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Patent code US9394250

Compile Data Set for Download or QSAR
Found 56 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor XI


(Homo sapiens (human))
BDBM238267
PNG
(US9394250, 99)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CCC(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C28H39ClN8O5S/c1-42-28(39)32-20-9-7-17(8-10-20)23-24(29)34-26(33-23)22-15-21(35-11-13-36(14-12-35)43(2,40)41)16-37(22)27(38)19-5-3-18(4-6-19)25(30)31/h7-10,18-19,21-22H,3-6,11-16H2,1-2H3,(H3,30,31)(H,32,39)(H,33,34)/t18?,19?,21-,22-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238259
PNG
(US9394250, 71)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C28H39ClN8O5S/c1-42-28(39)32-21-5-3-18(4-6-21)23-24(29)34-25(33-23)22-15-20(17-9-13-36(14-10-17)43(2,40)41)16-37(22)26(38)19-7-11-35(12-8-19)27(30)31/h3-6,17,19-20,22H,7-16H2,1-2H3,(H3,30,31)(H,32,39)(H,33,34)/t20-,22-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238268
PNG
(US9394250, 98)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C27H39N9O5S/c1-41-27(38)31-20-5-3-18(4-6-20)22-16-30-24(32-22)23-15-21(33-11-13-35(14-12-33)42(2,39)40)17-36(23)25(37)19-7-9-34(10-8-19)26(28)29/h3-6,16,19,21,23H,7-15,17H2,1-2H3,(H3,28,29)(H,30,32)(H,31,38)/t21-,23-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238252
PNG
(US9394250, 20)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@H]1C[C@H](N(C1)C(=O)c1ccc(cc1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H30N6O6S/c1-38(36,37)30-12-10-29(11-13-30)20-14-21(23(32)28-19-8-6-18(7-9-19)25(34)35)31(15-20)24(33)17-4-2-16(3-5-17)22(26)27/h2-9,20-21H,10-15H2,1H3,(H3,26,27)(H,28,32)(H,34,35)/t20-,21-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238266
PNG
(US9394250, 96)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)[C@H]1CC[C@H](CN)CC1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C29H41ClN6O5S/c1-41-29(38)32-23-9-7-20(8-10-23)25-26(30)34-27(33-25)24-15-22(19-11-13-35(14-12-19)42(2,39)40)17-36(24)28(37)21-5-3-18(16-31)4-6-21/h7-10,18-19,21-22,24H,3-6,11-17,31H2,1-2H3,(H,32,38)(H,33,34)/t18-,21-,22-,24-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238260
PNG
(US9394250, 73)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)c1ccc(cc1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C29H35N7O5S/c1-41-29(38)33-23-9-7-19(8-10-23)24-16-32-27(34-24)25-15-22(18-11-13-35(14-12-18)42(2,39)40)17-36(25)28(37)21-5-3-20(4-6-21)26(30)31/h3-10,16,18,22,25H,11-15,17H2,1-2H3,(H3,30,31)(H,32,34)(H,33,38)/t22-,25-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238265
PNG
(US9394250, 94)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C31H33Cl2N9O5S/c1-47-31(44)35-24-7-3-20(4-8-24)28-29(33)37-30(36-28)26-16-22(19-11-13-40(14-12-19)48(2,45)46)17-41(26)27(43)10-5-21-15-23(32)6-9-25(21)42-18-34-38-39-42/h3-10,15,18-19,22,26H,11-14,16-17H2,1-2H3,(H,35,44)(H,36,37)/b10-5+/t22-,26-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238263
PNG
(US9394250, 88)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)N1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C27H38ClN9O5S/c1-42-26(38)31-20-5-3-18(4-6-20)22-23(28)33-24(32-22)21-15-19(17-7-9-36(10-8-17)43(2,40)41)16-37(21)27(39)35-13-11-34(12-14-35)25(29)30/h3-6,17,19,21H,7-16H2,1-2H3,(H3,29,30)(H,31,38)(H,32,33)/t19-,21-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238261
PNG
(US9394250, 79)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)c1ccc(NC(N)=N)cc1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C29H35ClN8O5S/c1-43-29(40)34-22-7-3-18(4-8-22)24-25(30)36-26(35-24)23-15-20(17-11-13-37(14-12-17)44(2,41)42)16-38(23)27(39)19-5-9-21(10-6-19)33-28(31)32/h3-10,17,20,23H,11-16H2,1-2H3,(H,34,40)(H,35,36)(H4,31,32,33)/t20-,23-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238258
PNG
(US9394250, 69)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C28H40N8O5S/c1-41-28(38)32-22-5-3-19(4-6-22)23-16-31-25(33-23)24-15-21(18-9-13-35(14-10-18)42(2,39)40)17-36(24)26(37)20-7-11-34(12-8-20)27(29)30/h3-6,16,18,20-21,24H,7-15,17H2,1-2H3,(H3,29,30)(H,31,33)(H,32,38)/t21-,24-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238269
PNG
(US9394250, 111)
Show SMILES CS(=O)(=O)N1CCC(CC1)[C@H]1C[C@H](N(C1)C(=O)c1ccc(cc1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H31N5O6S/c1-38(36,37)30-12-10-16(11-13-30)20-14-22(24(32)29-21-8-6-19(7-9-21)26(34)35)31(15-20)25(33)18-4-2-17(3-5-18)23(27)28/h2-9,16,20,22H,10-15H2,1H3,(H3,27,28)(H,29,32)(H,34,35)/t20-,22-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238262
PNG
(US9394250, 86)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)[C@H]1CCC(CC1)[C@H](C)N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C30H43ClN6O5S/c1-18(32)19-4-6-22(7-5-19)29(38)37-17-23(20-12-14-36(15-13-20)43(3,40)41)16-25(37)28-34-26(27(31)35-28)21-8-10-24(11-9-21)33-30(39)42-2/h8-11,18-20,22-23,25H,4-7,12-17,32H2,1-3H3,(H,33,39)(H,34,35)/t18-,19?,22-,23-,25-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238255
PNG
(US9394250, 43)
Show SMILES Clc1ccc(c(\C=C\C(=O)N2C[C@H](C[C@H]2C(=O)Nc2ccc3nn[nH]c3c2)N2CCOCC2)c1)-n1cnnn1
Show InChI InChI=1S/C25H25ClN10O3/c26-17-2-5-22(36-15-27-31-33-36)16(11-17)1-6-24(37)35-14-19(34-7-9-39-10-8-34)13-23(35)25(38)28-18-3-4-20-21(12-18)30-32-29-20/h1-6,11-12,15,19,23H,7-10,13-14H2,(H,28,38)(H,29,30,32)/b6-1+/t19-,23-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238253
PNG
(US9394250, 37)
Show SMILES OC(=O)c1ccc(NC(=O)[C@@H]2C[C@@H](CN2C(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)N2CCOCC2)cc1
Show InChI InChI=1S/C26H26ClN7O5/c27-19-4-7-22(34-16-28-30-31-34)18(13-19)3-8-24(35)33-15-21(32-9-11-39-12-10-32)14-23(33)25(36)29-20-5-1-17(2-6-20)26(37)38/h1-8,13,16,21,23H,9-12,14-15H2,(H,29,36)(H,37,38)/b8-3+/t21-,23-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238256
PNG
(US9394250, 55)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(cc1)C(O)=O)N1CCN(CC1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C27H39N5O6S/c28-16-18-1-3-19(4-2-18)26(34)32-17-22(30-11-13-31(14-12-30)39(37,38)23-9-10-23)15-24(32)25(33)29-21-7-5-20(6-8-21)27(35)36/h5-8,18-19,22-24H,1-4,9-17,28H2,(H,29,33)(H,35,36)/t18-,19-,22-,24-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238251
PNG
(US9394250, 9)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@H]1C[C@H](N(C1)C(=O)C1CCN(CC1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H35N7O6S/c1-38(36,37)30-12-10-28(11-13-30)19-14-20(21(32)27-18-4-2-17(3-5-18)23(34)35)31(15-19)22(33)16-6-8-29(9-7-16)24(25)26/h2-5,16,19-20H,6-15H2,1H3,(H3,25,26)(H,27,32)(H,34,35)/t19-,20-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238264
PNG
(US9394250, 93)
Show SMILES Cn1cc(Cl)c2c(F)c(ccc12)C(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(cc1)C(O)=O)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C28H30ClFN4O6S/c1-32-15-21(29)24-22(32)8-7-20(25(24)30)27(36)34-14-18(16-9-11-33(12-10-16)41(2,39)40)13-23(34)26(35)31-19-5-3-17(4-6-19)28(37)38/h3-8,15-16,18,23H,9-14H2,1-2H3,(H,31,35)(H,37,38)/t18-,23-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238257
PNG
(US9394250, 57)
Show SMILES C[C@H]1CN(CCN1S(N)(=O)=O)[C@H]1C[C@H](N(C1)C(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C26H30ClN9O4S/c1-18-15-33(11-12-36(18)41(28,39)40)22-14-24(26(38)30-21-5-3-2-4-6-21)34(16-22)25(37)10-7-19-13-20(27)8-9-23(19)35-17-29-31-32-35/h2-10,13,17-18,22,24H,11-12,14-16H2,1H3,(H,30,38)(H2,28,39,40)/b10-7+/t18-,22-,24-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM238254
PNG
(US9394250, 39)
Show SMILES Clc1ccc(c(\C=C\C(=O)N2C[C@H](C[C@H]2C(=O)Nc2ccccc2)N2CCN(CC2)S(=O)(=O)c2ccccc2)c1)-n1cnnn1
Show InChI InChI=1S/C31H31ClN8O4S/c32-24-12-13-28(40-22-33-35-36-40)23(19-24)11-14-30(41)39-21-26(20-29(39)31(42)34-25-7-3-1-4-8-25)37-15-17-38(18-16-37)45(43,44)27-9-5-2-6-10-27/h1-14,19,22,26,29H,15-18,20-21H2,(H,34,42)/b14-11+/t26-,29-/m0/s1
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n/an/a 78n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238265
PNG
(US9394250, 94)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C31H33Cl2N9O5S/c1-47-31(44)35-24-7-3-20(4-8-24)28-29(33)37-30(36-28)26-16-22(19-11-13-40(14-12-19)48(2,45)46)17-41(26)27(43)10-5-21-15-23(32)6-9-25(21)42-18-34-38-39-42/h3-10,15,18-19,22,26H,11-14,16-17H2,1-2H3,(H,35,44)(H,36,37)/b10-5+/t22-,26-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238265
PNG
(US9394250, 94)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C31H33Cl2N9O5S/c1-47-31(44)35-24-7-3-20(4-8-24)28-29(33)37-30(36-28)26-16-22(19-11-13-40(14-12-19)48(2,45)46)17-41(26)27(43)10-5-21-15-23(32)6-9-25(21)42-18-34-38-39-42/h3-10,15,18-19,22,26H,11-14,16-17H2,1-2H3,(H,35,44)(H,36,37)/b10-5+/t22-,26-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238260
PNG
(US9394250, 73)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)c1ccc(cc1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C29H35N7O5S/c1-41-29(38)33-23-9-7-19(8-10-23)24-16-32-27(34-24)25-15-22(18-11-13-35(14-12-18)42(2,39)40)17-36(25)28(37)21-5-3-20(4-6-21)26(30)31/h3-10,16,18,22,25H,11-15,17H2,1-2H3,(H3,30,31)(H,32,34)(H,33,38)/t22-,25-/m0/s1
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n/an/a 3.70E+4n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238261
PNG
(US9394250, 79)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)c1ccc(NC(N)=N)cc1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C29H35ClN8O5S/c1-43-29(40)34-22-7-3-18(4-8-22)24-25(30)36-26(35-24)23-15-20(17-11-13-37(14-12-17)44(2,41)42)16-38(23)27(39)19-5-9-21(10-6-19)33-28(31)32/h3-10,17,20,23H,11-16H2,1-2H3,(H,34,40)(H,35,36)(H4,31,32,33)/t20-,23-/m0/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238263
PNG
(US9394250, 88)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)N1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C27H38ClN9O5S/c1-42-26(38)31-20-5-3-18(4-6-20)22-23(28)33-24(32-22)21-15-19(17-7-9-36(10-8-17)43(2,40)41)16-37(21)27(39)35-13-11-34(12-14-35)25(29)30/h3-6,17,19,21H,7-16H2,1-2H3,(H3,29,30)(H,31,38)(H,32,33)/t19-,21-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238267
PNG
(US9394250, 99)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CCC(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C28H39ClN8O5S/c1-42-28(39)32-20-9-7-17(8-10-20)23-24(29)34-26(33-23)22-15-21(35-11-13-36(14-12-35)43(2,40)41)16-37(22)27(38)19-5-3-18(4-6-19)25(30)31/h7-10,18-19,21-22H,3-6,11-16H2,1-2H3,(H3,30,31)(H,32,39)(H,33,34)/t18?,19?,21-,22-/m0/s1
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n/an/a 8.40E+4n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238259
PNG
(US9394250, 71)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C28H39ClN8O5S/c1-42-28(39)32-21-5-3-18(4-6-21)23-24(29)34-25(33-23)22-15-20(17-9-13-36(14-10-17)43(2,40)41)16-37(22)26(38)19-7-11-35(12-8-19)27(30)31/h3-6,17,19-20,22H,7-16H2,1-2H3,(H3,30,31)(H,32,39)(H,33,34)/t20-,22-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238251
PNG
(US9394250, 9)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@H]1C[C@H](N(C1)C(=O)C1CCN(CC1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H35N7O6S/c1-38(36,37)30-12-10-28(11-13-30)19-14-20(21(32)27-18-4-2-17(3-5-18)23(34)35)31(15-19)22(33)16-6-8-29(9-7-16)24(25)26/h2-5,16,19-20H,6-15H2,1H3,(H3,25,26)(H,27,32)(H,34,35)/t19-,20-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238258
PNG
(US9394250, 69)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C28H40N8O5S/c1-41-28(38)32-22-5-3-19(4-6-22)23-16-31-25(33-23)24-15-21(18-9-13-35(14-10-18)42(2,39)40)17-36(24)26(37)20-7-11-34(12-8-20)27(29)30/h3-6,16,18,20-21,24H,7-15,17H2,1-2H3,(H3,29,30)(H,31,33)(H,32,38)/t21-,24-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238257
PNG
(US9394250, 57)
Show SMILES C[C@H]1CN(CCN1S(N)(=O)=O)[C@H]1C[C@H](N(C1)C(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C26H30ClN9O4S/c1-18-15-33(11-12-36(18)41(28,39)40)22-14-24(26(38)30-21-5-3-2-4-6-21)34(16-22)25(37)10-7-19-13-20(27)8-9-23(19)35-17-29-31-32-35/h2-10,13,17-18,22,24H,11-12,14-16H2,1H3,(H,30,38)(H2,28,39,40)/b10-7+/t18-,22-,24-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238251
PNG
(US9394250, 9)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@H]1C[C@H](N(C1)C(=O)C1CCN(CC1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H35N7O6S/c1-38(36,37)30-12-10-28(11-13-30)19-14-20(21(32)27-18-4-2-17(3-5-18)23(34)35)31(15-19)22(33)16-6-8-29(9-7-16)24(25)26/h2-5,16,19-20H,6-15H2,1H3,(H3,25,26)(H,27,32)(H,34,35)/t19-,20-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238252
PNG
(US9394250, 20)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@H]1C[C@H](N(C1)C(=O)c1ccc(cc1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H30N6O6S/c1-38(36,37)30-12-10-29(11-13-30)20-14-21(23(32)28-19-8-6-18(7-9-19)25(34)35)31(15-20)24(33)17-4-2-16(3-5-17)22(26)27/h2-9,20-21H,10-15H2,1H3,(H3,26,27)(H,28,32)(H,34,35)/t20-,21-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238257
PNG
(US9394250, 57)
Show SMILES C[C@H]1CN(CCN1S(N)(=O)=O)[C@H]1C[C@H](N(C1)C(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C26H30ClN9O4S/c1-18-15-33(11-12-36(18)41(28,39)40)22-14-24(26(38)30-21-5-3-2-4-6-21)34(16-22)25(37)10-7-19-13-20(27)8-9-23(19)35-17-29-31-32-35/h2-10,13,17-18,22,24H,11-12,14-16H2,1H3,(H,30,38)(H2,28,39,40)/b10-7+/t18-,22-,24-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238254
PNG
(US9394250, 39)
Show SMILES Clc1ccc(c(\C=C\C(=O)N2C[C@H](C[C@H]2C(=O)Nc2ccccc2)N2CCN(CC2)S(=O)(=O)c2ccccc2)c1)-n1cnnn1
Show InChI InChI=1S/C31H31ClN8O4S/c32-24-12-13-28(40-22-33-35-36-40)23(19-24)11-14-30(41)39-21-26(20-29(39)31(42)34-25-7-3-1-4-8-25)37-15-17-38(18-16-37)45(43,44)27-9-5-2-6-10-27/h1-14,19,22,26,29H,15-18,20-21H2,(H,34,42)/b14-11+/t26-,29-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238260
PNG
(US9394250, 73)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)c1ccc(cc1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C29H35N7O5S/c1-41-29(38)33-23-9-7-19(8-10-23)24-16-32-27(34-24)25-15-22(18-11-13-35(14-12-18)42(2,39)40)17-36(25)28(37)21-5-3-20(4-6-21)26(30)31/h3-10,16,18,22,25H,11-15,17H2,1-2H3,(H3,30,31)(H,32,34)(H,33,38)/t22-,25-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238262
PNG
(US9394250, 86)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)[C@H]1CCC(CC1)[C@H](C)N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C30H43ClN6O5S/c1-18(32)19-4-6-22(7-5-19)29(38)37-17-23(20-12-14-36(15-13-20)43(3,40)41)16-25(37)28-34-26(27(31)35-28)21-8-10-24(11-9-21)33-30(39)42-2/h8-11,18-20,22-23,25H,4-7,12-17,32H2,1-3H3,(H,33,39)(H,34,35)/t18-,19?,22-,23-,25-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238266
PNG
(US9394250, 96)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)[C@H]1CC[C@H](CN)CC1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C29H41ClN6O5S/c1-41-29(38)32-23-9-7-20(8-10-23)25-26(30)34-27(33-25)24-15-22(19-11-13-35(14-12-19)42(2,39)40)17-36(24)28(37)21-5-3-18(16-31)4-6-21/h7-10,18-19,21-22,24H,3-6,11-17,31H2,1-2H3,(H,32,38)(H,33,34)/t18-,21-,22-,24-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238259
PNG
(US9394250, 71)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C28H39ClN8O5S/c1-42-28(39)32-21-5-3-18(4-6-21)23-24(29)34-25(33-23)22-15-20(17-9-13-36(14-10-17)43(2,40)41)16-37(22)26(38)19-7-11-35(12-8-19)27(30)31/h3-6,17,19-20,22H,7-16H2,1-2H3,(H3,30,31)(H,32,39)(H,33,34)/t20-,22-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238256
PNG
(US9394250, 55)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(cc1)C(O)=O)N1CCN(CC1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C27H39N5O6S/c28-16-18-1-3-19(4-2-18)26(34)32-17-22(30-11-13-31(14-12-30)39(37,38)23-9-10-23)15-24(32)25(33)29-21-7-5-20(6-8-21)27(35)36/h5-8,18-19,22-24H,1-4,9-17,28H2,(H,29,33)(H,35,36)/t18-,19-,22-,24-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238267
PNG
(US9394250, 99)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CCC(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C28H39ClN8O5S/c1-42-28(39)32-20-9-7-17(8-10-20)23-24(29)34-26(33-23)22-15-21(35-11-13-36(14-12-35)43(2,40)41)16-37(22)27(38)19-5-3-18(4-6-19)25(30)31/h7-10,18-19,21-22H,3-6,11-16H2,1-2H3,(H3,30,31)(H,32,39)(H,33,34)/t18?,19?,21-,22-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238264
PNG
(US9394250, 93)
Show SMILES Cn1cc(Cl)c2c(F)c(ccc12)C(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(cc1)C(O)=O)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C28H30ClFN4O6S/c1-32-15-21(29)24-22(32)8-7-20(25(24)30)27(36)34-14-18(16-9-11-33(12-10-16)41(2,39)40)13-23(34)26(35)31-19-5-3-17(4-6-19)28(37)38/h3-8,15-16,18,23H,9-14H2,1-2H3,(H,31,35)(H,37,38)/t18-,23-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238268
PNG
(US9394250, 98)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C27H39N9O5S/c1-41-27(38)31-20-5-3-18(4-6-20)22-16-30-24(32-22)23-15-21(33-11-13-35(14-12-33)42(2,39)40)17-36(23)25(37)19-7-9-34(10-8-19)26(28)29/h3-6,16,19,21,23H,7-15,17H2,1-2H3,(H3,28,29)(H,30,32)(H,31,38)/t21-,23-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238255
PNG
(US9394250, 43)
Show SMILES Clc1ccc(c(\C=C\C(=O)N2C[C@H](C[C@H]2C(=O)Nc2ccc3nn[nH]c3c2)N2CCOCC2)c1)-n1cnnn1
Show InChI InChI=1S/C25H25ClN10O3/c26-17-2-5-22(36-15-27-31-33-36)16(11-17)1-6-24(37)35-14-19(34-7-9-39-10-8-34)13-23(35)25(38)28-18-3-4-20-21(12-18)30-32-29-20/h1-6,11-12,15,19,23H,7-10,13-14H2,(H,28,38)(H,29,30,32)/b6-1+/t19-,23-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238261
PNG
(US9394250, 79)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)c1ccc(NC(N)=N)cc1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C29H35ClN8O5S/c1-43-29(40)34-22-7-3-18(4-8-22)24-25(30)36-26(35-24)23-15-20(17-11-13-37(14-12-17)44(2,41)42)16-38(23)27(39)19-5-9-21(10-6-19)33-28(31)32/h3-10,17,20,23H,11-16H2,1-2H3,(H,34,40)(H,35,36)(H4,31,32,33)/t20-,23-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238268
PNG
(US9394250, 98)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C27H39N9O5S/c1-41-27(38)31-20-5-3-18(4-6-20)22-16-30-24(32-22)23-15-21(33-11-13-35(14-12-33)42(2,39)40)17-36(23)25(37)19-7-9-34(10-8-19)26(28)29/h3-6,16,19,21,23H,7-15,17H2,1-2H3,(H3,28,29)(H,30,32)(H,31,38)/t21-,23-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238264
PNG
(US9394250, 93)
Show SMILES Cn1cc(Cl)c2c(F)c(ccc12)C(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(cc1)C(O)=O)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C28H30ClFN4O6S/c1-32-15-21(29)24-22(32)8-7-20(25(24)30)27(36)34-14-18(16-9-11-33(12-10-16)41(2,39)40)13-23(34)26(35)31-19-5-3-17(4-6-19)28(37)38/h3-8,15-16,18,23H,9-14H2,1-2H3,(H,31,35)(H,37,38)/t18-,23-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238262
PNG
(US9394250, 86)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)[C@H]1CCC(CC1)[C@H](C)N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C30H43ClN6O5S/c1-18(32)19-4-6-22(7-5-19)29(38)37-17-23(20-12-14-36(15-13-20)43(3,40)41)16-25(37)28-34-26(27(31)35-28)21-8-10-24(11-9-21)33-30(39)42-2/h8-11,18-20,22-23,25H,4-7,12-17,32H2,1-3H3,(H,33,39)(H,34,35)/t18-,19?,22-,23-,25-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238256
PNG
(US9394250, 55)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(cc1)C(O)=O)N1CCN(CC1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C27H39N5O6S/c28-16-18-1-3-19(4-2-18)26(34)32-17-22(30-11-13-31(14-12-30)39(37,38)23-9-10-23)15-24(32)25(33)29-21-7-5-20(6-8-21)27(35)36/h5-8,18-19,22-24H,1-4,9-17,28H2,(H,29,33)(H,35,36)/t18-,19-,22-,24-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238254
PNG
(US9394250, 39)
Show SMILES Clc1ccc(c(\C=C\C(=O)N2C[C@H](C[C@H]2C(=O)Nc2ccccc2)N2CCN(CC2)S(=O)(=O)c2ccccc2)c1)-n1cnnn1
Show InChI InChI=1S/C31H31ClN8O4S/c32-24-12-13-28(40-22-33-35-36-40)23(19-24)11-14-30(41)39-21-26(20-29(39)31(42)34-25-7-3-1-4-8-25)37-15-17-38(18-16-37)45(43,44)27-9-5-2-6-10-27/h1-14,19,22,26,29H,15-18,20-21H2,(H,34,42)/b14-11+/t26-,29-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238266
PNG
(US9394250, 96)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)[C@H]1CC[C@H](CN)CC1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C29H41ClN6O5S/c1-41-29(38)32-23-9-7-20(8-10-23)25-26(30)34-27(33-25)24-15-22(19-11-13-35(14-12-19)42(2,39)40)17-36(24)28(37)21-5-3-18(16-31)4-6-21/h7-10,18-19,21-22,24H,3-6,11-17,31H2,1-2H3,(H,32,38)(H,33,34)/t18-,21-,22-,24-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238269
PNG
(US9394250, 111)
Show SMILES CS(=O)(=O)N1CCC(CC1)[C@H]1C[C@H](N(C1)C(=O)c1ccc(cc1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H31N5O6S/c1-38(36,37)30-12-10-16(11-13-30)20-14-22(24(32)29-21-8-6-19(7-9-21)26(34)35)31(15-20)25(33)18-4-2-17(3-5-18)23(27)28/h2-9,16,20,22H,10-15H2,1H3,(H3,27,28)(H,29,32)(H,34,35)/t20-,22-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238253
PNG
(US9394250, 37)
Show SMILES OC(=O)c1ccc(NC(=O)[C@@H]2C[C@@H](CN2C(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)N2CCOCC2)cc1
Show InChI InChI=1S/C26H26ClN7O5/c27-19-4-7-22(34-16-28-30-31-34)18(13-19)3-8-24(35)33-15-21(32-9-11-39-12-10-32)14-23(33)25(36)29-20-5-1-17(2-6-20)26(37)38/h1-8,13,16,21,23H,9-12,14-15H2,(H,29,36)(H,37,38)/b8-3+/t21-,23-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238258
PNG
(US9394250, 69)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C28H40N8O5S/c1-41-28(38)32-22-5-3-19(4-6-22)23-16-31-25(33-23)24-15-21(18-9-13-35(14-10-18)42(2,39)40)17-36(24)26(37)20-7-11-34(12-8-20)27(29)30/h3-6,16,18,20-21,24H,7-15,17H2,1-2H3,(H3,29,30)(H,31,33)(H,32,38)/t21-,24-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238255
PNG
(US9394250, 43)
Show SMILES Clc1ccc(c(\C=C\C(=O)N2C[C@H](C[C@H]2C(=O)Nc2ccc3nn[nH]c3c2)N2CCOCC2)c1)-n1cnnn1
Show InChI InChI=1S/C25H25ClN10O3/c26-17-2-5-22(36-15-27-31-33-36)16(11-17)1-6-24(37)35-14-19(34-7-9-39-10-8-34)13-23(35)25(38)28-18-3-4-20-21(12-18)30-32-29-20/h1-6,11-12,15,19,23H,7-10,13-14H2,(H,28,38)(H,29,30,32)/b6-1+/t19-,23-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


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Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238263
PNG
(US9394250, 88)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)N1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C27H38ClN9O5S/c1-42-26(38)31-20-5-3-18(4-6-20)22-23(28)33-24(32-22)21-15-19(17-7-9-36(10-8-17)43(2,40)41)16-37(21)27(39)35-13-11-34(12-14-35)25(29)30/h3-6,17,19,21H,7-16H2,1-2H3,(H3,29,30)(H,31,38)(H,32,33)/t19-,21-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X/antithrombin III


(Homo sapiens (human))
BDBM238252
PNG
(US9394250, 20)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@H]1C[C@H](N(C1)C(=O)c1ccc(cc1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H30N6O6S/c1-38(36,37)30-12-10-29(11-13-30)20-14-21(23(32)28-19-8-6-18(7-9-19)25(34)35)31(15-20)24(33)17-4-2-16(3-5-17)22(26)27/h2-9,20-21H,10-15H2,1H3,(H3,26,27)(H,28,32)(H,34,35)/t20-,21-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM238253
PNG
(US9394250, 37)
Show SMILES OC(=O)c1ccc(NC(=O)[C@@H]2C[C@@H](CN2C(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)N2CCOCC2)cc1
Show InChI InChI=1S/C26H26ClN7O5/c27-19-4-7-22(34-16-28-30-31-34)18(13-19)3-8-24(35)33-15-21(32-9-11-39-12-10-32)14-23(33)25(36)29-20-5-1-17(2-6-20)26(37)38/h1-8,13,16,21,23H,9-12,14-15H2,(H,29,36)(H,37,38)/b8-3+/t21-,23-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%