20(27)23-12-15-5-2-1-3-6-15/h4,7-8,11,13,15H,1-3,5-6,9-10,12,14H2,(H,23,27)(H2,22,24,25)
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n/an/a 2.13E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139615
PNG
(US8889870, 163 | US9388176, 163)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)N2CCc3ccncc3C2)c1
Show InChI InChI=1S/C22H22N4O/c1-16-3-2-4-20(13-16)25-22(27)24-19-5-7-21(8-6-19)26-12-10-17-9-11-23-14-18(17)15-26/h2-9,11,13-14H,10,12,15H2,1H3,(H2,24,25,27)
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n/an/a 2.20E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139541
PNG
(US8889870, 1 | US9388176, 1)
Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C20H19N5O/c21-20-22-12-15-13-25(10-9-18(15)24-20)17-8-4-5-14(11-17)19(26)23-16-6-2-1-3-7-16/h1-8,11-12H,9-10,13H2,(H,23,26)(H2,21,22,24)
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n/an/a 2.98E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139582
PNG
(US8889870, 106 | US9388176, 106)
Show SMILES CC(C)c1cccc(NC(=O)c2cccc(c2)N2Cc3cnc(N)nc3C2)c1
Show InChI InChI=1S/C22H23N5O/c1-14(2)15-5-3-7-18(9-15)25-21(28)16-6-4-8-19(10-16)27-12-17-11-24-22(23)26-20(17)13-27/h3-11,14H,12-13H2,1-2H3,(H,25,28)(H2,23,24,26)
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n/an/a 6.36E+3n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139572
PNG
(US8889870, 51 | US9388176, 51)
Show SMILES Nc1ncc2CN(CCc2n1)c1cc(ccn1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C19H18N6O/c20-19-22-11-14-12-25(9-7-16(14)24-19)17-10-13(6-8-21-17)18(26)23-15-4-2-1-3-5-15/h1-6,8,10-11H,7,9,12H2,(H,23,26)(H2,20,22,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139580
PNG
(US8889870, 83 | US9388176, 83)
Show SMILES CC(C)c1ccc(NC(=O)c2cc(ccn2)N2Cc3cnc(N)nc3C2)cc1
Show InChI InChI=1S/C21H22N6O/c1-13(2)14-3-5-16(6-4-14)25-20(28)18-9-17(7-8-23-18)27-11-15-10-24-21(22)26-19(15)12-27/h3-10,13H,11-12H2,1-2H3,(H,25,28)(H2,22,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236900
PNG
(US9388176, 126)
Show SMILES CSc1ncc2CN(Cc2n1)c1ccnc(c1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H16F3N5OS/c1-30-19-25-9-12-10-28(11-17(12)27-19)15-6-7-24-16(8-15)18(29)26-14-4-2-13(3-5-14)20(21,22)23/h2-9H,10-11H2,1H3,(H,26,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236901
PNG
(US9388176, 128)
Show SMILES CSc1ncc2CN(Cc2n1)c1ccnc(c1)C(=O)Nc1cccc(c1)C(C)C
Show InChI InChI=1S/C22H23N5OS/c1-14(2)15-5-4-6-17(9-15)25-21(28)19-10-18(7-8-23-19)27-12-16-11-24-22(29-3)26-20(16)13-27/h4-11,14H,12-13H2,1-3H3,(H,25,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236902
PNG
(US9388176, 129)
Show SMILES CSc1ncc2CN(Cc2n1)c1ccnc(c1)C(=O)Nc1ccc(cc1)C(C)C
Show InChI InChI=1S/C22H23N5OS/c1-14(2)15-4-6-17(7-5-15)25-21(28)19-10-18(8-9-23-19)27-12-16-11-24-22(29-3)26-20(16)13-27/h4-11,14H,12-13H2,1-3H3,(H,25,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139556
PNG
(US8889870, 16 | US9388176, 16)
Show SMILES CCCCNC(=O)c1cccc(c1)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C18H23N5O/c1-2-3-8-20-17(24)13-5-4-6-15(10-13)23-9-7-16-14(12-23)11-21-18(19)22-16/h4-6,10-11H,2-3,7-9,12H2,1H3,(H,20,24)(H2,19,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139563
PNG
(US8889870, 23 | US9388176, 23)
Show SMILES Cc1cccc(NC(=O)c2cc(ccn2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C20H20N6O/c1-13-3-2-4-15(9-13)24-19(27)18-10-16(5-7-22-18)26-8-6-17-14(12-26)11-23-20(21)25-17/h2-5,7,9-11H,6,8,12H2,1H3,(H,24,27)(H2,21,23,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236894
PNG
(US9388176, 114)
Show SMILES CSc1ncc2CN(CCc2n1)c1cccc(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C20H19N5OS/c1-27-20-21-12-14-13-25(11-10-16(14)24-20)18-9-5-8-17(23-18)19(26)22-15-6-3-2-4-7-15/h2-9,12H,10-11,13H2,1H3,(H,22,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139614
PNG
(US8889870, 162 | US9388176, 162)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1ccc(cc1)N1CCc2ccncc2C1
Show InChI InChI=1S/C22H18F3N3O/c23-22(24,25)18-3-1-2-16(12-18)21(29)27-19-4-6-20(7-5-19)28-11-9-15-8-10-26-13-17(15)14-28/h1-8,10,12-13H,9,11,14H2,(H,27,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139562
PNG
(US8889870, 22 | US9388176, 22)
Show SMILES Nc1ncc2CN(CCc2n1)c1ccnc(c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C19H18N6O/c20-19-22-11-13-12-25(9-7-16(13)24-19)15-6-8-21-17(10-15)18(26)23-14-4-2-1-3-5-14/h1-6,8,10-11H,7,9,12H2,(H,23,26)(H2,20,22,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139571
PNG
(US8889870, 40 | US9388176, 40)
Show SMILES CC(C)c1ccc(NC(=O)c2cccc(n2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C22H24N6O/c1-14(2)15-6-8-17(9-7-15)25-21(29)19-4-3-5-20(26-19)28-11-10-18-16(13-28)12-24-22(23)27-18/h3-9,12,14H,10-11,13H2,1-2H3,(H,25,29)(H2,23,24,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236895
PNG
(US9388176, 115)
Show SMILES CSc1ncc2CN(CCc2n1)c1cccc(n1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C21H21N5OS/c1-14-5-3-6-16(11-14)23-20(27)18-7-4-8-19(24-18)26-10-9-17-15(13-26)12-22-21(25-17)28-2/h3-8,11-12H,9-10,13H2,1-2H3,(H,23,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139570
PNG
(US8889870, 39 | US9388176, 39)
Show SMILES CC(C)c1cccc(NC(=O)c2cccc(n2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C22H24N6O/c1-14(2)15-5-3-6-17(11-15)25-21(29)19-7-4-8-20(26-19)28-10-9-18-16(13-28)12-24-22(23)27-18/h3-8,11-12,14H,9-10,13H2,1-2H3,(H,25,29)(H2,23,24,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236893
PNG
(US9388176, 112)
Show SMILES CSc1ncc2CN(CCc2n1)c1cccc(n1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H18F3N5OS/c1-31-20-25-11-13-12-29(9-8-16(13)28-20)18-7-3-6-17(27-18)19(30)26-15-5-2-4-14(10-15)21(22,23)24/h2-7,10-11H,8-9,12H2,1H3,(H,26,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139614
PNG
(US8889870, 162 | US9388176, 162)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1ccc(cc1)N1CCc2ccncc2C1
Show InChI InChI=1S/C22H18F3N3O/c23-22(24,25)18-3-1-2-16(12-18)21(29)27-19-4-6-20(7-5-19)28-11-9-15-8-10-26-13-17(15)14-28/h1-8,10,12-13H,9,11,14H2,(H,27,29)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139559
PNG
(US8889870, 19 | US9388176, 19)
Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C19H23N5O/c20-19-21-11-14-12-24(9-8-17(14)23-19)16-7-3-4-13(10-16)18(25)22-15-5-1-2-6-15/h3-4,7,10-11,15H,1-2,5-6,8-9,12H2,(H,22,25)(H2,20,21,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139553
PNG
(US8889870, 13 | US9388176, 13)
Show SMILES Nc1ncc2CN(CCc2n1)c1ccc(cc1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C20H19N5O/c21-20-22-12-15-13-25(11-10-18(15)24-20)17-8-6-14(7-9-17)19(26)23-16-4-2-1-3-5-16/h1-9,12H,10-11,13H2,(H,23,26)(H2,21,22,24)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139559
PNG
(US8889870, 19 | US9388176, 19)
Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C19H23N5O/c20-19-21-11-14-12-24(9-8-17(14)23-19)16-7-3-4-13(10-16)18(25)22-15-5-1-2-6-15/h3-4,7,10-11,15H,1-2,5-6,8-9,12H2,(H,22,25)(H2,20,21,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139565
PNG
(US8889870, 25 | US9388176, 25)
Show SMILES CC(C)c1cccc(NC(=O)c2cc(ccn2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C22H24N6O/c1-14(2)15-4-3-5-17(10-15)26-21(29)20-11-18(6-8-24-20)28-9-7-19-16(13-28)12-25-22(23)27-19/h3-6,8,10-12,14H,7,9,13H2,1-2H3,(H,26,29)(H2,23,25,27)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139577
PNG
(US8889870, 80 | US9388176, 80)
Show SMILES Nc1ncc2CN(Cc2n1)c1ccnc(c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H16N6O/c19-18-21-9-12-10-24(11-16(12)23-18)14-6-7-20-15(8-14)17(25)22-13-4-2-1-3-5-13/h1-9H,10-11H2,(H,22,25)(H2,19,21,23)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139578
PNG
(US8889870, 81 | US9388176, 81)
Show SMILES CC(C)c1cccc(NC(=O)c2cc(ccn2)N2Cc3cnc(N)nc3C2)c1
Show InChI InChI=1S/C21H22N6O/c1-13(2)14-4-3-5-16(8-14)25-20(28)18-9-17(6-7-23-18)27-11-15-10-24-21(22)26-19(15)12-27/h3-10,13H,11-12H2,1-2H3,(H,25,28)(H2,22,24,26)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236896
PNG
(US9388176, 116)
Show SMILES CSc1ncc2CN(CCc2n1)c1cc(ccn1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C20H19N5OS/c1-27-20-22-12-15-13-25(10-8-17(15)24-20)18-11-14(7-9-21-18)19(26)23-16-5-3-2-4-6-16/h2-7,9,11-12H,8,10,13H2,1H3,(H,23,26)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139616
PNG
(US8889870, 164 | US9388176, 164)
Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)N1CCc2ccncc2C1
Show InChI InChI=1S/C21H20N4O/c26-21(23-18-4-2-1-3-5-18)24-19-6-8-20(9-7-19)25-13-11-16-10-12-22-14-17(16)15-25/h1-10,12,14H,11,13,15H2,(H2,23,24,26)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139568
PNG
(US8889870, 37 | US9388176, 37)
Show SMILES Cc1cccc(NC(=O)c2cccc(n2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C20H20N6O/c1-13-4-2-5-15(10-13)23-19(27)17-6-3-7-18(24-17)26-9-8-16-14(12-26)11-22-20(21)25-16/h2-7,10-11H,8-9,12H2,1H3,(H,23,27)(H2,21,22,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM139616
PNG
(US8889870, 164 | US9388176, 164)
Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)N1CCc2ccncc2C1
Show InChI InChI=1S/C21H20N4O/c26-21(23-18-4-2-1-3-5-18)24-19-6-8-20(9-7-19)25-13-11-16-10-12-22-14-17(16)15-25/h1-10,12,14H,11,13,15H2,(H2,23,24,26)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139555
PNG
(US8889870, 15 | US9388176, 15)
Show SMILES Nc1ncc2CN(CCc2n1)c1ccc(cc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)15-2-1-3-16(10-15)27-19(30)13-4-6-17(7-5-13)29-9-8-18-14(12-29)11-26-20(25)28-18/h1-7,10-11H,8-9,12H2,(H,27,30)(H2,25,26,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139574
PNG
(US8889870, 53 | US9388176, 53)
Show SMILES CC(C)c1cccc(NC(=O)c2ccnc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C22H24N6O/c1-14(2)15-4-3-5-18(10-15)26-21(29)16-6-8-24-20(11-16)28-9-7-19-17(13-28)12-25-22(23)27-19/h3-6,8,10-12,14H,7,9,13H2,1-2H3,(H,26,29)(H2,23,25,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139579
PNG
(US8889870, 82 | US9388176, 82)
Show SMILES Nc1ncc2CN(Cc2n1)c1ccnc(c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C19H15F3N6O/c20-19(21,22)12-2-1-3-13(6-12)26-17(29)15-7-14(4-5-24-15)28-9-11-8-25-18(23)27-16(11)10-28/h1-8H,9-10H2,(H,26,29)(H2,23,25,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139581
PNG
(US8889870, 84 | US9388176, 84)
Show SMILES Nc1ncc2CN(Cc2n1)c1ccnc(c1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H15F3N6O/c20-19(21,22)12-1-3-13(4-2-12)26-17(29)15-7-14(5-6-24-15)28-9-11-8-25-18(23)27-16(11)10-28/h1-8H,9-10H2,(H,26,29)(H2,23,25,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236899
PNG
(US9388176, 120)
Show SMILES CSc1ncc2CN(CCc2n1)c1cc(ccn1)C(=O)Nc1ccc(cc1)C(C)C
Show InChI InChI=1S/C23H25N5OS/c1-15(2)16-4-6-19(7-5-16)26-22(29)17-8-10-24-21(12-17)28-11-9-20-18(14-28)13-25-23(27-20)30-3/h4-8,10,12-13,15H,9,11,14H2,1-3H3,(H,26,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139554
PNG
(US8889870, 14 | US9388176, 14)
Show SMILES Cc1cccc(NC(=O)c2ccc(cc2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C21H21N5O/c1-14-3-2-4-17(11-14)24-20(27)15-5-7-18(8-6-15)26-10-9-19-16(13-26)12-23-21(22)25-19/h2-8,11-12H,9-10,13H2,1H3,(H,24,27)(H2,22,23,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139564
PNG
(US8889870, 24 | US9388176, 24)
Show SMILES Nc1ncc2CN(CCc2n1)c1ccnc(c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H17F3N6O/c21-20(22,23)13-2-1-3-14(8-13)27-18(30)17-9-15(4-6-25-17)29-7-5-16-12(11-29)10-26-19(24)28-16/h1-4,6,8-10H,5,7,11H2,(H,27,30)(H2,24,26,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139566
PNG
(US8889870, 26 | US9388176, 26)
Show SMILES CC(C)c1ccc(NC(=O)c2cc(ccn2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C22H24N6O/c1-14(2)15-3-5-17(6-4-15)26-21(29)20-11-18(7-9-24-20)28-10-8-19-16(13-28)12-25-22(23)27-19/h3-7,9,11-12,14H,8,10,13H2,1-2H3,(H,26,29)(H2,23,25,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139575
PNG
(US8889870, 54 | US9388176, 54)
Show SMILES CC(C)c1ccc(NC(=O)c2ccnc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C22H24N6O/c1-14(2)15-3-5-18(6-4-15)26-21(29)16-7-9-24-20(11-16)28-10-8-19-17(13-28)12-25-22(23)27-19/h3-7,9,11-12,14H,8,10,13H2,1-2H3,(H,26,29)(H2,23,25,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139576
PNG
(US8889870, 55 | US9388176, 55)
Show SMILES Nc1ncc2CN(CCc2n1)c1cc(ccn1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H17F3N6O/c21-20(22,23)14-2-1-3-15(9-14)27-18(30)12-4-6-25-17(8-12)29-7-5-16-13(11-29)10-26-19(24)28-16/h1-4,6,8-10H,5,7,11H2,(H,27,30)(H2,24,26,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236891
PNG
(US9388176, 108)
Show SMILES CSc1ncc2CN(CCc2n1)c1cccc(n1)C(=O)Nc1ccc(cc1)C(C)C
Show InChI InChI=1S/C23H25N5OS/c1-15(2)16-7-9-18(10-8-16)25-22(29)20-5-4-6-21(26-20)28-12-11-19-17(14-28)13-24-23(27-19)30-3/h4-10,13,15H,11-12,14H2,1-3H3,(H,25,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236892
PNG
(US9388176, 110)
Show SMILES CSc1ncc2CN(CCc2n1)c1cccc(n1)C(=O)Nc1cccc(c1)C(C)C
Show InChI InChI=1S/C23H25N5OS/c1-15(2)16-6-4-7-18(12-16)25-22(29)20-8-5-9-21(26-20)28-11-10-19-17(14-28)13-24-23(27-19)30-3/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,25,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236897
PNG
(US9388176, 118)
Show SMILES CSc1ncc2CN(CCc2n1)c1cc(ccn1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H18F3N5OS/c1-31-20-26-11-14-12-29(8-6-17(14)28-20)18-9-13(5-7-25-18)19(30)27-16-4-2-3-15(10-16)21(22,23)24/h2-5,7,9-11H,6,8,12H2,1H3,(H,27,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236909
PNG
(US9388176, 156)
Show SMILES CSc1ncc2CN(CCc2n1)c1cncc(c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H18F3N5OS/c1-31-20-26-10-14-12-29(6-5-18(14)28-20)17-7-13(9-25-11-17)19(30)27-16-4-2-3-15(8-16)21(22,23)24/h2-4,7-11H,5-6,12H2,1H3,(H,27,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139569
PNG
(US8889870, 38 | US9388176, 38)
Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(n1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H17F3N6O/c21-20(22,23)13-3-1-4-14(9-13)26-18(30)16-5-2-6-17(27-16)29-8-7-15-12(11-29)10-25-19(24)28-15/h1-6,9-10H,7-8,11H2,(H,26,30)(H2,24,25,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139573
PNG
(US8889870, 52 | US9388176, 52)
Show SMILES Cc1cccc(NC(=O)c2ccnc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C20H20N6O/c1-13-3-2-4-16(9-13)24-19(27)14-5-7-22-18(10-14)26-8-6-17-15(12-26)11-23-20(21)25-17/h2-5,7,9-11H,6,8,12H2,1H3,(H,24,27)(H2,21,23,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236898
PNG
(US9388176, 119)
Show SMILES CSc1ncc2CN(CCc2n1)c1cc(ccn1)C(=O)Nc1cccc(c1)C(C)C
Show InChI InChI=1S/C23H25N5OS/c1-15(2)16-5-4-6-19(11-16)26-22(29)17-7-9-24-21(12-17)28-10-8-20-18(14-28)13-25-23(27-20)30-3/h4-7,9,11-13,15H,8,10,14H2,1-3H3,(H,26,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM236910
PNG
(US9388176, 157)
Show SMILES CSc1ncc2CN(CCc2n1)c1cncc(c1)C(=O)Nc1cccc(c1)C(C)C
Show InChI InChI=1S/C23H25N5OS/c1-15(2)16-5-4-6-19(9-16)26-22(29)17-10-20(13-24-11-17)28-8-7-21-18(14-28)12-25-23(27-21)30-3/h4-6,9-13,15H,7-8,14H2,1-3H3,(H,26,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139567
PNG
(US8889870, 36 | US9388176, 36)
Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C19H18N6O/c20-19-21-11-13-12-25(10-9-15(13)24-19)17-8-4-7-16(23-17)18(26)22-14-5-2-1-3-6-14/h1-8,11H,9-10,12H2,(H,22,26)(H2,20,21,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM139568
PNG
(US8889870, 37 | US9388176, 37)
Show SMILES Cc1cccc(NC(=O)c2cccc(n2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C20H20N6O/c1-13-4-2-5-15(10-13)23-19(27)17-6-3-7-18(24-17)26-9-8-16-14(12-26)11-22-20(21)25-16/h2-7,10-11H,8-9,12H2,1H3,(H,23,27)(H2,21,22,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%