BindingDB logo
myBDB logout

Patent code US9393232

Compile Data Set for Download or QSAR
Found 171 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 3 (BRD3)


(Homo sapiens (Human))
BDBM237471
PNG
(US9393232, 2.46)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@H](N)C3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H26N4O2/c1-15-22(16(2)30-27-15)17-10-11-21-20(13-17)24(23(29)26-21,18-7-4-3-5-8-18)28-12-6-9-19(25)14-28/h3-5,7-8,10-11,13,19H,6,9,12,14,25H2,1-2H3,(H,26,29)/t19-,24?/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.30n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 (BRD2)


(Homo sapiens (Human))
BDBM237471
PNG
(US9393232, 2.46)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@H](N)C3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H26N4O2/c1-15-22(16(2)30-27-15)17-10-11-21-20(13-17)24(23(29)26-21,18-7-4-3-5-8-18)28-12-6-9-19(25)14-28/h3-5,7-8,10-11,13,19H,6,9,12,14,25H2,1-2H3,(H,26,29)/t19-,24?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.60n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM50156344
PNG
(CHEMBL3787210)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@H](N)C3)(c3ccsc3)c2c1
Show InChI InChI=1S/C22H24N4O2S/c1-13-20(14(2)28-25-13)15-5-6-19-18(10-15)22(21(27)24-19,16-7-9-29-12-16)26-8-3-4-17(23)11-26/h5-7,9-10,12,17H,3-4,8,11,23H2,1-2H3,(H,24,27)/t17-,22?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 (BRD2)


(Homo sapiens (Human))
BDBM237443
PNG
(US9393232, 2.16)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@H](O)C3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O3/c1-15-22(16(2)30-26-15)17-10-11-21-20(13-17)24(23(29)25-21,18-7-4-3-5-8-18)27-12-6-9-19(28)14-27/h3-5,7-8,10-11,13,19,28H,6,9,12,14H2,1-2H3,(H,25,29)/t19-,24?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.60n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 3 (BRD3)


(Homo sapiens (Human))
BDBM237443
PNG
(US9393232, 2.16)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@H](O)C3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O3/c1-15-22(16(2)30-26-15)17-10-11-21-20(13-17)24(23(29)25-21,18-7-4-3-5-8-18)27-12-6-9-19(28)14-27/h3-5,7-8,10-11,13,19,28H,6,9,12,14H2,1-2H3,(H,25,29)/t19-,24?/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.90n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237471
PNG
(US9393232, 2.46)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@H](N)C3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H26N4O2/c1-15-22(16(2)30-27-15)17-10-11-21-20(13-17)24(23(29)26-21,18-7-4-3-5-8-18)28-12-6-9-19(25)14-28/h3-5,7-8,10-11,13,19H,6,9,12,14,25H2,1-2H3,(H,26,29)/t19-,24?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 3 (BRD3)


(Homo sapiens (Human))
BDBM237494
PNG
(US9393232, 4.1 | US9393232, 4.1a | US9393232, 4.1b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c3ccsc3)c2c1
Show InChI InChI=1S/C17H14N2O3S/c1-9-15(10(2)22-19-9)11-3-4-14-13(7-11)17(21,16(20)18-14)12-5-6-23-8-12/h3-8,21H,1-2H3,(H,18,20)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain testis-specific protein (BRDT)


(Homo sapiens (Human))
BDBM237471
PNG
(US9393232, 2.46)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@H](N)C3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H26N4O2/c1-15-22(16(2)30-27-15)17-10-11-21-20(13-17)24(23(29)26-21,18-7-4-3-5-8-18)28-12-6-9-19(25)14-28/h3-5,7-8,10-11,13,19H,6,9,12,14,25H2,1-2H3,(H,26,29)/t19-,24?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 (BRD2)


(Homo sapiens (Human))
BDBM237494
PNG
(US9393232, 4.1 | US9393232, 4.1a | US9393232, 4.1b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c3ccsc3)c2c1
Show InChI InChI=1S/C17H14N2O3S/c1-9-15(10(2)22-19-9)11-3-4-14-13(7-11)17(21,16(20)18-14)12-5-6-23-8-12/h3-8,21H,1-2H3,(H,18,20)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237502
PNG
(US9393232, 4.10b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@H](O)C3)(c3ccsc3)c2c1
Show InChI InChI=1S/C22H23N3O3S/c1-13-20(14(2)28-24-13)15-5-6-19-18(10-15)22(21(27)23-19,16-7-9-29-12-16)25-8-3-4-17(26)11-25/h5-7,9-10,12,17,26H,3-4,8,11H2,1-2H3,(H,23,27)/t17-,22?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237443
PNG
(US9393232, 2.16)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@H](O)C3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O3/c1-15-22(16(2)30-26-15)17-10-11-21-20(13-17)24(23(29)25-21,18-7-4-3-5-8-18)27-12-6-9-19(28)14-27/h3-5,7-8,10-11,13,19,28H,6,9,12,14H2,1-2H3,(H,25,29)/t19-,24?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 3 (BRD3)


(Homo sapiens (Human))
BDBM237521
PNG
(US9393232, 2.22)
Show SMILES C[C@@H](O)CNC1(C2CCCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C22H29N3O3/c1-13(26)12-23-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)24-21(22)27)20-14(2)25-28-15(20)3/h9-11,13,17,23,26H,4-8,12H2,1-3H3,(H,24,27)/t13-,22?/m1/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 23n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain testis-specific protein (BRDT)


(Homo sapiens (Human))
BDBM237443
PNG
(US9393232, 2.16)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@H](O)C3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O3/c1-15-22(16(2)30-26-15)17-10-11-21-20(13-17)24(23(29)25-21,18-7-4-3-5-8-18)27-12-6-9-19(28)14-27/h3-5,7-8,10-11,13,19,28H,6,9,12,14H2,1-2H3,(H,25,29)/t19-,24?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 23n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 3 (BRD3)


(Homo sapiens (Human))
BDBM237509
PNG
(US9393232, 2.10a | US9393232, 2.10b)
Show SMILES C[C@H](CO)NC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C22H23N3O3/c1-13(12-26)24-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)23-21(22)27)20-14(2)25-28-15(20)3/h4-11,13,24,26H,12H2,1-3H3,(H,23,27)/t13-,22?/m1/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 23n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM50156344
PNG
(CHEMBL3787210)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@H](N)C3)(c3ccsc3)c2c1
Show InChI InChI=1S/C22H24N4O2S/c1-13-20(14(2)28-25-13)15-5-6-19-18(10-15)22(21(27)24-19,16-7-9-29-12-16)26-8-3-4-17(23)11-26/h5-7,9-10,12,17H,3-4,8,11,23H2,1-2H3,(H,24,27)/t17-,22?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 24n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237533
PNG
(US9393232, 4.6a | US9393232, 4.6b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@@H](N)C3)(c3ccsc3)c2c1
Show InChI InChI=1S/C22H24N4O2S/c1-13-20(14(2)28-25-13)15-5-6-19-18(10-15)22(21(27)24-19,16-7-9-29-12-16)26-8-3-4-17(23)11-26/h5-7,9-10,12,17H,3-4,8,11,23H2,1-2H3,(H,24,27)/t17-,22?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237428
PNG
(US9393232, 2.2 | US9393232, 2.2a | US9393232, 2.2b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H17N3O2/c1-11-17(12(2)24-22-11)13-8-9-16-15(10-13)19(20,18(23)21-16)14-6-4-3-5-7-14/h3-10H,20H2,1-2H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 (BRD2)


(Homo sapiens (Human))
BDBM237509
PNG
(US9393232, 2.10a | US9393232, 2.10b)
Show SMILES C[C@H](CO)NC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C22H23N3O3/c1-13(12-26)24-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)23-21(22)27)20-14(2)25-28-15(20)3/h4-11,13,24,26H,12H2,1-3H3,(H,23,27)/t13-,22?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237499
PNG
(US9393232, 4.8)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCCC(O)C3)(c3ccsc3)c2c1
Show InChI InChI=1S/C22H23N3O3S/c1-13-20(14(2)28-24-13)15-5-6-19-18(10-15)22(21(27)23-19,16-7-9-29-12-16)25-8-3-4-17(26)11-25/h5-7,9-10,12,17,26H,3-4,8,11H2,1-2H3,(H,23,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237437
PNG
(US9393232, 2.9a | US9393232, 2.9b)
Show SMILES C[C@@H](CO)NC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C22H23N3O3/c1-13(12-26)24-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)23-21(22)27)20-14(2)25-28-15(20)3/h4-11,13,24,26H,12H2,1-3H3,(H,23,27)/t13-,22?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237498
PNG
(US9393232, 4.5)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC(O)CC3)(c3ccsc3)c2c1
Show InChI InChI=1S/C22H23N3O3S/c1-13-20(14(2)28-24-13)15-3-4-19-18(11-15)22(21(27)23-19,16-7-10-29-12-16)25-8-5-17(26)6-9-25/h3-4,7,10-12,17,26H,5-6,8-9H2,1-2H3,(H,23,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237500
PNG
(US9393232, 4.9a)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@@H](O)C3)(c3ccsc3)c2c1
Show InChI InChI=1S/C22H23N3O3S/c1-13-20(14(2)28-24-13)15-5-6-19-18(10-15)22(21(27)23-19,16-7-9-29-12-16)25-8-3-4-17(26)11-25/h5-7,9-10,12,17,26H,3-4,8,11H2,1-2H3,(H,23,27)/t17-,22?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 3 (BRD3)


(Homo sapiens (Human))
BDBM237422
PNG
(US9393232, 1.30a | US9393232, 1.30b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCCCC3=O)c2c1
Show InChI InChI=1S/C19H20N2O4/c1-10-17(11(2)25-21-10)12-7-8-15-14(9-12)19(24,18(23)20-15)13-5-3-4-6-16(13)22/h7-9,13,24H,3-6H2,1-2H3,(H,20,23)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237470
PNG
(US9393232, 2.45)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@@H](N)C3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H26N4O2/c1-15-22(16(2)30-27-15)17-10-11-21-20(13-17)24(23(29)26-21,18-7-4-3-5-8-18)28-12-6-9-19(25)14-28/h3-5,7-8,10-11,13,19H,6,9,12,14,25H2,1-2H3,(H,26,29)/t19-,24?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 26n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237501
PNG
(US9393232, 4.10a)
Show SMILES CC1=C(C(C)=[O]N1)c1ccc2NC(=O)C(N3CCC[C@H](O)C3)(c3ccsc3)c2c1
Show InChI InChI=1S/C22H24N3O3S/c1-13-20(14(2)28-24-13)15-5-6-19-18(10-15)22(21(27)23-19,16-7-9-29-12-16)25-8-3-4-17(26)11-25/h5-7,9-10,12,17,24,26H,3-4,8,11H2,1-2H3,(H,23,27)/t17-,22?/m0/s1
PDB

GoogleScholar
AffyNet 
PC sid
UniChem
US Patent
n/an/a 26n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237516
PNG
(US9393232, 2.17 | US9393232, 2.17a | US9393232, 2....)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@@H](O)C3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O3/c1-15-22(16(2)30-26-15)17-10-11-21-20(13-17)24(23(29)25-21,18-7-4-3-5-8-18)27-12-6-9-19(28)14-27/h3-5,7-8,10-11,13,19,28H,6,9,12,14H2,1-2H3,(H,25,29)/t19-,24?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 26n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237467
PNG
(US9393232, 2.42)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CC[C@@H](N)C3)(c2c1)c1ccccc1
Show InChI InChI=1S/C23H24N4O2/c1-14-21(15(2)29-26-14)16-8-9-20-19(12-16)23(22(28)25-20,17-6-4-3-5-7-17)27-11-10-18(24)13-27/h3-9,12,18H,10-11,13,24H2,1-2H3,(H,25,28)/t18-,23?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 27n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237516
PNG
(US9393232, 2.17 | US9393232, 2.17a | US9393232, 2....)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@@H](O)C3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O3/c1-15-22(16(2)30-26-15)17-10-11-21-20(13-17)24(23(29)25-21,18-7-4-3-5-8-18)27-12-6-9-19(28)14-27/h3-5,7-8,10-11,13,19,28H,6,9,12,14H2,1-2H3,(H,25,29)/t19-,24?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 27n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237533
PNG
(US9393232, 4.6a | US9393232, 4.6b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@@H](N)C3)(c3ccsc3)c2c1
Show InChI InChI=1S/C22H24N4O2S/c1-13-20(14(2)28-25-13)15-5-6-19-18(10-15)22(21(27)24-19,16-7-9-29-12-16)26-8-3-4-17(23)11-26/h5-7,9-10,12,17H,3-4,8,11,23H2,1-2H3,(H,24,27)/t17-,22?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain testis-specific protein (BRDT)


(Homo sapiens (Human))
BDBM237494
PNG
(US9393232, 4.1 | US9393232, 4.1a | US9393232, 4.1b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c3ccsc3)c2c1
Show InChI InChI=1S/C17H14N2O3S/c1-9-15(10(2)22-19-9)11-3-4-14-13(7-11)17(21,16(20)18-14)12-5-6-23-8-12/h3-8,21H,1-2H3,(H,18,20)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 31n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 (BRD2)


(Homo sapiens (Human))
BDBM237521
PNG
(US9393232, 2.22)
Show SMILES C[C@@H](O)CNC1(C2CCCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C22H29N3O3/c1-13(26)12-23-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)24-21(22)27)20-14(2)25-28-15(20)3/h9-11,13,17,23,26H,4-8,12H2,1-3H3,(H,24,27)/t13-,22?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 32n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237494
PNG
(US9393232, 4.1 | US9393232, 4.1a | US9393232, 4.1b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c3ccsc3)c2c1
Show InChI InChI=1S/C17H14N2O3S/c1-9-15(10(2)22-19-9)11-3-4-14-13(7-11)17(21,16(20)18-14)12-5-6-23-8-12/h3-8,21H,1-2H3,(H,18,20)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 34n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 3 (BRD3)


(Homo sapiens (Human))
BDBM237428
PNG
(US9393232, 2.2 | US9393232, 2.2a | US9393232, 2.2b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H17N3O2/c1-11-17(12(2)24-22-11)13-8-9-16-15(10-13)19(20,18(23)21-16)14-6-4-3-5-7-14/h3-10H,20H2,1-2H3,(H,21,23)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 35n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237391
PNG
(US9393232, 1.1 | US9393232, 1.1a | US9393232, 1.1b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H16N2O3/c1-11-17(12(2)24-21-11)13-8-9-16-15(10-13)19(23,18(22)20-16)14-6-4-3-5-7-14/h3-10,23H,1-2H3,(H,20,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 35n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237432
PNG
(US9393232, 2.4)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC(O)CC3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O3/c1-15-22(16(2)30-26-15)17-8-9-21-20(14-17)24(23(29)25-21,18-6-4-3-5-7-18)27-12-10-19(28)11-13-27/h3-9,14,19,28H,10-13H2,1-2H3,(H,25,29)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 36n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237482
PNG
(US9393232, 2.59 | US9393232, 2.59a | US9393232, 2....)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(c2c1)c1ccc(F)cc1
Show InChI InChI=1S/C19H16FN3O2/c1-10-17(11(2)25-23-10)12-3-8-16-15(9-12)19(21,18(24)22-16)13-4-6-14(20)7-5-13/h3-9H,21H2,1-2H3,(H,22,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 36n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237455
PNG
(US9393232, 2.31)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(C3CCCCC3)(N3CCC(O)CC3)c2c1
Show InChI InChI=1S/C24H31N3O3/c1-15-22(16(2)30-26-15)17-8-9-21-20(14-17)24(23(29)25-21,18-6-4-3-5-7-18)27-12-10-19(28)11-13-27/h8-9,14,18-19,28H,3-7,10-13H2,1-2H3,(H,25,29)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 37n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237535
PNG
(US9393232, 4.9b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)[C@](N3CCC[C@@H](O)C3)(c3ccsc3)c2c1
Show InChI InChI=1S/C22H23N3O3S/c1-13-20(14(2)28-24-13)15-5-6-19-18(10-15)22(21(27)23-19,16-7-9-29-12-16)25-8-3-4-17(26)11-25/h5-7,9-10,12,17,26H,3-4,8,11H2,1-2H3,(H,23,27)/t17-,22+/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 38n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237516
PNG
(US9393232, 2.17 | US9393232, 2.17a | US9393232, 2....)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@@H](O)C3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O3/c1-15-22(16(2)30-26-15)17-10-11-21-20(13-17)24(23(29)25-21,18-7-4-3-5-8-18)27-12-6-9-19(28)14-27/h3-5,7-8,10-11,13,19,28H,6,9,12,14H2,1-2H3,(H,25,29)/t19-,24?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237479
PNG
(US9393232, 2.57a | US9393232, 2.57b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N[C@H](CO)Cc3cnc[nH]3)(c2c1)c1ccccc1
Show InChI InChI=1S/C25H25N5O3/c1-15-23(16(2)33-30-15)17-8-9-22-21(10-17)25(24(32)28-22,18-6-4-3-5-7-18)29-20(13-31)11-19-12-26-14-27-19/h3-10,12,14,20,29,31H,11,13H2,1-2H3,(H,26,27)(H,28,32)/t20-,25?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 41n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain testis-specific protein (BRDT)


(Homo sapiens (Human))
BDBM237521
PNG
(US9393232, 2.22)
Show SMILES C[C@@H](O)CNC1(C2CCCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C22H29N3O3/c1-13(26)12-23-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)24-21(22)27)20-14(2)25-28-15(20)3/h9-11,13,17,23,26H,4-8,12H2,1-3H3,(H,24,27)/t13-,22?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 42n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237442
PNG
(US9393232, 2.15)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCCC(O)C3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O3/c1-15-22(16(2)30-26-15)17-10-11-21-20(13-17)24(23(29)25-21,18-7-4-3-5-8-18)27-12-6-9-19(28)14-27/h3-5,7-8,10-11,13,19,28H,6,9,12,14H2,1-2H3,(H,25,29)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 44n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237496
PNG
(US9393232, 4.3)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(NCCO)(c3ccsc3)c2c1
Show InChI InChI=1S/C19H19N3O3S/c1-11-17(12(2)25-22-11)13-3-4-16-15(9-13)19(18(24)21-16,20-6-7-23)14-5-8-26-10-14/h3-5,8-10,20,23H,6-7H2,1-2H3,(H,21,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 49n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237491
PNG
(US9393232, 3.8)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(CCCN3CCNCC3)(c2c1)c1ccccc1
Show InChI InChI=1S/C26H30N4O2/c1-18-24(19(2)32-29-18)20-9-10-23-22(17-20)26(25(31)28-23,21-7-4-3-5-8-21)11-6-14-30-15-12-27-13-16-30/h3-5,7-10,17,27H,6,11-16H2,1-2H3,(H,28,31)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 51n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237391
PNG
(US9393232, 1.1 | US9393232, 1.1a | US9393232, 1.1b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H16N2O3/c1-11-17(12(2)24-21-11)13-8-9-16-15(10-13)19(23,18(22)20-16)14-6-4-3-5-7-14/h3-10,23H,1-2H3,(H,20,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 51n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 (BRD2)


(Homo sapiens (Human))
BDBM237422
PNG
(US9393232, 1.30a | US9393232, 1.30b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCCCC3=O)c2c1
Show InChI InChI=1S/C19H20N2O4/c1-10-17(11(2)25-21-10)12-7-8-15-14(9-12)19(24,18(23)20-15)13-5-3-4-6-16(13)22/h7-9,13,24H,3-6H2,1-2H3,(H,20,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 52n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237485
PNG
(US9393232, 3.2)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(CCCO)(c2c1)c1ccccc1
Show InChI InChI=1S/C22H22N2O3/c1-14-20(15(2)27-24-14)16-9-10-19-18(13-16)22(11-6-12-25,21(26)23-19)17-7-4-3-5-8-17/h3-5,7-10,13,25H,6,11-12H2,1-2H3,(H,23,26)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 52n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237490
PNG
(US9393232, 3.7)
Show SMILES CN1CCN(CCCC2(C(=O)Nc3ccc(cc23)-c2c(C)noc2C)c2ccccc2)CC1
Show InChI InChI=1S/C27H32N4O2/c1-19-25(20(2)33-29-19)21-10-11-24-23(18-21)27(26(32)28-24,22-8-5-4-6-9-22)12-7-13-31-16-14-30(3)15-17-31/h4-6,8-11,18H,7,12-17H2,1-3H3,(H,28,32)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 53n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237461
PNG
(US9393232, 2.37 | US9393232, 2.37a | US9393232, 2....)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(C3CCCCC3)c2c1
Show InChI InChI=1S/C19H23N3O2/c1-11-17(12(2)24-22-11)13-8-9-16-15(10-13)19(20,18(23)21-16)14-6-4-3-5-7-14/h8-10,14H,3-7,20H2,1-2H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 54n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237472
PNG
(US9393232, 2.47)
Show SMILES CCOC(=O)CN1CCN(CC1)C1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C27H30N4O4/c1-4-34-24(32)17-30-12-14-31(15-13-30)27(21-8-6-5-7-9-21)22-16-20(10-11-23(22)28-26(27)33)25-18(2)29-35-19(25)3/h5-11,16H,4,12-15,17H2,1-3H3,(H,28,33)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 54n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 (BRD2)


(Homo sapiens (Human))
BDBM237428
PNG
(US9393232, 2.2 | US9393232, 2.2a | US9393232, 2.2b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H17N3O2/c1-11-17(12(2)24-22-11)13-8-9-16-15(10-13)19(20,18(23)21-16)14-6-4-3-5-7-14/h3-10H,20H2,1-2H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237509
PNG
(US9393232, 2.10a | US9393232, 2.10b)
Show SMILES C[C@H](CO)NC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C22H23N3O3/c1-13(12-26)24-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)23-21(22)27)20-14(2)25-28-15(20)3/h4-11,13,24,26H,12H2,1-3H3,(H,23,27)/t13-,22?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 57n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237423
PNG
(US9393232, 1.31)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(Cl)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H15ClN2O2/c1-11-17(12(2)24-22-11)13-8-9-16-15(10-13)19(20,18(23)21-16)14-6-4-3-5-7-14/h3-10H,1-2H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 58n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain testis-specific protein (BRDT)


(Homo sapiens (Human))
BDBM237422
PNG
(US9393232, 1.30a | US9393232, 1.30b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCCCC3=O)c2c1
Show InChI InChI=1S/C19H20N2O4/c1-10-17(11(2)25-21-10)12-7-8-15-14(9-12)19(24,18(23)20-15)13-5-3-4-6-16(13)22/h7-9,13,24H,3-6H2,1-2H3,(H,20,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 58n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237456
PNG
(US9393232, 2.32)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(C3CCCCC3)(N3CCCC(O)C3)c2c1
Show InChI InChI=1S/C24H31N3O3/c1-15-22(16(2)30-26-15)17-10-11-21-20(13-17)24(23(29)25-21,18-7-4-3-5-8-18)27-12-6-9-19(28)14-27/h10-11,13,18-19,28H,3-9,12,14H2,1-2H3,(H,25,29)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237454
PNG
(US9393232, 2.30)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(C3CCCCC3)(N3CCC[C@@H](O)C3)c2c1
Show InChI InChI=1S/C24H31N3O3/c1-15-22(16(2)30-26-15)17-10-11-21-20(13-17)24(23(29)25-21,18-7-4-3-5-8-18)27-12-6-9-19(28)14-27/h10-11,13,18-19,28H,3-9,12,14H2,1-2H3,(H,25,29)/t19-,24?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 61n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237434
PNG
(US9393232, 2.6)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCOCC3)(c2c1)c1ccccc1
Show InChI InChI=1S/C23H23N3O3/c1-15-21(16(2)29-25-15)17-8-9-20-19(14-17)23(22(27)24-20,18-6-4-3-5-7-18)26-10-12-28-13-11-26/h3-9,14H,10-13H2,1-2H3,(H,24,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 63n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237526
PNG
(US9393232, 2.51b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3C[C@H](O)C[C@@H]3CO)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O4/c1-14-22(15(2)31-26-14)16-8-9-21-20(10-16)24(23(30)25-21,17-6-4-3-5-7-17)27-12-19(29)11-18(27)13-28/h3-10,18-19,28-29H,11-13H2,1-2H3,(H,25,30)/t18-,19-,24?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 67n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain testis-specific protein (BRDT)


(Homo sapiens (Human))
BDBM237509
PNG
(US9393232, 2.10a | US9393232, 2.10b)
Show SMILES C[C@H](CO)NC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C22H23N3O3/c1-13(12-26)24-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)23-21(22)27)20-14(2)25-28-15(20)3/h4-11,13,24,26H,12H2,1-3H3,(H,23,27)/t13-,22?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 69n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237422
PNG
(US9393232, 1.30a | US9393232, 1.30b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCCCC3=O)c2c1
Show InChI InChI=1S/C19H20N2O4/c1-10-17(11(2)25-21-10)12-7-8-15-14(9-12)19(24,18(23)20-15)13-5-3-4-6-16(13)22/h7-9,13,24H,3-6H2,1-2H3,(H,20,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 70n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237427
PNG
(US9393232, 2.1)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(NCCO)(c2c1)c1ccccc1
Show InChI InChI=1S/C21H21N3O3/c1-13-19(14(2)27-24-13)15-8-9-18-17(12-15)21(20(26)23-18,22-10-11-25)16-6-4-3-5-7-16/h3-9,12,22,25H,10-11H2,1-2H3,(H,23,26)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 70n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237522
PNG
(US9393232, 2.24)
Show SMILES C[C@H](CO)NC1(C2CCCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C22H29N3O3/c1-13(12-26)24-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)23-21(22)27)20-14(2)25-28-15(20)3/h9-11,13,17,24,26H,4-8,12H2,1-3H3,(H,23,27)/t13-,22?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237465
PNG
(US9393232, 2.39)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(C3CCCCC3)(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H30N4O2/c1-15-21(16(2)29-26-15)17-8-9-20-19(14-17)23(22(28)25-20,18-6-4-3-5-7-18)27-12-10-24-11-13-27/h8-9,14,18,24H,3-7,10-13H2,1-2H3,(H,25,28)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 76n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237407
PNG
(US9393232, 1.15)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCCCC3)c2c1
Show InChI InChI=1S/C19H22N2O3/c1-11-17(12(2)24-21-11)13-8-9-16-15(10-13)19(23,18(22)20-16)14-6-4-3-5-7-14/h8-10,14,23H,3-7H2,1-2H3,(H,20,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 77n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237440
PNG
(US9393232, 2.14a)
Show SMILES C[C@@H](O)CNC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C22H23N3O3/c1-13(26)12-23-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)24-21(22)27)20-14(2)25-28-15(20)3/h4-11,13,23,26H,12H2,1-3H3,(H,24,27)/t13-,22?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 78n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237481
PNG
(US9393232, 2.58)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CC(O)C3)(c2c1)c1ccccc1
Show InChI InChI=1S/C22H21N3O3/c1-13-20(14(2)28-24-13)15-8-9-19-18(10-15)22(21(27)23-19,25-11-17(26)12-25)16-6-4-3-5-7-16/h3-10,17,26H,11-12H2,1-2H3,(H,23,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 78n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237424
PNG
(US9393232, 1.32)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(OCCO)(c2c1)c1ccccc1
Show InChI InChI=1S/C21H20N2O4/c1-13-19(14(2)27-23-13)15-8-9-18-17(12-15)21(20(25)22-18,26-11-10-24)16-6-4-3-5-7-16/h3-9,12,24H,10-11H2,1-2H3,(H,22,25)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 79n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237473
PNG
(US9393232, 2.48)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCN(CCO)CC3)(c2c1)c1ccccc1
Show InChI InChI=1S/C25H28N4O3/c1-17-23(18(2)32-27-17)19-8-9-22-21(16-19)25(24(31)26-22,20-6-4-3-5-7-20)29-12-10-28(11-13-29)14-15-30/h3-9,16,30H,10-15H2,1-2H3,(H,26,31)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 80n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237521
PNG
(US9393232, 2.22)
Show SMILES C[C@@H](O)CNC1(C2CCCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C22H29N3O3/c1-13(26)12-23-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)24-21(22)27)20-14(2)25-28-15(20)3/h9-11,13,17,23,26H,4-8,12H2,1-3H3,(H,24,27)/t13-,22?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 81n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237514
PNG
(US9393232, 2.13a | US9393232, 2.13b)
Show SMILES C[C@@H](O)CNC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C22H23N3O3/c1-13(26)12-23-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)24-21(22)27)20-14(2)25-28-15(20)3/h4-11,13,23,26H,12H2,1-3H3,(H,24,27)/t13-,22?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 81n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237425
PNG
(US9393232, 1.33)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(OCCO)(C3CCCCC3)c2c1
Show InChI InChI=1S/C21H26N2O4/c1-13-19(14(2)27-23-13)15-8-9-18-17(12-15)21(20(25)22-18,26-11-10-24)16-6-4-3-5-7-16/h8-9,12,16,24H,3-7,10-11H2,1-2H3,(H,22,25)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 82n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237474
PNG
(US9393232, 2.49)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCN(CCCO)CC3)(c2c1)c1ccccc1
Show InChI InChI=1S/C26H30N4O3/c1-18-24(19(2)33-28-18)20-9-10-23-22(17-20)26(25(32)27-23,21-7-4-3-5-8-21)30-14-12-29(13-15-30)11-6-16-31/h3-5,7-10,17,31H,6,11-16H2,1-2H3,(H,27,32)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 84n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237431
PNG
(US9393232, 2.3)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCCCC3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O2/c1-16-22(17(2)29-26-16)18-11-12-21-20(15-18)24(23(28)25-21,19-9-5-3-6-10-19)27-13-7-4-8-14-27/h3,5-6,9-12,15H,4,7-8,13-14H2,1-2H3,(H,25,28)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 84n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237451
PNG
(US9393232, 2.27)
Show SMILES CC(C)NC1(C2CCCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C22H29N3O2/c1-13(2)24-22(17-8-6-5-7-9-17)18-12-16(10-11-19(18)23-21(22)26)20-14(3)25-27-15(20)4/h10-13,17,24H,5-9H2,1-4H3,(H,23,26)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 85n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237444
PNG
(US9393232, 2.18)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(NCCO)(C3CCCCC3)c2c1
Show InChI InChI=1S/C21H27N3O3/c1-13-19(14(2)27-24-13)15-8-9-18-17(12-15)21(20(26)23-18,22-10-11-25)16-6-4-3-5-7-16/h8-9,12,16,22,25H,3-7,10-11H2,1-2H3,(H,23,26)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 85n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237447
PNG
(US9393232, 2.21)
Show SMILES C[C@H](O)CNC1(C2CCCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C22H29N3O3/c1-13(26)12-23-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)24-21(22)27)20-14(2)25-28-15(20)3/h9-11,13,17,23,26H,4-8,12H2,1-3H3,(H,24,27)/t13-,22?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 88n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237439
PNG
(US9393232, 2.12a)
Show SMILES CC(C)[C@@H](CO)NC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C24H27N3O3/c1-14(2)21(13-28)26-24(18-8-6-5-7-9-18)19-12-17(10-11-20(19)25-23(24)29)22-15(3)27-30-16(22)4/h5-12,14,21,26,28H,13H2,1-4H3,(H,25,29)/t21-,24?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 89n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237478
PNG
(US9393232, 2.57)
Show SMILES COC(=O)[C@H](Cc1cnc[nH]1)NC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C26H25N5O4/c1-15-23(16(2)35-31-15)17-9-10-21-20(11-17)26(25(33)29-21,18-7-5-4-6-8-18)30-22(24(32)34-3)12-19-13-27-14-28-19/h4-11,13-14,22,30H,12H2,1-3H3,(H,27,28)(H,29,33)/t22-,26?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237477
PNG
(US9393232, 2.53)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@H]3CO)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O3/c1-15-22(16(2)30-26-15)17-10-11-21-20(13-17)24(23(29)25-21,18-7-4-3-5-8-18)27-12-6-9-19(27)14-28/h3-5,7-8,10-11,13,19,28H,6,9,12,14H2,1-2H3,(H,25,29)/t19-,24?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237461
PNG
(US9393232, 2.37 | US9393232, 2.37a | US9393232, 2....)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(C3CCCCC3)c2c1
Show InChI InChI=1S/C19H23N3O2/c1-11-17(12(2)24-22-11)13-8-9-16-15(10-13)19(20,18(23)21-16)14-6-4-3-5-7-14/h8-10,14H,3-7,20H2,1-2H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 93n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237453
PNG
(US9393232, 2.29)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(C3CCCCC3)(N3CCOCC3)c2c1
Show InChI InChI=1S/C23H29N3O3/c1-15-21(16(2)29-25-15)17-8-9-20-19(14-17)23(22(27)24-20,18-6-4-3-5-7-18)26-10-12-28-13-11-26/h8-9,14,18H,3-7,10-13H2,1-2H3,(H,24,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 94n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain testis-specific protein (BRDT)


(Homo sapiens (Human))
BDBM237428
PNG
(US9393232, 2.2 | US9393232, 2.2a | US9393232, 2.2b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H17N3O2/c1-11-17(12(2)24-22-11)13-8-9-16-15(10-13)19(20,18(23)21-16)14-6-4-3-5-7-14/h3-10H,20H2,1-2H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 95n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237482
PNG
(US9393232, 2.59 | US9393232, 2.59a | US9393232, 2....)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(c2c1)c1ccc(F)cc1
Show InChI InChI=1S/C19H16FN3O2/c1-10-17(11(2)25-23-10)12-3-8-16-15(9-12)19(21,18(24)22-16)13-4-6-14(20)7-5-13/h3-9H,21H2,1-2H3,(H,22,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 97n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237406
PNG
(US9393232, 1.14)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCCCCC3)c2c1
Show InChI InChI=1S/C20H24N2O3/c1-12-18(13(2)25-22-12)14-9-10-17-16(11-14)20(24,19(23)21-17)15-7-5-3-4-6-8-15/h9-11,15,24H,3-8H2,1-2H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 98n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237396
PNG
(US9393232, 1.4)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccc(F)cc1
Show InChI InChI=1S/C19H15FN2O3/c1-10-17(11(2)25-22-10)12-3-8-16-15(9-12)19(24,18(23)21-16)13-4-6-14(20)7-5-13/h3-9,24H,1-2H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237494
PNG
(US9393232, 4.1 | US9393232, 4.1a | US9393232, 4.1b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c3ccsc3)c2c1
Show InChI InChI=1S/C17H14N2O3S/c1-9-15(10(2)22-19-9)11-3-4-14-13(7-11)17(21,16(20)18-14)12-5-6-23-8-12/h3-8,21H,1-2H3,(H,18,20)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237489
PNG
(US9393232, 3.6)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(CCCN3CCOCC3)(c2c1)c1ccccc1
Show InChI InChI=1S/C26H29N3O3/c1-18-24(19(2)32-28-18)20-9-10-23-22(17-20)26(25(30)27-23,21-7-4-3-5-8-21)11-6-12-29-13-15-31-16-14-29/h3-5,7-10,17H,6,11-16H2,1-2H3,(H,27,30)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237528
PNG
(US9393232, 2.55)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@@H]3CO)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O3/c1-15-22(16(2)30-26-15)17-10-11-21-20(13-17)24(23(29)25-21,18-7-4-3-5-8-18)27-12-6-9-19(27)14-28/h3-5,7-8,10-11,13,19,28H,6,9,12,14H2,1-2H3,(H,25,29)/t19-,24?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237433
PNG
(US9393232, 2.5)
Show SMILES CN1CCN(CC1)C1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C24H26N4O2/c1-16-22(17(2)30-26-16)18-9-10-21-20(15-18)24(23(29)25-21,19-7-5-4-6-8-19)28-13-11-27(3)12-14-28/h4-10,15H,11-14H2,1-3H3,(H,25,29)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237450
PNG
(US9393232, 2.26)
Show SMILES CN1CCN(CC1)C1(C2CCCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C24H32N4O2/c1-16-22(17(2)30-26-16)18-9-10-21-20(15-18)24(23(29)25-21,19-7-5-4-6-8-19)28-13-11-27(3)12-14-28/h9-10,15,19H,4-8,11-14H2,1-3H3,(H,25,29)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237484
PNG
(US9393232, 3.1)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(c2c1)c1ccccc1
Show InChI InChI=1S/C19H16N2O2/c1-11-17(12(2)23-21-11)14-8-9-16-15(10-14)18(19(22)20-16)13-6-4-3-5-7-13/h3-10,18H,1-2H3,(H,20,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237464
PNG
(US9393232, 2.38)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCNCC3)(c2c1)c1ccccc1
Show InChI InChI=1S/C23H24N4O2/c1-15-21(16(2)29-26-15)17-8-9-20-19(14-17)23(22(28)25-20,18-6-4-3-5-7-18)27-12-10-24-11-13-27/h3-9,14,24H,10-13H2,1-2H3,(H,25,28)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 120n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237492
PNG
(US9393232, 3.9)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(CCCN3CCC(O)CC3)(c2c1)c1ccccc1
Show InChI InChI=1S/C27H31N3O3/c1-18-25(19(2)33-29-18)20-9-10-24-23(17-20)27(26(32)28-24,21-7-4-3-5-8-21)13-6-14-30-15-11-22(31)12-16-30/h3-5,7-10,17,22,31H,6,11-16H2,1-2H3,(H,28,32)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 120n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237488
PNG
(US9393232, 3.5)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(CCO)(c2c1)c1ccccc1
Show InChI InChI=1S/C21H20N2O3/c1-13-19(14(2)26-23-13)15-8-9-18-17(12-15)21(10-11-24,20(25)22-18)16-6-4-3-5-7-16/h3-9,12,24H,10-11H2,1-2H3,(H,22,25)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 120n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237503
PNG
(US9393232, 4.11)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(c3ccsc3)c2c1
Show InChI InChI=1S/C17H14N2O2S/c1-9-15(10(2)21-19-9)11-3-4-14-13(7-11)16(17(20)18-14)12-5-6-22-8-12/h3-8,16H,1-2H3,(H,18,20)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 120n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237457
PNG
(US9393232, 2.33)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(C3CCCCC3)(N3CC(O)C3)c2c1
Show InChI InChI=1S/C22H27N3O3/c1-13-20(14(2)28-24-13)15-8-9-19-18(10-15)22(21(27)23-19,25-11-17(26)12-25)16-6-4-3-5-7-16/h8-10,16-17,26H,3-7,11-12H2,1-2H3,(H,23,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 120n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237458
PNG
(US9393232, 2.34)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(C3CCCC3)(N3CCOCC3)c2c1
Show InChI InChI=1S/C22H27N3O3/c1-14-20(15(2)28-24-14)16-7-8-19-18(13-16)22(21(26)23-19,17-5-3-4-6-17)25-9-11-27-12-10-25/h7-8,13,17H,3-6,9-12H2,1-2H3,(H,23,26)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 120n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237459
PNG
(US9393232, 2.35)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(NCCO)(C3CCCC3)c2c1
Show InChI InChI=1S/C20H25N3O3/c1-12-18(13(2)26-23-12)14-7-8-17-16(11-14)20(19(25)22-17,21-9-10-24)15-5-3-4-6-15/h7-8,11,15,21,24H,3-6,9-10H2,1-2H3,(H,22,25)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 130n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 3 (BRD3)


(Homo sapiens (Human))
BDBM237408
PNG
(US9393232, 1.16)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCOCC3)c2c1
Show InChI InChI=1S/C18H20N2O4/c1-10-16(11(2)24-20-10)12-3-4-15-14(9-12)18(22,17(21)19-15)13-5-7-23-8-6-13/h3-4,9,13,22H,5-8H2,1-2H3,(H,19,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 140n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237493
PNG
(US9393232, 3.10)
Show SMILES CN(C)CCCC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C24H27N3O2/c1-16-22(17(2)29-26-16)18-11-12-21-20(15-18)24(23(28)25-21,13-8-14-27(3)4)19-9-6-5-7-10-19/h5-7,9-12,15H,8,13-14H2,1-4H3,(H,25,28)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 140n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237452
PNG
(US9393232, 2.28)
Show SMILES CN(C)CCNC1(C2CCCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C23H32N4O2/c1-15-21(16(2)29-26-15)17-10-11-20-19(14-17)23(22(28)25-20,24-12-13-27(3)4)18-8-6-5-7-9-18/h10-11,14,18,24H,5-9,12-13H2,1-4H3,(H,25,28)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 140n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237511
PNG
(US9393232, 2.11a | US9393232, 2.11b)
Show SMILES CC(C)[C@H](CO)NC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C24H27N3O3/c1-14(2)21(13-28)26-24(18-8-6-5-7-9-18)19-12-17(10-11-20(19)25-23(24)29)22-15(3)27-30-16(22)4/h5-12,14,21,26,28H,13H2,1-4H3,(H,25,29)/t21-,24?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 150n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237466
PNG
(US9393232, 2.40)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(C3CCCC3)(N3CCNCC3)c2c1
Show InChI InChI=1S/C22H28N4O2/c1-14-20(15(2)28-25-14)16-7-8-19-18(13-16)22(21(27)24-19,17-5-3-4-6-17)26-11-9-23-10-12-26/h7-8,13,17,23H,3-6,9-12H2,1-2H3,(H,24,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 150n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237428
PNG
(US9393232, 2.2 | US9393232, 2.2a | US9393232, 2.2b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H17N3O2/c1-11-17(12(2)24-22-11)13-8-9-16-15(10-13)19(20,18(23)21-16)14-6-4-3-5-7-14/h3-10H,20H2,1-2H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 150n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237426
PNG
(US9393232, 1.34)
Show SMILES CC(=O)OC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C21H18N2O4/c1-12-19(13(2)27-23-12)15-9-10-18-17(11-15)21(20(25)22-18,26-14(3)24)16-7-5-4-6-8-16/h4-11H,1-3H3,(H,22,25)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 150n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237448
PNG
(US9393232, 2.23)
Show SMILES C[C@@H](CO)NC1(C2CCCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C22H29N3O3/c1-13(12-26)24-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)23-21(22)27)20-14(2)25-28-15(20)3/h9-11,13,17,24,26H,4-8,12H2,1-3H3,(H,23,27)/t13-,22?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 160n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237445
PNG
(US9393232, 2.19a | US9393232, 2.19b)
Show SMILES CC(C)[C@H](CO)NC1(C2CCCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C24H33N3O3/c1-14(2)21(13-28)26-24(18-8-6-5-7-9-18)19-12-17(10-11-20(19)25-23(24)29)22-15(3)27-30-16(22)4/h10-12,14,18,21,26,28H,5-9,13H2,1-4H3,(H,25,29)/t21-,24?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 170n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237460
PNG
(US9393232, 2.36)
Show SMILES CN1CCN(CC1)C1(C2CCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C23H30N4O2/c1-15-21(16(2)29-25-15)17-8-9-20-19(14-17)23(22(28)24-20,18-6-4-5-7-18)27-12-10-26(3)11-13-27/h8-9,14,18H,4-7,10-13H2,1-3H3,(H,24,28)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 180n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237397
PNG
(US9393232, 1.5)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccc(C)cc1
Show InChI InChI=1S/C20H18N2O3/c1-11-4-7-15(8-5-11)20(24)16-10-14(6-9-17(16)21-19(20)23)18-12(2)22-25-13(18)3/h4-10,24H,1-3H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 180n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237476
PNG
(US9393232, 2.52)
Show SMILES COC(=O)[C@@H]1CCCN1C1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C25H25N3O4/c1-15-22(16(2)32-27-15)17-11-12-20-19(14-17)25(24(30)26-20,18-8-5-4-6-9-18)28-13-7-10-21(28)23(29)31-3/h4-6,8-9,11-12,14,21H,7,10,13H2,1-3H3,(H,26,30)/t21-,25?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 190n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237400
PNG
(US9393232, 1.8)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C19H14F2N2O3/c1-9-17(10(2)26-23-9)11-3-6-16-13(7-11)19(25,18(24)22-16)12-4-5-14(20)15(21)8-12/h3-8,25H,1-2H3,(H,22,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237414
PNG
(US9393232, 1.22)
Show SMILES CC#CC1(O)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C16H14N2O3/c1-4-7-16(20)12-8-11(5-6-13(12)17-15(16)19)14-9(2)18-21-10(14)3/h5-6,8,20H,1-3H3,(H,17,19)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 220n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237527
PNG
(US9393232, 2.54)
Show SMILES COC(=O)[C@H]1CCCN1[C@]1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C25H25N3O4/c1-15-22(16(2)32-27-15)17-11-12-20-19(14-17)25(24(30)26-20,18-8-5-4-6-9-18)28-13-7-10-21(28)23(29)31-3/h4-6,8-9,11-12,14,21H,7,10,13H2,1-3H3,(H,26,30)/t21-,25-/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 220n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237394
PNG
(US9393232, 1.2)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H15ClN2O3/c1-10-17(11(2)25-22-10)12-3-8-16-15(9-12)19(24,18(23)21-16)13-4-6-14(20)7-5-13/h3-9,24H,1-2H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 260n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237529
PNG
(US9393232, 2.56)
Show SMILES COC(=O)[C@@H](Cc1cnc[nH]1)N[C@]1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C26H25N5O4/c1-15-23(16(2)35-31-15)17-9-10-21-20(11-17)26(25(33)29-21,18-7-5-4-6-8-18)30-22(24(32)34-3)12-19-13-27-14-28-19/h4-11,13-14,22,30H,12H2,1-3H3,(H,27,28)(H,29,33)/t22-,26-/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 260n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237409
PNG
(US9393232, 1.17)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCCC3)c2c1
Show InChI InChI=1S/C18H20N2O3/c1-10-16(11(2)23-20-10)12-7-8-15-14(9-12)18(22,17(21)19-15)13-5-3-4-6-13/h7-9,13,22H,3-6H2,1-2H3,(H,19,21)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 270n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237505
PNG
(US9393232, 6)
Show SMILES CN(C)CC(=O)NC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C23H24N4O3/c1-14-21(15(2)30-26-14)16-10-11-19-18(12-16)23(22(29)24-19,17-8-6-5-7-9-17)25-20(28)13-27(3)4/h5-12H,13H2,1-4H3,(H,24,29)(H,25,28)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 320n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237519
PNG
(US9393232, 2.20a | US9393232, 2.20b)
Show SMILES CC(C)[C@H](CO)NC1(C2CCCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C24H33N3O3/c1-14(2)21(13-28)26-24(18-8-6-5-7-9-18)19-12-17(10-11-20(19)25-23(24)29)22-15(3)27-30-16(22)4/h10-12,14,18,21,26,28H,5-9,13H2,1-4H3,(H,25,29)/t21-,24?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 350n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237509
PNG
(US9393232, 2.10a | US9393232, 2.10b)
Show SMILES C[C@H](CO)NC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C22H23N3O3/c1-13(12-26)24-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)23-21(22)27)20-14(2)25-28-15(20)3/h4-11,13,24,26H,12H2,1-3H3,(H,23,27)/t13-,22?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 370n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237398
PNG
(US9393232, 1.6)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccc(F)c(C)c1
Show InChI InChI=1S/C20H17FN2O3/c1-10-8-14(5-6-16(10)21)20(25)15-9-13(4-7-17(15)22-19(20)24)18-11(2)23-26-12(18)3/h4-9,25H,1-3H3,(H,22,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 380n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237395
PNG
(US9393232, 1.3)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1cccc(Cl)c1
Show InChI InChI=1S/C19H15ClN2O3/c1-10-17(11(2)25-22-10)12-6-7-16-15(8-12)19(24,18(23)21-16)13-4-3-5-14(20)9-13/h3-9,24H,1-2H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 380n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2 (BRD2)


(Homo sapiens (Human))
BDBM237408
PNG
(US9393232, 1.16)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCOCC3)c2c1
Show InChI InChI=1S/C18H20N2O4/c1-10-16(11(2)24-20-10)12-3-4-15-14(9-12)18(22,17(21)19-15)13-5-7-23-8-6-13/h3-4,9,13,22H,5-8H2,1-2H3,(H,19,21)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 380n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237497
PNG
(US9393232, 4.4)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(c3ccsc3)c2c1
Show InChI InChI=1S/C17H15N3O2S/c1-9-15(10(2)22-20-9)11-3-4-14-13(7-11)17(18,16(21)19-14)12-5-6-23-8-12/h3-8H,18H2,1-2H3,(H,19,21)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 400n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237479
PNG
(US9393232, 2.57a | US9393232, 2.57b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N[C@H](CO)Cc3cnc[nH]3)(c2c1)c1ccccc1
Show InChI InChI=1S/C25H25N5O3/c1-15-23(16(2)33-30-15)17-8-9-22-21(10-17)25(24(32)28-22,18-6-4-3-5-7-18)29-20(13-31)11-19-12-26-14-27-19/h3-10,12,14,20,29,31H,11,13H2,1-2H3,(H,26,27)(H,28,32)/t20-,25?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 410n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237401
PNG
(US9393232, 1.9)
Show SMILES COc1ccc(cc1)C1(O)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C20H18N2O4/c1-11-18(12(2)26-22-11)13-4-9-17-16(10-13)20(24,19(23)21-17)14-5-7-15(25-3)8-6-14/h4-10,24H,1-3H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 410n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237416
PNG
(US9393232, 1.24)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(CCC=C)c2c1
Show InChI InChI=1S/C17H18N2O3/c1-4-5-8-17(21)13-9-12(6-7-14(13)18-16(17)20)15-10(2)19-22-11(15)3/h4,6-7,9,21H,1,5,8H2,2-3H3,(H,18,20)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 430n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237486
PNG
(US9393232, 3.3)
Show SMILES CCOC(=O)CC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C23H22N2O4/c1-4-28-20(26)13-23(17-8-6-5-7-9-17)18-12-16(10-11-19(18)24-22(23)27)21-14(2)25-29-15(21)3/h5-12H,4,13H2,1-3H3,(H,24,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 440n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237523
PNG
(US9393232, 2.41)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CC[C@H](C3)NC(=O)OC(C)(C)C)(c2c1)c1ccccc1
Show InChI InChI=1S/C28H32N4O4/c1-17-24(18(2)36-31-17)19-11-12-23-22(15-19)28(25(33)30-23,20-9-7-6-8-10-20)32-14-13-21(16-32)29-26(34)35-27(3,4)5/h6-12,15,21H,13-14,16H2,1-5H3,(H,29,34)(H,30,33)/t21-,28?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 440n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237504
PNG
(US9393232, 5.1)
Show SMILES COc1cc(cc2c1NC(=O)C2(O)c1ccccc1)-c1c(C)noc1C
Show InChI InChI=1S/C20H18N2O4/c1-11-17(12(2)26-22-11)13-9-15-18(16(10-13)25-3)21-19(23)20(15,24)14-7-5-4-6-8-14/h4-10,24H,1-3H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 450n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237524
PNG
(US9393232, 2.50a)
Show SMILES COC(=O)[C@@H]1C[C@H](O)CN1C1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C25H25N3O5/c1-14-22(15(2)33-27-14)16-9-10-20-19(11-16)25(24(31)26-20,17-7-5-4-6-8-17)28-13-18(29)12-21(28)23(30)32-3/h4-11,18,21,29H,12-13H2,1-3H3,(H,26,31)/t18-,21-,25?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 460n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237435
PNG
(US9393232, 2.8a | US9393232, 2.8b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N[C@H](CO)c3ccccc3)(c2c1)c1ccccc1
Show InChI InChI=1S/C27H25N3O3/c1-17-25(18(2)33-30-17)20-13-14-23-22(15-20)27(26(32)28-23,21-11-7-4-8-12-21)29-24(16-31)19-9-5-3-6-10-19/h3-15,24,29,31H,16H2,1-2H3,(H,28,32)/t24-,27?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 510n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain testis-specific protein (BRDT)


(Homo sapiens (Human))
BDBM237408
PNG
(US9393232, 1.16)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCOCC3)c2c1
Show InChI InChI=1S/C18H20N2O4/c1-10-16(11(2)24-20-10)12-3-4-15-14(9-12)18(22,17(21)19-15)13-5-7-23-8-6-13/h3-4,9,13,22H,5-8H2,1-2H3,(H,19,21)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 510n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237410
PNG
(US9393232, 1.18)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCC3)c2c1
Show InChI InChI=1S/C17H18N2O3/c1-9-15(10(2)22-19-9)11-6-7-14-13(8-11)17(21,16(20)18-14)12-4-3-5-12/h6-8,12,21H,3-5H2,1-2H3,(H,18,20)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 510n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237468
PNG
(US9393232, 2.43)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@H](C3)NC(=O)OC(C)(C)C)(c2c1)c1ccccc1
Show InChI InChI=1S/C29H34N4O4/c1-18-25(19(2)37-32-18)20-13-14-24-23(16-20)29(26(34)31-24,21-10-7-6-8-11-21)33-15-9-12-22(17-33)30-27(35)36-28(3,4)5/h6-8,10-11,13-14,16,22H,9,12,15,17H2,1-5H3,(H,30,35)(H,31,34)/t22-,29?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 510n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237417
PNG
(US9393232, 1.25)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(CCCC=C)c2c1
Show InChI InChI=1S/C18H20N2O3/c1-4-5-6-9-18(22)14-10-13(7-8-15(14)19-17(18)21)16-11(2)20-23-12(16)3/h4,7-8,10,22H,1,5-6,9H2,2-3H3,(H,19,21)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 540n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237405
PNG
(US9393232, 1.13)
Show SMILES Cc1ccsc1C1(O)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C18H16N2O3S/c1-9-6-7-24-16(9)18(22)13-8-12(4-5-14(13)19-17(18)21)15-10(2)20-23-11(15)3/h4-8,22H,1-3H3,(H,19,21)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 560n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237399
PNG
(US9393232, 1.7)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccccc1C
Show InChI InChI=1S/C20H18N2O3/c1-11-6-4-5-7-15(11)20(24)16-10-14(8-9-17(16)21-19(20)23)18-12(2)22-25-13(18)3/h4-10,24H,1-3H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 570n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237441
PNG
(US9393232, 2.14b)
Show SMILES C[C@H](O)CNC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C22H23N3O3/c1-13(26)12-23-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)24-21(22)27)20-14(2)25-28-15(20)3/h4-11,13,23,26H,12H2,1-3H3,(H,24,27)/t13-,22?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 610n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237408
PNG
(US9393232, 1.16)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCOCC3)c2c1
Show InChI InChI=1S/C18H20N2O4/c1-10-16(11(2)24-20-10)12-3-4-15-14(9-12)18(22,17(21)19-15)13-5-7-23-8-6-13/h3-4,9,13,22H,5-8H2,1-2H3,(H,19,21)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 630n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237422
PNG
(US9393232, 1.30a | US9393232, 1.30b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCCCC3=O)c2c1
Show InChI InChI=1S/C19H20N2O4/c1-10-17(11(2)25-21-10)12-7-8-15-14(9-12)19(24,18(23)20-15)13-5-3-4-6-16(13)22/h7-9,13,24H,3-6H2,1-2H3,(H,20,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237532
PNG
(US9393232, 4.2)
Show SMILES CC(=O)CC1(O)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C16H16N2O4/c1-8(19)7-16(21)12-6-11(4-5-13(12)17-15(16)20)14-9(2)18-22-10(14)3/h4-6,21H,7H2,1-3H3,(H,17,20)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 670n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237514
PNG
(US9393232, 2.13a | US9393232, 2.13b)
Show SMILES C[C@@H](O)CNC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C22H23N3O3/c1-13(26)12-23-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)24-21(22)27)20-14(2)25-28-15(20)3/h4-11,13,23,26H,12H2,1-3H3,(H,24,27)/t13-,22?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 710n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237507
PNG
(US9393232, 2.7a | US9393232, 2.7b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N[C@@H](CO)c3ccccc3)(c2c1)c1ccccc1
Show InChI InChI=1S/C27H25N3O3/c1-17-25(18(2)33-30-17)20-13-14-23-22(15-20)27(26(32)28-23,21-11-7-4-8-12-21)29-24(16-31)19-9-5-3-6-10-19/h3-15,24,29,31H,16H2,1-2H3,(H,28,32)/t24-,27?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 810n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237411
PNG
(US9393232, 1.19)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CC3)c2c1
Show InChI InChI=1S/C16H16N2O3/c1-8-14(9(2)21-18-8)10-3-6-13-12(7-10)16(20,11-4-5-11)15(19)17-13/h3,6-7,11,20H,4-5H2,1-2H3,(H,17,19)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 850n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237525
PNG
(US9393232, 2.50b)
Show SMILES COC(=O)[C@@H]1C[C@@H](O)CN1C1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C25H25N3O5/c1-14-22(15(2)33-27-14)16-9-10-20-19(11-16)25(24(31)26-20,17-7-5-4-6-8-17)28-13-18(29)12-21(28)23(30)32-3/h4-11,18,21,29H,12-13H2,1-3H3,(H,26,31)/t18-,21+,25?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 850n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237437
PNG
(US9393232, 2.9a | US9393232, 2.9b)
Show SMILES C[C@@H](CO)NC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C22H23N3O3/c1-13(12-26)24-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)23-21(22)27)20-14(2)25-28-15(20)3/h4-11,13,24,26H,12H2,1-3H3,(H,23,27)/t13-,22?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 860n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237469
PNG
(US9393232, 2.44)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@@H](C3)NC(=O)OC(C)(C)C)(c2c1)c1ccccc1
Show InChI InChI=1S/C29H34N4O4/c1-18-25(19(2)37-32-18)20-13-14-24-23(16-20)29(26(34)31-24,21-10-7-6-8-11-21)33-15-9-12-22(17-33)30-27(35)36-28(3,4)5/h6-8,10-11,13-14,16,22H,9,12,15,17H2,1-5H3,(H,30,35)(H,31,34)/t22-,29?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237461
PNG
(US9393232, 2.37 | US9393232, 2.37a | US9393232, 2....)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(C3CCCCC3)c2c1
Show InChI InChI=1S/C19H23N3O2/c1-11-17(12(2)24-22-11)13-8-9-16-15(10-13)19(20,18(23)21-16)14-6-4-3-5-7-14/h8-10,14H,3-7,20H2,1-2H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237413
PNG
(US9393232, 1.21)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C#C)c2c1
Show InChI InChI=1S/C15H12N2O3/c1-4-15(19)11-7-10(5-6-12(11)16-14(15)18)13-8(2)17-20-9(13)3/h1,5-7,19H,2-3H3,(H,16,18)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237402
PNG
(US9393232, 1.10)
Show SMILES COc1ccc(cc1OC)C1(O)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C21H20N2O5/c1-11-19(12(2)28-23-11)13-5-7-16-15(9-13)21(25,20(24)22-16)14-6-8-17(26-3)18(10-14)27-4/h5-10,25H,1-4H3,(H,22,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237475
PNG
(US9393232, 2.51a)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3C[C@@H](O)C[C@H]3CO)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O4/c1-14-22(15(2)31-26-14)16-8-9-21-20(10-16)24(23(30)25-21,17-6-4-3-5-7-17)27-12-19(29)11-18(27)13-28/h3-10,18-19,28-29H,11-13H2,1-2H3,(H,25,30)/t18-,19-,24?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237421
PNG
(US9393232, 1.29)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(CCCc3ccccc3)c2c1
Show InChI InChI=1S/C22H22N2O3/c1-14-20(15(2)27-24-14)17-10-11-19-18(13-17)22(26,21(25)23-19)12-6-9-16-7-4-3-5-8-16/h3-5,7-8,10-11,13,26H,6,9,12H2,1-2H3,(H,23,25)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237435
PNG
(US9393232, 2.8a | US9393232, 2.8b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N[C@H](CO)c3ccccc3)(c2c1)c1ccccc1
Show InChI InChI=1S/C27H25N3O3/c1-17-25(18(2)33-30-17)20-13-14-23-22(15-20)27(26(32)28-23,21-11-7-4-8-12-21)29-24(16-31)19-9-5-3-6-10-19/h3-15,24,29,31H,16H2,1-2H3,(H,28,32)/t24-,27?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.20E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237412
PNG
(US9393232, 1.20)
Show SMILES CCC1(O)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C15H16N2O3/c1-4-15(19)11-7-10(5-6-12(11)16-14(15)18)13-8(2)17-20-9(13)3/h5-7,19H,4H2,1-3H3,(H,16,18)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.30E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237404
PNG
(US9393232, 1.12)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C#Cc3ccccc3)c2c1
Show InChI InChI=1S/C21H16N2O3/c1-13-19(14(2)26-23-13)16-8-9-18-17(12-16)21(25,20(24)22-18)11-10-15-6-4-3-5-7-15/h3-9,12,25H,1-2H3,(H,22,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.30E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237403
PNG
(US9393232, 1.11)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1cccc2ccccc12
Show InChI InChI=1S/C23H18N2O3/c1-13-21(14(2)28-25-13)16-10-11-20-19(12-16)23(27,22(26)24-20)18-9-5-7-15-6-3-4-8-17(15)18/h3-12,27H,1-2H3,(H,24,26)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.50E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237415
PNG
(US9393232, 1.23)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(CC=C)c2c1
Show InChI InChI=1S/C16H16N2O3/c1-4-7-16(20)12-8-11(5-6-13(12)17-15(16)19)14-9(2)18-21-10(14)3/h4-6,8,20H,1,7H2,2-3H3,(H,17,19)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.50E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237419
PNG
(US9393232, 1.27)
Show SMILES CC(C)C1(O)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C16H18N2O3/c1-8(2)16(20)12-7-11(5-6-13(12)17-15(16)19)14-9(3)18-21-10(14)4/h5-8,20H,1-4H3,(H,17,19)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.80E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237418
PNG
(US9393232, 1.26)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)C(C)(C)C
Show InChI InChI=1S/C17H20N2O3/c1-9-14(10(2)22-19-9)11-6-7-13-12(8-11)17(21,15(20)18-13)16(3,4)5/h6-8,21H,1-5H3,(H,18,20)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.20E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237513
PNG
(US9393232, 2.12b)
Show SMILES CC(C)[C@@H](CO)NC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C24H27N3O3/c1-14(2)21(13-28)26-24(18-8-6-5-7-9-18)19-12-17(10-11-20(19)25-23(24)29)22-15(3)27-30-16(22)4/h5-12,14,21,26,28H,13H2,1-4H3,(H,25,29)/t21-,24?/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.40E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237511
PNG
(US9393232, 2.11a | US9393232, 2.11b)
Show SMILES CC(C)[C@H](CO)NC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C24H27N3O3/c1-14(2)21(13-28)26-24(18-8-6-5-7-9-18)19-12-17(10-11-20(19)25-23(24)29)22-15(3)27-30-16(22)4/h5-12,14,21,26,28H,13H2,1-4H3,(H,25,29)/t21-,24?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.60E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237428
PNG
(US9393232, 2.2 | US9393232, 2.2a | US9393232, 2.2b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H17N3O2/c1-11-17(12(2)24-22-11)13-8-9-16-15(10-13)19(20,18(23)21-16)14-6-4-3-5-7-14/h3-10H,20H2,1-2H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.60E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237449
PNG
(US9393232, 2.25)
Show SMILES CC(C)CCNC1(C2CCCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C24H33N3O2/c1-15(2)12-13-25-24(19-8-6-5-7-9-19)20-14-18(10-11-21(20)26-23(24)28)22-16(3)27-29-17(22)4/h10-11,14-15,19,25H,5-9,12-13H2,1-4H3,(H,26,28)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.70E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237420
PNG
(US9393232, 1.28)
Show SMILES CC(=C)CC1(O)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C17H18N2O3/c1-9(2)8-17(21)13-7-12(5-6-14(13)18-16(17)20)15-10(3)19-22-11(15)4/h5-7,21H,1,8H2,2-4H3,(H,18,20)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.90E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237482
PNG
(US9393232, 2.59 | US9393232, 2.59a | US9393232, 2....)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(c2c1)c1ccc(F)cc1
Show InChI InChI=1S/C19H16FN3O2/c1-10-17(11(2)25-23-10)12-3-8-16-15(9-12)19(21,18(24)22-16)13-4-6-14(20)7-5-13/h3-9H,21H2,1-2H3,(H,22,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.10E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237494
PNG
(US9393232, 4.1 | US9393232, 4.1a | US9393232, 4.1b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c3ccsc3)c2c1
Show InChI InChI=1S/C17H14N2O3S/c1-9-15(10(2)22-19-9)11-3-4-14-13(7-11)17(21,16(20)18-14)12-5-6-23-8-12/h3-8,21H,1-2H3,(H,18,20)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.90E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237519
PNG
(US9393232, 2.20a | US9393232, 2.20b)
Show SMILES CC(C)[C@H](CO)NC1(C2CCCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C24H33N3O3/c1-14(2)21(13-28)26-24(18-8-6-5-7-9-18)19-12-17(10-11-20(19)25-23(24)29)22-15(3)27-30-16(22)4/h10-12,14,18,21,26,28H,5-9,13H2,1-4H3,(H,25,29)/t21-,24?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.10E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237487
PNG
(US9393232, 3.4)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(CC(O)=O)(c2c1)c1ccccc1
Show InChI InChI=1S/C21H18N2O4/c1-12-19(13(2)27-23-12)14-8-9-17-16(10-14)21(11-18(24)25,20(26)22-17)15-6-4-3-5-7-15/h3-10H,11H2,1-2H3,(H,22,26)(H,24,25)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.10E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237391
PNG
(US9393232, 1.1 | US9393232, 1.1a | US9393232, 1.1b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H16N2O3/c1-11-17(12(2)24-21-11)13-8-9-16-15(10-13)19(23,18(22)20-16)14-6-4-3-5-7-14/h3-10,23H,1-2H3,(H,20,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.00E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237507
PNG
(US9393232, 2.7a | US9393232, 2.7b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N[C@@H](CO)c3ccccc3)(c2c1)c1ccccc1
Show InChI InChI=1S/C27H25N3O3/c1-17-25(18(2)33-30-17)20-13-14-23-22(15-20)27(26(32)28-23,21-11-7-4-8-12-21)29-24(16-31)19-9-5-3-6-10-19/h3-15,24,29,31H,16H2,1-2H3,(H,28,32)/t24-,27?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM237445
PNG
(US9393232, 2.19a | US9393232, 2.19b)
Show SMILES CC(C)[C@H](CO)NC1(C2CCCCC2)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C24H33N3O3/c1-14(2)21(13-28)26-24(18-8-6-5-7-9-18)19-12-17(10-11-20(19)25-23(24)29)22-15(3)27-30-16(22)4/h10-12,14,18,21,26,28H,5-9,13H2,1-4H3,(H,25,29)/t21-,24?/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%