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Patent code US9394285

Compile Data Set for Download or QSAR
Found 186 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237940
PNG
(US9394285, 21)
Show SMILES CC(C)(CO)COc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H20ClNO4/c1-20(2,10-23)11-26-13-5-3-12(4-6-13)14-7-15-16(19(24)25)9-22-18(15)8-17(14)21/h3-9,22-23H,10-11H2,1-2H3,(H,24,25)
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n/an/an/an/a 93.5n/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237952
PNG
(US9394285, 33)
Show SMILES COc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C16H12ClNO3/c1-21-10-4-2-9(3-5-10)11-6-12-13(16(19)20)8-18-15(12)7-14(11)17/h2-8,18H,1H3,(H,19,20)
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n/an/an/an/a 85.3n/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237967
PNG
(US9394285, 50)
Show SMILES O[C@H]1CCCC[C@@H]1Oc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C21H20ClNO4/c22-17-10-18-15(16(11-23-18)21(25)26)9-14(17)12-5-7-13(8-6-12)27-20-4-2-1-3-19(20)24/h5-11,19-20,23-24H,1-4H2,(H,25,26)/t19-,20-/m0/s1
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n/an/an/an/a 204n/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237972
PNG
(US9394285, 55)
Show SMILES COc1cc(ccc1OC[C@@H]1CCCN1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C21H21ClN2O4/c1-27-20-7-12(4-5-19(20)28-11-13-3-2-6-23-13)14-8-15-16(21(25)26)10-24-18(15)9-17(14)22/h4-5,7-10,13,23-24H,2-3,6,11H2,1H3,(H,25,26)/t13-/m0/s1
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n/an/an/an/a 209n/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237976
PNG
(US9394285, 59)
Show SMILES COc1cc(ccc1OCCCO)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H18ClNO5/c1-25-18-7-11(3-4-17(18)26-6-2-5-22)12-8-13-14(19(23)24)10-21-16(13)9-15(12)20/h3-4,7-10,21-22H,2,5-6H2,1H3,(H,23,24)
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n/an/an/an/a 133n/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237989
PNG
(US9394285, 72)
Show SMILES OCC1(CCC1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H18ClNO3/c21-17-9-18-15(16(10-22-18)19(24)25)8-14(17)12-2-4-13(5-3-12)20(11-23)6-1-7-20/h2-5,8-10,22-23H,1,6-7,11H2,(H,24,25)
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n/an/an/an/a 4.30n/an/an/an/a



Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237992
PNG
(US9394285, 75)
Show SMILES OCC1(CC1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H16ClNO3/c20-16-8-17-14(15(9-21-17)18(23)24)7-13(16)11-1-3-12(4-2-11)19(10-22)5-6-19/h1-4,7-9,21-22H,5-6,10H2,(H,23,24)
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Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237994
PNG
(US9394285, 77)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(CC(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C21H19ClN2O4/c22-18-11-19-16(17(12-23-19)21(26)27)10-15(18)14-3-1-13(2-4-14)9-20(25)24-5-7-28-8-6-24/h1-4,10-12,23H,5-9H2,(H,26,27)
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n/an/an/an/a 207n/an/an/an/a



Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238001
PNG
(US9394285, 84)
Show SMILES CS(=O)(=O)N1CCCC1c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H19ClN2O4S/c1-28(26,27)23-8-2-3-19(23)13-6-4-12(5-7-13)14-9-15-16(20(24)25)11-22-18(15)10-17(14)21/h4-7,9-11,19,22H,2-3,8H2,1H3,(H,24,25)
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238002
PNG
(US9394285, 86)
Show SMILES OCCOc1ccc(c(F)c1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C17H13ClFNO4/c18-14-7-16-12(13(8-20-16)17(22)23)6-11(14)10-2-1-9(5-15(10)19)24-4-3-21/h1-2,5-8,20-21H,3-4H2,(H,22,23)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237929
PNG
(US9394285, 10)
Show SMILES CC(=O)NCCOc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H17ClN2O4/c1-11(23)21-6-7-26-13-4-2-12(3-5-13)14-8-15-16(19(24)25)10-22-18(15)9-17(14)20/h2-5,8-10,22H,6-7H2,1H3,(H,21,23)(H,24,25)
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n/an/an/an/a 69.9n/an/an/an/a



Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237933
PNG
(US9394285, 14 | US9394285, 14A | US9394285, 14B)
Show SMILES COC(=O)N1CCC(C1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C21H19ClN2O4/c1-28-21(27)24-7-6-14(11-24)12-2-4-13(5-3-12)15-8-16-17(20(25)26)10-23-19(16)9-18(15)22/h2-5,8-10,14,23H,6-7,11H2,1H3,(H,25,26)
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n/an/an/an/a 101n/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237936
PNG
(US9394285, 17)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1CCNC1
Show InChI InChI=1S/C19H17ClN2O2/c20-17-8-18-15(16(10-22-18)19(23)24)7-14(17)12-3-1-11(2-4-12)13-5-6-21-9-13/h1-4,7-8,10,13,21-22H,5-6,9H2,(H,23,24)
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Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237938
PNG
(US9394285, 19)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCCN2CCOCC2)cc1
Show InChI InChI=1S/C21H21ClN2O4/c22-19-12-20-17(18(13-23-20)21(25)26)11-16(19)14-1-3-15(4-2-14)28-10-7-24-5-8-27-9-6-24/h1-4,11-13,23H,5-10H2,(H,25,26)
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Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238021
PNG
(US9394285, 107)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H19ClN4O3/c1-12(26)24-6-8-25(9-7-24)14-4-2-13(3-5-14)15-10-16-18(11-17(15)21)22-23-19(16)20(27)28/h2-5,10-11H,6-9H2,1H3,(H,22,23)(H,27,28)
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n/an/an/an/a 43.5n/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238024
PNG
(US9394285, 110)
Show SMILES OC(=O)c1n[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1CCCCC1
Show InChI InChI=1S/C20H19ClN2O2/c21-17-11-18-16(19(20(24)25)23-22-18)10-15(17)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h6-12H,1-5H2,(H,22,23)(H,24,25)
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Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238027
PNG
(US9394285, 113)
Show SMILES OC(=O)c1n[nH]c2cc(Cl)c(cc12)-c1ccc2OCCc2c1
Show InChI InChI=1S/C16H11ClN2O3/c17-12-7-13-11(15(16(20)21)19-18-13)6-10(12)8-1-2-14-9(5-8)3-4-22-14/h1-2,5-7H,3-4H2,(H,18,19)(H,20,21)
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Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238041
PNG
(US9394285, 127)
Show SMILES OCC1(CCCC1)c1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H19ClN2O3/c21-16-10-17-15(18(19(25)26)23-22-17)9-14(16)12-3-5-13(6-4-12)20(11-24)7-1-2-8-20/h3-6,9-10,24H,1-2,7-8,11H2,(H,22,23)(H,25,26)
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Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238055
PNG
(US9394285, 144)
Show SMILES OC[C@H]1COc2cc(ccc2O1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C18H14ClNO5/c19-14-5-15-12(13(6-20-15)18(22)23)4-11(14)9-1-2-16-17(3-9)24-8-10(7-21)25-16/h1-6,10,20-21H,7-8H2,(H,22,23)/t10-/m0/s1
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n/an/an/an/a 236n/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238061
PNG
(US9394285, 150 | US9394285, 151)
Show SMILES OC(=O)c1c[nH]c2cc(F)c(cc12)-c1ccc(cc1)C1CCCO1
Show InChI InChI=1S/C19H16FNO3/c20-16-9-17-14(15(10-21-17)19(22)23)8-13(16)11-3-5-12(6-4-11)18-2-1-7-24-18/h3-6,8-10,18,21H,1-2,7H2,(H,22,23)
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US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238061
PNG
(US9394285, 150 | US9394285, 151)
Show SMILES OC(=O)c1c[nH]c2cc(F)c(cc12)-c1ccc(cc1)C1CCCO1
Show InChI InChI=1S/C19H16FNO3/c20-16-9-17-14(15(10-21-17)19(22)23)8-13(16)11-3-5-12(6-4-11)18-2-1-7-24-18/h3-6,8-10,18,21H,1-2,7H2,(H,22,23)
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US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238064
PNG
(US9394285, 156)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCCC2COC2)cc1
Show InChI InChI=1S/C20H18ClNO4/c21-18-8-19-16(17(9-22-19)20(23)24)7-15(18)13-1-3-14(4-2-13)26-6-5-12-10-25-11-12/h1-4,7-9,12,22H,5-6,10-11H2,(H,23,24)
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n/an/an/an/a 31.9n/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238080
PNG
(US9394285, 174)
Show SMILES COc1nc(ccc1-c1cc2c(c[nH]c2cc1Cl)C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H18ClN3O4/c1-26-18-11(2-3-17(22-18)23-4-6-27-7-5-23)12-8-13-14(19(24)25)10-21-16(13)9-15(12)20/h2-3,8-10,21H,4-7H2,1H3,(H,24,25)
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n/an/an/an/a 15.3n/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238083
PNG
(US9394285, 177)
Show SMILES COc1cc(ccc1C(C)(C)CO)-c1cc2c(c[nH]c2cc1Cl)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C21H23ClN2O5S/c1-21(2,11-25)16-6-5-12(7-19(16)29-3)13-8-14-15(20(26)24-30(4,27)28)10-23-18(14)9-17(13)22/h5-10,23,25H,11H2,1-4H3,(H,24,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238093
PNG
(US9394285, 188)
Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2cc3c(c[nH]c3cc2Cl)C(O)=O)CC1=O
Show InChI InChI=1S/C23H24ClN3O4/c1-26-8-9-27(14-22(26)28)7-2-10-31-16-5-3-15(4-6-16)17-11-18-19(23(29)30)13-25-21(18)12-20(17)24/h3-6,11-13,25H,2,7-10,14H2,1H3,(H,29,30)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237963
PNG
(US9394285, 44)
Show SMILES COc1ccc(c(F)c1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C16H11ClFNO3/c1-22-8-2-3-9(14(18)4-8)10-5-11-12(16(20)21)7-19-15(11)6-13(10)17/h2-7,19H,1H3,(H,20,21)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237975
PNG
(US9394285, 58)
Show SMILES OCCCOc1ccc(cc1F)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C18H15ClFNO4/c19-14-8-16-12(13(9-21-16)18(23)24)7-11(14)10-2-3-17(15(20)6-10)25-5-1-4-22/h2-3,6-9,21-22H,1,4-5H2,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237980
PNG
(US9394285, 63)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1CCN1
Show InChI InChI=1S/C18H15ClN2O2/c19-15-8-17-13(14(9-21-17)18(22)23)7-12(15)10-1-3-11(4-2-10)16-5-6-20-16/h1-4,7-9,16,20-21H,5-6H2,(H,22,23)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237987
PNG
(US9394285, 70)
Show SMILES NC(=O)COc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C17H13ClN2O4/c18-14-6-15-12(13(7-20-15)17(22)23)5-11(14)9-1-3-10(4-2-9)24-8-16(19)21/h1-7,20H,8H2,(H2,19,21)(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238004
PNG
(US9394285, 88)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1(CC1)C(O)=O
Show InChI InChI=1S/C19H14ClNO4/c20-15-8-16-13(14(9-21-16)17(22)23)7-12(15)10-1-3-11(4-2-10)19(5-6-19)18(24)25/h1-4,7-9,21H,5-6H2,(H,22,23)(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237932
PNG
(US9394285, 13)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1F)C1(O)CCC1
Show InChI InChI=1S/C19H15ClFNO3/c20-15-8-17-13(14(9-22-17)18(23)24)7-12(15)11-3-2-10(6-16(11)21)19(25)4-1-5-19/h2-3,6-9,22,25H,1,4-5H2,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237937
PNG
(US9394285, 18)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OC2COC2)cc1
Show InChI InChI=1S/C18H14ClNO4/c19-16-6-17-14(15(7-20-17)18(21)22)5-13(16)10-1-3-11(4-2-10)24-12-8-23-9-12/h1-7,12,20H,8-9H2,(H,21,22)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238022
PNG
(US9394285, 108)
Show SMILES CC(O)(c1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C17H12ClF3N2O3/c1-16(26,17(19,20)21)9-4-2-8(3-5-9)10-6-11-13(7-12(10)18)22-23-14(11)15(24)25/h2-7,26H,1H3,(H,22,23)(H,24,25)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238030
PNG
(US9394285, 116)
Show SMILES OC(=O)c1n[nH]c2cc(Cl)c(cc12)-c1ccc2CCCc2c1
Show InChI InChI=1S/C17H13ClN2O2/c18-14-8-15-13(16(17(21)22)20-19-15)7-12(14)11-5-4-9-2-1-3-10(9)6-11/h4-8H,1-3H2,(H,19,20)(H,21,22)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238043
PNG
(US9394285, 130)
Show SMILES OC(=O)c1n[nH]c2cc(F)c(cc12)-c1ccc(cc1)C1CCOCC1
Show InChI InChI=1S/C19H17FN2O3/c20-16-10-17-15(18(19(23)24)22-21-17)9-14(16)13-3-1-11(2-4-13)12-5-7-25-8-6-12/h1-4,9-10,12H,5-8H2,(H,21,22)(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238053
PNG
(US9394285, 142)
Show SMILES OCC1(CCC1)c1ccc(cc1F)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H17ClFNO3/c21-16-8-18-13(14(9-23-18)19(25)26)7-12(16)11-2-3-15(17(22)6-11)20(10-24)4-1-5-20/h2-3,6-9,23-24H,1,4-5,10H2,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238059
PNG
(US9394285, 148)
Show SMILES CC(C)(CO)c1ccc(cc1O)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H18ClNO4/c1-19(2,9-22)14-4-3-10(5-17(14)23)11-6-12-13(18(24)25)8-21-16(12)7-15(11)20/h3-8,21-23H,9H2,1-2H3,(H,24,25)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM60982
PNG
(US9394285, 153)
Show SMILES OC(=O)c1c[nH]c2cc(F)c(-c3ccc(cc3)[C@@H]3CCCO3)c(F)c12
Show InChI InChI=1S/C19H15F2NO3/c20-13-8-14-17(12(9-22-14)19(23)24)18(21)16(13)11-5-3-10(4-6-11)15-2-1-7-25-15/h3-6,8-9,15,22H,1-2,7H2,(H,23,24)/t15-/m0/s1
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238065
PNG
(US9394285, 157)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCCCC2COC2)cc1
Show InChI InChI=1S/C21H20ClNO4/c22-19-9-20-17(18(10-23-20)21(24)25)8-16(19)14-3-5-15(6-4-14)27-7-1-2-13-11-26-12-13/h3-6,8-10,13,23H,1-2,7,11-12H2,(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238067
PNG
(US9394285, 159)
Show SMILES COC[C@H](C)Oc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H18ClNO4/c1-11(10-24-2)25-13-5-3-12(4-6-13)14-7-15-16(19(22)23)9-21-18(15)8-17(14)20/h3-9,11,21H,10H2,1-2H3,(H,22,23)/t11-/m0/s1
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238076
PNG
(US9394285, 168)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1CCCOC1
Show InChI InChI=1S/C20H18ClNO3/c21-18-9-19-16(17(10-22-19)20(23)24)8-15(18)13-5-3-12(4-6-13)14-2-1-7-25-11-14/h3-6,8-10,14,22H,1-2,7,11H2,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238077
PNG
(US9394285, 169 | US9394285, 170)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(c(F)c12)-c1ccc(cc1)C1CCCCO1
Show InChI InChI=1S/C20H17ClFNO3/c21-14-9-15-18(13(10-23-15)20(24)25)19(22)17(14)12-6-4-11(5-7-12)16-3-1-2-8-26-16/h4-7,9-10,16,23H,1-3,8H2,(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237946
PNG
(US9394285, 27)
Show SMILES Cc1cc2[nH]cc(C(O)=O)c2cc1-c1ccc(cc1)C1(CO)CC1
Show InChI InChI=1S/C20H19NO3/c1-12-8-18-16(17(10-21-18)19(23)24)9-15(12)13-2-4-14(5-3-13)20(11-22)6-7-20/h2-5,8-10,21-22H,6-7,11H2,1H3,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237947
PNG
(US9394285, 28)
Show SMILES OCCCOc1ccc(cc1)-c1c(F)cc2[nH]cc(C(O)=O)c2c1F
Show InChI InChI=1S/C18H15F2NO4/c19-13-8-14-16(12(9-21-14)18(23)24)17(20)15(13)10-2-4-11(5-3-10)25-7-1-6-22/h2-5,8-9,21-22H,1,6-7H2,(H,23,24)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237951
PNG
(US9394285, 32)
Show SMILES COc1ccc(cc1)-c1cc2c(c[nH]c2cc1C#N)C(O)=O
Show InChI InChI=1S/C17H12N2O3/c1-22-12-4-2-10(3-5-12)13-7-14-15(17(20)21)9-19-16(14)6-11(13)8-18/h2-7,9,19H,1H3,(H,20,21)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237953
PNG
(US9394285, 34)
Show SMILES COc1ccc(cc1)-c1cc2c(c[nH]c2cc1F)C(O)=O
Show InChI InChI=1S/C16H12FNO3/c1-21-10-4-2-9(3-5-10)11-6-12-13(16(19)20)8-18-15(12)7-14(11)17/h2-8,18H,1H3,(H,19,20)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237960
PNG
(US9394285, 41)
Show SMILES Cc1cc(ccc1C1(O)CCC1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H18ClNO3/c1-11-7-12(3-4-16(11)20(25)5-2-6-20)13-8-14-15(19(23)24)10-22-18(14)9-17(13)21/h3-4,7-10,22,25H,2,5-6H2,1H3,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237961
PNG
(US9394285, 42)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(c(F)c1)C1(O)CCC1
Show InChI InChI=1S/C19H15ClFNO3/c20-15-8-17-12(13(9-22-17)18(23)24)7-11(15)10-2-3-14(16(21)6-10)19(25)4-1-5-19/h2-3,6-9,22,25H,1,4-5H2,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237965
PNG
(US9394285, 47)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OC[C@@H]2CCCN2)cc1
Show InChI InChI=1S/C20H19ClN2O3/c21-18-9-19-16(17(10-23-19)20(24)25)8-15(18)12-3-5-14(6-4-12)26-11-13-2-1-7-22-13/h3-6,8-10,13,22-23H,1-2,7,11H2,(H,24,25)/t13-/m0/s1
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237984
PNG
(US9394285, 67)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)-c1ccccc1O
Show InChI InChI=1S/C21H14ClNO3/c22-18-10-19-16(17(11-23-19)21(25)26)9-15(18)13-7-5-12(6-8-13)14-3-1-2-4-20(14)24/h1-11,23-24H,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237998
PNG
(US9394285, 81)
Show SMILES OCCOc1ccc(cc1F)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C17H13ClFNO4/c18-13-7-15-11(12(8-20-15)17(22)23)6-10(13)9-1-2-16(14(19)5-9)24-4-3-21/h1-2,5-8,20-21H,3-4H2,(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM60978
PNG
(6-Chloro-5-(4-methoxyphenyl)-1H-indazole-3-carboxy...)
Show SMILES COc1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C15H11ClN2O3/c1-21-9-4-2-8(3-5-9)10-6-11-13(7-12(10)16)17-18-14(11)15(19)20/h2-7H,1H3,(H,17,18)(H,19,20)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238013
PNG
(US9394285, 99)
Show SMILES CCOc1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C16H13ClN2O3/c1-2-22-10-5-3-9(4-6-10)11-7-12-14(8-13(11)17)18-19-15(12)16(20)21/h3-8H,2H2,1H3,(H,18,19)(H,20,21)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237926
PNG
(US9394285, 7)
Show SMILES OCc1ccc(cc1)-c1cc2c(c[nH]c2cc1F)C(O)=O
Show InChI InChI=1S/C16H12FNO3/c17-14-6-15-12(13(7-18-15)16(20)21)5-11(14)10-3-1-9(8-19)2-4-10/h1-7,18-19H,8H2,(H,20,21)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237930
PNG
(US9394285, 11)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(CC(=O)N2CCC2)cc1
Show InChI InChI=1S/C20H17ClN2O3/c21-17-10-18-15(16(11-22-18)20(25)26)9-14(17)13-4-2-12(3-5-13)8-19(24)23-6-1-7-23/h2-5,9-11,22H,1,6-8H2,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237935
PNG
(US9394285, 16)
Show SMILES CS(=O)(=O)N1CCC(C1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H19ClN2O4S/c1-28(26,27)23-7-6-14(11-23)12-2-4-13(5-3-12)15-8-16-17(20(24)25)10-22-19(16)9-18(15)21/h2-5,8-10,14,22H,6-7,11H2,1H3,(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238031
PNG
(US9394285, 117)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C21H20ClN3O3/c1-12(26)25-8-6-14(7-9-25)13-2-4-15(5-3-13)16-10-17-19(11-18(16)22)23-24-20(17)21(27)28/h2-5,10-11,14H,6-9H2,1H3,(H,23,24)(H,27,28)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238035
PNG
(US9394285, 121)
Show SMILES OC(=O)c1n[nH]c2cc(Cl)c(cc12)-c1ccc2OCCOc2c1
Show InChI InChI=1S/C16H11ClN2O4/c17-11-7-12-10(15(16(20)21)19-18-12)6-9(11)8-1-2-13-14(5-8)23-4-3-22-13/h1-2,5-7H,3-4H2,(H,18,19)(H,20,21)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238038
PNG
(US9394285, 124)
Show SMILES OC(=O)c1n[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1CCOC1
Show InChI InChI=1S/C18H15ClN2O3/c19-15-8-16-14(17(18(22)23)21-20-16)7-13(15)11-3-1-10(2-4-11)12-5-6-24-9-12/h1-4,7-8,12H,5-6,9H2,(H,20,21)(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238039
PNG
(US9394285, 125)
Show SMILES COC(C)c1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C17H15ClN2O3/c1-9(23-2)10-3-5-11(6-4-10)12-7-13-15(8-14(12)18)19-20-16(13)17(21)22/h3-9H,1-2H3,(H,19,20)(H,21,22)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238045
PNG
(US9394285, 132)
Show SMILES COc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)S(O)(=O)=O
Show InChI InChI=1S/C15H12ClNO4S/c1-21-10-4-2-9(3-5-10)11-6-12-14(7-13(11)16)17-8-15(12)22(18,19)20/h2-8,17H,1H3,(H,18,19,20)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238057
PNG
(US9394285, 146)
Show SMILES COc1cc(ccc1[C@H]1C[C@H](O)C1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H18ClNO4/c1-26-19-6-10(2-3-13(19)11-4-12(23)5-11)14-7-15-16(20(24)25)9-22-18(15)8-17(14)21/h2-3,6-9,11-12,22-23H,4-5H2,1H3,(H,24,25)/t11-,12-
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238058
PNG
(US9394285, 147)
Show SMILES CS(=O)(=O)NC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1(O)CCC1
Show InChI InChI=1S/C20H19ClN2O4S/c1-28(26,27)23-19(24)16-11-22-18-10-17(21)14(9-15(16)18)12-3-5-13(6-4-12)20(25)7-2-8-20/h3-6,9-11,22,25H,2,7-8H2,1H3,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238071
PNG
(US9394285, 163)
Show SMILES CC(C)(CO)c1ccc(cc1F)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H17ClFNO3/c1-19(2,9-23)14-4-3-10(5-16(14)21)11-6-12-13(18(24)25)8-22-17(12)7-15(11)20/h3-8,22-23H,9H2,1-2H3,(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238052
PNG
(US9394285, 141 | US9394285, 167)
Show SMILES OCC1(CCC1)c1ccc(cc1)-c1c(F)cc2[nH]cc(C(O)=O)c2c1F
Show InChI InChI=1S/C20H17F2NO3/c21-14-8-15-17(13(9-23-15)19(25)26)18(22)16(14)11-2-4-12(5-3-11)20(10-24)6-1-7-20/h2-5,8-9,23-24H,1,6-7,10H2,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238078
PNG
(US9394285, 171 | US9394285, 172)
Show SMILES OC(=O)c1c[nH]c2cc(F)c(cc12)-c1ccc(cc1)C1CCCCO1
Show InChI InChI=1S/C20H18FNO3/c21-17-10-18-15(16(11-22-18)20(23)24)9-14(17)12-4-6-13(7-5-12)19-3-1-2-8-25-19/h4-7,9-11,19,22H,1-3,8H2,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238084
PNG
(US9394285, 178 | US9394285, 179)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1CCCCO1
Show InChI InChI=1S/C20H18ClNO3/c21-17-10-18-15(16(11-22-18)20(23)24)9-14(17)12-4-6-13(7-5-12)19-3-1-2-8-25-19/h4-7,9-11,19,22H,1-3,8H2,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238085
PNG
(US9394285, 180)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCCn2cccn2)cc1
Show InChI InChI=1S/C20H16ClN3O3/c21-18-11-19-16(17(12-22-19)20(25)26)10-15(18)13-2-4-14(5-3-13)27-9-8-24-7-1-6-23-24/h1-7,10-12,22H,8-9H2,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238088
PNG
(US9394285, 183)
Show SMILES CC(CO)Oc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C18H16ClNO4/c1-10(9-21)24-12-4-2-11(3-5-12)13-6-14-15(18(22)23)8-20-17(14)7-16(13)19/h2-8,10,20-21H,9H2,1H3,(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238089
PNG
(US9394285, 184)
Show SMILES COc1nc(ccc1-c1cc2c(c[nH]c2cc1Cl)C(O)=O)N1CC[C@H](O)C1
Show InChI InChI=1S/C19H18ClN3O4/c1-27-18-11(2-3-17(22-18)23-5-4-10(24)9-23)12-6-13-14(19(25)26)8-21-16(13)7-15(12)20/h2-3,6-8,10,21,24H,4-5,9H2,1H3,(H,25,26)/t10-/m0/s1
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238090
PNG
(US9394285, 185)
Show SMILES COc1nc(ccc1-c1cc2c(c[nH]c2cc1Cl)C(O)=O)N1CC[C@@H](O)C1
Show InChI InChI=1S/C19H18ClN3O4/c1-27-18-11(2-3-17(22-18)23-5-4-10(24)9-23)12-6-13-14(19(25)26)8-21-16(13)7-15(12)20/h2-3,6-8,10,21,24H,4-5,9H2,1H3,(H,25,26)/t10-/m1/s1
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237958
PNG
(US9394285, 39)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCCCN2CCOCC2)cc1
Show InChI InChI=1S/C22H23ClN2O4/c23-20-13-21-18(19(14-24-21)22(26)27)12-17(20)15-2-4-16(5-3-15)29-9-1-6-25-7-10-28-11-8-25/h2-5,12-14,24H,1,6-11H2,(H,26,27)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237970
PNG
(US9394285, 53)
Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2cc3c(c[nH]c3cc2Cl)C(O)=O)CC1
Show InChI InChI=1S/C23H26ClN3O3/c1-26-8-10-27(11-9-26)7-2-12-30-17-5-3-16(4-6-17)18-13-19-20(23(28)29)15-25-22(19)14-21(18)24/h3-6,13-15,25H,2,7-12H2,1H3,(H,28,29)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237977
PNG
(US9394285, 60 | US9394285, 61)
Show SMILES COc1cc(ccc1C1(O)COC1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H16ClNO5/c1-25-17-4-10(2-3-14(17)19(24)8-26-9-19)11-5-12-13(18(22)23)7-21-16(12)6-15(11)20/h2-7,21,24H,8-9H2,1H3,(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237982
PNG
(US9394285, 65)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C22H21ClN2O3/c1-13(26)25-8-6-15(7-9-25)14-2-4-16(5-3-14)17-10-18-19(22(27)28)12-24-21(18)11-20(17)23/h2-5,10-12,15,24H,6-9H2,1H3,(H,27,28)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237985
PNG
(US9394285, 68)
Show SMILES OC(=O)c1c[nH]c2cc(Br)c(cc12)-c1ccc(cc1)-c1ccccc1O
Show InChI InChI=1S/C21H14BrNO3/c22-18-10-19-16(17(11-23-19)21(25)26)9-15(18)13-7-5-12(6-8-13)14-3-1-2-4-20(14)24/h1-11,23-24H,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237986
PNG
(US9394285, 69)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1C#N)C1(O)CCC1
Show InChI InChI=1S/C20H15ClN2O3/c21-17-8-18-15(16(10-23-18)19(24)25)7-14(17)13-3-2-12(6-11(13)9-22)20(26)4-1-5-20/h2-3,6-8,10,23,26H,1,4-5H2,(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237995
PNG
(US9394285, 78)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1(CCC1)C(O)=O
Show InChI InChI=1S/C20H16ClNO4/c21-16-9-17-14(15(10-22-17)18(23)24)8-13(16)11-2-4-12(5-3-11)20(19(25)26)6-1-7-20/h2-5,8-10,22H,1,6-7H2,(H,23,24)(H,25,26)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238012
PNG
(US9394285, 98)
Show SMILES COc1ccc(c(F)c1)-c1cc2c(n[nH]c2cc1C)C(O)=O
Show InChI InChI=1S/C16H13FN2O3/c1-8-5-14-12(15(16(20)21)19-18-14)7-11(8)10-4-3-9(22-2)6-13(10)17/h3-7H,1-2H3,(H,18,19)(H,20,21)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237921
PNG
(US9394285, 2)
Show SMILES OCc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C16H12ClNO3/c17-14-6-15-12(13(7-18-15)16(20)21)5-11(14)10-3-1-9(8-19)2-4-10/h1-7,18-19H,8H2,(H,20,21)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237924
PNG
(US9394285, 5)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1(O)COC1
Show InChI InChI=1S/C18H14ClNO4/c19-15-6-16-13(14(7-20-16)17(21)22)5-12(15)10-1-3-11(4-2-10)18(23)8-24-9-18/h1-7,20,23H,8-9H2,(H,21,22)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238023
PNG
(US9394285, 109)
Show SMILES OCCc1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C16H13ClN2O3/c17-13-8-14-12(15(16(21)22)19-18-14)7-11(13)10-3-1-9(2-4-10)5-6-20/h1-4,7-8,20H,5-6H2,(H,18,19)(H,21,22)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238029
PNG
(US9394285, 115)
Show SMILES CC(C)(CO)c1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C18H17ClN2O3/c1-18(2,9-22)11-5-3-10(4-6-11)12-7-13-15(8-14(12)19)20-21-16(13)17(23)24/h3-8,22H,9H2,1-2H3,(H,20,21)(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238042
PNG
(US9394285, 128)
Show SMILES OC(=O)c1n[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C18H16ClN3O3/c19-15-10-16-14(17(18(23)24)21-20-16)9-13(15)11-1-3-12(4-2-11)22-5-7-25-8-6-22/h1-4,9-10H,5-8H2,(H,20,21)(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238049
PNG
(US9394285, 136)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1CCOCC1
Show InChI InChI=1S/C20H18ClNO3/c21-18-10-19-16(17(11-22-19)20(23)24)9-15(18)14-3-1-12(2-4-14)13-5-7-25-8-6-13/h1-4,9-11,13,22H,5-8H2,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238052
PNG
(US9394285, 141 | US9394285, 167)
Show SMILES OCC1(CCC1)c1ccc(cc1)-c1c(F)cc2[nH]cc(C(O)=O)c2c1F
Show InChI InChI=1S/C20H17F2NO3/c21-14-8-15-17(13(9-23-15)19(25)26)18(22)16(14)11-2-4-12(5-3-11)20(10-24)6-1-7-20/h2-5,8-9,23-24H,1,6-7,10H2,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238054
PNG
(US9394285, 143)
Show SMILES OCC1(CCC1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1F)C(O)=O
Show InChI InChI=1S/C20H18FNO3/c21-17-9-18-15(16(10-22-18)19(24)25)8-14(17)12-2-4-13(5-3-12)20(11-23)6-1-7-20/h2-5,8-10,22-23H,1,6-7,11H2,(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM60984
PNG
(US9394285, 155)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)[C@@H]1CCCO1
Show InChI InChI=1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)19(22)23)8-13(16)11-3-5-12(6-4-11)18-2-1-7-24-18/h3-6,8-10,18,21H,1-2,7H2,(H,22,23)/t18-/m0/s1
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238084
PNG
(US9394285, 178 | US9394285, 179)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1CCCCO1
Show InChI InChI=1S/C20H18ClNO3/c21-17-10-18-15(16(11-22-18)20(23)24)9-14(17)12-4-6-13(7-5-12)19-3-1-2-8-25-19/h4-7,9-11,19,22H,1-3,8H2,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237941
PNG
(US9394285, 22)
Show SMILES OCC1(CC1)c1ccc(cc1)-c1c(F)cc2[nH]cc(C(O)=O)c2c1F
Show InChI InChI=1S/C19H15F2NO3/c20-13-7-14-16(12(8-22-14)18(24)25)17(21)15(13)10-1-3-11(4-2-10)19(9-23)5-6-19/h1-4,7-8,22-23H,5-6,9H2,(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237942
PNG
(US9394285, 23)
Show SMILES OCC1(CC1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1C#N)C(O)=O
Show InChI InChI=1S/C20H16N2O3/c21-9-13-7-18-16(17(10-22-18)19(24)25)8-15(13)12-1-3-14(4-2-12)20(11-23)5-6-20/h1-4,7-8,10,22-23H,5-6,11H2,(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237943
PNG
(US9394285, 24)
Show SMILES OCCOc1ccc(cc1)-c1c(F)cc2[nH]cc(C(O)=O)c2c1F
Show InChI InChI=1S/C17H13F2NO4/c18-12-7-13-15(11(8-20-13)17(22)23)16(19)14(12)9-1-3-10(4-2-9)24-6-5-21/h1-4,7-8,20-21H,5-6H2,(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237949
PNG
(US9394285, 30)
Show SMILES OCCCOc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C18H16ClNO4/c19-16-9-17-14(15(10-20-17)18(22)23)8-13(16)11-2-4-12(5-3-11)24-7-1-6-21/h2-5,8-10,20-21H,1,6-7H2,(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237973
PNG
(US9394285, 56)
Show SMILES COc1cc(ccc1C(C)(C)O)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H18ClNO4/c1-19(2,24)14-5-4-10(6-17(14)25-3)11-7-12-13(18(22)23)9-21-16(12)8-15(11)20/h4-9,21,24H,1-3H3,(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237974
PNG
(US9394285, 57)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc2CCOc2c1
Show InChI InChI=1S/C17H12ClNO3/c18-14-7-15-12(13(8-19-15)17(20)21)6-11(14)10-2-1-9-3-4-22-16(9)5-10/h1-2,5-8,19H,3-4H2,(H,20,21)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237993
PNG
(US9394285, 76)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1cnc(nc1)N1CCOCC1
Show InChI InChI=1S/C17H15ClN4O3/c18-14-6-15-12(13(9-19-15)16(23)24)5-11(14)10-7-20-17(21-8-10)22-1-3-25-4-2-22/h5-9,19H,1-4H2,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238003
PNG
(US9394285, 87)
Show SMILES OC[C@@H]1COc2cc(ccc2O1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C18H14ClNO5/c19-14-5-15-12(13(6-20-15)18(22)23)4-11(14)9-1-2-16-17(3-9)24-8-10(7-21)25-16/h1-6,10,20-21H,7-8H2,(H,22,23)/t10-/m1/s1
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n/an/an/an/a 69.5n/an/an/an/a



Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238007
PNG
(US9394285, 91)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1CNC1
Show InChI InChI=1S/C18H15ClN2O2/c19-16-6-17-14(15(9-21-17)18(22)23)5-13(16)11-3-1-10(2-4-11)12-7-20-8-12/h1-6,9,12,20-21H,7-8H2,(H,22,23)
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237927
PNG
(US9394285, 8)
Show SMILES CC(=O)N1CC(C1)Oc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H17ClN2O4/c1-11(24)23-9-14(10-23)27-13-4-2-12(3-5-13)15-6-16-17(20(25)26)8-22-19(16)7-18(15)21/h2-8,14,22H,9-10H2,1H3,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237931
PNG
(US9394285, 12)
Show SMILES OC(=O)c1c[nH]c2cc(C#N)c(cc12)-c1ccc(cc1)C1(O)CCC1
Show InChI InChI=1S/C20H16N2O3/c21-10-13-8-18-16(17(11-22-18)19(23)24)9-15(13)12-2-4-14(5-3-12)20(25)6-1-7-20/h2-5,8-9,11,22,25H,1,6-7H2,(H,23,24)
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238025
PNG
(US9394285, 111)
Show SMILES OCc1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C15H11ClN2O3/c16-12-6-13-11(14(15(20)21)18-17-13)5-10(12)9-3-1-8(7-19)2-4-9/h1-6,19H,7H2,(H,17,18)(H,20,21)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238028
PNG
(US9394285, 114)
Show SMILES CN1CCC(CC1)c1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H20ClN3O2/c1-24-8-6-13(7-9-24)12-2-4-14(5-3-12)15-10-16-18(11-17(15)21)22-23-19(16)20(25)26/h2-5,10-11,13H,6-9H2,1H3,(H,22,23)(H,25,26)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM60979
PNG
(US9394285, 126)
Show SMILES O[C@H]1C[C@@H](C1)c1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C18H15ClN2O3/c19-15-8-16-14(17(18(23)24)21-20-16)7-13(15)10-3-1-9(2-4-10)11-5-12(22)6-11/h1-4,7-8,11-12,22H,5-6H2,(H,20,21)(H,23,24)/t11-,12-
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238046
PNG
(US9394285, 133)
Show SMILES Oc1ccccc1-c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)S(O)(=O)=O
Show InChI InChI=1S/C20H14ClNO4S/c21-17-10-18-16(20(11-22-18)27(24,25)26)9-15(17)13-7-5-12(6-8-13)14-3-1-2-4-19(14)23/h1-11,22-23H,(H,24,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238066
PNG
(US9394285, 158)
Show SMILES COC[C@@H](C)Oc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H18ClNO4/c1-11(10-24-2)25-13-5-3-12(4-6-13)14-7-15-16(19(22)23)9-21-18(15)8-17(14)20/h3-9,11,21H,10H2,1-2H3,(H,22,23)/t11-/m1/s1
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238068
PNG
(US9394285, 160)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCc2ncccn2)cc1
Show InChI InChI=1S/C20H14ClN3O3/c21-17-9-18-15(16(10-24-18)20(25)26)8-14(17)12-2-4-13(5-3-12)27-11-19-22-6-1-7-23-19/h1-10,24H,11H2,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238072
PNG
(US9394285, 164)
Show SMILES OCC1(CCC1)c1ccc(c(F)c1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H17ClFNO3/c21-16-8-18-14(15(9-23-18)19(25)26)7-13(16)12-3-2-11(6-17(12)22)20(10-24)4-1-5-20/h2-3,6-9,23-24H,1,4-5,10H2,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238077
PNG
(US9394285, 169 | US9394285, 170)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(c(F)c12)-c1ccc(cc1)C1CCCCO1
Show InChI InChI=1S/C20H17ClFNO3/c21-14-9-15-18(13(10-23-15)20(24)25)19(22)17(14)12-6-4-11(5-7-12)16-3-1-2-8-26-16/h4-7,9-10,16,23H,1-3,8H2,(H,24,25)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238081
PNG
(US9394285, 175)
Show SMILES CO[C@H]1CCN(C1)c1ccc(c(OC)n1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H20ClN3O4/c1-27-11-5-6-24(10-11)18-4-3-12(19(23-18)28-2)13-7-14-15(20(25)26)9-22-17(14)8-16(13)21/h3-4,7-9,11,22H,5-6,10H2,1-2H3,(H,25,26)/t11-/m0/s1
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238087
PNG
(US9394285, 182)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCC2CCO2)cc1
Show InChI InChI=1S/C19H16ClNO4/c20-17-8-18-15(16(9-21-18)19(22)23)7-14(17)11-1-3-12(4-2-11)25-10-13-5-6-24-13/h1-4,7-9,13,21H,5-6,10H2,(H,22,23)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238091
PNG
(US9394285, 186)
Show SMILES COc1nc(ccc1-c1cc2c(c[nH]c2cc1Cl)C(O)=O)N(C)CCO
Show InChI InChI=1S/C18H18ClN3O4/c1-22(5-6-23)16-4-3-10(17(21-16)26-2)11-7-12-13(18(24)25)9-20-15(12)8-14(11)19/h3-4,7-9,20,23H,5-6H2,1-2H3,(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237944
PNG
(US9394285, 25)
Show SMILES COc1cc(ccc1C1(O)CCC1)-c1cc2c(c[nH]c2cc1F)C(O)=O
Show InChI InChI=1S/C20H18FNO4/c1-26-18-7-11(3-4-15(18)20(25)5-2-6-20)12-8-13-14(19(23)24)10-22-17(13)9-16(12)21/h3-4,7-10,22,25H,2,5-6H2,1H3,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM60975
PNG
(4,6-difluoro-5-[4-(1-hydroxy-2-methylpropan-2-yl)p...)
Show SMILES CC(C)(CO)c1ccc(cc1)-c1c(F)cc2[nH]cc(C(O)=O)c2c1F
Show InChI InChI=1S/C19H17F2NO3/c1-19(2,9-23)11-5-3-10(4-6-11)15-13(20)7-14-16(17(15)21)12(8-22-14)18(24)25/h3-8,22-23H,9H2,1-2H3,(H,24,25)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237948
PNG
(US9394285, 29)
Show SMILES COc1cccc(c1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C16H12ClNO3/c1-21-10-4-2-3-9(5-10)11-6-12-13(16(19)20)8-18-15(12)7-14(11)17/h2-8,18H,1H3,(H,19,20)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237950
PNG
(US9394285, 31)
Show SMILES CCOc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C17H14ClNO3/c1-2-22-11-5-3-10(4-6-11)12-7-13-14(17(20)21)9-19-16(13)8-15(12)18/h3-9,19H,2H2,1H3,(H,20,21)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237956
PNG
(US9394285, 37)
Show SMILES COc1ccc(cc1OC)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C17H14ClNO4/c1-22-15-4-3-9(5-16(15)23-2)10-6-11-12(17(20)21)8-19-14(11)7-13(10)18/h3-8,19H,1-2H3,(H,20,21)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237962
PNG
(US9394285, 43)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H14ClNO2/c22-19-11-20-17(18(12-23-20)21(24)25)10-16(19)15-8-6-14(7-9-15)13-4-2-1-3-5-13/h1-12,23H,(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237966
PNG
(US9394285, 48)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCCN2CCNCC2)cc1
Show InChI InChI=1S/C21H22ClN3O3/c22-19-12-20-17(18(13-24-20)21(26)27)11-16(19)14-1-3-15(4-2-14)28-10-9-25-7-5-23-6-8-25/h1-4,11-13,23-24H,5-10H2,(H,26,27)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237979
PNG
(US9394285, 62)
Show SMILES COc1cc(ccc1-c1cc2c(c[nH]c2cc1Cl)C(O)=O)C1(O)COC1
Show InChI InChI=1S/C19H16ClNO5/c1-25-17-4-10(19(24)8-26-9-19)2-3-11(17)12-5-13-14(18(22)23)7-21-16(13)6-15(12)20/h2-7,21,24H,8-9H2,1H3,(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237991
PNG
(US9394285, 74)
Show SMILES CN1CCC(C1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H19ClN2O2/c1-23-7-6-14(11-23)12-2-4-13(5-3-12)15-8-16-17(20(24)25)10-22-19(16)9-18(15)21/h2-5,8-10,14,22H,6-7,11H2,1H3,(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237999
PNG
(US9394285, 82)
Show SMILES CNC(=O)COc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C18H15ClN2O4/c1-20-17(22)9-25-11-4-2-10(3-5-11)12-6-13-14(18(23)24)8-21-16(13)7-15(12)19/h2-8,21H,9H2,1H3,(H,20,22)(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238000
PNG
(US9394285, 83)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1CCCN1
Show InChI InChI=1S/C19H17ClN2O2/c20-16-9-18-14(15(10-22-18)19(23)24)8-13(16)11-3-5-12(6-4-11)17-2-1-7-21-17/h3-6,8-10,17,21-22H,1-2,7H2,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238014
PNG
(US9394285, 100)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C17H15ClN2O3/c1-9(2)23-11-5-3-10(4-6-11)12-7-13-15(8-14(12)18)19-20-16(13)17(21)22/h3-9H,1-2H3,(H,19,20)(H,21,22)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238018
PNG
(US9394285, 104)
Show SMILES OC(=O)c1n[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1CCOCC1
Show InChI InChI=1S/C19H17ClN2O3/c20-16-10-17-15(18(19(23)24)22-21-17)9-14(16)13-3-1-11(2-4-13)12-5-7-25-8-6-12/h1-4,9-10,12H,5-8H2,(H,21,22)(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237920
PNG
(US9394285, 1)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1(O)CCC1
Show InChI InChI=1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)18(22)23)8-13(16)11-2-4-12(5-3-11)19(24)6-1-7-19/h2-5,8-10,21,24H,1,6-7H2,(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237925
PNG
(US9394285, 6)
Show SMILES OC(=O)c1c[nH]c2cc(F)c(-c3ccc(cc3)C3(O)CCC3)c(F)c12
Show InChI InChI=1S/C19H15F2NO3/c20-13-8-14-16(12(9-22-14)18(23)24)17(21)15(13)10-2-4-11(5-3-10)19(25)6-1-7-19/h2-5,8-9,22,25H,1,6-7H2,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237933
PNG
(US9394285, 14 | US9394285, 14A | US9394285, 14B)
Show SMILES COC(=O)N1CCC(C1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C21H19ClN2O4/c1-28-21(27)24-7-6-14(11-24)12-2-4-13(5-3-12)15-8-16-17(20(25)26)10-23-19(16)9-18(15)22/h2-5,8-10,14,23H,6-7,11H2,1H3,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238020
PNG
(US9394285, 106)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H19ClN4O2/c1-23-6-8-24(9-7-23)13-4-2-12(3-5-13)14-10-15-17(11-16(14)20)21-22-18(15)19(25)26/h2-5,10-11H,6-9H2,1H3,(H,21,22)(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238036
PNG
(US9394285, 122)
Show SMILES NC(=O)C1(CCC1)c1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H16ClN3O3/c20-14-9-15-13(16(17(24)25)23-22-15)8-12(14)10-2-4-11(5-3-10)19(18(21)26)6-1-7-19/h2-5,8-9H,1,6-7H2,(H2,21,26)(H,22,23)(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238047
PNG
(US9394285, 134)
Show SMILES OS(=O)(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1CCOCC1
Show InChI InChI=1S/C19H18ClNO4S/c20-17-10-18-16(19(11-21-18)26(22,23)24)9-15(17)14-3-1-12(2-4-14)13-5-7-25-8-6-13/h1-4,9-11,13,21H,5-8H2,(H,22,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238050
PNG
(US9394285, 138)
Show SMILES O[C@H]1C[C@@H](C1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H16ClNO3/c20-17-8-18-15(16(9-21-18)19(23)24)7-14(17)11-3-1-10(2-4-11)12-5-13(22)6-12/h1-4,7-9,12-13,21-22H,5-6H2,(H,23,24)/t12-,13-
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238051
PNG
(US9394285, 139)
Show SMILES OCCOc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C17H14ClNO4/c18-15-8-16-13(14(9-19-16)17(21)22)7-12(15)10-1-3-11(4-2-10)23-6-5-20/h1-4,7-9,19-20H,5-6H2,(H,21,22)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238060
PNG
(US9394285, 149)
Show SMILES COc1nc(ccc1N1CCC(O)C1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H18ClN3O4/c1-27-18-17(23-5-4-10(24)9-23)3-2-15(22-18)12-6-11-13(19(25)26)8-21-16(11)7-14(12)20/h2-3,6-8,10,21,24H,4-5,9H2,1H3,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238069
PNG
(US9394285, 161)
Show SMILES COc1nc(ccc1-c1cc2c(c[nH]c2cc1Cl)C(O)=O)N1CCC(O)C1
Show InChI InChI=1S/C19H18ClN3O4/c1-27-18-11(2-3-17(22-18)23-5-4-10(24)9-23)12-6-13-14(19(25)26)8-21-16(13)7-15(12)20/h2-3,6-8,10,21,24H,4-5,9H2,1H3,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238074
PNG
(US9394285, 166)
Show SMILES OC(=O)c1c[nH]c2cc(F)c(-c3ccc(cc3)C3CCOCC3)c(F)c12
Show InChI InChI=1S/C20H17F2NO3/c21-15-9-16-18(14(10-23-16)20(24)25)19(22)17(15)13-3-1-11(2-4-13)12-5-7-26-8-6-12/h1-4,9-10,12,23H,5-8H2,(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238078
PNG
(US9394285, 171 | US9394285, 172)
Show SMILES OC(=O)c1c[nH]c2cc(F)c(cc12)-c1ccc(cc1)C1CCCCO1
Show InChI InChI=1S/C20H18FNO3/c21-17-10-18-15(16(11-22-18)20(23)24)9-14(17)12-4-6-13(7-5-12)19-3-1-2-8-25-19/h4-7,9-11,19,22H,1-3,8H2,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237955
PNG
(US9394285, 36)
Show SMILES CC(C)(CO)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H18ClNO3/c1-19(2,10-22)12-5-3-11(4-6-12)13-7-14-15(18(23)24)9-21-17(14)8-16(13)20/h3-9,21-22H,10H2,1-2H3,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237957
PNG
(US9394285, 38)
Show SMILES O[C@@H]1CCC[C@H]1Oc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H18ClNO4/c21-16-9-17-14(15(10-22-17)20(24)25)8-13(16)11-4-6-12(7-5-11)26-19-3-1-2-18(19)23/h4-10,18-19,22-23H,1-3H2,(H,24,25)/t18-,19-/m1/s1
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237969
PNG
(US9394285, 52)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCCCN2CCNCC2)cc1
Show InChI InChI=1S/C22H24ClN3O3/c23-20-13-21-18(19(14-25-21)22(27)28)12-17(20)15-2-4-16(5-3-15)29-11-1-8-26-9-6-24-7-10-26/h2-5,12-14,24-25H,1,6-11H2,(H,27,28)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237977
PNG
(US9394285, 60 | US9394285, 61)
Show SMILES COc1cc(ccc1C1(O)COC1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H16ClNO5/c1-25-17-4-10(2-3-14(17)19(24)8-26-9-19)11-5-12-13(18(22)23)7-21-16(12)6-15(11)20/h2-7,21,24H,8-9H2,1H3,(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237988
PNG
(US9394285, 71)
Show SMILES OCCc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C17H14ClNO3/c18-15-8-16-13(14(9-19-16)17(21)22)7-12(15)11-3-1-10(2-4-11)5-6-20/h1-4,7-9,19-20H,5-6H2,(H,21,22)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237990
PNG
(US9394285, 73)
Show SMILES CN(C)c1ncc(cn1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C15H13ClN4O2/c1-20(2)15-18-5-8(6-19-15)9-3-10-11(14(21)22)7-17-13(10)4-12(9)16/h3-7,17H,1-2H3,(H,21,22)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238010
PNG
(US9394285, 96)
Show SMILES OCC1(COC1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H16ClNO4/c20-16-6-17-14(15(7-21-17)18(23)24)5-13(16)11-1-3-12(4-2-11)19(8-22)9-25-10-19/h1-7,21-22H,8-10H2,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237923
PNG
(US9394285, 4)
Show SMILES OC(=O)c1c[nH]c2cc(F)c(cc12)-c1ccc(cc1)C1(O)CCC1
Show InChI InChI=1S/C19H16FNO3/c20-16-9-17-14(15(10-21-17)18(22)23)8-13(16)11-2-4-12(5-3-11)19(24)6-1-7-19/h2-5,8-10,21,24H,1,6-7H2,(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237933
PNG
(US9394285, 14 | US9394285, 14A | US9394285, 14B)
Show SMILES COC(=O)N1CCC(C1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C21H19ClN2O4/c1-28-21(27)24-7-6-14(11-24)12-2-4-13(5-3-12)15-8-16-17(20(25)26)10-23-19(16)9-18(15)22/h2-5,8-10,14,23H,6-7,11H2,1H3,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237934
PNG
(US9394285, 15)
Show SMILES CC(=O)N1CCC(C1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C21H19ClN2O3/c1-12(25)24-7-6-15(11-24)13-2-4-14(5-3-13)16-8-17-18(21(26)27)10-23-20(17)9-19(16)22/h2-5,8-10,15,23H,6-7,11H2,1H3,(H,26,27)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238026
PNG
(US9394285, 112)
Show SMILES OC(=O)c1n[nH]c2cc(Cl)c(cc12)-c1cccc(O)c1
Show InChI InChI=1S/C14H9ClN2O3/c15-11-6-12-10(13(14(19)20)17-16-12)5-9(11)7-2-1-3-8(18)4-7/h1-6,18H,(H,16,17)(H,19,20)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238033
PNG
(US9394285, 119)
Show SMILES OCCOc1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C16H13ClN2O4/c17-13-8-14-12(15(16(21)22)19-18-14)7-11(13)9-1-3-10(4-2-9)23-6-5-20/h1-4,7-8,20H,5-6H2,(H,18,19)(H,21,22)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238034
PNG
(US9394285, 120 | US9394285, 126)
Show SMILES O[C@H]1C[C@H](C1)c1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C18H15ClN2O3/c19-15-8-16-14(17(18(23)24)21-20-16)7-13(15)10-3-1-9(2-4-10)11-5-12(22)6-11/h1-4,7-8,11-12,22H,5-6H2,(H,20,21)(H,23,24)/t11-,12+
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238037
PNG
(US9394285, 123)
Show SMILES NC(=O)Cc1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C16H12ClN3O3/c17-12-7-13-11(15(16(22)23)20-19-13)6-10(12)9-3-1-8(2-4-9)5-14(18)21/h1-4,6-7H,5H2,(H2,18,21)(H,19,20)(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238044
PNG
(US9394285, 131)
Show SMILES COc1cc(ccc1C1(O)CCC1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H17ClN2O4/c1-26-16-7-10(3-4-13(16)19(25)5-2-6-19)11-8-12-15(9-14(11)20)21-22-17(12)18(23)24/h3-4,7-9,25H,2,5-6H2,1H3,(H,21,22)(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238048
PNG
(US9394285, 135)
Show SMILES OC(=O)c1n[nH]c2cc(F)c(cc12)-c1ccc(cc1)-c1ccccc1O
Show InChI InChI=1S/C20H13FN2O3/c21-16-10-17-15(19(20(25)26)23-22-17)9-14(16)12-7-5-11(6-8-12)13-3-1-2-4-18(13)24/h1-10,24H,(H,22,23)(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238056
PNG
(US9394285, 145)
Show SMILES COc1cc(ccc1C1(O)CCC1)-c1c(F)cc2[nH]cc(C(O)=O)c2c1F
Show InChI InChI=1S/C20H17F2NO4/c1-27-15-7-10(3-4-12(15)20(26)5-2-6-20)16-13(21)8-14-17(18(16)22)11(9-23-14)19(24)25/h3-4,7-9,23,26H,2,5-6H2,1H3,(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238063
PNG
(US9394285, 154)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1CCCO1
Show InChI InChI=1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)19(22)23)8-13(16)11-3-5-12(6-4-11)18-2-1-7-24-18/h3-6,8-10,18,21H,1-2,7H2,(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238070
PNG
(US9394285, 162)
Show SMILES CC(C)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C18H16ClNO2/c1-10(2)11-3-5-12(6-4-11)13-7-14-15(18(21)22)9-20-17(14)8-16(13)19/h3-10,20H,1-2H3,(H,21,22)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238073
PNG
(US9394285, 165)
Show SMILES OCC1(CCC1)c1ccc(c(F)c1)-c1cc2c(c[nH]c2cc1F)C(O)=O
Show InChI InChI=1S/C20H17F2NO3/c21-16-6-11(20(10-24)4-1-5-20)2-3-12(16)13-7-14-15(19(25)26)9-23-18(14)8-17(13)22/h2-3,6-9,23-24H,1,4-5,10H2,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238079
PNG
(US9394285, 173)
Show SMILES COc1nc(ccc1-c1cc2c(c[nH]c2cc1Cl)C(O)=O)N(C)C
Show InChI InChI=1S/C17H16ClN3O3/c1-21(2)15-5-4-9(16(20-15)24-3)10-6-11-12(17(22)23)8-19-14(11)7-13(10)18/h4-8,19H,1-3H3,(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238092
PNG
(US9394285, 187)
Show SMILES COC1CCN(CCCOc2ccc(cc2)-c2cc3c(c[nH]c3cc2Cl)C(O)=O)CC1
Show InChI InChI=1S/C24H27ClN2O4/c1-30-17-7-10-27(11-8-17)9-2-12-31-18-5-3-16(4-6-18)19-13-20-21(24(28)29)15-26-23(20)14-22(19)25/h3-6,13-15,17,26H,2,7-12H2,1H3,(H,28,29)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238095
PNG
(US9394285, 190)
Show SMILES OC(=O)c1c[nH]c2cc(F)c(c(F)c12)-c1ccc(OCCC2CCOC2)cc1
Show InChI InChI=1S/C21H19F2NO4/c22-16-9-17-19(15(10-24-17)21(25)26)20(23)18(16)13-1-3-14(4-2-13)28-8-6-12-5-7-27-11-12/h1-4,9-10,12,24H,5-8,11H2,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238096
PNG
(US9394285, 191)
Show SMILES OC(=O)c1c[nH]c2cc(F)c(c(F)c12)-c1ccc(OCCC2CCCO2)cc1
Show InChI InChI=1S/C21H19F2NO4/c22-16-10-17-19(15(11-24-17)21(25)26)20(23)18(16)12-3-5-14(6-4-12)28-9-7-13-2-1-8-27-13/h3-6,10-11,13,24H,1-2,7-9H2,(H,25,26)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237939
PNG
(US9394285, 20)
Show SMILES OC(=O)c1c[nH]c2cc(F)c(c(F)c12)-c1ccc(cc1)C1(O)COC1
Show InChI InChI=1S/C18H13F2NO4/c19-12-5-13-15(11(6-21-13)17(22)23)16(20)14(12)9-1-3-10(4-2-9)18(24)7-25-8-18/h1-6,21,24H,7-8H2,(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237954
PNG
(US9394285, 35)
Show SMILES Cc1cc2[nH]cc(C(O)=O)c2cc1-c1ccc(cc1)C1(O)CCC1
Show InChI InChI=1S/C20H19NO3/c1-12-9-18-16(17(11-21-18)19(22)23)10-15(12)13-3-5-14(6-4-13)20(24)7-2-8-20/h3-6,9-11,21,24H,2,7-8H2,1H3,(H,22,23)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237959
PNG
(US9394285, 40)
Show SMILES Cc1cc(ccc1-c1cc2c(c[nH]c2cc1Cl)C(O)=O)C1(O)CCC1
Show InChI InChI=1S/C20H18ClNO3/c1-11-7-12(20(25)5-2-6-20)3-4-13(11)14-8-15-16(19(23)24)10-22-18(15)9-17(14)21/h3-4,7-10,22,25H,2,5-6H2,1H3,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237964
PNG
(US9394285, 45)
Show SMILES CS(=O)(=O)N1CCC1c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H17ClN2O4S/c1-27(25,26)22-7-6-18(22)12-4-2-11(3-5-12)13-8-14-15(19(23)24)10-21-17(14)9-16(13)20/h2-5,8-10,18,21H,6-7H2,1H3,(H,23,24)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237968
PNG
(US9394285, 51)
Show SMILES Cc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C16H12ClNO2/c1-9-2-4-10(5-3-9)11-6-12-13(16(19)20)8-18-15(12)7-14(11)17/h2-8,18H,1H3,(H,19,20)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237971
PNG
(US9394285, 54)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCCCN2CCOCC2=O)cc1
Show InChI InChI=1S/C22H21ClN2O5/c23-19-11-20-17(18(12-24-20)22(27)28)10-16(19)14-2-4-15(5-3-14)30-8-1-6-25-7-9-29-13-21(25)26/h2-5,10-12,24H,1,6-9,13H2,(H,27,28)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237981
PNG
(US9394285, 64)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)N1CCCC1=O
Show InChI InChI=1S/C19H15ClN2O3/c20-16-9-17-14(15(10-21-17)19(24)25)8-13(16)11-3-5-12(6-4-11)22-7-1-2-18(22)23/h3-6,8-10,21H,1-2,7H2,(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237983
PNG
(US9394285, 66)
Show SMILES COc1cc(ccc1C(C)(C)CO)-c1cc2C(C=Nc2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H20ClNO4/c1-20(2,10-23)15-5-4-11(6-18(15)26-3)12-7-13-14(19(24)25)9-22-17(13)8-16(12)21/h4-9,14,23H,10H2,1-3H3,(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237996
PNG
(US9394285, 79)
Show SMILES OC(=O)C1CNc2cc(Cl)c(cc12)-c1ccc(cc1)C1CNC(=O)CO1
Show InChI InChI=1S/C19H17ClN2O4/c20-15-6-16-13(14(7-21-16)19(24)25)5-12(15)10-1-3-11(4-2-10)17-8-22-18(23)9-26-17/h1-6,14,17,21H,7-9H2,(H,22,23)(H,24,25)
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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237997
PNG
(US9394285, 80)
Show SMILES OCCCc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C18H16ClNO3/c19-16-9-17-14(15(10-20-17)18(22)23)8-13(16)12-5-3-11(4-6-12)2-1-7-21/h3-6,8-10,20-21H,1-2,7H2,(H,22,23)
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238005
PNG
(US9394285, 89)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCC2COC2)cc1
Show InChI InChI=1S/C19H16ClNO4/c20-17-6-18-15(16(7-21-18)19(22)23)5-14(17)12-1-3-13(4-2-12)25-10-11-8-24-9-11/h1-7,11,21H,8-10H2,(H,22,23)
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238006
PNG
(US9394285, 90)
Show SMILES OC(=O)CCOc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C18H14ClNO5/c19-15-8-16-13(14(9-20-16)18(23)24)7-12(15)10-1-3-11(4-2-10)25-6-5-17(21)22/h1-4,7-9,20H,5-6H2,(H,21,22)(H,23,24)
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238008
PNG
(US9394285, 94)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCc2cccnc2)cc1
Show InChI InChI=1S/C21H15ClN2O3/c22-19-9-20-17(18(11-24-20)21(25)26)8-16(19)14-3-5-15(6-4-14)27-12-13-2-1-7-23-10-13/h1-11,24H,12H2,(H,25,26)
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Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238009
PNG
(US9394285, 95)
Show SMILES OCCOc1ccc(cc1)-c1cc2c(c[nH]c2cc1C#N)C(O)=O
Show InChI InChI=1S/C18H14N2O4/c19-9-12-7-17-15(16(10-20-17)18(22)23)8-14(12)11-1-3-13(4-2-11)24-6-5-21/h1-4,7-8,10,20-21H,5-6H2,(H,22,23)
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238015
PNG
(US9394285, 101)
Show SMILES OC(=O)c1n[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)-c1ccccc1O
Show InChI InChI=1S/C20H13ClN2O3/c21-16-10-17-15(19(20(25)26)23-22-17)9-14(16)12-7-5-11(6-8-12)13-3-1-2-4-18(13)24/h1-10,24H,(H,22,23)(H,25,26)
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238016
PNG
(US9394285, 102)
Show SMILES CC(C)(O)c1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C17H15ClN2O3/c1-17(2,23)10-5-3-9(4-6-10)11-7-12-14(8-13(11)18)19-20-15(12)16(21)22/h3-8,23H,1-2H3,(H,19,20)(H,21,22)
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238017
PNG
(US9394285, 103)
Show SMILES OC(=O)c1n[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1(O)CCC1
Show InChI InChI=1S/C18H15ClN2O3/c19-14-9-15-13(16(17(22)23)21-20-15)8-12(14)10-2-4-11(5-3-10)18(24)6-1-7-18/h2-5,8-9,24H,1,6-7H2,(H,20,21)(H,22,23)
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Pfizer Inc.

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The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237922
PNG
(US9394285, 3)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccccc1
Show InChI InChI=1S/C15H10ClNO2/c16-13-7-14-11(12(8-17-14)15(18)19)6-10(13)9-4-2-1-3-5-9/h1-8,17H,(H,18,19)
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM237928
PNG
(US9394285, 9)
Show SMILES CC(=O)N1CC(COc2ccc(cc2)-c2cc3c(c[nH]c3cc2Cl)C(O)=O)C1
Show InChI InChI=1S/C21H19ClN2O4/c1-12(25)24-9-13(10-24)11-28-15-4-2-14(3-5-15)16-6-17-18(21(26)27)8-23-20(17)7-19(16)22/h2-8,13,23H,9-11H2,1H3,(H,26,27)
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238019
PNG
(US9394285, 105)
Show SMILES CC(=O)c1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C16H11ClN2O3/c1-8(20)9-2-4-10(5-3-9)11-6-12-14(7-13(11)17)18-19-15(12)16(21)22/h2-7H,1H3,(H,18,19)(H,21,22)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238032
PNG
(US9394285, 118)
Show SMILES COc1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H16ClN3O4S/c1-29-14-9-7-13(8-10-14)16-11-17-19(12-18(16)22)23-24-20(17)21(26)25-30(27,28)15-5-3-2-4-6-15/h2-12H,1H3,(H,23,24)(H,25,26)
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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


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More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238062
PNG
(US9394285, 152 | US9394285, 155)
Show SMILES OC(=O)c1c[nH]c2cc(F)c(-c3ccc(cc3)[C@H]3CCCO3)c(F)c12
Show InChI InChI=1S/C19H15F2NO3/c20-13-8-14-17(12(9-22-14)19(23)24)18(21)16(13)11-5-3-10(4-6-11)15-2-1-7-25-15/h3-6,8-9,15,22H,1-2,7H2,(H,23,24)/t15-/m1/s1
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238071
PNG
(US9394285, 163)
Show SMILES CC(C)(CO)c1ccc(cc1F)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C19H17ClFNO3/c1-19(2,9-23)14-4-3-10(5-16(14)21)11-6-12-13(18(24)25)8-22-17(12)7-15(11)20/h3-8,22-23H,9H2,1-2H3,(H,24,25)
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238082
PNG
(US9394285, 176)
Show SMILES CO[C@@H]1CCN(C1)c1ccc(c(OC)n1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C20H20ClN3O4/c1-27-11-5-6-24(10-11)18-4-3-12(19(23-18)28-2)13-7-14-15(20(25)26)9-22-17(14)8-16(13)21/h3-4,7-9,11,22H,5-6,10H2,1-2H3,(H,25,26)/t11-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238086
PNG
(US9394285, 181)
Show SMILES COCCOc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O
Show InChI InChI=1S/C18H16ClNO4/c1-23-6-7-24-12-4-2-11(3-5-12)13-8-14-15(18(21)22)10-20-17(14)9-16(13)19/h2-5,8-10,20H,6-7H2,1H3,(H,21,22)
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Pfizer Inc.

US Patent


Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM238094
PNG
(US9394285, 189)
Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCCCN2CC[C@@H](F)C2)cc1
Show InChI InChI=1S/C22H22ClFN2O3/c23-20-11-21-18(19(12-25-21)22(27)28)10-17(20)14-2-4-16(5-3-14)29-9-1-7-26-8-6-15(24)13-26/h2-5,10-12,15,25H,1,6-9,13H2,(H,27,28)/t15-/m1/s1
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Pfizer Inc.

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Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%